Cul4b cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cul4b
Entrez Gene ID	72584
Full Name	cullin 4B
Synonyms	2700050M05Rik,AA409770,CUL-4B,mKIAA0695
General protein information	Preferred Names cullin 4B Names cullin-4B cul4b
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: X Map Location: X\|X A3.3

mRNA and Protein(s)

mRNA	Protein	Name
NM_028288.5	NP_082564.3	cullin-4B
NM_001110142.1	NP_001103612.1	cullin-4B

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	CUL4B	XP_864628.3
Mus musculus (house mouse)	Cul4b	NP_001103612.1
Danio rerio (zebrafish)	cul4b	NP_001116316.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007727	XP_308149.4
Homo sapiens (human)	CUL4B	NP_001073341.1
Macaca mulatta (Rhesus monkey)	CUL4B	XP_001086195.1
Gallus gallus (chicken)	CUL4B	XP_420335.2
Rattus norvegicus (Norway rat)	Cul4b	NP_001100421.1
Arabidopsis thaliana (thale cress)	CUL4	NP_568658.1
Xenopus tropicalis (tropical clawed frog)	cul4b	NP_001120891.1
Bos taurus (cattle)	CUL4B	XP_005227530.1
Drosophila melanogaster (fruit fly)	Cul-4	NP_001163084.1

Gene Ontology
Bibliography

Related articles in PubMed

Upregulation of IL-6 in CUL4B-deficient myeloid-derived suppressive cells increases the aggressiveness of cancer cells.
Xu Z, Li L, Qian Y, Song Y, Qin L, Duan Y, Wang M, Li P, Jiang B, Ma C, Shao C, Gong Y
Oncogene38(30)5860-5872(2019 07)

Abnormal level of CUL4B-mediated histone H2A ubiquitination causes disruptive HOX gene expression.
Lin Y, Yu J, Wu J, Wang S, Zhang T
Epigenetics & chromatin12(1)22(2019 04)

Embryonic Cul4b is important for epiblast growth and location of primitive streak layer cells.
Chen CY, Yu IS, Pai CH, Lin CY, Lin SR, Chen YT, Lin SW
PloS one14(7)e0219221(2019)

CUL4B promotes gastric cancer invasion and metastasis-involvement of upregulation of HER2.
Qi M, Jiao M, Li X, Hu J, Wang L, Zou Y, Zhao M, Zhang R, Liu H, Mi J, Zhang L, Liu L, Gong Y, Han B
Oncogene37(8)1075-1085(2018 02)

A cullin 4B-RING E3 ligase complex fine-tunes pancreatic δ cell paracrine interactions.
Li Q, Cui M, Yang F, Li N, Jiang B, Yu Z, Zhang D, Wang Y, Zhu X, Hu H, Li PS, Ning SL, Wang S, Qi H, Song H, He D, Lin A, Zhang J, Liu F, Zhao J, Gao L, Yi F, Xue T, Sun JP, Gong Y, Yu X
The Journal of clinical investigation127(7)2631-2646(2017 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Cul4b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cul4b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu22206	NM_001110142.1 Latest version!	Mus musculus cullin 4B (Cul4b), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00
OMu22206	NM_028288.5 Latest version!	Mus musculus cullin 4B (Cul4b), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cul4b ( NM_028288.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_082564.3 Mus musculus cullin 4B (Cul4b), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu22206
Clone ID Related Accession (Same CDS sequence)	NM_028288.5 , NM_001110142.1
Accession Version	NM_028288.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2913bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577203200000
Organism	Mus musculus(house mouse)
Product	cullin-4B
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK032701.1, AK160998.1, AK164640.1 and AI037712.1. On Oct 26, 2007 this sequence version replaced NM_028288.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY330868.1, AK032701.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END##

ATGTCACGTT CAACTAGGTC TAAAGAAAGA AGAGAGAATG ACACCGACTC AGAAGATAAC 
AGTTCGGAAA CCTCCAATCA AGAGCGCCGA AGGTGTCGCC AAGGTCCGCC CCGCCCTCCC 
TATCCACCTC TTTTACCCCC CGTGTTCCCT CCCCCAACCC CCCCACCTCA AGTCCGGCGG 
ACCCGGGGGC TTCAGGATCT GGGAGCTATG AAAAGTGTCT GCCCAGGCAC TTCCGGTTTT 
TCTTCCCCCA ATCCCTCTGC TGCTTCTGCT GCTGCTCAGG AGGTCAGATC TGCCACTGAT 
GGTAATACCA GCACCACTCC GCCCACCTCT GCCAAGAAGA GAAAGTTAAA CAGCAGCAGT 
AGCAGCAGTA ACAGTAGTAA CGAGAGAGAA GACTTTGATT CCACCTCTTC CTCTTCCACC 
CCTCCACAAC CCAGAGATTC GGCGTCCCCT TCAACCTCGT CCTTCTGCCT TGGGGTTCCA 
GTGGCCACTT CCAGCCACGT ACCTATACAG AAGAAGCTGC GGTTTGAAGA CACCCTGGAG 
TTTGTAGGGA TTGATACGAA AATGGCTGAG GAATCTTCCT CCTCATCTTC CTCATCTTCG 
CCAACTGCTG CAACCTCACA GCAGCAGCAG CAGCAACAAC TTAAAACTAA GAGTATATTA 
ATTTCTTCTG TGGCTTCAGT GCACCATGCA AACGGCCTGG CTAAATCTTC TACCGCGGTC 
TCTAGCTTTG CTAACAGCAA GCCCGGCTCA GCTAAGAAGT TAGTGATCAA GAACTTTAAA 
GATAAGCCTA AATTACCAGA AAACTATACG GATGAGACAT GGCAAAAGCT AAAAGAAGCA 
GTGGAAGCCA TTCAGAATAG TACTTCAATT AAGTACAATT TAGAAGAACT CTACCAGGCT 
GTAGAAAATC TTTGTTCTCA TAAGATTTCT GCAAATTTGT ATAAGCAGCT GAGGCAGATA 
TGTGAAGATC ACATCAAAGC ACAGATTCAT CAGTTCAGAG AGGATTCATT GGATAGTGTT 
CTTTTTCTCA AAAAGATCGA TAGATGCTGG CAAAACCACT GTAGGCAAAT GATAATGATC 
AGGAGCATTT TTTTGTTTCT GGATAGAACT TATGTTCTTC AGAATTCAAT GCTACCCTCC 
ATTTGGGACA TGGGATTAGA GTTATTTAGG GCTCATATTA TAAGTGATCA AAAAGTACAG 
ACAAAAACGA TTGATGGCAT CCTTCTCTTG ATTGAGAGAG AGCGGAATGG TGAAGCAATT 
GATAGAAGTT TACTTCGAAG CCTTTTAAGT ATGCTGTCTG ATTTGCAAAT TTACCAAGAT 
TCTTTTGAAC AGCAATTTTT GCAAGAAACT AATCGGCTTT ACGCAGCCGA AGGTCAGAAG 
TTAATGCAAG AAAGAGAGGT TCCTGAGTAT CTTCATCATG TTAATAAACG CCTAGAAGAA 
GAAGCTGACA GACTTATTAC TTACTTAGAT CAGACCACCC AGAAGTCACT AATTGCTTCT 
GTTGAAAAAC AACTTCTAGG TGAACACTTA ACGGCAATTC TTCAAAAAGG TTTAAATAGC 
CTCCTTGATG AAAACCGAAT TCAAGATTTG TCTCTCCTGT ATCAGCTCTT CAGTAGAGTT 
CGGGGTGGAG TTCAGGTTCT CTTACAGCAG TGGATTGAGT ATATCAAGGC TTTTGGAAGT 
ACCATTGTTA TTAATCCTGA AAAAGATAAA ACTATGGTTC AAGAATTATT GGACTTTAAA 
GATAAAGTTG ACCATATAAT TGATACCTGC TTTCTGAAAA ATGAAAAATT TATCAATGCC 
ATGAAAGAAG CTTTTGAAAC ATTCATTAAT AAAAGACCAA ATAAGCCAGC TGAACTGATA 
GCTAAGTATG TGGATTCAAA ACTTCGTGCA GGCAACAAAG AAGCTACAGA TGAAGAGCTT 
GAGAAAATGT TGGATAAAAT AATGATTATA TTTAGATTTA TCTATGGTAA AGATGTTTTT 
GAGGCCTTCT ATAAGAAAGA TTTAGCCAAA CGCCTATTAG TTGGCAAGAG TGCATCAGTA 
GATGCTGAAA AATCAATGCT GTCCAAACTG AAACACGAAT GTGGAGCCGC TTTTACCAGC 
AAGCTTGAAG GAATGTTCAA AGACATGGAG CTTTCTAAAG ATATCATGAT TCAGTTTAAA 
CAGTATATGC AGAACCAGAA TGTACCTGGC AATATTGAAT TAACTGTTAA TATCCTGACA 
ATGGGTTACT GGCCAACATA TGTGCCTATG GAAGTCCATT TGCCGCCAGA GATGGTAAAG 
CTTCAGGAAA TTTTCAAGAC ATTTTACTTA GGCAAGCACA GTGGCAGGAA ACTCCAGTGG 
CAGTCAACCT TGGGACACTG TGTGCTAAAA GCTGAATTTA AAGAGGGCAA AAAAGAACTT 
CAGGTCTCTC TTTTTCAAAC CATGGTGCTG CTAATGTTTA ATGAAGGAGA AGAATTCAGT 
TTAGAAGAGA TCAAGCATGC TACTGGGATA GAGGATGGAG AATTAAGAAG AACACTGCAG 
TCACTAGCCT GTGGCAAAGC TAGAGTTCTG GCTAAAAATC CTAAGGGCAA AGATATTGAA 
GATGGTGACA AATTTATTTG TAATGACGAT TTCAAACACA AACTATTCAG GATAAAGATC 
AATCAAATCC AGATGAAAGA AACGGTTGAA GAACAAGCAA GCACTACAGA AAGAGTATTT 
CAAGACAGAC AGTACCAAAT TGATGCTGCG ATCGTTCGAA TTATGAAGAT GAGAAAAACA 
CTTAGCCACA ATCTTCTTGT TTCAGAAGTC TACAATCAGC TAAAATTTCC AGTTAAACCT 
GCTGATCTTA AGAAGAGAAT AGAATCCCTC ATTGACCGGG ACTACATGGA AAGAGATAAA 
GAAAATCCAA ATCAGTACAA CTATATTGCA TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_082564.3
CDS	73..2985
Translation	MSRSTRSKERRENDTDSEDNSSETSNQERRRCRQGPPRPPYPPLLPPVFPPPTPPPQVRRTRGLQDLGAMKSVCPGTSGFSSPNPSAASAAAQEVRSATDGNTSTTPPTSAKKRKLNSSSSSSNSSNEREDFDSTSSSSTPPQPRDSASPSTSSFCLGVPVATSSHVPIQKKLRFEDTLEFVGIDTKMAEESSSSSSSSSPTAATSQQQQQQQLKTKSILISSVASVHHANGLAKSSTAVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEELYQAVENLCSHKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQTKTIDGILLLIERERNGEAIDRSLLRSLLSMLSDLQIYQDSFEQQFLQETNRLYAAEGQKLMQEREVPEYLHHVNKRLEEEADRLITYLDQTTQKSLIASVEKQLLGEHLTAILQKGLNSLLDENRIQDLSLLYQLFSRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDTCFLKNEKFINAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKEGKKELQVSLFQTMVLLMFNEGEEFSLEEIKHATGIEDGELRRTLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDYMERDKENPNQYNYIA

Target ORF information:

RefSeq Version	NM_028288.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus cullin 4B (Cul4b), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_028288.5

ORF Insert Sequence:

ATGTCACGTT CAACTAGGTC TAAAGAAAGA AGAGAGAATG ACACCGACTC AGAAGATAAC 
AGTTCGGAAA CCTCCAATCA AGAGCGCCGA AGGTGTCGCC AAGGTCCGCC CCGCCCTCCC 
TATCCACCTC TTTTACCCCC CGTGTTCCCT CCCCCAACCC CCCCACCTCA AGTCCGGCGG 
ACCCGGGGGC TTCAGGATCT GGGAGCTATG AAAAGTGTCT GCCCAGGCAC TTCCGGTTTT 
TCTTCCCCCA ATCCCTCTGC TGCTTCTGCT GCTGCTCAGG AGGTCAGATC TGCCACTGAT 
GGTAATACCA GCACCACTCC GCCCACCTCT GCCAAGAAGA GAAAGTTAAA CAGCAGCAGT 
AGCAGCAGTA ACAGTAGTAA CGAGAGAGAA GACTTTGATT CCACCTCTTC CTCTTCCACC 
CCTCCACAAC CCAGAGATTC GGCGTCCCCT TCAACCTCGT CCTTCTGCCT TGGGGTTCCA 
GTGGCCACTT CCAGCCACGT ACCTATACAG AAGAAGCTGC GGTTTGAAGA CACCCTGGAG 
TTTGTAGGGA TTGATACGAA AATGGCTGAG GAATCTTCCT CCTCATCTTC CTCATCTTCG 
CCAACTGCTG CAACCTCACA GCAGCAGCAG CAGCAACAAC TTAAAACTAA GAGTATATTA 
ATTTCTTCTG TGGCTTCAGT GCACCATGCA AACGGCCTGG CTAAATCTTC TACCGCGGTC 
TCTAGCTTTG CTAACAGCAA GCCCGGCTCA GCTAAGAAGT TAGTGATCAA GAACTTTAAA 
GATAAGCCTA AATTACCAGA AAACTATACG GATGAGACAT GGCAAAAGCT AAAAGAAGCA 
GTGGAAGCCA TTCAGAATAG TACTTCAATT AAGTACAATT TAGAAGAACT CTACCAGGCT 
GTAGAAAATC TTTGTTCTCA TAAGATTTCT GCAAATTTGT ATAAGCAGCT GAGGCAGATA 
TGTGAAGATC ACATCAAAGC ACAGATTCAT CAGTTCAGAG AGGATTCATT GGATAGTGTT 
CTTTTTCTCA AAAAGATCGA TAGATGCTGG CAAAACCACT GTAGGCAAAT GATAATGATC 
AGGAGCATTT TTTTGTTTCT GGATAGAACT TATGTTCTTC AGAATTCAAT GCTACCCTCC 
ATTTGGGACA TGGGATTAGA GTTATTTAGG GCTCATATTA TAAGTGATCA AAAAGTACAG 
ACAAAAACGA TTGATGGCAT CCTTCTCTTG ATTGAGAGAG AGCGGAATGG TGAAGCAATT 
GATAGAAGTT TACTTCGAAG CCTTTTAAGT ATGCTGTCTG ATTTGCAAAT TTACCAAGAT 
TCTTTTGAAC AGCAATTTTT GCAAGAAACT AATCGGCTTT ACGCAGCCGA AGGTCAGAAG 
TTAATGCAAG AAAGAGAGGT TCCTGAGTAT CTTCATCATG TTAATAAACG CCTAGAAGAA 
GAAGCTGACA GACTTATTAC TTACTTAGAT CAGACCACCC AGAAGTCACT AATTGCTTCT 
GTTGAAAAAC AACTTCTAGG TGAACACTTA ACGGCAATTC TTCAAAAAGG TTTAAATAGC 
CTCCTTGATG AAAACCGAAT TCAAGATTTG TCTCTCCTGT ATCAGCTCTT CAGTAGAGTT 
CGGGGTGGAG TTCAGGTTCT CTTACAGCAG TGGATTGAGT ATATCAAGGC TTTTGGAAGT 
ACCATTGTTA TTAATCCTGA AAAAGATAAA ACTATGGTTC AAGAATTATT GGACTTTAAA 
GATAAAGTTG ACCATATAAT TGATACCTGC TTTCTGAAAA ATGAAAAATT TATCAATGCC 
ATGAAAGAAG CTTTTGAAAC ATTCATTAAT AAAAGACCAA ATAAGCCAGC TGAACTGATA 
GCTAAGTATG TGGATTCAAA ACTTCGTGCA GGCAACAAAG AAGCTACAGA TGAAGAGCTT 
GAGAAAATGT TGGATAAAAT AATGATTATA TTTAGATTTA TCTATGGTAA AGATGTTTTT 
GAGGCCTTCT ATAAGAAAGA TTTAGCCAAA CGCCTATTAG TTGGCAAGAG TGCATCAGTA 
GATGCTGAAA AATCAATGCT GTCCAAACTG AAACACGAAT GTGGAGCCGC TTTTACCAGC 
AAGCTTGAAG GAATGTTCAA AGACATGGAG CTTTCTAAAG ATATCATGAT TCAGTTTAAA 
CAGTATATGC AGAACCAGAA TGTACCTGGC AATATTGAAT TAACTGTTAA TATCCTGACA 
ATGGGTTACT GGCCAACATA TGTGCCTATG GAAGTCCATT TGCCGCCAGA GATGGTAAAG 
CTTCAGGAAA TTTTCAAGAC ATTTTACTTA GGCAAGCACA GTGGCAGGAA ACTCCAGTGG 
CAGTCAACCT TGGGACACTG TGTGCTAAAA GCTGAATTTA AAGAGGGCAA AAAAGAACTT 
CAGGTCTCTC TTTTTCAAAC CATGGTGCTG CTAATGTTTA ATGAAGGAGA AGAATTCAGT 
TTAGAAGAGA TCAAGCATGC TACTGGGATA GAGGATGGAG AATTAAGAAG AACACTGCAG 
TCACTAGCCT GTGGCAAAGC TAGAGTTCTG GCTAAAAATC CTAAGGGCAA AGATATTGAA 
GATGGTGACA AATTTATTTG TAATGACGAT TTCAAACACA AACTATTCAG GATAAAGATC 
AATCAAATCC AGATGAAAGA AACGGTTGAA GAACAAGCAA GCACTACAGA AAGAGTATTT 
CAAGACAGAC AGTACCAAAT TGATGCTGCG ATCGTTCGAA TTATGAAGAT GAGAAAAACA 
CTTAGCCACA ATCTTCTTGT TTCAGAAGTC TACAATCAGC TAAAATTTCC AGTTAAACCT 
GCTGATCTTA AGAAGAGAAT AGAATCCCTC ATTGACCGGG ACTACATGGA AAGAGATAAA 
GAAAATCCAA ATCAGTACAA CTATATTGCA TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cul4b ( NM_001110142.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001103612.1 Mus musculus cullin 4B (Cul4b), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu22206
Clone ID Related Accession (Same CDS sequence)	NM_028288.5 , NM_001110142.1
Accession Version	NM_001110142.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2913bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577203200000
Organism	Mus musculus(house mouse)
Product	cullin-4B
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK032701.1, CJ072585.1, AK160998.1, AK164640.1 and AI037712.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC004026.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END##

ATGTCACGTT CAACTAGGTC TAAAGAAAGA AGAGAGAATG ACACCGACTC AGAAGATAAC 
AGTTCGGAAA CCTCCAATCA AGAGCGCCGA AGGTGTCGCC AAGGTCCGCC CCGCCCTCCC 
TATCCACCTC TTTTACCCCC CGTGTTCCCT CCCCCAACCC CCCCACCTCA AGTCCGGCGG 
ACCCGGGGGC TTCAGGATCT GGGAGCTATG AAAAGTGTCT GCCCAGGCAC TTCCGGTTTT 
TCTTCCCCCA ATCCCTCTGC TGCTTCTGCT GCTGCTCAGG AGGTCAGATC TGCCACTGAT 
GGTAATACCA GCACCACTCC GCCCACCTCT GCCAAGAAGA GAAAGTTAAA CAGCAGCAGT 
AGCAGCAGTA ACAGTAGTAA CGAGAGAGAA GACTTTGATT CCACCTCTTC CTCTTCCACC 
CCTCCACAAC CCAGAGATTC GGCGTCCCCT TCAACCTCGT CCTTCTGCCT TGGGGTTCCA 
GTGGCCACTT CCAGCCACGT ACCTATACAG AAGAAGCTGC GGTTTGAAGA CACCCTGGAG 
TTTGTAGGGA TTGATACGAA AATGGCTGAG GAATCTTCCT CCTCATCTTC CTCATCTTCG 
CCAACTGCTG CAACCTCACA GCAGCAGCAG CAGCAACAAC TTAAAACTAA GAGTATATTA 
ATTTCTTCTG TGGCTTCAGT GCACCATGCA AACGGCCTGG CTAAATCTTC TACCGCGGTC 
TCTAGCTTTG CTAACAGCAA GCCCGGCTCA GCTAAGAAGT TAGTGATCAA GAACTTTAAA 
GATAAGCCTA AATTACCAGA AAACTATACG GATGAGACAT GGCAAAAGCT AAAAGAAGCA 
GTGGAAGCCA TTCAGAATAG TACTTCAATT AAGTACAATT TAGAAGAACT CTACCAGGCT 
GTAGAAAATC TTTGTTCTCA TAAGATTTCT GCAAATTTGT ATAAGCAGCT GAGGCAGATA 
TGTGAAGATC ACATCAAAGC ACAGATTCAT CAGTTCAGAG AGGATTCATT GGATAGTGTT 
CTTTTTCTCA AAAAGATCGA TAGATGCTGG CAAAACCACT GTAGGCAAAT GATAATGATC 
AGGAGCATTT TTTTGTTTCT GGATAGAACT TATGTTCTTC AGAATTCAAT GCTACCCTCC 
ATTTGGGACA TGGGATTAGA GTTATTTAGG GCTCATATTA TAAGTGATCA AAAAGTACAG 
ACAAAAACGA TTGATGGCAT CCTTCTCTTG ATTGAGAGAG AGCGGAATGG TGAAGCAATT 
GATAGAAGTT TACTTCGAAG CCTTTTAAGT ATGCTGTCTG ATTTGCAAAT TTACCAAGAT 
TCTTTTGAAC AGCAATTTTT GCAAGAAACT AATCGGCTTT ACGCAGCCGA AGGTCAGAAG 
TTAATGCAAG AAAGAGAGGT TCCTGAGTAT CTTCATCATG TTAATAAACG CCTAGAAGAA 
GAAGCTGACA GACTTATTAC TTACTTAGAT CAGACCACCC AGAAGTCACT AATTGCTTCT 
GTTGAAAAAC AACTTCTAGG TGAACACTTA ACGGCAATTC TTCAAAAAGG TTTAAATAGC 
CTCCTTGATG AAAACCGAAT TCAAGATTTG TCTCTCCTGT ATCAGCTCTT CAGTAGAGTT 
CGGGGTGGAG TTCAGGTTCT CTTACAGCAG TGGATTGAGT ATATCAAGGC TTTTGGAAGT 
ACCATTGTTA TTAATCCTGA AAAAGATAAA ACTATGGTTC AAGAATTATT GGACTTTAAA 
GATAAAGTTG ACCATATAAT TGATACCTGC TTTCTGAAAA ATGAAAAATT TATCAATGCC 
ATGAAAGAAG CTTTTGAAAC ATTCATTAAT AAAAGACCAA ATAAGCCAGC TGAACTGATA 
GCTAAGTATG TGGATTCAAA ACTTCGTGCA GGCAACAAAG AAGCTACAGA TGAAGAGCTT 
GAGAAAATGT TGGATAAAAT AATGATTATA TTTAGATTTA TCTATGGTAA AGATGTTTTT 
GAGGCCTTCT ATAAGAAAGA TTTAGCCAAA CGCCTATTAG TTGGCAAGAG TGCATCAGTA 
GATGCTGAAA AATCAATGCT GTCCAAACTG AAACACGAAT GTGGAGCCGC TTTTACCAGC 
AAGCTTGAAG GAATGTTCAA AGACATGGAG CTTTCTAAAG ATATCATGAT TCAGTTTAAA 
CAGTATATGC AGAACCAGAA TGTACCTGGC AATATTGAAT TAACTGTTAA TATCCTGACA 
ATGGGTTACT GGCCAACATA TGTGCCTATG GAAGTCCATT TGCCGCCAGA GATGGTAAAG 
CTTCAGGAAA TTTTCAAGAC ATTTTACTTA GGCAAGCACA GTGGCAGGAA ACTCCAGTGG 
CAGTCAACCT TGGGACACTG TGTGCTAAAA GCTGAATTTA AAGAGGGCAA AAAAGAACTT 
CAGGTCTCTC TTTTTCAAAC CATGGTGCTG CTAATGTTTA ATGAAGGAGA AGAATTCAGT 
TTAGAAGAGA TCAAGCATGC TACTGGGATA GAGGATGGAG AATTAAGAAG AACACTGCAG 
TCACTAGCCT GTGGCAAAGC TAGAGTTCTG GCTAAAAATC CTAAGGGCAA AGATATTGAA 
GATGGTGACA AATTTATTTG TAATGACGAT TTCAAACACA AACTATTCAG GATAAAGATC 
AATCAAATCC AGATGAAAGA AACGGTTGAA GAACAAGCAA GCACTACAGA AAGAGTATTT 
CAAGACAGAC AGTACCAAAT TGATGCTGCG ATCGTTCGAA TTATGAAGAT GAGAAAAACA 
CTTAGCCACA ATCTTCTTGT TTCAGAAGTC TACAATCAGC TAAAATTTCC AGTTAAACCT 
GCTGATCTTA AGAAGAGAAT AGAATCCCTC ATTGACCGGG ACTACATGGA AAGAGATAAA 
GAAAATCCAA ATCAGTACAA CTATATTGCA TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001103612.1
CDS	132..3044
Translation	MSRSTRSKERRENDTDSEDNSSETSNQERRRCRQGPPRPPYPPLLPPVFPPPTPPPQVRRTRGLQDLGAMKSVCPGTSGFSSPNPSAASAAAQEVRSATDGNTSTTPPTSAKKRKLNSSSSSSNSSNEREDFDSTSSSSTPPQPRDSASPSTSSFCLGVPVATSSHVPIQKKLRFEDTLEFVGIDTKMAEESSSSSSSSSPTAATSQQQQQQQLKTKSILISSVASVHHANGLAKSSTAVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEELYQAVENLCSHKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQTKTIDGILLLIERERNGEAIDRSLLRSLLSMLSDLQIYQDSFEQQFLQETNRLYAAEGQKLMQEREVPEYLHHVNKRLEEEADRLITYLDQTTQKSLIASVEKQLLGEHLTAILQKGLNSLLDENRIQDLSLLYQLFSRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDTCFLKNEKFINAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKEGKKELQVSLFQTMVLLMFNEGEEFSLEEIKHATGIEDGELRRTLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDYMERDKENPNQYNYIA

Target ORF information:

RefSeq Version	NM_001110142.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus cullin 4B (Cul4b), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001110142.1

ORF Insert Sequence:

ATGTCACGTT CAACTAGGTC TAAAGAAAGA AGAGAGAATG ACACCGACTC AGAAGATAAC 
AGTTCGGAAA CCTCCAATCA AGAGCGCCGA AGGTGTCGCC AAGGTCCGCC CCGCCCTCCC 
TATCCACCTC TTTTACCCCC CGTGTTCCCT CCCCCAACCC CCCCACCTCA AGTCCGGCGG 
ACCCGGGGGC TTCAGGATCT GGGAGCTATG AAAAGTGTCT GCCCAGGCAC TTCCGGTTTT 
TCTTCCCCCA ATCCCTCTGC TGCTTCTGCT GCTGCTCAGG AGGTCAGATC TGCCACTGAT 
GGTAATACCA GCACCACTCC GCCCACCTCT GCCAAGAAGA GAAAGTTAAA CAGCAGCAGT 
AGCAGCAGTA ACAGTAGTAA CGAGAGAGAA GACTTTGATT CCACCTCTTC CTCTTCCACC 
CCTCCACAAC CCAGAGATTC GGCGTCCCCT TCAACCTCGT CCTTCTGCCT TGGGGTTCCA 
GTGGCCACTT CCAGCCACGT ACCTATACAG AAGAAGCTGC GGTTTGAAGA CACCCTGGAG 
TTTGTAGGGA TTGATACGAA AATGGCTGAG GAATCTTCCT CCTCATCTTC CTCATCTTCG 
CCAACTGCTG CAACCTCACA GCAGCAGCAG CAGCAACAAC TTAAAACTAA GAGTATATTA 
ATTTCTTCTG TGGCTTCAGT GCACCATGCA AACGGCCTGG CTAAATCTTC TACCGCGGTC 
TCTAGCTTTG CTAACAGCAA GCCCGGCTCA GCTAAGAAGT TAGTGATCAA GAACTTTAAA 
GATAAGCCTA AATTACCAGA AAACTATACG GATGAGACAT GGCAAAAGCT AAAAGAAGCA 
GTGGAAGCCA TTCAGAATAG TACTTCAATT AAGTACAATT TAGAAGAACT CTACCAGGCT 
GTAGAAAATC TTTGTTCTCA TAAGATTTCT GCAAATTTGT ATAAGCAGCT GAGGCAGATA 
TGTGAAGATC ACATCAAAGC ACAGATTCAT CAGTTCAGAG AGGATTCATT GGATAGTGTT 
CTTTTTCTCA AAAAGATCGA TAGATGCTGG CAAAACCACT GTAGGCAAAT GATAATGATC 
AGGAGCATTT TTTTGTTTCT GGATAGAACT TATGTTCTTC AGAATTCAAT GCTACCCTCC 
ATTTGGGACA TGGGATTAGA GTTATTTAGG GCTCATATTA TAAGTGATCA AAAAGTACAG 
ACAAAAACGA TTGATGGCAT CCTTCTCTTG ATTGAGAGAG AGCGGAATGG TGAAGCAATT 
GATAGAAGTT TACTTCGAAG CCTTTTAAGT ATGCTGTCTG ATTTGCAAAT TTACCAAGAT 
TCTTTTGAAC AGCAATTTTT GCAAGAAACT AATCGGCTTT ACGCAGCCGA AGGTCAGAAG 
TTAATGCAAG AAAGAGAGGT TCCTGAGTAT CTTCATCATG TTAATAAACG CCTAGAAGAA 
GAAGCTGACA GACTTATTAC TTACTTAGAT CAGACCACCC AGAAGTCACT AATTGCTTCT 
GTTGAAAAAC AACTTCTAGG TGAACACTTA ACGGCAATTC TTCAAAAAGG TTTAAATAGC 
CTCCTTGATG AAAACCGAAT TCAAGATTTG TCTCTCCTGT ATCAGCTCTT CAGTAGAGTT 
CGGGGTGGAG TTCAGGTTCT CTTACAGCAG TGGATTGAGT ATATCAAGGC TTTTGGAAGT 
ACCATTGTTA TTAATCCTGA AAAAGATAAA ACTATGGTTC AAGAATTATT GGACTTTAAA 
GATAAAGTTG ACCATATAAT TGATACCTGC TTTCTGAAAA ATGAAAAATT TATCAATGCC 
ATGAAAGAAG CTTTTGAAAC ATTCATTAAT AAAAGACCAA ATAAGCCAGC TGAACTGATA 
GCTAAGTATG TGGATTCAAA ACTTCGTGCA GGCAACAAAG AAGCTACAGA TGAAGAGCTT 
GAGAAAATGT TGGATAAAAT AATGATTATA TTTAGATTTA TCTATGGTAA AGATGTTTTT 
GAGGCCTTCT ATAAGAAAGA TTTAGCCAAA CGCCTATTAG TTGGCAAGAG TGCATCAGTA 
GATGCTGAAA AATCAATGCT GTCCAAACTG AAACACGAAT GTGGAGCCGC TTTTACCAGC 
AAGCTTGAAG GAATGTTCAA AGACATGGAG CTTTCTAAAG ATATCATGAT TCAGTTTAAA 
CAGTATATGC AGAACCAGAA TGTACCTGGC AATATTGAAT TAACTGTTAA TATCCTGACA 
ATGGGTTACT GGCCAACATA TGTGCCTATG GAAGTCCATT TGCCGCCAGA GATGGTAAAG 
CTTCAGGAAA TTTTCAAGAC ATTTTACTTA GGCAAGCACA GTGGCAGGAA ACTCCAGTGG 
CAGTCAACCT TGGGACACTG TGTGCTAAAA GCTGAATTTA AAGAGGGCAA AAAAGAACTT 
CAGGTCTCTC TTTTTCAAAC CATGGTGCTG CTAATGTTTA ATGAAGGAGA AGAATTCAGT 
TTAGAAGAGA TCAAGCATGC TACTGGGATA GAGGATGGAG AATTAAGAAG AACACTGCAG 
TCACTAGCCT GTGGCAAAGC TAGAGTTCTG GCTAAAAATC CTAAGGGCAA AGATATTGAA 
GATGGTGACA AATTTATTTG TAATGACGAT TTCAAACACA AACTATTCAG GATAAAGATC 
AATCAAATCC AGATGAAAGA AACGGTTGAA GAACAAGCAA GCACTACAGA AAGAGTATTT 
CAAGACAGAC AGTACCAAAT TGATGCTGCG ATCGTTCGAA TTATGAAGAT GAGAAAAACA 
CTTAGCCACA ATCTTCTTGT TTCAGAAGTC TACAATCAGC TAAAATTTCC AGTTAAACCT 
GCTGATCTTA AGAAGAGAAT AGAATCCCTC ATTGACCGGG ACTACATGGA AAGAGATAAA 
GAAAATCCAA ATCAGTACAA CTATATTGCA TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Upregulation of IL-6 in CUL4B-deficient myeloid-derived suppressive cells increases the aggressiveness of cancer cells.
Oncogene38(30)5860-5872(2019 07)
Xu Z,Li L,Qian Y,Song Y,Qin L,Duan Y,Wang M,Li P,Jiang B,Ma C,Shao C,Gong Y

Abnormal level of CUL4B-mediated histone H2A ubiquitination causes disruptive HOX gene expression.
Epigenetics & chromatin12(1)22(2019 04)
Lin Y,Yu J,Wu J,Wang S,Zhang T

Embryonic Cul4b is important for epiblast growth and location of primitive streak layer cells.
PloS one14(7)e0219221(2019)
Chen CY,Yu IS,Pai CH,Lin CY,Lin SR,Chen YT,Lin SW

CUL4B promotes gastric cancer invasion and metastasis-involvement of upregulation of HER2.
Oncogene37(8)1075-1085(2018 02)
Qi M,Jiao M,Li X,Hu J,Wang L,Zou Y,Zhao M,Zhang R,Liu H,Mi J,Zhang L,Liu L,Gong Y,Han B

A cullin 4B-RING E3 ligase complex fine-tunes pancreatic δ cell paracrine interactions.
The Journal of clinical investigation127(7)2631-2646(2017 Jun)
Li Q,Cui M,Yang F,Li N,Jiang B,Yu Z,Zhang D,Wang Y,Zhu X,Hu H,Li PS,Ning SL,Wang S,Qi H,Song H,He D,Lin A,Zhang J,Liu F,Zhao J,Gao L,Yi F,Xue T,Sun JP,Gong Y,Yu X

REQUEST A QUOTE

EMAIL

gene@genscript.com

PHONE

1-877-436-7274

ONLINE FORM

Online Quote Submission

ONLINE FORM

Online Quote Submission

Cul4b cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

News & Blogs

REQUEST A QUOTE

EMAIL

PHONE

ONLINE FORM

ONLINE FORM