Cul4b cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cul4b
Entrez Gene ID	302502
Full Name	cullin 4B
Synonyms	RGD1564494
General protein information	Preferred Names cullin 4B Names cullin-4B
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: X Map Location: Xq35

mRNA and Protein(s)

mRNA	Protein	Name
XM_006257489.3	XP_006257551.1	cullin-4B isoform X1
NM_001106951.1	NP_001100421.1	cullin-4B

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	CUL4B	XP_864628.3
Mus musculus (house mouse)	Cul4b	NP_001103612.1
Danio rerio (zebrafish)	cul4b	NP_001116316.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007727	XP_308149.4
Homo sapiens (human)	CUL4B	NP_001073341.1
Macaca mulatta (Rhesus monkey)	CUL4B	XP_001086195.1
Gallus gallus (chicken)	CUL4B	XP_420335.2
Rattus norvegicus (Norway rat)	Cul4b	NP_001100421.1
Arabidopsis thaliana (thale cress)	CUL4	NP_568658.1
Xenopus tropicalis (tropical clawed frog)	cul4b	NP_001120891.1
Bos taurus (cattle)	CUL4B	XP_005227530.1
Drosophila melanogaster (fruit fly)	Cul-4	NP_001163084.1

Gene Ontology
Bibliography

Related articles in PubMed

CUL4B promotes the pathology of adjuvant-induced arthritis in rats through the canonical Wnt signaling.
Miao C, Chang J, Zhang G, Yu H, Zhou L, Zhou G, Zhao C
Journal of molecular medicine (Berlin, Germany)96(6)495-511(2018 06)

Selective degradation of splicing factor CAPERα by anticancer sulfonamides.
Uehara T, Minoshima Y, Sagane K, Sugi NH, Mitsuhashi KO, Yamamoto N, Kamiyama H, Takahashi K, Kotake Y, Uesugi M, Yokoi A, Inoue A, Yoshida T, Mabuchi M, Tanaka A, Owa T
Nature chemical biology13(6)675-680(2017 06)

Genome-wide RNAi Screening Identifies Protein Modules Required for 40S Subunit Synthesis in Human Cells.
Badertscher L, Wild T, Montellese C, Alexander LT, Bammert L, Sarazova M, Stebler M, Csucs G, Mayer TU, Zamboni N, Zemp I, Horvath P, Kutay U
Cell reports13(12)2879-91(2015 Dec)

FBXO44-Mediated Degradation of RGS2 Protein Uniquely Depends on a Cullin 4B/DDB1 Complex.
Sjögren B, Swaney S, Neubig RR
PloS one10(5)e0123581(2015)

Monoubiquitinated histone H2A destabilizes photolesion-containing nucleosomes with concomitant release of UV-damaged DNA-binding protein E3 ligase.
Lan L, Nakajima S, Kapetanaki MG, Hsieh CL, Fagerburg M, Thickman K, Rodriguez-Collazo P, Leuba SH, Levine AS, Rapić-Otrin V
The Journal of biological chemistry287(15)12036-49(2012 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Cul4b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cul4b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa02585	NM_001106951.1 Latest version!	Rattus norvegicus cullin 4B (Cul4b), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00
ORa40212	XM_006257489.3 Latest version!	Rattus norvegicus cullin 4B (Cul4b), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cul4b ( NM_001106951.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001100421.1 Rattus norvegicus cullin 4B (Cul4b), mRNA.

Price & Availability↑

CloneID	ORa02585
Clone ID Related Accession (Same CDS sequence)	NM_001106951.1
Accession Version	NM_001106951.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2916bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1571587200000
Organism	Rattus norvegicus(Norway rat)
Product	cullin-4B
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473991.1. On or before Oct 4, 2007 this sequence version replaced XM_001058651.1, XM_228689.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGTCACGTT CAACTAAGTC TAGAGAAAGA AGAGAGAATG ATGCCAACTC AGAAGATAAC 
AGTTCAGAAA CCTCCAATCA AGAGCGCCGA AGGTGTCTCC AAGGCCCGCC CCGTCCTCCC 
TATCCACCTC TTTTACCCCC GGTGTTCCCT CCCCCAACCC CCCCACCTCA AGTCCGGCGG 
ACCCGGGGGC TTCAGGATCT GGGAGCTATG AAAAGTGTCT GCCCAGGCAC TTCCGGTTTT 
TCTTCCCCCA ATCCCTCTGC TGCTTCTGCT GCTGCTCAGG AGGTCAGATC TGCCACTGAT 
GGTAATACCA GCACCACTCC GCCCACCTCT GCCAAGAAGA GAAAGTTAAA CAGCAGCAGC 
AGCAGTAGCA GCAGTAACAG TAGTAACGAG AGAGAAGACT TTGATTCCAC CTCTTCCTCC 
TCCACCCCTC CACAACCCAG AGATTCGGCG TCCCCTTCAA CCTCATCCTT CTGCCTCGGG 
GTTCCAGTGG CCACTTCCAG CCACGTACCT ATACAGAAGA AGCTGCGTTT TGAAGACACC 
CTGGAGTTTG TAGGGTTTGA TACGAAAATG GCTGAGGAAT CTTCCTCCTC ATCTTCCTCA 
TCTTCACCAA CTGCTGCAAC CTCACAGCAG CAACAGCAGC AACTTAAAAA TAAGAGTATA 
TTAATTTCTT CGGTGGCTTC AGTGCACCAT GCAAACGGCC TGGCTAAATC TTCTACCACG 
GTCTCTAGCT TTGCTAACAG CAAGCCTGGC TCAGCTAAGA AGTTAGTGAT CAAGAACTTT 
AAAGATAAGC CTAAATTACC AGAAAACTAT ACAGATGAGA CATGGCAAAA GCTAAAAGAA 
GCAGTGGAAG CCATTCAGAA TAGTACTTCA ATTAAGTACA ATTTAGAAGA ACTCTACCAG 
GCTGTAGAAA ATCTTTGTTC TTACAAGATT TCTGCCAATT TGTATAAGCA GCTGAGGCAG 
ATCTGTGAAG ATCACATCAA AGCACAGATT CATCAGTTCA GAGAGGATTC ATTGGATAGT 
GTTCTTTTTC TAAAAAAGAT TGATAGATGC TGGCAAAATC ATTGTAGGCA AATGATAATG 
ATCAGGAGCA TTTTTTTGTT TCTGGATAGA ACTTATGTTC TTCAGAATTC AATGCTGCCC 
TCTATTTGGG ACATGGGATT AGAGTTATTT AGGGCTCATA TTATAAGTGA TCAAAAAGTC 
CAGACAAAAA CAATCGATGG CATCCTTCTC TTGATTGAGA GAGAGCGGAA TGGTGAAGCA 
ATTGATAGAA GTTTACTTCG AAGCCTTTTA AATATGCTGT CTGACTTGCA AATTTACCAA 
GACTCTTTTG AACAACGATT TTTGCAAGAA ACTAATCGGC TTTATGCGGC CGAAGGTCAG 
AAGTTAATGC AAGAAAGAGA GGTTCCTGAG TATCTTCATC ATGTTAATAA ACGCCTAGAA 
GAAGAAGCAG ACAGACTTAT TACTTACTTA GATCAGACCA CCCAGAAGTC ACTGATTGCT 
TCTGTTGAAA AACAACTTCT AGGTGAACAC TTAACAGCAA TTCTTCAGAA AGGTTTAAAT 
AGCCTCCTTG ATGAAAACCG AATTCAAGAT CTGTCTCTCC TGTATCAGCT CTTCAGTAGA 
GTTCGGGGAG GAGTTCAGGT TCTCCTACAG CACTGGATTG AGTATATCAA GGCTTTTGGA 
AGTACCATTG TTATTAATCC TGAAAAAGAT AAAACTATGG TTCAAGAATT ATTGGACTTT 
AAAGATAAAG TTGACCATAT AATTGATACC TGCTTTCTGA AAAATGAAAA ATTTATCAAT 
GCCATGAAAG AAGCATTTGA AACCTTCATT AATAAAAGAC CAAATAAGCC AGCTGAACTG 
ATAGCTAAGT ATGTGGATTC AAAACTTCGT GCAGGCAACA AAGAAGCTAC AGATGAAGAG 
CTTGAGAAAA TGTTGGATAA AATAATGATT ATATTTAGAT TTATCTATGG CAAAGATGTT 
TTTGAGGCCT TCTATAAGAA AGACTTAGCC AAACGCCTAT TAGTTGGCAA GAGTGCATCA 
GTGGATGCTG AAAAATCAAT GCTGTCCAAA CTGAAACACG AATGTGGAGC CGCTTTTACC 
AGCAAGCTTG AAGGCATGTT TAAAGACATG GAGCTTTCTA AAGATATCAT GATCCAGTTC 
AAACAGTATA TGCAGAACCA GAATGTACCT GGCAATATTG AATTAACTGT TAATATCCTG 
ACAATGGGTT ATTGGCCAAC ATATGTGCCT ATGGAAGTCC ATTTGCCACC AGAGATGGTG 
AAGCTTCAGG AAATTTTCAA GACATTTTAC TTAGGCAAGC ACAGTGGCAG GAAACTTCAA 
TGGCAATCAA CCTTGGGACA CTGTGTGCTA AAAGCTGAAT TTAAAGAGGG CAAAAAAGAA 
CTTCAGGTCT CTCTTTTTCA AACCCTGGTG CTACTAATGT TTAATGAAGG AGAGGAGTTC 
AGTTTAGAGG AGATAAAGCA AGCCACTGGA ATAGAGGATG GAGAATTAAG AAGAACACTG 
CAGTCACTAG CCTGTGGCAA AGCTAGAGTT CTGGCTAAAA ATCCAAAGGG CAAAGATATT 
GAAGATGGTG ACAAGTTTAT TTGTAATGAT GATTTCAAAC ACAAACTATT CAGGATAAAG 
ATCAATCAAA TCCAGATGAA AGAAACGGTT GAAGAACAAG CAAGCACTAC AGAAAGAGTA 
TTTCAAGATA GACAGTACCA AATTGATGCT GCGATCGTCC GAATTATGAA GATGAGAAAA 
ACACTTAGCC ACAACCTTCT TGTTTCAGAA GTCTACAATC AGCTAAAATT TCCAGTAAAA 
CCTGCTGATC TTAAGAAGAG AATAGAATCC CTAATTGACC GGGACTACAT GGAAAGAGAT 
AAAGAAAACC CAAATCAGTA CAACTATATT GCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001100421.1
CDS	119..3034
Translation	MSRSTKSRERRENDANSEDNSSETSNQERRRCLQGPPRPPYPPLLPPVFPPPTPPPQVRRTRGLQDLGAMKSVCPGTSGFSSPNPSAASAAAQEVRSATDGNTSTTPPTSAKKRKLNSSSSSSSSNSSNEREDFDSTSSSSTPPQPRDSASPSTSSFCLGVPVATSSHVPIQKKLRFEDTLEFVGFDTKMAEESSSSSSSSSPTAATSQQQQQQLKNKSILISSVASVHHANGLAKSSTTVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEELYQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQTKTIDGILLLIERERNGEAIDRSLLRSLLNMLSDLQIYQDSFEQRFLQETNRLYAAEGQKLMQEREVPEYLHHVNKRLEEEADRLITYLDQTTQKSLIASVEKQLLGEHLTAILQKGLNSLLDENRIQDLSLLYQLFSRVRGGVQVLLQHWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDTCFLKNEKFINAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRRTLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDYMERDKENPNQYNYIA

Target ORF information:

RefSeq Version	NM_001106951.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cullin 4B (Cul4b), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001106951.1

ORF Insert Sequence:

ATGTCACGTT CAACTAAGTC TAGAGAAAGA AGAGAGAATG ATGCCAACTC AGAAGATAAC 
AGTTCAGAAA CCTCCAATCA AGAGCGCCGA AGGTGTCTCC AAGGCCCGCC CCGTCCTCCC 
TATCCACCTC TTTTACCCCC GGTGTTCCCT CCCCCAACCC CCCCACCTCA AGTCCGGCGG 
ACCCGGGGGC TTCAGGATCT GGGAGCTATG AAAAGTGTCT GCCCAGGCAC TTCCGGTTTT 
TCTTCCCCCA ATCCCTCTGC TGCTTCTGCT GCTGCTCAGG AGGTCAGATC TGCCACTGAT 
GGTAATACCA GCACCACTCC GCCCACCTCT GCCAAGAAGA GAAAGTTAAA CAGCAGCAGC 
AGCAGTAGCA GCAGTAACAG TAGTAACGAG AGAGAAGACT TTGATTCCAC CTCTTCCTCC 
TCCACCCCTC CACAACCCAG AGATTCGGCG TCCCCTTCAA CCTCATCCTT CTGCCTCGGG 
GTTCCAGTGG CCACTTCCAG CCACGTACCT ATACAGAAGA AGCTGCGTTT TGAAGACACC 
CTGGAGTTTG TAGGGTTTGA TACGAAAATG GCTGAGGAAT CTTCCTCCTC ATCTTCCTCA 
TCTTCACCAA CTGCTGCAAC CTCACAGCAG CAACAGCAGC AACTTAAAAA TAAGAGTATA 
TTAATTTCTT CGGTGGCTTC AGTGCACCAT GCAAACGGCC TGGCTAAATC TTCTACCACG 
GTCTCTAGCT TTGCTAACAG CAAGCCTGGC TCAGCTAAGA AGTTAGTGAT CAAGAACTTT 
AAAGATAAGC CTAAATTACC AGAAAACTAT ACAGATGAGA CATGGCAAAA GCTAAAAGAA 
GCAGTGGAAG CCATTCAGAA TAGTACTTCA ATTAAGTACA ATTTAGAAGA ACTCTACCAG 
GCTGTAGAAA ATCTTTGTTC TTACAAGATT TCTGCCAATT TGTATAAGCA GCTGAGGCAG 
ATCTGTGAAG ATCACATCAA AGCACAGATT CATCAGTTCA GAGAGGATTC ATTGGATAGT 
GTTCTTTTTC TAAAAAAGAT TGATAGATGC TGGCAAAATC ATTGTAGGCA AATGATAATG 
ATCAGGAGCA TTTTTTTGTT TCTGGATAGA ACTTATGTTC TTCAGAATTC AATGCTGCCC 
TCTATTTGGG ACATGGGATT AGAGTTATTT AGGGCTCATA TTATAAGTGA TCAAAAAGTC 
CAGACAAAAA CAATCGATGG CATCCTTCTC TTGATTGAGA GAGAGCGGAA TGGTGAAGCA 
ATTGATAGAA GTTTACTTCG AAGCCTTTTA AATATGCTGT CTGACTTGCA AATTTACCAA 
GACTCTTTTG AACAACGATT TTTGCAAGAA ACTAATCGGC TTTATGCGGC CGAAGGTCAG 
AAGTTAATGC AAGAAAGAGA GGTTCCTGAG TATCTTCATC ATGTTAATAA ACGCCTAGAA 
GAAGAAGCAG ACAGACTTAT TACTTACTTA GATCAGACCA CCCAGAAGTC ACTGATTGCT 
TCTGTTGAAA AACAACTTCT AGGTGAACAC TTAACAGCAA TTCTTCAGAA AGGTTTAAAT 
AGCCTCCTTG ATGAAAACCG AATTCAAGAT CTGTCTCTCC TGTATCAGCT CTTCAGTAGA 
GTTCGGGGAG GAGTTCAGGT TCTCCTACAG CACTGGATTG AGTATATCAA GGCTTTTGGA 
AGTACCATTG TTATTAATCC TGAAAAAGAT AAAACTATGG TTCAAGAATT ATTGGACTTT 
AAAGATAAAG TTGACCATAT AATTGATACC TGCTTTCTGA AAAATGAAAA ATTTATCAAT 
GCCATGAAAG AAGCATTTGA AACCTTCATT AATAAAAGAC CAAATAAGCC AGCTGAACTG 
ATAGCTAAGT ATGTGGATTC AAAACTTCGT GCAGGCAACA AAGAAGCTAC AGATGAAGAG 
CTTGAGAAAA TGTTGGATAA AATAATGATT ATATTTAGAT TTATCTATGG CAAAGATGTT 
TTTGAGGCCT TCTATAAGAA AGACTTAGCC AAACGCCTAT TAGTTGGCAA GAGTGCATCA 
GTGGATGCTG AAAAATCAAT GCTGTCCAAA CTGAAACACG AATGTGGAGC CGCTTTTACC 
AGCAAGCTTG AAGGCATGTT TAAAGACATG GAGCTTTCTA AAGATATCAT GATCCAGTTC 
AAACAGTATA TGCAGAACCA GAATGTACCT GGCAATATTG AATTAACTGT TAATATCCTG 
ACAATGGGTT ATTGGCCAAC ATATGTGCCT ATGGAAGTCC ATTTGCCACC AGAGATGGTG 
AAGCTTCAGG AAATTTTCAA GACATTTTAC TTAGGCAAGC ACAGTGGCAG GAAACTTCAA 
TGGCAATCAA CCTTGGGACA CTGTGTGCTA AAAGCTGAAT TTAAAGAGGG CAAAAAAGAA 
CTTCAGGTCT CTCTTTTTCA AACCCTGGTG CTACTAATGT TTAATGAAGG AGAGGAGTTC 
AGTTTAGAGG AGATAAAGCA AGCCACTGGA ATAGAGGATG GAGAATTAAG AAGAACACTG 
CAGTCACTAG CCTGTGGCAA AGCTAGAGTT CTGGCTAAAA ATCCAAAGGG CAAAGATATT 
GAAGATGGTG ACAAGTTTAT TTGTAATGAT GATTTCAAAC ACAAACTATT CAGGATAAAG 
ATCAATCAAA TCCAGATGAA AGAAACGGTT GAAGAACAAG CAAGCACTAC AGAAAGAGTA 
TTTCAAGATA GACAGTACCA AATTGATGCT GCGATCGTCC GAATTATGAA GATGAGAAAA 
ACACTTAGCC ACAACCTTCT TGTTTCAGAA GTCTACAATC AGCTAAAATT TCCAGTAAAA 
CCTGCTGATC TTAAGAAGAG AATAGAATCC CTAATTGACC GGGACTACAT GGAAAGAGAT 
AAAGAAAACC CAAATCAGTA CAACTATATT GCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cul4b ( XM_006257489.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006257551.1 Rattus norvegicus cullin 4B (Cul4b), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa40212
Clone ID Related Accession (Same CDS sequence)	XM_006257489.3
Accession Version	XM_006257489.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2730bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	cullin-4B isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005120.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006257489.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTGGCGCG AAGCTCACCG CGGGACCCTT AAGGAACGGG TGGCTGATGG TTTTTCTTCC 
CCCAATCCCT CTGCTGCTTC TGCTGCTGCT CAGGAGGTCA GATCTGCCAC TGATGGTAAT 
ACCAGCACCA CTCCGCCCAC CTCTGCCAAG AAGAGAAAGT TAAACAGCAG CAGCAGCAGT 
AGCAGCAGTA ACAGTAGTAA CGAGAGAGAA GACTTTGATT CCACCTCTTC CTCCTCCACC 
CCTCCACAAC CCAGAGATTC GGCGTCCCCT TCAACCTCAT CCTTCTGCCT CGGGGTTCCA 
GTGGCCACTT CCAGCCACGT ACCTATACAG AAGAAGCTGC GTTTTGAAGA CACCCTGGAG 
TTTGTAGGGT TTGATACGAA AATGGCTGAG GAATCTTCCT CCTCATCTTC CTCATCTTCA 
CCAACTGCTG CAACCTCACA GCAGCAACAG CAGCAACTTA AAAATAAGAG TATATTAATT 
TCTTCGGTGG CTTCAGTGCA CCATGCAAAC GGCCTGGCTA AATCTTCTAC CACGGTCTCT 
AGCTTTGCTA ACAGCAAGCC TGGCTCAGCT AAGAAGTTAG TGATCAAGAA CTTTAAAGAT 
AAGCCTAAAT TACCAGAAAA CTATACAGAT GAGACATGGC AAAAGCTAAA AGAAGCAGTG 
GAAGCCATTC AGAATAGTAC TTCAATTAAG TACAATTTAG AAGAACTCTA CCAGGCTGTA 
GAAAATCTTT GTTCTTACAA GATTTCTGCC AATTTGTATA AGCAGCTGAG GCAGATCTGT 
GAAGATCACA TCAAAGCACA GATTCATCAG TTCAGAGAGG ATTCATTGGA TAGTGTTCTT 
TTTCTAAAAA AGATTGATAG ATGCTGGCAA AATCATTGTA GGCAAATGAT AATGATCAGG 
AGCATTTTTT TGTTTCTGGA TAGAACTTAT GTTCTTCAGA ATTCAATGCT GCCCTCTATT 
TGGGACATGG GATTAGAGTT ATTTAGGGCT CATATTATAA GTGATCAAAA AGTCCAGACA 
AAAACAATCG ATGGCATCCT TCTCTTGATT GAGAGAGAGC GGAATGGTGA AGCAATTGAT 
AGAAGTTTAC TTCGAAGCCT TTTAAATATG CTGTCTGACT TGCAAATTTA CCAAGACTCT 
TTTGAACAAC GATTTTTGCA AGAAACTAAT CGGCTTTATG CGGCCGAAGG TCAGAAGTTA 
ATGCAAGAAA GAGAGGTTCC TGAGTATCTT CATCATGTTA ATAAACGCCT AGAAGAAGAA 
GCAGACAGAC TTATTACTTA CTTAGATCAG ACCACCCAGA AGTCACTGAT TGCTTCTGTT 
GAAAAACAAC TTCTAGGTGA ACACTTAACA GCAATTCTTC AGAAAGGTTT AAATAGCCTC 
CTTGATGAAA ACCGAATTCA AGATCTGTCT CTCCTGTATC AGCTCTTCAG TAGAGTTCGG 
GGAGGAGTTC AGGTTCTCCT ACAGCACTGG ATTGAGTATA TCAAGGCTTT TGGAAGTACC 
ATTGTTATTA ATCCTGAAAA AGATAAAACT ATGGTTCAAG AATTATTGGA CTTTAAAGAT 
AAAGTTGACC ATATAATTGA TACCTGCTTT CTGAAAAATG AAAAATTTAT CAATGCCATG 
AAAGAAGCAT TTGAAACCTT CATTAATAAA AGACCAAATA AGCCAGCTGA ACTGATAGCT 
AAGTATGTGG ATTCAAAACT TCGTGCAGGC AACAAAGAAG CTACAGATGA AGAGCTTGAG 
AAAATGTTGG ATAAAATAAT GATTATATTT AGATTTATCT ATGGCAAAGA TGTTTTTGAG 
GCCTTCTATA AGAAAGACTT AGCCAAACGC CTATTAGTTG GCAAGAGTGC ATCAGTGGAT 
GCTGAAAAAT CAATGCTGTC CAAACTGAAA CACGAATGTG GAGCCGCTTT TACCAGCAAG 
CTTGAAGGCA TGTTTAAAGA CATGGAGCTT TCTAAAGATA TCATGATCCA GTTCAAACAG 
TATATGCAGA ACCAGAATGT ACCTGGCAAT ATTGAATTAA CTGTTAATAT CCTGACAATG 
GGTTATTGGC CAACATATGT GCCTATGGAA GTCCATTTGC CACCAGAGAT GGTGAAGCTT 
CAGGAAATTT TCAAGACATT TTACTTAGGC AAGCACAGTG GCAGGAAACT TCAATGGCAA 
TCAACCTTGG GACACTGTGT GCTAAAAGCT GAATTTAAAG AGGGCAAAAA AGAACTTCAG 
GTCTCTCTTT TTCAAACCCT GGTGCTACTA ATGTTTAATG AAGGAGAGGA GTTCAGTTTA 
GAGGAGATAA AGCAAGCCAC TGGAATAGAG GATGGAGAAT TAAGAAGAAC ACTGCAGTCA 
CTAGCCTGTG GCAAAGCTAG AGTTCTGGCT AAAAATCCAA AGGGCAAAGA TATTGAAGAT 
GGTGACAAGT TTATTTGTAA TGATGATTTC AAACACAAAC TATTCAGGAT AAAGATCAAT 
CAAATCCAGA TGAAAGAAAC GGTTGAAGAA CAAGCAAGCA CTACAGAAAG AGTATTTCAA 
GATAGACAGT ACCAAATTGA TGCTGCGATC GTCCGAATTA TGAAGATGAG AAAAACACTT 
AGCCACAACC TTCTTGTTTC AGAAGTCTAC AATCAGCTAA AATTTCCAGT AAAACCTGCT 
GATCTTAAGA AGAGAATAGA ATCCCTAATT GACCGGGACT ACATGGAAAG AGATAAAGAA 
AACCCAAATC AGTACAACTA TATTGCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006257551.1
CDS	34..2763
Translation	MWREAHRGTLKERVADGFSSPNPSAASAAAQEVRSATDGNTSTTPPTSAKKRKLNSSSSSSSSNSSNEREDFDSTSSSSTPPQPRDSASPSTSSFCLGVPVATSSHVPIQKKLRFEDTLEFVGFDTKMAEESSSSSSSSSPTAATSQQQQQQLKNKSILISSVASVHHANGLAKSSTTVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEELYQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQTKTIDGILLLIERERNGEAIDRSLLRSLLNMLSDLQIYQDSFEQRFLQETNRLYAAEGQKLMQEREVPEYLHHVNKRLEEEADRLITYLDQTTQKSLIASVEKQLLGEHLTAILQKGLNSLLDENRIQDLSLLYQLFSRVRGGVQVLLQHWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDTCFLKNEKFINAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRRTLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDYMERDKENPNQYNYIA

Target ORF information:

RefSeq Version	XM_006257489.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cullin 4B (Cul4b), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006257489.3

ORF Insert Sequence:

ATGTGGCGCG AAGCTCACCG CGGGACCCTT AAGGAACGGG TGGCTGATGG TTTTTCTTCC 
CCCAATCCCT CTGCTGCTTC TGCTGCTGCT CAGGAGGTCA GATCTGCCAC TGATGGTAAT 
ACCAGCACCA CTCCGCCCAC CTCTGCCAAG AAGAGAAAGT TAAACAGCAG CAGCAGCAGT 
AGCAGCAGTA ACAGTAGTAA CGAGAGAGAA GACTTTGATT CCACCTCTTC CTCCTCCACC 
CCTCCACAAC CCAGAGATTC GGCGTCCCCT TCAACCTCAT CCTTCTGCCT CGGGGTTCCA 
GTGGCCACTT CCAGCCACGT ACCTATACAG AAGAAGCTGC GTTTTGAAGA CACCCTGGAG 
TTTGTAGGGT TTGATACGAA AATGGCTGAG GAATCTTCCT CCTCATCTTC CTCATCTTCA 
CCAACTGCTG CAACCTCACA GCAGCAACAG CAGCAACTTA AAAATAAGAG TATATTAATT 
TCTTCGGTGG CTTCAGTGCA CCATGCAAAC GGCCTGGCTA AATCTTCTAC CACGGTCTCT 
AGCTTTGCTA ACAGCAAGCC TGGCTCAGCT AAGAAGTTAG TGATCAAGAA CTTTAAAGAT 
AAGCCTAAAT TACCAGAAAA CTATACAGAT GAGACATGGC AAAAGCTAAA AGAAGCAGTG 
GAAGCCATTC AGAATAGTAC TTCAATTAAG TACAATTTAG AAGAACTCTA CCAGGCTGTA 
GAAAATCTTT GTTCTTACAA GATTTCTGCC AATTTGTATA AGCAGCTGAG GCAGATCTGT 
GAAGATCACA TCAAAGCACA GATTCATCAG TTCAGAGAGG ATTCATTGGA TAGTGTTCTT 
TTTCTAAAAA AGATTGATAG ATGCTGGCAA AATCATTGTA GGCAAATGAT AATGATCAGG 
AGCATTTTTT TGTTTCTGGA TAGAACTTAT GTTCTTCAGA ATTCAATGCT GCCCTCTATT 
TGGGACATGG GATTAGAGTT ATTTAGGGCT CATATTATAA GTGATCAAAA AGTCCAGACA 
AAAACAATCG ATGGCATCCT TCTCTTGATT GAGAGAGAGC GGAATGGTGA AGCAATTGAT 
AGAAGTTTAC TTCGAAGCCT TTTAAATATG CTGTCTGACT TGCAAATTTA CCAAGACTCT 
TTTGAACAAC GATTTTTGCA AGAAACTAAT CGGCTTTATG CGGCCGAAGG TCAGAAGTTA 
ATGCAAGAAA GAGAGGTTCC TGAGTATCTT CATCATGTTA ATAAACGCCT AGAAGAAGAA 
GCAGACAGAC TTATTACTTA CTTAGATCAG ACCACCCAGA AGTCACTGAT TGCTTCTGTT 
GAAAAACAAC TTCTAGGTGA ACACTTAACA GCAATTCTTC AGAAAGGTTT AAATAGCCTC 
CTTGATGAAA ACCGAATTCA AGATCTGTCT CTCCTGTATC AGCTCTTCAG TAGAGTTCGG 
GGAGGAGTTC AGGTTCTCCT ACAGCACTGG ATTGAGTATA TCAAGGCTTT TGGAAGTACC 
ATTGTTATTA ATCCTGAAAA AGATAAAACT ATGGTTCAAG AATTATTGGA CTTTAAAGAT 
AAAGTTGACC ATATAATTGA TACCTGCTTT CTGAAAAATG AAAAATTTAT CAATGCCATG 
AAAGAAGCAT TTGAAACCTT CATTAATAAA AGACCAAATA AGCCAGCTGA ACTGATAGCT 
AAGTATGTGG ATTCAAAACT TCGTGCAGGC AACAAAGAAG CTACAGATGA AGAGCTTGAG 
AAAATGTTGG ATAAAATAAT GATTATATTT AGATTTATCT ATGGCAAAGA TGTTTTTGAG 
GCCTTCTATA AGAAAGACTT AGCCAAACGC CTATTAGTTG GCAAGAGTGC ATCAGTGGAT 
GCTGAAAAAT CAATGCTGTC CAAACTGAAA CACGAATGTG GAGCCGCTTT TACCAGCAAG 
CTTGAAGGCA TGTTTAAAGA CATGGAGCTT TCTAAAGATA TCATGATCCA GTTCAAACAG 
TATATGCAGA ACCAGAATGT ACCTGGCAAT ATTGAATTAA CTGTTAATAT CCTGACAATG 
GGTTATTGGC CAACATATGT GCCTATGGAA GTCCATTTGC CACCAGAGAT GGTGAAGCTT 
CAGGAAATTT TCAAGACATT TTACTTAGGC AAGCACAGTG GCAGGAAACT TCAATGGCAA 
TCAACCTTGG GACACTGTGT GCTAAAAGCT GAATTTAAAG AGGGCAAAAA AGAACTTCAG 
GTCTCTCTTT TTCAAACCCT GGTGCTACTA ATGTTTAATG AAGGAGAGGA GTTCAGTTTA 
GAGGAGATAA AGCAAGCCAC TGGAATAGAG GATGGAGAAT TAAGAAGAAC ACTGCAGTCA 
CTAGCCTGTG GCAAAGCTAG AGTTCTGGCT AAAAATCCAA AGGGCAAAGA TATTGAAGAT 
GGTGACAAGT TTATTTGTAA TGATGATTTC AAACACAAAC TATTCAGGAT AAAGATCAAT 
CAAATCCAGA TGAAAGAAAC GGTTGAAGAA CAAGCAAGCA CTACAGAAAG AGTATTTCAA 
GATAGACAGT ACCAAATTGA TGCTGCGATC GTCCGAATTA TGAAGATGAG AAAAACACTT 
AGCCACAACC TTCTTGTTTC AGAAGTCTAC AATCAGCTAA AATTTCCAGT AAAACCTGCT 
GATCTTAAGA AGAGAATAGA ATCCCTAATT GACCGGGACT ACATGGAAAG AGATAAAGAA 
AACCCAAATC AGTACAACTA TATTGCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

CUL4B promotes the pathology of adjuvant-induced arthritis in rats through the canonical Wnt signaling.
Journal of molecular medicine (Berlin, Germany)96(6)495-511(2018 06)
Miao C,Chang J,Zhang G,Yu H,Zhou L,Zhou G,Zhao C

Selective degradation of splicing factor CAPERα by anticancer sulfonamides.
Nature chemical biology13(6)675-680(2017 06)
Uehara T,Minoshima Y,Sagane K,Sugi NH,Mitsuhashi KO,Yamamoto N,Kamiyama H,Takahashi K,Kotake Y,Uesugi M,Yokoi A,Inoue A,Yoshida T,Mabuchi M,Tanaka A,Owa T

Genome-wide RNAi Screening Identifies Protein Modules Required for 40S Subunit Synthesis in Human Cells.
Cell reports13(12)2879-91(2015 Dec)
Badertscher L,Wild T,Montellese C,Alexander LT,Bammert L,Sarazova M,Stebler M,Csucs G,Mayer TU,Zamboni N,Zemp I,Horvath P,Kutay U

FBXO44-Mediated Degradation of RGS2 Protein Uniquely Depends on a Cullin 4B/DDB1 Complex.
PloS one10(5)e0123581(2015)
Sjögren B,Swaney S,Neubig RR

Monoubiquitinated histone H2A destabilizes photolesion-containing nucleosomes with concomitant release of UV-damaged DNA-binding protein E3 ligase.
The Journal of biological chemistry287(15)12036-49(2012 Apr)
Lan L,Nakajima S,Kapetanaki MG,Hsieh CL,Fagerburg M,Thickman K,Rodriguez-Collazo P,Leuba SH,Levine AS,Rapić-Otrin V

REQUEST A QUOTE

EMAIL

gene@genscript.com

PHONE

1-877-436-7274

ONLINE FORM

Online Quote Submission

ONLINE FORM

Online Quote Submission

Cul4b cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

News & Blogs

REQUEST A QUOTE

EMAIL

PHONE

ONLINE FORM

ONLINE FORM