Mtm1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mtm1
Entrez Gene ID	288762
Full Name	myotubularin 1
General protein information	Preferred Names myotubularin 1 Names myotubularin X-linked myotubular myopathy gene 1 phosphatidylinositol-3,5-bisphosphate 3-phosphatase phosphatidylinositol-3-phosphate phosphatase
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 6 Map Location: 6q12

mRNA and Protein(s)

mRNA	Protein	Name
XM_008764484.2	XP_008762706.1	myotubularin isoform X2
XM_008764483.2	XP_008762705.1	myotubularin isoform X1
NM_001013047.1	NP_001013065.1	myotubularin

Pathways from BioSystems

Homologies

Bos taurus (cattle)	MTM1	NP_001193354.1
Gallus gallus (chicken)	MTM1	XP_004940916.1
Homo sapiens (human)	MTM1	NP_000243.1
Pan troglodytes (chimpanzee)	MTM1	XP_003317805.1
Canis lupus familiaris (dog)	MTM1	XP_005641991.1
Danio rerio (zebrafish)	mtm1	NP_001032773.1
Xenopus tropicalis (tropical clawed frog)	mtm1	NP_001015828.1
Mus musculus (house mouse)	Mtm1	NP_001157662.1
Macaca mulatta (Rhesus monkey)	MTM1	XP_002806476.1
Rattus norvegicus (Norway rat)	Mtm1	NP_001013065.1
Caenorhabditis elegans (roundworm)	mtm-1	NP_491531.2

Gene Ontology
Bibliography

Related articles in PubMed

Lack of myotubularin (MTM1) leads to muscle hypotrophy through unbalanced regulation of the autophagy and ubiquitin-proteasome pathways.
Al-Qusairi L, Prokic I, Amoasii L, Kretz C, Messaddeq N, Mandel JL, Laporte J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology27(8)3384-94(2013 Aug)

Site-specific Mtm1 mutagenesis by an AAV-Cre vector reveals that myotubularin is essential in adult muscle.
Joubert R, Vignaud A, Le M, Moal C, Messaddeq N, Buj-Bello A
Human molecular genetics22(9)1856-66(2013 May)

Myotubularin controls desmin intermediate filament architecture and mitochondrial dynamics in human and mouse skeletal muscle.
Hnia K, Tronchère H, Tomczak KK, Amoasii L, Schultz P, Beggs AH, Payrastre B, Mandel JL, Laporte J
The Journal of clinical investigation121(1)70-85(2011 Jan)

AAV-mediated intramuscular delivery of myotubularin corrects the myotubular myopathy phenotype in targeted murine muscle and suggests a function in plasma membrane homeostasis.
Buj-Bello A, Fougerousse F, Schwab Y, Messaddeq N, Spehner D, Pierson CR, Durand M, Kretz C, Danos O, Douar AM, Beggs AH, Schultz P, Montus M, Denèfle P, Mandel JL
Human molecular genetics17(14)2132-43(2008 Jul)

Myotubularin regulates the function of the late endosome through the gram domain-phosphatidylinositol 3,5-bisphosphate interaction.
Tsujita K, Itoh T, Ijuin T, Yamamoto A, Shisheva A, Laporte J, Takenawa T
The Journal of biological chemistry279(14)13817-24(2004 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Mtm1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mtm1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa03092	NM_001013047.1 Latest version!	Rattus norvegicus myotubularin 1 (Mtm1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
ORa44731	XM_008764483.2 Latest version!	Rattus norvegicus myotubularin 1 (Mtm1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
ORa44732	XM_008764484.2 Latest version!	Rattus norvegicus myotubularin 1 (Mtm1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mtm1 ( NM_001013047.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001013065.1 Rattus norvegicus myotubularin 1 (Mtm1), mRNA.

Price & Availability↑

CloneID	ORa03092
Clone ID Related Accession (Same CDS sequence)	NM_001013047.1
Accession Version	NM_001013047.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1662bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577289600000
Organism	Rattus norvegicus(Norway rat)
Product	myotubularin
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC091225.1. On Apr 20, 2005 this sequence version replaced XM_213822.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC091225.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCGTCCT CGTCAGCCTC TGACTGTGAT GCACACCCCG TGGAGCGTGA GTCCATGAGG 
AAGGTGTCTC AAGATGGAGT CCGTCAGGAT ATGAGCAAGA GTGGGCCTCG CCTCCCAGGG 
GAATCAGCCA TCACTGACAA GGAAGTCATC TACATTTGTC CCTTCAGCGG CCCCGTAAAG 
GGACGACTTT ACATCACCAA TTACCGTCTC TACCTGAGAA GTCTGGAGAC GGACTTGGCT 
CCGATTCTTG ACGTCCCCCT AGGCGTGATA TCGAGAATAG AGAAAATGGG AGGCGTGACG 
AGTCGAGGAG AGAATTCCTA CGGCCTTGAT ATCACCTGCA AAGACCTGAG GAACCTGAGG 
TTCGCTCTGA AGCAGGAAGG ACACAGCAGG AGGGACATCT TTGACGTCCT CACCAGACAC 
GCCTTCCCCC TGGCTTACAA CCTGCCGTTG TTTGCATTCG TGAACGAGGA GAAGTTTAAA 
GTGGATGGAT GGGCGATTTA CAACCCGGTT GAAGAGTACA GAAGGCAGGG CCTCCCCGAT 
CGCCATTGGC GGATAAGTTT CGTCAATCAG CGCTACGAGC TCTGTGACAC CTACCCTGCC 
CTCCTGGTCG TCCCCTACCG TGCGTCCGAT GATGACCTCA GAAGAGTTGC AACCTTTAGG 
TCCAGAAACC GGATTCCCGT GCTGTCGTGG ATCCACCCAG AGAACAGGGC GGCGATCATG 
CGGTGCAGTC AGCCTCTGGT TGGTGTGGGC GGGAAGAGAA GCAGAGATGA TGAGAGATAC 
CTGGACATCA TCCGGGAAAC CAATAAGCAG ACCTCGAAGC TCACAATTTA CGATGCGCGG 
CCCGGCGTCA ATGCGGTGGC CAACAAGGCA ACGGGAGGCG GCTATGAGGG CGAGGACGCG 
TACCCTCACG CGGAGCTCTC CTTCCTGGAC ATCCACAACA TCCACGTGAT GCGGGAATCC 
TTACGGAGGG TGAGGGACAT CGTGTACCCC CACGTGGAGG AAGCTCATTG GCTGTCCAGC 
TTGGAGTCCA CCCATTGGTT AGAGCACATC AAGCTTCTCC TCACTGGTGC CATCCGGGTC 
GCAGACAAGG TGGCATCGGG GCTGAGTTCA GTCCTCGTGC ACTGCAGTGA CGGCTGGGAC 
CGGACGGCTC AACTGACCAC GCTGGCCATG CTGATGCTCG ATGGCTTCTA CCGCAGCATC 
GAGGGCTTTG AGATCCTGGT GCAGAAGGAG TGGATCAGCT TCGGACACAA GTTTTCATCT 
AGAATTGGCC ACGGTGACAA GAACCACGCG GATGCCGACC GCTCCCCGAT TTTCCTGCAG 
TTCATCGACT GCGTGTGGCA GATGACGAAG CAGTTCCCCA CAGCTTTCGA GTTCAACGAG 
TGCTTCCTGG TTGCCATCTT GGATCACCTG TACAGCTGCC GGTTCGGGAC TTTCTTACTA 
AACTGTGAGG CGGCACGGGA GAGACAGAGA CTCGCAGAAA GGACGGTGTC TGTGTGGTCC 
CTGATCAACA GCAACAAAGA CGAATTCACA AACCCGTTCT ACGCAAGGGA GAGCAACCGC 
GTGATCTACC CGGTCACCAG CGTGCGCCAC CTGGAACTGT GGGTGAATTA CTACATCCGG 
TGGAACCCCA GGATCCGGCA GCAGCAGCCC CACCCCATGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001013065.1
CDS	46..1707
Translation	MASSSASDCDAHPVERESMRKVSQDGVRQDMSKSGPRLPGESAITDKEVIYICPFSGPVKGRLYITNYRLYLRSLETDLAPILDVPLGVISRIEKMGGVTSRGENSYGLDITCKDLRNLRFALKQEGHSRRDIFDVLTRHAFPLAYNLPLFAFVNEEKFKVDGWAIYNPVEEYRRQGLPDRHWRISFVNQRYELCDTYPALLVVPYRASDDDLRRVATFRSRNRIPVLSWIHPENRAAIMRCSQPLVGVGGKRSRDDERYLDIIRETNKQTSKLTIYDARPGVNAVANKATGGGYEGEDAYPHAELSFLDIHNIHVMRESLRRVRDIVYPHVEEAHWLSSLESTHWLEHIKLLLTGAIRVADKVASGLSSVLVHCSDGWDRTAQLTTLAMLMLDGFYRSIEGFEILVQKEWISFGHKFSSRIGHGDKNHADADRSPIFLQFIDCVWQMTKQFPTAFEFNECFLVAILDHLYSCRFGTFLLNCEAARERQRLAERTVSVWSLINSNKDEFTNPFYARESNRVIYPVTSVRHLELWVNYYIRWNPRIRQQQPHPM

Target ORF information:

RefSeq Version	NM_001013047.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus myotubularin 1 (Mtm1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001013047.1

ORF Insert Sequence:

ATGGCGTCCT CGTCAGCCTC TGACTGTGAT GCACACCCCG TGGAGCGTGA GTCCATGAGG 
AAGGTGTCTC AAGATGGAGT CCGTCAGGAT ATGAGCAAGA GTGGGCCTCG CCTCCCAGGG 
GAATCAGCCA TCACTGACAA GGAAGTCATC TACATTTGTC CCTTCAGCGG CCCCGTAAAG 
GGACGACTTT ACATCACCAA TTACCGTCTC TACCTGAGAA GTCTGGAGAC GGACTTGGCT 
CCGATTCTTG ACGTCCCCCT AGGCGTGATA TCGAGAATAG AGAAAATGGG AGGCGTGACG 
AGTCGAGGAG AGAATTCCTA CGGCCTTGAT ATCACCTGCA AAGACCTGAG GAACCTGAGG 
TTCGCTCTGA AGCAGGAAGG ACACAGCAGG AGGGACATCT TTGACGTCCT CACCAGACAC 
GCCTTCCCCC TGGCTTACAA CCTGCCGTTG TTTGCATTCG TGAACGAGGA GAAGTTTAAA 
GTGGATGGAT GGGCGATTTA CAACCCGGTT GAAGAGTACA GAAGGCAGGG CCTCCCCGAT 
CGCCATTGGC GGATAAGTTT CGTCAATCAG CGCTACGAGC TCTGTGACAC CTACCCTGCC 
CTCCTGGTCG TCCCCTACCG TGCGTCCGAT GATGACCTCA GAAGAGTTGC AACCTTTAGG 
TCCAGAAACC GGATTCCCGT GCTGTCGTGG ATCCACCCAG AGAACAGGGC GGCGATCATG 
CGGTGCAGTC AGCCTCTGGT TGGTGTGGGC GGGAAGAGAA GCAGAGATGA TGAGAGATAC 
CTGGACATCA TCCGGGAAAC CAATAAGCAG ACCTCGAAGC TCACAATTTA CGATGCGCGG 
CCCGGCGTCA ATGCGGTGGC CAACAAGGCA ACGGGAGGCG GCTATGAGGG CGAGGACGCG 
TACCCTCACG CGGAGCTCTC CTTCCTGGAC ATCCACAACA TCCACGTGAT GCGGGAATCC 
TTACGGAGGG TGAGGGACAT CGTGTACCCC CACGTGGAGG AAGCTCATTG GCTGTCCAGC 
TTGGAGTCCA CCCATTGGTT AGAGCACATC AAGCTTCTCC TCACTGGTGC CATCCGGGTC 
GCAGACAAGG TGGCATCGGG GCTGAGTTCA GTCCTCGTGC ACTGCAGTGA CGGCTGGGAC 
CGGACGGCTC AACTGACCAC GCTGGCCATG CTGATGCTCG ATGGCTTCTA CCGCAGCATC 
GAGGGCTTTG AGATCCTGGT GCAGAAGGAG TGGATCAGCT TCGGACACAA GTTTTCATCT 
AGAATTGGCC ACGGTGACAA GAACCACGCG GATGCCGACC GCTCCCCGAT TTTCCTGCAG 
TTCATCGACT GCGTGTGGCA GATGACGAAG CAGTTCCCCA CAGCTTTCGA GTTCAACGAG 
TGCTTCCTGG TTGCCATCTT GGATCACCTG TACAGCTGCC GGTTCGGGAC TTTCTTACTA 
AACTGTGAGG CGGCACGGGA GAGACAGAGA CTCGCAGAAA GGACGGTGTC TGTGTGGTCC 
CTGATCAACA GCAACAAAGA CGAATTCACA AACCCGTTCT ACGCAAGGGA GAGCAACCGC 
GTGATCTACC CGGTCACCAG CGTGCGCCAC CTGGAACTGT GGGTGAATTA CTACATCCGG 
TGGAACCCCA GGATCCGGCA GCAGCAGCCC CACCCCATGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mtm1 ( XM_008764483.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008762705.1 Rattus norvegicus myotubularin 1 (Mtm1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa44731
Clone ID Related Accession (Same CDS sequence)	XM_008764483.2
Accession Version	XM_008764483.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1875bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	myotubularin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005105.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008764483.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTGTCTAA AATCATGGTG CACGTTTGGC TCATGGAGAA TTTTGTTTCC CTTAGGTTCC 
AGGATGGCGT CCTCGTCAGC CTCTGACTGT GATGCACACC CCGTGGAGCG TGAGTCCATG 
AGGAAGGTGT CTCAAGATGG AGTCCGTCAG GATATGAGCA AGAGTGGGCC TCGCCTCCCA 
GGGGAATCAG CCATCACTGA CAAGGAAGTC ATCTACATTT GTCCCTTCAG CGGCCCCGTA 
AAGGGACGAC TTTACATCAC CAATTACCGT CTCTACCTGA GAAGTCTGGA GACGGACTTG 
GCTCCGATTC TTGACGTCCC CCTAGGCGTG ATATCGAGAA TAGAGAAAAT GGGAGGCGTG 
ACGAGTCGAG GAGAGAATTC CTACGGCCTT GATATCACCT GCAAAGACCT GAGGAACCTG 
AGGTTCGCTC TGAAGCAGGA AGGACACAGC AGGAGGGACA TCTTTGACGT CCTCACCAGA 
CACGCCTTCC CCCTGGCTTA CAACCTGCCG TTGTTTGCAT TCGTGAACGA GGAGAAGTTT 
AAAGTGGATG GATGGGCGAT TTACAACCCG GTTGAAGAGT ACAGAAGGCA GGGCCTCCCC 
GATCGCCATT GGCGGATAAG TTTCGTCAAT CAGCGCTACG AGCTCTGTGA CACCTACCCT 
GCCCTCCTGG TCGTCCCCTA CCGTGCGTCC GATGATGACC TCAGAAGAGT TGCAACCTTT 
AGGTCCAGAA ACCGGATTCC CGTGCTGTCG TGGATCCACC CAGAGAACAG GGCGGCGATC 
ATGCGGTGCA GTCAGCCTCT GGTTGGTGTG GGCGGGAAGA GAAGCAGAGA TGATGAGAGA 
TACCTGGACA TCATCCGGGA AACCAATAAG CAGACCTCGA AGCTCACAAT TTACGATGCG 
CGGCCCGGCG TCAATGCGGT GGCCAACAAG GCAACGGGAG GCGGCTATGA GGGCGAGGAC 
GCGTACCCTC ACGCGGAGCT CTCCTTCCTG GACATCCACA ACATCCACGT GATGCGGGAA 
TCCTTACGGA GGGTGAGGGA CATCGTGTAC CCCCACGTGG AGGAAGCTCA TTGGCTGTCC 
AGCTTGGAGT CCACCCATTG GTTAGAGCAC ATCAAGCTTC TCCTCACTGG TGCCATCCGG 
GTCGCAGACA AGGTGGCATC GGGGCTGAGT TCAGTCCTCG TGCACTGCAG TGACGGCTGG 
GACCGGACGG CTCAACTGAC CACGCTGGCC ATGCTGATGC TCGATGGCTT CTACCGCAGC 
ATCGAGGGCT TTGAGATCCT GGTGCAGAAG GAGTGGATCA GCTTCGGACA CAAGTTTTCA 
TCTAGAATTG GCCACGGTGA CAAGAACCAC GCGGATGCCG ACCGCTCCCC GATTTTCCTG 
CAGTTCATCG ACTGCGTGTG GCAGATGACG AAGCAGTTCC CCACAGCTTT CGAGTTCAAC 
GAGTGCTTCC TGGTTGCCAT CTTGGATCAC CTGTACAGCT GCCGGTTCGG GACTTTCTTA 
CTAAACTGTG AGGCGGCACG GGAGAGACAG AGACTCGCAG AAAGGACGGT GTCTGTGTGG 
TCCCTGATCA ACAGCAACAA AGACGAATTC ACAAACCCGT TCTACGCAAG GGAGAGCAAC 
CGCGTGATCT ACCCGGTCAC CAGCGTGCGC CACCTGGAAC TGTGGGTGAA TTACTACATC 
CGGTGGAACC CCAGGATCCG GCAGCAGCAG CCCCACCCCA TGGAGCAGCG ATATAATGAG 
CTCCTGGCCC TGCGTGACGA TTACATCAAG AAGCTGGAGG AGCTGCAGCT GGCCACGCCC 
ACCAAGCTCA CTGACTCCTC CACCCCGCCT TCCGGTTCCG CACAGATAGC TCCCCGCATG 
CAAACTCACT TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008762705.1
CDS	11..1885
Translation	MCLKSWCTFGSWRILFPLGSRMASSSASDCDAHPVERESMRKVSQDGVRQDMSKSGPRLPGESAITDKEVIYICPFSGPVKGRLYITNYRLYLRSLETDLAPILDVPLGVISRIEKMGGVTSRGENSYGLDITCKDLRNLRFALKQEGHSRRDIFDVLTRHAFPLAYNLPLFAFVNEEKFKVDGWAIYNPVEEYRRQGLPDRHWRISFVNQRYELCDTYPALLVVPYRASDDDLRRVATFRSRNRIPVLSWIHPENRAAIMRCSQPLVGVGGKRSRDDERYLDIIRETNKQTSKLTIYDARPGVNAVANKATGGGYEGEDAYPHAELSFLDIHNIHVMRESLRRVRDIVYPHVEEAHWLSSLESTHWLEHIKLLLTGAIRVADKVASGLSSVLVHCSDGWDRTAQLTTLAMLMLDGFYRSIEGFEILVQKEWISFGHKFSSRIGHGDKNHADADRSPIFLQFIDCVWQMTKQFPTAFEFNECFLVAILDHLYSCRFGTFLLNCEAARERQRLAERTVSVWSLINSNKDEFTNPFYARESNRVIYPVTSVRHLELWVNYYIRWNPRIRQQQPHPMEQRYNELLALRDDYIKKLEELQLATPTKLTDSSTPPSGSAQIAPRMQTHF

Target ORF information:

RefSeq Version	XM_008764483.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus myotubularin 1 (Mtm1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008764483.2

ORF Insert Sequence:

ATGTGTCTAA AATCATGGTG CACGTTTGGC TCATGGAGAA TTTTGTTTCC CTTAGGTTCC 
AGGATGGCGT CCTCGTCAGC CTCTGACTGT GATGCACACC CCGTGGAGCG TGAGTCCATG 
AGGAAGGTGT CTCAAGATGG AGTCCGTCAG GATATGAGCA AGAGTGGGCC TCGCCTCCCA 
GGGGAATCAG CCATCACTGA CAAGGAAGTC ATCTACATTT GTCCCTTCAG CGGCCCCGTA 
AAGGGACGAC TTTACATCAC CAATTACCGT CTCTACCTGA GAAGTCTGGA GACGGACTTG 
GCTCCGATTC TTGACGTCCC CCTAGGCGTG ATATCGAGAA TAGAGAAAAT GGGAGGCGTG 
ACGAGTCGAG GAGAGAATTC CTACGGCCTT GATATCACCT GCAAAGACCT GAGGAACCTG 
AGGTTCGCTC TGAAGCAGGA AGGACACAGC AGGAGGGACA TCTTTGACGT CCTCACCAGA 
CACGCCTTCC CCCTGGCTTA CAACCTGCCG TTGTTTGCAT TCGTGAACGA GGAGAAGTTT 
AAAGTGGATG GATGGGCGAT TTACAACCCG GTTGAAGAGT ACAGAAGGCA GGGCCTCCCC 
GATCGCCATT GGCGGATAAG TTTCGTCAAT CAGCGCTACG AGCTCTGTGA CACCTACCCT 
GCCCTCCTGG TCGTCCCCTA CCGTGCGTCC GATGATGACC TCAGAAGAGT TGCAACCTTT 
AGGTCCAGAA ACCGGATTCC CGTGCTGTCG TGGATCCACC CAGAGAACAG GGCGGCGATC 
ATGCGGTGCA GTCAGCCTCT GGTTGGTGTG GGCGGGAAGA GAAGCAGAGA TGATGAGAGA 
TACCTGGACA TCATCCGGGA AACCAATAAG CAGACCTCGA AGCTCACAAT TTACGATGCG 
CGGCCCGGCG TCAATGCGGT GGCCAACAAG GCAACGGGAG GCGGCTATGA GGGCGAGGAC 
GCGTACCCTC ACGCGGAGCT CTCCTTCCTG GACATCCACA ACATCCACGT GATGCGGGAA 
TCCTTACGGA GGGTGAGGGA CATCGTGTAC CCCCACGTGG AGGAAGCTCA TTGGCTGTCC 
AGCTTGGAGT CCACCCATTG GTTAGAGCAC ATCAAGCTTC TCCTCACTGG TGCCATCCGG 
GTCGCAGACA AGGTGGCATC GGGGCTGAGT TCAGTCCTCG TGCACTGCAG TGACGGCTGG 
GACCGGACGG CTCAACTGAC CACGCTGGCC ATGCTGATGC TCGATGGCTT CTACCGCAGC 
ATCGAGGGCT TTGAGATCCT GGTGCAGAAG GAGTGGATCA GCTTCGGACA CAAGTTTTCA 
TCTAGAATTG GCCACGGTGA CAAGAACCAC GCGGATGCCG ACCGCTCCCC GATTTTCCTG 
CAGTTCATCG ACTGCGTGTG GCAGATGACG AAGCAGTTCC CCACAGCTTT CGAGTTCAAC 
GAGTGCTTCC TGGTTGCCAT CTTGGATCAC CTGTACAGCT GCCGGTTCGG GACTTTCTTA 
CTAAACTGTG AGGCGGCACG GGAGAGACAG AGACTCGCAG AAAGGACGGT GTCTGTGTGG 
TCCCTGATCA ACAGCAACAA AGACGAATTC ACAAACCCGT TCTACGCAAG GGAGAGCAAC 
CGCGTGATCT ACCCGGTCAC CAGCGTGCGC CACCTGGAAC TGTGGGTGAA TTACTACATC 
CGGTGGAACC CCAGGATCCG GCAGCAGCAG CCCCACCCCA TGGAGCAGCG ATATAATGAG 
CTCCTGGCCC TGCGTGACGA TTACATCAAG AAGCTGGAGG AGCTGCAGCT GGCCACGCCC 
ACCAAGCTCA CTGACTCCTC CACCCCGCCT TCCGGTTCCG CACAGATAGC TCCCCGCATG 
CAAACTCACT TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mtm1 ( XM_008764484.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008762706.1 Rattus norvegicus myotubularin 1 (Mtm1), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa44732
Clone ID Related Accession (Same CDS sequence)	XM_008764484.2
Accession Version	XM_008764484.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1872bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	myotubularin isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005105.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008764484.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTGTCTAA AATCATGGTG CACGTTTGGC TCATGGAGAA TTTTGTTTCC CTTAGGTTCC 
AGGATGGCGT CCTCGTCAGC CTCTGACTGT GATGCACACC CCGTGGAGCG TGAGTCCATG 
AGGAAGGTGT CTCAAGATGG AGTCCGTCAG GATATGAGCA AGAGTGGGCC TCGCCTCCCA 
GGGGAATCAG CCATCACTGA CAAGGAAGTC ATCTACATTT GTCCCTTCAG CGGCCCCGTA 
AAGGGACGAC TTTACATCAC CAATTACCGT CTCTACCTGA GAAGTCTGGA GACGGACTTG 
GCTCCGATTC TTGACGTCCC CCTAGGCGTG ATATCGAGAA TAGAGAAAAT GGGAGGCGTG 
ACGAGTCGAG GAGAGAATTC CTACGGCCTT GATATCACCT GCAAAGACCT GAGGAACCTG 
AGGTTCGCTC TGAAGCAGGA AGGACACAGC AGGAGGGACA TCTTTGACGT CCTCACCAGA 
CACGCCTTCC CCCTGGCTTA CAACCTGCCG TTGTTTGCAT TCGTGAACGA GGAGAAGTTT 
AAAGTGGATG GATGGGCGAT TTACAACCCG GTTGAAGAGT ACAGAAGGCA GGGCCTCCCC 
GATCGCCATT GGCGGATAAG TTTCGTCAAT CAGCGCTACG AGCTCTGTGA CACCTACCCT 
GCCCTCCTGG TCGTCCCCTA CCGTGCGTCC GATGATGACC TCAGAAGAGT TGCAACCTTT 
AGGTCCAGAA ACCGGATTCC CGTGCTGTCG TGGATCCACC CAGAGAACAG GGCGGCGATC 
ATGCGGTGCA GTCAGCCTCT GGTTGGTGTG GGCGGGAAGA GAAGCAGAGA TGATGAGAGA 
TACCTGGACA TCATCCGGGA AACCAATAAG CAGACCTCGA AGCTCACAAT TTACGATGCG 
CGGCCCGGCG TCAATGCGGT GGCCAACAAG GCAACGGGAG GCGGCTATGA GGGCGAGGAC 
GCGTACCCTC ACGCGGAGCT CTCCTTCCTG GACATCCACA ACATCCACGT GATGCGGGAA 
TCCTTACGGA GGGTGAGGGA CATCGTGTAC CCCCACGTGG AGGAAGCTCA TTGGCTGTCC 
AGCTTGGAGT CCACCCATTG GTTAGAGCAC ATCAAGCTTC TCCTCACTGG TGCCATCCGG 
GTCGCAGACA AGGTGGCATC GGGGCTGAGT TCAGTCCTCG TGCACTGCAG TGACGGCTGG 
GACCGGACGG CTCAACTGAC CACGCTGGCC ATGCTGATGC TCGATGGCTT CTACCGCAGC 
ATCGAGGGCT TTGAGATCCT GGTGCAGAAG GAGTGGATCA GCTTCGGACA CAAGTTTTCA 
TCTAGAATTG GCCACGGTGA CAAGAACCAC GCGGATGCCG ACCGCTCCCC GATTTTCCTG 
CAGTTCATCG ACTGCGTGTG GCAGATGACG AAGCAGTTCC CCACAGCTTT CGAGTTCAAC 
GAGTGCTTCC TGGTTGCCAT CTTGGATCAC CTGTACAGCT GCCGGTTCGG GACTTTCTTA 
CTAAACTGTG AGGCGGCACG GGAGAGACAG AGACTCGCAG AAAGGACGGT GTCTGTGTGG 
TCCCTGATCA ACAGCAACAA AGACGAATTC ACAAACCCGT TCTACGCAAG GGAGAGCAAC 
CGCGTGATCT ACCCGGTCAC CAGCGTGCGC CACCTGGAAC TGTGGGTGAA TTACTACATC 
CGGTGGAACC CCAGGATCCG GCAGCAGCCC CACCCCATGG AGCAGCGATA TAATGAGCTC 
CTGGCCCTGC GTGACGATTA CATCAAGAAG CTGGAGGAGC TGCAGCTGGC CACGCCCACC 
AAGCTCACTG ACTCCTCCAC CCCGCCTTCC GGTTCCGCAC AGATAGCTCC CCGCATGCAA 
ACTCACTTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008762706.1
CDS	11..1882
Translation	MCLKSWCTFGSWRILFPLGSRMASSSASDCDAHPVERESMRKVSQDGVRQDMSKSGPRLPGESAITDKEVIYICPFSGPVKGRLYITNYRLYLRSLETDLAPILDVPLGVISRIEKMGGVTSRGENSYGLDITCKDLRNLRFALKQEGHSRRDIFDVLTRHAFPLAYNLPLFAFVNEEKFKVDGWAIYNPVEEYRRQGLPDRHWRISFVNQRYELCDTYPALLVVPYRASDDDLRRVATFRSRNRIPVLSWIHPENRAAIMRCSQPLVGVGGKRSRDDERYLDIIRETNKQTSKLTIYDARPGVNAVANKATGGGYEGEDAYPHAELSFLDIHNIHVMRESLRRVRDIVYPHVEEAHWLSSLESTHWLEHIKLLLTGAIRVADKVASGLSSVLVHCSDGWDRTAQLTTLAMLMLDGFYRSIEGFEILVQKEWISFGHKFSSRIGHGDKNHADADRSPIFLQFIDCVWQMTKQFPTAFEFNECFLVAILDHLYSCRFGTFLLNCEAARERQRLAERTVSVWSLINSNKDEFTNPFYARESNRVIYPVTSVRHLELWVNYYIRWNPRIRQQPHPMEQRYNELLALRDDYIKKLEELQLATPTKLTDSSTPPSGSAQIAPRMQTHF

Target ORF information:

RefSeq Version	XM_008764484.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus myotubularin 1 (Mtm1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008764484.2

ORF Insert Sequence:

ATGTGTCTAA AATCATGGTG CACGTTTGGC TCATGGAGAA TTTTGTTTCC CTTAGGTTCC 
AGGATGGCGT CCTCGTCAGC CTCTGACTGT GATGCACACC CCGTGGAGCG TGAGTCCATG 
AGGAAGGTGT CTCAAGATGG AGTCCGTCAG GATATGAGCA AGAGTGGGCC TCGCCTCCCA 
GGGGAATCAG CCATCACTGA CAAGGAAGTC ATCTACATTT GTCCCTTCAG CGGCCCCGTA 
AAGGGACGAC TTTACATCAC CAATTACCGT CTCTACCTGA GAAGTCTGGA GACGGACTTG 
GCTCCGATTC TTGACGTCCC CCTAGGCGTG ATATCGAGAA TAGAGAAAAT GGGAGGCGTG 
ACGAGTCGAG GAGAGAATTC CTACGGCCTT GATATCACCT GCAAAGACCT GAGGAACCTG 
AGGTTCGCTC TGAAGCAGGA AGGACACAGC AGGAGGGACA TCTTTGACGT CCTCACCAGA 
CACGCCTTCC CCCTGGCTTA CAACCTGCCG TTGTTTGCAT TCGTGAACGA GGAGAAGTTT 
AAAGTGGATG GATGGGCGAT TTACAACCCG GTTGAAGAGT ACAGAAGGCA GGGCCTCCCC 
GATCGCCATT GGCGGATAAG TTTCGTCAAT CAGCGCTACG AGCTCTGTGA CACCTACCCT 
GCCCTCCTGG TCGTCCCCTA CCGTGCGTCC GATGATGACC TCAGAAGAGT TGCAACCTTT 
AGGTCCAGAA ACCGGATTCC CGTGCTGTCG TGGATCCACC CAGAGAACAG GGCGGCGATC 
ATGCGGTGCA GTCAGCCTCT GGTTGGTGTG GGCGGGAAGA GAAGCAGAGA TGATGAGAGA 
TACCTGGACA TCATCCGGGA AACCAATAAG CAGACCTCGA AGCTCACAAT TTACGATGCG 
CGGCCCGGCG TCAATGCGGT GGCCAACAAG GCAACGGGAG GCGGCTATGA GGGCGAGGAC 
GCGTACCCTC ACGCGGAGCT CTCCTTCCTG GACATCCACA ACATCCACGT GATGCGGGAA 
TCCTTACGGA GGGTGAGGGA CATCGTGTAC CCCCACGTGG AGGAAGCTCA TTGGCTGTCC 
AGCTTGGAGT CCACCCATTG GTTAGAGCAC ATCAAGCTTC TCCTCACTGG TGCCATCCGG 
GTCGCAGACA AGGTGGCATC GGGGCTGAGT TCAGTCCTCG TGCACTGCAG TGACGGCTGG 
GACCGGACGG CTCAACTGAC CACGCTGGCC ATGCTGATGC TCGATGGCTT CTACCGCAGC 
ATCGAGGGCT TTGAGATCCT GGTGCAGAAG GAGTGGATCA GCTTCGGACA CAAGTTTTCA 
TCTAGAATTG GCCACGGTGA CAAGAACCAC GCGGATGCCG ACCGCTCCCC GATTTTCCTG 
CAGTTCATCG ACTGCGTGTG GCAGATGACG AAGCAGTTCC CCACAGCTTT CGAGTTCAAC 
GAGTGCTTCC TGGTTGCCAT CTTGGATCAC CTGTACAGCT GCCGGTTCGG GACTTTCTTA 
CTAAACTGTG AGGCGGCACG GGAGAGACAG AGACTCGCAG AAAGGACGGT GTCTGTGTGG 
TCCCTGATCA ACAGCAACAA AGACGAATTC ACAAACCCGT TCTACGCAAG GGAGAGCAAC 
CGCGTGATCT ACCCGGTCAC CAGCGTGCGC CACCTGGAAC TGTGGGTGAA TTACTACATC 
CGGTGGAACC CCAGGATCCG GCAGCAGCCC CACCCCATGG AGCAGCGATA TAATGAGCTC 
CTGGCCCTGC GTGACGATTA CATCAAGAAG CTGGAGGAGC TGCAGCTGGC CACGCCCACC 
AAGCTCACTG ACTCCTCCAC CCCGCCTTCC GGTTCCGCAC AGATAGCTCC CCGCATGCAA 
ACTCACTTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Lack of myotubularin (MTM1) leads to muscle hypotrophy through unbalanced regulation of the autophagy and ubiquitin-proteasome pathways.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology27(8)3384-94(2013 Aug)
Al-Qusairi L,Prokic I,Amoasii L,Kretz C,Messaddeq N,Mandel JL,Laporte J

Site-specific Mtm1 mutagenesis by an AAV-Cre vector reveals that myotubularin is essential in adult muscle.
Human molecular genetics22(9)1856-66(2013 May)
Joubert R,Vignaud A,Le M,Moal C,Messaddeq N,Buj-Bello A

Myotubularin controls desmin intermediate filament architecture and mitochondrial dynamics in human and mouse skeletal muscle.
The Journal of clinical investigation121(1)70-85(2011 Jan)
Hnia K,Tronchère H,Tomczak KK,Amoasii L,Schultz P,Beggs AH,Payrastre B,Mandel JL,Laporte J

AAV-mediated intramuscular delivery of myotubularin corrects the myotubular myopathy phenotype in targeted murine muscle and suggests a function in plasma membrane homeostasis.
Human molecular genetics17(14)2132-43(2008 Jul)
Buj-Bello A,Fougerousse F,Schwab Y,Messaddeq N,Spehner D,Pierson CR,Durand M,Kretz C,Danos O,Douar AM,Beggs AH,Schultz P,Montus M,Denèfle P,Mandel JL

Myotubularin regulates the function of the late endosome through the gram domain-phosphatidylinositol 3,5-bisphosphate interaction.
The Journal of biological chemistry279(14)13817-24(2004 Apr)
Tsujita K,Itoh T,Ijuin T,Yamamoto A,Shisheva A,Laporte J,Takenawa T

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Mtm1 cDNA ORF clone, Rattus norvegicus(Norway rat)

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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