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About the Class A/1 (Rhodopsin-like receptors) pathway
Rhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and thus, can be subdivided into 19 subfamilies (Subfamily A1-19) based on a phylogenetic analysis (Joost P and Methner A, 2002).
The longest variant of each gene is displayed. Click the see gene variants link to see all gene variants.
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| Gene Symbol | Full Name |
|---|---|
| ADORA1 | adenosine A1 receptor |
| ADORA2A | adenosine A2a receptor |
| ADORA2B | adenosine A2b receptor |
| ADORA3 | adenosine A3 receptor |
| ADRA1D | adrenoceptor alpha 1D |
| ADRA1B | adrenoceptor alpha 1B |
| ADRA1A | adrenoceptor alpha 1A |
| ADRA2A | adrenoceptor alpha 2A |
| ADRA2B | adrenoceptor alpha 2B |
| ADRA2C | adrenoceptor alpha 2C |
| ADRB1 | adrenoceptor beta 1 |
| ADRB2 | adrenoceptor beta 2, surface |
| ADRB3 | adrenoceptor beta 3 |
| AGT | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) |
| AGTR1 | angiotensin II receptor, type 1 |
| AGTR2 | angiotensin II receptor, type 2 |
| APLNR | apelin receptor |
| ANXA1 | annexin A1 |
| APP | amyloid beta (A4) precursor protein |
| AVP | arginine vasopressin |
| AVPR1A | arginine vasopressin receptor 1A |
| AVPR1B | arginine vasopressin receptor 1B |
| AVPR2 | arginine vasopressin receptor 2 |
| OPN1SW | opsin 1 (cone pigments), short-wave-sensitive |
| BDKRB1 | bradykinin receptor B1 |
| BDKRB2 | bradykinin receptor B2 |
| CXCR5 | chemokine (C-X-C motif) receptor 5 |
| BRS3 | bombesin-like receptor 3 |
| C3 | complement component 3 |
| C3AR1 | complement component 3a receptor 1 |
| C5 | complement component 5 |
| C5AR1 | complement component 5a receptor 1 |
| CCK | cholecystokinin |
| CCKAR | cholecystokinin A receptor |
| CCKBR | cholecystokinin B receptor |
| CGA | glycoprotein hormones, alpha polypeptide |
| CHRM1 | cholinergic receptor, muscarinic 1 |
| CHRM2 | cholinergic receptor, muscarinic 2 |
| CHRM3 | cholinergic receptor, muscarinic 3 |
| CHRM4 | cholinergic receptor, muscarinic 4 |
| CHRM5 | cholinergic receptor, muscarinic 5 |
| CCR1 | chemokine (C-C motif) receptor 1 |
| CCR3 | chemokine (C-C motif) receptor 3 |
| CCR4 | chemokine (C-C motif) receptor 4 |
| CCR5 | chemokine (C-C motif) receptor 5 (gene/pseudogene) |
| CCR6 | chemokine (C-C motif) receptor 6 |
| CCR7 | chemokine (C-C motif) receptor 7 |
| CCR8 | chemokine (C-C motif) receptor 8 |
| ACKR2 | atypical chemokine receptor 2 |
| LTB4R | leukotriene B4 receptor |
| CNR1 | cannabinoid receptor 1 (brain) |
| CNR2 | cannabinoid receptor 2 (macrophage) |
| CX3CR1 | chemokine (C-X3-C motif) receptor 1 |
| DRD1 | dopamine receptor D1 |
| DRD2 | dopamine receptor D2 |
| DRD3 | dopamine receptor D3 |
| DRD4 | dopamine receptor D4 |
| DRD5 | dopamine receptor D5 |
| S1PR1 | sphingosine-1-phosphate receptor 1 |
| LPAR1 | lysophosphatidic acid receptor 1 |
| S1PR3 | sphingosine-1-phosphate receptor 3 |
| EDN1 | endothelin 1 |
| EDN2 | endothelin 2 |
| EDN3 | endothelin 3 |
| EDNRA | endothelin receptor type A |
| EDNRB | endothelin receptor type B |
| F2 | coagulation factor II (thrombin) |
| F2R | coagulation factor II (thrombin) receptor |
| F2RL1 | coagulation factor II (thrombin) receptor-like 1 |
| F2RL2 | coagulation factor II (thrombin) receptor-like 2 |
| FPR1 | formyl peptide receptor 1 |
| FPR2 | formyl peptide receptor 2 |
| FPR3 | formyl peptide receptor 3 |
| FSHB | follicle stimulating hormone, beta polypeptide |
| FSHR | follicle stimulating hormone receptor |
| ACKR1 | atypical chemokine receptor 1 (Duffy blood group) |
| GALR1 | galanin receptor 1 |
| OPN1MW | opsin 1 (cone pigments), medium-wave-sensitive |
| GHSR | growth hormone secretagogue receptor |
| GNRH1 | gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) |
| GNRH2 | gonadotropin-releasing hormone 2 |
| GNRHR | gonadotropin-releasing hormone receptor |
| CCR10 | chemokine (C-C motif) receptor 10 |
| GPR4 | G protein-coupled receptor 4 |
| XCR1 | chemokine (C motif) receptor 1 |
| NPBWR1 | neuropeptides B/W receptor 1 |
| NPBWR2 | neuropeptides B/W receptor 2 |
| CXCR3 | chemokine (C-X-C motif) receptor 3 |
| PRLHR | prolactin releasing hormone receptor |
| UTS2R | urotensin 2 receptor |
| GPR17 | G protein-coupled receptor 17 |
| GPR18 | G protein-coupled receptor 18 |
| LPAR4 | lysophosphatidic acid receptor 4 |
| MCHR1 | melanin-concentrating hormone receptor 1 |
| GPER1 | G protein-coupled estrogen receptor 1 |
| GPR31 | G protein-coupled receptor 31 |
| GPR37 | G protein-coupled receptor 37 (endothelin receptor type B-like) |
| MLNR | motilin receptor |
| GPR39 | G protein-coupled receptor 39 |
| FFAR1 | free fatty acid receptor 1 |