Ptpmt1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ptpmt1
Entrez Gene ID	66461
Full Name	protein tyrosine phosphatase, mitochondrial 1
Synonyms	1110001D10Rik,2810004N20Rik,PLIP
General protein information	Preferred Names protein tyrosine phosphatase, mitochondrial 1 Names phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 PTEN-like phosphatase phosphoinositide lipid phosphatase
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 2 Map Location: 2\|2 E1

mRNA and Protein(s)

mRNA	Protein	Name
NM_025576.2	NP_079852.1	phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

Pathways from BioSystems

Homologies

Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000617	XP_003437045.1
Rattus norvegicus (Norway rat)	Ptpmt1	NP_001099196.1
Oryza sativa (rice)	Os01g0739200	NP_001044194.1
Homo sapiens (human)	PTPMT1	NP_783859.1
Canis lupus familiaris (dog)	PTPMT1	XP_540742.4
Mus musculus (house mouse)	Ptpmt1	NP_079852.1
Pan troglodytes (chimpanzee)	PTPMT1	XP_003313059.1
Oryza sativa (rice)	Os05g0524200	NP_001056088.1
Macaca mulatta (Rhesus monkey)	PTPMT1	XP_001105550.1
Bos taurus (cattle)	PTPMT1	NP_001069821.1
Danio rerio (zebrafish)	ptpmt1	NP_001073656.1
Gallus gallus (chicken)	PTPMT1	NP_001264811.1
Caenorhabditis elegans (roundworm)	F28C6.8	NP_001254161.1
Drosophila melanogaster (fruit fly)	Plip	NP_651180.3
Arabidopsis thaliana (thale cress)	AT5G56610	NP_200472.2

Gene Ontology
Bibliography

Related articles in PubMed

Mitochondrial oxidation of the carbohydrate fuel is required for neural precursor/stem cell function and postnatal cerebellar development.
Zheng H, Yu WM, Shen J, Kang S, Hambardzumyan D, Li JY, Shen Y, Kenney AM, Chen J, Qu CK
Science advances4(10)eaat2681(2018 10)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bućan M, Murray SA
Nature537(7621)508-514(2016 09)

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H
Nucleic acids research42(Database issue)D802-9(2014 Jan)

Metabolic regulation by the mitochondrial phosphatase PTPMT1 is required for hematopoietic stem cell differentiation.
Yu WM, Liu X, Shen J, Jovanovic O, Pohl EE, Gerson SL, Finkel T, Broxmeyer HE, Qu CK
Cell stem cell12(1)62-74(2013 Jan)

A critical role of mitochondrial phosphatase Ptpmt1 in embryogenesis reveals a mitochondrial metabolic stress-induced differentiation checkpoint in embryonic stem cells.
Shen J, Liu X, Yu WM, Liu J, Nibbelink MG, Guo C, Finkel T, Qu CK
Molecular and cellular biology31(24)4902-16(2011 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Ptpmt1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ptpmt1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu15197	NM_025576.2 Latest version!	Mus musculus protein tyrosine phosphatase, mitochondrial 1 (Ptpmt1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ptpmt1 ( NM_025576.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_079852.1 Mus musculus protein tyrosine phosphatase, mitochondrial 1 (Ptpmt1), mRNA.

Price & Availability↑

CloneID	OMu15197
Clone ID Related Accession (Same CDS sequence)	NM_025576.2
Accession Version	NM_025576.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 786bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1569772800000
Organism	Mus musculus(house mouse)
Product	phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK151972.1, AK014691.1 and AL672241.6. On Jan 5, 2007 this sequence version replaced NM_025576.1. ##Evidence-Data-START## Transcript exon combination :: AK012674.1, BC026750.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN01164131 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTCCTG TTCCGGGATC CCTCGGGCAG GGCCGGGACT CCGGGGACTC AGCTTCGAAG 
AGTCGGGAGG CATCAGGTGG CCCTCAGCTC TCGTCCTCCG CGTCCTTCTC GCGGTGGCTG 
GTCGCGAGCC CCGGGGCCGG TGGCTGGCCG CTGCGCCTGG CGGGGTGGGG CGCCTCGCCA 
CTGCGCCTGG CGGGGTGGGG CGGGATGGCG GCCTCCGCGT GGCTGGAGGC CGGCCTGGCC 
CGGGTGCTCT TCTACCCGAC GCTGCTCTAC ACAGTGTTCC GGGGGAGGGT GCGCGGCCCG 
GCGCACCGCG ACTGGTACCA CCGCATCGAC CACACGGTTC TGCTGGGCGC GCTGCCGCTG 
AAGAACATGA CGCGCCGGCT GGTACTGGAC GAGAACGTGC GCGGGGTGAT CACTATGAAC 
GAGGAGTACG AGACCCGATT CCTGTGCAAC ACCTCGAAGG AATGGAAGAA AGCAGGAGTT 
GAGCAGCTAC GGCTCAGCAC AGTCGACATG ACTGGGGTCC CAACCTTGGC CAATCTCCAC 
AAAGGAGTCC AGTTTGCTCT CAAGTACCAG GCACTGGGCC AGTGTGTCTA TGTGCATTGT 
AAGGCTGGTC GATCCAGAAG TGCCACAATG GTGGCAGCCT ATCTGATTCA GGTACACAAC 
TGGAGCCCAG AGGAGGCTAT AGAAGCGATC GCCAAAATCC GGTCACACAT CTCCATCAGG 
CCCAGCCAGC TGGAAGTTCT CAAAGAGTTC CACAAGGAGA TCACTGCAAG GGCAGCAAAG 
AATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_079852.1
CDS	65..850
Translation	MAPVPGSLGQGRDSGDSASKSREASGGPQLSSSASFSRWLVASPGAGGWPLRLAGWGASPLRLAGWGGMAASAWLEAGLARVLFYPTLLYTVFRGRVRGPAHRDWYHRIDHTVLLGALPLKNMTRRLVLDENVRGVITMNEEYETRFLCNTSKEWKKAGVEQLRLSTVDMTGVPTLANLHKGVQFALKYQALGQCVYVHCKAGRSRSATMVAAYLIQVHNWSPEEAIEAIAKIRSHISIRPSQLEVLKEFHKEITARAAKN

Target ORF information:

RefSeq Version	NM_025576.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus protein tyrosine phosphatase, mitochondrial 1 (Ptpmt1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_025576.2

ORF Insert Sequence:

ATGGCTCCTG TTCCGGGATC CCTCGGGCAG GGCCGGGACT CCGGGGACTC AGCTTCGAAG 
AGTCGGGAGG CATCAGGTGG CCCTCAGCTC TCGTCCTCCG CGTCCTTCTC GCGGTGGCTG 
GTCGCGAGCC CCGGGGCCGG TGGCTGGCCG CTGCGCCTGG CGGGGTGGGG CGCCTCGCCA 
CTGCGCCTGG CGGGGTGGGG CGGGATGGCG GCCTCCGCGT GGCTGGAGGC CGGCCTGGCC 
CGGGTGCTCT TCTACCCGAC GCTGCTCTAC ACAGTGTTCC GGGGGAGGGT GCGCGGCCCG 
GCGCACCGCG ACTGGTACCA CCGCATCGAC CACACGGTTC TGCTGGGCGC GCTGCCGCTG 
AAGAACATGA CGCGCCGGCT GGTACTGGAC GAGAACGTGC GCGGGGTGAT CACTATGAAC 
GAGGAGTACG AGACCCGATT CCTGTGCAAC ACCTCGAAGG AATGGAAGAA AGCAGGAGTT 
GAGCAGCTAC GGCTCAGCAC AGTCGACATG ACTGGGGTCC CAACCTTGGC CAATCTCCAC 
AAAGGAGTCC AGTTTGCTCT CAAGTACCAG GCACTGGGCC AGTGTGTCTA TGTGCATTGT 
AAGGCTGGTC GATCCAGAAG TGCCACAATG GTGGCAGCCT ATCTGATTCA GGTACACAAC 
TGGAGCCCAG AGGAGGCTAT AGAAGCGATC GCCAAAATCC GGTCACACAT CTCCATCAGG 
CCCAGCCAGC TGGAAGTTCT CAAAGAGTTC CACAAGGAGA TCACTGCAAG GGCAGCAAAG 
AATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mitochondrial oxidation of the carbohydrate fuel is required for neural precursor/stem cell function and postnatal cerebellar development.
Science advances4(10)eaat2681(2018 10)
Zheng H,Yu WM,Shen J,Kang S,Hambardzumyan D,Li JY,Shen Y,Kenney AM,Chen J,Qu CK

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bućan M,Murray SA

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Nucleic acids research42(Database issue)D802-9(2014 Jan)
Koscielny G,Yaikhom G,Iyer V,Meehan TF,Morgan H,Atienza-Herrero J,Blake A,Chen CK,Easty R,Di Fenza A,Fiegel T,Grifiths M,Horne A,Karp NA,Kurbatova N,Mason JC,Matthews P,Oakley DJ,Qazi A,Regnart J,Retha A,Santos LA,Sneddon DJ,Warren J,Westerberg H,Wilson RJ,Melvin DG,Smedley D,Brown SD,Flicek P,Skarnes WC,Mallon AM,Parkinson H

Metabolic regulation by the mitochondrial phosphatase PTPMT1 is required for hematopoietic stem cell differentiation.
Cell stem cell12(1)62-74(2013 Jan)
Yu WM,Liu X,Shen J,Jovanovic O,Pohl EE,Gerson SL,Finkel T,Broxmeyer HE,Qu CK

A critical role of mitochondrial phosphatase Ptpmt1 in embryogenesis reveals a mitochondrial metabolic stress-induced differentiation checkpoint in embryonic stem cells.
Molecular and cellular biology31(24)4902-16(2011 Dec)
Shen J,Liu X,Yu WM,Liu J,Nibbelink MG,Guo C,Finkel T,Qu CK

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Ptpmt1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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