| Gene Symbol | Gamt |
| Entrez Gene ID | 25257 |
| Full Name | guanidinoacetate N-methyltransferase |
| Synonyms | GMT |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Rattus norvegicus(Norway rat) |
| Genome | |
| Summary | catalyzes the last step of creatine biosynthesis [RGD, Feb 2006]. |
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Gamt cDNA ORF clone, Rattus norvegicus(Norway rat)
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Gene
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Clones
gRNAs
The following Gamt gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gamt cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID ORa00948 Clone ID Related Accession (Same CDS sequence) NM_012793.2 Accession Version NM_012793.2 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 711bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1577116800000 Organism Rattus norvegicus(Norway rat) Product guanidinoacetate N-methyltransferase Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from FQ225896.1, FM040945.1 and BF524958.1. On or before Sep 7, 2012 this sequence version replaced NM_001207007.1, NM_012793.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: FQ225896.1, J03588.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.
1
61
121
181
241
301
361
421
481
541
601
661ATGAGTTCTT CTGCAGCCAG CCCGCTTTTC GCGCCTGGCG AGGACTGCGG CCCCGCGTGG
CGCGCGGCCC CCGCGGCCTA TGATACGTCT GACACGCACC TGCAGATCCT GGGCAAGCCA
GTAATGGAGC GTTGGGAGAC CCCCTACATG CATTCGCTGG CGGCTGCTGC TGCCTCCAGA
GGGGGCCGGG TCCTGGAAGT GGGCTTTGGG ATGGCCATTG CAGCCTCCAG GGTGCAGCAG
GCCCCCATAA AGGAACACTG GATTATTGAA TGCAACGATG GGGTCTTCCA GCGTCTACAA
AACTGGGCCC TGAAGCAGCC ACATAAGGTT GTTCCCTTGA AAGGCCTGTG GGAGGAGGTG
GCACCTACAC TGCCTGATGG TCACTTTGAT GGGATTCTAT ACGACACATA TCCACTGTCT
GAAGAGACCT GGCACACTCA CCAGTTCAAC TTTATTAAGA CTCATGCTTT CCGTTTGCTG
AAGCCTGGGG GTATCCTCAC TTACTGCAAC CTCACGTCCT GGGGGGAACT CATGAAGTCC
AAGTACACAG ACATCACTGC CATGTTTGAG GAGACTCAGG TGCCTGCACT GCTGGAAGCT
GGCTTCCAGA GAGAAAACAT CTGTACAGAG GTGATGGCGC TGGTGCCCCC AGCCGACTGC
CGCTACTATG CCTTCCCTCA GATGATCACA CCCCTGGTCA CCAAGCACTG AThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_036925.2 CDS 54..764 Translation 
Target ORF information:
RefSeq Version NM_012793.2 Organism Rattus norvegicus(Norway rat) Definition Rattus norvegicus guanidinoacetate N-methyltransferase (Gamt), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_012793.2
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661ATGAGTTCTT CTGCAGCCAG CCCGCTTTTC GCGCCTGGCG AGGACTGCGG CCCCGCGTGG
CGCGCGGCCC CCGCGGCCTA TGATACGTCT GACACGCACC TGCAGATCCT GGGCAAGCCA
GTAATGGAGC GTTGGGAGAC CCCCTACATG CATTCGCTGG CGGCTGCTGC TGCCTCCAGA
GGGGGCCGGG TCCTGGAAGT GGGCTTTGGG ATGGCCATTG CAGCCTCCAG GGTGCAGCAG
GCCCCCATAA AGGAACACTG GATTATTGAA TGCAACGATG GGGTCTTCCA GCGTCTACAA
AACTGGGCCC TGAAGCAGCC ACATAAGGTT GTTCCCTTGA AAGGCCTGTG GGAGGAGGTG
GCACCTACAC TGCCTGATGG TCACTTTGAT GGGATTCTAT ACGACACATA TCCACTGTCT
GAAGAGACCT GGCACACTCA CCAGTTCAAC TTTATTAAGA CTCATGCTTT CCGTTTGCTG
AAGCCTGGGG GTATCCTCAC TTACTGCAAC CTCACGTCCT GGGGGGAACT CATGAAGTCC
AAGTACACAG ACATCACTGC CATGTTTGAG GAGACTCAGG TGCCTGCACT GCTGGAAGCT
GGCTTCCAGA GAGAAAACAT CTGTACAGAG GTGATGGCGC TGGTGCCCCC AGCCGACTGC
CGCTACTATG CCTTCCCTCA GATGATCACA CCCCTGGTCA CCAAGCACTG AThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
Mild guanidinoacetate increase under partial guanidinoacetate methyltransferase deficiency strongly affects brain cell development.
Neurobiology of disease7914-27(2015 Jul)
Hanna-El-Daher L,Béard E,Henry H,Tenenbaum L,Braissant O
Creatine synthesis and transport during rat embryogenesis: spatiotemporal expression of AGAT, GAMT and CT1.
BMC developmental biology59(2005 May)
Braissant O,Henry H,Villard AM,Speer O,Wallimann T,Bachmann C
Catalytic mechanism of guanidinoacetate methyltransferase: crystal structures of guanidinoacetate methyltransferase ternary complexes.
Biochemistry43(45)14385-94(2004 Nov)
Komoto J,Yamada T,Takata Y,Konishi K,Ogawa H,Gomi T,Fujioka M,Takusagawa F
Severely altered guanidino compound levels, disturbed body weight homeostasis and impaired fertility in a mouse model of guanidinoacetate N-methyltransferase (GAMT) deficiency.
Human molecular genetics13(9)905-21(2004 May)
Schmidt A,Marescau B,Boehm EA,Renema WK,Peco R,Das A,Steinfeld R,Chan S,Wallis J,Davidoff M,Ullrich K,Waldschütz R,Heerschap A,De Deyn PP,Neubauer S,Isbrandt D
Monoclinic guanidinoacetate methyltransferase and gadolinium ion-binding characteristics.
Acta crystallographica. Section D, Biological crystallography59(Pt 9)1589-96(2003 Sep)
Komoto J,Takata Y,Yamada T,Konishi K,Ogawa H,Gomi T,Fujioka M,Takusagawa F
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