Fan1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fan1
Entrez Gene ID	309256
Full Name	FANCD2 and FANCI associated nuclease 1
Synonyms	Mtmr15,RGD1566323
General protein information	Preferred Names FANCD2 and FANCI associated nuclease 1 Names fanconi-associated nuclease 1 FANCD2/FANCI-associated nuclease 1 coiled-coil domain-containing protein MTMR15 myotubularin related protein 15
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q22

mRNA and Protein(s)

mRNA	Protein	Name
XM_008759539.2	XP_008757761.1	fanconi-associated nuclease 1 isoform X2
XM_006229339.3	XP_006229401.1	fanconi-associated nuclease 1 isoform X1
NM_001191633.1	NP_001178562.1	fanconi-associated nuclease 1

Pathways from BioSystems

Homologies

Neurospora crassa	NCU03036	XP_964041.2
Bos taurus (cattle)	FAN1	NP_001158142.1
Rattus norvegicus (Norway rat)	Fan1	NP_001178562.1
Danio rerio (zebrafish)	fan1	NP_001038546.2
Caenorhabditis elegans (roundworm)	fan-1	NP_500997.1
Pan troglodytes (chimpanzee)	FAN1	XP_510266.2
Canis lupus familiaris (dog)	FAN1	XP_005618326.1
Gallus gallus (chicken)	FAN1	XP_004943817.1
Magnaporthe oryzae (rice blast fungus)	MGG_00351	XP_003718732.1
Homo sapiens (human)	FAN1	NP_055782.3
Schizosaccharomyces pombe (fission yeast)	SPBC146.06c	NP_595395.1
Macaca mulatta (Rhesus monkey)	FAN1	XP_001109813.1
Mus musculus (house mouse)	Fan1	NP_808561.2
Xenopus tropicalis (tropical clawed frog)	fan1	XP_002934961.2

Gene Ontology
Bibliography

Related articles in PubMed

DNA repair. Mechanism of DNA interstrand cross-link processing by repair nuclease FAN1.
Wang R, Persky NS, Yoo B, Ouerfelli O, Smogorzewska A, Elledge SJ, Pavletich NP
Science (New York, N.Y.)346(6213)1127-30(2014 Nov)

FAN1 activity on asymmetric repair intermediates is mediated by an atypical monomeric virus-type replication-repair nuclease domain.
Pennell S, Déclais AC, Li J, Haire LF, Berg W, Saldanha JW, Taylor IA, Rouse J, Lilley DM, Smerdon SJ
Cell reports8(1)84-93(2014 Jul)

A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair.
Smogorzewska A, Desetty R, Saito TT, Schlabach M, Lach FP, Sowa ME, Clark AB, Kunkel TA, Harper JW, Colaiácovo MP, Elledge SJ
Molecular cell39(1)36-47(2010 Jul)

Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agents.
Kratz K, Schöpf B, Kaden S, Sendoel A, Eberhard R, Lademann C, Cannavó E, Sartori AA, Hengartner MO, Jiricny J
Cell142(1)77-88(2010 Jul)

Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2.
MacKay C, Déclais AC, Lundin C, Agostinho A, Deans AJ, MacArtney TJ, Hofmann K, Gartner A, West SC, Helleday T, Lilley DM, Rouse J
Cell142(1)65-76(2010 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Fan1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fan1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa22882	XM_008759539.2 Latest version!	Rattus norvegicus FANCD2/FANCI-associated nuclease 1 (Fan1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00
ORa07283	NM_001191633.1 Latest version!	Rattus norvegicus FANCD2 and FANCI associated nuclease 1 (Fan1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$559.30 $799.00
ORa07283	XM_006229339.3 Latest version!	Rattus norvegicus FANCD2/FANCI-associated nuclease 1 (Fan1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$559.30 $799.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fan1 ( XM_008759539.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008757761.1 Rattus norvegicus FANCD2/FANCI-associated nuclease 1 (Fan1), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa22882
Clone ID Related Accession (Same CDS sequence)	XM_008759539.2
Accession Version	XM_008759539.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2898bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	fanconi-associated nuclease 1 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008759539.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATGTCAC AAAAGAGCTC ACCTGCTCAA AAAAGACCCC GTAAAAGCTT ATCTACCGGC 
AAAACTACGA AAAGCCAATC TCATTCCATT ACTTCGTATT TTAACAGTGT ACCACCTGCT 
AAACTTGCAT GTTCAATTTG TCATAAAATG GTGCCCAGGT ATGACTTAAT CCGGCACCTT 
GATGAGTCTT GTGCTAACAA TGGTGAAATC GTTCAAAATG AGCCTGCTCA GGCTGGTTTA 
ATTAACTCAA CTGTGCCTAC ATCAGATTTA CCCAGTACTC CTTTAGAAGA TATGACACCT 
CAGAAGTTAT CACCACCAAA GAGACGTTTA ATCTCTGCCC AGTGTGGTTC AAAACTGGGC 
GTGCGACAGC AGACCAGTCC CTACTTTAAA AAAGCCTTGG TGTGCAAAAA TCAAAATAAG 
CTTCCAAATC AGAGTGTGGA AATCAGGTCT TTGGGAAGTC TGTCATCAAA ACTGTCCAGA 
AGGTACGTAA AAGCTAAAAA ATCACTCTCT AAGAACGAGG GGCTAGCCAG TCATTGCCCA 
CCGACTTCTC CGTCCCCACC TGGCCCCAGC CTGGTTGATA ACTGTCCAGA GATGGACAAC 
AAAGATGAGA TTTTAAACAG TTCCCAGAAG GAAAACATTT ACTCGTGTGC ACCTCTAGAG 
GAAGAGACCG CTTCAGAACA GAAGGTAAAG AGCAGTAAAA GGATGGGAGA TGGAAGTCAG 
AAAGCTTCCG GTGGGGAGCC GGCCCTCACG CCTGCATCCC CAGAGCAGGC CCCCACATTA 
CTGTCCTCAG ACTTAACTCT TGTCAATAAC ACGGATTCCT CTTCGGGAGA TGCTCTCGAA 
CAAGAAGGTG CTGGAAGGGT AGGTGTAGGG GTTGATGAAC AGCTTGCGGC ATGCAGCCAT 
GAAGAAGTAC AAATGACTGT TGATGCTGAG GTGGGAACGC TGGTGTCAGG GGGGGCGGAA 
TCAAACAGTC CTGCTGACAA CGACGACGAT GACGCATCTA CATGGAGTAA CAACCCAGAG 
CTTAGGGAAG CTGGCAGTGC CTTAAAGAGA CAAAGGGCTT GCAGTCCTCT GGAGCAGGGC 
GCCAGTTGTG TTCCCAGTGT GACAGCTCAA CCCCAACCGA GTCACCCGTA CTACCTGAGG 
AGCTTCCTGG TGGTTCTGCA GGCCATCCTT GAGAACGAAG AGGACATGAA GCTCTTCGAT 
GACCAGGAGA AGGGCGTTAT AGCTAAGTTT TACCAGCTGT CAGCCAGTGG TCAGAAGTTG 
TATGTGAGGC TCTTCCAACG TAAATTAACC TGGATTAAAG TGAGTAAACT GGAGTATGAA 
GAGATTGCCT CGGACTTAAC CCCTGTGGTT GAAGAATTGA AGAACTTAGG CTTTCTACAG 
ACAGAATCTG AGTTGCAAGA ACTCTCTGAT GTACTTGAAC TCCTTTCTGC TCCTGAGCTG 
AAAGCCCTGG CCAAAACCTT CCACTTGGTG AGTCCCGGTG GGCAGAAGCA GCAGCTGGTA 
GACGCCTTCC TCAAACTGGC CAGACAGCGC TCAGTCTACA CTTGGGGCAA GACTCAGCCT 
GGAATCAGAG CGGTGATTTT AAAGAGAGCT AAAGACTTGG CTGGCCCGTC CCTTCGAGTC 
TGTAAAGGCC CTAGGGCTGT GTTTTGCCGC CTCCTGCTTC TGTTCTCGTT GACTGATACC 
ATGGAAGACG AAGAAGCTGC GTGTGGGGGT CAAGGTCAGC TGTCTACTGT GCTATTGGTC 
AATCTGGGCC GAATGGAGTT TCCTCAGTAC AGCATCAGCC GGAAGACCCA GATCTTCAGG 
GACAGAGAGG ATCTTATCAG ATACGCAGCC GCCGCGCACA TGCTGAGTGA CATCTCAGCT 
GCCATGGCCA GTGGGAACTG GGAAGAAGCT AAGGAGCTTT CTCAGATTGC AAAGAGAGAC 
TGGGACCAAC TGAAAAGCCA CCCTTCCCTG AGATACCACG AGGCCTTGCC ACTCTTTCTG 
CGCTGTTTTA CTGTTGGGTG GATCTACACA AGGATTTCCT CTCGGGCTGT TGAAGTACTA 
GAGAGACTTC ACATGTACGA GGAAGCTGTC AAGGAACTTG AAAACCTCCT CGCTCAGAAA 
GTCTATTGTC CTGACAGCAG AGGCCGCTGG TGGGACCGCC TGGCTCTTAA CCTGCACCAG 
CACCTGAAGC GTCTGGAAGA GGTGACCATC ACAGGCAGGC TGTGCCCACA GCATGGGATG 
GGCAAGTCTG TGTTTGTCAT TGAGGGTGGA GACCCCACCA ACCCCACCAC AATCCTGTGT 
TCTGTGGAGG AACTGGCACT GGACTATTAC AGGCGGAGTG GCTTTGACCA AGGGATTCAC 
GGAGAAGGGT CCACCTTCAG CACCCTGTGT GGCCTCCTGC TGTGGGATAT CATCTTCATG 
GATGGAATAC CAGATGTCTT CAGAAATGCC TACCAGGCCT CCCCCCTGGA TTTGCTCACA 
GACAGCTTCT TCTCAAGCAG GGAGCAGGCC CTGGAAGCCA GGCTGCAGCT GATCCACAGC 
GCCCCTGCTG AGAGCCTGCG GGCCTGGGTG ACTGAAGCAT GGCAGGCCCA GCAAGGCAGG 
GCGGCTTCTC TGGTCAGCTG GGATCGCTTC ACTTCCCTTC AGCAAGCTCA GGACCTTGTC 
TCCTGCCTCG GGGGTCCTGT CCTCAGCGGT GTGTGCAGGC GCCTGGCTGC TGACTTTCGG 
CACTGCCGAG GAGGCCTCCC TGATTTGGTG GTGTGGAATT CTCAGAGCCA CCATTGCAAG 
CTGGTGGAAG TTAAAGGCCC CAGTGATCGC CTGTCATGTA AGCAGATGAT CTGGCTGGAT 
GAACTACAAA AGCTGGGGGC AGACGTAGAA GTATGCCATG TGGTTGCAGT TGGTGCTAAG 
AGCAAAGGTC TTGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008757761.1
CDS	612..3509
Translation	MMSQKSSPAQKRPRKSLSTGKTTKSQSHSITSYFNSVPPAKLACSICHKMVPRYDLIRHLDESCANNGEIVQNEPAQAGLINSTVPTSDLPSTPLEDMTPQKLSPPKRRLISAQCGSKLGVRQQTSPYFKKALVCKNQNKLPNQSVEIRSLGSLSSKLSRRYVKAKKSLSKNEGLASHCPPTSPSPPGPSLVDNCPEMDNKDEILNSSQKENIYSCAPLEEETASEQKVKSSKRMGDGSQKASGGEPALTPASPEQAPTLLSSDLTLVNNTDSSSGDALEQEGAGRVGVGVDEQLAACSHEEVQMTVDAEVGTLVSGGAESNSPADNDDDDASTWSNNPELREAGSALKRQRACSPLEQGASCVPSVTAQPQPSHPYYLRSFLVVLQAILENEEDMKLFDDQEKGVIAKFYQLSASGQKLYVRLFQRKLTWIKVSKLEYEEIASDLTPVVEELKNLGFLQTESELQELSDVLELLSAPELKALAKTFHLVSPGGQKQQLVDAFLKLARQRSVYTWGKTQPGIRAVILKRAKDLAGPSLRVCKGPRAVFCRLLLLFSLTDTMEDEEAACGGQGQLSTVLLVNLGRMEFPQYSISRKTQIFRDREDLIRYAAAAHMLSDISAAMASGNWEEAKELSQIAKRDWDQLKSHPSLRYHEALPLFLRCFTVGWIYTRISSRAVEVLERLHMYEEAVKELENLLAQKVYCPDSRGRWWDRLALNLHQHLKRLEEVTITGRLCPQHGMGKSVFVIEGGDPTNPTTILCSVEELALDYYRRSGFDQGIHGEGSTFSTLCGLLLWDIIFMDGIPDVFRNAYQASPLDLLTDSFFSSREQALEARLQLIHSAPAESLRAWVTEAWQAQQGRAASLVSWDRFTSLQQAQDLVSCLGGPVLSGVCRRLAADFRHCRGGLPDLVVWNSQSHHCKLVEVKGPSDRLSCKQMIWLDELQKLGADVEVCHVVAVGAKSKGLG

Target ORF information:

RefSeq Version	XM_008759539.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus FANCD2/FANCI-associated nuclease 1 (Fan1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008759539.2

ORF Insert Sequence:

ATGATGTCAC AAAAGAGCTC ACCTGCTCAA AAAAGACCCC GTAAAAGCTT ATCTACCGGC 
AAAACTACGA AAAGCCAATC TCATTCCATT ACTTCGTATT TTAACAGTGT ACCACCTGCT 
AAACTTGCAT GTTCAATTTG TCATAAAATG GTGCCCAGGT ATGACTTAAT CCGGCACCTT 
GATGAGTCTT GTGCTAACAA TGGTGAAATC GTTCAAAATG AGCCTGCTCA GGCTGGTTTA 
ATTAACTCAA CTGTGCCTAC ATCAGATTTA CCCAGTACTC CTTTAGAAGA TATGACACCT 
CAGAAGTTAT CACCACCAAA GAGACGTTTA ATCTCTGCCC AGTGTGGTTC AAAACTGGGC 
GTGCGACAGC AGACCAGTCC CTACTTTAAA AAAGCCTTGG TGTGCAAAAA TCAAAATAAG 
CTTCCAAATC AGAGTGTGGA AATCAGGTCT TTGGGAAGTC TGTCATCAAA ACTGTCCAGA 
AGGTACGTAA AAGCTAAAAA ATCACTCTCT AAGAACGAGG GGCTAGCCAG TCATTGCCCA 
CCGACTTCTC CGTCCCCACC TGGCCCCAGC CTGGTTGATA ACTGTCCAGA GATGGACAAC 
AAAGATGAGA TTTTAAACAG TTCCCAGAAG GAAAACATTT ACTCGTGTGC ACCTCTAGAG 
GAAGAGACCG CTTCAGAACA GAAGGTAAAG AGCAGTAAAA GGATGGGAGA TGGAAGTCAG 
AAAGCTTCCG GTGGGGAGCC GGCCCTCACG CCTGCATCCC CAGAGCAGGC CCCCACATTA 
CTGTCCTCAG ACTTAACTCT TGTCAATAAC ACGGATTCCT CTTCGGGAGA TGCTCTCGAA 
CAAGAAGGTG CTGGAAGGGT AGGTGTAGGG GTTGATGAAC AGCTTGCGGC ATGCAGCCAT 
GAAGAAGTAC AAATGACTGT TGATGCTGAG GTGGGAACGC TGGTGTCAGG GGGGGCGGAA 
TCAAACAGTC CTGCTGACAA CGACGACGAT GACGCATCTA CATGGAGTAA CAACCCAGAG 
CTTAGGGAAG CTGGCAGTGC CTTAAAGAGA CAAAGGGCTT GCAGTCCTCT GGAGCAGGGC 
GCCAGTTGTG TTCCCAGTGT GACAGCTCAA CCCCAACCGA GTCACCCGTA CTACCTGAGG 
AGCTTCCTGG TGGTTCTGCA GGCCATCCTT GAGAACGAAG AGGACATGAA GCTCTTCGAT 
GACCAGGAGA AGGGCGTTAT AGCTAAGTTT TACCAGCTGT CAGCCAGTGG TCAGAAGTTG 
TATGTGAGGC TCTTCCAACG TAAATTAACC TGGATTAAAG TGAGTAAACT GGAGTATGAA 
GAGATTGCCT CGGACTTAAC CCCTGTGGTT GAAGAATTGA AGAACTTAGG CTTTCTACAG 
ACAGAATCTG AGTTGCAAGA ACTCTCTGAT GTACTTGAAC TCCTTTCTGC TCCTGAGCTG 
AAAGCCCTGG CCAAAACCTT CCACTTGGTG AGTCCCGGTG GGCAGAAGCA GCAGCTGGTA 
GACGCCTTCC TCAAACTGGC CAGACAGCGC TCAGTCTACA CTTGGGGCAA GACTCAGCCT 
GGAATCAGAG CGGTGATTTT AAAGAGAGCT AAAGACTTGG CTGGCCCGTC CCTTCGAGTC 
TGTAAAGGCC CTAGGGCTGT GTTTTGCCGC CTCCTGCTTC TGTTCTCGTT GACTGATACC 
ATGGAAGACG AAGAAGCTGC GTGTGGGGGT CAAGGTCAGC TGTCTACTGT GCTATTGGTC 
AATCTGGGCC GAATGGAGTT TCCTCAGTAC AGCATCAGCC GGAAGACCCA GATCTTCAGG 
GACAGAGAGG ATCTTATCAG ATACGCAGCC GCCGCGCACA TGCTGAGTGA CATCTCAGCT 
GCCATGGCCA GTGGGAACTG GGAAGAAGCT AAGGAGCTTT CTCAGATTGC AAAGAGAGAC 
TGGGACCAAC TGAAAAGCCA CCCTTCCCTG AGATACCACG AGGCCTTGCC ACTCTTTCTG 
CGCTGTTTTA CTGTTGGGTG GATCTACACA AGGATTTCCT CTCGGGCTGT TGAAGTACTA 
GAGAGACTTC ACATGTACGA GGAAGCTGTC AAGGAACTTG AAAACCTCCT CGCTCAGAAA 
GTCTATTGTC CTGACAGCAG AGGCCGCTGG TGGGACCGCC TGGCTCTTAA CCTGCACCAG 
CACCTGAAGC GTCTGGAAGA GGTGACCATC ACAGGCAGGC TGTGCCCACA GCATGGGATG 
GGCAAGTCTG TGTTTGTCAT TGAGGGTGGA GACCCCACCA ACCCCACCAC AATCCTGTGT 
TCTGTGGAGG AACTGGCACT GGACTATTAC AGGCGGAGTG GCTTTGACCA AGGGATTCAC 
GGAGAAGGGT CCACCTTCAG CACCCTGTGT GGCCTCCTGC TGTGGGATAT CATCTTCATG 
GATGGAATAC CAGATGTCTT CAGAAATGCC TACCAGGCCT CCCCCCTGGA TTTGCTCACA 
GACAGCTTCT TCTCAAGCAG GGAGCAGGCC CTGGAAGCCA GGCTGCAGCT GATCCACAGC 
GCCCCTGCTG AGAGCCTGCG GGCCTGGGTG ACTGAAGCAT GGCAGGCCCA GCAAGGCAGG 
GCGGCTTCTC TGGTCAGCTG GGATCGCTTC ACTTCCCTTC AGCAAGCTCA GGACCTTGTC 
TCCTGCCTCG GGGGTCCTGT CCTCAGCGGT GTGTGCAGGC GCCTGGCTGC TGACTTTCGG 
CACTGCCGAG GAGGCCTCCC TGATTTGGTG GTGTGGAATT CTCAGAGCCA CCATTGCAAG 
CTGGTGGAAG TTAAAGGCCC CAGTGATCGC CTGTCATGTA AGCAGATGAT CTGGCTGGAT 
GAACTACAAA AGCTGGGGGC AGACGTAGAA GTATGCCATG TGGTTGCAGT TGGTGCTAAG 
AGCAAAGGTC TTGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Fan1 ( NM_001191633.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001178562.1 Rattus norvegicus FANCD2 and FANCI associated nuclease 1 (Fan1), mRNA.

Price & Availability↑

CloneID	ORa07283
Clone ID Related Accession (Same CDS sequence)	XM_006229339.3 , NM_001191633.1
Accession Version	NM_001191633.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3063bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1527696000000
Organism	Rattus norvegicus(Norway rat)
Product	fanconi-associated nuclease 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AABR07004102.1. On Jul 17, 2010 this sequence version replaced XM_219706.5. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGATGTCAC AAAAGAGCTC ACCTGCTCAA AAAAGACCCC GTAAAAGCTT ATCTACCGGC 
AAAACTACGA AAAGCCAATC TCATTCCATT ACTTCGTATT TTAACAGTGT ACCACCTGCT 
AAACTTGCAT GTTCAATTTG TCATAAAATG GTGCCCAGGT ATGACTTAAT CCGGCACCTT 
GATGAGTCTT GTGCTAACAA TGGTGAAATC GTTCAAAATG AGCCTGCTCA GGCTGGTTTA 
ATTAACTCAA CTGTGCCTAC ATCAGATTTA CCCAGTACTC CTTTAGAAGA TATGACACCT 
CAGAAGTTAT CACCACCAAA GAGACGTTTA ATCTCTGCCC AGTGTGGTTC AAAACTGGGC 
GTGCGACAGC AGACCAGTCC CTACTTTAAA AAAGCCTTGG TGTGCAAAAA TCAAAATAAG 
CTTCCAAATC AGAGTGTGGA AATCAGGTCT TTGGGAAGTC TGTCATCAAA ACTGTCCAGA 
AGGTACGTAA AAGCTAAAAA ATCACTCTCT AAGAACGAGG GGCTAGCCAG TCATTGCCCA 
CCGACTTCTC CGTCCCCACC TGGCCCCAGC CTGGTTGATA ACTGTCCAGA GATGGACAAC 
AAAGATGAGA TTTTAAACAG TTCCCAGAAG GAAAACATTT ACTCGTGTGC ACCTCTAGAG 
GAAGAGACCG CTTCAGAACA GAAGGTAAAG AGCAGTAAAA GGATGGGAGA TGGAAGTCAG 
AAAGCTTCCG GTGGGGAGCC GGCCCTCACG CCTGCATCCC CAGAGCAGGC CCCCACATTA 
CTGTCCTCAG ACTTAACTCT TGTCAATAAC ACGGATTCCT CTTCGGGAGA TGCTCTCGAA 
CAAGAAGGTG CTGGAAGGGT AGGTGTAGGG GTTGATGAAC AGCTTGCGGC ATGCAGCCAT 
GAAGAAGTAC AAATGACTGT TGATGCTGAG GTGGGAACGC TGGTGTCAGG GGGGGCGGAA 
TCAAACAGTC CTGCTGACAA CGACGACGAT GACGCATCTA CATGGAGTAA CAACCCAGAG 
CTTAGGGAAG CTGGCAGTGC CTTAAAGAGA CAAAGGGCTT GCAGTCCTCT GGAGCAGGGC 
GCCAGTTGTG TTCCCAGTGT GACAGCTCAA CCCCAACCGA GTCACCCGTA CTACCTGAGG 
AGCTTCCTGG TGGTTCTGCA GGCCATCCTT GAGAACGAAG AGGACATGAA GCTCTTCGAT 
GACCAGGAGA AGGGCGTTAT AGCTAAGTTT TACCAGCTGT CAGCCAGTGG TCAGAAGTTG 
TATGTGAGGC TCTTCCAACG TAAATTAACC TGGATTAAAG TGAGTAAACT GGAGTATGAA 
GAGATTGCCT CGGACTTAAC CCCTGTGGTT GAAGAATTGA AGAACTTAGG CTTTCTACAG 
ACAGAATCTG AGTTGCAAGA ACTCTCTGAT GTACTTGAAC TCCTTTCTGC TCCTGAGCTG 
AAAGCCCTGG CCAAAACCTT CCACTTGGTG AGTCCCGGTG GGCAGAAGCA GCAGCTGGTA 
GACGCCTTCC TCAAACTGGC CAGACAGCGC TCAGTCTACA CTTGGGGCAA GACTCAGCCT 
GGAATCAGAG CGGTGATTTT AAAGAGAGCT AAAGACTTGG CTGGCCCGTC CCTTCGAGTC 
TGTAAAGGCC CTAGGGCTGT GTTTTGCCGC CTCCTGCTTC TGTTCTCGTT GACTGATACC 
ATGGAAGACG AAGAAGCTGC GTGTGGGGGT CAAGGTCAGC TGTCTACTGT GCTATTGGTC 
AATCTGGGCC GAATGGAGTT TCCTCAGTAC AGCATCAGCC GGAAGACCCA GATCTTCAGG 
GACAGAGAGG ATCTTATCAG ATACGCAGCC GCCGCGCACA TGCTGAGTGA CATCTCAGCT 
GCCATGGCCA GTGGGAACTG GGAAGAAGCT AAGGAGCTTT CTCAGATTGC AAAGAGAGAC 
TGGGACCAAC TGAAAAGCCA CCCTTCCCTG AGATACCACG AGGCCTTGCC ACTCTTTCTG 
CGCTGTTTTA CTGTTGGGTG GATCTACACA AGGATTTCCT CTCGGGCTGT TGAAGTACTA 
GAGAGACTTC ACATGTACGA GGAAGCTGTC AAGGAACTTG AAAACCTCCT CGCTCAGAAA 
GTCTATTGTC CTGACAGCAG AGGCCGCTGG TGGGACCGCC TGGCTCTTAA CCTGCACCAG 
CACCTGAAGC GTCTGGAAGA GGCAATTTGG TGCATCAAGG AAGGCCTGGC AGATCCACAA 
GTGAGGACAG GACACCGACT TTCTCTTTAT CAGCGAGCTG TGCGCCTTCG AGAGTCTCCG 
AGCTGTAAAA AGTACAGGCA CCTATTCAGC CAGCTGCCAG AAGTCACTGT GGGAGACGTT 
AAGCATGTGA CCATCACAGG CAGGCTGTGC CCACAGCATG GGATGGGCAA GTCTGTGTTT 
GTCATTGAGG GTGGAGACCC CACCAACCCC ACCACAATCC TGTGTTCTGT GGAGGAACTG 
GCACTGGACT ATTACAGGCG GAGTGGCTTT GACCAAGGGA TTCACGGAGA AGGGTCCACC 
TTCAGCACCC TGTGTGGCCT CCTGCTGTGG GATATCATCT TCATGGATGG AATACCAGAT 
GTCTTCAGAA ATGCCTACCA GGCCTCCCCC CTGGATTTGC TCACAGACAG CTTCTTCTCA 
AGCAGGGAGC AGGCCCTGGA AGCCAGGCTG CAGCTGATCC ACAGCGCCCC TGCTGAGAGC 
CTGCGGGCCT GGGTGACTGA AGCATGGCAG GCCCAGCAAG GCAGGGCGGC TTCTCTGGTC 
AGCTGGGATC GCTTCACTTC CCTTCAGCAA GCTCAGGACC TTGTCTCCTG CCTCGGGGGT 
CCTGTCCTCA GCGGTGTGTG CAGGCGCCTG GCTGCTGACT TTCGGCACTG CCGAGGAGGC 
CTCCCTGATT TGGTGGTGTG GAATTCTCAG AGCCACCATT GCAAGCTGGT GGAAGTTAAA 
GGCCCCAGTG ATCGCCTGTC ATGTAAGCAG ATGATCTGGC TGGATGAACT ACAAAAGCTG 
GGGGCAGACG TAGAAGTATG CCATGTGGTT GCAGTTGGTG CTAAGAGCAA AGGTCTTGGC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001178562.1
CDS	1..3063
Translation	MMSQKSSPAQKRPRKSLSTGKTTKSQSHSITSYFNSVPPAKLACSICHKMVPRYDLIRHLDESCANNGEIVQNEPAQAGLINSTVPTSDLPSTPLEDMTPQKLSPPKRRLISAQCGSKLGVRQQTSPYFKKALVCKNQNKLPNQSVEIRSLGSLSSKLSRRYVKAKKSLSKNEGLASHCPPTSPSPPGPSLVDNCPEMDNKDEILNSSQKENIYSCAPLEEETASEQKVKSSKRMGDGSQKASGGEPALTPASPEQAPTLLSSDLTLVNNTDSSSGDALEQEGAGRVGVGVDEQLAACSHEEVQMTVDAEVGTLVSGGAESNSPADNDDDDASTWSNNPELREAGSALKRQRACSPLEQGASCVPSVTAQPQPSHPYYLRSFLVVLQAILENEEDMKLFDDQEKGVIAKFYQLSASGQKLYVRLFQRKLTWIKVSKLEYEEIASDLTPVVEELKNLGFLQTESELQELSDVLELLSAPELKALAKTFHLVSPGGQKQQLVDAFLKLARQRSVYTWGKTQPGIRAVILKRAKDLAGPSLRVCKGPRAVFCRLLLLFSLTDTMEDEEAACGGQGQLSTVLLVNLGRMEFPQYSISRKTQIFRDREDLIRYAAAAHMLSDISAAMASGNWEEAKELSQIAKRDWDQLKSHPSLRYHEALPLFLRCFTVGWIYTRISSRAVEVLERLHMYEEAVKELENLLAQKVYCPDSRGRWWDRLALNLHQHLKRLEEAIWCIKEGLADPQVRTGHRLSLYQRAVRLRESPSCKKYRHLFSQLPEVTVGDVKHVTITGRLCPQHGMGKSVFVIEGGDPTNPTTILCSVEELALDYYRRSGFDQGIHGEGSTFSTLCGLLLWDIIFMDGIPDVFRNAYQASPLDLLTDSFFSSREQALEARLQLIHSAPAESLRAWVTEAWQAQQGRAASLVSWDRFTSLQQAQDLVSCLGGPVLSGVCRRLAADFRHCRGGLPDLVVWNSQSHHCKLVEVKGPSDRLSCKQMIWLDELQKLGADVEVCHVVAVGAKSKGLG

Target ORF information:

RefSeq Version	NM_001191633.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus FANCD2 and FANCI associated nuclease 1 (Fan1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001191633.1

ORF Insert Sequence:

ATGATGTCAC AAAAGAGCTC ACCTGCTCAA AAAAGACCCC GTAAAAGCTT ATCTACCGGC 
AAAACTACGA AAAGCCAATC TCATTCCATT ACTTCGTATT TTAACAGTGT ACCACCTGCT 
AAACTTGCAT GTTCAATTTG TCATAAAATG GTGCCCAGGT ATGACTTAAT CCGGCACCTT 
GATGAGTCTT GTGCTAACAA TGGTGAAATC GTTCAAAATG AGCCTGCTCA GGCTGGTTTA 
ATTAACTCAA CTGTGCCTAC ATCAGATTTA CCCAGTACTC CTTTAGAAGA TATGACACCT 
CAGAAGTTAT CACCACCAAA GAGACGTTTA ATCTCTGCCC AGTGTGGTTC AAAACTGGGC 
GTGCGACAGC AGACCAGTCC CTACTTTAAA AAAGCCTTGG TGTGCAAAAA TCAAAATAAG 
CTTCCAAATC AGAGTGTGGA AATCAGGTCT TTGGGAAGTC TGTCATCAAA ACTGTCCAGA 
AGGTACGTAA AAGCTAAAAA ATCACTCTCT AAGAACGAGG GGCTAGCCAG TCATTGCCCA 
CCGACTTCTC CGTCCCCACC TGGCCCCAGC CTGGTTGATA ACTGTCCAGA GATGGACAAC 
AAAGATGAGA TTTTAAACAG TTCCCAGAAG GAAAACATTT ACTCGTGTGC ACCTCTAGAG 
GAAGAGACCG CTTCAGAACA GAAGGTAAAG AGCAGTAAAA GGATGGGAGA TGGAAGTCAG 
AAAGCTTCCG GTGGGGAGCC GGCCCTCACG CCTGCATCCC CAGAGCAGGC CCCCACATTA 
CTGTCCTCAG ACTTAACTCT TGTCAATAAC ACGGATTCCT CTTCGGGAGA TGCTCTCGAA 
CAAGAAGGTG CTGGAAGGGT AGGTGTAGGG GTTGATGAAC AGCTTGCGGC ATGCAGCCAT 
GAAGAAGTAC AAATGACTGT TGATGCTGAG GTGGGAACGC TGGTGTCAGG GGGGGCGGAA 
TCAAACAGTC CTGCTGACAA CGACGACGAT GACGCATCTA CATGGAGTAA CAACCCAGAG 
CTTAGGGAAG CTGGCAGTGC CTTAAAGAGA CAAAGGGCTT GCAGTCCTCT GGAGCAGGGC 
GCCAGTTGTG TTCCCAGTGT GACAGCTCAA CCCCAACCGA GTCACCCGTA CTACCTGAGG 
AGCTTCCTGG TGGTTCTGCA GGCCATCCTT GAGAACGAAG AGGACATGAA GCTCTTCGAT 
GACCAGGAGA AGGGCGTTAT AGCTAAGTTT TACCAGCTGT CAGCCAGTGG TCAGAAGTTG 
TATGTGAGGC TCTTCCAACG TAAATTAACC TGGATTAAAG TGAGTAAACT GGAGTATGAA 
GAGATTGCCT CGGACTTAAC CCCTGTGGTT GAAGAATTGA AGAACTTAGG CTTTCTACAG 
ACAGAATCTG AGTTGCAAGA ACTCTCTGAT GTACTTGAAC TCCTTTCTGC TCCTGAGCTG 
AAAGCCCTGG CCAAAACCTT CCACTTGGTG AGTCCCGGTG GGCAGAAGCA GCAGCTGGTA 
GACGCCTTCC TCAAACTGGC CAGACAGCGC TCAGTCTACA CTTGGGGCAA GACTCAGCCT 
GGAATCAGAG CGGTGATTTT AAAGAGAGCT AAAGACTTGG CTGGCCCGTC CCTTCGAGTC 
TGTAAAGGCC CTAGGGCTGT GTTTTGCCGC CTCCTGCTTC TGTTCTCGTT GACTGATACC 
ATGGAAGACG AAGAAGCTGC GTGTGGGGGT CAAGGTCAGC TGTCTACTGT GCTATTGGTC 
AATCTGGGCC GAATGGAGTT TCCTCAGTAC AGCATCAGCC GGAAGACCCA GATCTTCAGG 
GACAGAGAGG ATCTTATCAG ATACGCAGCC GCCGCGCACA TGCTGAGTGA CATCTCAGCT 
GCCATGGCCA GTGGGAACTG GGAAGAAGCT AAGGAGCTTT CTCAGATTGC AAAGAGAGAC 
TGGGACCAAC TGAAAAGCCA CCCTTCCCTG AGATACCACG AGGCCTTGCC ACTCTTTCTG 
CGCTGTTTTA CTGTTGGGTG GATCTACACA AGGATTTCCT CTCGGGCTGT TGAAGTACTA 
GAGAGACTTC ACATGTACGA GGAAGCTGTC AAGGAACTTG AAAACCTCCT CGCTCAGAAA 
GTCTATTGTC CTGACAGCAG AGGCCGCTGG TGGGACCGCC TGGCTCTTAA CCTGCACCAG 
CACCTGAAGC GTCTGGAAGA GGCAATTTGG TGCATCAAGG AAGGCCTGGC AGATCCACAA 
GTGAGGACAG GACACCGACT TTCTCTTTAT CAGCGAGCTG TGCGCCTTCG AGAGTCTCCG 
AGCTGTAAAA AGTACAGGCA CCTATTCAGC CAGCTGCCAG AAGTCACTGT GGGAGACGTT 
AAGCATGTGA CCATCACAGG CAGGCTGTGC CCACAGCATG GGATGGGCAA GTCTGTGTTT 
GTCATTGAGG GTGGAGACCC CACCAACCCC ACCACAATCC TGTGTTCTGT GGAGGAACTG 
GCACTGGACT ATTACAGGCG GAGTGGCTTT GACCAAGGGA TTCACGGAGA AGGGTCCACC 
TTCAGCACCC TGTGTGGCCT CCTGCTGTGG GATATCATCT TCATGGATGG AATACCAGAT 
GTCTTCAGAA ATGCCTACCA GGCCTCCCCC CTGGATTTGC TCACAGACAG CTTCTTCTCA 
AGCAGGGAGC AGGCCCTGGA AGCCAGGCTG CAGCTGATCC ACAGCGCCCC TGCTGAGAGC 
CTGCGGGCCT GGGTGACTGA AGCATGGCAG GCCCAGCAAG GCAGGGCGGC TTCTCTGGTC 
AGCTGGGATC GCTTCACTTC CCTTCAGCAA GCTCAGGACC TTGTCTCCTG CCTCGGGGGT 
CCTGTCCTCA GCGGTGTGTG CAGGCGCCTG GCTGCTGACT TTCGGCACTG CCGAGGAGGC 
CTCCCTGATT TGGTGGTGTG GAATTCTCAG AGCCACCATT GCAAGCTGGT GGAAGTTAAA 
GGCCCCAGTG ATCGCCTGTC ATGTAAGCAG ATGATCTGGC TGGATGAACT ACAAAAGCTG 
GGGGCAGACG TAGAAGTATG CCATGTGGTT GCAGTTGGTG CTAAGAGCAA AGGTCTTGGC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Fan1 ( XM_006229339.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006229401.1 Rattus norvegicus FANCD2/FANCI-associated nuclease 1 (Fan1), transcript variant X1, mRNA.

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CloneID	ORa07283
Clone ID Related Accession (Same CDS sequence)	XM_006229339.3 , NM_001191633.1
Accession Version	XM_006229339.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3063bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	fanconi-associated nuclease 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006229339.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATGTCAC AAAAGAGCTC ACCTGCTCAA AAAAGACCCC GTAAAAGCTT ATCTACCGGC 
AAAACTACGA AAAGCCAATC TCATTCCATT ACTTCGTATT TTAACAGTGT ACCACCTGCT 
AAACTTGCAT GTTCAATTTG TCATAAAATG GTGCCCAGGT ATGACTTAAT CCGGCACCTT 
GATGAGTCTT GTGCTAACAA TGGTGAAATC GTTCAAAATG AGCCTGCTCA GGCTGGTTTA 
ATTAACTCAA CTGTGCCTAC ATCAGATTTA CCCAGTACTC CTTTAGAAGA TATGACACCT 
CAGAAGTTAT CACCACCAAA GAGACGTTTA ATCTCTGCCC AGTGTGGTTC AAAACTGGGC 
GTGCGACAGC AGACCAGTCC CTACTTTAAA AAAGCCTTGG TGTGCAAAAA TCAAAATAAG 
CTTCCAAATC AGAGTGTGGA AATCAGGTCT TTGGGAAGTC TGTCATCAAA ACTGTCCAGA 
AGGTACGTAA AAGCTAAAAA ATCACTCTCT AAGAACGAGG GGCTAGCCAG TCATTGCCCA 
CCGACTTCTC CGTCCCCACC TGGCCCCAGC CTGGTTGATA ACTGTCCAGA GATGGACAAC 
AAAGATGAGA TTTTAAACAG TTCCCAGAAG GAAAACATTT ACTCGTGTGC ACCTCTAGAG 
GAAGAGACCG CTTCAGAACA GAAGGTAAAG AGCAGTAAAA GGATGGGAGA TGGAAGTCAG 
AAAGCTTCCG GTGGGGAGCC GGCCCTCACG CCTGCATCCC CAGAGCAGGC CCCCACATTA 
CTGTCCTCAG ACTTAACTCT TGTCAATAAC ACGGATTCCT CTTCGGGAGA TGCTCTCGAA 
CAAGAAGGTG CTGGAAGGGT AGGTGTAGGG GTTGATGAAC AGCTTGCGGC ATGCAGCCAT 
GAAGAAGTAC AAATGACTGT TGATGCTGAG GTGGGAACGC TGGTGTCAGG GGGGGCGGAA 
TCAAACAGTC CTGCTGACAA CGACGACGAT GACGCATCTA CATGGAGTAA CAACCCAGAG 
CTTAGGGAAG CTGGCAGTGC CTTAAAGAGA CAAAGGGCTT GCAGTCCTCT GGAGCAGGGC 
GCCAGTTGTG TTCCCAGTGT GACAGCTCAA CCCCAACCGA GTCACCCGTA CTACCTGAGG 
AGCTTCCTGG TGGTTCTGCA GGCCATCCTT GAGAACGAAG AGGACATGAA GCTCTTCGAT 
GACCAGGAGA AGGGCGTTAT AGCTAAGTTT TACCAGCTGT CAGCCAGTGG TCAGAAGTTG 
TATGTGAGGC TCTTCCAACG TAAATTAACC TGGATTAAAG TGAGTAAACT GGAGTATGAA 
GAGATTGCCT CGGACTTAAC CCCTGTGGTT GAAGAATTGA AGAACTTAGG CTTTCTACAG 
ACAGAATCTG AGTTGCAAGA ACTCTCTGAT GTACTTGAAC TCCTTTCTGC TCCTGAGCTG 
AAAGCCCTGG CCAAAACCTT CCACTTGGTG AGTCCCGGTG GGCAGAAGCA GCAGCTGGTA 
GACGCCTTCC TCAAACTGGC CAGACAGCGC TCAGTCTACA CTTGGGGCAA GACTCAGCCT 
GGAATCAGAG CGGTGATTTT AAAGAGAGCT AAAGACTTGG CTGGCCCGTC CCTTCGAGTC 
TGTAAAGGCC CTAGGGCTGT GTTTTGCCGC CTCCTGCTTC TGTTCTCGTT GACTGATACC 
ATGGAAGACG AAGAAGCTGC GTGTGGGGGT CAAGGTCAGC TGTCTACTGT GCTATTGGTC 
AATCTGGGCC GAATGGAGTT TCCTCAGTAC AGCATCAGCC GGAAGACCCA GATCTTCAGG 
GACAGAGAGG ATCTTATCAG ATACGCAGCC GCCGCGCACA TGCTGAGTGA CATCTCAGCT 
GCCATGGCCA GTGGGAACTG GGAAGAAGCT AAGGAGCTTT CTCAGATTGC AAAGAGAGAC 
TGGGACCAAC TGAAAAGCCA CCCTTCCCTG AGATACCACG AGGCCTTGCC ACTCTTTCTG 
CGCTGTTTTA CTGTTGGGTG GATCTACACA AGGATTTCCT CTCGGGCTGT TGAAGTACTA 
GAGAGACTTC ACATGTACGA GGAAGCTGTC AAGGAACTTG AAAACCTCCT CGCTCAGAAA 
GTCTATTGTC CTGACAGCAG AGGCCGCTGG TGGGACCGCC TGGCTCTTAA CCTGCACCAG 
CACCTGAAGC GTCTGGAAGA GGCAATTTGG TGCATCAAGG AAGGCCTGGC AGATCCACAA 
GTGAGGACAG GACACCGACT TTCTCTTTAT CAGCGAGCTG TGCGCCTTCG AGAGTCTCCG 
AGCTGTAAAA AGTACAGGCA CCTATTCAGC CAGCTGCCAG AAGTCACTGT GGGAGACGTT 
AAGCATGTGA CCATCACAGG CAGGCTGTGC CCACAGCATG GGATGGGCAA GTCTGTGTTT 
GTCATTGAGG GTGGAGACCC CACCAACCCC ACCACAATCC TGTGTTCTGT GGAGGAACTG 
GCACTGGACT ATTACAGGCG GAGTGGCTTT GACCAAGGGA TTCACGGAGA AGGGTCCACC 
TTCAGCACCC TGTGTGGCCT CCTGCTGTGG GATATCATCT TCATGGATGG AATACCAGAT 
GTCTTCAGAA ATGCCTACCA GGCCTCCCCC CTGGATTTGC TCACAGACAG CTTCTTCTCA 
AGCAGGGAGC AGGCCCTGGA AGCCAGGCTG CAGCTGATCC ACAGCGCCCC TGCTGAGAGC 
CTGCGGGCCT GGGTGACTGA AGCATGGCAG GCCCAGCAAG GCAGGGCGGC TTCTCTGGTC 
AGCTGGGATC GCTTCACTTC CCTTCAGCAA GCTCAGGACC TTGTCTCCTG CCTCGGGGGT 
CCTGTCCTCA GCGGTGTGTG CAGGCGCCTG GCTGCTGACT TTCGGCACTG CCGAGGAGGC 
CTCCCTGATT TGGTGGTGTG GAATTCTCAG AGCCACCATT GCAAGCTGGT GGAAGTTAAA 
GGCCCCAGTG ATCGCCTGTC ATGTAAGCAG ATGATCTGGC TGGATGAACT ACAAAAGCTG 
GGGGCAGACG TAGAAGTATG CCATGTGGTT GCAGTTGGTG CTAAGAGCAA AGGTCTTGGC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006229401.1
CDS	432..3494
Translation	MMSQKSSPAQKRPRKSLSTGKTTKSQSHSITSYFNSVPPAKLACSICHKMVPRYDLIRHLDESCANNGEIVQNEPAQAGLINSTVPTSDLPSTPLEDMTPQKLSPPKRRLISAQCGSKLGVRQQTSPYFKKALVCKNQNKLPNQSVEIRSLGSLSSKLSRRYVKAKKSLSKNEGLASHCPPTSPSPPGPSLVDNCPEMDNKDEILNSSQKENIYSCAPLEEETASEQKVKSSKRMGDGSQKASGGEPALTPASPEQAPTLLSSDLTLVNNTDSSSGDALEQEGAGRVGVGVDEQLAACSHEEVQMTVDAEVGTLVSGGAESNSPADNDDDDASTWSNNPELREAGSALKRQRACSPLEQGASCVPSVTAQPQPSHPYYLRSFLVVLQAILENEEDMKLFDDQEKGVIAKFYQLSASGQKLYVRLFQRKLTWIKVSKLEYEEIASDLTPVVEELKNLGFLQTESELQELSDVLELLSAPELKALAKTFHLVSPGGQKQQLVDAFLKLARQRSVYTWGKTQPGIRAVILKRAKDLAGPSLRVCKGPRAVFCRLLLLFSLTDTMEDEEAACGGQGQLSTVLLVNLGRMEFPQYSISRKTQIFRDREDLIRYAAAAHMLSDISAAMASGNWEEAKELSQIAKRDWDQLKSHPSLRYHEALPLFLRCFTVGWIYTRISSRAVEVLERLHMYEEAVKELENLLAQKVYCPDSRGRWWDRLALNLHQHLKRLEEAIWCIKEGLADPQVRTGHRLSLYQRAVRLRESPSCKKYRHLFSQLPEVTVGDVKHVTITGRLCPQHGMGKSVFVIEGGDPTNPTTILCSVEELALDYYRRSGFDQGIHGEGSTFSTLCGLLLWDIIFMDGIPDVFRNAYQASPLDLLTDSFFSSREQALEARLQLIHSAPAESLRAWVTEAWQAQQGRAASLVSWDRFTSLQQAQDLVSCLGGPVLSGVCRRLAADFRHCRGGLPDLVVWNSQSHHCKLVEVKGPSDRLSCKQMIWLDELQKLGADVEVCHVVAVGAKSKGLG

Target ORF information:

RefSeq Version	XM_006229339.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus FANCD2/FANCI-associated nuclease 1 (Fan1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006229339.3

ORF Insert Sequence:

ATGATGTCAC AAAAGAGCTC ACCTGCTCAA AAAAGACCCC GTAAAAGCTT ATCTACCGGC 
AAAACTACGA AAAGCCAATC TCATTCCATT ACTTCGTATT TTAACAGTGT ACCACCTGCT 
AAACTTGCAT GTTCAATTTG TCATAAAATG GTGCCCAGGT ATGACTTAAT CCGGCACCTT 
GATGAGTCTT GTGCTAACAA TGGTGAAATC GTTCAAAATG AGCCTGCTCA GGCTGGTTTA 
ATTAACTCAA CTGTGCCTAC ATCAGATTTA CCCAGTACTC CTTTAGAAGA TATGACACCT 
CAGAAGTTAT CACCACCAAA GAGACGTTTA ATCTCTGCCC AGTGTGGTTC AAAACTGGGC 
GTGCGACAGC AGACCAGTCC CTACTTTAAA AAAGCCTTGG TGTGCAAAAA TCAAAATAAG 
CTTCCAAATC AGAGTGTGGA AATCAGGTCT TTGGGAAGTC TGTCATCAAA ACTGTCCAGA 
AGGTACGTAA AAGCTAAAAA ATCACTCTCT AAGAACGAGG GGCTAGCCAG TCATTGCCCA 
CCGACTTCTC CGTCCCCACC TGGCCCCAGC CTGGTTGATA ACTGTCCAGA GATGGACAAC 
AAAGATGAGA TTTTAAACAG TTCCCAGAAG GAAAACATTT ACTCGTGTGC ACCTCTAGAG 
GAAGAGACCG CTTCAGAACA GAAGGTAAAG AGCAGTAAAA GGATGGGAGA TGGAAGTCAG 
AAAGCTTCCG GTGGGGAGCC GGCCCTCACG CCTGCATCCC CAGAGCAGGC CCCCACATTA 
CTGTCCTCAG ACTTAACTCT TGTCAATAAC ACGGATTCCT CTTCGGGAGA TGCTCTCGAA 
CAAGAAGGTG CTGGAAGGGT AGGTGTAGGG GTTGATGAAC AGCTTGCGGC ATGCAGCCAT 
GAAGAAGTAC AAATGACTGT TGATGCTGAG GTGGGAACGC TGGTGTCAGG GGGGGCGGAA 
TCAAACAGTC CTGCTGACAA CGACGACGAT GACGCATCTA CATGGAGTAA CAACCCAGAG 
CTTAGGGAAG CTGGCAGTGC CTTAAAGAGA CAAAGGGCTT GCAGTCCTCT GGAGCAGGGC 
GCCAGTTGTG TTCCCAGTGT GACAGCTCAA CCCCAACCGA GTCACCCGTA CTACCTGAGG 
AGCTTCCTGG TGGTTCTGCA GGCCATCCTT GAGAACGAAG AGGACATGAA GCTCTTCGAT 
GACCAGGAGA AGGGCGTTAT AGCTAAGTTT TACCAGCTGT CAGCCAGTGG TCAGAAGTTG 
TATGTGAGGC TCTTCCAACG TAAATTAACC TGGATTAAAG TGAGTAAACT GGAGTATGAA 
GAGATTGCCT CGGACTTAAC CCCTGTGGTT GAAGAATTGA AGAACTTAGG CTTTCTACAG 
ACAGAATCTG AGTTGCAAGA ACTCTCTGAT GTACTTGAAC TCCTTTCTGC TCCTGAGCTG 
AAAGCCCTGG CCAAAACCTT CCACTTGGTG AGTCCCGGTG GGCAGAAGCA GCAGCTGGTA 
GACGCCTTCC TCAAACTGGC CAGACAGCGC TCAGTCTACA CTTGGGGCAA GACTCAGCCT 
GGAATCAGAG CGGTGATTTT AAAGAGAGCT AAAGACTTGG CTGGCCCGTC CCTTCGAGTC 
TGTAAAGGCC CTAGGGCTGT GTTTTGCCGC CTCCTGCTTC TGTTCTCGTT GACTGATACC 
ATGGAAGACG AAGAAGCTGC GTGTGGGGGT CAAGGTCAGC TGTCTACTGT GCTATTGGTC 
AATCTGGGCC GAATGGAGTT TCCTCAGTAC AGCATCAGCC GGAAGACCCA GATCTTCAGG 
GACAGAGAGG ATCTTATCAG ATACGCAGCC GCCGCGCACA TGCTGAGTGA CATCTCAGCT 
GCCATGGCCA GTGGGAACTG GGAAGAAGCT AAGGAGCTTT CTCAGATTGC AAAGAGAGAC 
TGGGACCAAC TGAAAAGCCA CCCTTCCCTG AGATACCACG AGGCCTTGCC ACTCTTTCTG 
CGCTGTTTTA CTGTTGGGTG GATCTACACA AGGATTTCCT CTCGGGCTGT TGAAGTACTA 
GAGAGACTTC ACATGTACGA GGAAGCTGTC AAGGAACTTG AAAACCTCCT CGCTCAGAAA 
GTCTATTGTC CTGACAGCAG AGGCCGCTGG TGGGACCGCC TGGCTCTTAA CCTGCACCAG 
CACCTGAAGC GTCTGGAAGA GGCAATTTGG TGCATCAAGG AAGGCCTGGC AGATCCACAA 
GTGAGGACAG GACACCGACT TTCTCTTTAT CAGCGAGCTG TGCGCCTTCG AGAGTCTCCG 
AGCTGTAAAA AGTACAGGCA CCTATTCAGC CAGCTGCCAG AAGTCACTGT GGGAGACGTT 
AAGCATGTGA CCATCACAGG CAGGCTGTGC CCACAGCATG GGATGGGCAA GTCTGTGTTT 
GTCATTGAGG GTGGAGACCC CACCAACCCC ACCACAATCC TGTGTTCTGT GGAGGAACTG 
GCACTGGACT ATTACAGGCG GAGTGGCTTT GACCAAGGGA TTCACGGAGA AGGGTCCACC 
TTCAGCACCC TGTGTGGCCT CCTGCTGTGG GATATCATCT TCATGGATGG AATACCAGAT 
GTCTTCAGAA ATGCCTACCA GGCCTCCCCC CTGGATTTGC TCACAGACAG CTTCTTCTCA 
AGCAGGGAGC AGGCCCTGGA AGCCAGGCTG CAGCTGATCC ACAGCGCCCC TGCTGAGAGC 
CTGCGGGCCT GGGTGACTGA AGCATGGCAG GCCCAGCAAG GCAGGGCGGC TTCTCTGGTC 
AGCTGGGATC GCTTCACTTC CCTTCAGCAA GCTCAGGACC TTGTCTCCTG CCTCGGGGGT 
CCTGTCCTCA GCGGTGTGTG CAGGCGCCTG GCTGCTGACT TTCGGCACTG CCGAGGAGGC 
CTCCCTGATT TGGTGGTGTG GAATTCTCAG AGCCACCATT GCAAGCTGGT GGAAGTTAAA 
GGCCCCAGTG ATCGCCTGTC ATGTAAGCAG ATGATCTGGC TGGATGAACT ACAAAAGCTG 
GGGGCAGACG TAGAAGTATG CCATGTGGTT GCAGTTGGTG CTAAGAGCAA AGGTCTTGGC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

DNA repair. Mechanism of DNA interstrand cross-link processing by repair nuclease FAN1.
Science (New York, N.Y.)346(6213)1127-30(2014 Nov)
Wang R,Persky NS,Yoo B,Ouerfelli O,Smogorzewska A,Elledge SJ,Pavletich NP

FAN1 activity on asymmetric repair intermediates is mediated by an atypical monomeric virus-type replication-repair nuclease domain.
Cell reports8(1)84-93(2014 Jul)
Pennell S,Déclais AC,Li J,Haire LF,Berg W,Saldanha JW,Taylor IA,Rouse J,Lilley DM,Smerdon SJ

A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair.
Molecular cell39(1)36-47(2010 Jul)
Smogorzewska A,Desetty R,Saito TT,Schlabach M,Lach FP,Sowa ME,Clark AB,Kunkel TA,Harper JW,Colaiácovo MP,Elledge SJ

Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agents.
Cell142(1)77-88(2010 Jul)
Kratz K,Schöpf B,Kaden S,Sendoel A,Eberhard R,Lademann C,Cannavó E,Sartori AA,Hengartner MO,Jiricny J

Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2.
Cell142(1)65-76(2010 Jul)
MacKay C,Déclais AC,Lundin C,Agostinho A,Deans AJ,MacArtney TJ,Hofmann K,Gartner A,West SC,Helleday T,Lilley DM,Rouse J

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Fan1 cDNA ORF clone, Rattus norvegicus(Norway rat)

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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