| Gene Symbol | Nudt1 |
| Entrez Gene ID | 117260 |
| Full Name | nudix hydrolase 1 |
| Synonyms | Mth1 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Rattus norvegicus(Norway rat) |
| Genome | |
| Summary | degrades 8-oxoguanine-containing deoxyribonucleoside triphosphate, a potentially mutagenic substrate for DNA synthesis; may control spontaneous mutagenesis [RGD, Feb 2006]. |
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Nudt1 cDNA ORF clone, Rattus norvegicus(Norway rat)
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Gene
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Clones
gRNAs
The following Nudt1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nudt1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID ORa11376 Clone ID Related Accession (Same CDS sequence) NM_057120.1 Accession Version NM_057120.1 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 471bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1577203200000 Organism Rattus norvegicus(Norway rat) Product 7,8-dihydro-8-oxoguanine triphosphatase precursor Comment Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from D49977.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D49977.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##
1
61
121
181
241
301
361
421ATGAGCACCT CCAGGCTTTA TACCCTCGTG CTGGTACTAC AGCCTCAGCG AGTTCTCCTG
GGCATGAAGA AGAGGGGCTT TGGTGCTGGC CGCTGGAATG GCTTCGGGGG CAAGGTGCAG
GAAGGAGAGA CCATTGAGGA TGGGGCTAAG AGGGAGCTTC TGGAAGAAAG TGGTCTGAGA
GTGGATACAC TGCACAAGGT AGGCCATATC TCATTTGAGT TTGTGGGCTC CCCCGAGCTG
ATGGACGTGC ATATCTTCTC TACCGACCAC GTGCATGGGA CACCCACAGA GAGTGAAGAA
ATGCGCCCTC AGTGGTTCCA ACTGGACCAG ATCCCCTTTG CCGACATGTG GCCGGACGAC
AGCTACTGGT TCCCACTCCT GCTTCAGAAG AAGAAGTTCT GTGGACACTT CAAGTTCCAT
GGTCAGGACA CCATCCTCAG TTACTCCCTG CGGGAGGTGG ATGAGTTCTA AThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_476461.1 CDS 15..485 Translation 
Target ORF information:
RefSeq Version NM_057120.1 Organism Rattus norvegicus(Norway rat) Definition Rattus norvegicus nudix hydrolase 1 (Nudt1), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_057120.1
ORF Insert Sequence:
1
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121
181
241
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361
421ATGAGCACCT CCAGGCTTTA TACCCTCGTG CTGGTACTAC AGCCTCAGCG AGTTCTCCTG
GGCATGAAGA AGAGGGGCTT TGGTGCTGGC CGCTGGAATG GCTTCGGGGG CAAGGTGCAG
GAAGGAGAGA CCATTGAGGA TGGGGCTAAG AGGGAGCTTC TGGAAGAAAG TGGTCTGAGA
GTGGATACAC TGCACAAGGT AGGCCATATC TCATTTGAGT TTGTGGGCTC CCCCGAGCTG
ATGGACGTGC ATATCTTCTC TACCGACCAC GTGCATGGGA CACCCACAGA GAGTGAAGAA
ATGCGCCCTC AGTGGTTCCA ACTGGACCAG ATCCCCTTTG CCGACATGTG GCCGGACGAC
AGCTACTGGT TCCCACTCCT GCTTCAGAAG AAGAAGTTCT GTGGACACTT CAAGTTCCAT
GGTCAGGACA CCATCCTCAG TTACTCCCTG CGGGAGGTGG ATGAGTTCTA AThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID ORa34636 Clone ID Related Accession (Same CDS sequence) XM_006248911.3 Accession Version XM_006248911.3 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 471bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1469376000000 Organism Rattus norvegicus(Norway rat) Product 7,8-dihydro-8-oxoguanine triphosphatase isoform X1 Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005111.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006248911.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##
1
61
121
181
241
301
361
421ATGAGCACCT CCAGGCTTTA TACCCTCGTG CTGGTACTAC AGCCTCAGCG AGTTCTCCTG
GGCATGAAGA AGAGGGGCTT TGGTGCTGGC CGCTGGAATG GCTTCGGGGG CAAGGTGCAG
GAAGGAGAGA CCATTGAGGA TGGGGCTAAG AGGGAGCTTC TGGAAGAAAG TGGTCTGAGA
GTGGATACAC TGCACAAGGT AGGCCATATC TCATTTGAGT TTGTGGGCTC CCCCGAGCTG
ATGGACGTGC ATATCTTCTC TACCGACCAC GTGCATGGGA CGCCCACAGA GAGTGAAGAA
ATGCGCCCTC AGTGGTTCCA ACTGGACCAG ATCCCCTTTG CCGACATGTG GCCGGACGAC
AGCTACTGGT TCCCACTCCT GCTTCAGAAG AAGAAGTTCT GTGGACACTT CAAGTTCCAT
GGTCAGGACA CCATCCTCAG TTACTCCCTG CGGGAGGTGG ATGAGTTCTA AThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq XP_006248973.1 CDS 91..561 Translation
Target ORF information:
RefSeq Version XM_006248911.3 Organism Rattus norvegicus(Norway rat) Definition Rattus norvegicus nudix hydrolase 1 (Nudt1), transcript variant X1, mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK XM_006248911.3
ORF Insert Sequence:
1
61
121
181
241
301
361
421ATGAGCACCT CCAGGCTTTA TACCCTCGTG CTGGTACTAC AGCCTCAGCG AGTTCTCCTG
GGCATGAAGA AGAGGGGCTT TGGTGCTGGC CGCTGGAATG GCTTCGGGGG CAAGGTGCAG
GAAGGAGAGA CCATTGAGGA TGGGGCTAAG AGGGAGCTTC TGGAAGAAAG TGGTCTGAGA
GTGGATACAC TGCACAAGGT AGGCCATATC TCATTTGAGT TTGTGGGCTC CCCCGAGCTG
ATGGACGTGC ATATCTTCTC TACCGACCAC GTGCATGGGA CGCCCACAGA GAGTGAAGAA
ATGCGCCCTC AGTGGTTCCA ACTGGACCAG ATCCCCTTTG CCGACATGTG GCCGGACGAC
AGCTACTGGT TCCCACTCCT GCTTCAGAAG AAGAAGTTCT GTGGACACTT CAAGTTCCAT
GGTCAGGACA CCATCCTCAG TTACTCCCTG CGGGAGGTGG ATGAGTTCTA AThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
Chenodeoxycholic Acid Derivative HS-1200 Inhibits Hepatocarcinogenesis and Improves Liver Function in Diethylnitrosamine-Exposed Rats by Downregulating MTH1.
BioMed research international20171465912(2017)
Xu M,Zhao Q,Shao D,Liu H,Qi J,Qin C
Human MTH3 (NUDT18) protein hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates: comparison with MTH1 and MTH2.
The Journal of biological chemistry287(25)21541-9(2012 Jun)
Takagi Y,Setoyama D,Ito R,Kamiya H,Yamagata Y,Sekiguchi M
Oxidative damage to RNA and expression patterns of MTH1 in the hippocampi of senescence-accelerated SAMP8 mice and Alzheimer's disease patients.
Neurochemical research36(8)1558-65(2011 Aug)
Song XN,Zhang LQ,Liu DG,Lin J,Zheng JD,Dai DP,Hei AL,Hayakawa H,Sekiguchi M,Cai JP
Multiple mRNA decapping enzymes in mammalian cells.
Molecular cell40(3)423-32(2010 Nov)
Song MG,Li Y,Kiledjian M
Accumulation of 8-oxo-deoxyguanosine in cardiovascular tissues with the development of hypertension.
DNA repair6(6)760-9(2007 Jun)
Ohtsubo T,Ohya Y,Nakamura Y,Kansui Y,Furuichi M,Matsumura K,Fujii K,Iida M,Nakabeppu Y
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