| Gene Symbol | Ppm1d |
| Entrez Gene ID | 287585 |
| Full Name | protein phosphatase, Mg2+/Mn2+ dependent, 1D |
| Synonyms | Wip1 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Rattus norvegicus(Norway rat) |
| Genome |
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Ppm1d cDNA ORF clone, Rattus norvegicus(Norway rat)
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Gene
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Clones
gRNAs
The following Ppm1d gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ppm1d cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID ORa04340 Clone ID Related Accession (Same CDS sequence) NM_001105825.2 Accession Version NM_001105825.2 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 1797bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1532707200000 Organism Rattus norvegicus(Norway rat) Product protein phosphatase 1D Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC162058.1, FM140338.1 and AABR07030169.1. On Sep 27, 2011 this sequence version replaced NM_001105825.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC162058.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741ATGGCGGGGC TGTACTCTCT GGGAGTGAGC GTCTTCTCTG ACCAGGGCGG GAGGAAGTAC
ATGGAGGACG TAACTCAGAT TGTGGTGGAA CCCGAGCCCG CTGCGGAGGA CAAGCCGGCG
CCGGTACCCC GGCGGGCGCT CGGGCTGCCG GCGACCCCAT CTCTCGTCGG CGTCGGGCCA
TCGGGAAAAG GCCCGGCGGC GGCCCGCGAC CCTGCCCCGG ACGCCGCGGC CTCGCTACCC
GCTGGACGCT GCTGTCGCCG CCGCTCCTCG GTGGCCTTCT TCGCTGTGTG CGACGGGCAC
GGCGGGCGGG AGGCGGCACA GTTTGCCCGG GAGCACTTGT GGGGTTTCAT CAAGAAGCAG
AAAGGCTTCA CCTCGTCCGA GCCCGCCAAG GTGTGCGCTG CCATCCGCAA AGGCTTCCTC
GCCTGTCACC TCGCCATGTG GAAGAAACTG GCAGAATGGC CAAAGACTAT GACAGGTCTT
CCCAGCACGT CCGGAACAAC TGCCAGTGTG GTTATCATAC GGGGCATGAA GATGTATGTA
GCTCATGTAG GTGACTCTGG AGTGGTCCTT GGAATTCAGG ATGACCCAAA GGATGATTTT
GTGAGAGCTG TGGAGGTGAC ACAAGATCAC AAGCCAGAAC TTCCCAAGGA AAGAGAAAGA
ATTGAAGGAC TTGGCGGGAG TGTGATGAAC AAGTCTGGAG TGAATCGTGT AGTTTGGAAA
AGACCTCGGC TCACTCACAG TGGACCTGTG AGAAGGAGTA CAGTCATTGA TCAGATTCCT
TTCTTGGCCG TAGCAAGAGC ACTTGGTGAC TTGTGGAGCT ATGATTTCTT CAGTGGTAAG
TTTGTGGTGT CACCTGAACC GGACACCAGT GTCCACACAC TTGACCCCCA GAAGCACAAG
TATATTATCC TGGGAAGTGA TGGGCTTTGG AATATGGTTC CACCTCAAGA TGCCATCTCC
ATGTGCCAAG ACCAAGAGGA GAAAAAATAC TTGATGGGTG AGCAAGGACA GTCTTGTGCT
AAAATGCTTG TGAATCGAGC ACTTGGCCGC TGGAGGCAGC GTATGCTTCG AGCAGATAAC
ACAAGTGCCA TAGTAATCTG CATCTCTCCA GAAGTAGATA ATCAAGGGAA CTTTACCAAT
GAAGATGAGC TCTTTCTGAA CCTGACTGAT AGCCCTACTT ACAACAGCCA AGAAACCTGT
GTGATGACTC CTTCTCCAAG TTCTACACCA CCAGTCAAGT CACTGGAAGA AGATCCATGG
CCAAGGCTGA ACTCTAAGGA CCATATACCT GCCCTTGTTC GCAGTAATGC CTTCTCAGAG
AAGTTTTTAG AGGTCCCAGC TGAGATAGCT CGAGGAAGTA TCCAGACTGT AGTCATGACC
TCAAAAGACT CAGAGACACT TGAAGAAAAT TGCCCCAAAG CCCTGACTTT AAGGATTCAT
GATTCTTTGA ATAATACTCT GTCAGTTGGC CTCATGCCAA CCAATTCAAC AAATACTATC
ATGGACCAAA AAAATTTAAA GATGTCAACT CCAGGTCAAA TGAAAGCTCA AGAAGTTGAA
AGAACCCCTC CAGCCAATTT TAAAAGGACA TTAGAAGAAT CCAACTCTGG TCCCCTTATG
AAGAAGCATC GACGAAATGG CTTAAGTCGA AATAGCGGGG CCCAAGCTTC GAGTCTCCCC
ACAGCATCCC AGCGCAGGCA CTCTGTCACA CTGACCATGA GGCGCAGACT CCGGGGCCAG
AAGAAGATGG GGAATCCTCT TTTACATCAG CACCGGAAAA CAGTGTGTGT GTGCTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_001099295.2 CDS 219..2015 Translation 
Target ORF information:
RefSeq Version NM_001105825.2 Organism Rattus norvegicus(Norway rat) Definition Rattus norvegicus protein phosphatase, Mg2+/Mn2+ dependent, 1D (Ppm1d), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_001105825.2
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741ATGGCGGGGC TGTACTCTCT GGGAGTGAGC GTCTTCTCTG ACCAGGGCGG GAGGAAGTAC
ATGGAGGACG TAACTCAGAT TGTGGTGGAA CCCGAGCCCG CTGCGGAGGA CAAGCCGGCG
CCGGTACCCC GGCGGGCGCT CGGGCTGCCG GCGACCCCAT CTCTCGTCGG CGTCGGGCCA
TCGGGAAAAG GCCCGGCGGC GGCCCGCGAC CCTGCCCCGG ACGCCGCGGC CTCGCTACCC
GCTGGACGCT GCTGTCGCCG CCGCTCCTCG GTGGCCTTCT TCGCTGTGTG CGACGGGCAC
GGCGGGCGGG AGGCGGCACA GTTTGCCCGG GAGCACTTGT GGGGTTTCAT CAAGAAGCAG
AAAGGCTTCA CCTCGTCCGA GCCCGCCAAG GTGTGCGCTG CCATCCGCAA AGGCTTCCTC
GCCTGTCACC TCGCCATGTG GAAGAAACTG GCAGAATGGC CAAAGACTAT GACAGGTCTT
CCCAGCACGT CCGGAACAAC TGCCAGTGTG GTTATCATAC GGGGCATGAA GATGTATGTA
GCTCATGTAG GTGACTCTGG AGTGGTCCTT GGAATTCAGG ATGACCCAAA GGATGATTTT
GTGAGAGCTG TGGAGGTGAC ACAAGATCAC AAGCCAGAAC TTCCCAAGGA AAGAGAAAGA
ATTGAAGGAC TTGGCGGGAG TGTGATGAAC AAGTCTGGAG TGAATCGTGT AGTTTGGAAA
AGACCTCGGC TCACTCACAG TGGACCTGTG AGAAGGAGTA CAGTCATTGA TCAGATTCCT
TTCTTGGCCG TAGCAAGAGC ACTTGGTGAC TTGTGGAGCT ATGATTTCTT CAGTGGTAAG
TTTGTGGTGT CACCTGAACC GGACACCAGT GTCCACACAC TTGACCCCCA GAAGCACAAG
TATATTATCC TGGGAAGTGA TGGGCTTTGG AATATGGTTC CACCTCAAGA TGCCATCTCC
ATGTGCCAAG ACCAAGAGGA GAAAAAATAC TTGATGGGTG AGCAAGGACA GTCTTGTGCT
AAAATGCTTG TGAATCGAGC ACTTGGCCGC TGGAGGCAGC GTATGCTTCG AGCAGATAAC
ACAAGTGCCA TAGTAATCTG CATCTCTCCA GAAGTAGATA ATCAAGGGAA CTTTACCAAT
GAAGATGAGC TCTTTCTGAA CCTGACTGAT AGCCCTACTT ACAACAGCCA AGAAACCTGT
GTGATGACTC CTTCTCCAAG TTCTACACCA CCAGTCAAGT CACTGGAAGA AGATCCATGG
CCAAGGCTGA ACTCTAAGGA CCATATACCT GCCCTTGTTC GCAGTAATGC CTTCTCAGAG
AAGTTTTTAG AGGTCCCAGC TGAGATAGCT CGAGGAAGTA TCCAGACTGT AGTCATGACC
TCAAAAGACT CAGAGACACT TGAAGAAAAT TGCCCCAAAG CCCTGACTTT AAGGATTCAT
GATTCTTTGA ATAATACTCT GTCAGTTGGC CTCATGCCAA CCAATTCAAC AAATACTATC
ATGGACCAAA AAAATTTAAA GATGTCAACT CCAGGTCAAA TGAAAGCTCA AGAAGTTGAA
AGAACCCCTC CAGCCAATTT TAAAAGGACA TTAGAAGAAT CCAACTCTGG TCCCCTTATG
AAGAAGCATC GACGAAATGG CTTAAGTCGA AATAGCGGGG CCCAAGCTTC GAGTCTCCCC
ACAGCATCCC AGCGCAGGCA CTCTGTCACA CTGACCATGA GGCGCAGACT CCGGGGCCAG
AAGAAGATGG GGAATCCTCT TTTACATCAG CACCGGAAAA CAGTGTGTGT GTGCTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
Interaction of Wip1 and NF-κB regulates neuroinflammatory response in astrocytes.
Inflammation research : official journal of the European Histamine Research Society ... [et al.]66(11)1011-1019(2017 Nov)
Xu F,Chen L,Zhao X,Zhong H,Cui L,Jiang L,Huang H,Li L,Zeng S,Li M
De Novo Truncating Mutations in the Last and Penultimate Exons of PPM1D Cause an Intellectual Disability Syndrome.
American journal of human genetics100(4)650-658(2017 Apr)
Jansen S,Geuer S,Pfundt R,Brough R,Ghongane P,Herkert JC,Marco EJ,Willemsen MH,Kleefstra T,Hannibal M,Shieh JT,Lynch SA,Flinter F,FitzPatrick DR,Gardham A,Bernhard B,Ragge N,Newbury-Ecob R,Bernier R,Kvarnung M,Magnusson EA,Wessels MW,van Slegtenhorst MA,Monaghan KG,de Vries P,Veltman JA,,Lord CJ,Vissers LE,de Vries BB
Up-regulation of Wip1 involves in neuroinflammation of retinal astrocytes after optic nerve crush via NF-κB signaling pathway.
Inflammation research : official journal of the European Histamine Research Society ... [et al.]65(9)709-15(2016 Sep)
Zhong H,Cui L,Xu F,Chen L,Jiang L,Huang H,Xu J,Zhao X,Li L,Zeng S,Li M
Involvement of dysregulated Wip1 in manganese-induced p53 signaling and neuronal apoptosis.
Toxicology letters235(1)17-27(2015 May)
Ma X,Han J,Wu Q,Liu H,Shi S,Wang C,Wang Y,Xiao J,Zhao J,Jiang J,Wan C
Wip1 controls global heterochromatin silencing via ATM/BRCA1-dependent DNA methylation.
Cancer cell24(4)528-41(2013 Oct)
Filipponi D,Muller J,Emelyanov A,Bulavin DV
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