Axin2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Axin2
Entrez Gene ID	29134
Full Name	axin 2
Synonyms	axil,axin-2
General protein information	Preferred Names axin 2 Names axin-2 axin-like protein axis inhibition protein 2 conductin
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q32.1
Summary	inhibits axis formation; acts as a negative regulator of the Wnt signaling pathway by inducing GSK-3beta-dependent phosphorylation of beta-catenin [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_024355.1	NP_077331.1	axin-2

Pathways from BioSystems

Homologies

Bos taurus (cattle)	AXIN2	NP_001179228.1
Pan troglodytes (chimpanzee)	AXIN2	XP_001163162.1
Mus musculus (house mouse)	Axin2	NP_056547.3
Rattus norvegicus (Norway rat)	Axin2	NP_077331.1
Canis lupus familiaris (dog)	AXIN2	XP_548025.2
Danio rerio (zebrafish)	axin2	NP_571636.1
Homo sapiens (human)	AXIN2	NP_004646.3
Gallus gallus (chicken)	AXIN2	NP_989822.1

Gene Ontology
Bibliography

Related articles in PubMed

Axin-2 knockdown promote mitochondrial biogenesis and dopaminergic neurogenesis by regulating Wnt/β-catenin signaling in rat model of Parkinson's disease.
Singh S, Mishra A, Mohanbhai SJ, Tiwari V, Chaturvedi RK, Khurana S, Shukla S
Free radical biology & medicine12973-87(2018 12)

Inhibitory effect of 2-(piperidinoethoxyphenyl)-3-(4-hydroxyphenyl)-2H-benzo(b)pyran (K-1) on human primary endometrial hyperplasial cells mediated via combined suppression of Wnt/β-catenin signaling and PI3K/Akt survival pathway.
Chandra V, Fatima I, Manohar M, Popli P, Sirohi VK, Hussain MK, Hajela K, Sankhwar P, Dwivedi A
Cell death & disease5e1380(2014 Aug)

Up-regulation of Axin2 by dexamethasone promotes adipocyte differentiation in ROB-C26 mesenchymal progenitor cells.
Naito M, Mikami Y, Takagi M, Takahashi T
Cell and tissue research354(3)761-70(2013 Dec)

Wnt/β-catenin and Bmp signals control distinct sets of transcription factors in cardiac progenitor cells.
Klaus A, Müller M, Schulz H, Saga Y, Martin JF, Birchmeier W
Proceedings of the National Academy of Sciences of the United States of America109(27)10921-6(2012 Jul)

Gone with the Wnt: the canonical Wnt signaling axis is present and androgen dependent in the rodent gubernaculum.
Chen N, Harisis GN, Farmer P, Buraundi S, Sourial M, Southwell BR, Balic A, Hutson JM
Journal of pediatric surgery46(12)2363-9(2011 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Axin2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Axin2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa06924	NM_024355.1 Latest version!	Rattus norvegicus axin 2 (Axin2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Axin2 ( NM_024355.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_077331.1 Rattus norvegicus axin 2 (Axin2), mRNA.

Price & Availability↑

CloneID	ORa06924
Clone ID Related Accession (Same CDS sequence)	NM_024355.1
Accession Version	NM_024355.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2517bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577116800000
Organism	Rattus norvegicus(Norway rat)
Product	axin-2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF017757.1. On Jun 25, 2006 this sequence version replaced XM_001081593.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF017757.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGAGTAGCG CTGTGTTAGT GACTCTCCTT CCAGATCCAA GCAGCAGCTT CCGCGAGGAT 
GCTCCGCGGC CCCCGGTTCC CGGAGAAGAA GGGGAGACCC CACCGTGTCA GCCTAGCGTG 
GGCAAGGTCC AGTCCACCAA ACCTATGCCT GTCTCCTCTA ACGCTAGGCG GAATGAAGAT 
GGGCTGGGGG AGCCCGAGGG GCGGGCCTCC CCAGATTCCC CTCTGACCAG GTGGACCAAG 
TCTTTGCACT CCTTGTTGGG GGACCAAGAT GGTGCATACC TCTTCCGGAC TTTCCTGGAG 
AGGGAGAAAT GTGTGGATAC CCTGGACTTC TGGTTTGCCT GCAATGGGTT CAGGCAGATG 
AACTTGAAGG ATACCAAAAC TTTGCGAGTG GCCAAAGCAA TCTACAAGAG GTACATTGAG 
AACAACAGTG TTGTCTCCAA ACAGCTGAAA CCCGCCACCA AGACCTACAT AAGAGATGGC 
ATCAAGAAGC AGCAGATCGG CTCGGTCATG TTTGACCAGG CGCAGACGGA GATTCAGGCG 
GTGATGGAGG AAAATGCCTA TCAGGTGTTC TTGACTTCTG ACATATACCT CGAATATGTG 
AGGAGTGGGG GAGAAAACAC AGCTTACATG AGCAATGGGG GACTGGGGAG CCTAAAGGTC 
TTATGTGGCT ACCTCCCCAC CCTGAATGAG GAAGAGGAGT GGACATGTGC CGACCTGAAG 
TGCAAACTTT CACCCACCGT GGTTGGCCTA TCCAGCAAAA CTCTCCGGGC CACAGCGAGC 
GTGAGATCCA CAGAAACGGC TGAAAACGGA TTCAGATCCT TCAAGAGAAG CGAACCGGTT 
AATCCTTATC ACGTAGGTTC TGGCTATGTC TTTGCACCAG CCACCAGCGC CAACGACAGC 
GAGTTATCCA GCGACGCGCT GACCGACGAT TCCATGTCCA TGACAGACAG TAGCGTAGAT 
GGAATCCCTC CTTACCGCAT GGGGAGTAAG AAACAACTCC AGAGAGAGAT GCACCGCAGT 
GTGAAGGCCA ATGGCCAAGT GTCTCTACCT CACTTCCCGA GAACCCACCG CCTGCCCAAG 
GAGATGACGC CCGTGGAACC TGCTGCCTTC GCCGCAGAGC TCATCTCCAG GCTGGAGAAG 
CTGAAACTGG AGCTGGAGAG CCGCCACAGC CTGGAGGAAC GGCTGCAGCA GATCCGGGAG 
GATGAAGAAA AGGAGGGGTC TGAGCAGGCC CTGAGCTCAC GGGATGGAGC ACCGGTCCAA 
CACCCCCTGG CCCTCTTACC CTCTGGCAGC TATGAAGAGG ACCCACAAAC CATCTTGGAC 
GACCACCTGT CCAGGGTCCT CAAGACCCCC GGCTGCCAGT CCCCTGGTGT GGGCCGCTAC 
AGCCCACGCT CCCGCTCCCC CGACCACCAC CACCACCACC ATCAGCAGTG TCACGCCCTT 
CTTCCAACTG GGGGCAAGCT GCCCCCCGAG GCTGCTTGCC CGCTCCTTGG AGGCAAGAGC 
TTCCTGACCA AACAGACGAC GAAGCACGTC CACCACCACT ACATCCACCA CCACGCCGTC 
CCTAAGACCA AGGAGGAGAT CGAGGCAGAA GCCACACAGA GAGTACGCTG CCTCTGCCCT 
GGAGGCACAG ATTATTACTG CTACTCCAAG TGCAAGAGCC ACTCGAAGCC TCCAGAGCCC 
CTCCCTGGGG AGCAGTTTTG TGGCAGCAGA GGTGGCACCT TGCCAAAACG GAATACGAAA 
GGCACAGAAC CGGGTCTGGC ACTGCCGGCC AGGGAAGGAG GGATGTCCAG TGCAGCAGGG 
GCCCCTCAGC TTCCTGGGGA AGAAGGAGAC CGGTCACAGG ATGTCTGGCA GTGGATGTTG 
GAGAGTGAGC GTCAGAGCAA GTCCAAGCCC CATAGTACCC AAAGCATAAG AAAGAGCTAC 
CCGTTGGAGT CTGCCCGCGC GCCCCCAGGC GAACGAGTCA GCCGGCACCA TCTGCTGGGG 
GCCAGTGGAC ACCCCCGCTC AGCGGCCCGG GCTCACCCAT TTACCCAGGA CCCTGCCATG 
CCTCCCCTAA CCCCACCCAA CACCTTGGCG CAGCTAGAGG AAGCCTGCCG CAGGCTGGCC 
GAGGTGTCAA AGCCCCAGAA ACAGAGGTGC TGCGTGGCCA GTCAGCAGAG GGACAGGAAC 
CACCCAGCCA CAGGTCAGGC AGGACCCACA TCCTTCTCCA ACCCGAGCCT GGCTTCAGAA 
GATCACAAAG AGCCAAAGAG ACTGGCTAGT GTCCACGCAC TCCAAGCCAG CGAGCTGATT 
GTTACCTACT TTTTCTGTGG AGAAGAAATT CCATACAGGA GGATGCTGAA GGCGCAGAGC 
TTGACTCTGG GCCACTTCAA GGAGCAGCTC AGCAAAAAGG GAAATTACAG GTATTACTTC 
AAGAAGGCGA GTGACGAATT TGCCTGTGGA GCAGTCTTTG AGGAGATCTG GGATGATGAG 
ACAGTGCTCC CCATGTACGA AGGCAGGATC CTGGGCAAAG TGGAGAGGAT CGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_077331.1
CDS	85..2601
Translation	MSSAVLVTLLPDPSSSFREDAPRPPVPGEEGETPPCQPSVGKVQSTKPMPVSSNARRNEDGLGEPEGRASPDSPLTRWTKSLHSLLGDQDGAYLFRTFLEREKCVDTLDFWFACNGFRQMNLKDTKTLRVAKAIYKRYIENNSVVSKQLKPATKTYIRDGIKKQQIGSVMFDQAQTEIQAVMEENAYQVFLTSDIYLEYVRSGGENTAYMSNGGLGSLKVLCGYLPTLNEEEEWTCADLKCKLSPTVVGLSSKTLRATASVRSTETAENGFRSFKRSEPVNPYHVGSGYVFAPATSANDSELSSDALTDDSMSMTDSSVDGIPPYRMGSKKQLQREMHRSVKANGQVSLPHFPRTHRLPKEMTPVEPAAFAAELISRLEKLKLELESRHSLEERLQQIREDEEKEGSEQALSSRDGAPVQHPLALLPSGSYEEDPQTILDDHLSRVLKTPGCQSPGVGRYSPRSRSPDHHHHHHQQCHALLPTGGKLPPEAACPLLGGKSFLTKQTTKHVHHHYIHHHAVPKTKEEIEAEATQRVRCLCPGGTDYYCYSKCKSHSKPPEPLPGEQFCGSRGGTLPKRNTKGTEPGLALPAREGGMSSAAGAPQLPGEEGDRSQDVWQWMLESERQSKSKPHSTQSIRKSYPLESARAPPGERVSRHHLLGASGHPRSAARAHPFTQDPAMPPLTPPNTLAQLEEACRRLAEVSKPQKQRCCVASQQRDRNHPATGQAGPTSFSNPSLASEDHKEPKRLASVHALQASELIVTYFFCGEEIPYRRMLKAQSLTLGHFKEQLSKKGNYRYYFKKASDEFACGAVFEEIWDDETVLPMYEGRILGKVERID

Target ORF information:

RefSeq Version	NM_024355.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus axin 2 (Axin2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024355.1

ORF Insert Sequence:

ATGAGTAGCG CTGTGTTAGT GACTCTCCTT CCAGATCCAA GCAGCAGCTT CCGCGAGGAT 
GCTCCGCGGC CCCCGGTTCC CGGAGAAGAA GGGGAGACCC CACCGTGTCA GCCTAGCGTG 
GGCAAGGTCC AGTCCACCAA ACCTATGCCT GTCTCCTCTA ACGCTAGGCG GAATGAAGAT 
GGGCTGGGGG AGCCCGAGGG GCGGGCCTCC CCAGATTCCC CTCTGACCAG GTGGACCAAG 
TCTTTGCACT CCTTGTTGGG GGACCAAGAT GGTGCATACC TCTTCCGGAC TTTCCTGGAG 
AGGGAGAAAT GTGTGGATAC CCTGGACTTC TGGTTTGCCT GCAATGGGTT CAGGCAGATG 
AACTTGAAGG ATACCAAAAC TTTGCGAGTG GCCAAAGCAA TCTACAAGAG GTACATTGAG 
AACAACAGTG TTGTCTCCAA ACAGCTGAAA CCCGCCACCA AGACCTACAT AAGAGATGGC 
ATCAAGAAGC AGCAGATCGG CTCGGTCATG TTTGACCAGG CGCAGACGGA GATTCAGGCG 
GTGATGGAGG AAAATGCCTA TCAGGTGTTC TTGACTTCTG ACATATACCT CGAATATGTG 
AGGAGTGGGG GAGAAAACAC AGCTTACATG AGCAATGGGG GACTGGGGAG CCTAAAGGTC 
TTATGTGGCT ACCTCCCCAC CCTGAATGAG GAAGAGGAGT GGACATGTGC CGACCTGAAG 
TGCAAACTTT CACCCACCGT GGTTGGCCTA TCCAGCAAAA CTCTCCGGGC CACAGCGAGC 
GTGAGATCCA CAGAAACGGC TGAAAACGGA TTCAGATCCT TCAAGAGAAG CGAACCGGTT 
AATCCTTATC ACGTAGGTTC TGGCTATGTC TTTGCACCAG CCACCAGCGC CAACGACAGC 
GAGTTATCCA GCGACGCGCT GACCGACGAT TCCATGTCCA TGACAGACAG TAGCGTAGAT 
GGAATCCCTC CTTACCGCAT GGGGAGTAAG AAACAACTCC AGAGAGAGAT GCACCGCAGT 
GTGAAGGCCA ATGGCCAAGT GTCTCTACCT CACTTCCCGA GAACCCACCG CCTGCCCAAG 
GAGATGACGC CCGTGGAACC TGCTGCCTTC GCCGCAGAGC TCATCTCCAG GCTGGAGAAG 
CTGAAACTGG AGCTGGAGAG CCGCCACAGC CTGGAGGAAC GGCTGCAGCA GATCCGGGAG 
GATGAAGAAA AGGAGGGGTC TGAGCAGGCC CTGAGCTCAC GGGATGGAGC ACCGGTCCAA 
CACCCCCTGG CCCTCTTACC CTCTGGCAGC TATGAAGAGG ACCCACAAAC CATCTTGGAC 
GACCACCTGT CCAGGGTCCT CAAGACCCCC GGCTGCCAGT CCCCTGGTGT GGGCCGCTAC 
AGCCCACGCT CCCGCTCCCC CGACCACCAC CACCACCACC ATCAGCAGTG TCACGCCCTT 
CTTCCAACTG GGGGCAAGCT GCCCCCCGAG GCTGCTTGCC CGCTCCTTGG AGGCAAGAGC 
TTCCTGACCA AACAGACGAC GAAGCACGTC CACCACCACT ACATCCACCA CCACGCCGTC 
CCTAAGACCA AGGAGGAGAT CGAGGCAGAA GCCACACAGA GAGTACGCTG CCTCTGCCCT 
GGAGGCACAG ATTATTACTG CTACTCCAAG TGCAAGAGCC ACTCGAAGCC TCCAGAGCCC 
CTCCCTGGGG AGCAGTTTTG TGGCAGCAGA GGTGGCACCT TGCCAAAACG GAATACGAAA 
GGCACAGAAC CGGGTCTGGC ACTGCCGGCC AGGGAAGGAG GGATGTCCAG TGCAGCAGGG 
GCCCCTCAGC TTCCTGGGGA AGAAGGAGAC CGGTCACAGG ATGTCTGGCA GTGGATGTTG 
GAGAGTGAGC GTCAGAGCAA GTCCAAGCCC CATAGTACCC AAAGCATAAG AAAGAGCTAC 
CCGTTGGAGT CTGCCCGCGC GCCCCCAGGC GAACGAGTCA GCCGGCACCA TCTGCTGGGG 
GCCAGTGGAC ACCCCCGCTC AGCGGCCCGG GCTCACCCAT TTACCCAGGA CCCTGCCATG 
CCTCCCCTAA CCCCACCCAA CACCTTGGCG CAGCTAGAGG AAGCCTGCCG CAGGCTGGCC 
GAGGTGTCAA AGCCCCAGAA ACAGAGGTGC TGCGTGGCCA GTCAGCAGAG GGACAGGAAC 
CACCCAGCCA CAGGTCAGGC AGGACCCACA TCCTTCTCCA ACCCGAGCCT GGCTTCAGAA 
GATCACAAAG AGCCAAAGAG ACTGGCTAGT GTCCACGCAC TCCAAGCCAG CGAGCTGATT 
GTTACCTACT TTTTCTGTGG AGAAGAAATT CCATACAGGA GGATGCTGAA GGCGCAGAGC 
TTGACTCTGG GCCACTTCAA GGAGCAGCTC AGCAAAAAGG GAAATTACAG GTATTACTTC 
AAGAAGGCGA GTGACGAATT TGCCTGTGGA GCAGTCTTTG AGGAGATCTG GGATGATGAG 
ACAGTGCTCC CCATGTACGA AGGCAGGATC CTGGGCAAAG TGGAGAGGAT CGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Axin-2 knockdown promote mitochondrial biogenesis and dopaminergic neurogenesis by regulating Wnt/β-catenin signaling in rat model of Parkinson's disease.
Free radical biology & medicine12973-87(2018 12)
Singh S,Mishra A,Mohanbhai SJ,Tiwari V,Chaturvedi RK,Khurana S,Shukla S

Inhibitory effect of 2-(piperidinoethoxyphenyl)-3-(4-hydroxyphenyl)-2H-benzo(b)pyran (K-1) on human primary endometrial hyperplasial cells mediated via combined suppression of Wnt/β-catenin signaling and PI3K/Akt survival pathway.
Cell death & disease5e1380(2014 Aug)
Chandra V,Fatima I,Manohar M,Popli P,Sirohi VK,Hussain MK,Hajela K,Sankhwar P,Dwivedi A

Up-regulation of Axin2 by dexamethasone promotes adipocyte differentiation in ROB-C26 mesenchymal progenitor cells.
Cell and tissue research354(3)761-70(2013 Dec)
Naito M,Mikami Y,Takagi M,Takahashi T

Wnt/β-catenin and Bmp signals control distinct sets of transcription factors in cardiac progenitor cells.
Proceedings of the National Academy of Sciences of the United States of America109(27)10921-6(2012 Jul)
Klaus A,Müller M,Schulz H,Saga Y,Martin JF,Birchmeier W

Gone with the Wnt: the canonical Wnt signaling axis is present and androgen dependent in the rodent gubernaculum.
Journal of pediatric surgery46(12)2363-9(2011 Dec)
Chen N,Harisis GN,Farmer P,Buraundi S,Sourial M,Southwell BR,Balic A,Hutson JM

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Axin2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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