Akr1b1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Akr1b1
Entrez Gene ID	24192
Full Name	aldo-keto reductase family 1 member B
Synonyms	ALDRED,ALR-P-I,Akr1b3,Akr1b4,Aldr1,Alr,RATALDRED
General protein information	Preferred Names aldo-keto reductase family 1 member B Names aldose reductase AR Aldehyde reductase 1 (low Km aldose reductase) (5.8 kb PstI fragment, probably the functional gene)
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q22
Summary	regulates NF-kappa B mediated mitogenic signaling; may play a role in the polyol pathway [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_012498.1	NP_036630.1	aldo-keto reductase family 1 member B1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	AKR1B1	NP_001012537.1
Rattus norvegicus (Norway rat)	Akr1b1	NP_036630.1
Pan troglodytes (chimpanzee)	AKR1B1	XP_001138232.2
Mus musculus (house mouse)	Akr1b3	NP_033788.3
Danio rerio (zebrafish)	akr1b1	NP_001002048.1
Homo sapiens (human)	AKR1B1	NP_001619.1
Macaca mulatta (Rhesus monkey)	AKR1B1	XP_001100679.1
Canis lupus familiaris (dog)	AKR1B1	NP_001239345.1
Danio rerio (zebrafish)	si:dkey-180p18.9	NP_001070715.1
Xenopus tropicalis (tropical clawed frog)	akr1b1	NP_001011130.1

Gene Ontology
Bibliography

Related articles in PubMed

AKR1B1 Upregulation Contributes to Neuroinflammation and Astrocytes Proliferation by Regulating the Energy Metabolism in Rat Spinal Cord Injury.
Chen X, Chen C, Hao J, Qin R, Qian B, Yang K, Zhang J, Zhang F
Neurochemical research43(8)1491-1499(2018 Aug)

Renoprotective Effects of Aldose Reductase Inhibitor Epalrestat against High Glucose-Induced Cellular Injury.
El Gamal H, Eid AH, Munusamy S
BioMed research international20175903105(2017)

A novel carboxymethylated mercaptotriazinoindole inhibitor of aldose reductase interferes with the polyol pathway in streptozotocin-induced diabetic rats.
Soltesova Prnova M, Ballekova J, Gajdosikova A, Gajdosik A, Stefek M
Physiological research64(4)587-91(2015)

Dual-color immunofluorescent labeling with quantum dots of the diabetes-associated proteins aldose reductase and Toll-like receptor 4 in the kidneys of diabetic rats.
Liu X, Hu R, Lian H, Liu Y, Liu J, Liu J, Lin G, Liu L, Duan X, Yong KT, Ye L
International journal of nanomedicine103651-62(2015)

Additive effect of aldose reductase Z-4 microsatellite polymorphism and glycaemic control on cataract development in type 2 diabetes.
Wang Y, Luk AO, Ng MC, Pang CC, Lam V, Lee SC, Lam DS, Choy KW, Ma RC, So WY, Chan JC
Journal of diabetes and its complications28(2)147-51(2014 Mar-Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Akr1b1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Akr1b1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12573	NM_012498.1 Latest version!	Rattus norvegicus aldo-keto reductase family 1 member B (Akr1b1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Akr1b1 ( NM_012498.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036630.1 Rattus norvegicus aldo-keto reductase family 1 member B (Akr1b1), mRNA.

Price & Availability↑

CloneID	ORa12573
Clone ID Related Accession (Same CDS sequence)	NM_012498.1
Accession Version	NM_012498.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 951bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577203200000
Organism	Rattus norvegicus(Norway rat)
Product	aldo-keto reductase family 1 member B1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M60322.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X05884.1, BC062034.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGCTAGCC ATCTGGAACT CAACAACGGC ACCAAGATGC CCACCCTGGG TCTGGGCACC 
TGGAAGTCTC CTCCTGGCCA GGTGACCGAG GCTGTGAAGG TTGCTATCGA CATGGGGTAT 
CGCCACATTG ACTGCGCCCA GGTGTACCAG AATGAGAAGG AGGTGGGGGT GGCCCTCCAG 
GAGAAGCTCA AGGAGCAGGT GGTGAAGCGC CAGGATCTCT TCATTGTCAG CAAGCTGTGG 
TGCACGTTCC ACGACCAGAG CATGGTGAAA GGGGCCTGCC AGAAGACGCT GAGCGACCTG 
CAGCTGGACT ACCTGGACCT CTACCTTATT CACTGGCCAA CTGGCTTCAA GCCTGGGCCT 
GACTATTTCC CCCTGGATGC ATCGGGAAAC GTGATTCCTA GTGACACCGA TTTTGTGGAC 
ACTTGGACGG CTATGGAGCA ACTAGTGGAT GAAGGTTTGG TAAAAGCAAT CGGAGTCTCC 
AACTTCAACC CTCTTCAGAT TGAGAGGATC TTGAACAAAC CTGGCTTAAA GTATAAGCCT 
GCTGTTAACC AGATCGAGTG CCACCCATAC CTAACTCAGG AGAAGCTGAT TGAGTACTGC 
CATTGCAAAG GCATCGTGGT GACTGCATAC AGTCCCCTTG GTTCTCCTGA CAGGCCCTGG 
GCCAAGCCTG AGGACCCCTC TCTCCTGGAG GATCCCAGGA TCAAGGAAAT TGCAGCCAAG 
TACAATAAAA CTACAGCCCA GGTGCTGATC CGGTTCCCCA TCCAAAGGAA CCTGGTCGTG 
ATCCCCAAGT CTGTGACACC AGCACGTATT GCTGAGAACT TTAAGGTCTT TGACTTTGAG 
CTGAGCAATG AGGACATGGC CACTCTACTC AGCTACAACA GGAACTGGAG GGTGTGCGCC 
TTGATGAGCT GTGCCAAACA CAAGGATTAC CCCTTCCACG CAGAAGTCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036630.1
CDS	39..989
Translation	MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQEKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKEIAAKYNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCALMSCAKHKDYPFHAEV

Target ORF information:

RefSeq Version	NM_012498.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus aldo-keto reductase family 1 member B (Akr1b1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012498.1

ORF Insert Sequence:

ATGGCTAGCC ATCTGGAACT CAACAACGGC ACCAAGATGC CCACCCTGGG TCTGGGCACC 
TGGAAGTCTC CTCCTGGCCA GGTGACCGAG GCTGTGAAGG TTGCTATCGA CATGGGGTAT 
CGCCACATTG ACTGCGCCCA GGTGTACCAG AATGAGAAGG AGGTGGGGGT GGCCCTCCAG 
GAGAAGCTCA AGGAGCAGGT GGTGAAGCGC CAGGATCTCT TCATTGTCAG CAAGCTGTGG 
TGCACGTTCC ACGACCAGAG CATGGTGAAA GGGGCCTGCC AGAAGACGCT GAGCGACCTG 
CAGCTGGACT ACCTGGACCT CTACCTTATT CACTGGCCAA CTGGCTTCAA GCCTGGGCCT 
GACTATTTCC CCCTGGATGC ATCGGGAAAC GTGATTCCTA GTGACACCGA TTTTGTGGAC 
ACTTGGACGG CTATGGAGCA ACTAGTGGAT GAAGGTTTGG TAAAAGCAAT CGGAGTCTCC 
AACTTCAACC CTCTTCAGAT TGAGAGGATC TTGAACAAAC CTGGCTTAAA GTATAAGCCT 
GCTGTTAACC AGATCGAGTG CCACCCATAC CTAACTCAGG AGAAGCTGAT TGAGTACTGC 
CATTGCAAAG GCATCGTGGT GACTGCATAC AGTCCCCTTG GTTCTCCTGA CAGGCCCTGG 
GCCAAGCCTG AGGACCCCTC TCTCCTGGAG GATCCCAGGA TCAAGGAAAT TGCAGCCAAG 
TACAATAAAA CTACAGCCCA GGTGCTGATC CGGTTCCCCA TCCAAAGGAA CCTGGTCGTG 
ATCCCCAAGT CTGTGACACC AGCACGTATT GCTGAGAACT TTAAGGTCTT TGACTTTGAG 
CTGAGCAATG AGGACATGGC CACTCTACTC AGCTACAACA GGAACTGGAG GGTGTGCGCC 
TTGATGAGCT GTGCCAAACA CAAGGATTAC CCCTTCCACG CAGAAGTCTG A