| Gene Symbol | Fah |
| Entrez Gene ID | 29383 |
| Full Name | fumarylacetoacetate hydrolase |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Rattus norvegicus(Norway rat) |
| Genome | |
| Summary | deficiency leads to human hereditary tyrosinemia type 1 [RGD, Feb 2006]. |
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Fah cDNA ORF clone, Rattus norvegicus(Norway rat)
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Gene
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Clones
gRNAs
The following Fah gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fah cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID ORa03148 Clone ID Related Accession (Same CDS sequence) NM_017181.2 Accession Version NM_017181.2 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 1260bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1568995200000 Organism Rattus norvegicus(Norway rat) Product fumarylacetoacetase Comment Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC076381.1. On Jul 12, 2004 this sequence version replaced NM_017181.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC076381.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN01906352, SAMN01906353 [ECO:0000350] ##Evidence-Data-END##
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201ATGTCCTTTA TTCCGGTGGC CGAGGACTCC GACTTTCCCA TCCAAAACCT GCCCTATGGC
GTTTTCTCCA CTCAAAGCAA CCCAAAGCCA CGGATTGGTG TGGCCATCGG TGACCAGATC
TTGGACCTGA GTGTCATTAA ACACCTCTTT ACCGGACCTG TCCTCTCCAA ACATCAGCAT
GTCTTCGATG AGACAACTCT CAATAGCTTT ATGGGCCTCG GCCAAGCGGC ATGGAAGGAG
GCAAGAGCAT CCTTACAGAA CTTACTGTCT GCCAGCCAAG CCCAGCTCAG AGATGACAAG
GAGCTTCGGC AGCGTGCATT CACCTCCCAG GCTTCTGCCA CGATGCACCT TCCTGCTACC
ATAGGAGACT ACACGGACTT CTACTCCTCT CTGCAGCATG CCACTAACGT TGGCATTATG
TTCAGGGGCA AGGAGAATGC GCTGTTGCCC AATTGGCTCC ACTTACCTGT GGGATACCAT
GGCCGAGCTT CCTCCGTTGT GGTGTCTGGT ACCCCAATTC GAAGACCCAT GGGACAGATG
AGACCTGATA ACTCAAAGCC TCCTGTGTAT GGTGCCAGCA AACGCTTAGA CATGGAGTTG
GAAATGGCTT TCTTTGTAGG CCCTGGGAAC AGATTCGGCG AGCCAATCCC CATTTCCAAG
GCCCAGGAGC ACATTTTCGG GATGGTCCTC ATGAACGACT GGAGTGCTCG AGACATCCAG
CAATGGGAGT ACGTCCCCCT TGGGCCATTC CTGGGGAAAA GTTTTGGAAC CACCATCTCC
CCATGGGTGG TGCCCATGGA TGCTCTCATG CCCTTTGTGG TGCCAAACCC AAAGCAGGAC
CCTAAGCCCC TGCCATATCT CTGCCACAGC CAGCCCTACA CATTTGATAT CAACCTGTCC
GTTGCTTTGA AAGGAGAAGG AATGAGCCAG GCAGCTACCA TCTGCAGGTC CAACTTTAAG
CACATGTACT GGACCATTCT GCAGCAACTG ACACACCACT CTGTTAATGG ATGCAATCTG
AGACCTGGGG ACCTCTTGGC TTCTGGAACC ATCAGTGGAT CAGACCCTGA AAGCTTTGGC
TCCATGCTGG AACTGTCCTG GAAGGGAACA AAGGCTATCG ATGTGGGGCA GGGGCAAACC
AGGACCTTTC TTCTGGACGG AGATGAAGTC ATCATAACAG GTCACTGCCA GGGGGATGGC
TACCGTGTTG GTTTTGGCCA ATGTGCTGGG AAAGTGCTGC CTGCCCTCTC GCCAGCCTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_058877.1 CDS 101..1360 Translation 
Target ORF information:
RefSeq Version NM_017181.2 Organism Rattus norvegicus(Norway rat) Definition Rattus norvegicus fumarylacetoacetate hydrolase (Fah), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_017181.2
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201ATGTCCTTTA TTCCGGTGGC CGAGGACTCC GACTTTCCCA TCCAAAACCT GCCCTATGGC
GTTTTCTCCA CTCAAAGCAA CCCAAAGCCA CGGATTGGTG TGGCCATCGG TGACCAGATC
TTGGACCTGA GTGTCATTAA ACACCTCTTT ACCGGACCTG TCCTCTCCAA ACATCAGCAT
GTCTTCGATG AGACAACTCT CAATAGCTTT ATGGGCCTCG GCCAAGCGGC ATGGAAGGAG
GCAAGAGCAT CCTTACAGAA CTTACTGTCT GCCAGCCAAG CCCAGCTCAG AGATGACAAG
GAGCTTCGGC AGCGTGCATT CACCTCCCAG GCTTCTGCCA CGATGCACCT TCCTGCTACC
ATAGGAGACT ACACGGACTT CTACTCCTCT CTGCAGCATG CCACTAACGT TGGCATTATG
TTCAGGGGCA AGGAGAATGC GCTGTTGCCC AATTGGCTCC ACTTACCTGT GGGATACCAT
GGCCGAGCTT CCTCCGTTGT GGTGTCTGGT ACCCCAATTC GAAGACCCAT GGGACAGATG
AGACCTGATA ACTCAAAGCC TCCTGTGTAT GGTGCCAGCA AACGCTTAGA CATGGAGTTG
GAAATGGCTT TCTTTGTAGG CCCTGGGAAC AGATTCGGCG AGCCAATCCC CATTTCCAAG
GCCCAGGAGC ACATTTTCGG GATGGTCCTC ATGAACGACT GGAGTGCTCG AGACATCCAG
CAATGGGAGT ACGTCCCCCT TGGGCCATTC CTGGGGAAAA GTTTTGGAAC CACCATCTCC
CCATGGGTGG TGCCCATGGA TGCTCTCATG CCCTTTGTGG TGCCAAACCC AAAGCAGGAC
CCTAAGCCCC TGCCATATCT CTGCCACAGC CAGCCCTACA CATTTGATAT CAACCTGTCC
GTTGCTTTGA AAGGAGAAGG AATGAGCCAG GCAGCTACCA TCTGCAGGTC CAACTTTAAG
CACATGTACT GGACCATTCT GCAGCAACTG ACACACCACT CTGTTAATGG ATGCAATCTG
AGACCTGGGG ACCTCTTGGC TTCTGGAACC ATCAGTGGAT CAGACCCTGA AAGCTTTGGC
TCCATGCTGG AACTGTCCTG GAAGGGAACA AAGGCTATCG ATGTGGGGCA GGGGCAAACC
AGGACCTTTC TTCTGGACGG AGATGAAGTC ATCATAACAG GTCACTGCCA GGGGGATGGC
TACCGTGTTG GTTTTGGCCA ATGTGCTGGG AAAGTGCTGC CTGCCCTCTC GCCAGCCTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
Dendrimer-Based Lipid Nanoparticles Deliver Therapeutic FAH mRNA to Normalize Liver Function and Extend Survival in a Mouse Model of Hepatorenal Tyrosinemia Type I.
Advanced materials (Deerfield Beach, Fla.)30(52)e1805308(2018 Dec)
Cheng Q,Wei T,Jia Y,Farbiak L,Zhou K,Zhang S,Wei Y,Zhu H,Siegwart DJ
Cas9-nickase-mediated genome editing corrects hereditary tyrosinemia in rats.
The Journal of biological chemistry293(18)6883-6892(2018 05)
Shao Y,Wang L,Guo N,Wang S,Yang L,Li Y,Wang M,Yin S,Han H,Zeng L,Zhang L,Hui L,Ding Q,Zhang J,Geng H,Liu M,Li D
Silent Tyrosinemia Type I Without Elevated Tyrosine or Succinylacetone Associated with Liver Cirrhosis and Hepatocellular Carcinoma.
Human mutation37(10)1097-105(2016 10)
Blackburn PR,Hickey RD,Nace RA,Giama NH,Kraft DL,Bordner AJ,Chaiteerakij R,McCormick JB,Radulovic M,Graham RP,Torbenson MS,Tortorelli S,Scott CR,Lindor NM,Milliner DS,Oglesbee D,Al-Qabandi W,Grompe M,Gavrilov DK,El-Youssef M,Clark KJ,Atwal PS,Roberts LR,Klee EW,Ekker SC
Efficient liver repopulation of transplanted hepatocyte prevents cirrhosis in a rat model of hereditary tyrosinemia type I.
Scientific reports631460(2016 08)
Zhang L,Shao Y,Li L,Tian F,Cen J,Chen X,Hu D,Zhou Y,Xie W,Zheng Y,Ji Y,Liu M,Li D,Hui L
Sub-nephrotoxic cisplatin sensitizes rats to acute renal failure and increases urinary excretion of fumarylacetoacetase.
Toxicology letters234(2)99-109(2015 Apr)
Vicente-Vicente L,Sánchez-Juanes F,García-Sánchez O,Blanco-Gozalo V,Pescador M,Sevilla MA,González-Buitrago JM,López-Hernández FJ,López-Novoa JM,Morales AI
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