F2R cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	F2R
Entrez Gene ID	2149
Full Name	coagulation factor II thrombin receptor
Synonyms	CF2R,HTR,PAR-1,PAR1,TR
General protein information	Preferred Names coagulation factor II thrombin receptor Names proteinase-activated receptor 1 protease-activated receptor 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q13.3
Summary	Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015].
Disorder MIM:	187930

mRNA and Protein(s)

mRNA	Protein	Name
NM_001311313.1	NP_001298242.1	proteinase-activated receptor 1 isoform 2
NM_001992.4	NP_001983.2	proteinase-activated receptor 1 isoform 1 precursor
NM_001992.5	NP_001983.2	proteinase-activated receptor 1 isoform 1 precursor
NM_001311313.2	NP_001298242.1	proteinase-activated receptor 1 isoform 2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	F2R	XP_526888.3
Homo sapiens (human)	F2R	NP_001983.2
Canis lupus familiaris (dog)	F2R	XP_005618243.1
Danio rerio (zebrafish)	f2r	NP_001108318.1
Macaca mulatta (Rhesus monkey)	F2R	XP_001106136.1
Gallus gallus (chicken)	F2R	XP_004937394.1
Xenopus tropicalis (tropical clawed frog)	f2r	XP_004910450.1
Mus musculus (house mouse)	F2r	NP_034299.2
Bos taurus (cattle)	F2R	NP_001096567.1
Rattus norvegicus (Norway rat)	F2r	NP_037082.2

Gene Ontology
Bibliography

Related articles in PubMed

Protease-activated receptors are potential regulators in the development of arterial endofibrosis in high-performance athletes.
Posthuma JJ, Posma JJN, Schep G, Bender MMH, van Oerle R, van der Wal AC, Ten Cate H, Spronk HMH
Journal of vascular surgery69(4)1243-1250(2019 04)

Decidualization modulates a signal transduction system via protease-activated receptor-1 in endometrial stromal cells.
Goto K, Kawano Y, Utsunomiya T, Narahara H
American journal of reproductive immunology (New York, N.Y. : 1989)80(5)e13036(2018 11)

Noncanonical Matrix Metalloprotease 1-Protease-Activated Receptor 1 Signaling Drives Progression of Atherosclerosis.
Rana R, Huang T, Koukos G, Fletcher EK, Turner SE, Shearer A, Gurbel PA, Rade JJ, Kimmelstiel CD, Bliden KP, Covic L, Kuliopulos A
Arteriosclerosis, thrombosis, and vascular biology38(6)1368-1380(2018 06)

The Role of PAR1 Autoantibodies in Patients with Primary Epithelial Ovarian Cancer.
Kreienbring K, Franz A, Richter R, Dragun D, Heidecke H, Müller D, Mentze M, Dechend R, Sehouli J, Braicu EI
Anticancer research38(6)3619-3625(2018 Jun)

Protease signaling through protease activated receptor 1 mediate nerve activation by mucosal supernatants from irritable bowel syndrome but not from ulcerative colitis patients.
Buhner S, Hahne H, Hartwig K, Li Q, Vignali S, Ostertag D, Meng C, Hörmannsperger G, Braak B, Pehl C, Frieling T, Barbara G, De Giorgio R, Demir IE, Ceyhan GO, Zeller F, Boeckxstaens G, Haller D, Kuster B, Schemann M
PloS one13(3)e0193943(2018)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following F2R gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the F2R cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu57661	NM_001311313.2 Latest version!	Homo sapiens coagulation factor II thrombin receptor (F2R), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu18455	NM_001992.5 Latest version!	Homo sapiens coagulation factor II thrombin receptor (F2R), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$265.30 $379.00
View Old Accession Versions >>
OHu18455	NM_001992.4	Homo sapiens coagulation factor II thrombin receptor (F2R), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$265.30 $379.00
OHu57661	NM_001311313.1	Homo sapiens coagulation factor II thrombin receptor (F2R), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

F2R ( NM_001311313.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001298242.1 Homo sapiens coagulation factor II thrombin receptor (F2R), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu57661
Clone ID Related Accession (Same CDS sequence)	NM_001311313.1 , NM_001311313.2
Accession Version	NM_001311313.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 915bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1543766400000
Organism	Homo sapiens(human)
Product	proteinase-activated receptor 1 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK308169.1, DA799420.1, BC051909.1, BM994328.1 and N35000.1. Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation from a downstream start codon, compared to variant 1. It encodes isoform 2, which is shorter at the N-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DB226916.1, DA799420.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2155628, SAMN01820691 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCATCG TTGTGTTCAT CCTGAAAATG AAGGTCAAGA AGCCGGCGGT GGTGTACATG 
CTGCACCTGG CCACGGCAGA TGTGCTGTTT GTGTCTGTGC TCCCCTTTAA GATCAGCTAT 
TACTTTTCCG GCAGTGATTG GCAGTTTGGG TCTGAATTGT GTCGCTTCGT CACTGCAGCA 
TTTTACTGTA ACATGTACGC CTCTATCTTG CTCATGACAG TCATAAGCAT TGACCGGTTT 
CTGGCTGTGG TGTATCCCAT GCAGTCCCTC TCCTGGCGTA CTCTGGGAAG GGCTTCCTTC 
ACTTGTCTGG CCATCTGGGC TTTGGCCATC GCAGGGGTAG TGCCTCTGCT CCTCAAGGAG 
CAAACCATCC AGGTGCCCGG GCTCAACATC ACTACCTGTC ATGATGTGCT CAATGAAACC 
CTGCTCGAAG GCTACTATGC CTACTACTTC TCAGCCTTCT CTGCTGTCTT CTTTTTTGTG 
CCGCTGATCA TTTCCACGGT CTGTTATGTG TCTATCATTC GATGTCTTAG CTCTTCCGCA 
GTTGCCAACC GCAGCAAGAA GTCCCGGGCT TTGTTCCTGT CAGCTGCTGT TTTCTGCATC 
TTCATCATTT GCTTCGGACC CACAAACGTC CTCCTGATTG CGCATTACTC ATTCCTTTCT 
CACACTTCCA CCACAGAGGC TGCCTACTTT GCCTACCTCC TCTGTGTCTG TGTCAGCAGC 
ATAAGCTGCT GCATCGACCC CCTAATTTAC TATTACGCTT CCTCTGAGTG CCAGAGGTAC 
GTCTACAGTA TCTTATGCTG CAAAGAAAGT TCCGATCCCA GCAGTTATAA CAGCAGTGGG 
CAGTTGATGG CAAGTAAAAT GGATACCTGC TCTAGTAACC TGAATAACAG CATATACAAA 
AAGCTGTTAA CTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001298242.1
CDS	751..1665
Translation	MAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTAAFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSSAVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVSSISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIYKKLLT

Target ORF information:

RefSeq Version	NM_001311313.1
Organism	Homo sapiens(human)
Definition	Homo sapiens coagulation factor II thrombin receptor (F2R), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001311313.1

ORF Insert Sequence:

ATGGCCATCG TTGTGTTCAT CCTGAAAATG AAGGTCAAGA AGCCGGCGGT GGTGTACATG 
CTGCACCTGG CCACGGCAGA TGTGCTGTTT GTGTCTGTGC TCCCCTTTAA GATCAGCTAT 
TACTTTTCCG GCAGTGATTG GCAGTTTGGG TCTGAATTGT GTCGCTTCGT CACTGCAGCA 
TTTTACTGTA ACATGTACGC CTCTATCTTG CTCATGACAG TCATAAGCAT TGACCGGTTT 
CTGGCTGTGG TGTATCCCAT GCAGTCCCTC TCCTGGCGTA CTCTGGGAAG GGCTTCCTTC 
ACTTGTCTGG CCATCTGGGC TTTGGCCATC GCAGGGGTAG TGCCTCTGCT CCTCAAGGAG 
CAAACCATCC AGGTGCCCGG GCTCAACATC ACTACCTGTC ATGATGTGCT CAATGAAACC 
CTGCTCGAAG GCTACTATGC CTACTACTTC TCAGCCTTCT CTGCTGTCTT CTTTTTTGTG 
CCGCTGATCA TTTCCACGGT CTGTTATGTG TCTATCATTC GATGTCTTAG CTCTTCCGCA 
GTTGCCAACC GCAGCAAGAA GTCCCGGGCT TTGTTCCTGT CAGCTGCTGT TTTCTGCATC 
TTCATCATTT GCTTCGGACC CACAAACGTC CTCCTGATTG CGCATTACTC ATTCCTTTCT 
CACACTTCCA CCACAGAGGC TGCCTACTTT GCCTACCTCC TCTGTGTCTG TGTCAGCAGC 
ATAAGCTGCT GCATCGACCC CCTAATTTAC TATTACGCTT CCTCTGAGTG CCAGAGGTAC 
GTCTACAGTA TCTTATGCTG CAAAGAAAGT TCCGATCCCA GCAGTTATAA CAGCAGTGGG 
CAGTTGATGG CAAGTAAAAT GGATACCTGC TCTAGTAACC TGAATAACAG CATATACAAA 
AAGCTGTTAA CTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

F2R ( NM_001311313.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001298242.1 Homo sapiens coagulation factor II thrombin receptor (F2R), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu57661
Clone ID Related Accession (Same CDS sequence)	NM_001311313.1 , NM_001311313.2
Accession Version	NM_001311313.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 915bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1574611200000
Organism	Homo sapiens(human)
Product	proteinase-activated receptor 1 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK308169.1, DA799420.1, BC051909.1 and BM994328.1. On May 31, 2019 this sequence version replaced NM_001311313.1. Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation from a downstream start codon, compared to variant 1. It encodes isoform 2, which is shorter at the N-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA2155628, SAMN01820691 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCATCG TTGTGTTCAT CCTGAAAATG AAGGTCAAGA AGCCGGCGGT GGTGTACATG 
CTGCACCTGG CCACGGCAGA TGTGCTGTTT GTGTCTGTGC TCCCCTTTAA GATCAGCTAT 
TACTTTTCCG GCAGTGATTG GCAGTTTGGG TCTGAATTGT GTCGCTTCGT CACTGCAGCA 
TTTTACTGTA ACATGTACGC CTCTATCTTG CTCATGACAG TCATAAGCAT TGACCGGTTT 
CTGGCTGTGG TGTATCCCAT GCAGTCCCTC TCCTGGCGTA CTCTGGGAAG GGCTTCCTTC 
ACTTGTCTGG CCATCTGGGC TTTGGCCATC GCAGGGGTAG TGCCTCTGCT CCTCAAGGAG 
CAAACCATCC AGGTGCCCGG GCTCAACATC ACTACCTGTC ATGATGTGCT CAATGAAACC 
CTGCTCGAAG GCTACTATGC CTACTACTTC TCAGCCTTCT CTGCTGTCTT CTTTTTTGTG 
CCGCTGATCA TTTCCACGGT CTGTTATGTG TCTATCATTC GATGTCTTAG CTCTTCCGCA 
GTTGCCAACC GCAGCAAGAA GTCCCGGGCT TTGTTCCTGT CAGCTGCTGT TTTCTGCATC 
TTCATCATTT GCTTCGGACC CACAAACGTC CTCCTGATTG CGCATTACTC ATTCCTTTCT 
CACACTTCCA CCACAGAGGC TGCCTACTTT GCCTACCTCC TCTGTGTCTG TGTCAGCAGC 
ATAAGCTGCT GCATCGACCC CCTAATTTAC TATTACGCTT CCTCTGAGTG CCAGAGGTAC 
GTCTACAGTA TCTTATGCTG CAAAGAAAGT TCCGATCCCA GCAGTTATAA CAGCAGTGGG 
CAGTTGATGG CAAGTAAAAT GGATACCTGC TCTAGTAACC TGAATAACAG CATATACAAA 
AAGCTGTTAA CTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001298242.1
CDS	668..1582
Translation	MAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTAAFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSSAVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVSSISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIYKKLLT

Target ORF information:

RefSeq Version	NM_001311313.2
Organism	Homo sapiens(human)
Definition	Homo sapiens coagulation factor II thrombin receptor (F2R), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001311313.2

ORF Insert Sequence:

ATGGCCATCG TTGTGTTCAT CCTGAAAATG AAGGTCAAGA AGCCGGCGGT GGTGTACATG 
CTGCACCTGG CCACGGCAGA TGTGCTGTTT GTGTCTGTGC TCCCCTTTAA GATCAGCTAT 
TACTTTTCCG GCAGTGATTG GCAGTTTGGG TCTGAATTGT GTCGCTTCGT CACTGCAGCA 
TTTTACTGTA ACATGTACGC CTCTATCTTG CTCATGACAG TCATAAGCAT TGACCGGTTT 
CTGGCTGTGG TGTATCCCAT GCAGTCCCTC TCCTGGCGTA CTCTGGGAAG GGCTTCCTTC 
ACTTGTCTGG CCATCTGGGC TTTGGCCATC GCAGGGGTAG TGCCTCTGCT CCTCAAGGAG 
CAAACCATCC AGGTGCCCGG GCTCAACATC ACTACCTGTC ATGATGTGCT CAATGAAACC 
CTGCTCGAAG GCTACTATGC CTACTACTTC TCAGCCTTCT CTGCTGTCTT CTTTTTTGTG 
CCGCTGATCA TTTCCACGGT CTGTTATGTG TCTATCATTC GATGTCTTAG CTCTTCCGCA 
GTTGCCAACC GCAGCAAGAA GTCCCGGGCT TTGTTCCTGT CAGCTGCTGT TTTCTGCATC 
TTCATCATTT GCTTCGGACC CACAAACGTC CTCCTGATTG CGCATTACTC ATTCCTTTCT 
CACACTTCCA CCACAGAGGC TGCCTACTTT GCCTACCTCC TCTGTGTCTG TGTCAGCAGC 
ATAAGCTGCT GCATCGACCC CCTAATTTAC TATTACGCTT CCTCTGAGTG CCAGAGGTAC 
GTCTACAGTA TCTTATGCTG CAAAGAAAGT TCCGATCCCA GCAGTTATAA CAGCAGTGGG 
CAGTTGATGG CAAGTAAAAT GGATACCTGC TCTAGTAACC TGAATAACAG CATATACAAA 
AAGCTGTTAA CTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

F2R ( NM_001992.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001983.2 Homo sapiens coagulation factor II thrombin receptor (F2R), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu18455
Clone ID Related Accession (Same CDS sequence)	NM_001992.4 , NM_001992.5
Accession Version	NM_001992.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1278bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1513440000000
Organism	Homo sapiens(human)
Product	proteinase-activated receptor 1 isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK308169.1, BC051909.1, BM994328.1 and N35000.1. This sequence is a reference standard in the RefSeqGene project. On Aug 7, 2015 this sequence version replaced NM_001992.3. Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGCCGC GGCGGCTGCT GCTGGTGGCC GCCTGCTTCA GTCTGTGCGG CCCGCTGTTG 
TCTGCCCGCA CCCGGGCCCG CAGGCCAGAA TCAAAAGCAA CAAATGCCAC CTTAGATCCC 
CGGTCATTTC TTCTCAGGAA CCCCAATGAT AAATATGAAC CATTTTGGGA GGATGAGGAG 
AAAAATGAAA GTGGGTTAAC TGAATACAGA TTAGTCTCCA TCAATAAAAG CAGTCCTCTT 
CAAAAACAAC TTCCTGCATT CATCTCAGAA GATGCCTCCG GATATTTGAC CAGCTCCTGG 
CTGACACTCT TTGTCCCATC TGTGTACACC GGAGTGTTTG TAGTCAGCCT CCCACTAAAC 
ATCATGGCCA TCGTTGTGTT CATCCTGAAA ATGAAGGTCA AGAAGCCGGC GGTGGTGTAC 
ATGCTGCACC TGGCCACGGC AGATGTGCTG TTTGTGTCTG TGCTCCCCTT TAAGATCAGC 
TATTACTTTT CCGGCAGTGA TTGGCAGTTT GGGTCTGAAT TGTGTCGCTT CGTCACTGCA 
GCATTTTACT GTAACATGTA CGCCTCTATC TTGCTCATGA CAGTCATAAG CATTGACCGG 
TTTCTGGCTG TGGTGTATCC CATGCAGTCC CTCTCCTGGC GTACTCTGGG AAGGGCTTCC 
TTCACTTGTC TGGCCATCTG GGCTTTGGCC ATCGCAGGGG TAGTGCCTCT GCTCCTCAAG 
GAGCAAACCA TCCAGGTGCC CGGGCTCAAC ATCACTACCT GTCATGATGT GCTCAATGAA 
ACCCTGCTCG AAGGCTACTA TGCCTACTAC TTCTCAGCCT TCTCTGCTGT CTTCTTTTTT 
GTGCCGCTGA TCATTTCCAC GGTCTGTTAT GTGTCTATCA TTCGATGTCT TAGCTCTTCC 
GCAGTTGCCA ACCGCAGCAA GAAGTCCCGG GCTTTGTTCC TGTCAGCTGC TGTTTTCTGC 
ATCTTCATCA TTTGCTTCGG ACCCACAAAC GTCCTCCTGA TTGCGCATTA CTCATTCCTT 
TCTCACACTT CCACCACAGA GGCTGCCTAC TTTGCCTACC TCCTCTGTGT CTGTGTCAGC 
AGCATAAGCT GCTGCATCGA CCCCCTAATT TACTATTACG CTTCCTCTGA GTGCCAGAGG 
TACGTCTACA GTATCTTATG CTGCAAAGAA AGTTCCGATC CCAGCAGTTA TAACAGCAGT 
GGGCAGTTGA TGGCAAGTAA AATGGATACC TGCTCTAGTA ACCTGAATAA CAGCATATAC 
AAAAAGCTGT TAACTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001983.2
CDS	266..1543
Translation	MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEEKNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLNIMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTAAFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSSAVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVSSISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIYKKLLT

Target ORF information:

RefSeq Version	NM_001992.4
Organism	Homo sapiens(human)
Definition	Homo sapiens coagulation factor II thrombin receptor (F2R), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001992.4

ORF Insert Sequence:

ATGGGGCCGC GGCGGCTGCT GCTGGTGGCC GCCTGCTTCA GTCTGTGCGG CCCGCTGTTG 
TCTGCCCGCA CCCGGGCCCG CAGGCCAGAA TCAAAAGCAA CAAATGCCAC CTTAGATCCC 
CGGTCATTTC TTCTCAGGAA CCCCAATGAT AAATATGAAC CATTTTGGGA GGATGAGGAG 
AAAAATGAAA GTGGGTTAAC TGAATACAGA TTAGTCTCCA TCAATAAAAG CAGTCCTCTT 
CAAAAACAAC TTCCTGCATT CATCTCAGAA GATGCCTCCG GATATTTGAC CAGCTCCTGG 
CTGACACTCT TTGTCCCATC TGTGTACACC GGAGTGTTTG TAGTCAGCCT CCCACTAAAC 
ATCATGGCCA TCGTTGTGTT CATCCTGAAA ATGAAGGTCA AGAAGCCGGC GGTGGTGTAC 
ATGCTGCACC TGGCCACGGC AGATGTGCTG TTTGTGTCTG TGCTCCCCTT TAAGATCAGC 
TATTACTTTT CCGGCAGTGA TTGGCAGTTT GGGTCTGAAT TGTGTCGCTT CGTCACTGCA 
GCATTTTACT GTAACATGTA CGCCTCTATC TTGCTCATGA CAGTCATAAG CATTGACCGG 
TTTCTGGCTG TGGTGTATCC CATGCAGTCC CTCTCCTGGC GTACTCTGGG AAGGGCTTCC 
TTCACTTGTC TGGCCATCTG GGCTTTGGCC ATCGCAGGGG TAGTGCCTCT GCTCCTCAAG 
GAGCAAACCA TCCAGGTGCC CGGGCTCAAC ATCACTACCT GTCATGATGT GCTCAATGAA 
ACCCTGCTCG AAGGCTACTA TGCCTACTAC TTCTCAGCCT TCTCTGCTGT CTTCTTTTTT 
GTGCCGCTGA TCATTTCCAC GGTCTGTTAT GTGTCTATCA TTCGATGTCT TAGCTCTTCC 
GCAGTTGCCA ACCGCAGCAA GAAGTCCCGG GCTTTGTTCC TGTCAGCTGC TGTTTTCTGC 
ATCTTCATCA TTTGCTTCGG ACCCACAAAC GTCCTCCTGA TTGCGCATTA CTCATTCCTT 
TCTCACACTT CCACCACAGA GGCTGCCTAC TTTGCCTACC TCCTCTGTGT CTGTGTCAGC 
AGCATAAGCT GCTGCATCGA CCCCCTAATT TACTATTACG CTTCCTCTGA GTGCCAGAGG 
TACGTCTACA GTATCTTATG CTGCAAAGAA AGTTCCGATC CCAGCAGTTA TAACAGCAGT 
GGGCAGTTGA TGGCAAGTAA AATGGATACC TGCTCTAGTA ACCTGAATAA CAGCATATAC 
AAAAAGCTGT TAACTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

F2R ( NM_001992.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_001983.2 Homo sapiens coagulation factor II thrombin receptor (F2R), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu18455
Clone ID Related Accession (Same CDS sequence)	NM_001992.4 , NM_001992.5
Accession Version	NM_001992.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1278bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577635200000
Organism	Homo sapiens(human)
Product	proteinase-activated receptor 1 isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC051909.1 and BM994328.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_001992.4. Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DA405909.1, SRR1803613.270776.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000319211.5/ ENSP00000321326.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGGCCGC GGCGGCTGCT GCTGGTGGCC GCCTGCTTCA GTCTGTGCGG CCCGCTGTTG 
TCTGCCCGCA CCCGGGCCCG CAGGCCAGAA TCAAAAGCAA CAAATGCCAC CTTAGATCCC 
CGGTCATTTC TTCTCAGGAA CCCCAATGAT AAATATGAAC CATTTTGGGA GGATGAGGAG 
AAAAATGAAA GTGGGTTAAC TGAATACAGA TTAGTCTCCA TCAATAAAAG CAGTCCTCTT 
CAAAAACAAC TTCCTGCATT CATCTCAGAA GATGCCTCCG GATATTTGAC CAGCTCCTGG 
CTGACACTCT TTGTCCCATC TGTGTACACC GGAGTGTTTG TAGTCAGCCT CCCACTAAAC 
ATCATGGCCA TCGTTGTGTT CATCCTGAAA ATGAAGGTCA AGAAGCCGGC GGTGGTGTAC 
ATGCTGCACC TGGCCACGGC AGATGTGCTG TTTGTGTCTG TGCTCCCCTT TAAGATCAGC 
TATTACTTTT CCGGCAGTGA TTGGCAGTTT GGGTCTGAAT TGTGTCGCTT CGTCACTGCA 
GCATTTTACT GTAACATGTA CGCCTCTATC TTGCTCATGA CAGTCATAAG CATTGACCGG 
TTTCTGGCTG TGGTGTATCC CATGCAGTCC CTCTCCTGGC GTACTCTGGG AAGGGCTTCC 
TTCACTTGTC TGGCCATCTG GGCTTTGGCC ATCGCAGGGG TAGTGCCTCT GCTCCTCAAG 
GAGCAAACCA TCCAGGTGCC CGGGCTCAAC ATCACTACCT GTCATGATGT GCTCAATGAA 
ACCCTGCTCG AAGGCTACTA TGCCTACTAC TTCTCAGCCT TCTCTGCTGT CTTCTTTTTT 
GTGCCGCTGA TCATTTCCAC GGTCTGTTAT GTGTCTATCA TTCGATGTCT TAGCTCTTCC 
GCAGTTGCCA ACCGCAGCAA GAAGTCCCGG GCTTTGTTCC TGTCAGCTGC TGTTTTCTGC 
ATCTTCATCA TTTGCTTCGG ACCCACAAAC GTCCTCCTGA TTGCGCATTA CTCATTCCTT 
TCTCACACTT CCACCACAGA GGCTGCCTAC TTTGCCTACC TCCTCTGTGT CTGTGTCAGC 
AGCATAAGCT GCTGCATCGA CCCCCTAATT TACTATTACG CTTCCTCTGA GTGCCAGAGG 
TACGTCTACA GTATCTTATG CTGCAAAGAA AGTTCCGATC CCAGCAGTTA TAACAGCAGT 
GGGCAGTTGA TGGCAAGTAA AATGGATACC TGCTCTAGTA ACCTGAATAA CAGCATATAC 
AAAAAGCTGT TAACTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001983.2
CDS	183..1460
Translation	MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEEKNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLNIMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTAAFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSSAVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVSSISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIYKKLLT

Target ORF information:

RefSeq Version	NM_001992.5
Organism	Homo sapiens(human)
Definition	Homo sapiens coagulation factor II thrombin receptor (F2R), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001992.5

ORF Insert Sequence:

ATGGGGCCGC GGCGGCTGCT GCTGGTGGCC GCCTGCTTCA GTCTGTGCGG CCCGCTGTTG 
TCTGCCCGCA CCCGGGCCCG CAGGCCAGAA TCAAAAGCAA CAAATGCCAC CTTAGATCCC 
CGGTCATTTC TTCTCAGGAA CCCCAATGAT AAATATGAAC CATTTTGGGA GGATGAGGAG 
AAAAATGAAA GTGGGTTAAC TGAATACAGA TTAGTCTCCA TCAATAAAAG CAGTCCTCTT 
CAAAAACAAC TTCCTGCATT CATCTCAGAA GATGCCTCCG GATATTTGAC CAGCTCCTGG 
CTGACACTCT TTGTCCCATC TGTGTACACC GGAGTGTTTG TAGTCAGCCT CCCACTAAAC 
ATCATGGCCA TCGTTGTGTT CATCCTGAAA ATGAAGGTCA AGAAGCCGGC GGTGGTGTAC 
ATGCTGCACC TGGCCACGGC AGATGTGCTG TTTGTGTCTG TGCTCCCCTT TAAGATCAGC 
TATTACTTTT CCGGCAGTGA TTGGCAGTTT GGGTCTGAAT TGTGTCGCTT CGTCACTGCA 
GCATTTTACT GTAACATGTA CGCCTCTATC TTGCTCATGA CAGTCATAAG CATTGACCGG 
TTTCTGGCTG TGGTGTATCC CATGCAGTCC CTCTCCTGGC GTACTCTGGG AAGGGCTTCC 
TTCACTTGTC TGGCCATCTG GGCTTTGGCC ATCGCAGGGG TAGTGCCTCT GCTCCTCAAG 
GAGCAAACCA TCCAGGTGCC CGGGCTCAAC ATCACTACCT GTCATGATGT GCTCAATGAA 
ACCCTGCTCG AAGGCTACTA TGCCTACTAC TTCTCAGCCT TCTCTGCTGT CTTCTTTTTT 
GTGCCGCTGA TCATTTCCAC GGTCTGTTAT GTGTCTATCA TTCGATGTCT TAGCTCTTCC 
GCAGTTGCCA ACCGCAGCAA GAAGTCCCGG GCTTTGTTCC TGTCAGCTGC TGTTTTCTGC 
ATCTTCATCA TTTGCTTCGG ACCCACAAAC GTCCTCCTGA TTGCGCATTA CTCATTCCTT 
TCTCACACTT CCACCACAGA GGCTGCCTAC TTTGCCTACC TCCTCTGTGT CTGTGTCAGC 
AGCATAAGCT GCTGCATCGA CCCCCTAATT TACTATTACG CTTCCTCTGA GTGCCAGAGG 
TACGTCTACA GTATCTTATG CTGCAAAGAA AGTTCCGATC CCAGCAGTTA TAACAGCAGT 
GGGCAGTTGA TGGCAAGTAA AATGGATACC TGCTCTAGTA ACCTGAATAA CAGCATATAC 
AAAAAGCTGT TAACTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Protease-activated receptors are potential regulators in the development of arterial endofibrosis in high-performance athletes.
Journal of vascular surgery69(4)1243-1250(2019 04)
Posthuma JJ,Posma JJN,Schep G,Bender MMH,van Oerle R,van der Wal AC,Ten Cate H,Spronk HMH

Decidualization modulates a signal transduction system via protease-activated receptor-1 in endometrial stromal cells.
American journal of reproductive immunology (New York, N.Y. : 1989)80(5)e13036(2018 11)
Goto K,Kawano Y,Utsunomiya T,Narahara H

Noncanonical Matrix Metalloprotease 1-Protease-Activated Receptor 1 Signaling Drives Progression of Atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology38(6)1368-1380(2018 06)
Rana R,Huang T,Koukos G,Fletcher EK,Turner SE,Shearer A,Gurbel PA,Rade JJ,Kimmelstiel CD,Bliden KP,Covic L,Kuliopulos A

The Role of PAR1 Autoantibodies in Patients with Primary Epithelial Ovarian Cancer.
Anticancer research38(6)3619-3625(2018 Jun)
Kreienbring K,Franz A,Richter R,Dragun D,Heidecke H,Müller D,Mentze M,Dechend R,Sehouli J,Braicu EI

Protease signaling through protease activated receptor 1 mediate nerve activation by mucosal supernatants from irritable bowel syndrome but not from ulcerative colitis patients.
PloS one13(3)e0193943(2018)
Buhner S,Hahne H,Hartwig K,Li Q,Vignali S,Ostertag D,Meng C,Hörmannsperger G,Braak B,Pehl C,Frieling T,Barbara G,De Giorgio R,Demir IE,Ceyhan GO,Zeller F,Boeckxstaens G,Haller D,Kuster B,Schemann M

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F2R cDNA ORF clone, Homo sapiens(human)

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Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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