Jak2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Jak2
Entrez Gene ID	24514
Full Name	Janus kinase 2
General protein information	Preferred Names Janus kinase 2 Names tyrosine-protein kinase JAK2 JAK-2 Janus kinase 2 (a protein tyrosine kinase)
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q52
Summary	associated with receptors for erythropoietin, prolactin, growth hormones and interleukin-3; phosphorylated when activated by cytokines [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031514.1	NP_113702.1	tyrosine-protein kinase JAK2

Pathways from BioSystems

Homologies

Macaca mulatta (Rhesus monkey)	JAK2	XP_001082883.1
Gallus gallus (chicken)	JAK2	NP_001025709.1
Pan troglodytes (chimpanzee)	JAK2	XP_001139368.1
Danio rerio (zebrafish)	jak2b	NP_571162.1
Canis lupus familiaris (dog)	JAK2	XP_541301.2
Bos taurus (cattle)	JAK2	XP_003586433.1
Mus musculus (house mouse)	Jak2	NP_032439.2
Xenopus tropicalis (tropical clawed frog)	jak2	NP_001090634.1
Homo sapiens (human)	JAK2	NP_004963.1
Rattus norvegicus (Norway rat)	Jak2	NP_113702.1

Gene Ontology
Bibliography

Related articles in PubMed

Knock-down of JAK2 and PTEN on pain behavior in rat model of trigeminal neuropathic pain.
Li L, Yao L, Wang F, Zhang Z
Gene719144080(2019 Nov)

Electroacupuncture Regulates Hippocampal Synaptic Plasticity via Inhibiting Janus-Activated Kinase 2/Signal Transducer and Activator of Transcription 3 Signaling in Cerebral Ischemic Rats.
Xie G, Song C, Lin X, Yang M, Fan X, Liu W, Tao J, Chen L, Huang J
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association28(3)792-799(2019 Mar)

PPARγ alleviated hepatocyte steatosis through reducing SOCS3 by inhibiting JAK2/STAT3 pathway.
Bi J, Sun K, Wu H, Chen X, Tang H, Mao J
Biochemical and biophysical research communications498(4)1037-1044(2018 04)

DUSP19 regulates IL-1β-induced apoptosis and MMPs expression in rat chondrocytes through JAK2/STAT3 signaling pathway.
Yao ZZ, Hu AX, Liu XS
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie961209-1215(2017 Dec)

Inhibition of JAK2 Signaling Alleviates Hyperlipidemia-Intensified Caerulin-Induced Acute Pancreatitis In Vivo.
Zhu F, Guan Y, Zhang R
Current molecular medicine17(5)381-387(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Jak2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Jak2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13063	NM_031514.1 Latest version!	Rattus norvegicus Janus kinase 2 (Jak2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$559.30 $799.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Jak2 ( NM_031514.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_113702.1 Rattus norvegicus Janus kinase 2 (Jak2), mRNA.

Price & Availability↑

CloneID	ORa13063
Clone ID Related Accession (Same CDS sequence)	NM_031514.1
Accession Version	NM_031514.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3399bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577289600000
Organism	Rattus norvegicus(Norway rat)
Product	tyrosine-protein kinase JAK2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U13396.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U13396.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGGAATGG CTTGCCTTAC AATGACAGAA ATGGAGGGAA CCTCCACATC TCCTGCACAT 
CAGAATGGTG ATATTCCTGG AAATGCTAAC TCTGTGAAGC AGACAGAGCC AGTCCTTCAA 
GTGTACCTGT ACCATTCTCT TGGGCAAGCT GAAGGAGACT ATCTGAAGTT TCCAAATGGA 
GAGTATGTTG CCGAAGAAAT TTGTGTGGCT GCTTCTAAAG CATGTGGTAT TACGCCTGTG 
TATCATAATA TGTTTGCTTT AATGAGTGAA ACAGAAAGGA TCTGGTATCC ACCCAATCAT 
GTCTTCCACA TAGATGAGTC AACCAGGCAT AATATACTCT ACAGAATAAG GTTTTACTTT 
CCTCATTGGT ACTGCAGTGG CAGCAACAGA ACCTATAGGT ACGGAGTATC TCGTGGGGCT 
GAAGCTCCTC TCCTTGACGA CTTTGTCATG TCTTACCTTT TTGCTCAGTG GCGGCATGAT 
TTTGTTCATG GGTGGATAAA AGTACCTGTG ACTCACGAAA CTCAGGAAGA ATGTCTTGGC 
ATGGCAGTGT TAGACATGAT GAGAATAGCT AAGGAGAAGG ACCAGACTCC CCTGGCTGTC 
TATAACTCCA TCAGCTACAA GACGTTCTTA CCGAAGTGCG TGCGAGCGAA GATCCAGGAC 
TATCACATTT TAACTCGGAA GCGGATAAGG TACAGATTCC GCAGGTTCAT TCAGCAGTTC 
AGTCAGTGCA AAGCCACTGC CAGGAACCTA AAACTTAAGT ATCTCATAAA CCTGGAGACC 
CTGCAGTCTG CCTTCTACAC AGAACAGTTT GAAGTAAAAG AATCTGCAAG AGGTCCTTCA 
GGTGAGGAGA TTTTTGCAAC CATTATAATA ACTGGAAACG GTGGAATTCA GTGGTCAAGA 
GGGAAACATA AGGAAAGTGA GACACTGACA GAACAGGATT TACAGTTGTA TTGTGATTTT 
CCTGATATTA TTGATGTCAG TATTAAGCAA GCAAATCAGG AATGCTCAAC TGAAAGTAGA 
GTTGTGACCG TCCACAAGCA GGACGGGAAG GTCTTGGAAA TAGAACTTAG CTCATTAAAA 
GAAGCCTTGT CATTTGTGTC GTTAATTGAC GGGTATTACA GACTAACTGC GGATGCACAC 
CATTACCTCT GTAAAGAGGT GGCTCCTCCA GCCGTGCTTG AAAACATACA CAGCAACTGT 
CACGGCCCAA TTTCAATGGA TTTTGCCATC AGCAAACTAA AGAAGGCAGG AAACCAGACT 
GGACTGTATG TACTTCGATG TAGCCCTAAG GACTTCAACA AATACTTCCT GACCTTTGCC 
GTTGAGCGAG AAAATGTTAT TGAATATAAA CACTGTTTGA TTACAAAGAA TGAGAATGGA 
GAGTACAACC TCAGTGGGAC TAAGAGGAAC TTCAGTAGTC TTAAGGACCT TTTGAATTGC 
TACCAGATGG AAACTGTGCG CTCAGACAGT ATCATCTTCC AGTTCACCAA ATGCTGTCCT 
CCAAAGCCGA AAGATAAATC AAACCTTCTT GTCTTCAGAA CAAATGGTGT TTCTGATGTT 
CAGCTCTCAC CAACATTACA GAGGCATAAT AATGTGAATC AAATGGTGTT TCACAAAATC 
AGGAATGAAG ATTTGATATT TAATGAAAGC CTTGGCCAAG GCACTTTTAC AAAAATATTT 
AAAGGTGTAA GAAGAGAAGT TGGAGATTAT GGTCAGCTGC ACGAAACCGA AGTTCTTTTG 
AAAGTCCTAG ATAAAGCACA TAGAAACTAT TCAGAGTCTT TCTTTGAAGC AGCAAGCATG 
ATGAGTCAGC TTTCTCACAA GCATTTGGTT TTGAATTATG GAGTATGTGT CTGTGGAGAG 
GAGAACATTT TGGTTCAAGA GTTTGTAAAA TTTGGATCCC TGGATACATA CCTGAAAAAA 
AACAAAAATT CCATAAATAT ACTATGGAAA CTTGGAGTGG CCAAACAGTT GGCATGGGCC 
ATGCACTTCC TCGAAGAAAA ATCCCTTATT CATGGGAATG TGTGTGCCAA AAATATCCTG 
CTTATCAGAG AAGAAGACAG GAAAACAGGG AATCCACCTT TCATCAAACT TAGTGATCCT 
GGGATTAGCA TCACAGTTCT ACCAAAGGAC ATTCTTCAGG AGAGAATACC ATGGGTACCA 
CCTGAGTGCA TTGAAAACCC TAAAAATCTA ACTTTGGCAA CAGACAAGTG GAGCTTTGGC 
ACCACTCTGT GGGAGATCTG CAGTGGAGGA GACAAGCCTC TGAGTGCTCT GGACTCTCAA 
AGAAAGCTGC AGTTCTATGA AGATAAGCAC CAGCTCCCAG CACCCAAGTG GACAGAGTTG 
GCAAACCTTA TAAATACTTG CATGGATTAT GAGCCAGACT TCAGGCCTGC CTTCAGAGCT 
GTCATCCGTG ATCTGAACAG CCTGTTTACT CCAGATTATG AACTGCTGAC AGAAAATGAC 
ATGCTACCCA ACATGAGAAT AGGTGCCCTA GGATTTTCTG GTGCTTTTGA AGACAGGGAC 
CCTACACAGT TTGAAGAGAG ACACTTGAAA TTTCTACAGC AACTTGGCAA GGGTAACTTT 
GGGAGTGTGG AGATGTGCCG CTATGACCCG CTGCAGGACA ACACTGGAGA GGTGGTAGCT 
GTTAAGAAGC TCCAGCACAG CACGGAAGAG CATCTCCGAG ACTTTGAAAG GGAAATTGAA 
ATCCTGAAAT CCTTGCAGCA TGACAACATC GTGAAGTACA AGGGAGTGTG CTACAGTGCT 
GGTCGGCGCA ACCTAAGATT AATTATGGAA TATTTGCCGT ATGGAAGTTT ACGAGACTAT 
CTCCAAAAAC ATAAAGAACG GATAGATCAC AAAAAACTTC TGCAGTATAC ATCCCAGATA 
TGCAAGGGCA TGGAGTATCT TGGTACAAAA AGGTATATCC ACCGGGATCT GGCAACAAGG 
AATATATTGG TAGAAAATGA GAACAGAGTT AAAATAGGAG ATTTTGGATT AACCAAAGTC 
TTGCCACAGG ACAAAGAATA CTACAAAGTA AAGGAACCAG GTGAAAGTCC CATATTCTGG 
TATGCTCCCG AATCCTTGAC AGAGAGCAAG TTTTCTGTGG CCTCAGATGT GTGGAGCTTT 
GGTGTGGTTC TGTACGAACT TTTCACGTAT ATCGAGAAGA GCAAAAGCCC ACCTGTGGAA 
TTTATGCGAA TGATCGGCAA TGATAAACAA GGGCAGATGA TCGTATTCCA TTTGATAGAG 
CTACTGAAGA ACAACGGAAG ACTGCCGAGA CCAGAAGGGT GCCCAGACGA GATTTATGTG 
ATCATGACAG AATGCTGGAA CAACAATGTC AACCAACGTC CCTCTTTCAG GGACCTTTCC 
CTTCGGGTGG ATCAAATCCG GGACAGTATG GCTGCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_113702.1
CDS	157..3555
Translation	MGMACLTMTEMEGTSTSPAHQNGDIPGNANSVKQTEPVLQVYLYHSLGQAEGDYLKFPNGEYVAEEICVAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNILYRIRFYFPHWYCSGSNRTYRYGVSRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKEKDQTPLAVYNSISYKTFLPKCVRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEQFEVKESARGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPDIIDVSIKQANQECSTESRVVTVHKQDGKVLEIELSSLKEALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIHSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENGEYNLSGTKRNFSSLKDLLNCYQMETVRSDSIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVQLSPTLQRHNNVNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSQLSHKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSINILWKLGVAKQLAWAMHFLEEKSLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLTLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDKHQLPAPKWTELANLINTCMDYEPDFRPAFRAVIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPVEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPEGCPDEIYVIMTECWNNNVNQRPSFRDLSLRVDQIRDSMAA

Target ORF information:

RefSeq Version	NM_031514.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus Janus kinase 2 (Jak2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031514.1

ORF Insert Sequence:

ATGGGAATGG CTTGCCTTAC AATGACAGAA ATGGAGGGAA CCTCCACATC TCCTGCACAT 
CAGAATGGTG ATATTCCTGG AAATGCTAAC TCTGTGAAGC AGACAGAGCC AGTCCTTCAA 
GTGTACCTGT ACCATTCTCT TGGGCAAGCT GAAGGAGACT ATCTGAAGTT TCCAAATGGA 
GAGTATGTTG CCGAAGAAAT TTGTGTGGCT GCTTCTAAAG CATGTGGTAT TACGCCTGTG 
TATCATAATA TGTTTGCTTT AATGAGTGAA ACAGAAAGGA TCTGGTATCC ACCCAATCAT 
GTCTTCCACA TAGATGAGTC AACCAGGCAT AATATACTCT ACAGAATAAG GTTTTACTTT 
CCTCATTGGT ACTGCAGTGG CAGCAACAGA ACCTATAGGT ACGGAGTATC TCGTGGGGCT 
GAAGCTCCTC TCCTTGACGA CTTTGTCATG TCTTACCTTT TTGCTCAGTG GCGGCATGAT 
TTTGTTCATG GGTGGATAAA AGTACCTGTG ACTCACGAAA CTCAGGAAGA ATGTCTTGGC 
ATGGCAGTGT TAGACATGAT GAGAATAGCT AAGGAGAAGG ACCAGACTCC CCTGGCTGTC 
TATAACTCCA TCAGCTACAA GACGTTCTTA CCGAAGTGCG TGCGAGCGAA GATCCAGGAC 
TATCACATTT TAACTCGGAA GCGGATAAGG TACAGATTCC GCAGGTTCAT TCAGCAGTTC 
AGTCAGTGCA AAGCCACTGC CAGGAACCTA AAACTTAAGT ATCTCATAAA CCTGGAGACC 
CTGCAGTCTG CCTTCTACAC AGAACAGTTT GAAGTAAAAG AATCTGCAAG AGGTCCTTCA 
GGTGAGGAGA TTTTTGCAAC CATTATAATA ACTGGAAACG GTGGAATTCA GTGGTCAAGA 
GGGAAACATA AGGAAAGTGA GACACTGACA GAACAGGATT TACAGTTGTA TTGTGATTTT 
CCTGATATTA TTGATGTCAG TATTAAGCAA GCAAATCAGG AATGCTCAAC TGAAAGTAGA 
GTTGTGACCG TCCACAAGCA GGACGGGAAG GTCTTGGAAA TAGAACTTAG CTCATTAAAA 
GAAGCCTTGT CATTTGTGTC GTTAATTGAC GGGTATTACA GACTAACTGC GGATGCACAC 
CATTACCTCT GTAAAGAGGT GGCTCCTCCA GCCGTGCTTG AAAACATACA CAGCAACTGT 
CACGGCCCAA TTTCAATGGA TTTTGCCATC AGCAAACTAA AGAAGGCAGG AAACCAGACT 
GGACTGTATG TACTTCGATG TAGCCCTAAG GACTTCAACA AATACTTCCT GACCTTTGCC 
GTTGAGCGAG AAAATGTTAT TGAATATAAA CACTGTTTGA TTACAAAGAA TGAGAATGGA 
GAGTACAACC TCAGTGGGAC TAAGAGGAAC TTCAGTAGTC TTAAGGACCT TTTGAATTGC 
TACCAGATGG AAACTGTGCG CTCAGACAGT ATCATCTTCC AGTTCACCAA ATGCTGTCCT 
CCAAAGCCGA AAGATAAATC AAACCTTCTT GTCTTCAGAA CAAATGGTGT TTCTGATGTT 
CAGCTCTCAC CAACATTACA GAGGCATAAT AATGTGAATC AAATGGTGTT TCACAAAATC 
AGGAATGAAG ATTTGATATT TAATGAAAGC CTTGGCCAAG GCACTTTTAC AAAAATATTT 
AAAGGTGTAA GAAGAGAAGT TGGAGATTAT GGTCAGCTGC ACGAAACCGA AGTTCTTTTG 
AAAGTCCTAG ATAAAGCACA TAGAAACTAT TCAGAGTCTT TCTTTGAAGC AGCAAGCATG 
ATGAGTCAGC TTTCTCACAA GCATTTGGTT TTGAATTATG GAGTATGTGT CTGTGGAGAG 
GAGAACATTT TGGTTCAAGA GTTTGTAAAA TTTGGATCCC TGGATACATA CCTGAAAAAA 
AACAAAAATT CCATAAATAT ACTATGGAAA CTTGGAGTGG CCAAACAGTT GGCATGGGCC 
ATGCACTTCC TCGAAGAAAA ATCCCTTATT CATGGGAATG TGTGTGCCAA AAATATCCTG 
CTTATCAGAG AAGAAGACAG GAAAACAGGG AATCCACCTT TCATCAAACT TAGTGATCCT 
GGGATTAGCA TCACAGTTCT ACCAAAGGAC ATTCTTCAGG AGAGAATACC ATGGGTACCA 
CCTGAGTGCA TTGAAAACCC TAAAAATCTA ACTTTGGCAA CAGACAAGTG GAGCTTTGGC 
ACCACTCTGT GGGAGATCTG CAGTGGAGGA GACAAGCCTC TGAGTGCTCT GGACTCTCAA 
AGAAAGCTGC AGTTCTATGA AGATAAGCAC CAGCTCCCAG CACCCAAGTG GACAGAGTTG 
GCAAACCTTA TAAATACTTG CATGGATTAT GAGCCAGACT TCAGGCCTGC CTTCAGAGCT 
GTCATCCGTG ATCTGAACAG CCTGTTTACT CCAGATTATG AACTGCTGAC AGAAAATGAC 
ATGCTACCCA ACATGAGAAT AGGTGCCCTA GGATTTTCTG GTGCTTTTGA AGACAGGGAC 
CCTACACAGT TTGAAGAGAG ACACTTGAAA TTTCTACAGC AACTTGGCAA GGGTAACTTT 
GGGAGTGTGG AGATGTGCCG CTATGACCCG CTGCAGGACA ACACTGGAGA GGTGGTAGCT 
GTTAAGAAGC TCCAGCACAG CACGGAAGAG CATCTCCGAG ACTTTGAAAG GGAAATTGAA 
ATCCTGAAAT CCTTGCAGCA TGACAACATC GTGAAGTACA AGGGAGTGTG CTACAGTGCT 
GGTCGGCGCA ACCTAAGATT AATTATGGAA TATTTGCCGT ATGGAAGTTT ACGAGACTAT 
CTCCAAAAAC ATAAAGAACG GATAGATCAC AAAAAACTTC TGCAGTATAC ATCCCAGATA 
TGCAAGGGCA TGGAGTATCT TGGTACAAAA AGGTATATCC ACCGGGATCT GGCAACAAGG 
AATATATTGG TAGAAAATGA GAACAGAGTT AAAATAGGAG ATTTTGGATT AACCAAAGTC 
TTGCCACAGG ACAAAGAATA CTACAAAGTA AAGGAACCAG GTGAAAGTCC CATATTCTGG 
TATGCTCCCG AATCCTTGAC AGAGAGCAAG TTTTCTGTGG CCTCAGATGT GTGGAGCTTT 
GGTGTGGTTC TGTACGAACT TTTCACGTAT ATCGAGAAGA GCAAAAGCCC ACCTGTGGAA 
TTTATGCGAA TGATCGGCAA TGATAAACAA GGGCAGATGA TCGTATTCCA TTTGATAGAG 
CTACTGAAGA ACAACGGAAG ACTGCCGAGA CCAGAAGGGT GCCCAGACGA GATTTATGTG 
ATCATGACAG AATGCTGGAA CAACAATGTC AACCAACGTC CCTCTTTCAG GGACCTTTCC 
CTTCGGGTGG ATCAAATCCG GGACAGTATG GCTGCATGA