Itih4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Itih4
Entrez Gene ID	54404
Full Name	inter-alpha-trypsin inhibitor heavy chain family, member 4
General protein information	Preferred Names inter-alpha-trypsin inhibitor heavy chain family, member 4 Names inter-alpha-trypsin inhibitor heavy chain H4 inter alpha-trypsin inhibitor, heavy chain 4 inter-alpha-inhibitor H4 heavy chain
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 16 Map Location: 16p16
Summary	member of inter-alpha-inhibitor family of plasma proteins [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_019369.2	NP_062242.2	inter-alpha-trypsin inhibitor heavy chain H4 precursor

Pathways from BioSystems

Homologies

Macaca mulatta (Rhesus monkey)	ITIH4	XP_002802831.1
Canis lupus familiaris (dog)	ITIH4	XP_848765.3
Rattus norvegicus (Norway rat)	Itih4	NP_062242.2
Pan troglodytes (chimpanzee)	ITIH4	XP_001172688.1
Bos taurus (cattle)	ITIH4	NP_001015590.2
Homo sapiens (human)	ITIH4	NP_001159921.1
Mus musculus (house mouse)	Itih4	NP_061216.2
Danio rerio (zebrafish)	zgc:112265	NP_001020335.1
Xenopus tropicalis (tropical clawed frog)	LOC100487172	XP_002941978.2

Gene Ontology
Bibliography

Related articles in PubMed

Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.
Bastos-Amador P, Royo F, Gonzalez E, Conde-Vancells J, Palomo-Diez L, Borras FE, Falcon-Perez JM
Journal of proteomics75(12)3574-84(2012 Jun)

Inter-alpha-trypsin inhibitor heavy chain 4 is a novel marker of acute ischemic stroke.
Kashyap RS, Nayak AR, Deshpande PS, Kabra D, Purohit HJ, Taori GM, Daginawala HF
Clinica chimica acta; international journal of clinical chemistry402(1-2)160-3(2009 Apr)

Large-scale proteomics and phosphoproteomics of urinary exosomes.
Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal of the American Society of Nephrology : JASN20(2)363-79(2009 Feb)

Hypercholesterolemia associated with splice-junction variation of inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) gene.
Fujita Y, Ezura Y, Emi M, Sato K, Takada D, Iino Y, Katayama Y, Takahashi K, Kamimura K, Bujo H, Saito Y
Journal of human genetics49(1)24-8(2004)

Itih-4, a serine protease inhibitor regulated in interleukin-6-dependent liver formation: role in liver development and regeneration.
Bhanumathy CD, Tang Y, Monga SP, Katuri V, Cox JA, Mishra B, Mishra L
Developmental dynamics : an official publication of the American Association of Anatomists223(1)59-69(2002 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Itih4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Itih4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa04578	NM_019369.2 Latest version!	Rattus norvegicus inter-alpha-trypsin inhibitor heavy chain 4 (Itih4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Itih4 ( NM_019369.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_062242.2 Rattus norvegicus inter-alpha-trypsin inhibitor heavy chain 4 (Itih4), mRNA.

Price & Availability↑

CloneID	ORa04578
Clone ID Related Accession (Same CDS sequence)	NM_019369.2
Accession Version	NM_019369.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2802bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1555516800000
Organism	Rattus norvegicus(Norway rat)
Product	inter-alpha-trypsin inhibitor heavy chain H4 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC089806.1. On Mar 8, 2007 this sequence version replaced NM_019369.1. ##Evidence-Data-START## Transcript exon combination :: BC089806.1, Y11283.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689598, SAMEA2689599 [ECO:0000348] ##Evidence-Data-END##

ATGAAGAGCC CTGCCCCTGC CCACATGTGG AACATTGTAC TGGTCTTGCT CTCGCTGTTG 
GCTGTGCTTC CGATCACTAC TACTGAGAAG AATGGCATCG ATATCTACAG TCTCACAGTG 
GACTCCCGGG TCTCTTCCCG ATTTGCTCAT ACTGTTGTTA CCAGCCGGGT GGTCAACAGA 
GCCGATACTG TTCAAGAAGC GACCTTCCAA GTAGAGCTAC CCAGGAAAGC CTTCATCACC 
AACTTCTCCA TGATCATTGA TGGTGTGACC TACCCAGGGG TTGTCAAAGA GAAGGCTGAA 
GCCCAGAAGC AATACACTGC TGCTGTGGGC CGGGGAGAGA GCGCTGGCCT TGTCAAGACC 
ACTGGGAGAA AGACAGAGCA GTTTGAAGTG TCAGTCAACG TGGCCCCTGG TTCCAAGACT 
ACCTTCGAAC TCATATACCA AGAGCTGCTC CAAAGACGGC TGGGAATGTA TGAGCTACTC 
CTCAAAGTGA GGCCTGAGCA GCTGGTCAAG CACCTTCAGA TGGACATCTA CATCTTTGAG 
CCTCAGGGTA TCAGCACCCT GGAGACAGAG AGTACTTTCA TGACCCAGGA GTTGGCAAAT 
GCCCTTACCA CTTCACAGAA CAAGACCAAG GCACATATCC AGTTCAAGCC GACACTCTCC 
CAGCAACGGA AGTCTCAGAA TGAGCAGGAC ACGGTGCTAG ATGGGGATTT CACCGTTCGC 
TATGATGTGG ACCGGTCTTC CACTGGCGGT ACCATTCAGA TTGAGAACGG CTACTTTGTG 
CACCACTTTG CCCCAGAGGA CCTTCCTACA ATGGCCAAGA ATGTGCTCTT TGTCATTGAT 
AAAAGCGGAT CTATGGCAGG CAAGAAAATC CAACAGACCC GAGAAGCCCT AATCAAGATC 
TTGAAAGACC TCAGCACCCA AGACCAGTTC AATATCATTG TGTTCAGTGG GGAAGCAAAC 
CAGTGGGAGC AGTTGCTGGT GCAAGCAACA GAAGAGAACT TGAACAGGGC GGTTGACTAT 
GCTTCCAAGA TCCCGGCTCA GGGAGGGACC AACATCAATA AAGCAGTGCT ATCGGCTGTG 
GAACTGCTGG ATAAAAGCAA CCAGGCTGAG CTACTGCCCT CCAAGAGCGT TTCCCTCATC 
ATCCTGCTCA CGGATGGCGA GCCCACTGTG GGGGAGACCA ATCCCAAGAT TATCCAGAAG 
AACACACAGG AAGCCATCAA TGGGCGGTAT AGCCTCTTCT GCCTGGGGTT TGGCTTTGAT 
GTGAACTATC CTTTCCTGGA GAAGCTGGCC CTGGACAACG GAGGCCTGGC CCGGCGCATC 
TACGAGGACT CAGACTCTGC TCTGCAGCTT CAGGACTTCT ACCAGGAAGT GGCCAATCCG 
CTGCTGTCAT CAGTGACCTT TGAATATCCC AGCAATGCTG TGGAGGACGT CACGCGGTAC 
AACTTCCAAC ACCACTTTAA GGGCTCAGAG ATGGTGGTGG CTGGGAAGCT CCGGGACCAG 
GGCCCTGATG TCCTCTTAGC CAAAGTCAGT GGGCAGATGC ACCTGCAGAA CATCACTTTC 
CAAACGGAGG CCAGCATAGC CCAACAAGAG AAAGAGTTCC AGGGTCCTAA GTACATCTTT 
CATAACTTTA TGGAGAGACT CTGGGCGTTG CTGACCATAC AGCAACAGCT GGAGCAGAGG 
ATTTCAGCCT CAGGAGCTGA GTTAGAGGCC CTCGAGGCCC AAGTTCTGAA CTTGTCACTC 
AAGTACAATT TTGTCACTCC TCTCACGCAC ATGGTGGTCA CCAAACCTGA AGATCAAGAA 
CAATTCCAAG TTGCTGAGAA GCCTACGGAA GTCGATGGTG GAGTGTGGAG TATCCTCTCA 
GCAGTTCAAC GGCATTTCAA GACTCCTACC ACAGGATCTA AACTGCTGAC ATCCAGGCTG 
AGAGGAAATA GGTTCCAGAC ATTGTCCAGA CTCGGGGATG GTCTCGTTGG ATCTAGACAA 
TACATGCCTC CTCCTGGACT TCCTGGACCT CCTGGACTTC CTGGACCTCC TGGGCCTCCC 
GGACATCCTC ATTTTGCTTC TAGCATTGAC TACGGCAGGC AGCCTTCCTT GGGAAGGGTG 
CTAGACCTGC CATCCTTATC CTCACAAGAT CCAGCCGGCC CAAGTCTAGC CATGTTACCG 
AAAGTGGTGG AACAAGAAGG CACCACACCA GAGGAATCCC CAAACCCAGA CCACCCCCGG 
GCTCCTACCA TCATCCTGCC GCTTCCGGGA TCTGGTGTGG ACCAGCTCTG TGTGGATATC 
TTACATTCTG AGAAGCCCAT GAAGCTGTTT GTAGACATCA ATCAGGGGCT GGAGGTGGTT 
GGCAAGTATG AGAAGAATAT CGGGTTCTCA TGGATCGAAG TGACCATCCT GAAGCCTCAC 
CTGCAGGTCC ATGCAACGCC TGAACGACTG GTGGTGACAA GGGGCCGAAA AAACTCTGAA 
TACAAGTGGA AGAAGACACT GTTCTCTGTG TTACCTGGCT TAAAGATGAC CATGGATAAG 
ACGGGACTGC TACAGCTCAG TGGCCCAGAC AAAGTCACCA TCAGCCTCTT GTCTCTGGAT 
GACCCTCAGA GAGGACTCAT GCTGCTTTTG AATGACACTC ATCACTTCTC CAACGACATT 
ACAGGGGAGC TTGGTCAGTT TTACCAGGAT ATCATCTGGG ATGATACAAA ACAGACAGTC 
AGAGTTCTAG GAATCGACTA CCCGGCTACC AGAGAGCTCA AGTTGAGTTA TCAAGACGGG 
TTCCCGGGAA CAGAGATTTC CTGCTGGACG GTGAAGATAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062242.2
CDS	16..2817
Translation	MKSPAPAHMWNIVLVLLSLLAVLPITTTEKNGIDIYSLTVDSRVSSRFAHTVVTSRVVNRADTVQEATFQVELPRKAFITNFSMIIDGVTYPGVVKEKAEAQKQYTAAVGRGESAGLVKTTGRKTEQFEVSVNVAPGSKTTFELIYQELLQRRLGMYELLLKVRPEQLVKHLQMDIYIFEPQGISTLETESTFMTQELANALTTSQNKTKAHIQFKPTLSQQRKSQNEQDTVLDGDFTVRYDVDRSSTGGTIQIENGYFVHHFAPEDLPTMAKNVLFVIDKSGSMAGKKIQQTREALIKILKDLSTQDQFNIIVFSGEANQWEQLLVQATEENLNRAVDYASKIPAQGGTNINKAVLSAVELLDKSNQAELLPSKSVSLIILLTDGEPTVGETNPKIIQKNTQEAINGRYSLFCLGFGFDVNYPFLEKLALDNGGLARRIYEDSDSALQLQDFYQEVANPLLSSVTFEYPSNAVEDVTRYNFQHHFKGSEMVVAGKLRDQGPDVLLAKVSGQMHLQNITFQTEASIAQQEKEFQGPKYIFHNFMERLWALLTIQQQLEQRISASGAELEALEAQVLNLSLKYNFVTPLTHMVVTKPEDQEQFQVAEKPTEVDGGVWSILSAVQRHFKTPTTGSKLLTSRLRGNRFQTLSRLGDGLVGSRQYMPPPGLPGPPGLPGPPGPPGHPHFASSIDYGRQPSLGRVLDLPSLSSQDPAGPSLAMLPKVVEQEGTTPEESPNPDHPRAPTIILPLPGSGVDQLCVDILHSEKPMKLFVDINQGLEVVGKYEKNIGFSWIEVTILKPHLQVHATPERLVVTRGRKNSEYKWKKTLFSVLPGLKMTMDKTGLLQLSGPDKVTISLLSLDDPQRGLMLLLNDTHHFSNDITGELGQFYQDIIWDDTKQTVRVLGIDYPATRELKLSYQDGFPGTEISCWTVKI

Target ORF information:

RefSeq Version	NM_019369.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus inter-alpha-trypsin inhibitor heavy chain 4 (Itih4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019369.2

ORF Insert Sequence:

ATGAAGAGCC CTGCCCCTGC CCACATGTGG AACATTGTAC TGGTCTTGCT CTCGCTGTTG 
GCTGTGCTTC CGATCACTAC TACTGAGAAG AATGGCATCG ATATCTACAG TCTCACAGTG 
GACTCCCGGG TCTCTTCCCG ATTTGCTCAT ACTGTTGTTA CCAGCCGGGT GGTCAACAGA 
GCCGATACTG TTCAAGAAGC GACCTTCCAA GTAGAGCTAC CCAGGAAAGC CTTCATCACC 
AACTTCTCCA TGATCATTGA TGGTGTGACC TACCCAGGGG TTGTCAAAGA GAAGGCTGAA 
GCCCAGAAGC AATACACTGC TGCTGTGGGC CGGGGAGAGA GCGCTGGCCT TGTCAAGACC 
ACTGGGAGAA AGACAGAGCA GTTTGAAGTG TCAGTCAACG TGGCCCCTGG TTCCAAGACT 
ACCTTCGAAC TCATATACCA AGAGCTGCTC CAAAGACGGC TGGGAATGTA TGAGCTACTC 
CTCAAAGTGA GGCCTGAGCA GCTGGTCAAG CACCTTCAGA TGGACATCTA CATCTTTGAG 
CCTCAGGGTA TCAGCACCCT GGAGACAGAG AGTACTTTCA TGACCCAGGA GTTGGCAAAT 
GCCCTTACCA CTTCACAGAA CAAGACCAAG GCACATATCC AGTTCAAGCC GACACTCTCC 
CAGCAACGGA AGTCTCAGAA TGAGCAGGAC ACGGTGCTAG ATGGGGATTT CACCGTTCGC 
TATGATGTGG ACCGGTCTTC CACTGGCGGT ACCATTCAGA TTGAGAACGG CTACTTTGTG 
CACCACTTTG CCCCAGAGGA CCTTCCTACA ATGGCCAAGA ATGTGCTCTT TGTCATTGAT 
AAAAGCGGAT CTATGGCAGG CAAGAAAATC CAACAGACCC GAGAAGCCCT AATCAAGATC 
TTGAAAGACC TCAGCACCCA AGACCAGTTC AATATCATTG TGTTCAGTGG GGAAGCAAAC 
CAGTGGGAGC AGTTGCTGGT GCAAGCAACA GAAGAGAACT TGAACAGGGC GGTTGACTAT 
GCTTCCAAGA TCCCGGCTCA GGGAGGGACC AACATCAATA AAGCAGTGCT ATCGGCTGTG 
GAACTGCTGG ATAAAAGCAA CCAGGCTGAG CTACTGCCCT CCAAGAGCGT TTCCCTCATC 
ATCCTGCTCA CGGATGGCGA GCCCACTGTG GGGGAGACCA ATCCCAAGAT TATCCAGAAG 
AACACACAGG AAGCCATCAA TGGGCGGTAT AGCCTCTTCT GCCTGGGGTT TGGCTTTGAT 
GTGAACTATC CTTTCCTGGA GAAGCTGGCC CTGGACAACG GAGGCCTGGC CCGGCGCATC 
TACGAGGACT CAGACTCTGC TCTGCAGCTT CAGGACTTCT ACCAGGAAGT GGCCAATCCG 
CTGCTGTCAT CAGTGACCTT TGAATATCCC AGCAATGCTG TGGAGGACGT CACGCGGTAC 
AACTTCCAAC ACCACTTTAA GGGCTCAGAG ATGGTGGTGG CTGGGAAGCT CCGGGACCAG 
GGCCCTGATG TCCTCTTAGC CAAAGTCAGT GGGCAGATGC ACCTGCAGAA CATCACTTTC 
CAAACGGAGG CCAGCATAGC CCAACAAGAG AAAGAGTTCC AGGGTCCTAA GTACATCTTT 
CATAACTTTA TGGAGAGACT CTGGGCGTTG CTGACCATAC AGCAACAGCT GGAGCAGAGG 
ATTTCAGCCT CAGGAGCTGA GTTAGAGGCC CTCGAGGCCC AAGTTCTGAA CTTGTCACTC 
AAGTACAATT TTGTCACTCC TCTCACGCAC ATGGTGGTCA CCAAACCTGA AGATCAAGAA 
CAATTCCAAG TTGCTGAGAA GCCTACGGAA GTCGATGGTG GAGTGTGGAG TATCCTCTCA 
GCAGTTCAAC GGCATTTCAA GACTCCTACC ACAGGATCTA AACTGCTGAC ATCCAGGCTG 
AGAGGAAATA GGTTCCAGAC ATTGTCCAGA CTCGGGGATG GTCTCGTTGG ATCTAGACAA 
TACATGCCTC CTCCTGGACT TCCTGGACCT CCTGGACTTC CTGGACCTCC TGGGCCTCCC 
GGACATCCTC ATTTTGCTTC TAGCATTGAC TACGGCAGGC AGCCTTCCTT GGGAAGGGTG 
CTAGACCTGC CATCCTTATC CTCACAAGAT CCAGCCGGCC CAAGTCTAGC CATGTTACCG 
AAAGTGGTGG AACAAGAAGG CACCACACCA GAGGAATCCC CAAACCCAGA CCACCCCCGG 
GCTCCTACCA TCATCCTGCC GCTTCCGGGA TCTGGTGTGG ACCAGCTCTG TGTGGATATC 
TTACATTCTG AGAAGCCCAT GAAGCTGTTT GTAGACATCA ATCAGGGGCT GGAGGTGGTT 
GGCAAGTATG AGAAGAATAT CGGGTTCTCA TGGATCGAAG TGACCATCCT GAAGCCTCAC 
CTGCAGGTCC ATGCAACGCC TGAACGACTG GTGGTGACAA GGGGCCGAAA AAACTCTGAA 
TACAAGTGGA AGAAGACACT GTTCTCTGTG TTACCTGGCT TAAAGATGAC CATGGATAAG 
ACGGGACTGC TACAGCTCAG TGGCCCAGAC AAAGTCACCA TCAGCCTCTT GTCTCTGGAT 
GACCCTCAGA GAGGACTCAT GCTGCTTTTG AATGACACTC ATCACTTCTC CAACGACATT 
ACAGGGGAGC TTGGTCAGTT TTACCAGGAT ATCATCTGGG ATGATACAAA ACAGACAGTC 
AGAGTTCTAG GAATCGACTA CCCGGCTACC AGAGAGCTCA AGTTGAGTTA TCAAGACGGG 
TTCCCGGGAA CAGAGATTTC CTGCTGGACG GTGAAGATAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.
Journal of proteomics75(12)3574-84(2012 Jun)
Bastos-Amador P,Royo F,Gonzalez E,Conde-Vancells J,Palomo-Diez L,Borras FE,Falcon-Perez JM

Inter-alpha-trypsin inhibitor heavy chain 4 is a novel marker of acute ischemic stroke.
Clinica chimica acta; international journal of clinical chemistry402(1-2)160-3(2009 Apr)
Kashyap RS,Nayak AR,Deshpande PS,Kabra D,Purohit HJ,Taori GM,Daginawala HF

Large-scale proteomics and phosphoproteomics of urinary exosomes.
Journal of the American Society of Nephrology : JASN20(2)363-79(2009 Feb)
Gonzales PA,Pisitkun T,Hoffert JD,Tchapyjnikov D,Star RA,Kleta R,Wang NS,Knepper MA

Hypercholesterolemia associated with splice-junction variation of inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) gene.
Journal of human genetics49(1)24-8(2004)
Fujita Y,Ezura Y,Emi M,Sato K,Takada D,Iino Y,Katayama Y,Takahashi K,Kamimura K,Bujo H,Saito Y

Itih-4, a serine protease inhibitor regulated in interleukin-6-dependent liver formation: role in liver development and regeneration.
Developmental dynamics : an official publication of the American Association of Anatomists223(1)59-69(2002 Jan)
Bhanumathy CD,Tang Y,Monga SP,Katuri V,Cox JA,Mishra B,Mishra L

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Itih4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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