Fah cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fah
Entrez Gene ID	14085
Full Name	fumarylacetoacetate hydrolase
Synonyms	swst
General protein information	Preferred Names fumarylacetoacetate hydrolase Names fumarylacetoacetase FAA beta-diketonase
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7 D3\|7 48.36 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_010176.4	NP_034306.2	fumarylacetoacetase

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	fah	NP_955895.1
Drosophila melanogaster (fruit fly)	Faa	NP_524830.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005865	XP_315893.3
Rattus norvegicus (Norway rat)	Fah	NP_058877.1
Caenorhabditis elegans (roundworm)	fah-1	NP_509083.1
Arabidopsis thaliana (thale cress)	AT1G12050	NP_172669.2
Magnaporthe oryzae (rice blast fungus)	MGG_00317	XP_003718771.1
Pan troglodytes (chimpanzee)	FAH	XP_001155533.3
Mus musculus (house mouse)	Fah	NP_034306.2
Macaca mulatta (Rhesus monkey)	FAH	XP_001109382.1
Neurospora crassa	NCU05537	XP_960499.1
Canis lupus familiaris (dog)	FAH	XP_005618474.1
Xenopus tropicalis (tropical clawed frog)	fah	NP_001107523.1
Homo sapiens (human)	FAH	NP_000128.1
Bos taurus (cattle)	FAH	NP_001092382.1
Gallus gallus (chicken)	FAH	NP_001264402.1
Oryza sativa (rice)	Os02g0196800	NP_001046195.1

Gene Ontology
Bibliography

Related articles in PubMed

Inflammatory Cytokine TNFα Promotes the Long-Term Expansion of Primary Hepatocytes in 3D Culture.
Peng WC, Logan CY, Fish M, Anbarchian T, Aguisanda F, Álvarez-Varela A, Wu P, Jin Y, Zhu J, Li B, Grompe M, Wang B, Nusse R
Cell175(6)1607-1619.e15(2018 11)

Combinatorial genetics in liver repopulation and carcinogenesis with a in vivo CRISPR activation platform.
Wangensteen KJ, Wang YJ, Dou Z, Wang AW, Mosleh-Shirazi E, Horlbeck MA, Gilbert LA, Weissman JS, Berger SL, Kaestner KH
Hepatology (Baltimore, Md.)68(2)663-676(2018 08)

Mechanistic inferences from the crystal structure of fumarylacetoacetate hydrolase with a bound phosphorus-based inhibitor.
Bateman RL, Bhanumoorthy P, Witte JF, McClard RW, Grompe M, Timm DE
The Journal of biological chemistry276(18)15284-91(2001 May)

Point mutations in the murine fumarylacetoacetate hydrolase gene: Animal models for the human genetic disorder hereditary tyrosinemia type 1.
Aponte JL, Sega GA, Hauser LJ, Dhar MS, Withrow CM, Carpenter DA, Rinchik EM, Culiat CT, Johnson DK
Proceedings of the National Academy of Sciences of the United States of America98(2)641-5(2001 Jan)

Crystal structure and mechanism of a carbon-carbon bond hydrolase.
Timm DE, Mueller HA, Bhanumoorthy P, Harp JM, Bunick GJ
Structure (London, England : 1993)7(9)1023-33(1999 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Fah gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fah cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu18997	NM_010176.4 Latest version!	Mus musculus fumarylacetoacetate hydrolase (Fah), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fah ( NM_010176.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034306.2 Mus musculus fumarylacetoacetate hydrolase (Fah), mRNA.

Price & Availability↑

CloneID	OMu18997
Clone ID Related Accession (Same CDS sequence)	NM_010176.4
Accession Version	NM_010176.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1260bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577376000000
Organism	Mus musculus(house mouse)
Product	fumarylacetoacetase
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY265969.1, BY293890.1, AK158808.1 and AI848212.1. On Jun 18, 2009 this sequence version replaced NM_010176.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK158808.1, AK143759.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386, SAMN01164134 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCCTTTA TTCCAGTGGC CGAGGACTCC GACTTTCCCA TCCAAAACCT GCCCTATGGT 
GTTTTCTCCA CTCAAAGCAA CCCAAAGCCA CGGATTGGTG TAGCCATCGG TGACCAGATC 
TTGGACCTGA GTGTCATTAA ACACCTCTTT ACCGGACCTG CCCTTTCCAA ACATCAACAT 
GTCTTCGATG AGACAACTCT CAATAACTTC ATGGGTCTGG GTCAAGCTGC ATGGAAGGAG 
GCAAGAGCAT CCTTACAGAA CTTACTGTCT GCCAGCCAAG CCCGGCTCAG AGATGACAAG 
GAGCTTCGGC AGCGTGCATT CACCTCCCAG GCTTCTGCGA CAATGCACCT TCCTGCTACC 
ATAGGAGACT ACACGGACTT CTACTCTTCT CGGCAGCATG CCACCAATGT TGGCATTATG 
TTCAGAGGCA AGGAGAATGC GCTGTTGCCA AATTGGCTCC ACTTACCTGT GGGATACCAT 
GGCCGAGCTT CCTCCATTGT GGTATCTGGA ACCCCGATTC GAAGACCCAT GGGGCAGATG 
AGACCTGATA ACTCAAAGCC TCCTGTGTAT GGTGCCTGCA GACTCTTAGA CATGGAGTTG 
GAAATGGCTT TCTTCGTAGG CCCTGGGAAC AGATTCGGAG AGCCAATCCC CATTTCCAAA 
GCCCATGAAC ACATTTTCGG GATGGTCCTC ATGAACGACT GGAGCGCACG AGACATCCAG 
CAATGGGAGT ACGTCCCACT TGGGCCATTC CTGGGGAAAA GCTTTGGAAC CACAATCTCC 
CCGTGGGTGG TGCCTATGGA TGCCCTCATG CCCTTTGTGG TGCCAAACCC AAAGCAGGAC 
CCCAAGCCCT TGCCATATCT CTGCCACAGC CAGCCCTACA CATTTGATAT CAACCTGTCT 
GTCTCTTTGA AAGGAGAAGG AATGAGCCAG GCGGCTACCA TCTGCAGGTC TAACTTTAAG 
CACATGTACT GGACCATGCT GCAGCAACTC ACACACCACT CTGTTAATGG ATGCAACCTG 
AGACCTGGGG ACCTCTTGGC TTCTGGAACC ATCAGTGGAT CAGACCCTGA AAGCTTTGGC 
TCCATGCTGG AACTGTCCTG GAAGGGAACA AAGGCCATCG ATGTGGAGCA GGGGCAGACC 
AGGACCTTCC TGCTGGACGG CGATGAAGTC ATCATAACAG GTCACTGCCA GGGGGACGGC 
TACCGTGTTG GCTTTGGCCA GTGTGCTGGG AAAGTGCTGC CTGCCCTTTC ACCAGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034306.2
CDS	220..1479
Translation	MSFIPVAEDSDFPIQNLPYGVFSTQSNPKPRIGVAIGDQILDLSVIKHLFTGPALSKHQHVFDETTLNNFMGLGQAAWKEARASLQNLLSASQARLRDDKELRQRAFTSQASATMHLPATIGDYTDFYSSRQHATNVGIMFRGKENALLPNWLHLPVGYHGRASSIVVSGTPIRRPMGQMRPDNSKPPVYGACRLLDMELEMAFFVGPGNRFGEPIPISKAHEHIFGMVLMNDWSARDIQQWEYVPLGPFLGKSFGTTISPWVVPMDALMPFVVPNPKQDPKPLPYLCHSQPYTFDINLSVSLKGEGMSQAATICRSNFKHMYWTMLQQLTHHSVNGCNLRPGDLLASGTISGSDPESFGSMLELSWKGTKAIDVEQGQTRTFLLDGDEVIITGHCQGDGYRVGFGQCAGKVLPALSPA

Target ORF information:

RefSeq Version	NM_010176.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus fumarylacetoacetate hydrolase (Fah), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010176.4

ORF Insert Sequence:

ATGTCCTTTA TTCCAGTGGC CGAGGACTCC GACTTTCCCA TCCAAAACCT GCCCTATGGT 
GTTTTCTCCA CTCAAAGCAA CCCAAAGCCA CGGATTGGTG TAGCCATCGG TGACCAGATC 
TTGGACCTGA GTGTCATTAA ACACCTCTTT ACCGGACCTG CCCTTTCCAA ACATCAACAT 
GTCTTCGATG AGACAACTCT CAATAACTTC ATGGGTCTGG GTCAAGCTGC ATGGAAGGAG 
GCAAGAGCAT CCTTACAGAA CTTACTGTCT GCCAGCCAAG CCCGGCTCAG AGATGACAAG 
GAGCTTCGGC AGCGTGCATT CACCTCCCAG GCTTCTGCGA CAATGCACCT TCCTGCTACC 
ATAGGAGACT ACACGGACTT CTACTCTTCT CGGCAGCATG CCACCAATGT TGGCATTATG 
TTCAGAGGCA AGGAGAATGC GCTGTTGCCA AATTGGCTCC ACTTACCTGT GGGATACCAT 
GGCCGAGCTT CCTCCATTGT GGTATCTGGA ACCCCGATTC GAAGACCCAT GGGGCAGATG 
AGACCTGATA ACTCAAAGCC TCCTGTGTAT GGTGCCTGCA GACTCTTAGA CATGGAGTTG 
GAAATGGCTT TCTTCGTAGG CCCTGGGAAC AGATTCGGAG AGCCAATCCC CATTTCCAAA 
GCCCATGAAC ACATTTTCGG GATGGTCCTC ATGAACGACT GGAGCGCACG AGACATCCAG 
CAATGGGAGT ACGTCCCACT TGGGCCATTC CTGGGGAAAA GCTTTGGAAC CACAATCTCC 
CCGTGGGTGG TGCCTATGGA TGCCCTCATG CCCTTTGTGG TGCCAAACCC AAAGCAGGAC 
CCCAAGCCCT TGCCATATCT CTGCCACAGC CAGCCCTACA CATTTGATAT CAACCTGTCT 
GTCTCTTTGA AAGGAGAAGG AATGAGCCAG GCGGCTACCA TCTGCAGGTC TAACTTTAAG 
CACATGTACT GGACCATGCT GCAGCAACTC ACACACCACT CTGTTAATGG ATGCAACCTG 
AGACCTGGGG ACCTCTTGGC TTCTGGAACC ATCAGTGGAT CAGACCCTGA AAGCTTTGGC 
TCCATGCTGG AACTGTCCTG GAAGGGAACA AAGGCCATCG ATGTGGAGCA GGGGCAGACC 
AGGACCTTCC TGCTGGACGG CGATGAAGTC ATCATAACAG GTCACTGCCA GGGGGACGGC 
TACCGTGTTG GCTTTGGCCA GTGTGCTGGG AAAGTGCTGC CTGCCCTTTC ACCAGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Inflammatory Cytokine TNFα Promotes the Long-Term Expansion of Primary Hepatocytes in 3D Culture.
Cell175(6)1607-1619.e15(2018 11)
Peng WC,Logan CY,Fish M,Anbarchian T,Aguisanda F,Álvarez-Varela A,Wu P,Jin Y,Zhu J,Li B,Grompe M,Wang B,Nusse R

Combinatorial genetics in liver repopulation and carcinogenesis with a in vivo CRISPR activation platform.
Hepatology (Baltimore, Md.)68(2)663-676(2018 08)
Wangensteen KJ,Wang YJ,Dou Z,Wang AW,Mosleh-Shirazi E,Horlbeck MA,Gilbert LA,Weissman JS,Berger SL,Kaestner KH

Mechanistic inferences from the crystal structure of fumarylacetoacetate hydrolase with a bound phosphorus-based inhibitor.
The Journal of biological chemistry276(18)15284-91(2001 May)
Bateman RL,Bhanumoorthy P,Witte JF,McClard RW,Grompe M,Timm DE

Point mutations in the murine fumarylacetoacetate hydrolase gene: Animal models for the human genetic disorder hereditary tyrosinemia type 1.
Proceedings of the National Academy of Sciences of the United States of America98(2)641-5(2001 Jan)
Aponte JL,Sega GA,Hauser LJ,Dhar MS,Withrow CM,Carpenter DA,Rinchik EM,Culiat CT,Johnson DK

Crystal structure and mechanism of a carbon-carbon bond hydrolase.
Structure (London, England : 1993)7(9)1023-33(1999 Sep)
Timm DE,Mueller HA,Bhanumoorthy P,Harp JM,Bunick GJ

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Fah cDNA ORF clone, Mus musculus(house mouse)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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