Nadk2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Nadk2
Entrez Gene ID	68646
Full Name	NAD kinase 2, mitochondrial
Synonyms	MNADK,Nadkd1
General protein information	Preferred Names NAD kinase 2, mitochondrial Names NAD kinase 2, mitochondrial NAD kinase domain-containing protein 1, mitochondrial
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 15 Map Location: 15\|15 A1

mRNA and Protein(s)

mRNA	Protein	Name
NM_001040395.4	NP_001035485.2	NAD kinase 2, mitochondrial isoform 2
NM_001286255.1	NP_001273184.1	NAD kinase 2, mitochondrial isoform 4
NM_001085410.2	NP_001078879.1	NAD kinase 2, mitochondrial isoform 1
NM_001286253.1	NP_001273182.1	NAD kinase 2, mitochondrial isoform 3

Pathways from BioSystems

Homologies

Anopheles gambiae (African malaria mosquito)	AgaP_AGAP006767	XP_308978.4
Pan troglodytes (chimpanzee)	NADKD1	XP_517804.3
Canis lupus familiaris (dog)	NADK2	XP_005619442.1
Danio rerio (zebrafish)	nadk2	NP_001003465.1
Caenorhabditis elegans (roundworm)	Y17G7B.10	NP_496566.1
Bos taurus (cattle)	NADKD1	NP_001243482.1
Drosophila melanogaster (fruit fly)	CG8080	NP_001260815.1
Xenopus tropicalis (tropical clawed frog)	nadk2	NP_001072687.1
Macaca mulatta (Rhesus monkey)	NADKD1	XP_001092624.2
Rattus norvegicus (Norway rat)	Nadk2	NP_001037717.1
Gallus gallus (chicken)	NADKD1	XP_425010.3
Homo sapiens (human)	NADK2	NP_001078880.1
Mus musculus (house mouse)	Nadk2	NP_001078879.1

Gene Ontology
Bibliography

Related articles in PubMed

Placentation defects are highly prevalent in embryonic lethal mouse mutants.
Perez-Garcia V, Fineberg E, Wilson R, Murray A, Mazzeo CI, Tudor C, Sienerth A, White JK, Tuck E, Ryder EJ, Gleeson D, Siragher E, Wardle-Jones H, Staudt N, Wali N, Collins J, Geyer S, Busch-Nentwich EM, Galli A, Smith JC, Robertson E, Adams DJ, Weninger WJ, Mohun T, Hemberger M
Nature555(7697)463-468(2018 03)

Deficiency of the Mitochondrial NAD Kinase Causes Stress-Induced Hepatic Steatosis in Mice.
Zhang K, Kim H, Fu Z, Qiu Y, Yang Z, Wang J, Zhang D, Tong X, Yin L, Li J, Wu J, Qi NR, Houten SM, Zhang R
Gastroenterology154(1)224-237(2018 01)

MNADK, a novel liver-enriched mitochondrion-localized NAD kinase.
Zhang R
Biology open2(4)432-8(2013 Apr)

Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration.
Lumayag S, Haldin CE, Corbett NJ, Wahlin KJ, Cowan C, Turturro S, Larsen PE, Kovacs B, Witmer PD, Valle D, Zack DJ, Nicholson DA, Xu S
Proceedings of the National Academy of Sciences of the United States of America110(6)E507-16(2013 Feb)

Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.
Mootha VK, Bunkenborg J, Olsen JV, Hjerrild M, Wisniewski JR, Stahl E, Bolouri MS, Ray HN, Sihag S, Kamal M, Patterson N, Lander ES, Mann M
Cell115(5)629-40(2003 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Nadk2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nadk2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu13764	NM_001286255.1 Latest version!	Mus musculus NAD kinase 2, mitochondrial (Nadk2), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OMu14009	NM_001286253.1 Latest version!	Mus musculus NAD kinase 2, mitochondrial (Nadk2), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OMu17208	NM_001085410.2 Latest version!	Mus musculus NAD kinase 2, mitochondrial (Nadk2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OMu17324	NM_001040395.4 Latest version!	Mus musculus NAD kinase 2, mitochondrial (Nadk2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00

ORF Online Only Promotion

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2-4 Clone	40% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Nadk2 ( NM_001286255.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001273184.1 Mus musculus NAD kinase 2, mitochondrial (Nadk2), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OMu13764
Clone ID Related Accession (Same CDS sequence)	NM_001286255.1
Accession Version	NM_001286255.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1209bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1571414400000
Organism	Mus musculus(house mouse)
Product	NAD kinase 2, mitochondrial isoform 4
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK046666.1, AK078318.1, AK162601.1, AW537715.1, BE692075.1 and BY545448.1. Transcript Variant: This variant (4) lacks two in-frame exons in the central coding region, compared to variant 1. The encoded isoform (4) is shorter, compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: AK149267.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGACTTGCT ACCGGGGCTT CCTGCTGGGC AGCTGCCGGC GCGTGGCGGG TGGCCGCGCG 
GCTCTGCGGG GTTCGGGCTC GGGCGCGGAC GGCCGGCGGC ACTTGGGGCA CGGGCAGCCG 
CGCGAGCTGG CGGGCGGTGG TAGCCCCGCC GACGGCGGCT TCCGCCCCTC GCGGGTGGTG 
GTGGTGGCGA AAACCACCCG CTACGAGTTC GAGCAGCAGC GGTACCGCTA CGCGGAGCTC 
TCGGAGGAGG ACCTGAAGCA GCTGCTTGCA TTGAAAGGCT CGAGCTACAG TGGACTACTT 
GAGCGACATC ATATTCACAC CAAAAATGTA GAACACATAA TTGATAGTTT ACGGGATGAA 
GGGATTGAGG TTCGCCTGGT CAAGCGGAGG GAGTACGATG AAGAGACAGT TCGATGGGCA 
GACGCTGTCA TAGCTGCGGG AGGTGATGGC ACGATGCTTC TGGCTGCGAG TAAAGTCCTG 
GACAGACTTA AACCTGTCAT TGGGGTCAAC ACTGATCCGG AACGGTGGTT GTGGAGGCAG 
CGGATCAGGT TATATCTGGA AGGGACTGGC ATAAACCCCA CTCCCGTGGA CCTTCACGAA 
CAGCAGCTGA GCTTGAATCA GCACAGCCGA GCCTTTAACA TCGAAAGAGC GCACGATGAA 
AGGTCGGAGG CGTCAGGGCC TCAGCTTCTG CCGGTGAGAG CGCTCAATGA AGTCTTCATT 
GGGGAGAGCC TGTCATCCAG GGCTTCCTAC TATGAAATTT CAGTCGATGA CGGCCCATGG 
GAGAAGCAGA AGAGCTCAGG GCTCAATTTG TGCACTGGGA CAGGATCGAA GGCCTGGTCA 
TTCAATATTA ACAGGGTTGC AGCGCAGGCT GTTGAAGATG TTTTACATAT TGCAAGACGA 
CAAGGAAATC TGACTCTTCC ATTGAACAAA GACTTGGTAG AAAAAGTGAC AAACGAATAT 
AACGAATCAT TGCTCTACAG TCCAGAAGAA CCAAAAATAC TTTTCAGTAT TCGAGAGCCA 
ATAGCAAACA GAGTTTTCTC CAGCAGCCGT CAGCGTTGTT TCTCTTCCAA AGTTTGTGTT 
CGTTCTCGAT GTTGGGATGC CTGCATGGTT GTGGATGGAG GAACGTCTTT TGAGTTTAAC 
GACGGAGCAA TTGCTTCAAT GATGATCAAT AAAGAAGATG AGCTTCGAAC TGTGATTCTA 
GAGCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001273184.1
CDS	243..1451
Translation	MTCYRGFLLGSCRRVAGGRAALRGSGSGADGRRHLGHGQPRELAGGGSPADGGFRPSRVVVVAKTTRYEFEQQRYRYAELSEEDLKQLLALKGSSYSGLLERHHIHTKNVEHIIDSLRDEGIEVRLVKRREYDEETVRWADAVIAAGGDGTMLLAASKVLDRLKPVIGVNTDPERWLWRQRIRLYLEGTGINPTPVDLHEQQLSLNQHSRAFNIERAHDERSEASGPQLLPVRALNEVFIGESLSSRASYYEISVDDGPWEKQKSSGLNLCTGTGSKAWSFNINRVAAQAVEDVLHIARRQGNLTLPLNKDLVEKVTNEYNESLLYSPEEPKILFSIREPIANRVFSSSRQRCFSSKVCVRSRCWDACMVVDGGTSFEFNDGAIASMMINKEDELRTVILEQ

Target ORF information:

RefSeq Version	NM_001286255.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus NAD kinase 2, mitochondrial (Nadk2), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001286255.1

ORF Insert Sequence:

ATGACTTGCT ACCGGGGCTT CCTGCTGGGC AGCTGCCGGC GCGTGGCGGG TGGCCGCGCG 
GCTCTGCGGG GTTCGGGCTC GGGCGCGGAC GGCCGGCGGC ACTTGGGGCA CGGGCAGCCG 
CGCGAGCTGG CGGGCGGTGG TAGCCCCGCC GACGGCGGCT TCCGCCCCTC GCGGGTGGTG 
GTGGTGGCGA AAACCACCCG CTACGAGTTC GAGCAGCAGC GGTACCGCTA CGCGGAGCTC 
TCGGAGGAGG ACCTGAAGCA GCTGCTTGCA TTGAAAGGCT CGAGCTACAG TGGACTACTT 
GAGCGACATC ATATTCACAC CAAAAATGTA GAACACATAA TTGATAGTTT ACGGGATGAA 
GGGATTGAGG TTCGCCTGGT CAAGCGGAGG GAGTACGATG AAGAGACAGT TCGATGGGCA 
GACGCTGTCA TAGCTGCGGG AGGTGATGGC ACGATGCTTC TGGCTGCGAG TAAAGTCCTG 
GACAGACTTA AACCTGTCAT TGGGGTCAAC ACTGATCCGG AACGGTGGTT GTGGAGGCAG 
CGGATCAGGT TATATCTGGA AGGGACTGGC ATAAACCCCA CTCCCGTGGA CCTTCACGAA 
CAGCAGCTGA GCTTGAATCA GCACAGCCGA GCCTTTAACA TCGAAAGAGC GCACGATGAA 
AGGTCGGAGG CGTCAGGGCC TCAGCTTCTG CCGGTGAGAG CGCTCAATGA AGTCTTCATT 
GGGGAGAGCC TGTCATCCAG GGCTTCCTAC TATGAAATTT CAGTCGATGA CGGCCCATGG 
GAGAAGCAGA AGAGCTCAGG GCTCAATTTG TGCACTGGGA CAGGATCGAA GGCCTGGTCA 
TTCAATATTA ACAGGGTTGC AGCGCAGGCT GTTGAAGATG TTTTACATAT TGCAAGACGA 
CAAGGAAATC TGACTCTTCC ATTGAACAAA GACTTGGTAG AAAAAGTGAC AAACGAATAT 
AACGAATCAT TGCTCTACAG TCCAGAAGAA CCAAAAATAC TTTTCAGTAT TCGAGAGCCA 
ATAGCAAACA GAGTTTTCTC CAGCAGCCGT CAGCGTTGTT TCTCTTCCAA AGTTTGTGTT 
CGTTCTCGAT GTTGGGATGC CTGCATGGTT GTGGATGGAG GAACGTCTTT TGAGTTTAAC 
GACGGAGCAA TTGCTTCAAT GATGATCAAT AAAGAAGATG AGCTTCGAAC TGTGATTCTA 
GAGCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Nadk2 ( NM_001286253.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001273182.1 Mus musculus NAD kinase 2, mitochondrial (Nadk2), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OMu14009
Clone ID Related Accession (Same CDS sequence)	NM_001286253.1
Accession Version	NM_001286253.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1158bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1571587200000
Organism	Mus musculus(house mouse)
Product	NAD kinase 2, mitochondrial isoform 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK046666.1, AK016988.1 and BF460794.1. Transcript Variant: This variant (3) lacks an in-frame exon in the central coding region, lacks several additional exons, and its 3' terminal exon extends past a splice site that is used in variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: AK003858.1, AK016988.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGACTTGCT ACCGGGGCTT CCTGCTGGGC AGCTGCCGGC GCGTGGCGGG TGGCCGCGCG 
GCTCTGCGGG GTTCGGGCTC GGGCGCGGAC GGCCGGCGGC ACTTGGGGCA CGGGCAGCCG 
CGCGAGCTGG CGGGCGGTGG TAGCCCCGCC GACGGCGGCT TCCGCCCCTC GCGGGTGGTG 
GTGGTGGCGA AAACCACCCG CTACGAGTTC GAGCAGCAGC GGTACCGCTA CGCGGAGCTC 
TCGGAGGAGG ACCTGAAGCA GCTGCTTGCA TTGAAAGGCT CGAGCTACAG TGGACTACTT 
GAGCGACATC ATATTCACAC CAAAAATGTA GAACACATAA TTGATAGTTT ACGGGATGAA 
GGGATTGAGG TTCGCCTGGT CAAGCGGAGG GAGTACGATG AAGAGACAGT TCGATGGGCA 
GACGCTGTCA TAGCTGCGGG AGGTGATGGC ACGATGCTTC TGGCTGCGAG TAAAGTCCTG 
GACAGACTTA AACCTGTCAT TGGGGTCAAC ACTGATCCGG AACGGTCTGA AGGTCACTTA 
TGTCTGCCTG TGCGATACAC GCATTCCTTC CCTGAAGCCT TACGGAGGTT CTCTCGTGGT 
GAGTTCAGGT GGTTGTGGAG GCAGCGGATC AGGTTATATC TGGAAGGGAC TGGCATAAAC 
CCCACTCCCG TGGACCTTCA CGAACAGCAG CTGAGCTTGA ATCAGCACAG CCGAGCCTTT 
AACATCGAAA GAGCGCACGA TGAAAGGTCG GAGGCGTCAG GGCCTCAGCT TCTGCCGGTG 
AGAGCGCTCA ATGAAGTCTT CATTGGGGAG AGCCTGTCAT CCAGGGCTTC CTACTATGAA 
ATTTCAGTCG ATGACGGCCC ATGGGAGAAG CAGAAGAGCT CAGGGCTCAA TTTGTGCACT 
GGGACAGGAT CGAAGGCCTG GTCATTCAAT ATTAACAGGG TTGCAGCGCA GGCTGTTGAA 
GATGTTTTAC ATATTGCAAG ACGACAAGGA AATCTGACTC TTCCATTGAA CAAAGACTTG 
GTAGAAAAAG TGACAAACGA ATATAACGAA TCATTGCTCT ACAGTCCAGA AGAACCAAAA 
ATACTTTTCA GTATTCGAGA GCCAATAGCA AACAGAGTTT TCTCCAGCAG CCGTCAGCGT 
TGTTTCTCTT CCAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001273182.1
CDS	243..1400
Translation	MTCYRGFLLGSCRRVAGGRAALRGSGSGADGRRHLGHGQPRELAGGGSPADGGFRPSRVVVVAKTTRYEFEQQRYRYAELSEEDLKQLLALKGSSYSGLLERHHIHTKNVEHIIDSLRDEGIEVRLVKRREYDEETVRWADAVIAAGGDGTMLLAASKVLDRLKPVIGVNTDPERSEGHLCLPVRYTHSFPEALRRFSRGEFRWLWRQRIRLYLEGTGINPTPVDLHEQQLSLNQHSRAFNIERAHDERSEASGPQLLPVRALNEVFIGESLSSRASYYEISVDDGPWEKQKSSGLNLCTGTGSKAWSFNINRVAAQAVEDVLHIARRQGNLTLPLNKDLVEKVTNEYNESLLYSPEEPKILFSIREPIANRVFSSSRQRCFSSK

Target ORF information:

RefSeq Version	NM_001286253.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus NAD kinase 2, mitochondrial (Nadk2), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001286253.1

ORF Insert Sequence:

ATGACTTGCT ACCGGGGCTT CCTGCTGGGC AGCTGCCGGC GCGTGGCGGG TGGCCGCGCG 
GCTCTGCGGG GTTCGGGCTC GGGCGCGGAC GGCCGGCGGC ACTTGGGGCA CGGGCAGCCG 
CGCGAGCTGG CGGGCGGTGG TAGCCCCGCC GACGGCGGCT TCCGCCCCTC GCGGGTGGTG 
GTGGTGGCGA AAACCACCCG CTACGAGTTC GAGCAGCAGC GGTACCGCTA CGCGGAGCTC 
TCGGAGGAGG ACCTGAAGCA GCTGCTTGCA TTGAAAGGCT CGAGCTACAG TGGACTACTT 
GAGCGACATC ATATTCACAC CAAAAATGTA GAACACATAA TTGATAGTTT ACGGGATGAA 
GGGATTGAGG TTCGCCTGGT CAAGCGGAGG GAGTACGATG AAGAGACAGT TCGATGGGCA 
GACGCTGTCA TAGCTGCGGG AGGTGATGGC ACGATGCTTC TGGCTGCGAG TAAAGTCCTG 
GACAGACTTA AACCTGTCAT TGGGGTCAAC ACTGATCCGG AACGGTCTGA AGGTCACTTA 
TGTCTGCCTG TGCGATACAC GCATTCCTTC CCTGAAGCCT TACGGAGGTT CTCTCGTGGT 
GAGTTCAGGT GGTTGTGGAG GCAGCGGATC AGGTTATATC TGGAAGGGAC TGGCATAAAC 
CCCACTCCCG TGGACCTTCA CGAACAGCAG CTGAGCTTGA ATCAGCACAG CCGAGCCTTT 
AACATCGAAA GAGCGCACGA TGAAAGGTCG GAGGCGTCAG GGCCTCAGCT TCTGCCGGTG 
AGAGCGCTCA ATGAAGTCTT CATTGGGGAG AGCCTGTCAT CCAGGGCTTC CTACTATGAA 
ATTTCAGTCG ATGACGGCCC ATGGGAGAAG CAGAAGAGCT CAGGGCTCAA TTTGTGCACT 
GGGACAGGAT CGAAGGCCTG GTCATTCAAT ATTAACAGGG TTGCAGCGCA GGCTGTTGAA 
GATGTTTTAC ATATTGCAAG ACGACAAGGA AATCTGACTC TTCCATTGAA CAAAGACTTG 
GTAGAAAAAG TGACAAACGA ATATAACGAA TCATTGCTCT ACAGTCCAGA AGAACCAAAA 
ATACTTTTCA GTATTCGAGA GCCAATAGCA AACAGAGTTT TCTCCAGCAG CCGTCAGCGT 
TGTTTCTCTT CCAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Nadk2 ( NM_001085410.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001078879.1 Mus musculus NAD kinase 2, mitochondrial (Nadk2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu17208
Clone ID Related Accession (Same CDS sequence)	NM_001085410.2
Accession Version	NM_001085410.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1359bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577376000000
Organism	Mus musculus(house mouse)
Product	NAD kinase 2, mitochondrial isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK046666.1, AK078318.1, AK162601.1, AW537715.1, BE692075.1 and BY545448.1. On Nov 1, 2013 this sequence version replaced NM_001085410.1. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). ##Evidence-Data-START## Transcript exon combination :: AK046666.1, SRR1660813.108864.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGACTTGCT ACCGGGGCTT CCTGCTGGGC AGCTGCCGGC GCGTGGCGGG TGGCCGCGCG 
GCTCTGCGGG GTTCGGGCTC GGGCGCGGAC GGCCGGCGGC ACTTGGGGCA CGGGCAGCCG 
CGCGAGCTGG CGGGCGGTGG TAGCCCCGCC GACGGCGGCT TCCGCCCCTC GCGGGTGGTG 
GTGGTGGCGA AAACCACCCG CTACGAGTTC GAGCAGCAGC GGTACCGCTA CGCGGAGCTC 
TCGGAGGAGG ACCTGAAGCA GCTGCTTGCA TTGAAAGGCT CGAGCTACAG TGGACTACTT 
GAGCGACATC ATATTCACAC CAAAAATGTA GAACACATAA TTGATAGTTT ACGGGATGAA 
GGGATTGAGG TTCGCCTGGT CAAGCGGAGG GAGTACGATG AAGAGACAGT TCGATGGGCA 
GACGCTGTCA TAGCTGCGGG AGGTGATGGC ACGATGCTTC TGGCTGCGAG TAAAGTCCTG 
GACAGACTTA AACCTGTCAT TGGGGTCAAC ACTGATCCGG AACGGTCTGA AGGTCACTTA 
TGTCTGCCTG TGCGATACAC GCATTCCTTC CCTGAAGCCT TACGGAGGTT CTCTCGTGGT 
GAGTTCAGGT GGTTGTGGAG GCAGCGGATC AGGTTATATC TGGAAGGGAC TGGCATAAAC 
CCCACTCCCG TGGACCTTCA CGAACAGCAG CTGAGCTTGA ATCAGCACAG CCGAGCCTTT 
AACATCGAAA GAGCGCACGA TGAAAGGTCG GAGGCGTCAG GGCCTCAGCT TCTGCCGGTG 
AGAGCGCTCA ATGAAGTCTT CATTGGGGAG AGCCTGTCAT CCAGAATGCC TTATTGTTGG 
GCTGTAGCAG TGGACAATTT AAGAAGAGAT ATACCCAATC TAAAGGGACT GGCTTCCTAC 
TATGAAATTT CAGTCGATGA CGGCCCATGG GAGAAGCAGA AGAGCTCAGG GCTCAATTTG 
TGCACTGGGA CAGGATCGAA GGCCTGGTCA TTCAATATTA ACAGGGTTGC AGCGCAGGCT 
GTTGAAGATG TTTTACATAT TGCAAGACGA CAAGGAAATC TGACTCTTCC ATTGAACAAA 
GACTTGGTAG AAAAAGTGAC AAACGAATAT AACGAATCAT TGCTCTACAG TCCAGAAGAA 
CCAAAAATAC TTTTCAGTAT TCGAGAGCCA ATAGCAAACA GAGTTTTCTC CAGCAGCCGT 
CAGCGTTGTT TCTCTTCCAA AGTTTGTGTT CGTTCTCGAT GTTGGGATGC CTGCATGGTT 
GTGGATGGAG GAACGTCTTT TGAGTTTAAC GACGGAGCAA TTGCTTCAAT GATGATCAAT 
AAAGAAGATG AGCTTCGAAC TGTGATTCTA GAGCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001078879.1
CDS	243..1601
Translation	MTCYRGFLLGSCRRVAGGRAALRGSGSGADGRRHLGHGQPRELAGGGSPADGGFRPSRVVVVAKTTRYEFEQQRYRYAELSEEDLKQLLALKGSSYSGLLERHHIHTKNVEHIIDSLRDEGIEVRLVKRREYDEETVRWADAVIAAGGDGTMLLAASKVLDRLKPVIGVNTDPERSEGHLCLPVRYTHSFPEALRRFSRGEFRWLWRQRIRLYLEGTGINPTPVDLHEQQLSLNQHSRAFNIERAHDERSEASGPQLLPVRALNEVFIGESLSSRMPYCWAVAVDNLRRDIPNLKGLASYYEISVDDGPWEKQKSSGLNLCTGTGSKAWSFNINRVAAQAVEDVLHIARRQGNLTLPLNKDLVEKVTNEYNESLLYSPEEPKILFSIREPIANRVFSSSRQRCFSSKVCVRSRCWDACMVVDGGTSFEFNDGAIASMMINKEDELRTVILEQ

Target ORF information:

RefSeq Version	NM_001085410.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus NAD kinase 2, mitochondrial (Nadk2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001085410.2

ORF Insert Sequence:

ATGACTTGCT ACCGGGGCTT CCTGCTGGGC AGCTGCCGGC GCGTGGCGGG TGGCCGCGCG 
GCTCTGCGGG GTTCGGGCTC GGGCGCGGAC GGCCGGCGGC ACTTGGGGCA CGGGCAGCCG 
CGCGAGCTGG CGGGCGGTGG TAGCCCCGCC GACGGCGGCT TCCGCCCCTC GCGGGTGGTG 
GTGGTGGCGA AAACCACCCG CTACGAGTTC GAGCAGCAGC GGTACCGCTA CGCGGAGCTC 
TCGGAGGAGG ACCTGAAGCA GCTGCTTGCA TTGAAAGGCT CGAGCTACAG TGGACTACTT 
GAGCGACATC ATATTCACAC CAAAAATGTA GAACACATAA TTGATAGTTT ACGGGATGAA 
GGGATTGAGG TTCGCCTGGT CAAGCGGAGG GAGTACGATG AAGAGACAGT TCGATGGGCA 
GACGCTGTCA TAGCTGCGGG AGGTGATGGC ACGATGCTTC TGGCTGCGAG TAAAGTCCTG 
GACAGACTTA AACCTGTCAT TGGGGTCAAC ACTGATCCGG AACGGTCTGA AGGTCACTTA 
TGTCTGCCTG TGCGATACAC GCATTCCTTC CCTGAAGCCT TACGGAGGTT CTCTCGTGGT 
GAGTTCAGGT GGTTGTGGAG GCAGCGGATC AGGTTATATC TGGAAGGGAC TGGCATAAAC 
CCCACTCCCG TGGACCTTCA CGAACAGCAG CTGAGCTTGA ATCAGCACAG CCGAGCCTTT 
AACATCGAAA GAGCGCACGA TGAAAGGTCG GAGGCGTCAG GGCCTCAGCT TCTGCCGGTG 
AGAGCGCTCA ATGAAGTCTT CATTGGGGAG AGCCTGTCAT CCAGAATGCC TTATTGTTGG 
GCTGTAGCAG TGGACAATTT AAGAAGAGAT ATACCCAATC TAAAGGGACT GGCTTCCTAC 
TATGAAATTT CAGTCGATGA CGGCCCATGG GAGAAGCAGA AGAGCTCAGG GCTCAATTTG 
TGCACTGGGA CAGGATCGAA GGCCTGGTCA TTCAATATTA ACAGGGTTGC AGCGCAGGCT 
GTTGAAGATG TTTTACATAT TGCAAGACGA CAAGGAAATC TGACTCTTCC ATTGAACAAA 
GACTTGGTAG AAAAAGTGAC AAACGAATAT AACGAATCAT TGCTCTACAG TCCAGAAGAA 
CCAAAAATAC TTTTCAGTAT TCGAGAGCCA ATAGCAAACA GAGTTTTCTC CAGCAGCCGT 
CAGCGTTGTT TCTCTTCCAA AGTTTGTGTT CGTTCTCGAT GTTGGGATGC CTGCATGGTT 
GTGGATGGAG GAACGTCTTT TGAGTTTAAC GACGGAGCAA TTGCTTCAAT GATGATCAAT 
AAAGAAGATG AGCTTCGAAC TGTGATTCTA GAGCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Nadk2 ( NM_001040395.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001035485.2 Mus musculus NAD kinase 2, mitochondrial (Nadk2), transcript variant 2, mRNA.

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CloneID	OMu17324
Clone ID Related Accession (Same CDS sequence)	NM_001040395.4
Accession Version	NM_001040395.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1293bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1571414400000
Organism	Mus musculus(house mouse)
Product	NAD kinase 2, mitochondrial isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK046666.1, AK078318.1, AK162601.1, AW537715.1, BE692075.1 and BY545448.1. On Nov 1, 2013 this sequence version replaced NM_001040395.3. Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: AK162601.1, SRR7652917.697901.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGACTTGCT ACCGGGGCTT CCTGCTGGGC AGCTGCCGGC GCGTGGCGGG TGGCCGCGCG 
GCTCTGCGGG GTTCGGGCTC GGGCGCGGAC GGCCGGCGGC ACTTGGGGCA CGGGCAGCCG 
CGCGAGCTGG CGGGCGGTGG TAGCCCCGCC GACGGCGGCT TCCGCCCCTC GCGGGTGGTG 
GTGGTGGCGA AAACCACCCG CTACGAGTTC GAGCAGCAGC GGTACCGCTA CGCGGAGCTC 
TCGGAGGAGG ACCTGAAGCA GCTGCTTGCA TTGAAAGGCT CGAGCTACAG TGGACTACTT 
GAGCGACATC ATATTCACAC CAAAAATGTA GAACACATAA TTGATAGTTT ACGGGATGAA 
GGGATTGAGG TTCGCCTGGT CAAGCGGAGG GAGTACGATG AAGAGACAGT TCGATGGGCA 
GACGCTGTCA TAGCTGCGGG AGGTGATGGC ACGATGCTTC TGGCTGCGAG TAAAGTCCTG 
GACAGACTTA AACCTGTCAT TGGGGTCAAC ACTGATCCGG AACGGTCTGA AGGTCACTTA 
TGTCTGCCTG TGCGATACAC GCATTCCTTC CCTGAAGCCT TACGGAGGTT CTCTCGTGGT 
GAGTTCAGGT GGTTGTGGAG GCAGCGGATC AGGTTATATC TGGAAGGGAC TGGCATAAAC 
CCCACTCCCG TGGACCTTCA CGAACAGCAG CTGAGCTTGA ATCAGCACAG CCGAGCCTTT 
AACATCGAAA GAGCGCACGA TGAAAGGTCG GAGGCGTCAG GGCCTCAGCT TCTGCCGGTG 
AGAGCGCTCA ATGAAGTCTT CATTGGGGAG AGCCTGTCAT CCAGGGCTTC CTACTATGAA 
ATTTCAGTCG ATGACGGCCC ATGGGAGAAG CAGAAGAGCT CAGGGCTCAA TTTGTGCACT 
GGGACAGGAT CGAAGGCCTG GTCATTCAAT ATTAACAGGG TTGCAGCGCA GGCTGTTGAA 
GATGTTTTAC ATATTGCAAG ACGACAAGGA AATCTGACTC TTCCATTGAA CAAAGACTTG 
GTAGAAAAAG TGACAAACGA ATATAACGAA TCATTGCTCT ACAGTCCAGA AGAACCAAAA 
ATACTTTTCA GTATTCGAGA GCCAATAGCA AACAGAGTTT TCTCCAGCAG CCGTCAGCGT 
TGTTTCTCTT CCAAAGTTTG TGTTCGTTCT CGATGTTGGG ATGCCTGCAT GGTTGTGGAT 
GGAGGAACGT CTTTTGAGTT TAACGACGGA GCAATTGCTT CAATGATGAT CAATAAAGAA 
GATGAGCTTC GAACTGTGAT TCTAGAGCAG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001035485.2
CDS	243..1535
Translation	MTCYRGFLLGSCRRVAGGRAALRGSGSGADGRRHLGHGQPRELAGGGSPADGGFRPSRVVVVAKTTRYEFEQQRYRYAELSEEDLKQLLALKGSSYSGLLERHHIHTKNVEHIIDSLRDEGIEVRLVKRREYDEETVRWADAVIAAGGDGTMLLAASKVLDRLKPVIGVNTDPERSEGHLCLPVRYTHSFPEALRRFSRGEFRWLWRQRIRLYLEGTGINPTPVDLHEQQLSLNQHSRAFNIERAHDERSEASGPQLLPVRALNEVFIGESLSSRASYYEISVDDGPWEKQKSSGLNLCTGTGSKAWSFNINRVAAQAVEDVLHIARRQGNLTLPLNKDLVEKVTNEYNESLLYSPEEPKILFSIREPIANRVFSSSRQRCFSSKVCVRSRCWDACMVVDGGTSFEFNDGAIASMMINKEDELRTVILEQ

Target ORF information:

RefSeq Version	NM_001040395.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus NAD kinase 2, mitochondrial (Nadk2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001040395.4

ORF Insert Sequence:

ATGACTTGCT ACCGGGGCTT CCTGCTGGGC AGCTGCCGGC GCGTGGCGGG TGGCCGCGCG 
GCTCTGCGGG GTTCGGGCTC GGGCGCGGAC GGCCGGCGGC ACTTGGGGCA CGGGCAGCCG 
CGCGAGCTGG CGGGCGGTGG TAGCCCCGCC GACGGCGGCT TCCGCCCCTC GCGGGTGGTG 
GTGGTGGCGA AAACCACCCG CTACGAGTTC GAGCAGCAGC GGTACCGCTA CGCGGAGCTC 
TCGGAGGAGG ACCTGAAGCA GCTGCTTGCA TTGAAAGGCT CGAGCTACAG TGGACTACTT 
GAGCGACATC ATATTCACAC CAAAAATGTA GAACACATAA TTGATAGTTT ACGGGATGAA 
GGGATTGAGG TTCGCCTGGT CAAGCGGAGG GAGTACGATG AAGAGACAGT TCGATGGGCA 
GACGCTGTCA TAGCTGCGGG AGGTGATGGC ACGATGCTTC TGGCTGCGAG TAAAGTCCTG 
GACAGACTTA AACCTGTCAT TGGGGTCAAC ACTGATCCGG AACGGTCTGA AGGTCACTTA 
TGTCTGCCTG TGCGATACAC GCATTCCTTC CCTGAAGCCT TACGGAGGTT CTCTCGTGGT 
GAGTTCAGGT GGTTGTGGAG GCAGCGGATC AGGTTATATC TGGAAGGGAC TGGCATAAAC 
CCCACTCCCG TGGACCTTCA CGAACAGCAG CTGAGCTTGA ATCAGCACAG CCGAGCCTTT 
AACATCGAAA GAGCGCACGA TGAAAGGTCG GAGGCGTCAG GGCCTCAGCT TCTGCCGGTG 
AGAGCGCTCA ATGAAGTCTT CATTGGGGAG AGCCTGTCAT CCAGGGCTTC CTACTATGAA 
ATTTCAGTCG ATGACGGCCC ATGGGAGAAG CAGAAGAGCT CAGGGCTCAA TTTGTGCACT 
GGGACAGGAT CGAAGGCCTG GTCATTCAAT ATTAACAGGG TTGCAGCGCA GGCTGTTGAA 
GATGTTTTAC ATATTGCAAG ACGACAAGGA AATCTGACTC TTCCATTGAA CAAAGACTTG 
GTAGAAAAAG TGACAAACGA ATATAACGAA TCATTGCTCT ACAGTCCAGA AGAACCAAAA 
ATACTTTTCA GTATTCGAGA GCCAATAGCA AACAGAGTTT TCTCCAGCAG CCGTCAGCGT 
TGTTTCTCTT CCAAAGTTTG TGTTCGTTCT CGATGTTGGG ATGCCTGCAT GGTTGTGGAT 
GGAGGAACGT CTTTTGAGTT TAACGACGGA GCAATTGCTT CAATGATGAT CAATAAAGAA 
GATGAGCTTC GAACTGTGAT TCTAGAGCAG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Placentation defects are highly prevalent in embryonic lethal mouse mutants.
Nature555(7697)463-468(2018 03)
Perez-Garcia V,Fineberg E,Wilson R,Murray A,Mazzeo CI,Tudor C,Sienerth A,White JK,Tuck E,Ryder EJ,Gleeson D,Siragher E,Wardle-Jones H,Staudt N,Wali N,Collins J,Geyer S,Busch-Nentwich EM,Galli A,Smith JC,Robertson E,Adams DJ,Weninger WJ,Mohun T,Hemberger M

Deficiency of the Mitochondrial NAD Kinase Causes Stress-Induced Hepatic Steatosis in Mice.
Gastroenterology154(1)224-237(2018 01)
Zhang K,Kim H,Fu Z,Qiu Y,Yang Z,Wang J,Zhang D,Tong X,Yin L,Li J,Wu J,Qi NR,Houten SM,Zhang R

MNADK, a novel liver-enriched mitochondrion-localized NAD kinase.
Biology open2(4)432-8(2013 Apr)
Zhang R

Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration.
Proceedings of the National Academy of Sciences of the United States of America110(6)E507-16(2013 Feb)
Lumayag S,Haldin CE,Corbett NJ,Wahlin KJ,Cowan C,Turturro S,Larsen PE,Kovacs B,Witmer PD,Valle D,Zack DJ,Nicholson DA,Xu S

Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.
Cell115(5)629-40(2003 Nov)
Mootha VK,Bunkenborg J,Olsen JV,Hjerrild M,Wisniewski JR,Stahl E,Bolouri MS,Ray HN,Sihag S,Kamal M,Patterson N,Lander ES,Mann M

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Nadk2 cDNA ORF clone, Mus musculus(house mouse)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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