Whrn cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Whrn
Entrez Gene ID	313255
Full Name	whirlin
Synonyms	Cip98,Dfnb31
General protein information	Preferred Names whirlin Names whirlin CASK-interacting protein CIP98 deafness, autosomal recessive 31
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 5 Map Location: 5q24
Summary	interacts with calmodulin-dependent serine kinase Cask; may play a a role in synaptic transmission [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_181088.1	NP_851602.1	whirlin

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	DFNB31	XP_005627013.1
Macaca mulatta (Rhesus monkey)	DFNB31	XP_001096493.2
Bos taurus (cattle)	DFNB31	XP_005210632.1
Mus musculus (house mouse)	Whrn	NP_001008793.1
Xenopus tropicalis (tropical clawed frog)	dfnb31	XP_004916786.1
Homo sapiens (human)	DFNB31	NP_056219.3
Gallus gallus (chicken)	DFNB31	XP_427028.4
Danio rerio (zebrafish)	LOC100334777	XP_002665968.3
Pan troglodytes (chimpanzee)	DFNB31	XP_001145880.3
Rattus norvegicus (Norway rat)	Dfnb31	NP_851602.1

Gene Ontology
Bibliography

Related articles in PubMed

Alternative Splice Forms Influence Functions of Whirlin in Mechanosensory Hair Cell Stereocilia.
Ebrahim S, Ingham NJ, Lewis MA, Rogers MJC, Cui R, Kachar B, Pass JC, Steel KP
Cell reports15(5)935-943(2016 05)

Whirlin increases TRPV1 channel expression and cellular stability.
Ciardo MG, Andrés-Bordería A, Cuesta N, Valente P, Camprubí-Robles M, Yang J, Planells-Cases R, Ferrer-Montiel A
Biochimica et biophysica acta1863(1)115-27(2016 Jan)

Whirlin and PDZ domain-containing 7 (PDZD7) proteins are both required to form the quaternary protein complex associated with Usher syndrome type 2.
Chen Q, Zou J, Shen Z, Zhang W, Yang J
The Journal of biological chemistry289(52)36070-88(2014 Dec)

Deletion of PDZD7 disrupts the Usher syndrome type 2 protein complex in cochlear hair cells and causes hearing loss in mice.
Zou J, Zheng T, Ren C, Askew C, Liu XP, Pan B, Holt JR, Wang Y, Yang J
Human molecular genetics23(9)2374-90(2014 May)

Whirlin, a cytoskeletal scaffolding protein, stabilizes the paranodal region and axonal cytoskeleton in myelinated axons.
Green JA, Yang J, Grati M, Kachar B, Bhat MA
BMC neuroscience1496(2013 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Whrn gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Whrn cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa04187	NM_181088.1 Latest version!	Rattus norvegicus whirlin (Whrn), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Whrn ( NM_181088.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_851602.1 Rattus norvegicus whirlin (Whrn), mRNA.

Price & Availability↑

CloneID	ORa04187
Clone ID Related Accession (Same CDS sequence)	NM_181088.1
Accession Version	NM_181088.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2763bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1568908800000
Organism	Rattus norvegicus(Norway rat)
Product	whirlin
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY227205.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY227205.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGAACGCAC AGCTGGACGG CCTGTCGGTG AGCTCGTCCT CCACCGGCTC GCTGGGCTCG 
GCGGCGGCGG CGGCGGGCGG CGGCGGGGGC GCGGGGCTGC GGCTGCTGTC TGCCAACGTG 
CGCCAGCTGC ACCAGGCGCT CACGGCGCTG CTGAGCGAGC CCGAGCGGGA GCAGTTCACT 
CACTGCCTCA ACGCGTACCA CGCGCGCCGC AACGTCTTCG ACCTGGTGCG CACCCTGCGC 
GTCCTGCTGG ACAGCCCGGT CAAGCGGCGT CTGCTGCCCA TGCTGCGTCT GGTCATCCCG 
CGCTCCGACC AGCTGCTCTT CGACCAGTAC ACGGCCGAGG GCCTCTACCT GCCCGCCACC 
ACCCCCTATA GGCAGCCCGC CTGGGCCGCT CCCGACGGCG CGGGGCCCGG GGAGGTGCGG 
CTCGTGAGCC TGCGACGCGC CAAGGCCCAC GAGGGCTTGG GCTTCAGCAT CCGCGGGGGC 
TCGGAGCACG GCGTGGGCAT CTACGTGTCT CTAGTGGAGC CAGGCTCCCT GGCAGAGAAG 
GAAGGGTTAC GGGTCGGGGA CCAGATTCTG CGCGTCAACG ATAAATCTCT AGCCCGGGTG 
ACCCACGCGG AGGCTGTCAA GGCTCTCAAG GGCTCCAAGA AGTTGGTGCT GTCTGTATAC 
TCAGCTGGGC GTATACCCGG GGGCTATGTC ACCAACCACA TCTACACCTG GGTGGACCCC 
CAGGGTCGAA GCACATCCCC TCCCTCCAGC CTTCCCCATG GCAGCACCCT GAGACAGCAT 
GAAGATGATC GAAGGAGTGC CCTACACCTC CTGCAGAGTG GAGATGAGAA AAAGGTGAAC 
CTGGTGCTGG GGGACGGCCG GTCCTTGGGC CTCACAATCC GAGGTGGAGC CGAGTACGGC 
CTTGGCATTT ACATCACTGG TGTGGACCCG GGCTCTGAAG CCGAAAGCAG CGGCCTCAAG 
GTTGGGGACC AGATTCTGGA GGTGAACGGG CGGAGCTTTC TCAGCATCCT GCATGACGAG 
GCAGTGAAGC TGCTCAAGTC ATCCCGGCAC CTCATCCTGA CCGTGAAGGA CGTCGGGAGG 
CTGCCCCACG CACGTACCAC CGTGGACCAG ACCAAGTGGA TCGCCAGTTC CCGGATCGGG 
GAAAGCATCA CCAACTCAGC AGGGTTTCCA GGGGACCTCA CAGAAGAAGG GACAAACAAG 
CCAGGATTTT ACAAGGGCCC AGCCGGCTCC CAAGTGACCC TGAGCAGCCT GGGGAATCAG 
ACACGTGCAC TGCTGGATGA CCAAGCCCGG CACCTGCTGA CAGAGCAGGA GCGTGCCACC 
ATGATGTACT ACCTAGACCA GTACCGTGGT GGCACCATCT CTGTGGAGGC CCTGGTCATG 
GCGCTGTTTG AGTTGCTCAA CACACATGCC AAGTTCTCAC TCCTGTCTGA GGTGAGAGGC 
ATCATCTCAC CCCAAGACCT GGACCGCTTC GACCACCTGG TGCTGAGGCG CGAGATCGAG 
TCCATGAAGG CGCGGCAGCC CCCAGGCCCT GGTGTCGGAG ACACCTATTC CATGGTATCC 
TACAGTGACA CCGGCTCATC CACAGGCAGC CATGGCACCT CTACAACCGT CAGCTCAGCC 
AGGGAGCGGC TGCTGTGGCT CATAGACCTG ATGGAGAATA CATTAGACCT GGAGGGAACC 
TGTGAGACTA CCCAAGGCAG CACCAACGCT CTCCCAGATG TGTCTGTGGA CGATGTCAGA 
TCTCCCTCGG AGGATCTGCC TGGCATCAAG CCACCTCCTC CCCCACCACC TCTGGCTCAA 
GGTCACGACC GCCTGCTTGG CCAGACTCGG AAGCCAGTGA GGGAGGACTC TGCACCTCTG 
TCTTCCGCTG CCCACTCAGG CATTGTCTTC TCAGCACCAC GGAATCGCAG CCCGCCGCCG 
CCGCCGGGCA TTGCACCCAC ACCCACTCCA GGACCTTCCT CAGCACGGGA CTCTCCCTCC 
TCCCCCATTT ACGCCTCCAT CTCCCATGCC AACCCCAGCT CCAGGAAGCC GCTGGACACC 
CACCTGGCCC TGGTTAACCA GCACCCCATC GGCCCCTTCC CTCGGGTCCA GTCCCCACCA 
CACCTGAAGA GTCCTCCTGC AGAGGCTCCA GGAGCTGGGG CCTGCCTTCC ACCGCCATCA 
CCCTCTGAAC ACGCTGACGC CATGGGCGCA AACCAGCACT TTGTCCTGGT GGAGGTGCAC 
CGTCCGGATA GTGAGCCGGA TGTGAACGAA GTGCGGGCTC TACCCCAGAC TCGCACAGCC 
TCCACACTCT CTCAGCTCTC AGACAGCGGG CAGACTCTAA GTGAGGACAG TGGCGTGGAT 
GCTGGAGAGA CAGAGGCCAG CACCTCAGGT CGAGGCAGAC AGACAGCAAA CACTAAGAAC 
AAGAATGGCA AGGAGCTTCC CCAGACGGAG AGGACCACAG AGGGTGCCAA CAAACCTCCT 
GGCCTGCTGG AGCCAACGTC CACCCTGATC CGTGTGAGGA AAAGCGCAGC CACACTGGGC 
ATCGCCATTG AGGGTGGTGC CAACACACGC CAGCCTCTGC CCAGGATCGT CACAATTCAG 
CGAGGAGGTT CTGCCCATAA CTGTGGGCAG CTCAAGGTGG GCCACGTGAT TCTGGAAGTG 
AACGGGCAGA CACTTCGGGG TAAGGAGCAC AGAGAGGCTG CCCGAGTCAT CGCTGAGGCC 
TTCAAGACCA AGGAGAGAGA CTACATCGAC TTTCTGGTCA CTGAGTTCAA CGTGATGCTC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_851602.1
CDS	1..2763
Translation	MNAQLDGLSVSSSSTGSLGSAAAAAGGGGGAGLRLLSANVRQLHQALTALLSEPEREQFTHCLNAYHARRNVFDLVRTLRVLLDSPVKRRLLPMLRLVIPRSDQLLFDQYTAEGLYLPATTPYRQPAWAAPDGAGPGEVRLVSLRRAKAHEGLGFSIRGGSEHGVGIYVSLVEPGSLAEKEGLRVGDQILRVNDKSLARVTHAEAVKALKGSKKLVLSVYSAGRIPGGYVTNHIYTWVDPQGRSTSPPSSLPHGSTLRQHEDDRRSALHLLQSGDEKKVNLVLGDGRSLGLTIRGGAEYGLGIYITGVDPGSEAESSGLKVGDQILEVNGRSFLSILHDEAVKLLKSSRHLILTVKDVGRLPHARTTVDQTKWIASSRIGESITNSAGFPGDLTEEGTNKPGFYKGPAGSQVTLSSLGNQTRALLDDQARHLLTEQERATMMYYLDQYRGGTISVEALVMALFELLNTHAKFSLLSEVRGIISPQDLDRFDHLVLRREIESMKARQPPGPGVGDTYSMVSYSDTGSSTGSHGTSTTVSSARERLLWLIDLMENTLDLEGTCETTQGSTNALPDVSVDDVRSPSEDLPGIKPPPPPPPLAQGHDRLLGQTRKPVREDSAPLSSAAHSGIVFSAPRNRSPPPPPGIAPTPTPGPSSARDSPSSPIYASISHANPSSRKPLDTHLALVNQHPIGPFPRVQSPPHLKSPPAEAPGAGACLPPPSPSEHADAMGANQHFVLVEVHRPDSEPDVNEVRALPQTRTASTLSQLSDSGQTLSEDSGVDAGETEASTSGRGRQTANTKNKNGKELPQTERTTEGANKPPGLLEPTSTLIRVRKSAATLGIAIEGGANTRQPLPRIVTIQRGGSAHNCGQLKVGHVILEVNGQTLRGKEHREAARVIAEAFKTKERDYIDFLVTEFNVML

Target ORF information:

RefSeq Version	NM_181088.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus whirlin (Whrn), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_181088.1

ORF Insert Sequence:

ATGAACGCAC AGCTGGACGG CCTGTCGGTG AGCTCGTCCT CCACCGGCTC GCTGGGCTCG 
GCGGCGGCGG CGGCGGGCGG CGGCGGGGGC GCGGGGCTGC GGCTGCTGTC TGCCAACGTG 
CGCCAGCTGC ACCAGGCGCT CACGGCGCTG CTGAGCGAGC CCGAGCGGGA GCAGTTCACT 
CACTGCCTCA ACGCGTACCA CGCGCGCCGC AACGTCTTCG ACCTGGTGCG CACCCTGCGC 
GTCCTGCTGG ACAGCCCGGT CAAGCGGCGT CTGCTGCCCA TGCTGCGTCT GGTCATCCCG 
CGCTCCGACC AGCTGCTCTT CGACCAGTAC ACGGCCGAGG GCCTCTACCT GCCCGCCACC 
ACCCCCTATA GGCAGCCCGC CTGGGCCGCT CCCGACGGCG CGGGGCCCGG GGAGGTGCGG 
CTCGTGAGCC TGCGACGCGC CAAGGCCCAC GAGGGCTTGG GCTTCAGCAT CCGCGGGGGC 
TCGGAGCACG GCGTGGGCAT CTACGTGTCT CTAGTGGAGC CAGGCTCCCT GGCAGAGAAG 
GAAGGGTTAC GGGTCGGGGA CCAGATTCTG CGCGTCAACG ATAAATCTCT AGCCCGGGTG 
ACCCACGCGG AGGCTGTCAA GGCTCTCAAG GGCTCCAAGA AGTTGGTGCT GTCTGTATAC 
TCAGCTGGGC GTATACCCGG GGGCTATGTC ACCAACCACA TCTACACCTG GGTGGACCCC 
CAGGGTCGAA GCACATCCCC TCCCTCCAGC CTTCCCCATG GCAGCACCCT GAGACAGCAT 
GAAGATGATC GAAGGAGTGC CCTACACCTC CTGCAGAGTG GAGATGAGAA AAAGGTGAAC 
CTGGTGCTGG GGGACGGCCG GTCCTTGGGC CTCACAATCC GAGGTGGAGC CGAGTACGGC 
CTTGGCATTT ACATCACTGG TGTGGACCCG GGCTCTGAAG CCGAAAGCAG CGGCCTCAAG 
GTTGGGGACC AGATTCTGGA GGTGAACGGG CGGAGCTTTC TCAGCATCCT GCATGACGAG 
GCAGTGAAGC TGCTCAAGTC ATCCCGGCAC CTCATCCTGA CCGTGAAGGA CGTCGGGAGG 
CTGCCCCACG CACGTACCAC CGTGGACCAG ACCAAGTGGA TCGCCAGTTC CCGGATCGGG 
GAAAGCATCA CCAACTCAGC AGGGTTTCCA GGGGACCTCA CAGAAGAAGG GACAAACAAG 
CCAGGATTTT ACAAGGGCCC AGCCGGCTCC CAAGTGACCC TGAGCAGCCT GGGGAATCAG 
ACACGTGCAC TGCTGGATGA CCAAGCCCGG CACCTGCTGA CAGAGCAGGA GCGTGCCACC 
ATGATGTACT ACCTAGACCA GTACCGTGGT GGCACCATCT CTGTGGAGGC CCTGGTCATG 
GCGCTGTTTG AGTTGCTCAA CACACATGCC AAGTTCTCAC TCCTGTCTGA GGTGAGAGGC 
ATCATCTCAC CCCAAGACCT GGACCGCTTC GACCACCTGG TGCTGAGGCG CGAGATCGAG 
TCCATGAAGG CGCGGCAGCC CCCAGGCCCT GGTGTCGGAG ACACCTATTC CATGGTATCC 
TACAGTGACA CCGGCTCATC CACAGGCAGC CATGGCACCT CTACAACCGT CAGCTCAGCC 
AGGGAGCGGC TGCTGTGGCT CATAGACCTG ATGGAGAATA CATTAGACCT GGAGGGAACC 
TGTGAGACTA CCCAAGGCAG CACCAACGCT CTCCCAGATG TGTCTGTGGA CGATGTCAGA 
TCTCCCTCGG AGGATCTGCC TGGCATCAAG CCACCTCCTC CCCCACCACC TCTGGCTCAA 
GGTCACGACC GCCTGCTTGG CCAGACTCGG AAGCCAGTGA GGGAGGACTC TGCACCTCTG 
TCTTCCGCTG CCCACTCAGG CATTGTCTTC TCAGCACCAC GGAATCGCAG CCCGCCGCCG 
CCGCCGGGCA TTGCACCCAC ACCCACTCCA GGACCTTCCT CAGCACGGGA CTCTCCCTCC 
TCCCCCATTT ACGCCTCCAT CTCCCATGCC AACCCCAGCT CCAGGAAGCC GCTGGACACC 
CACCTGGCCC TGGTTAACCA GCACCCCATC GGCCCCTTCC CTCGGGTCCA GTCCCCACCA 
CACCTGAAGA GTCCTCCTGC AGAGGCTCCA GGAGCTGGGG CCTGCCTTCC ACCGCCATCA 
CCCTCTGAAC ACGCTGACGC CATGGGCGCA AACCAGCACT TTGTCCTGGT GGAGGTGCAC 
CGTCCGGATA GTGAGCCGGA TGTGAACGAA GTGCGGGCTC TACCCCAGAC TCGCACAGCC 
TCCACACTCT CTCAGCTCTC AGACAGCGGG CAGACTCTAA GTGAGGACAG TGGCGTGGAT 
GCTGGAGAGA CAGAGGCCAG CACCTCAGGT CGAGGCAGAC AGACAGCAAA CACTAAGAAC 
AAGAATGGCA AGGAGCTTCC CCAGACGGAG AGGACCACAG AGGGTGCCAA CAAACCTCCT 
GGCCTGCTGG AGCCAACGTC CACCCTGATC CGTGTGAGGA AAAGCGCAGC CACACTGGGC 
ATCGCCATTG AGGGTGGTGC CAACACACGC CAGCCTCTGC CCAGGATCGT CACAATTCAG 
CGAGGAGGTT CTGCCCATAA CTGTGGGCAG CTCAAGGTGG GCCACGTGAT TCTGGAAGTG 
AACGGGCAGA CACTTCGGGG TAAGGAGCAC AGAGAGGCTG CCCGAGTCAT CGCTGAGGCC 
TTCAAGACCA AGGAGAGAGA CTACATCGAC TTTCTGGTCA CTGAGTTCAA CGTGATGCTC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Alternative Splice Forms Influence Functions of Whirlin in Mechanosensory Hair Cell Stereocilia.
Cell reports15(5)935-943(2016 05)
Ebrahim S,Ingham NJ,Lewis MA,Rogers MJC,Cui R,Kachar B,Pass JC,Steel KP

Whirlin increases TRPV1 channel expression and cellular stability.
Biochimica et biophysica acta1863(1)115-27(2016 Jan)
Ciardo MG,Andrés-Bordería A,Cuesta N,Valente P,Camprubí-Robles M,Yang J,Planells-Cases R,Ferrer-Montiel A

Whirlin and PDZ domain-containing 7 (PDZD7) proteins are both required to form the quaternary protein complex associated with Usher syndrome type 2.
The Journal of biological chemistry289(52)36070-88(2014 Dec)
Chen Q,Zou J,Shen Z,Zhang W,Yang J

Deletion of PDZD7 disrupts the Usher syndrome type 2 protein complex in cochlear hair cells and causes hearing loss in mice.
Human molecular genetics23(9)2374-90(2014 May)
Zou J,Zheng T,Ren C,Askew C,Liu XP,Pan B,Holt JR,Wang Y,Yang J

Whirlin, a cytoskeletal scaffolding protein, stabilizes the paranodal region and axonal cytoskeleton in myelinated axons.
BMC neuroscience1496(2013 Sep)
Green JA,Yang J,Grati M,Kachar B,Bhat MA