Atp2a2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Atp2a2
Entrez Gene ID	29693
Full Name	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
Synonyms	Serca2,SercaII
General protein information	Preferred Names ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 Names sarcoplasmic/endoplasmic reticulum calcium ATPase 2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 ATPase, Ca++ transporting, slow twitch 2 SR Ca(2+)-ATPase 2 calcium pump 2 calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform endoplasmic reticulum class 1/2 Ca(2+) ATPase sarco(endo)plasmic reticulum Ca(2+)-dependent ATPase 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 12 Map Location: 12q16
Summary	sarco(endo)plasmic reticulum Ca(2+) ATPase; involved in calcium transport and cycling in the heart and in calcium sequestering in enamel forming cells [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001110139.2	NP_001103609.1	sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform a
NM_001110823.2	NP_001104293.1	sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform b

Pathways from BioSystems

Homologies

Bos taurus (cattle)	ATP2A2	NP_001178359.1
Rattus norvegicus (Norway rat)	Atp2a2	NP_001104293.1
Mus musculus (house mouse)	Atp2a2	NP_001103610.1
Pan troglodytes (chimpanzee)	ATP2A2	XP_001141455.1
Gallus gallus (chicken)	ATP2A2	NP_001258903.1
Xenopus tropicalis (tropical clawed frog)	atp2a2	XP_004910568.1
Homo sapiens (human)	ATP2A2	NP_733765.1
Canis lupus familiaris (dog)	ATP2A2	NP_001003214.1
Danio rerio (zebrafish)	atp2a2a	NP_957259.1

Gene Ontology
Bibliography

Related articles in PubMed

The Cardiotoxicity Induced by Arsenic Trioxide is Alleviated by Salvianolic Acid A via Maintaining Calcium Homeostasis and Inhibiting Endoplasmic Reticulum Stress.
Wang R, Zhang J, Wang S, Wang M, Ye T, Du Y, Xie X, Ye J, Sun G, Sun X
Molecules (Basel, Switzerland)24(3)(2019 Feb)

Pharmacological inhibition of DNA methylation attenuates pressure overload-induced cardiac hypertrophy in rats.
Stenzig J, Schneeberger Y, Löser A, Peters BS, Schaefer A, Zhao RR, Ng SL, Höppner G, Geertz B, Hirt MN, Tan W, Wong E, Reichenspurner H, Foo RS, Eschenhagen T
Journal of molecular and cellular cardiology12053-63(2018 07)

THE M-RNA, EXPRESSION OF SERCA2 AND NCX1 IN THE PROCESS OF PHARMACOLOGICAL CELL PROTECTION IN EXPERIMENTAL ACUTE PANCREATITIS INDUCED BY TAUROCHOLATE.
Vasques ER, Cunha JEM, Kubrusly MS, Coelho AM, Sanpietri SN, Nader HB, Tersariol ILS, Lima MA, Chaib E, D'Albuquerque LAC
Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery31(1)e1352(2018 Jun)

The CCAAT box in the proximal SERCA2 gene promoter regulates basal and stress-induced transcription in cardiomyocytes.
Fragoso-Medina J, Rodriguez G, Zarain-Herzberg A
Molecular and cellular biochemistry442(1-2)19-28(2018 May)

Cardioprotective Effects of Serca2a Overexpression Against Ischemiareperfusion- induced Injuries in Rats.
Jiang Y, Tian LL, Wang LH, Zhao XD, Chen JW, Murao K, Zhu W, Dong L, Wang GQ, Sun WP, Zhang GX
Current gene therapy17(3)248-258(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Atp2a2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Atp2a2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa00765	NM_001110139.2 Latest version!	Rattus norvegicus ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 (Atp2a2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00
ORa00857	NM_001110823.2 Latest version!	Rattus norvegicus ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 (Atp2a2), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$559.30 $799.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Atp2a2 ( NM_001110139.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001103609.1 Rattus norvegicus ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 (Atp2a2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	ORa00765
Clone ID Related Accession (Same CDS sequence)	NM_001110139.2
Accession Version	NM_001110139.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2994bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1573660800000
Organism	Rattus norvegicus(Norway rat)
Product	sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform a
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC104314.8, J04022.1, CK356454.1, J04024.1, EV765256.1, J04023.1 and CK356436.1. On Nov 24, 2007 this sequence version replaced NM_001110139.1. Transcript Variant: This variant (2) differs in the 3' UTR and coding region compared to variant 3. The resulting isoform (a), also known as SERCA2A, has a shorter and distinct C-terminus compared to isoform b. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: J04023.1, X15635.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGAACG CTCACACAAA GACCGTGGAG GAGGTGCTGG GCCACTTCGG CGTCAACGAG 
AGCACGGGGC TGAGCCTGGA GCAGGTCAAG AAGCTCAAGG AGAGATGGGG CTCCAACGAA 
TTGCCGGCTG AAGAAGGAAA GACCTTGCTG GAACTTGTGA TCGAGCAGTT TGAAGACTTA 
CTAGTTAGAA TTTTATTGCT GGCAGCATGT ATATCTTTCG TTTTGGCTTG GTTCGAAGAA 
GGTGAAGAAA CGATTACAGC CTTTGTAGAA CCTTTTGTAA TTCTGCTTAT ATTGGTAGCC 
AATGCAATTG TGGGTGTATG GCAGGAGAGA AACGCTGAAA ATGCAATAGA AGCTCTTAAG 
GAGTATGAAC CTGAAATGGG CAAGGTGTAT CGACAGGACA GAAAGAGTGT GCAGCGGATT 
AAAGCGAAAG ATATAGTTCC TGGGGATATA GTGGAAATTG CTGTTGGTGA CAAAGTTCCG 
GCTGACATTA GATTGACATC CATCAAGTCT ACAACTCTGA GAGTTGACCA GTCGATTCTT 
ACAGGTGAAT CTGTCTCGGT CATCAAGCAT ACTGACCCTG TCCCTGACCC ACGAGCTGTT 
AATCAAGACA AAAAGAACAT GCTCTTTTCT GGCACAAACA TCGCTGCTGG CAAAGCTATG 
GGAGTGGTGG TGGCGACTGG AGTCAATACT GAGATCGGCA AGATCCGGGA TGAAATGGTT 
GCAACAGAAC AGGAGAGAAC ACCCCTACAG CAGAAGCTGG ACGAGTTTGG GGAACAGCTT 
TCCAAAGTTA TCTCCCTCAT TTGCATTGCA GTCTGGATCA TCAACATCGG GCATTTCAAT 
GACCCAGTTC ATGGTGGCTC TTGGATCAGA GGTGCCATCT ACTACTTTAA GATTGCAGTG 
GCCCTGGCTG TTGCTGCCAT CCCTGAGGGT CTGCCTGCTG TCATCACCAC CTGCTTGGCT 
CTTGGAACTC GAAGGATGGC AAAGAAAAAT GCTATTGTTC GAAGTCTGCC TTCTGTGGAA 
ACCCTTGGTT GTACTTCTGT TATCTGCTCA GACAAGACCG GCACACTTAC CACAAACCAG 
ATGTCCGTCT GCAGGATGTT CATTCTGGAC AAAGTAGAAG GTGATACTTG TTCCCTTAAT 
GAGTTTACCA TAACTGGATC AACCTATGCA CCCATTGGAG AAGTGCAAAA AGATGACAAG 
CCAGTGAAAT GCCATCAGTA TGACGGGCTT GTAGAGTTAG CAACGATCTG TGCTCTGTGT 
AATGACTCTG CTTTGGATTA CAATGAGGCG AAGGGTGTGT ATGAAAAAGT TGGAGAAGCC 
ACAGAGACTG CTCTCACGTG CCTGGTAGAG AAGATGAATG TATTCGACAC GGAGCTGAAG 
GGACTTTCTA AAATAGAACG CGCCAACGCC TGCAACTCGG TCATAAAACA GCTCATGAAG 
AAGGAATTCA CGCTAGAGTT TTCACGTGAT AGAAAATCAA TGTCCGTCTA CTGTACACCA 
AACAAACCGA GCCGGACGTC CATGAGCAAG ATGTTTGTGA AGGGTGCTCC AGAAGGTGTC 
ATCGACAGGT GCACCCACAT CCGAGTTGGA AGTACCAAGG TCCCCATGAC GCCTGGTGTT 
AAACAGAAGA TTATGTCTGT CATTCGGGAG TGGGGCAGTG GCAGCGACAC ACTGCGGTGC 
CTGGCTCTGG CCACTCATGA CAACCCGCTG AGGAGAGAGG AGATGCACCT GGAAGATTCT 
GCGAACTTCA TCAAATATGA GACCAATCTG ACTTTCGTTG GCTGTGTGGG CATGCTGGAC 
CCTCCCAGGA TTGAAGTGGC CTCTTCTGTG AAGCTGTGCC GGCAAGCGGG CATCCGAGTC 
ATCATGATCA CTGGGGATAA CAAAGGCACT GCTGTGGCCA TCTGTCGCCG CATTGGCATC 
TTTGGGCAGG ATGAGGATGT GACATCAAAG GCTTTTACAG GGCGAGAATT TGATGAATTA 
AGCCCCTCAG CCCAGAGAGA CGCCTGCTTA AATGCCCGTT GTTTTGCTCG AGTTGAACCT 
TCCCACAAGT CTAAGATCGT TGAGTTCCTG CAGTCCTTTG ATGAGATCAC AGCTATGACT 
GGTGATGGTG TGAACGACGC GCCCGCTCTG AAGAAGTCGG AAATCGGGAT TGCCATGGGC 
TCAGGGACTG CAGTGGCTAA GACGGCCTCT GAGATGGTGC TGGCCGACGA CAACTTCTCC 
ACCATCGTGG CCGCTGTTGA GGAGGGGCGC GCCATCTACA ACAACATGAA GCAGTTCATC 
CGCTACCTCA TCTCCTCCAA CGTGGGGGAG GTGGTCTGTA TCTTCCTGAC GGCAGCCCTT 
GGGTTTCCTG AAGCTTTGAT TCCTGTCCAG TTACTCTGGG TCAATCTGGT GACGGATGGT 
CTGCCTGCCA CTGCGCTGGG GTTCAATCCT CCAGATCTGG ACATCATGAA CAAACCCCCA 
CGGAACCCAA AAGAACCGCT GATCAGCGGG TGGCTCTTTT TCCGTTACCT GGCTATTGGC 
TGTTATGTTG GCGCTGCCAC CGTGGGTGCT GCTGCGTGGT GGTTCATCGC TGCTGACGGT 
GGTCCGAGAG TCTCCTTCTA CCAGCTGAGT CATTTCCTGC AGTGTAAGGA GGACAACCCA 
GACTTCGAAG GAGTGGATTG TGCAATCTTT GAGTCCCCGT ATCCGATGAC AATGGCACTT 
TCTGTTCTAG TCACCATAGA GATGTGCAAT GCCCTCAACA GCTTGTCTGA AAACCAGTCC 
CTGCTGAGGA TGCCCCCCTG GGAGAACATC TGGCTCGTGG GCTCCATCTG CTTGTCCATG 
TCCCTTCACT TCTTGATCCT CTACGTGGAA CCTTTGCCAC TCATTTTCCA GATCACACCG 
CTGAATCTGA CCCAGTGGCT GATGGTGCTG AAAATCTCCC TGCCTGTGAT CCTCATGGAC 
GAGACGCTCA AGTTTGTGGC CCGAAACTAC CTGGAGCCTG CAATACTGGA GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001103609.1
CDS	507..3500
Translation	MENAHTKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNELPAEEGKTLLELVIEQFEDLLVRILLLAACISFVLAWFEEGEETITAFVEPFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIVEIAVGDKVPADIRLTSIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPLQQKLDEFGEQLSKVISLICIAVWIINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILDKVEGDTCSLNEFTITGSTYAPIGEVQKDDKPVKCHQYDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKGAPEGVIDRCTHIRVGSTKVPMTPGVKQKIMSVIREWGSGSDTLRCLALATHDNPLRREEMHLEDSANFIKYETNLTFVGCVGMLDPPRIEVASSVKLCRQAGIRVIMITGDNKGTAVAICRRIGIFGQDEDVTSKAFTGREFDELSPSAQRDACLNARCFARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKSEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMNKPPRNPKEPLISGWLFFRYLAIGCYVGAATVGAAAWWFIAADGGPRVSFYQLSHFLQCKEDNPDFEGVDCAIFESPYPMTMALSVLVTIEMCNALNSLSENQSLLRMPPWENIWLVGSICLSMSLHFLILYVEPLPLIFQITPLNLTQWLMVLKISLPVILMDETLKFVARNYLEPAILE

Target ORF information:

RefSeq Version	NM_001110139.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 (Atp2a2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001110139.2

ORF Insert Sequence:

ATGGAGAACG CTCACACAAA GACCGTGGAG GAGGTGCTGG GCCACTTCGG CGTCAACGAG 
AGCACGGGGC TGAGCCTGGA GCAGGTCAAG AAGCTCAAGG AGAGATGGGG CTCCAACGAA 
TTGCCGGCTG AAGAAGGAAA GACCTTGCTG GAACTTGTGA TCGAGCAGTT TGAAGACTTA 
CTAGTTAGAA TTTTATTGCT GGCAGCATGT ATATCTTTCG TTTTGGCTTG GTTCGAAGAA 
GGTGAAGAAA CGATTACAGC CTTTGTAGAA CCTTTTGTAA TTCTGCTTAT ATTGGTAGCC 
AATGCAATTG TGGGTGTATG GCAGGAGAGA AACGCTGAAA ATGCAATAGA AGCTCTTAAG 
GAGTATGAAC CTGAAATGGG CAAGGTGTAT CGACAGGACA GAAAGAGTGT GCAGCGGATT 
AAAGCGAAAG ATATAGTTCC TGGGGATATA GTGGAAATTG CTGTTGGTGA CAAAGTTCCG 
GCTGACATTA GATTGACATC CATCAAGTCT ACAACTCTGA GAGTTGACCA GTCGATTCTT 
ACAGGTGAAT CTGTCTCGGT CATCAAGCAT ACTGACCCTG TCCCTGACCC ACGAGCTGTT 
AATCAAGACA AAAAGAACAT GCTCTTTTCT GGCACAAACA TCGCTGCTGG CAAAGCTATG 
GGAGTGGTGG TGGCGACTGG AGTCAATACT GAGATCGGCA AGATCCGGGA TGAAATGGTT 
GCAACAGAAC AGGAGAGAAC ACCCCTACAG CAGAAGCTGG ACGAGTTTGG GGAACAGCTT 
TCCAAAGTTA TCTCCCTCAT TTGCATTGCA GTCTGGATCA TCAACATCGG GCATTTCAAT 
GACCCAGTTC ATGGTGGCTC TTGGATCAGA GGTGCCATCT ACTACTTTAA GATTGCAGTG 
GCCCTGGCTG TTGCTGCCAT CCCTGAGGGT CTGCCTGCTG TCATCACCAC CTGCTTGGCT 
CTTGGAACTC GAAGGATGGC AAAGAAAAAT GCTATTGTTC GAAGTCTGCC TTCTGTGGAA 
ACCCTTGGTT GTACTTCTGT TATCTGCTCA GACAAGACCG GCACACTTAC CACAAACCAG 
ATGTCCGTCT GCAGGATGTT CATTCTGGAC AAAGTAGAAG GTGATACTTG TTCCCTTAAT 
GAGTTTACCA TAACTGGATC AACCTATGCA CCCATTGGAG AAGTGCAAAA AGATGACAAG 
CCAGTGAAAT GCCATCAGTA TGACGGGCTT GTAGAGTTAG CAACGATCTG TGCTCTGTGT 
AATGACTCTG CTTTGGATTA CAATGAGGCG AAGGGTGTGT ATGAAAAAGT TGGAGAAGCC 
ACAGAGACTG CTCTCACGTG CCTGGTAGAG AAGATGAATG TATTCGACAC GGAGCTGAAG 
GGACTTTCTA AAATAGAACG CGCCAACGCC TGCAACTCGG TCATAAAACA GCTCATGAAG 
AAGGAATTCA CGCTAGAGTT TTCACGTGAT AGAAAATCAA TGTCCGTCTA CTGTACACCA 
AACAAACCGA GCCGGACGTC CATGAGCAAG ATGTTTGTGA AGGGTGCTCC AGAAGGTGTC 
ATCGACAGGT GCACCCACAT CCGAGTTGGA AGTACCAAGG TCCCCATGAC GCCTGGTGTT 
AAACAGAAGA TTATGTCTGT CATTCGGGAG TGGGGCAGTG GCAGCGACAC ACTGCGGTGC 
CTGGCTCTGG CCACTCATGA CAACCCGCTG AGGAGAGAGG AGATGCACCT GGAAGATTCT 
GCGAACTTCA TCAAATATGA GACCAATCTG ACTTTCGTTG GCTGTGTGGG CATGCTGGAC 
CCTCCCAGGA TTGAAGTGGC CTCTTCTGTG AAGCTGTGCC GGCAAGCGGG CATCCGAGTC 
ATCATGATCA CTGGGGATAA CAAAGGCACT GCTGTGGCCA TCTGTCGCCG CATTGGCATC 
TTTGGGCAGG ATGAGGATGT GACATCAAAG GCTTTTACAG GGCGAGAATT TGATGAATTA 
AGCCCCTCAG CCCAGAGAGA CGCCTGCTTA AATGCCCGTT GTTTTGCTCG AGTTGAACCT 
TCCCACAAGT CTAAGATCGT TGAGTTCCTG CAGTCCTTTG ATGAGATCAC AGCTATGACT 
GGTGATGGTG TGAACGACGC GCCCGCTCTG AAGAAGTCGG AAATCGGGAT TGCCATGGGC 
TCAGGGACTG CAGTGGCTAA GACGGCCTCT GAGATGGTGC TGGCCGACGA CAACTTCTCC 
ACCATCGTGG CCGCTGTTGA GGAGGGGCGC GCCATCTACA ACAACATGAA GCAGTTCATC 
CGCTACCTCA TCTCCTCCAA CGTGGGGGAG GTGGTCTGTA TCTTCCTGAC GGCAGCCCTT 
GGGTTTCCTG AAGCTTTGAT TCCTGTCCAG TTACTCTGGG TCAATCTGGT GACGGATGGT 
CTGCCTGCCA CTGCGCTGGG GTTCAATCCT CCAGATCTGG ACATCATGAA CAAACCCCCA 
CGGAACCCAA AAGAACCGCT GATCAGCGGG TGGCTCTTTT TCCGTTACCT GGCTATTGGC 
TGTTATGTTG GCGCTGCCAC CGTGGGTGCT GCTGCGTGGT GGTTCATCGC TGCTGACGGT 
GGTCCGAGAG TCTCCTTCTA CCAGCTGAGT CATTTCCTGC AGTGTAAGGA GGACAACCCA 
GACTTCGAAG GAGTGGATTG TGCAATCTTT GAGTCCCCGT ATCCGATGAC AATGGCACTT 
TCTGTTCTAG TCACCATAGA GATGTGCAAT GCCCTCAACA GCTTGTCTGA AAACCAGTCC 
CTGCTGAGGA TGCCCCCCTG GGAGAACATC TGGCTCGTGG GCTCCATCTG CTTGTCCATG 
TCCCTTCACT TCTTGATCCT CTACGTGGAA CCTTTGCCAC TCATTTTCCA GATCACACCG 
CTGAATCTGA CCCAGTGGCT GATGGTGCTG AAAATCTCCC TGCCTGTGAT CCTCATGGAC 
GAGACGCTCA AGTTTGTGGC CCGAAACTAC CTGGAGCCTG CAATACTGGA GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Atp2a2 ( NM_001110823.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001104293.1 Rattus norvegicus ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 (Atp2a2), transcript variant 3, mRNA.

Price & Availability↑

CloneID	ORa00857
Clone ID Related Accession (Same CDS sequence)	NM_001110823.2
Accession Version	NM_001110823.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3132bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1573660800000
Organism	Rattus norvegicus(Norway rat)
Product	sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform b
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from J04022.1, BE119640.1, J04024.1, CK356454.1, CK358684.1 and AA900747.1. On Jun 20, 2009 this sequence version replaced NM_001110823.1. Transcript Variant: This variant (3) encodes the longer isoform (b), also known as SERCA2B. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: J04024.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGAGAACG CTCACACAAA GACCGTGGAG GAGGTGCTGG GCCACTTCGG CGTCAACGAG 
AGCACGGGGC TGAGCCTGGA GCAGGTCAAG AAGCTCAAGG AGAGATGGGG CTCCAACGAA 
TTGCCGGCTG AAGAAGGAAA GACCTTGCTG GAACTTGTGA TCGAGCAGTT TGAAGACTTA 
CTAGTTAGAA TTTTATTGCT GGCAGCATGT ATATCTTTCG TTTTGGCTTG GTTCGAAGAA 
GGTGAAGAAA CGATTACAGC CTTTGTAGAA CCTTTTGTAA TTCTGCTTAT ATTGGTAGCC 
AATGCAATTG TGGGTGTATG GCAGGAGAGA AACGCTGAAA ATGCAATAGA AGCTCTTAAG 
GAGTATGAAC CTGAAATGGG CAAGGTGTAT CGACAGGACA GAAAGAGTGT GCAGCGGATT 
AAAGCGAAAG ATATAGTTCC TGGGGATATA GTGGAAATTG CTGTTGGTGA CAAAGTTCCG 
GCTGACATTA GATTGACATC CATCAAGTCT ACAACTCTGA GAGTTGACCA GTCGATTCTT 
ACAGGTGAAT CTGTCTCGGT CATCAAGCAT ACTGACCCTG TCCCTGACCC ACGAGCTGTT 
AATCAAGACA AAAAGAACAT GCTCTTTTCT GGCACAAACA TCGCTGCTGG CAAAGCTATG 
GGAGTGGTGG TGGCGACTGG AGTCAATACT GAGATCGGCA AGATCCGGGA TGAAATGGTT 
GCAACAGAAC AGGAGAGAAC ACCCCTACAG CAGAAGCTGG ACGAGTTTGG GGAACAGCTT 
TCCAAAGTTA TCTCCCTCAT TTGCATTGCA GTCTGGATCA TCAACATCGG GCATTTCAAT 
GACCCAGTTC ATGGTGGCTC TTGGATCAGA GGTGCCATCT ACTACTTTAA GATTGCAGTG 
GCCCTGGCTG TTGCTGCCAT CCCTGAGGGT CTGCCTGCTG TCATCACCAC CTGCTTGGCT 
CTTGGAACTC GAAGGATGGC AAAGAAAAAT GCTATTGTTC GAAGTCTGCC TTCTGTGGAA 
ACCCTTGGTT GTACTTCTGT TATCTGCTCA GACAAGACCG GCACACTTAC CACAAACCAG 
ATGTCCGTCT GCAGGATGTT CATTCTGGAC AAAGTAGAAG GTGATACTTG TTCCCTTAAT 
GAGTTTACCA TAACTGGATC AACCTATGCA CCCATTGGAG AAGTGCAAAA AGATGACAAG 
CCAGTGAAAT GCCATCAGTA TGACGGGCTT GTAGAGTTAG CAACGATCTG TGCTCTGTGT 
AATGACTCTG CTTTGGATTA CAATGAGGCG AAGGGTGTGT ATGAAAAAGT TGGAGAAGCC 
ACAGAGACTG CTCTCACGTG CCTGGTAGAG AAGATGAATG TATTCGACAC GGAGCTGAAG 
GGACTTTCTA AAATAGAACG CGCCAACGCC TGCAACTCGG TCATAAAACA GCTCATGAAG 
AAGGAATTCA CGCTAGAGTT TTCACGTGAT AGAAAATCAA TGTCCGTCTA CTGTACACCA 
AACAAACCGA GCCGGACGTC CATGAGCAAG ATGTTTGTGA AGGGTGCTCC AGAAGGTGTC 
ATCGACAGGT GCACCCACAT CCGAGTTGGA AGTACCAAGG TCCCCATGAC GCCTGGTGTT 
AAACAGAAGA TTATGTCTGT CATTCGGGAG TGGGGCAGTG GCAGCGACAC ACTGCGGTGC 
CTGGCTCTGG CCACTCATGA CAACCCGCTG AGGAGAGAGG AGATGCACCT GGAAGATTCT 
GCGAACTTCA TCAAATATGA GACCAATCTG ACTTTCGTTG GCTGTGTGGG CATGCTGGAC 
CCTCCCAGGA TTGAAGTGGC CTCTTCTGTG AAGCTGTGCC GGCAAGCGGG CATCCGAGTC 
ATCATGATCA CTGGGGATAA CAAAGGCACT GCTGTGGCCA TCTGTCGCCG CATTGGCATC 
TTTGGGCAGG ATGAGGATGT GACATCAAAG GCTTTTACAG GGCGAGAATT TGATGAATTA 
AGCCCCTCAG CCCAGAGAGA CGCCTGCTTA AATGCCCGTT GTTTTGCTCG AGTTGAACCT 
TCCCACAAGT CTAAGATCGT TGAGTTCCTG CAGTCCTTTG ATGAGATCAC AGCTATGACT 
GGTGATGGTG TGAACGACGC GCCCGCTCTG AAGAAGTCGG AAATCGGGAT TGCCATGGGC 
TCAGGGACTG CAGTGGCTAA GACGGCCTCT GAGATGGTGC TGGCCGACGA CAACTTCTCC 
ACCATCGTGG CCGCTGTTGA GGAGGGGCGC GCCATCTACA ACAACATGAA GCAGTTCATC 
CGCTACCTCA TCTCCTCCAA CGTGGGGGAG GTGGTCTGTA TCTTCCTGAC GGCAGCCCTT 
GGGTTTCCTG AAGCTTTGAT TCCTGTCCAG TTACTCTGGG TCAATCTGGT GACGGATGGT 
CTGCCTGCCA CTGCGCTGGG GTTCAATCCT CCAGATCTGG ACATCATGAA CAAACCCCCA 
CGGAACCCAA AAGAACCGCT GATCAGCGGG TGGCTCTTTT TCCGTTACCT GGCTATTGGC 
TGTTATGTTG GCGCTGCCAC CGTGGGTGCT GCTGCGTGGT GGTTCATCGC TGCTGACGGT 
GGTCCGAGAG TCTCCTTCTA CCAGCTGAGT CATTTCCTGC AGTGTAAGGA GGACAACCCA 
GACTTCGAAG GAGTGGATTG TGCAATCTTT GAGTCCCCGT ATCCGATGAC AATGGCACTT 
TCTGTTCTAG TCACCATAGA GATGTGCAAT GCCCTCAACA GCTTGTCTGA AAACCAGTCC 
CTGCTGAGGA TGCCCCCCTG GGAGAACATC TGGCTCGTGG GCTCCATCTG CTTGTCCATG 
TCCCTTCACT TCTTGATCCT CTACGTGGAA CCTTTGCCAC TCATTTTCCA GATCACACCG 
CTGAATCTGA CCCAGTGGCT GATGGTGCTG AAAATCTCCC TGCCTGTGAT CCTCATGGAC 
GAGACGCTCA AGTTTGTGGC CCGAAACTAC CTGGAGCCTG GTAAAGAGTG TGCGCAGCCT 
GCCACCAAAC CCTCCTGCTC CCTGTCGGCA TGCACCGACG GCATTTCCTG GCCCTTTGTG 
CTGCTCATTA TGCCCCTGGT GGTCTGGGTC TACAGCACAG ACACTAACTT TAGTGATATG 
TTCTGGTCTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001104293.1
CDS	507..3638
Translation	MENAHTKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNELPAEEGKTLLELVIEQFEDLLVRILLLAACISFVLAWFEEGEETITAFVEPFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIVEIAVGDKVPADIRLTSIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPLQQKLDEFGEQLSKVISLICIAVWIINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILDKVEGDTCSLNEFTITGSTYAPIGEVQKDDKPVKCHQYDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKGAPEGVIDRCTHIRVGSTKVPMTPGVKQKIMSVIREWGSGSDTLRCLALATHDNPLRREEMHLEDSANFIKYETNLTFVGCVGMLDPPRIEVASSVKLCRQAGIRVIMITGDNKGTAVAICRRIGIFGQDEDVTSKAFTGREFDELSPSAQRDACLNARCFARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKSEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMNKPPRNPKEPLISGWLFFRYLAIGCYVGAATVGAAAWWFIAADGGPRVSFYQLSHFLQCKEDNPDFEGVDCAIFESPYPMTMALSVLVTIEMCNALNSLSENQSLLRMPPWENIWLVGSICLSMSLHFLILYVEPLPLIFQITPLNLTQWLMVLKISLPVILMDETLKFVARNYLEPGKECAQPATKPSCSLSACTDGISWPFVLLIMPLVVWVYSTDTNFSDMFWS

Target ORF information:

RefSeq Version	NM_001110823.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 (Atp2a2), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001110823.2

ORF Insert Sequence:

ATGGAGAACG CTCACACAAA GACCGTGGAG GAGGTGCTGG GCCACTTCGG CGTCAACGAG 
AGCACGGGGC TGAGCCTGGA GCAGGTCAAG AAGCTCAAGG AGAGATGGGG CTCCAACGAA 
TTGCCGGCTG AAGAAGGAAA GACCTTGCTG GAACTTGTGA TCGAGCAGTT TGAAGACTTA 
CTAGTTAGAA TTTTATTGCT GGCAGCATGT ATATCTTTCG TTTTGGCTTG GTTCGAAGAA 
GGTGAAGAAA CGATTACAGC CTTTGTAGAA CCTTTTGTAA TTCTGCTTAT ATTGGTAGCC 
AATGCAATTG TGGGTGTATG GCAGGAGAGA AACGCTGAAA ATGCAATAGA AGCTCTTAAG 
GAGTATGAAC CTGAAATGGG CAAGGTGTAT CGACAGGACA GAAAGAGTGT GCAGCGGATT 
AAAGCGAAAG ATATAGTTCC TGGGGATATA GTGGAAATTG CTGTTGGTGA CAAAGTTCCG 
GCTGACATTA GATTGACATC CATCAAGTCT ACAACTCTGA GAGTTGACCA GTCGATTCTT 
ACAGGTGAAT CTGTCTCGGT CATCAAGCAT ACTGACCCTG TCCCTGACCC ACGAGCTGTT 
AATCAAGACA AAAAGAACAT GCTCTTTTCT GGCACAAACA TCGCTGCTGG CAAAGCTATG 
GGAGTGGTGG TGGCGACTGG AGTCAATACT GAGATCGGCA AGATCCGGGA TGAAATGGTT 
GCAACAGAAC AGGAGAGAAC ACCCCTACAG CAGAAGCTGG ACGAGTTTGG GGAACAGCTT 
TCCAAAGTTA TCTCCCTCAT TTGCATTGCA GTCTGGATCA TCAACATCGG GCATTTCAAT 
GACCCAGTTC ATGGTGGCTC TTGGATCAGA GGTGCCATCT ACTACTTTAA GATTGCAGTG 
GCCCTGGCTG TTGCTGCCAT CCCTGAGGGT CTGCCTGCTG TCATCACCAC CTGCTTGGCT 
CTTGGAACTC GAAGGATGGC AAAGAAAAAT GCTATTGTTC GAAGTCTGCC TTCTGTGGAA 
ACCCTTGGTT GTACTTCTGT TATCTGCTCA GACAAGACCG GCACACTTAC CACAAACCAG 
ATGTCCGTCT GCAGGATGTT CATTCTGGAC AAAGTAGAAG GTGATACTTG TTCCCTTAAT 
GAGTTTACCA TAACTGGATC AACCTATGCA CCCATTGGAG AAGTGCAAAA AGATGACAAG 
CCAGTGAAAT GCCATCAGTA TGACGGGCTT GTAGAGTTAG CAACGATCTG TGCTCTGTGT 
AATGACTCTG CTTTGGATTA CAATGAGGCG AAGGGTGTGT ATGAAAAAGT TGGAGAAGCC 
ACAGAGACTG CTCTCACGTG CCTGGTAGAG AAGATGAATG TATTCGACAC GGAGCTGAAG 
GGACTTTCTA AAATAGAACG CGCCAACGCC TGCAACTCGG TCATAAAACA GCTCATGAAG 
AAGGAATTCA CGCTAGAGTT TTCACGTGAT AGAAAATCAA TGTCCGTCTA CTGTACACCA 
AACAAACCGA GCCGGACGTC CATGAGCAAG ATGTTTGTGA AGGGTGCTCC AGAAGGTGTC 
ATCGACAGGT GCACCCACAT CCGAGTTGGA AGTACCAAGG TCCCCATGAC GCCTGGTGTT 
AAACAGAAGA TTATGTCTGT CATTCGGGAG TGGGGCAGTG GCAGCGACAC ACTGCGGTGC 
CTGGCTCTGG CCACTCATGA CAACCCGCTG AGGAGAGAGG AGATGCACCT GGAAGATTCT 
GCGAACTTCA TCAAATATGA GACCAATCTG ACTTTCGTTG GCTGTGTGGG CATGCTGGAC 
CCTCCCAGGA TTGAAGTGGC CTCTTCTGTG AAGCTGTGCC GGCAAGCGGG CATCCGAGTC 
ATCATGATCA CTGGGGATAA CAAAGGCACT GCTGTGGCCA TCTGTCGCCG CATTGGCATC 
TTTGGGCAGG ATGAGGATGT GACATCAAAG GCTTTTACAG GGCGAGAATT TGATGAATTA 
AGCCCCTCAG CCCAGAGAGA CGCCTGCTTA AATGCCCGTT GTTTTGCTCG AGTTGAACCT 
TCCCACAAGT CTAAGATCGT TGAGTTCCTG CAGTCCTTTG ATGAGATCAC AGCTATGACT 
GGTGATGGTG TGAACGACGC GCCCGCTCTG AAGAAGTCGG AAATCGGGAT TGCCATGGGC 
TCAGGGACTG CAGTGGCTAA GACGGCCTCT GAGATGGTGC TGGCCGACGA CAACTTCTCC 
ACCATCGTGG CCGCTGTTGA GGAGGGGCGC GCCATCTACA ACAACATGAA GCAGTTCATC 
CGCTACCTCA TCTCCTCCAA CGTGGGGGAG GTGGTCTGTA TCTTCCTGAC GGCAGCCCTT 
GGGTTTCCTG AAGCTTTGAT TCCTGTCCAG TTACTCTGGG TCAATCTGGT GACGGATGGT 
CTGCCTGCCA CTGCGCTGGG GTTCAATCCT CCAGATCTGG ACATCATGAA CAAACCCCCA 
CGGAACCCAA AAGAACCGCT GATCAGCGGG TGGCTCTTTT TCCGTTACCT GGCTATTGGC 
TGTTATGTTG GCGCTGCCAC CGTGGGTGCT GCTGCGTGGT GGTTCATCGC TGCTGACGGT 
GGTCCGAGAG TCTCCTTCTA CCAGCTGAGT CATTTCCTGC AGTGTAAGGA GGACAACCCA 
GACTTCGAAG GAGTGGATTG TGCAATCTTT GAGTCCCCGT ATCCGATGAC AATGGCACTT 
TCTGTTCTAG TCACCATAGA GATGTGCAAT GCCCTCAACA GCTTGTCTGA AAACCAGTCC 
CTGCTGAGGA TGCCCCCCTG GGAGAACATC TGGCTCGTGG GCTCCATCTG CTTGTCCATG 
TCCCTTCACT TCTTGATCCT CTACGTGGAA CCTTTGCCAC TCATTTTCCA GATCACACCG 
CTGAATCTGA CCCAGTGGCT GATGGTGCTG AAAATCTCCC TGCCTGTGAT CCTCATGGAC 
GAGACGCTCA AGTTTGTGGC CCGAAACTAC CTGGAGCCTG GTAAAGAGTG TGCGCAGCCT 
GCCACCAAAC CCTCCTGCTC CCTGTCGGCA TGCACCGACG GCATTTCCTG GCCCTTTGTG 
CTGCTCATTA TGCCCCTGGT GGTCTGGGTC TACAGCACAG ACACTAACTT TAGTGATATG 
TTCTGGTCTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The Cardiotoxicity Induced by Arsenic Trioxide is Alleviated by Salvianolic Acid A via Maintaining Calcium Homeostasis and Inhibiting Endoplasmic Reticulum Stress.
Molecules (Basel, Switzerland)24(3)(2019 Feb)
Wang R,Zhang J,Wang S,Wang M,Ye T,Du Y,Xie X,Ye J,Sun G,Sun X

Pharmacological inhibition of DNA methylation attenuates pressure overload-induced cardiac hypertrophy in rats.
Journal of molecular and cellular cardiology12053-63(2018 07)
Stenzig J,Schneeberger Y,Löser A,Peters BS,Schaefer A,Zhao RR,Ng SL,Höppner G,Geertz B,Hirt MN,Tan W,Wong E,Reichenspurner H,Foo RS,Eschenhagen T

THE M-RNA, EXPRESSION OF SERCA2 AND NCX1 IN THE PROCESS OF PHARMACOLOGICAL CELL PROTECTION IN EXPERIMENTAL ACUTE PANCREATITIS INDUCED BY TAUROCHOLATE.
Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery31(1)e1352(2018 Jun)
Vasques ER,Cunha JEM,Kubrusly MS,Coelho AM,Sanpietri SN,Nader HB,Tersariol ILS,Lima MA,Chaib E,D'Albuquerque LAC

The CCAAT box in the proximal SERCA2 gene promoter regulates basal and stress-induced transcription in cardiomyocytes.
Molecular and cellular biochemistry442(1-2)19-28(2018 May)
Fragoso-Medina J,Rodriguez G,Zarain-Herzberg A

Cardioprotective Effects of Serca2a Overexpression Against Ischemiareperfusion- induced Injuries in Rats.
Current gene therapy17(3)248-258(2017)
Jiang Y,Tian LL,Wang LH,Zhao XD,Chen JW,Murao K,Zhu W,Dong L,Wang GQ,Sun WP,Zhang GX

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Atp2a2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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