fgfr4 cDNA ORF clone, Danio rerio(zebrafish)

Gene
Clones
gRNAs

Summary

Gene Symbol	fgfr4
Entrez Gene ID	100000160
Full Name	fibroblast growth factor receptor 4
Synonyms	etID309818.21,wu:fc13h10,zgc:111935
General protein information	Preferred Names fibroblast growth factor receptor 4 Names fibroblast growth factor receptor 4 FGFR-4
Gene Type	protein-coding
Organism	Danio rerio(zebrafish)

mRNA and Protein(s)

mRNA	Protein	Name
NM_131430.1	NP_571505.1	fibroblast growth factor receptor 4 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	FGFR4	NP_002002.3
Canis lupus familiaris (dog)	FGFR4	XP_005619229.1
Gallus gallus (chicken)	FGFR4	XP_003642120.2
Pan troglodytes (chimpanzee)	FGFR4	XP_518127.4
Bos taurus (cattle)	FGFR4	NP_001179513.1
Mus musculus (house mouse)	Fgfr4	NP_032037.2
Rattus norvegicus (Norway rat)	Fgfr4	NP_001103374.1
Xenopus tropicalis (tropical clawed frog)	fgfr4	NP_001016323.1
Macaca mulatta (Rhesus monkey)	FGFR4	XP_001087243.1
Danio rerio (zebrafish)	fgfr4	NP_571505.1

Gene Ontology
Bibliography

Related articles in PubMed

Active receptor tyrosine kinases, but not Brachyury, are sufficient to trigger chordoma in zebrafish.
D'Agati G, Cabello EM, Frontzek K, Rushing EJ, Klemm R, Robinson MD, White RM, Mosimann C, Burger A
Disease models & mechanisms12(7)(2019 07)

Maternal Ybx1 safeguards zebrafish oocyte maturation and maternal-to-zygotic transition by repressing global translation.
Sun J, Yan L, Shen W, Meng A
Development (Cambridge, England)145(19)(2018 10)

Opposing Actions of Fgf8a on Notch Signaling Distinguish Two Muller Glial Cell Populations that Contribute to Retina Growth and Regeneration.
Wan J, Goldman D
Cell reports19(4)849-862(2017 04)

Bmp signaling mediates endoderm pouch morphogenesis by regulating Fgf signaling in zebrafish.
Lovely CB, Swartz ME, McCarthy N, Norrie JL, Eberhart JK
Development (Cambridge, England)143(11)2000-11(2016 06)

Deguelin-induced blockade of PI3K/protein kinase B/MAP kinase signaling in zebrafish and breast cancer cell lines is mediated by down-regulation of fibroblast growth factor receptor 4 activity.
Wu W, Hai Y, Chen L, Liu RJ, Han YX, Li WH, Li S, Lin S, Wu XR
Pharmacology research & perspectives4(2)e00212(2016 04)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following fgfr4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the fgfr4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ODa00346	NM_131430.1 Latest version!	Danio rerio fibroblast growth factor receptor 4 (fgfr4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

fgfr4 ( NM_131430.1 ) cDNA ORF clone, Danio rerio(zebrafish) -> NP_571505.1 Danio rerio fibroblast growth factor receptor 4 (fgfr4), mRNA.

Price & Availability↑

CloneID	ODa00346
Clone ID Related Accession (Same CDS sequence)	NM_131430.1
Accession Version	NM_131430.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2769bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577116800000
Organism	Danio rerio(zebrafish)
Product	fibroblast growth factor receptor 4 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U23839.1. On or before Nov 27, 2007 this sequence version replaced XM_001336122.1, XM_001336275.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U23839.1, BC171704.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2168446, SAMEA2168447 [ECO:0000350] ##Evidence-Data-END##

ATGTTGAGCA TCTTAAAGGT TTTCATTGCC ATCTGTTTCA TGGAACTGGT GTGCTCAAGA 
AGCATAACAT CCGGGGAACC CAGGGCAAAA GATATCAGAG TTTCACGACA CATACTTACT 
CCTGGATATC CTGAGAATGC TACTGTGTTG GTCGGAGGAC ATGTGAAGCT GGTGTGTAAG 
CTCCACCAGC CAGCCTCAAC ACGTCTCCAG TGGTTCAAGA AGGACAGTAA TCGCCTGGGG 
CCTGATGGAT CACCAGTACT TACAGCTCTT ACGCCTCTTC TTGAGAACCT CTCCAAAGTC 
AACATATTTC CTTTGGTTAA TATCTCTTTG GAAGATGCTG GAGAGTATGT ATGCAAGGCG 
GAAAACTCAG CTGGTCAGGC TACTCGCTCT GCCTGGGTGG AAGTCTTATC GGAAGTTTCA 
GAGGAGCCAA CTGAGGAACC ATCAGAGCAC CTGCTGTTGG AGCTCGGGGA TGTACTTAAA 
CTCCGTTGTG ACACAAACCG TCCTGGAGCT GTCCAGTGGT TCAAGAGTGG TGTTCGGGTG 
CAACACAATG CCCGTATCCA GATAAGAGCG GCAGTCATGG AAATTGCAGA TGTTACCTAT 
GAAGATTCAG GAGTATATGT GTGTATGCTA CGTGGCACCA AAGAGGCTCT ACGCAACTTC 
ACTATCACAG TGGCAGATGC TGTAGGGTCG GGAGATGATG ATGATGAAGA TAATGGTCTT 
GATGACATTG GTCCTGAGAC CGAAAATGAC CAGGTCTACA TATCCAGAGC ACCATACTGG 
ACTCACACTC AAAGGATGGA AAAGAAGCTG TATGCAGTCC CGGCTGGAAA TACTGTCAAG 
TTCCGCTGCC CTGCCACTGG GAGCCCTCTT CCCACCATTC GCTGGCTAAA AAATGGCAGA 
GAATTCCGAG GAGAGCACAG GATTGGTGGC ATCAAGCTAC GACATCAGCA CTGGAGCCTG 
GTCATGGAGA GTGTGGTTCC CTCAGACCGT GGGAATTACA GTTGTGTGGT GGAGAACAAA 
TATGGATCCA TCGCTCACAC CTACCTCTTG GACGTGTTGG AACGCTCTCC ACACAGGCCA 
ATTCTTCAAG CTGGTCTCCC CAAAAACACT ACAGCTATAG TGGGTGGAGA TGCCCAGTTC 
CTGTGTAAAG TGTACAGTGA TGCTCAGCCT CACATCCAGT GGCTCAAGCA TATAGAAATG 
AATGGCAGCC GTTATGGGCC TGATGGCATT CCTTATGTGA AGATTGTGAA GACAGGAAGC 
TTGAACATGT CTGAAGTTGA AGTCTTGTAT CTTACCAATA TCTCAATGGA GGATGCTGGA 
GAATACTCCT GCTTGGCTGG AAACTCTATT GGTTTCTCTC ATCAATCTGC CTGGCTCACA 
GTCTTATCAG AGGAGGATGT AGCCAAGGAG GTGGACCTAA TGGAGGCCAA ATACACTGAC 
ATCATCATCT ATGCTTCTGG CTTTTTGGCA CTGGTGATGG CCATTGTGAT TGTGGTCCTC 
TGCCGCATGC AGGTTCACCC CAGTCGGGAG CCTTTTGATA CGCTCCCAGT ACAGAAACTC 
TCCAAATTTC CTTTGCGCAG ACAGTATTCA GTGGAGTCCA ATTCTTCTGG AAAATCAAGT 
GCGTCACTGA TGAGGGTGGC TCGTCTTTCC TCCAGTTGTT CCCCAATGCT GGCTGGAGTT 
ATGGAGTTTG AACTGCCTTA TGACCCTGAT TGGGAGTTTC CAAGAGAGAA TTTGACTTTA 
GGGAAACCGC TTGGAGAGGG TTGCTTTGGT CAAGTGGTTA GAGCAGAGGC GTATGGGATA 
AACAAAGAGA ATCAAGATCA TATGGCAACT GTAGCTGTTA AAATGCTAAA AGATGATGCA 
ACCGATAAAG ACCTTGCAGA CCTGATCTCT GAGATGGAGC TCATGAAGGT TATGGACAAG 
CACAAGAACA TCATAAATCT TCTTGGTGTT TGTACACAGG ACGGTCCGCT GTACGTACTG 
GTTGAATATG CATCAAAAGG TAGCCTACGG GAATATCTCC GAGCTCGTCG ACCTCCTGGC 
ATGGACTACA CCTTTGATGT GACCAAGGTT CCTGAGGAAC AGCTCACCTT CAAAGACCTG 
GTTTCTTGTG CTTACCAAGT GGCAAGAGGC ATGGAGTACC TGGCTTCCAA AAGATGCATT 
CACAGAGATT TAGCCGCAAG AAATGTTCTT GTGACAGAAG ACAATGTGAT GAAGATCGCA 
GACTTTGGCT TGGCAAGAGG AGTGCATCAA ATTGATTACT ACAAGAAGAC AACTAATGGA 
CGTATGCCAG TGAAATGGAT GGCACCAGAA GCCTTGTTTG ACAGAGTCTA CACACACCAG 
AGCGACGTAT GGTCTTTCGG GGTTTTGATG TGGGAGATAT TCACATTGGG AGGATCTCCG 
TACCCTGGGA TACCAGTAGA GGAGCTTTTT AAGCTGCTGA AGGAAGGCCA TCGGATGGAT 
AAACCCTCCA ACTGCACCCA TGAACTCTAC ATGAAGATGA GAGAGTGCTG GCATGCAGTA 
CCAACTCAAA GACCAACGTT CAAACAACTT GTGGAAGAGC TCGATAGGGT GCTGGTGTCA 
ATTTCAGATG AGTACCTGGA CCTATCCACC CCTTTCGAAC AGTACTCTCC ATCTTGTGAG 
GACACCTCCA GCTCATGCTC TTCAGACAAT GATTCTGTGT TTACCCATGA TGCTTTGTCA 
ACCGAACCAT GCCTCCTTGG CTACCACGAT GTGCATTCTC GGATGGACCT AAAGACGACA 
ATGCGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_571505.1
CDS	403..3171
Translation	MLSILKVFIAICFMELVCSRSITSGEPRAKDIRVSRHILTPGYPENATVLVGGHVKLVCKLHQPASTRLQWFKKDSNRLGPDGSPVLTALTPLLENLSKVNIFPLVNISLEDAGEYVCKAENSAGQATRSAWVEVLSEVSEEPTEEPSEHLLLELGDVLKLRCDTNRPGAVQWFKSGVRVQHNARIQIRAAVMEIADVTYEDSGVYVCMLRGTKEALRNFTITVADAVGSGDDDDEDNGLDDIGPETENDQVYISRAPYWTHTQRMEKKLYAVPAGNTVKFRCPATGSPLPTIRWLKNGREFRGEHRIGGIKLRHQHWSLVMESVVPSDRGNYSCVVENKYGSIAHTYLLDVLERSPHRPILQAGLPKNTTAIVGGDAQFLCKVYSDAQPHIQWLKHIEMNGSRYGPDGIPYVKIVKTGSLNMSEVEVLYLTNISMEDAGEYSCLAGNSIGFSHQSAWLTVLSEEDVAKEVDLMEAKYTDIIIYASGFLALVMAIVIVVLCRMQVHPSREPFDTLPVQKLSKFPLRRQYSVESNSSGKSSASLMRVARLSSSCSPMLAGVMEFELPYDPDWEFPRENLTLGKPLGEGCFGQVVRAEAYGINKENQDHMATVAVKMLKDDATDKDLADLISEMELMKVMDKHKNIINLLGVCTQDGPLYVLVEYASKGSLREYLRARRPPGMDYTFDVTKVPEEQLTFKDLVSCAYQVARGMEYLASKRCIHRDLAARNVLVTEDNVMKIADFGLARGVHQIDYYKKTTNGRMPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPSNCTHELYMKMRECWHAVPTQRPTFKQLVEELDRVLVSISDEYLDLSTPFEQYSPSCEDTSSSCSSDNDSVFTHDALSTEPCLLGYHDVHSRMDLKTTMR

Target ORF information:

RefSeq Version	NM_131430.1
Organism	Danio rerio(zebrafish)
Definition	Danio rerio fibroblast growth factor receptor 4 (fgfr4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_131430.1

ORF Insert Sequence:

ATGTTGAGCA TCTTAAAGGT TTTCATTGCC ATCTGTTTCA TGGAACTGGT GTGCTCAAGA 
AGCATAACAT CCGGGGAACC CAGGGCAAAA GATATCAGAG TTTCACGACA CATACTTACT 
CCTGGATATC CTGAGAATGC TACTGTGTTG GTCGGAGGAC ATGTGAAGCT GGTGTGTAAG 
CTCCACCAGC CAGCCTCAAC ACGTCTCCAG TGGTTCAAGA AGGACAGTAA TCGCCTGGGG 
CCTGATGGAT CACCAGTACT TACAGCTCTT ACGCCTCTTC TTGAGAACCT CTCCAAAGTC 
AACATATTTC CTTTGGTTAA TATCTCTTTG GAAGATGCTG GAGAGTATGT ATGCAAGGCG 
GAAAACTCAG CTGGTCAGGC TACTCGCTCT GCCTGGGTGG AAGTCTTATC GGAAGTTTCA 
GAGGAGCCAA CTGAGGAACC ATCAGAGCAC CTGCTGTTGG AGCTCGGGGA TGTACTTAAA 
CTCCGTTGTG ACACAAACCG TCCTGGAGCT GTCCAGTGGT TCAAGAGTGG TGTTCGGGTG 
CAACACAATG CCCGTATCCA GATAAGAGCG GCAGTCATGG AAATTGCAGA TGTTACCTAT 
GAAGATTCAG GAGTATATGT GTGTATGCTA CGTGGCACCA AAGAGGCTCT ACGCAACTTC 
ACTATCACAG TGGCAGATGC TGTAGGGTCG GGAGATGATG ATGATGAAGA TAATGGTCTT 
GATGACATTG GTCCTGAGAC CGAAAATGAC CAGGTCTACA TATCCAGAGC ACCATACTGG 
ACTCACACTC AAAGGATGGA AAAGAAGCTG TATGCAGTCC CGGCTGGAAA TACTGTCAAG 
TTCCGCTGCC CTGCCACTGG GAGCCCTCTT CCCACCATTC GCTGGCTAAA AAATGGCAGA 
GAATTCCGAG GAGAGCACAG GATTGGTGGC ATCAAGCTAC GACATCAGCA CTGGAGCCTG 
GTCATGGAGA GTGTGGTTCC CTCAGACCGT GGGAATTACA GTTGTGTGGT GGAGAACAAA 
TATGGATCCA TCGCTCACAC CTACCTCTTG GACGTGTTGG AACGCTCTCC ACACAGGCCA 
ATTCTTCAAG CTGGTCTCCC CAAAAACACT ACAGCTATAG TGGGTGGAGA TGCCCAGTTC 
CTGTGTAAAG TGTACAGTGA TGCTCAGCCT CACATCCAGT GGCTCAAGCA TATAGAAATG 
AATGGCAGCC GTTATGGGCC TGATGGCATT CCTTATGTGA AGATTGTGAA GACAGGAAGC 
TTGAACATGT CTGAAGTTGA AGTCTTGTAT CTTACCAATA TCTCAATGGA GGATGCTGGA 
GAATACTCCT GCTTGGCTGG AAACTCTATT GGTTTCTCTC ATCAATCTGC CTGGCTCACA 
GTCTTATCAG AGGAGGATGT AGCCAAGGAG GTGGACCTAA TGGAGGCCAA ATACACTGAC 
ATCATCATCT ATGCTTCTGG CTTTTTGGCA CTGGTGATGG CCATTGTGAT TGTGGTCCTC 
TGCCGCATGC AGGTTCACCC CAGTCGGGAG CCTTTTGATA CGCTCCCAGT ACAGAAACTC 
TCCAAATTTC CTTTGCGCAG ACAGTATTCA GTGGAGTCCA ATTCTTCTGG AAAATCAAGT 
GCGTCACTGA TGAGGGTGGC TCGTCTTTCC TCCAGTTGTT CCCCAATGCT GGCTGGAGTT 
ATGGAGTTTG AACTGCCTTA TGACCCTGAT TGGGAGTTTC CAAGAGAGAA TTTGACTTTA 
GGGAAACCGC TTGGAGAGGG TTGCTTTGGT CAAGTGGTTA GAGCAGAGGC GTATGGGATA 
AACAAAGAGA ATCAAGATCA TATGGCAACT GTAGCTGTTA AAATGCTAAA AGATGATGCA 
ACCGATAAAG ACCTTGCAGA CCTGATCTCT GAGATGGAGC TCATGAAGGT TATGGACAAG 
CACAAGAACA TCATAAATCT TCTTGGTGTT TGTACACAGG ACGGTCCGCT GTACGTACTG 
GTTGAATATG CATCAAAAGG TAGCCTACGG GAATATCTCC GAGCTCGTCG ACCTCCTGGC 
ATGGACTACA CCTTTGATGT GACCAAGGTT CCTGAGGAAC AGCTCACCTT CAAAGACCTG 
GTTTCTTGTG CTTACCAAGT GGCAAGAGGC ATGGAGTACC TGGCTTCCAA AAGATGCATT 
CACAGAGATT TAGCCGCAAG AAATGTTCTT GTGACAGAAG ACAATGTGAT GAAGATCGCA 
GACTTTGGCT TGGCAAGAGG AGTGCATCAA ATTGATTACT ACAAGAAGAC AACTAATGGA 
CGTATGCCAG TGAAATGGAT GGCACCAGAA GCCTTGTTTG ACAGAGTCTA CACACACCAG 
AGCGACGTAT GGTCTTTCGG GGTTTTGATG TGGGAGATAT TCACATTGGG AGGATCTCCG 
TACCCTGGGA TACCAGTAGA GGAGCTTTTT AAGCTGCTGA AGGAAGGCCA TCGGATGGAT 
AAACCCTCCA ACTGCACCCA TGAACTCTAC ATGAAGATGA GAGAGTGCTG GCATGCAGTA 
CCAACTCAAA GACCAACGTT CAAACAACTT GTGGAAGAGC TCGATAGGGT GCTGGTGTCA 
ATTTCAGATG AGTACCTGGA CCTATCCACC CCTTTCGAAC AGTACTCTCC ATCTTGTGAG 
GACACCTCCA GCTCATGCTC TTCAGACAAT GATTCTGTGT TTACCCATGA TGCTTTGTCA 
ACCGAACCAT GCCTCCTTGG CTACCACGAT GTGCATTCTC GGATGGACCT AAAGACGACA 
ATGCGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Active receptor tyrosine kinases, but not Brachyury, are sufficient to trigger chordoma in zebrafish.
Disease models & mechanisms12(7)(2019 07)
D'Agati G,Cabello EM,Frontzek K,Rushing EJ,Klemm R,Robinson MD,White RM,Mosimann C,Burger A

Maternal Ybx1 safeguards zebrafish oocyte maturation and maternal-to-zygotic transition by repressing global translation.
Development (Cambridge, England)145(19)(2018 10)
Sun J,Yan L,Shen W,Meng A

Opposing Actions of Fgf8a on Notch Signaling Distinguish Two Muller Glial Cell Populations that Contribute to Retina Growth and Regeneration.
Cell reports19(4)849-862(2017 04)
Wan J,Goldman D

Bmp signaling mediates endoderm pouch morphogenesis by regulating Fgf signaling in zebrafish.
Development (Cambridge, England)143(11)2000-11(2016 06)
Lovely CB,Swartz ME,McCarthy N,Norrie JL,Eberhart JK

Deguelin-induced blockade of PI3K/protein kinase B/MAP kinase signaling in zebrafish and breast cancer cell lines is mediated by down-regulation of fibroblast growth factor receptor 4 activity.
Pharmacology research & perspectives4(2)e00212(2016 04)
Wu W,Hai Y,Chen L,Liu RJ,Han YX,Li WH,Li S,Lin S,Wu XR

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fgfr4 cDNA ORF clone, Danio rerio(zebrafish)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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