Nppc cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Nppc
Entrez Gene ID	114593
Full Name	natriuretic peptide C
General protein information	Preferred Names natriuretic peptide C Names C-type natriuretic peptide natriuretic peptide precursor C natriuretic peptide precursor type C
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 9 Map Location: 9q35
Summary	binds natriuretic peptide receptor; involved in inhibition of growth and proliferation in vascular smooth muscle cells [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053750.1	NP_446202.1	C-type natriuretic peptide precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	NPPC	XP_852684.1
Rattus norvegicus (Norway rat)	Nppc	NP_446202.1
Pan troglodytes (chimpanzee)	NPPC	XP_001141992.1
Xenopus tropicalis (tropical clawed frog)	nppc	NP_001106395.1
Macaca mulatta (Rhesus monkey)	NPPC	XP_001108190.2
Homo sapiens (human)	NPPC	NP_077720.1
Bos taurus (cattle)	NPPC	NP_776550.1
Danio rerio (zebrafish)	LOC100536373	XP_003201196.1
Mus musculus (house mouse)	Nppc	NP_035063.1
Danio rerio (zebrafish)	si:ch211-126j24.3	NP_001103410.1

Gene Ontology
Bibliography

Related articles in PubMed

Exogenous C-type natriuretic peptide restores normal growth and prevents early growth plate closure in its deficient rats.
Hirota K, Furuya M, Morozumi N, Yoshikiyo K, Yotsumoto T, Jindo T, Nakamura R, Murakami K, Ueda Y, Hanada T, Sade H, Yoshida S, Enomoto K, Kanai Y, Yamauchi I, Yamashita T, Ueda-Sakane Y, Fujii T, Yasoda A, Inagaki N
PloS one13(9)e0204172(2018)

Rats deficient C-type natriuretic peptide suffer from impaired skeletal growth without early death.
Fujii T, Hirota K, Yasoda A, Takizawa A, Morozumi N, Nakamura R, Yotsumoto T, Kondo E, Yamashita Y, Sakane Y, Kanai Y, Ueda Y, Yamauchi I, Yamanaka S, Nakao K, Kuwahara K, Jindo T, Furuya M, Mashimo T, Inagaki N, Serikawa T, Nakao K
PloS one13(3)e0194812(2018)

Elevated C-type natriuretic peptide elicits exercise preconditioning-induced cardioprotection against myocardial injury probably via the up-regulation of NPR-B.
Lu J, Pan SS
The journal of physiological sciences : JPS67(4)475-487(2017 Jul)

C-type natriuretic peptide and natriuretic peptide receptor B signalling inhibits cardiac sympathetic neurotransmission and autonomic function.
Buttgereit J, Shanks J, Li D, Hao G, Athwal A, Langenickel TH, Wright H, da Costa Goncalves AC, Monti J, Plehm R, Popova E, Qadri F, Lapidus I, Ryan B, Özcelik C, Paterson DJ, Bader M, Herring N
Cardiovascular research112(3)637-644(2016 12)

Catalytically Active Guanylyl Cyclase B Requires Endoplasmic Reticulum-mediated Glycosylation, and Mutations That Inhibit This Process Cause Dwarfism.
Dickey DM, Edmund AB, Otto NM, Chaffee TS, Robinson JW, Potter LR
The Journal of biological chemistry291(21)11385-93(2016 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Nppc gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nppc cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa10512	NM_053750.1 Latest version!	Rattus norvegicus natriuretic peptide C (Nppc), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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2-4 Clone	40% OFF
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Nppc ( NM_053750.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_446202.1 Rattus norvegicus natriuretic peptide C (Nppc), mRNA.

Price & Availability↑

CloneID	ORa10512
Clone ID Related Accession (Same CDS sequence)	NM_053750.1
Accession Version	NM_053750.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 381bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577289600000
Organism	Rattus norvegicus(Norway rat)
Product	C-type natriuretic peptide precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from D90219.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D90219.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGCACCTCT CCCAGCTGAT CGCCTGTGCC CTGCTGCTCG CGCTACTCTC ACTCCGGCCC 
TCCGAAGCCA AGCCCGGGAC ACCACCGAAG GTCCCGAGAA CCCCGCCAGG GGAGGAGCTG 
GCAGAGCCCC AGGCAGCTGG TGGCAATCAG AAAAAGGGTG ACAAGACTCC AGGCGGCGGG 
GGAGCCAATC TCAAGGGAGA CCGATCGCGA CTGCTTCGGG ACCTGCGTGT GGACACCAAG 
TCCCGGGCGG CGTGGGCTCG CCTTCTGCAC GAGCACCCCA ACGCGCGCAA ATACAAAGGC 
GGCAACAAGA AGGGCTTGTC CAAAGGCTGC TTTGGCCTCA AGCTGGACCG GATCGGCTCC 
ATGAGCGGTC TGGGATGTTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_446202.1
CDS	117..497
Translation	MHLSQLIACALLLALLSLRPSEAKPGTPPKVPRTPPGEELAEPQAAGGNQKKGDKTPGGGGANLKGDRSRLLRDLRVDTKSRAAWARLLHEHPNARKYKGGNKKGLSKGCFGLKLDRIGSMSGLGC

Target ORF information:

RefSeq Version	NM_053750.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus natriuretic peptide C (Nppc), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053750.1

ORF Insert Sequence:

ATGCACCTCT CCCAGCTGAT CGCCTGTGCC CTGCTGCTCG CGCTACTCTC ACTCCGGCCC 
TCCGAAGCCA AGCCCGGGAC ACCACCGAAG GTCCCGAGAA CCCCGCCAGG GGAGGAGCTG 
GCAGAGCCCC AGGCAGCTGG TGGCAATCAG AAAAAGGGTG ACAAGACTCC AGGCGGCGGG 
GGAGCCAATC TCAAGGGAGA CCGATCGCGA CTGCTTCGGG ACCTGCGTGT GGACACCAAG 
TCCCGGGCGG CGTGGGCTCG CCTTCTGCAC GAGCACCCCA ACGCGCGCAA ATACAAAGGC 
GGCAACAAGA AGGGCTTGTC CAAAGGCTGC TTTGGCCTCA AGCTGGACCG GATCGGCTCC 
ATGAGCGGTC TGGGATGTTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Exogenous C-type natriuretic peptide restores normal growth and prevents early growth plate closure in its deficient rats.
PloS one13(9)e0204172(2018)
Hirota K,Furuya M,Morozumi N,Yoshikiyo K,Yotsumoto T,Jindo T,Nakamura R,Murakami K,Ueda Y,Hanada T,Sade H,Yoshida S,Enomoto K,Kanai Y,Yamauchi I,Yamashita T,Ueda-Sakane Y,Fujii T,Yasoda A,Inagaki N

Rats deficient C-type natriuretic peptide suffer from impaired skeletal growth without early death.
PloS one13(3)e0194812(2018)
Fujii T,Hirota K,Yasoda A,Takizawa A,Morozumi N,Nakamura R,Yotsumoto T,Kondo E,Yamashita Y,Sakane Y,Kanai Y,Ueda Y,Yamauchi I,Yamanaka S,Nakao K,Kuwahara K,Jindo T,Furuya M,Mashimo T,Inagaki N,Serikawa T,Nakao K

Elevated C-type natriuretic peptide elicits exercise preconditioning-induced cardioprotection against myocardial injury probably via the up-regulation of NPR-B.
The journal of physiological sciences : JPS67(4)475-487(2017 Jul)
Lu J,Pan SS

C-type natriuretic peptide and natriuretic peptide receptor B signalling inhibits cardiac sympathetic neurotransmission and autonomic function.
Cardiovascular research112(3)637-644(2016 12)
Buttgereit J,Shanks J,Li D,Hao G,Athwal A,Langenickel TH,Wright H,da Costa Goncalves AC,Monti J,Plehm R,Popova E,Qadri F,Lapidus I,Ryan B,Özcelik C,Paterson DJ,Bader M,Herring N

Catalytically Active Guanylyl Cyclase B Requires Endoplasmic Reticulum-mediated Glycosylation, and Mutations That Inhibit This Process Cause Dwarfism.
The Journal of biological chemistry291(21)11385-93(2016 May)
Dickey DM,Edmund AB,Otto NM,Chaffee TS,Robinson JW,Potter LR

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Nppc cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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