| Gene Symbol | Bsnd |
| Entrez Gene ID | 192675 |
| Full Name | barttin CLCNK type accessory beta subunit |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Rattus norvegicus(Norway rat) |
| Genome | |
| Summary | binds to and activates ClC-K channels and is required for adequate tubular salt reabsorption in the kidney [RGD, Feb 2006]. |
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Bsnd cDNA ORF clone, Rattus norvegicus(Norway rat)
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Gene
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Clones
gRNAs
The following Bsnd gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Bsnd cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID ORa13885 Clone ID Related Accession (Same CDS sequence) NM_138979.2 Accession Version NM_138979.2 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 927bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1577203200000 Organism Rattus norvegicus(Norway rat) Product barttin Comment Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC081725.1. On Sep 16, 2004 this sequence version replaced NM_138979.1. ##Evidence-Data-START## Transcript exon combination :: BC081725.1, AJ421029.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901ATGGCTGACG AGAAGACCTT CCGAATCGGT TTCATCGTGC TGGGCCTTTT CCTGCTATCC
CTGGGCACAT TCCTTATGAG CCACGATCGA CCCCAAGTCT ACGGCACCTT CTATGCCATG
GGCAGCATCA TGGTGATTGG GGGTGTCCTC TGGAGCATGT GCCAATGCTA TCCTAAGATC
ACCTTTGTGC CGGCAGACTC TGACTTCCAA GGCATGTTGT CCCCAAAGGC CCTGAGCCTG
CTGGAGACTG GGCTTTCAGA AGTAAAGAGC CCCCAGCCCC CCTACGTCAG GCTGTGGGAA
GAAGCCGCTT ATGACCAGAG CCTCCCAGAC TTCACTCACA TCCAAATGAA GGTCATGGGC
TACAGTGAGG ACCCCAGGCC ACTGCTGGCC CCCGAACTGA AGACAGGAAC CAGCAGTGCC
AAGGAAGGCG AGCCTCATTC TGCTCAGACC TGGATGGAGG CTGCGGTGGT CGTCCATAGA
GAGTTGGATG AGAAGGAGGG AGAGAAATCT CGTTCTCAGA GCAGCCCTCC AGCGTGTTCC
CAAGGCTCTG CACCCTTGGC GTCATTTCAC GATGACTTGG ACGTGGGTTC TAGCGAAGGC
CGCAGCCCCC AGCCATCCCC ACCTGACAGA GATGAGGCAC ACCTGCAGGT GCCCTGGGCC
AGCAGAGGTC CACTGGATCG CTTCGGTGAC TTTGCTCTGA TTGATGACAC CCCTATATCA
GAGGACATGG GCCTGGAGGG GCAGGCACAG GAGGAAGCTC TACCCAGCAA GCAACCATGG
TCCCTGAGGA TGAAGGAGGA GACTGTCCAG GCAGGTGCAG AAGAACCAGA GCAGGAGGAG
GAAGATCTGT ACTACGGGCT GCCCGACAGC CCTGGGGACC CCCTCCCTGA CAAAGAGTTG
GGCTTTGAGC CTGATGTCCA GGGTTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_620435.1 CDS 200..1126 Translation 
Target ORF information:
RefSeq Version NM_138979.2 Organism Rattus norvegicus(Norway rat) Definition Rattus norvegicus barttin CLCNK type accessory subunit beta (Bsnd), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_138979.2
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901ATGGCTGACG AGAAGACCTT CCGAATCGGT TTCATCGTGC TGGGCCTTTT CCTGCTATCC
CTGGGCACAT TCCTTATGAG CCACGATCGA CCCCAAGTCT ACGGCACCTT CTATGCCATG
GGCAGCATCA TGGTGATTGG GGGTGTCCTC TGGAGCATGT GCCAATGCTA TCCTAAGATC
ACCTTTGTGC CGGCAGACTC TGACTTCCAA GGCATGTTGT CCCCAAAGGC CCTGAGCCTG
CTGGAGACTG GGCTTTCAGA AGTAAAGAGC CCCCAGCCCC CCTACGTCAG GCTGTGGGAA
GAAGCCGCTT ATGACCAGAG CCTCCCAGAC TTCACTCACA TCCAAATGAA GGTCATGGGC
TACAGTGAGG ACCCCAGGCC ACTGCTGGCC CCCGAACTGA AGACAGGAAC CAGCAGTGCC
AAGGAAGGCG AGCCTCATTC TGCTCAGACC TGGATGGAGG CTGCGGTGGT CGTCCATAGA
GAGTTGGATG AGAAGGAGGG AGAGAAATCT CGTTCTCAGA GCAGCCCTCC AGCGTGTTCC
CAAGGCTCTG CACCCTTGGC GTCATTTCAC GATGACTTGG ACGTGGGTTC TAGCGAAGGC
CGCAGCCCCC AGCCATCCCC ACCTGACAGA GATGAGGCAC ACCTGCAGGT GCCCTGGGCC
AGCAGAGGTC CACTGGATCG CTTCGGTGAC TTTGCTCTGA TTGATGACAC CCCTATATCA
GAGGACATGG GCCTGGAGGG GCAGGCACAG GAGGAAGCTC TACCCAGCAA GCAACCATGG
TCCCTGAGGA TGAAGGAGGA GACTGTCCAG GCAGGTGCAG AAGAACCAGA GCAGGAGGAG
GAAGATCTGT ACTACGGGCT GCCCGACAGC CCTGGGGACC CCCTCCCTGA CAAAGAGTTG
GGCTTTGAGC CTGATGTCCA GGGTTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
Molecular architecture of the stria vascularis membrane transport system, which is essential for physiological functions of the mammalian cochlea.
The European journal of neuroscience42(3)1984-2002(2015 Aug)
Uetsuka S,Ogata G,Nagamori S,Isozumi N,Nin F,Yoshida T,Komune S,Kitahara T,Kikkawa Y,Inohara H,Kanai Y,Hibino H
Parallel down-regulation of chloride channel CLC-K1 and barttin mRNA in the thin ascending limb of the rat nephron by furosemide.
Pflugers Archiv : European journal of physiology446(6)665-71(2003 Sep)
Wolf K,Meier-Meitinger M,Bergler T,Castrop H,Vitzthum H,Riegger GA,Kurtz A,Krämer BK
Barttin increases surface expression and changes current properties of ClC-K channels.
Pflugers Archiv : European journal of physiology444(3)411-8(2002 Jun)
Waldegger S,Jeck N,Barth P,Peters M,Vitzthum H,Wolf K,Kurtz A,Konrad M,Seyberth HW
Mutation of BSND causes Bartter syndrome with sensorineural deafness and kidney failure.
Nature genetics29(3)310-4(2001 Nov)
Birkenhäger R,Otto E,Schürmann MJ,Vollmer M,Ruf EM,Maier-Lutz I,Beekmann F,Fekete A,Omran H,Feldmann D,Milford DV,Jeck N,Konrad M,Landau D,Knoers NV,Antignac C,Sudbrak R,Kispert A,Hildebrandt F
Barttin is a Cl- channel beta-subunit crucial for renal Cl- reabsorption and inner ear K+ secretion.
Nature414(6863)558-61(2001 Nov)
Estévez R,Boettger T,Stein V,Birkenhäger R,Otto E,Hildebrandt F,Jentsch TJ
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