Fgfr4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fgfr4
Entrez Gene ID	25114
Full Name	fibroblast growth factor receptor 4
General protein information	Preferred Names fibroblast growth factor receptor 4 Names fibroblast growth factor receptor 4 FGFR-4
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 17 Map Location: 17p14
Summary	fibroblast growth factor receptor subtype expressed in lung and kidney [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006253606.3	XP_006253668.1	fibroblast growth factor receptor 4 isoform X1
NM_001109904.1	NP_001103374.1	fibroblast growth factor receptor 4 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	FGFR4	NP_002002.3
Canis lupus familiaris (dog)	FGFR4	XP_005619229.1
Gallus gallus (chicken)	FGFR4	XP_003642120.2
Pan troglodytes (chimpanzee)	FGFR4	XP_518127.4
Bos taurus (cattle)	FGFR4	NP_001179513.1
Mus musculus (house mouse)	Fgfr4	NP_032037.2
Rattus norvegicus (Norway rat)	Fgfr4	NP_001103374.1
Xenopus tropicalis (tropical clawed frog)	fgfr4	NP_001016323.1
Macaca mulatta (Rhesus monkey)	FGFR4	XP_001087243.1
Danio rerio (zebrafish)	fgfr4	NP_571505.1

Gene Ontology
Bibliography

Related articles in PubMed

Vitamin D treatment attenuates cardiac FGF23/FGFR4 signaling and hypertrophy in uremic rats.
Leifheit-Nestler M, Grabner A, Hermann L, Richter B, Schmitz K, Fischer DC, Yanucil C, Faul C, Haffner D
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association32(9)1493-1503(2017 Sep)

Regulation of renal phosphate transport by FGF23 is mediated by FGFR1 and FGFR4.
Gattineni J, Alphonse P, Zhang Q, Mathews N, Bates CM, Baum M
American journal of physiology. Renal physiology306(3)F351-8(2014 Feb)

Regulation of serum 1,25(OH)2 vitamin D3 levels by fibroblast growth factor 23 is mediated by FGF receptors 3 and 4.
Gattineni J, Twombley K, Goetz R, Mohammadi M, Baum M
American journal of physiology. Renal physiology301(2)F371-7(2011 Aug)

Fibroblast growth factor receptor 4 regulates tumor invasion by coupling fibroblast growth factor signaling to extracellular matrix degradation.
Sugiyama N, Varjosalo M, Meller P, Lohi J, Hyytiäinen M, Kilpinen S, Kallioniemi O, Ingvarsen S, Engelholm LH, Taipale J, Alitalo K, Keski-Oja J, Lehti K
Cancer research70(20)7851-61(2010 Oct)

FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4.
Xie MH, Holcomb I, Deuel B, Dowd P, Huang A, Vagts A, Foster J, Liang J, Brush J, Gu Q, Hillan K, Goddard A, Gurney AL
Cytokine11(10)729-35(1999 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Fgfr4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fgfr4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa00711	NM_001109904.1 Latest version!	Rattus norvegicus fibroblast growth factor receptor 4 (Fgfr4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00
ORa37678	XM_006253606.3 Latest version!	Rattus norvegicus fibroblast growth factor receptor 4 (Fgfr4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fgfr4 ( NM_001109904.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001103374.1 Rattus norvegicus fibroblast growth factor receptor 4 (Fgfr4), mRNA.

Price & Availability↑

CloneID	ORa00711
Clone ID Related Accession (Same CDS sequence)	NM_001109904.1
Accession Version	NM_001109904.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2403bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577203200000
Organism	Rattus norvegicus(Norway rat)
Product	fibroblast growth factor receptor 4 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB743466.1 and BC100260.1. On or before Oct 13, 2007 this sequence version replaced XM_344570.3, XM_001066753.1, XM_001066809.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: BC100260.1 [ECO:0000331] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTGGCTGC TGTTGGCTTT GTTGAGCATC TTTCAGGAGA CACCAGCCTT CTCCCTTGAG 
GCCTCTGAGG AAATGGAACA GGAGCCCTGC CCAGCCCCAA TCTCGGAGCA GCAAGAGCAG 
GTGTTGACTG TGGCCCTTGG GCAGCCTGTG CGGCTATGCT GTGGCCGCAC TGAGCGTGGT 
CGTCATTGGT ACAAGGAGGG CAGCCGTTTA GCATCTGCTG GGAGAGTACG GGGCTGGAGA 
GGCCGCCTGG AGATCGCCAG CTTCCTTCCT GAGGATGCTG GCCGGTACCT CTGCCTGGCC 
CGTGGCTCCA TGACTGTCGT ACACAATCTT ACTTTGATTA TGGATGACTC CTTACCCTCC 
ATCAATAACG AGGACCCCAA GACCCTCAGC AGCTCCTCGA GTGGGCACTC CTACCTGCAG 
CAAGCACCTT ACTGGACACA CCCCCAACGC ATGGAGAAGA AACTGCACGC GGTACCTGCC 
GGGAACACTG TCAAATTCCG CTGTCCAGCT GCAGGGAACC CCATGCCCAC CATCCACTGG 
CTCAAGAACG GACAGGCCTT CCACGGAGAG AATCGTATCG GAGGCATTCG GCTGCGTCAC 
CAACACTGGA GCCTCGTGAT GGAGAGCGTG GTGCCCTCAG ACCGTGGCAC GTACACGTGT 
CTTGTGGAGA ACTCTCTGGG TAGCATTCGC TACAGCTATC TGCTGGATGT GCTGGAGCGG 
TCCCCGCACC GGCCCATCCT GCAGGCGGGA CTCCCAGCCA ACACCACGGC TGTGGTTGGC 
AGCAACGTGG AGCTGCTGTG CAAGGTGTAC AGTGACGCCC AGCCGCACAT CCAGTGGCTG 
AAGCACATCG TTATCAACGG CAGCAGTTTC GGCGCTGATG GTTTCCCCTA CGTACAAGTC 
CTGAAGACAA CAGACATCAA TAGCTCAGAG GTGGAGGTGC TGTATCTGAG GAACGTGTCG 
GCTGAGGATG CAGGGGAGTA CACCTGCCTG GCGGGCAACT CCATCGGCCT CTCCTACCAG 
TCAGCGTGGC TCACAGTGCT ACCCGCAGAG GAAGAAGACC TCGCGTGGAC AACAGCAACA 
TCGGAGGCCA GATATACAGA TATTATCCTA TATGTATCTG GCTCACTGGC TTTGGTTTTG 
CTCCTGCTGC TGGCCGGGGT GTATCACCGA CAAGCAATCC ACGGCCACCA CTCTCGACAG 
CCTGTCACTG TACAGAAGCT GTCCCGGTTC CCTTTGGCCC GGCAGTTCTC CTTGGAGTCG 
AGGTCCTCTG GCAAGTCAAG TTTGTCCCTG GTGCGAGGTG TCCGGCTCTC CTCCAGTGGC 
CCGCCCTTGC TCACGGGCCT TGTGAGTCTA GACCTACCTC TCGATCCACT TTGGGAGTTC 
CCCCGGGACA GGCTGGTGCT CGGAAAGCCC CTGGGTGAGG GCTGCTTTGG GCAAGTGGTT 
CGTGCAGAAG CCCTTGGCAT GGATTCCTCC CGGCCAGACC AAACCAGCAC CGTGGCTGTG 
AAGATGCTGA AAGACAATGC CTCCGACAAG GATTTGGCAG ACCTGATCTC TGAGATGGAG 
ATGATGAAGC TAATCGGAAG ACACAAGAAC ATCATTAACC TGCTGGGTGT CTGCACTCAG 
GAAGGGCCCC TGTATGTGAT TGTGGAATAT GCGGCCAAGG GAAACCTTCG GGAATTCCTC 
CGTGCCCGGC GTCCCCCAGG CCCTGATCTC AGCCCTGATG GGCCTCGGAG CAGCGAAGGA 
CCGCTCTCCT TCCCGGCCCT GGTCTCCTGT GCCTACCAGG TGGCCCGAGG CATGCAGTAT 
CTGGAGTCTC GGAAGTGCAT CCACCGGGAC CTGGCTGCCC GAAACGTGCT GGTGACCGAG 
GATGACGTGA TGAAGATCGC TGACTTTGGT CTGGCCCGTG GTGTCCACCA CATCGACTAC 
TATAAGAAAA CCAGCAATGG CCGCCTGCCA GTCAAGTGGA TGGCTCCTGA GGCGTTGTTT 
GACCGTGTAT ACACACACCA GAGTGACGTG TGGTCCTTCG GGATCCTGCT GTGGGAAATC 
TTCACCCTCG GGGGCTCCCC ATACCCCGGC ATCCCAGTGG AGGAGCTGTT CTCACTGCTG 
CGAGAGGGGC ACAGGATGGA GCGGCCCCCA AACTGCCCCT CAGAGCTGTA TGGGCTAATG 
AGGGAGTGTT GGCACGCAGC TCCTTCTCAG AGGCCGACTT TTAAGCAGCT GGTGGAAGCT 
CTGGACAAGG TCCTGCTGGC TGTCTCTGAA GAGTACCTTG ACCTCCGCCT GACCTTTGGA 
CCCTATTCCC CCAACAATGG GGATGCCAGC AGCACGTGCT CCTCCAGCGA CTCGGTTTTC 
AGCCACGACC CTTTGCCCCT CGAGCCAAGC CCCTTCCCAT TTCCTGAGGC GCAGACCACA 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001103374.1
CDS	176..2578
Translation	MWLLLALLSIFQETPAFSLEASEEMEQEPCPAPISEQQEQVLTVALGQPVRLCCGRTERGRHWYKEGSRLASAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMTVVHNLTLIMDDSLPSINNEDPKTLSSSSSGHSYLQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPMPTIHWLKNGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENSLGSIRYSYLLDVLERSPHRPILQAGLPANTTAVVGSNVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTTDINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPAEEEDLAWTTATSEARYTDIILYVSGSLALVLLLLLAGVYHRQAIHGHHSRQPVTVQKLSRFPLARQFSLESRSSGKSSLSLVRGVRLSSSGPPLLTGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEALGMDSSRPDQTSTVAVKMLKDNASDKDLADLISEMEMMKLIGRHKNIINLLGVCTQEGPLYVIVEYAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPALVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDDVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMERPPNCPSELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPNNGDASSTCSSSDSVFSHDPLPLEPSPFPFPEAQTT

Target ORF information:

RefSeq Version	NM_001109904.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus fibroblast growth factor receptor 4 (Fgfr4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001109904.1

ORF Insert Sequence:

ATGTGGCTGC TGTTGGCTTT GTTGAGCATC TTTCAGGAGA CACCAGCCTT CTCCCTTGAG 
GCCTCTGAGG AAATGGAACA GGAGCCCTGC CCAGCCCCAA TCTCGGAGCA GCAAGAGCAG 
GTGTTGACTG TGGCCCTTGG GCAGCCTGTG CGGCTATGCT GTGGCCGCAC TGAGCGTGGT 
CGTCATTGGT ACAAGGAGGG CAGCCGTTTA GCATCTGCTG GGAGAGTACG GGGCTGGAGA 
GGCCGCCTGG AGATCGCCAG CTTCCTTCCT GAGGATGCTG GCCGGTACCT CTGCCTGGCC 
CGTGGCTCCA TGACTGTCGT ACACAATCTT ACTTTGATTA TGGATGACTC CTTACCCTCC 
ATCAATAACG AGGACCCCAA GACCCTCAGC AGCTCCTCGA GTGGGCACTC CTACCTGCAG 
CAAGCACCTT ACTGGACACA CCCCCAACGC ATGGAGAAGA AACTGCACGC GGTACCTGCC 
GGGAACACTG TCAAATTCCG CTGTCCAGCT GCAGGGAACC CCATGCCCAC CATCCACTGG 
CTCAAGAACG GACAGGCCTT CCACGGAGAG AATCGTATCG GAGGCATTCG GCTGCGTCAC 
CAACACTGGA GCCTCGTGAT GGAGAGCGTG GTGCCCTCAG ACCGTGGCAC GTACACGTGT 
CTTGTGGAGA ACTCTCTGGG TAGCATTCGC TACAGCTATC TGCTGGATGT GCTGGAGCGG 
TCCCCGCACC GGCCCATCCT GCAGGCGGGA CTCCCAGCCA ACACCACGGC TGTGGTTGGC 
AGCAACGTGG AGCTGCTGTG CAAGGTGTAC AGTGACGCCC AGCCGCACAT CCAGTGGCTG 
AAGCACATCG TTATCAACGG CAGCAGTTTC GGCGCTGATG GTTTCCCCTA CGTACAAGTC 
CTGAAGACAA CAGACATCAA TAGCTCAGAG GTGGAGGTGC TGTATCTGAG GAACGTGTCG 
GCTGAGGATG CAGGGGAGTA CACCTGCCTG GCGGGCAACT CCATCGGCCT CTCCTACCAG 
TCAGCGTGGC TCACAGTGCT ACCCGCAGAG GAAGAAGACC TCGCGTGGAC AACAGCAACA 
TCGGAGGCCA GATATACAGA TATTATCCTA TATGTATCTG GCTCACTGGC TTTGGTTTTG 
CTCCTGCTGC TGGCCGGGGT GTATCACCGA CAAGCAATCC ACGGCCACCA CTCTCGACAG 
CCTGTCACTG TACAGAAGCT GTCCCGGTTC CCTTTGGCCC GGCAGTTCTC CTTGGAGTCG 
AGGTCCTCTG GCAAGTCAAG TTTGTCCCTG GTGCGAGGTG TCCGGCTCTC CTCCAGTGGC 
CCGCCCTTGC TCACGGGCCT TGTGAGTCTA GACCTACCTC TCGATCCACT TTGGGAGTTC 
CCCCGGGACA GGCTGGTGCT CGGAAAGCCC CTGGGTGAGG GCTGCTTTGG GCAAGTGGTT 
CGTGCAGAAG CCCTTGGCAT GGATTCCTCC CGGCCAGACC AAACCAGCAC CGTGGCTGTG 
AAGATGCTGA AAGACAATGC CTCCGACAAG GATTTGGCAG ACCTGATCTC TGAGATGGAG 
ATGATGAAGC TAATCGGAAG ACACAAGAAC ATCATTAACC TGCTGGGTGT CTGCACTCAG 
GAAGGGCCCC TGTATGTGAT TGTGGAATAT GCGGCCAAGG GAAACCTTCG GGAATTCCTC 
CGTGCCCGGC GTCCCCCAGG CCCTGATCTC AGCCCTGATG GGCCTCGGAG CAGCGAAGGA 
CCGCTCTCCT TCCCGGCCCT GGTCTCCTGT GCCTACCAGG TGGCCCGAGG CATGCAGTAT 
CTGGAGTCTC GGAAGTGCAT CCACCGGGAC CTGGCTGCCC GAAACGTGCT GGTGACCGAG 
GATGACGTGA TGAAGATCGC TGACTTTGGT CTGGCCCGTG GTGTCCACCA CATCGACTAC 
TATAAGAAAA CCAGCAATGG CCGCCTGCCA GTCAAGTGGA TGGCTCCTGA GGCGTTGTTT 
GACCGTGTAT ACACACACCA GAGTGACGTG TGGTCCTTCG GGATCCTGCT GTGGGAAATC 
TTCACCCTCG GGGGCTCCCC ATACCCCGGC ATCCCAGTGG AGGAGCTGTT CTCACTGCTG 
CGAGAGGGGC ACAGGATGGA GCGGCCCCCA AACTGCCCCT CAGAGCTGTA TGGGCTAATG 
AGGGAGTGTT GGCACGCAGC TCCTTCTCAG AGGCCGACTT TTAAGCAGCT GGTGGAAGCT 
CTGGACAAGG TCCTGCTGGC TGTCTCTGAA GAGTACCTTG ACCTCCGCCT GACCTTTGGA 
CCCTATTCCC CCAACAATGG GGATGCCAGC AGCACGTGCT CCTCCAGCGA CTCGGTTTTC 
AGCCACGACC CTTTGCCCCT CGAGCCAAGC CCCTTCCCAT TTCCTGAGGC GCAGACCACA 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Fgfr4 ( XM_006253606.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006253668.1 Rattus norvegicus fibroblast growth factor receptor 4 (Fgfr4), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa37678
Clone ID Related Accession (Same CDS sequence)	XM_006253606.3
Accession Version	XM_006253606.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2406bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	fibroblast growth factor receptor 4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005116.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006253606.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTGGCTGC TGTTGGCTTT GTTGAGCATC TTTCAGGAGA CACCAGCCTT CTCCCTTGAG 
GCCTCTGAGG AAATGGAACA GGAGCCCTGC CCAGCCCCAA TCTCGGAGCA GCAAGAGCAG 
GTGTTGACTG TGGCCCTTGG GCAGCCTGTG CGGCTATGCT GTGGCCGCAC TGAGCGTGGT 
CGTCATTGGT ACAAGGAGGG CAGCCGTTTA GCATCTGCTG GGAGAGTACG GGGCTGGAGA 
GGCCGCCTGG AGATCGCCAG CTTCCTTCCT GAGGATGCTG GCCGGTACCT CTGCCTGGCC 
CGTGGCTCCA TGACTGTCGT ACACAATCTT ACTTTGATTA TGGATGACTC CTTACCCTCC 
ATCAATAACG AGGACCCCAA GACCCTCAGC AGCTCCTCGA GTGGGCACTC CTACCTGCAG 
CAAGCACCTT ACTGGACACA CCCCCAACGC ATGGAGAAGA AACTGCACGC GGTACCTGCC 
GGGAACACTG TCAAATTCCG CTGTCCAGCT GCAGGGAACC CCATGCCCAC CATCCACTGG 
CTCAAGAACG GACAGGCCTT CCACGGAGAG AATCGTATCG GAGGCATTCG GCTGCGTCAC 
CAACACTGGA GCCTCGTGAT GGAGAGCGTG GTGCCCTCAG ACCGTGGCAC GTACACGTGT 
CTTGTGGAGA ACTCTCTGGG TAGCATTCGC TACAGCTATC TGCTGGATGT GCTGGAGCGG 
TCCCCGCACC GGCCCATCCT GCAGGCGGGA CTCCCAGCCA ACACCACGGC TGTGGTTGGC 
AGCAACGTGG AGCTGCTGTG CAAGGTGTAC AGTGACGCCC AGCCGCACAT CCAGTGGCTG 
AAGCACATCG TTATCAACGG CAGCAGTTTC GGCGCTGATG GTTTCCCCTA CGTACAAGTC 
CTGAAGACAA CAGACATCAA TAGCTCAGAG GTGGAGGTGC TGTATCTGAG GAACGTGTCG 
GCTGAGGATG CAGGGGAGTA CACCTGCCTG GCGGGCAACT CCATCGGCCT CTCCTACCAG 
TCAGCGTGGC TCACAGTGCT ACCCGAAGCA GAGGAAGAAG ACCTCGCGTG GACAACAGCA 
ACATCGGAGG CCAGATATAC AGATATTATC CTATATGTAT CTGGCTCACT GGCTTTGGTT 
TTGCTCCTGC TGCTGGCCGG GGTGTATCAC CGACAAGCAA TCCACGGCCA CCACTCTCGA 
CAGCCTGTCA CTGTACAGAA GCTGTCCCGG TTCCCTTTGG CCCGGCAGTT CTCCTTGGAG 
TCGAGGTCCT CTGGCAAGTC AAGTTTGTCC CTGGTGCGAG GTGTCCGGCT CTCCTCCAGT 
GGCCCGCCCT TGCTCACGGG CCTTGTGAGT CTAGACCTAC CTCTCGATCC ACTTTGGGAG 
TTCCCCCGGG ACAGGCTGGT GCTCGGAAAG CCCCTGGGTG AGGGCTGCTT TGGGCAAGTG 
GTTCGTGCAG AAGCCCTTGG CATGGATTCC TCCCGGCCAG ACCAAACCAG CACCGTGGCT 
GTGAAGATGC TGAAAGACAA TGCCTCCGAC AAGGATTTGG CAGACCTGAT CTCTGAGATG 
GAGATGATGA AGCTAATCGG AAGACACAAG AACATCATTA ACCTGCTGGG TGTCTGCACT 
CAGGAAGGGC CCCTGTATGT GATTGTGGAA TATGCGGCCA AGGGAAACCT TCGGGAATTC 
CTCCGTGCCC GGCGTCCCCC AGGCCCTGAT CTCAGCCCTG ATGGGCCTCG GAGCAGCGAA 
GGACCGCTCT CCTTCCCGGC CCTGGTCTCC TGTGCCTACC AGGTGGCCCG AGGCATGCAG 
TATCTGGAGT CTCGGAAGTG CATCCACCGG GACCTGGCTG CCCGAAACGT GCTGGTGACC 
GAGGATGACG TGATGAAGAT CGCTGACTTT GGTCTGGCCC GTGGTGTCCA CCACATCGAC 
TACTATAAGA AAACCAGCAA TGGCCGCCTG CCAGTCAAGT GGATGGCTCC TGAGGCGTTG 
TTTGACCGTG TATACACACA CCAGAGTGAC GTGTGGTCCT TCGGGATCCT GCTGTGGGAA 
ATCTTCACCC TCGGGGGCTC CCCATACCCC GGCATCCCAG TGGAGGAGCT GTTCTCACTG 
CTGCGAGAGG GGCACAGGAT GGAGCGGCCC CCAAACTGCC CCTCAGAGCT GTATGGGCTA 
ATGAGGGAGT GTTGGCACGC AGCTCCTTCT CAGAGGCCGA CTTTTAAGCA GCTGGTGGAA 
GCTCTGGACA AGGTCCTGCT GGCTGTCTCT GAAGAGTACC TTGACCTCCG CCTGACCTTT 
GGACCCTATT CCCCCAACAA TGGGGATGCC AGCAGCACGT GCTCCTCCAG CGACTCGGTT 
TTCAGCCACG ACCCTTTGCC CCTCGAGCCA AGCCCCTTCC CATTTCCTGA GGCGCAGACC 
ACATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006253668.1
CDS	194..2599
Translation	MWLLLALLSIFQETPAFSLEASEEMEQEPCPAPISEQQEQVLTVALGQPVRLCCGRTERGRHWYKEGSRLASAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMTVVHNLTLIMDDSLPSINNEDPKTLSSSSSGHSYLQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPMPTIHWLKNGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENSLGSIRYSYLLDVLERSPHRPILQAGLPANTTAVVGSNVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTTDINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEAEEEDLAWTTATSEARYTDIILYVSGSLALVLLLLLAGVYHRQAIHGHHSRQPVTVQKLSRFPLARQFSLESRSSGKSSLSLVRGVRLSSSGPPLLTGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEALGMDSSRPDQTSTVAVKMLKDNASDKDLADLISEMEMMKLIGRHKNIINLLGVCTQEGPLYVIVEYAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPALVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDDVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMERPPNCPSELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPNNGDASSTCSSSDSVFSHDPLPLEPSPFPFPEAQTT

Target ORF information:

RefSeq Version	XM_006253606.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus fibroblast growth factor receptor 4 (Fgfr4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006253606.3

ORF Insert Sequence:

ATGTGGCTGC TGTTGGCTTT GTTGAGCATC TTTCAGGAGA CACCAGCCTT CTCCCTTGAG 
GCCTCTGAGG AAATGGAACA GGAGCCCTGC CCAGCCCCAA TCTCGGAGCA GCAAGAGCAG 
GTGTTGACTG TGGCCCTTGG GCAGCCTGTG CGGCTATGCT GTGGCCGCAC TGAGCGTGGT 
CGTCATTGGT ACAAGGAGGG CAGCCGTTTA GCATCTGCTG GGAGAGTACG GGGCTGGAGA 
GGCCGCCTGG AGATCGCCAG CTTCCTTCCT GAGGATGCTG GCCGGTACCT CTGCCTGGCC 
CGTGGCTCCA TGACTGTCGT ACACAATCTT ACTTTGATTA TGGATGACTC CTTACCCTCC 
ATCAATAACG AGGACCCCAA GACCCTCAGC AGCTCCTCGA GTGGGCACTC CTACCTGCAG 
CAAGCACCTT ACTGGACACA CCCCCAACGC ATGGAGAAGA AACTGCACGC GGTACCTGCC 
GGGAACACTG TCAAATTCCG CTGTCCAGCT GCAGGGAACC CCATGCCCAC CATCCACTGG 
CTCAAGAACG GACAGGCCTT CCACGGAGAG AATCGTATCG GAGGCATTCG GCTGCGTCAC 
CAACACTGGA GCCTCGTGAT GGAGAGCGTG GTGCCCTCAG ACCGTGGCAC GTACACGTGT 
CTTGTGGAGA ACTCTCTGGG TAGCATTCGC TACAGCTATC TGCTGGATGT GCTGGAGCGG 
TCCCCGCACC GGCCCATCCT GCAGGCGGGA CTCCCAGCCA ACACCACGGC TGTGGTTGGC 
AGCAACGTGG AGCTGCTGTG CAAGGTGTAC AGTGACGCCC AGCCGCACAT CCAGTGGCTG 
AAGCACATCG TTATCAACGG CAGCAGTTTC GGCGCTGATG GTTTCCCCTA CGTACAAGTC 
CTGAAGACAA CAGACATCAA TAGCTCAGAG GTGGAGGTGC TGTATCTGAG GAACGTGTCG 
GCTGAGGATG CAGGGGAGTA CACCTGCCTG GCGGGCAACT CCATCGGCCT CTCCTACCAG 
TCAGCGTGGC TCACAGTGCT ACCCGAAGCA GAGGAAGAAG ACCTCGCGTG GACAACAGCA 
ACATCGGAGG CCAGATATAC AGATATTATC CTATATGTAT CTGGCTCACT GGCTTTGGTT 
TTGCTCCTGC TGCTGGCCGG GGTGTATCAC CGACAAGCAA TCCACGGCCA CCACTCTCGA 
CAGCCTGTCA CTGTACAGAA GCTGTCCCGG TTCCCTTTGG CCCGGCAGTT CTCCTTGGAG 
TCGAGGTCCT CTGGCAAGTC AAGTTTGTCC CTGGTGCGAG GTGTCCGGCT CTCCTCCAGT 
GGCCCGCCCT TGCTCACGGG CCTTGTGAGT CTAGACCTAC CTCTCGATCC ACTTTGGGAG 
TTCCCCCGGG ACAGGCTGGT GCTCGGAAAG CCCCTGGGTG AGGGCTGCTT TGGGCAAGTG 
GTTCGTGCAG AAGCCCTTGG CATGGATTCC TCCCGGCCAG ACCAAACCAG CACCGTGGCT 
GTGAAGATGC TGAAAGACAA TGCCTCCGAC AAGGATTTGG CAGACCTGAT CTCTGAGATG 
GAGATGATGA AGCTAATCGG AAGACACAAG AACATCATTA ACCTGCTGGG TGTCTGCACT 
CAGGAAGGGC CCCTGTATGT GATTGTGGAA TATGCGGCCA AGGGAAACCT TCGGGAATTC 
CTCCGTGCCC GGCGTCCCCC AGGCCCTGAT CTCAGCCCTG ATGGGCCTCG GAGCAGCGAA 
GGACCGCTCT CCTTCCCGGC CCTGGTCTCC TGTGCCTACC AGGTGGCCCG AGGCATGCAG 
TATCTGGAGT CTCGGAAGTG CATCCACCGG GACCTGGCTG CCCGAAACGT GCTGGTGACC 
GAGGATGACG TGATGAAGAT CGCTGACTTT GGTCTGGCCC GTGGTGTCCA CCACATCGAC 
TACTATAAGA AAACCAGCAA TGGCCGCCTG CCAGTCAAGT GGATGGCTCC TGAGGCGTTG 
TTTGACCGTG TATACACACA CCAGAGTGAC GTGTGGTCCT TCGGGATCCT GCTGTGGGAA 
ATCTTCACCC TCGGGGGCTC CCCATACCCC GGCATCCCAG TGGAGGAGCT GTTCTCACTG 
CTGCGAGAGG GGCACAGGAT GGAGCGGCCC CCAAACTGCC CCTCAGAGCT GTATGGGCTA 
ATGAGGGAGT GTTGGCACGC AGCTCCTTCT CAGAGGCCGA CTTTTAAGCA GCTGGTGGAA 
GCTCTGGACA AGGTCCTGCT GGCTGTCTCT GAAGAGTACC TTGACCTCCG CCTGACCTTT 
GGACCCTATT CCCCCAACAA TGGGGATGCC AGCAGCACGT GCTCCTCCAG CGACTCGGTT 
TTCAGCCACG ACCCTTTGCC CCTCGAGCCA AGCCCCTTCC CATTTCCTGA GGCGCAGACC 
ACATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Vitamin D treatment attenuates cardiac FGF23/FGFR4 signaling and hypertrophy in uremic rats.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association32(9)1493-1503(2017 Sep)
Leifheit-Nestler M,Grabner A,Hermann L,Richter B,Schmitz K,Fischer DC,Yanucil C,Faul C,Haffner D

Regulation of renal phosphate transport by FGF23 is mediated by FGFR1 and FGFR4.
American journal of physiology. Renal physiology306(3)F351-8(2014 Feb)
Gattineni J,Alphonse P,Zhang Q,Mathews N,Bates CM,Baum M

Regulation of serum 1,25(OH)2 vitamin D3 levels by fibroblast growth factor 23 is mediated by FGF receptors 3 and 4.
American journal of physiology. Renal physiology301(2)F371-7(2011 Aug)
Gattineni J,Twombley K,Goetz R,Mohammadi M,Baum M

Fibroblast growth factor receptor 4 regulates tumor invasion by coupling fibroblast growth factor signaling to extracellular matrix degradation.
Cancer research70(20)7851-61(2010 Oct)
Sugiyama N,Varjosalo M,Meller P,Lohi J,Hyytiäinen M,Kilpinen S,Kallioniemi O,Ingvarsen S,Engelholm LH,Taipale J,Alitalo K,Keski-Oja J,Lehti K

FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4.
Cytokine11(10)729-35(1999 Oct)
Xie MH,Holcomb I,Deuel B,Dowd P,Huang A,Vagts A,Foster J,Liang J,Brush J,Gu Q,Hillan K,Goddard A,Gurney AL

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Fgfr4 cDNA ORF clone, Rattus norvegicus(Norway rat)

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