Bmpr2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Bmpr2
Entrez Gene ID	140590
Full Name	bone morphogenetic protein receptor type 2
Synonyms	Bmpr-II
General protein information	Preferred Names bone morphogenetic protein receptor type 2 Names bone morphogenetic protein receptor type-2 bone morphogenetic protein receptor type II bone morphogenetic protein receptor, type II (serine/threonine kinase) bone morphogenic protein receptor, type II (serine/threonine kinase)
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 9 Map Location: 9q31
Summary	human homolog is a receptor for bone morpogenetic proteins and plays a role in bone development [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006244951.3	XP_006245013.1	bone morphogenetic protein receptor type-2 isoform X1
XM_006244952.3	XP_006245014.1	bone morphogenetic protein receptor type-2 isoform X2
NM_080407.1	NP_536332.1	bone morphogenetic protein receptor type-2 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	BMPR2	NP_001195.2
Macaca mulatta (Rhesus monkey)	BMPR2	XP_001101663.1
Danio rerio (zebrafish)	bmpr2b	NP_001034896.1
Pan troglodytes (chimpanzee)	BMPR2	XP_001172748.1
Mus musculus (house mouse)	Bmpr2	NP_031587.1
Bos taurus (cattle)	BMPR2	XP_002685538.2
Gallus gallus (chicken)	BMPR2	NP_001001465.1
Canis lupus familiaris (dog)	BMPR2	XP_536035.3
Rattus norvegicus (Norway rat)	Bmpr2	NP_536332.1
Xenopus tropicalis (tropical clawed frog)	bmpr2	XP_002937761.2

Gene Ontology
Bibliography

Related articles in PubMed

Bmpr2 Mutant Rats Develop Pulmonary and Cardiac Characteristics of Pulmonary Arterial Hypertension.
Hautefort A, Mendes-Ferreira P, Sabourin J, Manaud G, Bertero T, Rucker-Martin C, Riou M, Adão R, Manoury B, Lambert M, Boet A, Lecerf F, Domergue V, Brás-Silva C, Gomez AM, Montani D, Girerd B, Humbert M, Antigny F, Perros F
Circulation139(7)932-948(2019 02)

MiR-143-3p regulates early cartilage differentiation of BMSCs and promotes cartilage damage repair through targeting BMPR2.
Tian J, Rui YJ, Xu YJ, Zhang SA
European review for medical and pharmacological sciences22(24)8814-8821(2018 12)

Network of MicroRNAs Mediate Translational Repression of Bone Morphogenetic Protein Receptor-2: Involvement in HIV-Associated Pulmonary Vascular Remodeling.
Chinnappan M, Mohan A, Agarwal S, Dalvi P, Dhillon NK
Journal of the American Heart Association7(5)(2018 02)

Let-7a-transfected mesenchymal stem cells ameliorate monocrotaline-induced pulmonary hypertension by suppressing pulmonary artery smooth muscle cell growth through STAT3-BMPR2 signaling.
Cheng G, Wang X, Li Y, He L
Stem cell research & therapy8(1)34(2017 02)

Pulsed electromagnetic fields stimulate osteogenic differentiation and maturation of osteoblasts by upregulating the expression of BMPRII localized at the base of primary cilium.
Xie YF, Shi WG, Zhou J, Gao YH, Li SF, Fang QQ, Wang MG, Ma HP, Wang JF, Xian CJ, Chen KM
Bone9322-32(2016 12)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Bmpr2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Bmpr2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa11763	NM_080407.1 Latest version!	Rattus norvegicus bone morphogenetic protein receptor type 2 (Bmpr2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$559.30 $799.00
ORa32217	XM_006244951.3 Latest version!	Rattus norvegicus bone morphogenetic protein receptor type 2 (Bmpr2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$559.30 $799.00
ORa32218	XM_006244952.3 Latest version!	Rattus norvegicus bone morphogenetic protein receptor type 2 (Bmpr2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$559.30 $799.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Bmpr2 ( NM_080407.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_536332.1 Rattus norvegicus bone morphogenetic protein receptor type 2 (Bmpr2), mRNA.

Price & Availability↑

CloneID	ORa11763
Clone ID Related Accession (Same CDS sequence)	NM_080407.1
Accession Version	NM_080407.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3117bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1576339200000
Organism	Rattus norvegicus(Norway rat)
Product	bone morphogenetic protein receptor type-2 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473965.2. On or before Dec 19, 2009 this sequence version replaced XM_001065181.1, XM_217409.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGACTTCCT CGCTGCAGCG GCCCTTTCGG GTGCCCTGGC TGTTATGGGC CGTCCTGCTG 
GTCAGCACTA CGGCTGCTTC CCAGAATCAA GAACGGCTGT GTGCATTTAA AGACCCGTAT 
CAACAAGACC TTGGGATTGG TGAGAGTCGA ATCTCTCATG AAAATGGGAC AATATTATGC 
TCCAAAGGGA GCACATGTTA TGGTCTGTGG GAGAAATCAA AAGGGGACAT CAATCTTGTG 
AAACAAGGGT GCTGGTCTCA CATTGGTGAT CCCCAAGAGT GCCACTATGA AGAATGTGTA 
GTAACTACCA CCCCACCCTC AATTCAGAAT GGAACATACC GTTTTTGCTG CTGTAGTACA 
GACTTATGTA ACGTCAACTT CACTGAGAAC TTCCCACCTC CTGATACAAC ACCACTCAGT 
CCGCCTCATT CATCTAATCG GGATGAAACT ATAATCATTG CTTTGGCATC GGTTTCTGTA 
TTAGCTGTTT TGATAGTCGC CTTATGTTTT GGATACAGAA TGTTGACAGG AGACAGGAAA 
CAGGGTCTAC ACAGTGTGAG CATGATGGAG GCGGCAGCGG CAGAGCCCTC CCTGGACTTG 
GATAACCTGA AGCTGCTGGA GCTGATTGGA CGGGGTCGAT ATGGAGCAGT ATATAAAGGT 
TCCTTGGATG AGCGTCCAGT TGCTGTAAAA GTATTTTCTT TTGCAAACCG TCAGAATTTT 
ATAAATGAAA AAAACATTTA CAGAGTGCCT TTGATGGAAC ATGACAACAT TGCTCGCTTT 
ATAGTTGGAG ACGAGAGGCT CACTGCAGAT GGACGCATGG AGTATTTGCT TGTGATGGAG 
TATTATCCCA ATGGATCTCT GTGCAAATAT CTGAGTCTCC ATACAAGTGA TTGGGTAAGC 
TCTTGCCGTC TGGCTCATTC TGTGACAAGA GGACTGGCTT ATCTTCACAC AGAATTACCC 
CGAGGAGATC ATTACAAACC TGCAATTTCC CATCGAGATT TAAACAGCAG AAATGTCCTG 
GTAAAGAATG GTGGCACGTG TGTTATCAGT GACTTTGGTC TGTCCATGAG GCTAACTGGA 
AACAGGCTGG TGCGCCCAGG GGAAGAAGAT AACGCGGCTA TAAGTGAGGT TGGCACAATC 
CGCTATATGG CACCAGAAGT GCTAGAAGGA GCTGTGAACC TGAGGGACTG TGAGTCAGCA 
CTGAAGCAAG TGGACATGTA TGCGCTTGGA CTGATCTACT GGGAGGTGTT TATGAGGTGC 
ACAGACCTCT TCCCAGGTGA ATCTGTACCA GATTACCAGA TGGCTTTTCA GACAGAAGTT 
GGAAACCATC CCACATTTGA GGATATGCAG GTTCTTGTGT CAAGAGAAAA GCAGAGACCC 
AAGTTCCCAG AAGCCTGGAA AGAAAATAGC CTGGCAGTGA GGTCACTCAA AGAAACAATC 
GAAGACTGCT GGGACCAGGA TGCAGAGGCT CGGCTCACTG CACAGTGTGC TGAGGAGAGA 
ATGGCTGAAC TCATGATGAT ATGGGAGAGA AACAAGTCTG TGAGCCCAAC GGTCAACCCA 
ATGTCGACTG CTATGCAGAA CGAACGCAAC CTATCACATA ATAGGCGTGT GCCAAAAATC 
GGGCCTTACC CAGATTATTC CTCTTCCTCA TATATTGAAG ACTCAATTCA TCACACTGAC 
AGCATTGTGA AAAATATTTC CTCTGAGCAT TCAATGTCCA GCACACCGTT GACAATAGGA 
GAAAAGAACC GAAACTCAAT TAATTATGAA CGACAGCAAG CACAAGCTCG AATCCCTAGC 
CCAGAAACAA GCGTCACAAG CCTGTCCACA AACACAACCA CCACAAACAC CTCTGGCCTC 
ACTCCAAGTA CTGGCATGAC CACGATATCT GAGATGCCAT ACCCAGATGA GACACATTTG 
CATGCCACAA ATGTTGCACA GTCACTCGGG CCAACCCCTG TCTGCTTACA GCTGACAGAA 
GAAGACTTGG AAACTAATAA GCTAGACCCA AAAGAAGTTG ATAAGAACCT CAAGGAAAGC 
TCTGATGAGA ATCTCATGGA GCATTCTCTG AAGCAGTTCA GTGGGCCAGA CCCGTTGAGC 
AGTACCAGTT CCAGCTTGCT TTATCCACTC ATAAAGCTTG CGGTGGAAGT GACTGGACAA 
CAGGACTTCA CACAGGCTGC AAATGGGCAA GCATGTTTAA TTCCTGATGT CCCACCTGCT 
CAGCTCTATC CTCTCCCTAA GCAACAGAAC CTTCCGAAGA GACCTACTAG TTTGCCTTTG 
AACACCAAAA ATTCAACTAA AGAACCCCGG CTAAAATTTG GCAACAAGCA CAAATCAAAC 
TTGAAACAAG TAGAAACTGG AGTTGCCAAG ATGAATACAA TCAATGCAGC AGAGCCTCAT 
GTGGTGACAG TAACTATGAA TGGTGTGGCA GGTAGAAGCC ACAATGTTAA TTCCCATGCT 
GCCACAACCC AGTATGCCAA TGGGGTAGTG CCATCTGGCC AGGCAGCCAA CATAGTGGCA 
CATAGGGCCC AAGAAATGCT GCAGAATCAA TTTAATGGTG AGGATACCAG ACTGAATATC 
AATTCCAGTC CTGATGAACA TGAACCTTTA CTGAGACGAG AGCAGCAGGC TGGCCATGAT 
GAAGGGGTTC TGGATCGTTT GGTAGACAGG AGGGAACGGC CATTAGAAGG TGGCCGAACT 
AATTCCAATA ACAACAACAG CAATCCATGT TCAGAACAAG ATGTCCCTAC ACAAGGTGTT 
ACAAGCACAG CTGCAGACCC TGGGCCAGCA AAGCCCAGAA GAGCACAGAG GCCCAATTCT 
CTGGATCTTT CAGCCACAAA TATCCTGGAT GGCAGCAGCA TGCAGATAGG TGAGTCAACG 
CAGGATGGCA AATCAGGATC AGGCGAAAAG ATCAAGAGAC GTGTGAAAAC TCCATACTCT 
CTTAAGCGGT GGCGCCCATC CACCTGGGTC ATCTCCACCG AGCCACTGGA CTGTGAGGTC 
AACAACAATG GCAGTGACAG GGCAGTCCAT TCTAAATCTA GCACTGCTGT GTACCTCGCA 
GAGGGAGGCA CTGCCACAAC CATGGTGTCT AAAGATATAG GAATGAATTG TCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_536332.1
CDS	373..3489
Translation	MTSSLQRPFRVPWLLWAVLLVSTTAASQNQERLCAFKDPYQQDLGIGESRISHENGTILCSKGSTCYGLWEKSKGDINLVKQGCWSHIGDPQECHYEECVVTTTPPSIQNGTYRFCCCSTDLCNVNFTENFPPPDTTPLSPPHSSNRDETIIIALASVSVLAVLIVALCFGYRMLTGDRKQGLHSVSMMEAAAAEPSLDLDNLKLLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIVGDERLTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNGGTCVISDFGLSMRLTGNRLVRPGEEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEVFMRCTDLFPGESVPDYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIEDCWDQDAEARLTAQCAEERMAELMMIWERNKSVSPTVNPMSTAMQNERNLSHNRRVPKIGPYPDYSSSSYIEDSIHHTDSIVKNISSEHSMSSTPLTIGEKNRNSINYERQQAQARIPSPETSVTSLSTNTTTTNTSGLTPSTGMTTISEMPYPDETHLHATNVAQSLGPTPVCLQLTEEDLETNKLDPKEVDKNLKESSDENLMEHSLKQFSGPDPLSSTSSSLLYPLIKLAVEVTGQQDFTQAANGQACLIPDVPPAQLYPLPKQQNLPKRPTSLPLNTKNSTKEPRLKFGNKHKSNLKQVETGVAKMNTINAAEPHVVTVTMNGVAGRSHNVNSHAATTQYANGVVPSGQAANIVAHRAQEMLQNQFNGEDTRLNINSSPDEHEPLLRREQQAGHDEGVLDRLVDRRERPLEGGRTNSNNNNSNPCSEQDVPTQGVTSTAADPGPAKPRRAQRPNSLDLSATNILDGSSMQIGESTQDGKSGSGEKIKRRVKTPYSLKRWRPSTWVISTEPLDCEVNNNGSDRAVHSKSSTAVYLAEGGTATTMVSKDIGMNCL

Target ORF information:

RefSeq Version	NM_080407.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus bone morphogenetic protein receptor type 2 (Bmpr2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_080407.1

ORF Insert Sequence:

ATGACTTCCT CGCTGCAGCG GCCCTTTCGG GTGCCCTGGC TGTTATGGGC CGTCCTGCTG 
GTCAGCACTA CGGCTGCTTC CCAGAATCAA GAACGGCTGT GTGCATTTAA AGACCCGTAT 
CAACAAGACC TTGGGATTGG TGAGAGTCGA ATCTCTCATG AAAATGGGAC AATATTATGC 
TCCAAAGGGA GCACATGTTA TGGTCTGTGG GAGAAATCAA AAGGGGACAT CAATCTTGTG 
AAACAAGGGT GCTGGTCTCA CATTGGTGAT CCCCAAGAGT GCCACTATGA AGAATGTGTA 
GTAACTACCA CCCCACCCTC AATTCAGAAT GGAACATACC GTTTTTGCTG CTGTAGTACA 
GACTTATGTA ACGTCAACTT CACTGAGAAC TTCCCACCTC CTGATACAAC ACCACTCAGT 
CCGCCTCATT CATCTAATCG GGATGAAACT ATAATCATTG CTTTGGCATC GGTTTCTGTA 
TTAGCTGTTT TGATAGTCGC CTTATGTTTT GGATACAGAA TGTTGACAGG AGACAGGAAA 
CAGGGTCTAC ACAGTGTGAG CATGATGGAG GCGGCAGCGG CAGAGCCCTC CCTGGACTTG 
GATAACCTGA AGCTGCTGGA GCTGATTGGA CGGGGTCGAT ATGGAGCAGT ATATAAAGGT 
TCCTTGGATG AGCGTCCAGT TGCTGTAAAA GTATTTTCTT TTGCAAACCG TCAGAATTTT 
ATAAATGAAA AAAACATTTA CAGAGTGCCT TTGATGGAAC ATGACAACAT TGCTCGCTTT 
ATAGTTGGAG ACGAGAGGCT CACTGCAGAT GGACGCATGG AGTATTTGCT TGTGATGGAG 
TATTATCCCA ATGGATCTCT GTGCAAATAT CTGAGTCTCC ATACAAGTGA TTGGGTAAGC 
TCTTGCCGTC TGGCTCATTC TGTGACAAGA GGACTGGCTT ATCTTCACAC AGAATTACCC 
CGAGGAGATC ATTACAAACC TGCAATTTCC CATCGAGATT TAAACAGCAG AAATGTCCTG 
GTAAAGAATG GTGGCACGTG TGTTATCAGT GACTTTGGTC TGTCCATGAG GCTAACTGGA 
AACAGGCTGG TGCGCCCAGG GGAAGAAGAT AACGCGGCTA TAAGTGAGGT TGGCACAATC 
CGCTATATGG CACCAGAAGT GCTAGAAGGA GCTGTGAACC TGAGGGACTG TGAGTCAGCA 
CTGAAGCAAG TGGACATGTA TGCGCTTGGA CTGATCTACT GGGAGGTGTT TATGAGGTGC 
ACAGACCTCT TCCCAGGTGA ATCTGTACCA GATTACCAGA TGGCTTTTCA GACAGAAGTT 
GGAAACCATC CCACATTTGA GGATATGCAG GTTCTTGTGT CAAGAGAAAA GCAGAGACCC 
AAGTTCCCAG AAGCCTGGAA AGAAAATAGC CTGGCAGTGA GGTCACTCAA AGAAACAATC 
GAAGACTGCT GGGACCAGGA TGCAGAGGCT CGGCTCACTG CACAGTGTGC TGAGGAGAGA 
ATGGCTGAAC TCATGATGAT ATGGGAGAGA AACAAGTCTG TGAGCCCAAC GGTCAACCCA 
ATGTCGACTG CTATGCAGAA CGAACGCAAC CTATCACATA ATAGGCGTGT GCCAAAAATC 
GGGCCTTACC CAGATTATTC CTCTTCCTCA TATATTGAAG ACTCAATTCA TCACACTGAC 
AGCATTGTGA AAAATATTTC CTCTGAGCAT TCAATGTCCA GCACACCGTT GACAATAGGA 
GAAAAGAACC GAAACTCAAT TAATTATGAA CGACAGCAAG CACAAGCTCG AATCCCTAGC 
CCAGAAACAA GCGTCACAAG CCTGTCCACA AACACAACCA CCACAAACAC CTCTGGCCTC 
ACTCCAAGTA CTGGCATGAC CACGATATCT GAGATGCCAT ACCCAGATGA GACACATTTG 
CATGCCACAA ATGTTGCACA GTCACTCGGG CCAACCCCTG TCTGCTTACA GCTGACAGAA 
GAAGACTTGG AAACTAATAA GCTAGACCCA AAAGAAGTTG ATAAGAACCT CAAGGAAAGC 
TCTGATGAGA ATCTCATGGA GCATTCTCTG AAGCAGTTCA GTGGGCCAGA CCCGTTGAGC 
AGTACCAGTT CCAGCTTGCT TTATCCACTC ATAAAGCTTG CGGTGGAAGT GACTGGACAA 
CAGGACTTCA CACAGGCTGC AAATGGGCAA GCATGTTTAA TTCCTGATGT CCCACCTGCT 
CAGCTCTATC CTCTCCCTAA GCAACAGAAC CTTCCGAAGA GACCTACTAG TTTGCCTTTG 
AACACCAAAA ATTCAACTAA AGAACCCCGG CTAAAATTTG GCAACAAGCA CAAATCAAAC 
TTGAAACAAG TAGAAACTGG AGTTGCCAAG ATGAATACAA TCAATGCAGC AGAGCCTCAT 
GTGGTGACAG TAACTATGAA TGGTGTGGCA GGTAGAAGCC ACAATGTTAA TTCCCATGCT 
GCCACAACCC AGTATGCCAA TGGGGTAGTG CCATCTGGCC AGGCAGCCAA CATAGTGGCA 
CATAGGGCCC AAGAAATGCT GCAGAATCAA TTTAATGGTG AGGATACCAG ACTGAATATC 
AATTCCAGTC CTGATGAACA TGAACCTTTA CTGAGACGAG AGCAGCAGGC TGGCCATGAT 
GAAGGGGTTC TGGATCGTTT GGTAGACAGG AGGGAACGGC CATTAGAAGG TGGCCGAACT 
AATTCCAATA ACAACAACAG CAATCCATGT TCAGAACAAG ATGTCCCTAC ACAAGGTGTT 
ACAAGCACAG CTGCAGACCC TGGGCCAGCA AAGCCCAGAA GAGCACAGAG GCCCAATTCT 
CTGGATCTTT CAGCCACAAA TATCCTGGAT GGCAGCAGCA TGCAGATAGG TGAGTCAACG 
CAGGATGGCA AATCAGGATC AGGCGAAAAG ATCAAGAGAC GTGTGAAAAC TCCATACTCT 
CTTAAGCGGT GGCGCCCATC CACCTGGGTC ATCTCCACCG AGCCACTGGA CTGTGAGGTC 
AACAACAATG GCAGTGACAG GGCAGTCCAT TCTAAATCTA GCACTGCTGT GTACCTCGCA 
GAGGGAGGCA CTGCCACAAC CATGGTGTCT AAAGATATAG GAATGAATTG TCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Bmpr2 ( XM_006244951.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006245013.1 Rattus norvegicus bone morphogenetic protein receptor type 2 (Bmpr2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa32217
Clone ID Related Accession (Same CDS sequence)	XM_006244951.3
Accession Version	XM_006244951.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3159bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	bone morphogenetic protein receptor type-2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005108.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006244951.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACTTCCT CGCTGCAGCG GCCCTTTCGG GTGCCCTGGC TGTTATGGGC CGTCCTGCTG 
GTCAGCACTA CGGCTGAACT CTTGAACATC CTCAGCCTCC AACGTGCTGG AATTACAGCT 
TCCCAGAATC AAGAACGGCT GTGTGCATTT AAAGACCCGT ATCAACAAGA CCTTGGGATT 
GGTGAGAGTC GAATCTCTCA TGAAAATGGG ACAATATTAT GCTCCAAAGG GAGCACATGT 
TATGGTCTGT GGGAGAAATC AAAAGGGGAC ATCAATCTTG TGAAACAAGG GTGCTGGTCT 
CACATTGGTG ATCCCCAAGA GTGCCACTAT GAAGAATGTG TAGTAACTAC CACCCCACCC 
TCAATTCAGA ATGGAACATA CCGTTTTTGC TGCTGTAGTA CAGACTTATG TAACGTCAAC 
TTCACTGAGA ACTTCCCACC TCCTGATACA ACACCACTCA GTCCGCCTCA TTCATCTAAT 
CGGGATGAAA CTATAATCAT TGCTTTGGCA TCGGTTTCTG TATTAGCTGT TTTGATAGTC 
GCCTTATGTT TTGGATACAG AATGTTGACA GGAGACAGGA AACAGGGTCT ACACAGTGTG 
AGCATGATGG AGGCGGCAGC GGCAGAGCCC TCCCTGGACT TGGATAACCT GAAGCTGCTG 
GAGCTGATTG GACGGGGTCG ATATGGAGCA GTATATAAAG GTTCCTTGGA TGAGCGTCCA 
GTTGCTGTAA AAGTATTTTC TTTTGCAAAC CGTCAGAATT TTATAAATGA AAAAAACATT 
TACAGAGTGC CTTTGATGGA ACATGACAAC ATTGCTCGCT TTATAGTTGG AGACGAGAGG 
CTCACTGCAG ATGGACGCAT GGAGTATTTG CTTGTGATGG AGTATTATCC CAATGGATCT 
CTGTGCAAAT ATCTGAGTCT CCATACAAGT GATTGGGTAA GCTCTTGCCG TCTGGCTCAT 
TCTGTGACAA GAGGACTGGC TTATCTTCAC ACAGAATTAC CCCGAGGAGA TCATTACAAA 
CCTGCAATTT CCCATCGAGA TTTAAACAGC AGAAATGTCC TGGTAAAGAA TGGTGGCACG 
TGTGTTATCA GTGACTTTGG TCTGTCCATG AGGCTAACTG GAAACAGGCT GGTGCGCCCA 
GGGGAAGAAG ATAACGCGGC TATAAGTGAG GTTGGCACAA TCCGCTATAT GGCACCAGAA 
GTGCTAGAAG GAGCTGTGAA CCTGAGGGAC TGTGAGTCAG CACTGAAGCA AGTGGACATG 
TATGCGCTTG GACTGATCTA CTGGGAGGTG TTTATGAGGT GCACAGACCT CTTCCCAGGT 
GAATCTGTAC CAGATTACCA GATGGCTTTT CAGACAGAAG TTGGAAACCA TCCCACATTT 
GAGGATATGC AGGTTCTTGT GTCAAGAGAA AAGCAGAGAC CCAAGTTCCC AGAAGCCTGG 
AAAGAAAATA GCCTGGCAGT GAGGTCACTC AAAGAAACAA TCGAAGACTG CTGGGACCAG 
GATGCAGAGG CTCGGCTCAC TGCACAGTGT GCTGAGGAGA GAATGGCTGA ACTCATGATG 
ATATGGGAGA GAAACAAGTC TGTGAGCCCA ACGGTCAACC CAATGTCGAC TGCTATGCAG 
AACGAACGCA ACCTATCACA TAATAGGCGT GTGCCAAAAA TCGGGCCTTA CCCAGATTAT 
TCCTCTTCCT CATATATTGA AGACTCAATT CATCACACTG ACAGCATTGT GAAAAATATT 
TCCTCTGAGC ATTCAATGTC CAGCACACCG TTGACAATAG GAGAAAAGAA CCGAAACTCA 
ATTAATTATG AACGACAGCA AGCACAAGCT CGAATCCCTA GCCCAGAAAC AAGCGTCACA 
AGCCTGTCCA CAAACACAAC CACCACAAAC ACCTCTGGCC TCACTCCAAG TACTGGCATG 
ACCACGATAT CTGAGATGCC ATACCCAGAT GAGACACATT TGCATGCCAC AAATGTTGCA 
CAGTCACTCG GGCCAACCCC TGTCTGCTTA CAGCTGACAG AAGAAGACTT GGAAACTAAT 
AAGCTAGACC CAAAAGAAGT TGATAAGAAC CTCAAGGAAA GCTCTGATGA GAATCTCATG 
GAGCATTCTC TGAAGCAGTT CAGTGGGCCA GACCCGTTGA GCAGTACCAG TTCCAGCTTG 
CTTTATCCAC TCATAAAGCT TGCGGTGGAA GTGACTGGAC AACAGGACTT CACACAGGCT 
GCAAATGGGC AAGCATGTTT AATTCCTGAT GTCCCACCTG CTCAGCTCTA TCCTCTCCCT 
AAGCAACAGA ACCTTCCGAA GAGACCTACT AGTTTGCCTT TGAACACCAA AAATTCAACT 
AAAGAACCCC GGCTAAAATT TGGCAACAAG CACAAATCAA ACTTGAAACA AGTAGAAACT 
GGAGTTGCCA AGATGAATAC AATCAATGCA GCAGAGCCTC ATGTGGTGAC AGTAACTATG 
AATGGTGTGG CAGGTAGAAG CCACAATGTT AATTCCCATG CTGCCACAAC CCAGTATGCC 
AATGGGGTAG TGCCATCTGG CCAGGCAGCC AACATAGTGG CACATAGGGC CCAAGAAATG 
CTGCAGAATC AATTTAATGG TGAGGATACC AGACTGAATA TCAATTCCAG TCCTGATGAA 
CATGAACCTT TACTGAGACG AGAGCAGCAG GCTGGCCATG ATGAAGGGGT TCTGGATCGT 
TTGGTAGACA GGAGGGAACG GCCATTAGAA GGTGGCCGAA CTAATTCCAA TAACAACAAC 
AGCAATCCAT GTTCAGAACA AGATGTCCCT ACACAAGGTG TTACAAGCAC AGCTGCAGAC 
CCTGGGCCAG CAAAGCCCAG AAGAGCACAG AGGCCCAATT CTCTGGATCT TTCAGCCACA 
AATATCCTGG ATGGCAGCAG CATGCAGATA GGTGAGTCAA CGCAGGATGG CAAATCAGGA 
TCAGGCGAAA AGATCAAGAG ACGTGTGAAA ACTCCATACT CTCTTAAGCG GTGGCGCCCA 
TCCACCTGGG TCATCTCCAC CGAGCCACTG GACTGTGAGG TCAACAACAA TGGCAGTGAC 
AGGGCAGTCC ATTCTAAATC TAGCACTGCT GTGTACCTCG CAGAGGGAGG CACTGCCACA 
ACCATGGTGT CTAAAGATAT AGGAATGAAT TGTCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006245013.1
CDS	20..3178
Translation	MTSSLQRPFRVPWLLWAVLLVSTTAELLNILSLQRAGITASQNQERLCAFKDPYQQDLGIGESRISHENGTILCSKGSTCYGLWEKSKGDINLVKQGCWSHIGDPQECHYEECVVTTTPPSIQNGTYRFCCCSTDLCNVNFTENFPPPDTTPLSPPHSSNRDETIIIALASVSVLAVLIVALCFGYRMLTGDRKQGLHSVSMMEAAAAEPSLDLDNLKLLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIVGDERLTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNGGTCVISDFGLSMRLTGNRLVRPGEEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEVFMRCTDLFPGESVPDYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIEDCWDQDAEARLTAQCAEERMAELMMIWERNKSVSPTVNPMSTAMQNERNLSHNRRVPKIGPYPDYSSSSYIEDSIHHTDSIVKNISSEHSMSSTPLTIGEKNRNSINYERQQAQARIPSPETSVTSLSTNTTTTNTSGLTPSTGMTTISEMPYPDETHLHATNVAQSLGPTPVCLQLTEEDLETNKLDPKEVDKNLKESSDENLMEHSLKQFSGPDPLSSTSSSLLYPLIKLAVEVTGQQDFTQAANGQACLIPDVPPAQLYPLPKQQNLPKRPTSLPLNTKNSTKEPRLKFGNKHKSNLKQVETGVAKMNTINAAEPHVVTVTMNGVAGRSHNVNSHAATTQYANGVVPSGQAANIVAHRAQEMLQNQFNGEDTRLNINSSPDEHEPLLRREQQAGHDEGVLDRLVDRRERPLEGGRTNSNNNNSNPCSEQDVPTQGVTSTAADPGPAKPRRAQRPNSLDLSATNILDGSSMQIGESTQDGKSGSGEKIKRRVKTPYSLKRWRPSTWVISTEPLDCEVNNNGSDRAVHSKSSTAVYLAEGGTATTMVSKDIGMNCL

Target ORF information:

RefSeq Version	XM_006244951.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus bone morphogenetic protein receptor type 2 (Bmpr2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006244951.3

ORF Insert Sequence:

ATGACTTCCT CGCTGCAGCG GCCCTTTCGG GTGCCCTGGC TGTTATGGGC CGTCCTGCTG 
GTCAGCACTA CGGCTGAACT CTTGAACATC CTCAGCCTCC AACGTGCTGG AATTACAGCT 
TCCCAGAATC AAGAACGGCT GTGTGCATTT AAAGACCCGT ATCAACAAGA CCTTGGGATT 
GGTGAGAGTC GAATCTCTCA TGAAAATGGG ACAATATTAT GCTCCAAAGG GAGCACATGT 
TATGGTCTGT GGGAGAAATC AAAAGGGGAC ATCAATCTTG TGAAACAAGG GTGCTGGTCT 
CACATTGGTG ATCCCCAAGA GTGCCACTAT GAAGAATGTG TAGTAACTAC CACCCCACCC 
TCAATTCAGA ATGGAACATA CCGTTTTTGC TGCTGTAGTA CAGACTTATG TAACGTCAAC 
TTCACTGAGA ACTTCCCACC TCCTGATACA ACACCACTCA GTCCGCCTCA TTCATCTAAT 
CGGGATGAAA CTATAATCAT TGCTTTGGCA TCGGTTTCTG TATTAGCTGT TTTGATAGTC 
GCCTTATGTT TTGGATACAG AATGTTGACA GGAGACAGGA AACAGGGTCT ACACAGTGTG 
AGCATGATGG AGGCGGCAGC GGCAGAGCCC TCCCTGGACT TGGATAACCT GAAGCTGCTG 
GAGCTGATTG GACGGGGTCG ATATGGAGCA GTATATAAAG GTTCCTTGGA TGAGCGTCCA 
GTTGCTGTAA AAGTATTTTC TTTTGCAAAC CGTCAGAATT TTATAAATGA AAAAAACATT 
TACAGAGTGC CTTTGATGGA ACATGACAAC ATTGCTCGCT TTATAGTTGG AGACGAGAGG 
CTCACTGCAG ATGGACGCAT GGAGTATTTG CTTGTGATGG AGTATTATCC CAATGGATCT 
CTGTGCAAAT ATCTGAGTCT CCATACAAGT GATTGGGTAA GCTCTTGCCG TCTGGCTCAT 
TCTGTGACAA GAGGACTGGC TTATCTTCAC ACAGAATTAC CCCGAGGAGA TCATTACAAA 
CCTGCAATTT CCCATCGAGA TTTAAACAGC AGAAATGTCC TGGTAAAGAA TGGTGGCACG 
TGTGTTATCA GTGACTTTGG TCTGTCCATG AGGCTAACTG GAAACAGGCT GGTGCGCCCA 
GGGGAAGAAG ATAACGCGGC TATAAGTGAG GTTGGCACAA TCCGCTATAT GGCACCAGAA 
GTGCTAGAAG GAGCTGTGAA CCTGAGGGAC TGTGAGTCAG CACTGAAGCA AGTGGACATG 
TATGCGCTTG GACTGATCTA CTGGGAGGTG TTTATGAGGT GCACAGACCT CTTCCCAGGT 
GAATCTGTAC CAGATTACCA GATGGCTTTT CAGACAGAAG TTGGAAACCA TCCCACATTT 
GAGGATATGC AGGTTCTTGT GTCAAGAGAA AAGCAGAGAC CCAAGTTCCC AGAAGCCTGG 
AAAGAAAATA GCCTGGCAGT GAGGTCACTC AAAGAAACAA TCGAAGACTG CTGGGACCAG 
GATGCAGAGG CTCGGCTCAC TGCACAGTGT GCTGAGGAGA GAATGGCTGA ACTCATGATG 
ATATGGGAGA GAAACAAGTC TGTGAGCCCA ACGGTCAACC CAATGTCGAC TGCTATGCAG 
AACGAACGCA ACCTATCACA TAATAGGCGT GTGCCAAAAA TCGGGCCTTA CCCAGATTAT 
TCCTCTTCCT CATATATTGA AGACTCAATT CATCACACTG ACAGCATTGT GAAAAATATT 
TCCTCTGAGC ATTCAATGTC CAGCACACCG TTGACAATAG GAGAAAAGAA CCGAAACTCA 
ATTAATTATG AACGACAGCA AGCACAAGCT CGAATCCCTA GCCCAGAAAC AAGCGTCACA 
AGCCTGTCCA CAAACACAAC CACCACAAAC ACCTCTGGCC TCACTCCAAG TACTGGCATG 
ACCACGATAT CTGAGATGCC ATACCCAGAT GAGACACATT TGCATGCCAC AAATGTTGCA 
CAGTCACTCG GGCCAACCCC TGTCTGCTTA CAGCTGACAG AAGAAGACTT GGAAACTAAT 
AAGCTAGACC CAAAAGAAGT TGATAAGAAC CTCAAGGAAA GCTCTGATGA GAATCTCATG 
GAGCATTCTC TGAAGCAGTT CAGTGGGCCA GACCCGTTGA GCAGTACCAG TTCCAGCTTG 
CTTTATCCAC TCATAAAGCT TGCGGTGGAA GTGACTGGAC AACAGGACTT CACACAGGCT 
GCAAATGGGC AAGCATGTTT AATTCCTGAT GTCCCACCTG CTCAGCTCTA TCCTCTCCCT 
AAGCAACAGA ACCTTCCGAA GAGACCTACT AGTTTGCCTT TGAACACCAA AAATTCAACT 
AAAGAACCCC GGCTAAAATT TGGCAACAAG CACAAATCAA ACTTGAAACA AGTAGAAACT 
GGAGTTGCCA AGATGAATAC AATCAATGCA GCAGAGCCTC ATGTGGTGAC AGTAACTATG 
AATGGTGTGG CAGGTAGAAG CCACAATGTT AATTCCCATG CTGCCACAAC CCAGTATGCC 
AATGGGGTAG TGCCATCTGG CCAGGCAGCC AACATAGTGG CACATAGGGC CCAAGAAATG 
CTGCAGAATC AATTTAATGG TGAGGATACC AGACTGAATA TCAATTCCAG TCCTGATGAA 
CATGAACCTT TACTGAGACG AGAGCAGCAG GCTGGCCATG ATGAAGGGGT TCTGGATCGT 
TTGGTAGACA GGAGGGAACG GCCATTAGAA GGTGGCCGAA CTAATTCCAA TAACAACAAC 
AGCAATCCAT GTTCAGAACA AGATGTCCCT ACACAAGGTG TTACAAGCAC AGCTGCAGAC 
CCTGGGCCAG CAAAGCCCAG AAGAGCACAG AGGCCCAATT CTCTGGATCT TTCAGCCACA 
AATATCCTGG ATGGCAGCAG CATGCAGATA GGTGAGTCAA CGCAGGATGG CAAATCAGGA 
TCAGGCGAAA AGATCAAGAG ACGTGTGAAA ACTCCATACT CTCTTAAGCG GTGGCGCCCA 
TCCACCTGGG TCATCTCCAC CGAGCCACTG GACTGTGAGG TCAACAACAA TGGCAGTGAC 
AGGGCAGTCC ATTCTAAATC TAGCACTGCT GTGTACCTCG CAGAGGGAGG CACTGCCACA 
ACCATGGTGT CTAAAGATAT AGGAATGAAT TGTCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Bmpr2 ( XM_006244952.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006245014.1 Rattus norvegicus bone morphogenetic protein receptor type 2 (Bmpr2), transcript variant X2, mRNA.

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CloneID	ORa32218
Clone ID Related Accession (Same CDS sequence)	XM_006244952.3
Accession Version	XM_006244952.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3156bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	bone morphogenetic protein receptor type-2 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005108.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006244952.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACTTCCT CGCTGCAGCG GCCCTTTCGG GTGCCCTGGC TGTTATGGGC CGTCCTGCTG 
GTCAGCACTA CGGCTGAACT CTTGAACATC CTCAGCCTCC AACGTGCTGG AATTACAGCT 
TCCCAGAATC AAGAACGGCT GTGTGCATTT AAAGACCCGT ATCAACAAGA CCTTGGGATT 
GGTGAGAGTC GAATCTCTCA TGAAAATGGG ACAATATTAT GCTCCAAAGG GAGCACATGT 
TATGGTCTGT GGGAGAAATC AAAAGGGGAC ATCAATCTTG TGAAACAAGG GTGCTGGTCT 
CACATTGGTG ATCCCCAAGA GTGCCACTAT GAAGAATGTG TAGTAACTAC CACCCCACCC 
TCAATTCAGA ATGGAACATA CCGTTTTTGC TGCTGTAGTA CAGACTTATG TAACGTCAAC 
TTCACTGAGA ACTTCCCACC TCCTGATACA ACACCACTCA GTCCGCCTCA TTCATCTAAT 
CGGGATGAAA CTATAATCAT TGCTTTGGCA TCGGTTTCTG TATTAGCTGT TTTGATAGTC 
GCCTTATGTT TTGGATACAG AATGTTGACA GGAGACAGGA AACAGGGTCT ACACAGTGTG 
AGCATGATGG AGGCGGCAGC GGCAGAGCCC TCCCTGGACT TGGATAACCT GAAGCTGCTG 
GAGCTGATTG GACGGGGTCG ATATGGAGCA GTATATAAAG GTTCCTTGGA TGAGCGTCCA 
GTTGCTGTAA AAGTATTTTC TTTTGCAAAC CGTCAGAATT TTATAAATGA AAAAAACATT 
TACAGAGTGC CTTTGATGGA ACATGACAAC ATTGCTCGCT TTATAGTTGG AGACGAGAGG 
CTCACTGCAG ATGGACGCAT GGAGTATTTG CTTGTGATGG AGTATTATCC CAATGGATCT 
CTGTGCAAAT ATCTGAGTCT CCATACAAGT GATTGGGTAA GCTCTTGCCG TCTGGCTCAT 
TCTGTGACAA GAGGACTGGC TTATCTTCAC ACAGAATTAC CCCGAGGAGA TCATTACAAA 
CCTGCAATTT CCCATCGAGA TTTAAACAGC AGAAATGTCC TGGTAAAGAA TGGTGGCACG 
TGTGTTATCA GTGACTTTGG TCTGTCCATG AGGCTAACTG GAAACAGGCT GGTGCGCCCA 
GGGGAAGAAG ATAACGCGGC TATAAGTGAG GTTGGCACAA TCCGCTATAT GGCACCAGAA 
GTGCTAGAAG GAGCTGTGAA CCTGAGGGAC TGTGAGTCAG CACTGAAGCA AGTGGACATG 
TATGCGCTTG GACTGATCTA CTGGGAGGTG TTTATGAGGT GCACAGACCT CTTCCCAGGT 
GAATCTGTAC CAGATTACCA GATGGCTTTT CAGACAGAAG TTGGAAACCA TCCCACATTT 
GAGGATATGC AGGTTCTTGT GTCAAGAGAA AAGCAGAGAC CCAAGTTCCC AGAAGCCTGG 
AAAGAAAATA GCCTGGCAGT GAGGTCACTC AAAGAAACAA TCGAAGACTG CTGGGACCAG 
GATGCAGAGG CTCGGCTCAC TGCACAGTGT GCTGAGGAGA GAATGGCTGA ACTCATGATG 
ATATGGGAGA GAAACAAGTC TGTGAGCCCA ACGGTCAACC CAATGTCGAC TGCTATGCAG 
AACGAACGCA ACCTATCACA TAATAGGCGT GTGCCAAAAA TCGGGCCTTA CCCAGATTAT 
TCCTCTTCCT CATATATTGA AGACTCAATT CATCACACTG ACAGCATTGT GAAAAATATT 
TCCTCTGAGC ATTCAATGTC CAGCACACCG TTGACAATAG GAGAAAAGAA CCGAAACTCA 
ATTAATTATG AACGACAGCA AGCACAAGCT CGAATCCCTA GCCCAGAAAC AAGCGTCACA 
AGCCTGTCCA CAAACACAAC CACCACAAAC ACCTCTGGCC TCACTCCAAG TACTGGCATG 
ACCACGATAT CTGAGATGCC ATACCCAGAT GAGACACATT TGCATGCCAC AAATGTTGCA 
CAGTCACTCG GGCCAACCCC TGTCTGCTTA CAGCTGACAG AAGAAGACTT GGAAACTAAT 
AAGCTAGACC CAAAAGAAGT TGATAAGAAC CTCAAGGAAA GCTCTGATGA GAATCTCATG 
GAGCATTCTC TGAAGCAGTT CAGTGGGCCA GACCCGTTGA GCAGTACCAG TTCCAGCTTG 
CTTTATCCAC TCATAAAGCT TGCGGTGGAA GTGACTGGAC AACAGGACTT CACACAGGCT 
GCAAATGGGC AAGCATGTTT AATTCCTGAT GTCCCACCTG CTCAGCTCTA TCCTCTCCCT 
AAGCAACAGA ACCTTCCGAA GAGACCTACT AGTTTGCCTT TGAACACCAA AAATTCAACT 
AAAGAACCCC GGCTAAAATT TGGCAACAAG CACAAATCAA ACTTGAAACA AGTAGAAACT 
GGAGTTGCCA AGATGAATAC AATCAATGCA GCAGAGCCTC ATGTGGTGAC AGTAACTATG 
AATGGTGTGG CAGGTAGAAG CCACAATGTT AATTCCCATG CTGCCACAAC CCAGTATGCC 
AATGGGGTAG TGCCATCTGG CCAGGCAGCC AACATAGTGG CACATAGGGC CCAAGAAATG 
CTGCAGAATC AATTTAATGG TGAGGATACC AGACTGAATA TCAATTCCAG TCCTGATGAA 
CATGAACCTT TACTGAGACG AGAGCAGCAG GCTGGCCATG ATGAAGGGGT TCTGGATCGT 
TTGGTAGACA GGAGGGAACG GCCATTAGAA GGTGGCCGAA CTAATTCCAA TAACAACAAC 
AGCAATCCAT GTTCAGAACA AGATGTCCCT ACACAAGGTG TTACAAGCAC AGCTGCAGAC 
CCTGGGCCAG CAAAGCCCAG AAGAGCACAG AGGCCCAATT CTCTGGATCT TTCAGCCACA 
AATATCCTGG ATGGCAGCAG CATGCAGAGT GAGTCAACGC AGGATGGCAA ATCAGGATCA 
GGCGAAAAGA TCAAGAGACG TGTGAAAACT CCATACTCTC TTAAGCGGTG GCGCCCATCC 
ACCTGGGTCA TCTCCACCGA GCCACTGGAC TGTGAGGTCA ACAACAATGG CAGTGACAGG 
GCAGTCCATT CTAAATCTAG CACTGCTGTG TACCTCGCAG AGGGAGGCAC TGCCACAACC 
ATGGTGTCTA AAGATATAGG AATGAATTGT CTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006245014.1
CDS	20..3175
Translation	MTSSLQRPFRVPWLLWAVLLVSTTAELLNILSLQRAGITASQNQERLCAFKDPYQQDLGIGESRISHENGTILCSKGSTCYGLWEKSKGDINLVKQGCWSHIGDPQECHYEECVVTTTPPSIQNGTYRFCCCSTDLCNVNFTENFPPPDTTPLSPPHSSNRDETIIIALASVSVLAVLIVALCFGYRMLTGDRKQGLHSVSMMEAAAAEPSLDLDNLKLLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIVGDERLTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNGGTCVISDFGLSMRLTGNRLVRPGEEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEVFMRCTDLFPGESVPDYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIEDCWDQDAEARLTAQCAEERMAELMMIWERNKSVSPTVNPMSTAMQNERNLSHNRRVPKIGPYPDYSSSSYIEDSIHHTDSIVKNISSEHSMSSTPLTIGEKNRNSINYERQQAQARIPSPETSVTSLSTNTTTTNTSGLTPSTGMTTISEMPYPDETHLHATNVAQSLGPTPVCLQLTEEDLETNKLDPKEVDKNLKESSDENLMEHSLKQFSGPDPLSSTSSSLLYPLIKLAVEVTGQQDFTQAANGQACLIPDVPPAQLYPLPKQQNLPKRPTSLPLNTKNSTKEPRLKFGNKHKSNLKQVETGVAKMNTINAAEPHVVTVTMNGVAGRSHNVNSHAATTQYANGVVPSGQAANIVAHRAQEMLQNQFNGEDTRLNINSSPDEHEPLLRREQQAGHDEGVLDRLVDRRERPLEGGRTNSNNNNSNPCSEQDVPTQGVTSTAADPGPAKPRRAQRPNSLDLSATNILDGSSMQSESTQDGKSGSGEKIKRRVKTPYSLKRWRPSTWVISTEPLDCEVNNNGSDRAVHSKSSTAVYLAEGGTATTMVSKDIGMNCL

Target ORF information:

RefSeq Version	XM_006244952.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus bone morphogenetic protein receptor type 2 (Bmpr2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006244952.3

ORF Insert Sequence:

ATGACTTCCT CGCTGCAGCG GCCCTTTCGG GTGCCCTGGC TGTTATGGGC CGTCCTGCTG 
GTCAGCACTA CGGCTGAACT CTTGAACATC CTCAGCCTCC AACGTGCTGG AATTACAGCT 
TCCCAGAATC AAGAACGGCT GTGTGCATTT AAAGACCCGT ATCAACAAGA CCTTGGGATT 
GGTGAGAGTC GAATCTCTCA TGAAAATGGG ACAATATTAT GCTCCAAAGG GAGCACATGT 
TATGGTCTGT GGGAGAAATC AAAAGGGGAC ATCAATCTTG TGAAACAAGG GTGCTGGTCT 
CACATTGGTG ATCCCCAAGA GTGCCACTAT GAAGAATGTG TAGTAACTAC CACCCCACCC 
TCAATTCAGA ATGGAACATA CCGTTTTTGC TGCTGTAGTA CAGACTTATG TAACGTCAAC 
TTCACTGAGA ACTTCCCACC TCCTGATACA ACACCACTCA GTCCGCCTCA TTCATCTAAT 
CGGGATGAAA CTATAATCAT TGCTTTGGCA TCGGTTTCTG TATTAGCTGT TTTGATAGTC 
GCCTTATGTT TTGGATACAG AATGTTGACA GGAGACAGGA AACAGGGTCT ACACAGTGTG 
AGCATGATGG AGGCGGCAGC GGCAGAGCCC TCCCTGGACT TGGATAACCT GAAGCTGCTG 
GAGCTGATTG GACGGGGTCG ATATGGAGCA GTATATAAAG GTTCCTTGGA TGAGCGTCCA 
GTTGCTGTAA AAGTATTTTC TTTTGCAAAC CGTCAGAATT TTATAAATGA AAAAAACATT 
TACAGAGTGC CTTTGATGGA ACATGACAAC ATTGCTCGCT TTATAGTTGG AGACGAGAGG 
CTCACTGCAG ATGGACGCAT GGAGTATTTG CTTGTGATGG AGTATTATCC CAATGGATCT 
CTGTGCAAAT ATCTGAGTCT CCATACAAGT GATTGGGTAA GCTCTTGCCG TCTGGCTCAT 
TCTGTGACAA GAGGACTGGC TTATCTTCAC ACAGAATTAC CCCGAGGAGA TCATTACAAA 
CCTGCAATTT CCCATCGAGA TTTAAACAGC AGAAATGTCC TGGTAAAGAA TGGTGGCACG 
TGTGTTATCA GTGACTTTGG TCTGTCCATG AGGCTAACTG GAAACAGGCT GGTGCGCCCA 
GGGGAAGAAG ATAACGCGGC TATAAGTGAG GTTGGCACAA TCCGCTATAT GGCACCAGAA 
GTGCTAGAAG GAGCTGTGAA CCTGAGGGAC TGTGAGTCAG CACTGAAGCA AGTGGACATG 
TATGCGCTTG GACTGATCTA CTGGGAGGTG TTTATGAGGT GCACAGACCT CTTCCCAGGT 
GAATCTGTAC CAGATTACCA GATGGCTTTT CAGACAGAAG TTGGAAACCA TCCCACATTT 
GAGGATATGC AGGTTCTTGT GTCAAGAGAA AAGCAGAGAC CCAAGTTCCC AGAAGCCTGG 
AAAGAAAATA GCCTGGCAGT GAGGTCACTC AAAGAAACAA TCGAAGACTG CTGGGACCAG 
GATGCAGAGG CTCGGCTCAC TGCACAGTGT GCTGAGGAGA GAATGGCTGA ACTCATGATG 
ATATGGGAGA GAAACAAGTC TGTGAGCCCA ACGGTCAACC CAATGTCGAC TGCTATGCAG 
AACGAACGCA ACCTATCACA TAATAGGCGT GTGCCAAAAA TCGGGCCTTA CCCAGATTAT 
TCCTCTTCCT CATATATTGA AGACTCAATT CATCACACTG ACAGCATTGT GAAAAATATT 
TCCTCTGAGC ATTCAATGTC CAGCACACCG TTGACAATAG GAGAAAAGAA CCGAAACTCA 
ATTAATTATG AACGACAGCA AGCACAAGCT CGAATCCCTA GCCCAGAAAC AAGCGTCACA 
AGCCTGTCCA CAAACACAAC CACCACAAAC ACCTCTGGCC TCACTCCAAG TACTGGCATG 
ACCACGATAT CTGAGATGCC ATACCCAGAT GAGACACATT TGCATGCCAC AAATGTTGCA 
CAGTCACTCG GGCCAACCCC TGTCTGCTTA CAGCTGACAG AAGAAGACTT GGAAACTAAT 
AAGCTAGACC CAAAAGAAGT TGATAAGAAC CTCAAGGAAA GCTCTGATGA GAATCTCATG 
GAGCATTCTC TGAAGCAGTT CAGTGGGCCA GACCCGTTGA GCAGTACCAG TTCCAGCTTG 
CTTTATCCAC TCATAAAGCT TGCGGTGGAA GTGACTGGAC AACAGGACTT CACACAGGCT 
GCAAATGGGC AAGCATGTTT AATTCCTGAT GTCCCACCTG CTCAGCTCTA TCCTCTCCCT 
AAGCAACAGA ACCTTCCGAA GAGACCTACT AGTTTGCCTT TGAACACCAA AAATTCAACT 
AAAGAACCCC GGCTAAAATT TGGCAACAAG CACAAATCAA ACTTGAAACA AGTAGAAACT 
GGAGTTGCCA AGATGAATAC AATCAATGCA GCAGAGCCTC ATGTGGTGAC AGTAACTATG 
AATGGTGTGG CAGGTAGAAG CCACAATGTT AATTCCCATG CTGCCACAAC CCAGTATGCC 
AATGGGGTAG TGCCATCTGG CCAGGCAGCC AACATAGTGG CACATAGGGC CCAAGAAATG 
CTGCAGAATC AATTTAATGG TGAGGATACC AGACTGAATA TCAATTCCAG TCCTGATGAA 
CATGAACCTT TACTGAGACG AGAGCAGCAG GCTGGCCATG ATGAAGGGGT TCTGGATCGT 
TTGGTAGACA GGAGGGAACG GCCATTAGAA GGTGGCCGAA CTAATTCCAA TAACAACAAC 
AGCAATCCAT GTTCAGAACA AGATGTCCCT ACACAAGGTG TTACAAGCAC AGCTGCAGAC 
CCTGGGCCAG CAAAGCCCAG AAGAGCACAG AGGCCCAATT CTCTGGATCT TTCAGCCACA 
AATATCCTGG ATGGCAGCAG CATGCAGAGT GAGTCAACGC AGGATGGCAA ATCAGGATCA 
GGCGAAAAGA TCAAGAGACG TGTGAAAACT CCATACTCTC TTAAGCGGTG GCGCCCATCC 
ACCTGGGTCA TCTCCACCGA GCCACTGGAC TGTGAGGTCA ACAACAATGG CAGTGACAGG 
GCAGTCCATT CTAAATCTAG CACTGCTGTG TACCTCGCAG AGGGAGGCAC TGCCACAACC 
ATGGTGTCTA AAGATATAGG AATGAATTGT CTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Bmpr2 Mutant Rats Develop Pulmonary and Cardiac Characteristics of Pulmonary Arterial Hypertension.
Circulation139(7)932-948(2019 02)
Hautefort A,Mendes-Ferreira P,Sabourin J,Manaud G,Bertero T,Rucker-Martin C,Riou M,Adão R,Manoury B,Lambert M,Boet A,Lecerf F,Domergue V,Brás-Silva C,Gomez AM,Montani D,Girerd B,Humbert M,Antigny F,Perros F

MiR-143-3p regulates early cartilage differentiation of BMSCs and promotes cartilage damage repair through targeting BMPR2.
European review for medical and pharmacological sciences22(24)8814-8821(2018 12)
Tian J,Rui YJ,Xu YJ,Zhang SA

Network of MicroRNAs Mediate Translational Repression of Bone Morphogenetic Protein Receptor-2: Involvement in HIV-Associated Pulmonary Vascular Remodeling.
Journal of the American Heart Association7(5)(2018 02)
Chinnappan M,Mohan A,Agarwal S,Dalvi P,Dhillon NK

Let-7a-transfected mesenchymal stem cells ameliorate monocrotaline-induced pulmonary hypertension by suppressing pulmonary artery smooth muscle cell growth through STAT3-BMPR2 signaling.
Stem cell research & therapy8(1)34(2017 02)
Cheng G,Wang X,Li Y,He L

Pulsed electromagnetic fields stimulate osteogenic differentiation and maturation of osteoblasts by upregulating the expression of BMPRII localized at the base of primary cilium.
Bone9322-32(2016 12)
Xie YF,Shi WG,Zhou J,Gao YH,Li SF,Fang QQ,Wang MG,Ma HP,Wang JF,Xian CJ,Chen KM