PCSK9 cDNA ORF clone, Pan troglodytes(chimpanzee)

Gene
Clones
gRNAs

Summary

Gene Symbol	PCSK9
Entrez Gene ID	456880
Full Name	proprotein convertase subtilisin/kexin type 9
Synonyms	PC9
General protein information	Preferred Names proprotein convertase subtilisin/kexin type 9 Names proprotein convertase subtilisin/kexin type 9 convertase subtilisin/kexin type 9 preproprotein proprotein convertase 9 proprotein convertase PC9 subtilisin/kexin-like protease PC9
Gene Type	protein-coding
Organism	Pan troglodytes(chimpanzee)

mRNA and Protein(s)

mRNA	Protein	Name
XM_024347585.1	XP_024203353.1	proprotein convertase subtilisin/kexin type 9 isoform X1
XM_016953243.1	XP_016808732.1	proprotein convertase subtilisin/kexin type 9 isoform X1
NM_001111122.1	NP_001104592.1	proprotein convertase subtilisin/kexin type 9 precursor
XM_016953243.2	XP_016808732.2	proprotein convertase subtilisin/kexin type 9 isoform X2

Pathways from BioSystems

Homologies

Saccharomyces cerevisiae (baker's yeast)	YSP3	NP_014645.1
Xenopus tropicalis (tropical clawed frog)	pcsk9	XP_002931479.1
Homo sapiens (human)	PCSK9	NP_777596.2
Danio rerio (zebrafish)	pcsk9	XP_003200725.1
Schizosaccharomyces pombe (fission yeast)	psp3	NP_594848.1
Pan troglodytes (chimpanzee)	PCSK9	NP_001104592.1
Macaca mulatta (Rhesus monkey)	PCSK9	NP_001106130.1
Mus musculus (house mouse)	Pcsk9	NP_705793.1
Rattus norvegicus (Norway rat)	Pcsk9	NP_954862.2
Gallus gallus (chicken)	PCSK9	XP_003641739.2

Gene Ontology
Bibliography

Related articles in PubMed

Ossabaw Pigs With a PCSK9 Gain-of-Function Mutation Develop Accelerated Coronary Atherosclerotic Lesions: A Novel Model for Preclinical Studies.
Yuan F, Guo L, Park KH, Woollard JR, Taek-Geun K, Jiang K, Melkamu T, Zang B, Smith SL, Fahrenkrug SC, Kolodgie FD, Lerman A, Virmani R, Lerman LO, Carlson DF
Journal of the American Heart Association7(6)(2018 03)

Evidence for positive selection in the C-terminal domain of the cholesterol metabolism gene PCSK9 based on phylogenetic analysis in 14 primate species.
Ding K, McDonough SJ, Kullo IJ
PloS one2(10)e1098(2007 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following PCSK9 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PCSK9 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OPc00225	NM_001111122.1 Latest version!	Pan troglodytes proprotein convertase subtilisin/kexin type 9 (PCSK9), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00
OPc58091	XM_016953243.1 Latest version!	Pan troglodytes proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00
OPc91983	XM_024347585.1 Latest version!	Pan troglodytes proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00
OPc91984	XM_016953243.2 Latest version!	Pan troglodytes proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PCSK9 ( NM_001111122.1 ) cDNA ORF clone, Pan troglodytes(chimpanzee) -> NP_001104592.1 Pan troglodytes proprotein convertase subtilisin/kexin type 9 (PCSK9), mRNA.

Price & Availability↑

CloneID	OPc00225
Clone ID Related Accession (Same CDS sequence)	NM_001111122.1
Accession Version	NM_001111122.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2079bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577116800000
Organism	Pan troglodytes(chimpanzee)
Product	proprotein convertase subtilisin/kexin type 9 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from EF692497.1. On or before Dec 9, 2007 this sequence version replaced XM_513430.2, XM_001154126.1. ##Evidence-Data-START## Transcript exon combination :: EF692497.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01120800, SAMN01120804 [ECO:0000348] ##Evidence-Data-END##

ATGGGCACCG TCAGCTCCAG GCGGTCCTGG TGGCCGCTGC CACTGCTGCT GCTGCTGCTG 
CTGCTCCTGG GTCCCGCGGG CGCCCGTGCG CAGGAGGACG AGGACGGCGA CTACGAGGAG 
CTGGTGCTAG CCTTGCGTTC CGAGGAGGAC GGCCTGGCCG AAGCACCCGA GCACGGAACC 
ACAGCCACCT TCCACCGCTG CGCCAAGGAT CCGTGGAGGT TGCCTGGCAC CTACGTGGTG 
GTGCTGAAGG AGGAGACCCA CCTCTCGCAG TCAGAGCGCA CTGCCCGCCG CCTGCAGGCC 
CAAGCTGCCC GCCGAGGATA CCTCACCAAG ATCCTGCATG TCTTCCATGG CCTTCTTCCT 
GGCTTCCTGG TGAAGATGAG TGGTGACCTG CTGGAGCTGG CCTTGAAGTT GCCCCATGTC 
GACTACATCG AGGAGGACTC CTCTGTCTTT GCCCAGAGCA TCCCGTGGAA CCTGGAGCGG 
ATTACCCCTC CACGGTACCG GGCGGATGAA TACCAGCCCC CCGATGGAGG CAGCCTGGTG 
GAGGTGTATC TCCTAGACAC CAGCATACAG AGTGACCACC GGGAAATCGA GGGCAGGGTC 
ATGGTCACCG ACTTCGAGAA TGTGCCCGAG GAGGACGGGA CCCGCTTCCA CAGACAGGCC 
AGCAAGTGTG ACAGTCATGG CACCCACCTG GCAGGGGTGG TCAGCGGCCG GGATGCCGGC 
GTGGCCAAGG GTGCCAGCAT GCGCAGCCTG CGCGTGCTCA ACTGCCAAGG GAAGGGCACG 
GTTAGCGGCA CCCTCATAGG CCTGGAGTTT ATTCGGAAAA GCCAGCTGGT CCAGCCTGTG 
GGGCCACTGG TGGTGCTGCT GCCCCTGGCG GGTGGGTACA GCCGCGTCCT CAACGCCGCC 
TGCCAGCGCC TGGCGAGGGC TGGGGTTGTG CTGGTCACCG CTGCCGGCAA CTTCCGGGAC 
GATGCCTGCC TCTACTCCCC AGCCTCAGCT CCCGAGGTTA TCACAGTTGG GGCCACCAAT 
GCCCAGGACC AGCCGGTGAC CCTGGGGACT TTGGGGACCA ACTTTGGCCG CTGTGTGGAC 
CTCTTTGCCC CAGGGGAGGA CATCATTGGT GCCTCCAGCG ACTGCAGCAC CTGCTTTGTG 
TCACAGAGTG GGACATCACA GGCTGCTGCC CACGTGGCTG GCATTGCAGC CATGATGCTG 
TCTGCCGAGC CGGAGCTCAC CCTGGCCGAG TTGAGGCAGA GACTGATCCA CTTCTCTGCC 
AAAGATGTCA TCAATGAGGC CTGGTTCCCT GAGGACCAGC GGGTACTGAC CCCTAACCTG 
GTGGCCGCCC TGCCCCCCAG CACCCATGGG GCAGGTTGGC AGCTGTTTTG CAGGACTGTG 
TGGTCAGCAC ACTCGGGGCC TACACGGATG GCCACAGCCG TCGCCCGCTG CGCCCCAGAT 
GAGGAGCTGC TGAGCTGCTC CAGTTTCTCC AGGAGTGGGA AGCGGCGGGG CGAGCGCATG 
GAGGCCCAAG GGGGCAAGCT GGTCTGCCGG GCCCACAACG CTTTTGGGGG TGAGGGTGTC 
TACGCCATTG CCAGGTGCTG CCTGCTACCC CAGGCCAACT GCAGCATCCA CACAGCTCCA 
CCAGCTGAGG CCGGCATGGG GACCCGTGTC CACTGCCACC AACAGGGCCA CGTCCTCACA 
GGCTGCAGCT CCCACTGGGA GGTGGAGGAC CTTGGCACCC ACAAGCCGCC TATGCTGAGG 
CCACGAGGTC AGCCCAACCA GTGCGTGGGC CACAGGGAGG CCAGCATCCA CGCTTCCTGC 
TGCCGTGCCC CAGGTCTGGA ATGCAAAGTC AAGGAGCATG GAATCCCGGC CCCTCAGGAG 
CAGGTGACCG TGGCCTGCGA GGAGGGCTGG ACCCTGACTG GCTGCAGTGC CCTCCCTGGG 
ACCTCCCACG TCCTGGGGGC CTACGCCGTA GACAACACGT GTGTAGTCAG GAGCCGGGAC 
GTCAGCACTG CAGGCAGCAC CAGTGAAGAG GCCGTGGCAG CCGTTGCCAT CTGCTGCCGG 
AGCCGGCACC TGGCACAGGC CTCCCAGGAG CTCCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001104592.1
CDS	1..2079
Translation	MGTVSSRRSWWPLPLLLLLLLLLGPAGARAQEDEDGDYEELVLALRSEEDGLAEAPEHGTTATFHRCAKDPWRLPGTYVVVLKEETHLSQSERTARRLQAQAARRGYLTKILHVFHGLLPGFLVKMSGDLLELALKLPHVDYIEEDSSVFAQSIPWNLERITPPRYRADEYQPPDGGSLVEVYLLDTSIQSDHREIEGRVMVTDFENVPEEDGTRFHRQASKCDSHGTHLAGVVSGRDAGVAKGASMRSLRVLNCQGKGTVSGTLIGLEFIRKSQLVQPVGPLVVLLPLAGGYSRVLNAACQRLARAGVVLVTAAGNFRDDACLYSPASAPEVITVGATNAQDQPVTLGTLGTNFGRCVDLFAPGEDIIGASSDCSTCFVSQSGTSQAAAHVAGIAAMMLSAEPELTLAELRQRLIHFSAKDVINEAWFPEDQRVLTPNLVAALPPSTHGAGWQLFCRTVWSAHSGPTRMATAVARCAPDEELLSCSSFSRSGKRRGERMEAQGGKLVCRAHNAFGGEGVYAIARCCLLPQANCSIHTAPPAEAGMGTRVHCHQQGHVLTGCSSHWEVEDLGTHKPPMLRPRGQPNQCVGHREASIHASCCRAPGLECKVKEHGIPAPQEQVTVACEEGWTLTGCSALPGTSHVLGAYAVDNTCVVRSRDVSTAGSTSEEAVAAVAICCRSRHLAQASQELQ

Target ORF information:

RefSeq Version	NM_001111122.1
Organism	Pan troglodytes(chimpanzee)
Definition	Pan troglodytes proprotein convertase subtilisin/kexin type 9 (PCSK9), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001111122.1

ORF Insert Sequence:

ATGGGCACCG TCAGCTCCAG GCGGTCCTGG TGGCCGCTGC CACTGCTGCT GCTGCTGCTG 
CTGCTCCTGG GTCCCGCGGG CGCCCGTGCG CAGGAGGACG AGGACGGCGA CTACGAGGAG 
CTGGTGCTAG CCTTGCGTTC CGAGGAGGAC GGCCTGGCCG AAGCACCCGA GCACGGAACC 
ACAGCCACCT TCCACCGCTG CGCCAAGGAT CCGTGGAGGT TGCCTGGCAC CTACGTGGTG 
GTGCTGAAGG AGGAGACCCA CCTCTCGCAG TCAGAGCGCA CTGCCCGCCG CCTGCAGGCC 
CAAGCTGCCC GCCGAGGATA CCTCACCAAG ATCCTGCATG TCTTCCATGG CCTTCTTCCT 
GGCTTCCTGG TGAAGATGAG TGGTGACCTG CTGGAGCTGG CCTTGAAGTT GCCCCATGTC 
GACTACATCG AGGAGGACTC CTCTGTCTTT GCCCAGAGCA TCCCGTGGAA CCTGGAGCGG 
ATTACCCCTC CACGGTACCG GGCGGATGAA TACCAGCCCC CCGATGGAGG CAGCCTGGTG 
GAGGTGTATC TCCTAGACAC CAGCATACAG AGTGACCACC GGGAAATCGA GGGCAGGGTC 
ATGGTCACCG ACTTCGAGAA TGTGCCCGAG GAGGACGGGA CCCGCTTCCA CAGACAGGCC 
AGCAAGTGTG ACAGTCATGG CACCCACCTG GCAGGGGTGG TCAGCGGCCG GGATGCCGGC 
GTGGCCAAGG GTGCCAGCAT GCGCAGCCTG CGCGTGCTCA ACTGCCAAGG GAAGGGCACG 
GTTAGCGGCA CCCTCATAGG CCTGGAGTTT ATTCGGAAAA GCCAGCTGGT CCAGCCTGTG 
GGGCCACTGG TGGTGCTGCT GCCCCTGGCG GGTGGGTACA GCCGCGTCCT CAACGCCGCC 
TGCCAGCGCC TGGCGAGGGC TGGGGTTGTG CTGGTCACCG CTGCCGGCAA CTTCCGGGAC 
GATGCCTGCC TCTACTCCCC AGCCTCAGCT CCCGAGGTTA TCACAGTTGG GGCCACCAAT 
GCCCAGGACC AGCCGGTGAC CCTGGGGACT TTGGGGACCA ACTTTGGCCG CTGTGTGGAC 
CTCTTTGCCC CAGGGGAGGA CATCATTGGT GCCTCCAGCG ACTGCAGCAC CTGCTTTGTG 
TCACAGAGTG GGACATCACA GGCTGCTGCC CACGTGGCTG GCATTGCAGC CATGATGCTG 
TCTGCCGAGC CGGAGCTCAC CCTGGCCGAG TTGAGGCAGA GACTGATCCA CTTCTCTGCC 
AAAGATGTCA TCAATGAGGC CTGGTTCCCT GAGGACCAGC GGGTACTGAC CCCTAACCTG 
GTGGCCGCCC TGCCCCCCAG CACCCATGGG GCAGGTTGGC AGCTGTTTTG CAGGACTGTG 
TGGTCAGCAC ACTCGGGGCC TACACGGATG GCCACAGCCG TCGCCCGCTG CGCCCCAGAT 
GAGGAGCTGC TGAGCTGCTC CAGTTTCTCC AGGAGTGGGA AGCGGCGGGG CGAGCGCATG 
GAGGCCCAAG GGGGCAAGCT GGTCTGCCGG GCCCACAACG CTTTTGGGGG TGAGGGTGTC 
TACGCCATTG CCAGGTGCTG CCTGCTACCC CAGGCCAACT GCAGCATCCA CACAGCTCCA 
CCAGCTGAGG CCGGCATGGG GACCCGTGTC CACTGCCACC AACAGGGCCA CGTCCTCACA 
GGCTGCAGCT CCCACTGGGA GGTGGAGGAC CTTGGCACCC ACAAGCCGCC TATGCTGAGG 
CCACGAGGTC AGCCCAACCA GTGCGTGGGC CACAGGGAGG CCAGCATCCA CGCTTCCTGC 
TGCCGTGCCC CAGGTCTGGA ATGCAAAGTC AAGGAGCATG GAATCCCGGC CCCTCAGGAG 
CAGGTGACCG TGGCCTGCGA GGAGGGCTGG ACCCTGACTG GCTGCAGTGC CCTCCCTGGG 
ACCTCCCACG TCCTGGGGGC CTACGCCGTA GACAACACGT GTGTAGTCAG GAGCCGGGAC 
GTCAGCACTG CAGGCAGCAC CAGTGAAGAG GCCGTGGCAG CCGTTGCCAT CTGCTGCCGG 
AGCCGGCACC TGGCACAGGC CTCCCAGGAG CTCCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PCSK9 ( XM_016953243.1 ) cDNA ORF clone, Pan troglodytes(chimpanzee) -> XP_016808732.1 Pan troglodytes proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OPc58091
Clone ID Related Accession (Same CDS sequence)	XM_016953243.1
Accession Version	XM_016953243.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2133bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1464710400000
Organism	Pan troglodytes(chimpanzee)
Product	proprotein convertase subtilisin/kexin type 9 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_006468.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Pan troglodytes Annotation Release 104 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGGCTCT GGTGGCGTGA TCTGCGCGCC CCAGGCGTCA AGCACCCACA CCCTAGAAGG 
TTTCCGCAGC GACGTCGAGG CGCTCGTGGT TGCAGGCGGG CGCCGCCGTT CAGTTCAGGG 
TCCGAGCCTG GAGGAGTGAG CCAGGCAGTG AGACTGGCTC GGGCGGGCCG GGACGCGTCG 
TTGCAGCAGC GGCTCCCAGC TCCCAGCCAG GATTCCGCGC GCCCCTTCAC GCGCCCTGCT 
CCTGAACTTC AGCTCCTGCA CAGTCCTCCC CACCGCAAGG CTCAAGGCGC CGCCGGCGTG 
GACCGCACAC GGCCTCTAGG TCTCCTCGCC AGGACAGCAA CCTCTCCCCT GGCCCTCATG 
GGCACCGTCA GCTCCAGGCG GTCCTGGTGG CCGCTGCCAC TGCTGCTGCT GCTGCTGCTG 
CTGCTGCTCC TGGGTCCCGC GGGCGCCCGT GCGCAGGAGG ACGAGGACGG CGACTACGAG 
GAGCTGGTGC TAGCCTTGCG TTCCGAGGAG GACGGCCTGG CCGAAGCACC CGAGCACGGA 
ACCACAGCCA CCTTCCACCG CTGCGCCAAG GATCCGTGGA GGTTGCCTGG CACCTACGTG 
GTGGTGCTGA AGGAGGAGAC CCACCTCTCG CAGTCAGAGC GCACTGCCCG CCGCCTGCAG 
GCCCAAGCTG CCCGCCGAGG ATACCTCACC AAGATCCTGC ATGTCTTCCA TGGCCTTCTT 
CCTGGCTTCC TGGTGAAGAT GAGTGGTGAC CTGCTGGAGC TGGCCTTGAA GTTGCCCCAT 
GTCGACTACA TCGAGGAGGA CTCCTCTGTC TTTGCCCAGA GCATCCCGTG GAACCTGGAG 
CGGATTACCC CTCCACGGTA CCGGGCGGAT GAATACCAGC CCCCCGATGG AGGCAGCCTG 
GTGGAGGTGT ATCTCCTAGA CACCAGCATA CAGAGTGACC ACCGGGAAAT CGAGGGCAGG 
GTCATGGTCA CCGACTTCGA GAATGTGCCC GAGGAGGACG GGACCCGCTT CCACAGACAG 
GCCAGCAAGT GTGACAGTCA TGGCACCCAC CTGGCAGGGG TGGTCAGCGG CCGGGATGCC 
GGCGTGGCCA AGGGTGCCAG CATGCGCAGC CTGCGCGTGC TCAACTGCCA AGGGAAGGGC 
ACGGTTAGCG GCACCCTCAT AGGCCTGGAG TTTATTCGGA AAAGCCAGCT GGTCCAGCCT 
GTGGGGCCAC TGGTGGTGCT GCTGCCCCTG GCGGGTGGGT ACAGCCGCGT CCTCAACGCC 
GCCTGCCAGC GCCTGGCGAG GGCTGGGGTT GTGCTGGTCA CCGCTGCCGG CAACTTCCGG 
GACGATGCCT GCCTCTACTC CCCAGCCTCA GCTCCCGAGG TCATCACAGT TGGGGCCACC 
AATGCCCAGG ACCAGCCGGT GACCCTGGGG ACTTTGGGGA CCAACTTTGG CCGCTGTGTG 
GACCTCTTTG CCCCAGGGGA GGACATCATT GGTGCCTCCA GCGACTGCAG CACCTGCTTT 
GTGTCACAGA GTGGGACATC ACAGGCTGCT GCCCACGTGG CTGGCATTGC AGCCATGATG 
CTGTCTGCCG AGCCGGAGCT CACCCTGGCC GAGTTGAGGC AGAGACTGAT CCACTTCTCT 
GCCAAAGATG TCATCAATGA GGCCTGGTTC CCTGAGGACC AGCGGGTACT GACCCCTAAC 
CTGGTGGCCG CCCTGCCCCC CAGCACCCAT GGGGCAGGTT GGCAGCTGTT TTGCAGGACT 
GTGTGGTCAG CACACTCGGG GCCTACACGG ATGGCCACAG CCGTCGCCCG CTGCGCCCCA 
GATGAGGAGC TGCTGAGCTG CTCCAGTTTC TCCAGGAGTG GGAAGCGGCG GGGCGAGCGC 
ATGGAGGCCC AAGGGGGCAA GCTGGTCTGC CGGGCCCACA ACGCTTTTGG GGGTGAGGGT 
GTCTACGCCA TTGCCAGGTG CTGCCTGCTA CCCCAGGCCA ACTGCAGCAT CCACACAGCT 
CCACCAGCTG AGGCCGGCAT GGGGACCCGT GTCCACTGCC ACCAACAGGG CCACGTCCTC 
ACAGGTTTCC TAGCTCTTGC CTCAGACCTT AAAGAGAGAG GGTCTGATGG GGATGGGCAC 
TGGAGACGGA GCATCCCAGC ATTTCACATC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016808732.1
CDS	137..2269
Translation	MGLWWRDLRAPGVKHPHPRRFPQRRRGARGCRRAPPFSSGSEPGGVSQAVRLARAGRDASLQQRLPAPSQDSARPFTRPAPELQLLHSPPHRKAQGAAGVDRTRPLGLLARTATSPLALMGTVSSRRSWWPLPLLLLLLLLLLLGPAGARAQEDEDGDYEELVLALRSEEDGLAEAPEHGTTATFHRCAKDPWRLPGTYVVVLKEETHLSQSERTARRLQAQAARRGYLTKILHVFHGLLPGFLVKMSGDLLELALKLPHVDYIEEDSSVFAQSIPWNLERITPPRYRADEYQPPDGGSLVEVYLLDTSIQSDHREIEGRVMVTDFENVPEEDGTRFHRQASKCDSHGTHLAGVVSGRDAGVAKGASMRSLRVLNCQGKGTVSGTLIGLEFIRKSQLVQPVGPLVVLLPLAGGYSRVLNAACQRLARAGVVLVTAAGNFRDDACLYSPASAPEVITVGATNAQDQPVTLGTLGTNFGRCVDLFAPGEDIIGASSDCSTCFVSQSGTSQAAAHVAGIAAMMLSAEPELTLAELRQRLIHFSAKDVINEAWFPEDQRVLTPNLVAALPPSTHGAGWQLFCRTVWSAHSGPTRMATAVARCAPDEELLSCSSFSRSGKRRGERMEAQGGKLVCRAHNAFGGEGVYAIARCCLLPQANCSIHTAPPAEAGMGTRVHCHQQGHVLTGFLALASDLKERGSDGDGHWRRSIPAFHI

Target ORF information:

RefSeq Version	XM_016953243.1
Organism	Pan troglodytes(chimpanzee)
Definition	Pan troglodytes proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_016953243.1

ORF Insert Sequence:

ATGGGGCTCT GGTGGCGTGA TCTGCGCGCC CCAGGCGTCA AGCACCCACA CCCTAGAAGG 
TTTCCGCAGC GACGTCGAGG CGCTCGTGGT TGCAGGCGGG CGCCGCCGTT CAGTTCAGGG 
TCCGAGCCTG GAGGAGTGAG CCAGGCAGTG AGACTGGCTC GGGCGGGCCG GGACGCGTCG 
TTGCAGCAGC GGCTCCCAGC TCCCAGCCAG GATTCCGCGC GCCCCTTCAC GCGCCCTGCT 
CCTGAACTTC AGCTCCTGCA CAGTCCTCCC CACCGCAAGG CTCAAGGCGC CGCCGGCGTG 
GACCGCACAC GGCCTCTAGG TCTCCTCGCC AGGACAGCAA CCTCTCCCCT GGCCCTCATG 
GGCACCGTCA GCTCCAGGCG GTCCTGGTGG CCGCTGCCAC TGCTGCTGCT GCTGCTGCTG 
CTGCTGCTCC TGGGTCCCGC GGGCGCCCGT GCGCAGGAGG ACGAGGACGG CGACTACGAG 
GAGCTGGTGC TAGCCTTGCG TTCCGAGGAG GACGGCCTGG CCGAAGCACC CGAGCACGGA 
ACCACAGCCA CCTTCCACCG CTGCGCCAAG GATCCGTGGA GGTTGCCTGG CACCTACGTG 
GTGGTGCTGA AGGAGGAGAC CCACCTCTCG CAGTCAGAGC GCACTGCCCG CCGCCTGCAG 
GCCCAAGCTG CCCGCCGAGG ATACCTCACC AAGATCCTGC ATGTCTTCCA TGGCCTTCTT 
CCTGGCTTCC TGGTGAAGAT GAGTGGTGAC CTGCTGGAGC TGGCCTTGAA GTTGCCCCAT 
GTCGACTACA TCGAGGAGGA CTCCTCTGTC TTTGCCCAGA GCATCCCGTG GAACCTGGAG 
CGGATTACCC CTCCACGGTA CCGGGCGGAT GAATACCAGC CCCCCGATGG AGGCAGCCTG 
GTGGAGGTGT ATCTCCTAGA CACCAGCATA CAGAGTGACC ACCGGGAAAT CGAGGGCAGG 
GTCATGGTCA CCGACTTCGA GAATGTGCCC GAGGAGGACG GGACCCGCTT CCACAGACAG 
GCCAGCAAGT GTGACAGTCA TGGCACCCAC CTGGCAGGGG TGGTCAGCGG CCGGGATGCC 
GGCGTGGCCA AGGGTGCCAG CATGCGCAGC CTGCGCGTGC TCAACTGCCA AGGGAAGGGC 
ACGGTTAGCG GCACCCTCAT AGGCCTGGAG TTTATTCGGA AAAGCCAGCT GGTCCAGCCT 
GTGGGGCCAC TGGTGGTGCT GCTGCCCCTG GCGGGTGGGT ACAGCCGCGT CCTCAACGCC 
GCCTGCCAGC GCCTGGCGAG GGCTGGGGTT GTGCTGGTCA CCGCTGCCGG CAACTTCCGG 
GACGATGCCT GCCTCTACTC CCCAGCCTCA GCTCCCGAGG TCATCACAGT TGGGGCCACC 
AATGCCCAGG ACCAGCCGGT GACCCTGGGG ACTTTGGGGA CCAACTTTGG CCGCTGTGTG 
GACCTCTTTG CCCCAGGGGA GGACATCATT GGTGCCTCCA GCGACTGCAG CACCTGCTTT 
GTGTCACAGA GTGGGACATC ACAGGCTGCT GCCCACGTGG CTGGCATTGC AGCCATGATG 
CTGTCTGCCG AGCCGGAGCT CACCCTGGCC GAGTTGAGGC AGAGACTGAT CCACTTCTCT 
GCCAAAGATG TCATCAATGA GGCCTGGTTC CCTGAGGACC AGCGGGTACT GACCCCTAAC 
CTGGTGGCCG CCCTGCCCCC CAGCACCCAT GGGGCAGGTT GGCAGCTGTT TTGCAGGACT 
GTGTGGTCAG CACACTCGGG GCCTACACGG ATGGCCACAG CCGTCGCCCG CTGCGCCCCA 
GATGAGGAGC TGCTGAGCTG CTCCAGTTTC TCCAGGAGTG GGAAGCGGCG GGGCGAGCGC 
ATGGAGGCCC AAGGGGGCAA GCTGGTCTGC CGGGCCCACA ACGCTTTTGG GGGTGAGGGT 
GTCTACGCCA TTGCCAGGTG CTGCCTGCTA CCCCAGGCCA ACTGCAGCAT CCACACAGCT 
CCACCAGCTG AGGCCGGCAT GGGGACCCGT GTCCACTGCC ACCAACAGGG CCACGTCCTC 
ACAGGTTTCC TAGCTCTTGC CTCAGACCTT AAAGAGAGAG GGTCTGATGG GGATGGGCAC 
TGGAGACGGA GCATCCCAGC ATTTCACATC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PCSK9 ( XM_024347585.1 ) cDNA ORF clone, Pan troglodytes(chimpanzee) -> XP_024203353.1 Pan troglodytes proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OPc91983
Clone ID Related Accession (Same CDS sequence)	XM_024347585.1
Accession Version	XM_024347585.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2361bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1521388800000
Organism	Pan troglodytes(chimpanzee)
Product	proprotein convertase subtilisin/kexin type 9 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_036879.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Pan troglodytes Annotation Release 105 Annotation Version :: 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGGCTCT GGTGGCGTGA TCTGCGCGCC CCAGGCGTCA AGCACCCACA CCCTAGAAGG 
TTTCCGCAGC GACGTCGAGG CGCTCGTGGT TGCAGGCGGG CGCCGCCGTT CAGTTCAGGG 
TCCGAGCCTG GAGGAGTGAG CCAGGCAGTG AGACTGGCTC GGGCGGGCCG GGACGCGTCG 
TTGCAGCAGC GGCTCCCAGC TCCCAGCCAG GATTCCGCGC GCCCCTTCAC GCGCCCTGCT 
CCTGAACTTC AGCTCCTGCG CAGTCCTCCC CACCGCAAGG CTCAAGGCGC CGCCGGCGTG 
GACCGCACAC GGCCTCTAGG TCTCCTCGCC AGGACAGCAA CCTCTCCCCT GGCCCTCATG 
GGCACCGTCA GCTCCAGGCG GTCCTGGTGG CCGCTGCCAC TGCTGCTGCT GCTGCTGCTG 
CTCCTGGGTC CCGCGGGCGC CCGTGCGCAG GAGGACGAGG ACGGCGACTA CGAGGAGCTG 
GTGCTAGCCT TGCGTTCCGA GGAGGACGGC CTGGCCGAAG CACCCGAGCA CGGAACCACA 
GCCACCTTCC ACCGCTGCGC CAAGGATCTG TGGAGGTTGC CTGGCACCTA CGTGGTGGTG 
CTGAAGGAGG AGACCCACCT CTCGCAGTCA GAGCGCACTG CCCGCCGCCT GCAGGCCCAA 
GCTGCCCGCC GAGGATACCT CACCAAGATC CTGCATGTCT TCCATGGCCT TCTTCCTGGC 
TTCCTGGTGA AGATGAGTGG TGACCTGCTG GAGCTGGCCT TGAAGTTGCC CCATGTCGAC 
TACATCGAGG AGGACTCCTC TGTCTTTGCC CAGAGCATCC CGTGGAACCT GGAGCGGATT 
ACCCCTCCAC GGTACCGGGC GGATGAATAC CAGCCCCCCG ATGGAGGCAG CCTGGTGGAG 
GTGTATCTCC TAGACACCAG CATACAGAGT GACCACCGGG AAATCGAGGG CAGGGTCATG 
GTCACCGACT TCGAGAATGT GCCCGAGGAG GACGGGACCC GCTTCCACAG ACAGGCCAGC 
AAGTGTGACA GTCATGGCAC CCACCTGGCA GGGGTGGTCA GCGGCCGGGA TGCCGGCGTG 
GCCAAGGGTG CCAGCATGCG CAGCCTGCGC GTGCTCAACT GCCAAGGGAA GGGCACGGTT 
AGCGGCACCC TCATAGGCCT GGAGTTTATT CGGAAAAGCC AGCTGGTCCA GCCTGTGGGG 
CCACTGGTGG TGCTGCTGCC CCTGGCGGGT GGGTACAGCC GCGTCCTCAA CGCCGCCTGC 
CAGCGCCTGG CGAGGGCTGG GGTTGTGCTG GTCACCGCTG CCGGCAACTT CCGGGACGAT 
GCCTGCCTCT ACTCCCCAGC CTCAGCTCCC GAGGTCATCA CAGTTGGGGC CACCAATGCC 
CAGGACCAGC CGGTGACCCT GGGGACTTTG GGGACCAACT TTGGCCGCTG TGTGGACCTC 
TTTGCCCCAG GGGAGGACAT CATTGGTGCC TCCAGCGACT GCAGCACCTG CTTTGTGTCA 
CAGAGTGGGA CATCACAGGC TGCTGCCCAC GTGGCTGGCA TTGCAGCCAT GATGCTGTCT 
GCCGAGCCGG AGCTCACCCT GGCCGAGTTG AGGCAGAGAC TGATCCACTT CTCTGCCAAA 
GATGTCATCA ATGAGGCCTG GTTCCCTGAG GACCAGCGGG TACTGACCCC TAACCTGGTG 
GCCGCCCTGC CCCCCAGCAC CCATGGGGCA GGTTGGCAGC TGTTTTGCAG GACTGTGTGG 
TCAGCACACT CGGGGCCTAC ACGGATGGCC ACAGCCGTCG CCCGCTGCGC CCCAGATGAG 
GAGCTGCTGA GCTGCTCCAG TTTCTCCAGG AGTGGGAAGC GGCGGGGCGA GCGCATGGAG 
GGCTGGCCAG ACCAGGAGTG GGGCACTCCC CACCTCACGC GGCTGGGGGC TGCTGGAGAG 
AGCCACAGCG GGAAGGGTTT CCTAGAGGCT GCAGGACAGT GCTGGATGGA TTTTCAATGC 
TCACCTGGGT GTGAGCGTGC GGCAGGGCCG CGTGAAGGTC AGCGATCTGC TACTCTGGAC 
TCAGCCATCT CTAGGCCCCT CTCACTCAGG TGCTCCATGG TTCTGGGAGC TGAGAAATCT 
CAAACCAGCA AAAAAGTGGA ATTGATGTTG ATGCTACAGG ATAGTGCACA GATGCCATCT 
GGTTGCAGCA TTTTGGTGGA AGGGCAGTGC CCAGCTAGGA GAGTGAGGAG GGGCAGGCAT 
TTCTGGCTTG GGAGATGGGG TCTTAATGCT CGTGTGAGAG GCAGAGTGGG TGGAGTGGAG 
CTGGCTGGGT CCTTGCTTTG GCCTCCTGGA TTTCTCTCTA TCTCCATTTT GAAACCACTC 
TGTGTTTGGA AGAACTTTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024203353.1
CDS	151..2511
Translation	MGLWWRDLRAPGVKHPHPRRFPQRRRGARGCRRAPPFSSGSEPGGVSQAVRLARAGRDASLQQRLPAPSQDSARPFTRPAPELQLLRSPPHRKAQGAAGVDRTRPLGLLARTATSPLALMGTVSSRRSWWPLPLLLLLLLLLGPAGARAQEDEDGDYEELVLALRSEEDGLAEAPEHGTTATFHRCAKDLWRLPGTYVVVLKEETHLSQSERTARRLQAQAARRGYLTKILHVFHGLLPGFLVKMSGDLLELALKLPHVDYIEEDSSVFAQSIPWNLERITPPRYRADEYQPPDGGSLVEVYLLDTSIQSDHREIEGRVMVTDFENVPEEDGTRFHRQASKCDSHGTHLAGVVSGRDAGVAKGASMRSLRVLNCQGKGTVSGTLIGLEFIRKSQLVQPVGPLVVLLPLAGGYSRVLNAACQRLARAGVVLVTAAGNFRDDACLYSPASAPEVITVGATNAQDQPVTLGTLGTNFGRCVDLFAPGEDIIGASSDCSTCFVSQSGTSQAAAHVAGIAAMMLSAEPELTLAELRQRLIHFSAKDVINEAWFPEDQRVLTPNLVAALPPSTHGAGWQLFCRTVWSAHSGPTRMATAVARCAPDEELLSCSSFSRSGKRRGERMEGWPDQEWGTPHLTRLGAAGESHSGKGFLEAAGQCWMDFQCSPGCERAAGPREGQRSATLDSAISRPLSLRCSMVLGAEKSQTSKKVELMLMLQDSAQMPSGCSILVEGQCPARRVRRGRHFWLGRWGLNARVRGRVGGVELAGSLLWPPGFLSISILKPLCVWKNF

Target ORF information:

RefSeq Version	XM_024347585.1
Organism	Pan troglodytes(chimpanzee)
Definition	Pan troglodytes proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024347585.1

ORF Insert Sequence:

ATGGGGCTCT GGTGGCGTGA TCTGCGCGCC CCAGGCGTCA AGCACCCACA CCCTAGAAGG 
TTTCCGCAGC GACGTCGAGG CGCTCGTGGT TGCAGGCGGG CGCCGCCGTT CAGTTCAGGG 
TCCGAGCCTG GAGGAGTGAG CCAGGCAGTG AGACTGGCTC GGGCGGGCCG GGACGCGTCG 
TTGCAGCAGC GGCTCCCAGC TCCCAGCCAG GATTCCGCGC GCCCCTTCAC GCGCCCTGCT 
CCTGAACTTC AGCTCCTGCG CAGTCCTCCC CACCGCAAGG CTCAAGGCGC CGCCGGCGTG 
GACCGCACAC GGCCTCTAGG TCTCCTCGCC AGGACAGCAA CCTCTCCCCT GGCCCTCATG 
GGCACCGTCA GCTCCAGGCG GTCCTGGTGG CCGCTGCCAC TGCTGCTGCT GCTGCTGCTG 
CTCCTGGGTC CCGCGGGCGC CCGTGCGCAG GAGGACGAGG ACGGCGACTA CGAGGAGCTG 
GTGCTAGCCT TGCGTTCCGA GGAGGACGGC CTGGCCGAAG CACCCGAGCA CGGAACCACA 
GCCACCTTCC ACCGCTGCGC CAAGGATCTG TGGAGGTTGC CTGGCACCTA CGTGGTGGTG 
CTGAAGGAGG AGACCCACCT CTCGCAGTCA GAGCGCACTG CCCGCCGCCT GCAGGCCCAA 
GCTGCCCGCC GAGGATACCT CACCAAGATC CTGCATGTCT TCCATGGCCT TCTTCCTGGC 
TTCCTGGTGA AGATGAGTGG TGACCTGCTG GAGCTGGCCT TGAAGTTGCC CCATGTCGAC 
TACATCGAGG AGGACTCCTC TGTCTTTGCC CAGAGCATCC CGTGGAACCT GGAGCGGATT 
ACCCCTCCAC GGTACCGGGC GGATGAATAC CAGCCCCCCG ATGGAGGCAG CCTGGTGGAG 
GTGTATCTCC TAGACACCAG CATACAGAGT GACCACCGGG AAATCGAGGG CAGGGTCATG 
GTCACCGACT TCGAGAATGT GCCCGAGGAG GACGGGACCC GCTTCCACAG ACAGGCCAGC 
AAGTGTGACA GTCATGGCAC CCACCTGGCA GGGGTGGTCA GCGGCCGGGA TGCCGGCGTG 
GCCAAGGGTG CCAGCATGCG CAGCCTGCGC GTGCTCAACT GCCAAGGGAA GGGCACGGTT 
AGCGGCACCC TCATAGGCCT GGAGTTTATT CGGAAAAGCC AGCTGGTCCA GCCTGTGGGG 
CCACTGGTGG TGCTGCTGCC CCTGGCGGGT GGGTACAGCC GCGTCCTCAA CGCCGCCTGC 
CAGCGCCTGG CGAGGGCTGG GGTTGTGCTG GTCACCGCTG CCGGCAACTT CCGGGACGAT 
GCCTGCCTCT ACTCCCCAGC CTCAGCTCCC GAGGTCATCA CAGTTGGGGC CACCAATGCC 
CAGGACCAGC CGGTGACCCT GGGGACTTTG GGGACCAACT TTGGCCGCTG TGTGGACCTC 
TTTGCCCCAG GGGAGGACAT CATTGGTGCC TCCAGCGACT GCAGCACCTG CTTTGTGTCA 
CAGAGTGGGA CATCACAGGC TGCTGCCCAC GTGGCTGGCA TTGCAGCCAT GATGCTGTCT 
GCCGAGCCGG AGCTCACCCT GGCCGAGTTG AGGCAGAGAC TGATCCACTT CTCTGCCAAA 
GATGTCATCA ATGAGGCCTG GTTCCCTGAG GACCAGCGGG TACTGACCCC TAACCTGGTG 
GCCGCCCTGC CCCCCAGCAC CCATGGGGCA GGTTGGCAGC TGTTTTGCAG GACTGTGTGG 
TCAGCACACT CGGGGCCTAC ACGGATGGCC ACAGCCGTCG CCCGCTGCGC CCCAGATGAG 
GAGCTGCTGA GCTGCTCCAG TTTCTCCAGG AGTGGGAAGC GGCGGGGCGA GCGCATGGAG 
GGCTGGCCAG ACCAGGAGTG GGGCACTCCC CACCTCACGC GGCTGGGGGC TGCTGGAGAG 
AGCCACAGCG GGAAGGGTTT CCTAGAGGCT GCAGGACAGT GCTGGATGGA TTTTCAATGC 
TCACCTGGGT GTGAGCGTGC GGCAGGGCCG CGTGAAGGTC AGCGATCTGC TACTCTGGAC 
TCAGCCATCT CTAGGCCCCT CTCACTCAGG TGCTCCATGG TTCTGGGAGC TGAGAAATCT 
CAAACCAGCA AAAAAGTGGA ATTGATGTTG ATGCTACAGG ATAGTGCACA GATGCCATCT 
GGTTGCAGCA TTTTGGTGGA AGGGCAGTGC CCAGCTAGGA GAGTGAGGAG GGGCAGGCAT 
TTCTGGCTTG GGAGATGGGG TCTTAATGCT CGTGTGAGAG GCAGAGTGGG TGGAGTGGAG 
CTGGCTGGGT CCTTGCTTTG GCCTCCTGGA TTTCTCTCTA TCTCCATTTT GAAACCACTC 
TGTGTTTGGA AGAACTTTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PCSK9 ( XM_016953243.2 ) cDNA ORF clone, Pan troglodytes(chimpanzee) -> XP_016808732.2 Pan troglodytes proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant X2, mRNA.

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CloneID	OPc91984
Clone ID Related Accession (Same CDS sequence)	XM_016953243.2
Accession Version	XM_016953243.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2127bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1521388800000
Organism	Pan troglodytes(chimpanzee)
Product	proprotein convertase subtilisin/kexin type 9 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_036879.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 20, 2018 this sequence version replaced XM_016953243.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Pan troglodytes Annotation Release 105 Annotation Version :: 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGGCTCT GGTGGCGTGA TCTGCGCGCC CCAGGCGTCA AGCACCCACA CCCTAGAAGG 
TTTCCGCAGC GACGTCGAGG CGCTCGTGGT TGCAGGCGGG CGCCGCCGTT CAGTTCAGGG 
TCCGAGCCTG GAGGAGTGAG CCAGGCAGTG AGACTGGCTC GGGCGGGCCG GGACGCGTCG 
TTGCAGCAGC GGCTCCCAGC TCCCAGCCAG GATTCCGCGC GCCCCTTCAC GCGCCCTGCT 
CCTGAACTTC AGCTCCTGCG CAGTCCTCCC CACCGCAAGG CTCAAGGCGC CGCCGGCGTG 
GACCGCACAC GGCCTCTAGG TCTCCTCGCC AGGACAGCAA CCTCTCCCCT GGCCCTCATG 
GGCACCGTCA GCTCCAGGCG GTCCTGGTGG CCGCTGCCAC TGCTGCTGCT GCTGCTGCTG 
CTCCTGGGTC CCGCGGGCGC CCGTGCGCAG GAGGACGAGG ACGGCGACTA CGAGGAGCTG 
GTGCTAGCCT TGCGTTCCGA GGAGGACGGC CTGGCCGAAG CACCCGAGCA CGGAACCACA 
GCCACCTTCC ACCGCTGCGC CAAGGATCTG TGGAGGTTGC CTGGCACCTA CGTGGTGGTG 
CTGAAGGAGG AGACCCACCT CTCGCAGTCA GAGCGCACTG CCCGCCGCCT GCAGGCCCAA 
GCTGCCCGCC GAGGATACCT CACCAAGATC CTGCATGTCT TCCATGGCCT TCTTCCTGGC 
TTCCTGGTGA AGATGAGTGG TGACCTGCTG GAGCTGGCCT TGAAGTTGCC CCATGTCGAC 
TACATCGAGG AGGACTCCTC TGTCTTTGCC CAGAGCATCC CGTGGAACCT GGAGCGGATT 
ACCCCTCCAC GGTACCGGGC GGATGAATAC CAGCCCCCCG ATGGAGGCAG CCTGGTGGAG 
GTGTATCTCC TAGACACCAG CATACAGAGT GACCACCGGG AAATCGAGGG CAGGGTCATG 
GTCACCGACT TCGAGAATGT GCCCGAGGAG GACGGGACCC GCTTCCACAG ACAGGCCAGC 
AAGTGTGACA GTCATGGCAC CCACCTGGCA GGGGTGGTCA GCGGCCGGGA TGCCGGCGTG 
GCCAAGGGTG CCAGCATGCG CAGCCTGCGC GTGCTCAACT GCCAAGGGAA GGGCACGGTT 
AGCGGCACCC TCATAGGCCT GGAGTTTATT CGGAAAAGCC AGCTGGTCCA GCCTGTGGGG 
CCACTGGTGG TGCTGCTGCC CCTGGCGGGT GGGTACAGCC GCGTCCTCAA CGCCGCCTGC 
CAGCGCCTGG CGAGGGCTGG GGTTGTGCTG GTCACCGCTG CCGGCAACTT CCGGGACGAT 
GCCTGCCTCT ACTCCCCAGC CTCAGCTCCC GAGGTCATCA CAGTTGGGGC CACCAATGCC 
CAGGACCAGC CGGTGACCCT GGGGACTTTG GGGACCAACT TTGGCCGCTG TGTGGACCTC 
TTTGCCCCAG GGGAGGACAT CATTGGTGCC TCCAGCGACT GCAGCACCTG CTTTGTGTCA 
CAGAGTGGGA CATCACAGGC TGCTGCCCAC GTGGCTGGCA TTGCAGCCAT GATGCTGTCT 
GCCGAGCCGG AGCTCACCCT GGCCGAGTTG AGGCAGAGAC TGATCCACTT CTCTGCCAAA 
GATGTCATCA ATGAGGCCTG GTTCCCTGAG GACCAGCGGG TACTGACCCC TAACCTGGTG 
GCCGCCCTGC CCCCCAGCAC CCATGGGGCA GGTTGGCAGC TGTTTTGCAG GACTGTGTGG 
TCAGCACACT CGGGGCCTAC ACGGATGGCC ACAGCCGTCG CCCGCTGCGC CCCAGATGAG 
GAGCTGCTGA GCTGCTCCAG TTTCTCCAGG AGTGGGAAGC GGCGGGGCGA GCGCATGGAG 
GCCCAAGGGG GCAAGCTGGT CTGCCGGGCC CACAACGCTT TTGGGGGTGA GGGTGTCTAC 
GCCATTGCCA GGTGCTGCCT GCTACCCCAG GCCAACTGCA GCATCCACAC AGCTCCACCA 
GCTGAGGCCG GCATGGGGAC CCGTGTCCAC TGCCACCAAC AGGGCCACGT CCTCACAGGT 
TTCCTAGCTC TTGCCTCAGA CCTTAAAGAG AGAGGGTCTG ATGGGGATGG GCACTGGAGA 
CGGAGCATCC CAGCATTTCA CATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016808732.2
CDS	107..2233
Translation	MGLWWRDLRAPGVKHPHPRRFPQRRRGARGCRRAPPFSSGSEPGGVSQAVRLARAGRDASLQQRLPAPSQDSARPFTRPAPELQLLRSPPHRKAQGAAGVDRTRPLGLLARTATSPLALMGTVSSRRSWWPLPLLLLLLLLLGPAGARAQEDEDGDYEELVLALRSEEDGLAEAPEHGTTATFHRCAKDLWRLPGTYVVVLKEETHLSQSERTARRLQAQAARRGYLTKILHVFHGLLPGFLVKMSGDLLELALKLPHVDYIEEDSSVFAQSIPWNLERITPPRYRADEYQPPDGGSLVEVYLLDTSIQSDHREIEGRVMVTDFENVPEEDGTRFHRQASKCDSHGTHLAGVVSGRDAGVAKGASMRSLRVLNCQGKGTVSGTLIGLEFIRKSQLVQPVGPLVVLLPLAGGYSRVLNAACQRLARAGVVLVTAAGNFRDDACLYSPASAPEVITVGATNAQDQPVTLGTLGTNFGRCVDLFAPGEDIIGASSDCSTCFVSQSGTSQAAAHVAGIAAMMLSAEPELTLAELRQRLIHFSAKDVINEAWFPEDQRVLTPNLVAALPPSTHGAGWQLFCRTVWSAHSGPTRMATAVARCAPDEELLSCSSFSRSGKRRGERMEAQGGKLVCRAHNAFGGEGVYAIARCCLLPQANCSIHTAPPAEAGMGTRVHCHQQGHVLTGFLALASDLKERGSDGDGHWRRSIPAFHI

Target ORF information:

RefSeq Version	XM_016953243.2
Organism	Pan troglodytes(chimpanzee)
Definition	Pan troglodytes proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_016953243.2

ORF Insert Sequence:

ATGGGGCTCT GGTGGCGTGA TCTGCGCGCC CCAGGCGTCA AGCACCCACA CCCTAGAAGG 
TTTCCGCAGC GACGTCGAGG CGCTCGTGGT TGCAGGCGGG CGCCGCCGTT CAGTTCAGGG 
TCCGAGCCTG GAGGAGTGAG CCAGGCAGTG AGACTGGCTC GGGCGGGCCG GGACGCGTCG 
TTGCAGCAGC GGCTCCCAGC TCCCAGCCAG GATTCCGCGC GCCCCTTCAC GCGCCCTGCT 
CCTGAACTTC AGCTCCTGCG CAGTCCTCCC CACCGCAAGG CTCAAGGCGC CGCCGGCGTG 
GACCGCACAC GGCCTCTAGG TCTCCTCGCC AGGACAGCAA CCTCTCCCCT GGCCCTCATG 
GGCACCGTCA GCTCCAGGCG GTCCTGGTGG CCGCTGCCAC TGCTGCTGCT GCTGCTGCTG 
CTCCTGGGTC CCGCGGGCGC CCGTGCGCAG GAGGACGAGG ACGGCGACTA CGAGGAGCTG 
GTGCTAGCCT TGCGTTCCGA GGAGGACGGC CTGGCCGAAG CACCCGAGCA CGGAACCACA 
GCCACCTTCC ACCGCTGCGC CAAGGATCTG TGGAGGTTGC CTGGCACCTA CGTGGTGGTG 
CTGAAGGAGG AGACCCACCT CTCGCAGTCA GAGCGCACTG CCCGCCGCCT GCAGGCCCAA 
GCTGCCCGCC GAGGATACCT CACCAAGATC CTGCATGTCT TCCATGGCCT TCTTCCTGGC 
TTCCTGGTGA AGATGAGTGG TGACCTGCTG GAGCTGGCCT TGAAGTTGCC CCATGTCGAC 
TACATCGAGG AGGACTCCTC TGTCTTTGCC CAGAGCATCC CGTGGAACCT GGAGCGGATT 
ACCCCTCCAC GGTACCGGGC GGATGAATAC CAGCCCCCCG ATGGAGGCAG CCTGGTGGAG 
GTGTATCTCC TAGACACCAG CATACAGAGT GACCACCGGG AAATCGAGGG CAGGGTCATG 
GTCACCGACT TCGAGAATGT GCCCGAGGAG GACGGGACCC GCTTCCACAG ACAGGCCAGC 
AAGTGTGACA GTCATGGCAC CCACCTGGCA GGGGTGGTCA GCGGCCGGGA TGCCGGCGTG 
GCCAAGGGTG CCAGCATGCG CAGCCTGCGC GTGCTCAACT GCCAAGGGAA GGGCACGGTT 
AGCGGCACCC TCATAGGCCT GGAGTTTATT CGGAAAAGCC AGCTGGTCCA GCCTGTGGGG 
CCACTGGTGG TGCTGCTGCC CCTGGCGGGT GGGTACAGCC GCGTCCTCAA CGCCGCCTGC 
CAGCGCCTGG CGAGGGCTGG GGTTGTGCTG GTCACCGCTG CCGGCAACTT CCGGGACGAT 
GCCTGCCTCT ACTCCCCAGC CTCAGCTCCC GAGGTCATCA CAGTTGGGGC CACCAATGCC 
CAGGACCAGC CGGTGACCCT GGGGACTTTG GGGACCAACT TTGGCCGCTG TGTGGACCTC 
TTTGCCCCAG GGGAGGACAT CATTGGTGCC TCCAGCGACT GCAGCACCTG CTTTGTGTCA 
CAGAGTGGGA CATCACAGGC TGCTGCCCAC GTGGCTGGCA TTGCAGCCAT GATGCTGTCT 
GCCGAGCCGG AGCTCACCCT GGCCGAGTTG AGGCAGAGAC TGATCCACTT CTCTGCCAAA 
GATGTCATCA ATGAGGCCTG GTTCCCTGAG GACCAGCGGG TACTGACCCC TAACCTGGTG 
GCCGCCCTGC CCCCCAGCAC CCATGGGGCA GGTTGGCAGC TGTTTTGCAG GACTGTGTGG 
TCAGCACACT CGGGGCCTAC ACGGATGGCC ACAGCCGTCG CCCGCTGCGC CCCAGATGAG 
GAGCTGCTGA GCTGCTCCAG TTTCTCCAGG AGTGGGAAGC GGCGGGGCGA GCGCATGGAG 
GCCCAAGGGG GCAAGCTGGT CTGCCGGGCC CACAACGCTT TTGGGGGTGA GGGTGTCTAC 
GCCATTGCCA GGTGCTGCCT GCTACCCCAG GCCAACTGCA GCATCCACAC AGCTCCACCA 
GCTGAGGCCG GCATGGGGAC CCGTGTCCAC TGCCACCAAC AGGGCCACGT CCTCACAGGT 
TTCCTAGCTC TTGCCTCAGA CCTTAAAGAG AGAGGGTCTG ATGGGGATGG GCACTGGAGA 
CGGAGCATCC CAGCATTTCA CATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Ossabaw Pigs With a PCSK9 Gain-of-Function Mutation Develop Accelerated Coronary Atherosclerotic Lesions: A Novel Model for Preclinical Studies.
Journal of the American Heart Association7(6)(2018 03)
Yuan F,Guo L,Park KH,Woollard JR,Taek-Geun K,Jiang K,Melkamu T,Zang B,Smith SL,Fahrenkrug SC,Kolodgie FD,Lerman A,Virmani R,Lerman LO,Carlson DF

Evidence for positive selection in the C-terminal domain of the cholesterol metabolism gene PCSK9 based on phylogenetic analysis in 14 primate species.
PloS one2(10)e1098(2007 Oct)
Ding K,McDonough SJ,Kullo IJ

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PCSK9 cDNA ORF clone, Pan troglodytes(chimpanzee)

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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