Dhodh cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Dhodh
Entrez Gene ID	56749
Full Name	dihydroorotate dehydrogenase
Synonyms	2810417D19Rik,AI834883
General protein information	Preferred Names dihydroorotate dehydrogenase Names dihydroorotate dehydrogenase (quinone), mitochondrial DHOdehase dihydroorotate dehydrogenase, mitochondrial dihydroorotate oxidase
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 8 Map Location: 8\|8 D3

mRNA and Protein(s)

mRNA	Protein	Name
NM_020046.3	NP_064430.1	dihydroorotate dehydrogenase (quinone), mitochondrial precursor

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Dhodh	NP_001008553.1
Danio rerio (zebrafish)	dhodh	NP_001008608.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002037	XP_321015.5
Macaca mulatta (Rhesus monkey)	DHODH	XP_001104448.1
Kluyveromyces lactis	KLLA0C09240g	XP_452611.1
Homo sapiens (human)	DHODH	NP_001352.2
Bos taurus (cattle)	DHODH	NP_001015650.1
Caenorhabditis elegans (roundworm)	dhod-1	NP_491930.1
Oryza sativa (rice)	Os04g0676300	NP_001054255.2
Eremothecium gossypii	AGOS_ACL035C	NP_983369.1
Pan troglodytes (chimpanzee)	DHODH	XP_001171601.1
Drosophila melanogaster (fruit fly)	Dhod	NP_599138.3
Xenopus tropicalis (tropical clawed frog)	dhodh	NP_001025575.1
Canis lupus familiaris (dog)	DHODH	XP_853399.2
Mus musculus (house mouse)	Dhodh	NP_064430.1
Gallus gallus (chicken)	DHODH	NP_001006131.1
Arabidopsis thaliana (thale cress)	PYRD	NP_568428.1
Schizosaccharomyces pombe (fission yeast)	ura3	NP_593317.1

Gene Ontology
Bibliography

Related articles in PubMed

Yin Yang 1 sustains biosynthetic demands during brain development in a stage-specific manner.
Zurkirchen L, Varum S, Giger S, Klug A, Häusel J, Bossart R, Zemke M, Cantù C, Atak ZK, Zamboni N, Basler K, Sommer L
Nature communications10(1)2192(2019 05)

Placentation defects are highly prevalent in embryonic lethal mouse mutants.
Perez-Garcia V, Fineberg E, Wilson R, Murray A, Mazzeo CI, Tudor C, Sienerth A, White JK, Tuck E, Ryder EJ, Gleeson D, Siragher E, Wardle-Jones H, Staudt N, Wali N, Collins J, Geyer S, Busch-Nentwich EM, Galli A, Smith JC, Robertson E, Adams DJ, Weninger WJ, Mohun T, Hemberger M
Nature555(7697)463-468(2018 03)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bućan M, Murray SA
Nature537(7621)508-514(2016 09)

Miller (Genee-Wiedemann) syndrome represents a clinically and biochemically distinct subgroup of postaxial acrofacial dysostosis associated with partial deficiency of DHODH.
Rainger J, Bengani H, Campbell L, Anderson E, Sokhi K, Lam W, Riess A, Ansari M, Smithson S, Lees M, Mercer C, McKenzie K, Lengfeld T, Gener Querol B, Branney P, McKay S, Morrison H, Medina B, Robertson M, Kohlhase J, Gordon C, Kirk J, Wieczorek D, Fitzpatrick DR
Human molecular genetics21(18)3969-83(2012 Sep)

DHODH modulates transcriptional elongation in the neural crest and melanoma.
White RM, Cech J, Ratanasirintrawoot S, Lin CY, Rahl PB, Burke CJ, Langdon E, Tomlinson ML, Mosher J, Kaufman C, Chen F, Long HK, Kramer M, Datta S, Neuberg D, Granter S, Young RA, Morrison S, Wheeler GN, Zon LI
Nature471(7339)518-22(2011 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Dhodh gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dhodh cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu18113	NM_020046.3 Latest version!	Mus musculus dihydroorotate dehydrogenase (Dhodh), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Dhodh ( NM_020046.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_064430.1 Mus musculus dihydroorotate dehydrogenase (Dhodh), mRNA.

Price & Availability↑

CloneID	OMu18113
Clone ID Related Accession (Same CDS sequence)	NM_020046.3
Accession Version	NM_020046.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1188bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577203200000
Organism	Mus musculus(house mouse)
Product	dihydroorotate dehydrogenase (quinone), mitochondrial precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC125162.4 and BC045206.1. On Jan 24, 2006 this sequence version replaced NM_020046.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC027829.1, AF029667.2 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END##

ATGGCGTGGA GACAGCTGAG AAAGCGGGCC CTGGATGCAG CCATCATCCT TGGGGGTGGA 
GGACTTCTCT TCACCTCTTA CCTGACAGCC ACGGGGGACG ACCATTTCTA CGCCGAGTAC 
CTGATGCCGG CTCTGCAGAG ACTGCTTGAT CCAGAGTCGG CGCACCGGCT AGCTGTTCGA 
GTCATCTCCC TGGGGCTCCT TCCTCGAGCT ACGTTTCAGG ACTCCAACAT GCTGGAAGTG 
AGAGTCCTGG GCCATAAATT CCGAAATCCA GTAGGGATTG CTGCAGGATT TGACAAGCAC 
GGGGAAGCTG TGGACGGACT CTATAAGCTG GGCTTTGGTT TTGTTGAGGT GGGAAGTGTG 
ACTCCCCAGC CTCAGGAAGG AAACCCCAGG CCCCGAGTAT TCCGTCTCCC TGAGGACCAA 
GCTGTTATTA ACAGGTATGG ATTCAACAGC CACGGGCTCT CAGCGGTGGA ACACAGGCTA 
CGGGCCAGAC AGCAGAAGCA GACCCAGCTC ACCACAGATG GGCTGCCTCT GGGAATAAAC 
CTGGGGAAGA ATAAGACTTC GGTGGATGCT GCTGCAGACT ATGTAGAGGG TGTTCGCATC 
CTGGGCCCCT TGGCCGACTA CCTGGTGGTT AACGTGTCCA GTCCCAACAC TGCTGGCCTG 
AGGAGCCTAC AGGGAAAGAC TGAGCTGCGC CGCCTGCTGT CCAAGGTGCT GCAGGAGAGG 
GACGCCTTGA AGGGACCTCA GAAGCCAGCG GTGCTGGTGA AGATTGCCCC TGACCTCACG 
GCCCAGGACA AGGAGGACAT TGCCAGCGTG GCCAGAGAGC TGGGCATCGA CGGACTGATC 
ATCACAAATA CCACAGTGAG TCGCCCTGTT GGCCTCCAGG GTGCTCTGCG CTCTGAGACA 
GGGGGACTGA GTGGGAAGCC ACTCCGAGAT CTGTCGACCC AGACGATCCG GGAGATGTAC 
GCCCTCACCC AAGGCACGAT TCCCATCATC GGGGTTGGTG GTGTGAGCAG CGGACAGGAT 
GCCTTGGAGA AGATCCAGGC AGGGGCCTCC CTGGTGCAGC TGTACACGGC CCTCACCTTC 
TTGGGGCCAC CAGTCGTGGC CAGGGTCAAG CGTGAGCTGG AGGCCCTTCT AAAAGAACGG 
GGTTTTAACA CAGTGACAGA CGCCATTGGA GTAGATCACC GCAGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_064430.1
CDS	302..1489
Translation	MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR

Target ORF information:

RefSeq Version	NM_020046.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus dihydroorotate dehydrogenase (Dhodh), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020046.3

ORF Insert Sequence:

ATGGCGTGGA GACAGCTGAG AAAGCGGGCC CTGGATGCAG CCATCATCCT TGGGGGTGGA 
GGACTTCTCT TCACCTCTTA CCTGACAGCC ACGGGGGACG ACCATTTCTA CGCCGAGTAC 
CTGATGCCGG CTCTGCAGAG ACTGCTTGAT CCAGAGTCGG CGCACCGGCT AGCTGTTCGA 
GTCATCTCCC TGGGGCTCCT TCCTCGAGCT ACGTTTCAGG ACTCCAACAT GCTGGAAGTG 
AGAGTCCTGG GCCATAAATT CCGAAATCCA GTAGGGATTG CTGCAGGATT TGACAAGCAC 
GGGGAAGCTG TGGACGGACT CTATAAGCTG GGCTTTGGTT TTGTTGAGGT GGGAAGTGTG 
ACTCCCCAGC CTCAGGAAGG AAACCCCAGG CCCCGAGTAT TCCGTCTCCC TGAGGACCAA 
GCTGTTATTA ACAGGTATGG ATTCAACAGC CACGGGCTCT CAGCGGTGGA ACACAGGCTA 
CGGGCCAGAC AGCAGAAGCA GACCCAGCTC ACCACAGATG GGCTGCCTCT GGGAATAAAC 
CTGGGGAAGA ATAAGACTTC GGTGGATGCT GCTGCAGACT ATGTAGAGGG TGTTCGCATC 
CTGGGCCCCT TGGCCGACTA CCTGGTGGTT AACGTGTCCA GTCCCAACAC TGCTGGCCTG 
AGGAGCCTAC AGGGAAAGAC TGAGCTGCGC CGCCTGCTGT CCAAGGTGCT GCAGGAGAGG 
GACGCCTTGA AGGGACCTCA GAAGCCAGCG GTGCTGGTGA AGATTGCCCC TGACCTCACG 
GCCCAGGACA AGGAGGACAT TGCCAGCGTG GCCAGAGAGC TGGGCATCGA CGGACTGATC 
ATCACAAATA CCACAGTGAG TCGCCCTGTT GGCCTCCAGG GTGCTCTGCG CTCTGAGACA 
GGGGGACTGA GTGGGAAGCC ACTCCGAGAT CTGTCGACCC AGACGATCCG GGAGATGTAC 
GCCCTCACCC AAGGCACGAT TCCCATCATC GGGGTTGGTG GTGTGAGCAG CGGACAGGAT 
GCCTTGGAGA AGATCCAGGC AGGGGCCTCC CTGGTGCAGC TGTACACGGC CCTCACCTTC 
TTGGGGCCAC CAGTCGTGGC CAGGGTCAAG CGTGAGCTGG AGGCCCTTCT AAAAGAACGG 
GGTTTTAACA CAGTGACAGA CGCCATTGGA GTAGATCACC GCAGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Yin Yang 1 sustains biosynthetic demands during brain development in a stage-specific manner.
Nature communications10(1)2192(2019 05)
Zurkirchen L,Varum S,Giger S,Klug A,Häusel J,Bossart R,Zemke M,Cantù C,Atak ZK,Zamboni N,Basler K,Sommer L

Placentation defects are highly prevalent in embryonic lethal mouse mutants.
Nature555(7697)463-468(2018 03)
Perez-Garcia V,Fineberg E,Wilson R,Murray A,Mazzeo CI,Tudor C,Sienerth A,White JK,Tuck E,Ryder EJ,Gleeson D,Siragher E,Wardle-Jones H,Staudt N,Wali N,Collins J,Geyer S,Busch-Nentwich EM,Galli A,Smith JC,Robertson E,Adams DJ,Weninger WJ,Mohun T,Hemberger M

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bućan M,Murray SA

Miller (Genee-Wiedemann) syndrome represents a clinically and biochemically distinct subgroup of postaxial acrofacial dysostosis associated with partial deficiency of DHODH.
Human molecular genetics21(18)3969-83(2012 Sep)
Rainger J,Bengani H,Campbell L,Anderson E,Sokhi K,Lam W,Riess A,Ansari M,Smithson S,Lees M,Mercer C,McKenzie K,Lengfeld T,Gener Querol B,Branney P,McKay S,Morrison H,Medina B,Robertson M,Kohlhase J,Gordon C,Kirk J,Wieczorek D,Fitzpatrick DR

DHODH modulates transcriptional elongation in the neural crest and melanoma.
Nature471(7339)518-22(2011 Mar)
White RM,Cech J,Ratanasirintrawoot S,Lin CY,Rahl PB,Burke CJ,Langdon E,Tomlinson ML,Mosher J,Kaufman C,Chen F,Long HK,Kramer M,Datta S,Neuberg D,Granter S,Young RA,Morrison S,Wheeler GN,Zon LI

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Dhodh cDNA ORF clone, Mus musculus(house mouse)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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