| Gene Symbol | Rspo1 |
| Entrez Gene ID | 313589 |
| Full Name | R-spondin 1 |
| Synonyms | RGD1565558 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Rattus norvegicus(Norway rat) |
| Genome |
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Rspo1 cDNA ORF clone, Rattus norvegicus(Norway rat)
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Gene
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Clones
gRNAs
The following Rspo1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rspo1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID ORa12555 Clone ID Related Accession (Same CDS sequence) XM_008764019.2 , NM_001107980.1 Accession Version NM_001107980.1 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 789bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1555516800000 Organism Rattus norvegicus(Norway rat) Product R-spondin-1 precursor Comment Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473968.1. On or before Oct 4, 2007 this sequence version replaced XM_233520.4, XM_001056937.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: BC168963.1 [ECO:0000331] ##Evidence-Data-END##
1
61
121
181
241
301
361
421
481
541
601
661
721
781ATGCGGCTTG GGCTGTGTGT GGTGGCCCTG GTTCTGAGCT GGACACACCT CGCTGTGGGC
AGCCGGGGGA TCAAGGGCAA GAGACAGAGG CGGATCAGTG CTGAGGGGAG CCAATCTTGT
GCCAAGGGCT GTGAGCTCTG TTCAGAAGTC AACGGTTGCC TCAAATGCTC GCCCAAGCTC
TTCATTCTGC TGGAGAGGAA CGACATCCGC CAGGTGGGCG TCTGCCTGCC GTCCTGCCCG
CCTGGATACT TTGATGCCCG CAACCCCGAC ATGAACAAAT GCATCAAATG CAAGATTGAG
CACTGTGAGG CCTGCTTCAG CCACAACTTC TGCACCAAGT GTCAGGAGGG CTTGTACTTA
CACAAGGGCC GCTGCTATCC AGCCTGTCCC GAGGGTTCCA CAGCAGCCAA CAGCACCATG
GAGTGCGGCA GTCCTGCACA ATGTGAAATG AGCGAGTGGT CACCGTGGGG CCCCTGCTCC
AAGAAGAGGA AGCTGTGTGG TTTCCGGAAG GGATCGGAAG AGCGGACACG CAGGGTGCTC
CATGCTCCTG GAGGAGACCA AACCAACTGC TCAGACACCA AAGAGACCCG GAAGTGTACC
GTGCGCAGGA CGCCCTGCCC TGAGGGGCAG AAGAGGAAGA AGGCGAGCCA GGGCCGGAGG
GAGAATGCCA ATAGGCACCC GACCAGGAAG AACAGCAAGG AGCCAGGCTC CAACTCTCGG
AGACACAAAG GCCAGCAGCA GCCACAGCCA GGGACAGCAG GGCCACTCAC ATCAGTAGGC
CCCACCTAGThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_001101450.1 CDS 357..1145 Translation 
Target ORF information:
RefSeq Version NM_001107980.1 Organism Rattus norvegicus(Norway rat) Definition Rattus norvegicus R-spondin 1 (Rspo1), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_001107980.1
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781ATGCGGCTTG GGCTGTGTGT GGTGGCCCTG GTTCTGAGCT GGACACACCT CGCTGTGGGC
AGCCGGGGGA TCAAGGGCAA GAGACAGAGG CGGATCAGTG CTGAGGGGAG CCAATCTTGT
GCCAAGGGCT GTGAGCTCTG TTCAGAAGTC AACGGTTGCC TCAAATGCTC GCCCAAGCTC
TTCATTCTGC TGGAGAGGAA CGACATCCGC CAGGTGGGCG TCTGCCTGCC GTCCTGCCCG
CCTGGATACT TTGATGCCCG CAACCCCGAC ATGAACAAAT GCATCAAATG CAAGATTGAG
CACTGTGAGG CCTGCTTCAG CCACAACTTC TGCACCAAGT GTCAGGAGGG CTTGTACTTA
CACAAGGGCC GCTGCTATCC AGCCTGTCCC GAGGGTTCCA CAGCAGCCAA CAGCACCATG
GAGTGCGGCA GTCCTGCACA ATGTGAAATG AGCGAGTGGT CACCGTGGGG CCCCTGCTCC
AAGAAGAGGA AGCTGTGTGG TTTCCGGAAG GGATCGGAAG AGCGGACACG CAGGGTGCTC
CATGCTCCTG GAGGAGACCA AACCAACTGC TCAGACACCA AAGAGACCCG GAAGTGTACC
GTGCGCAGGA CGCCCTGCCC TGAGGGGCAG AAGAGGAAGA AGGCGAGCCA GGGCCGGAGG
GAGAATGCCA ATAGGCACCC GACCAGGAAG AACAGCAAGG AGCCAGGCTC CAACTCTCGG
AGACACAAAG GCCAGCAGCA GCCACAGCCA GGGACAGCAG GGCCACTCAC ATCAGTAGGC
CCCACCTAGThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID ORa12555 Clone ID Related Accession (Same CDS sequence) XM_008764019.2 , NM_001107980.1 Accession Version XM_008764019.2 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 789bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1469376000000 Organism Rattus norvegicus(Norway rat) Product R-spondin-1 isoform X1 Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005104.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008764019.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##
1
61
121
181
241
301
361
421
481
541
601
661
721
781ATGCGGCTTG GGCTGTGTGT GGTGGCCCTG GTTCTGAGCT GGACACACCT CGCTGTGGGC
AGCCGGGGGA TCAAGGGCAA GAGACAGAGG CGGATCAGTG CTGAGGGGAG CCAATCTTGT
GCCAAGGGCT GTGAGCTCTG TTCAGAAGTC AACGGTTGCC TCAAATGCTC GCCCAAGCTC
TTCATTCTGC TGGAGAGGAA CGACATCCGC CAGGTGGGCG TCTGCCTGCC GTCCTGCCCG
CCTGGATACT TTGATGCCCG CAACCCCGAC ATGAACAAAT GCATCAAATG CAAGATTGAG
CACTGTGAGG CCTGCTTCAG CCACAACTTC TGCACCAAGT GTCAGGAGGG CTTGTACTTA
CACAAGGGCC GCTGCTATCC AGCCTGTCCC GAGGGTTCCA CAGCAGCCAA CAGCACCATG
GAGTGCGGCA GTCCTGCACA ATGTGAAATG AGCGAGTGGT CACCGTGGGG CCCCTGCTCC
AAGAAGAGGA AGCTGTGTGG TTTCCGGAAG GGATCGGAAG AGCGGACACG CAGGGTGCTC
CATGCTCCTG GAGGAGACCA AACCAACTGC TCAGACACCA AAGAGACCCG GAAGTGTACC
GTGCGCAGGA CGCCCTGCCC TGAGGGGCAG AAGAGGAAGA AGGCGAGCCA GGGCCGGAGG
GAGAATGCCA ATAGGCACCC GACCAGGAAG AACAGCAAGG AGCCAGGCTC CAACTCTCGG
AGACACAAAG GCCAGCAGCA GCCACAGCCA GGGACAGCAG GGCCACTCAC ATCAGTAGGC
CCCACCTAGThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq XP_008762241.1 CDS 489..1277 Translation
Target ORF information:
RefSeq Version XM_008764019.2 Organism Rattus norvegicus(Norway rat) Definition Rattus norvegicus R-spondin 1 (Rspo1), transcript variant X1, mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK XM_008764019.2
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781ATGCGGCTTG GGCTGTGTGT GGTGGCCCTG GTTCTGAGCT GGACACACCT CGCTGTGGGC
AGCCGGGGGA TCAAGGGCAA GAGACAGAGG CGGATCAGTG CTGAGGGGAG CCAATCTTGT
GCCAAGGGCT GTGAGCTCTG TTCAGAAGTC AACGGTTGCC TCAAATGCTC GCCCAAGCTC
TTCATTCTGC TGGAGAGGAA CGACATCCGC CAGGTGGGCG TCTGCCTGCC GTCCTGCCCG
CCTGGATACT TTGATGCCCG CAACCCCGAC ATGAACAAAT GCATCAAATG CAAGATTGAG
CACTGTGAGG CCTGCTTCAG CCACAACTTC TGCACCAAGT GTCAGGAGGG CTTGTACTTA
CACAAGGGCC GCTGCTATCC AGCCTGTCCC GAGGGTTCCA CAGCAGCCAA CAGCACCATG
GAGTGCGGCA GTCCTGCACA ATGTGAAATG AGCGAGTGGT CACCGTGGGG CCCCTGCTCC
AAGAAGAGGA AGCTGTGTGG TTTCCGGAAG GGATCGGAAG AGCGGACACG CAGGGTGCTC
CATGCTCCTG GAGGAGACCA AACCAACTGC TCAGACACCA AAGAGACCCG GAAGTGTACC
GTGCGCAGGA CGCCCTGCCC TGAGGGGCAG AAGAGGAAGA AGGCGAGCCA GGGCCGGAGG
GAGAATGCCA ATAGGCACCC GACCAGGAAG AACAGCAAGG AGCCAGGCTC CAACTCTCGG
AGACACAAAG GCCAGCAGCA GCCACAGCCA GGGACAGCAG GGCCACTCAC ATCAGTAGGC
CCCACCTAGThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6.
Nature557(7706)564-569(2018 05)
Szenker-Ravi E,Altunoglu U,Leushacke M,Bosso-Lefèvre C,Khatoo M,Thi Tran H,Naert T,Noelanders R,Hajamohideen A,Beneteau C,de Sousa SB,Karaman B,Latypova X,Başaran S,Yücel EB,Tan TT,Vlaminck L,Nayak SS,Shukla A,Girisha KM,Le Caignec C,Soshnikova N,Uyguner ZO,Vleminckx K,Barker N,Kayserili H,Reversade B
LGR4 and its ligands, R-spondin 1 and R-spondin 3, regulate food intake in the hypothalamus of male rats.
Endocrinology155(2)429-40(2014 Feb)
Li JY,Chai B,Zhang W,Fritze DM,Zhang C,Mulholland MW
The complex world of WNT receptor signalling.
Nature reviews. Molecular cell biology13(12)767-79(2012 Dec)
Niehrs C
R-Spondin potentiates Wnt/β-catenin signaling through orphan receptors LGR4 and LGR5.
PloS one7(7)e40976(2012)
Ruffner H,Sprunger J,Charlat O,Leighton-Davies J,Grosshans B,Salathe A,Zietzling S,Beck V,Therier M,Isken A,Xie Y,Zhang Y,Hao H,Shi X,Liu D,Song Q,Clay I,Hintzen G,Tchorz J,Bouchez LC,Michaud G,Finan P,Myer VE,Bouwmeester T,Porter J,Hild M,Bassilana F,Parker CN,Cong F
LGR6 is a high affinity receptor of R-spondins and potentially functions as a tumor suppressor.
PloS one7(5)e37137(2012)
Gong X,Carmon KS,Lin Q,Thomas A,Yi J,Liu Q
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