| Gene Symbol | Hsd17b13 |
| Entrez Gene ID | 243168 |
| Full Name | hydroxysteroid (17-beta) dehydrogenase 13 |
| Synonyms | AI047820,PAN1B-like,Pan1b |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Mus musculus(house mouse) |
| Genome |
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Hsd17b13 cDNA ORF clone, Mus musculus(house mouse)
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Gene
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Clones
gRNAs
The following Hsd17b13 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hsd17b13 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OMu08833 Clone ID Related Accession (Same CDS sequence) NM_198030.2 Accession Version NM_198030.2 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 915bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1571328000000 Organism Mus musculus(house mouse) Product 17-beta-hydroxysteroid dehydrogenase 13 isoform 2 precursor Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AI573700.1, AI048624.1, DV660487.1 and AL714024.31. On Jul 22, 2009 this sequence version replaced NM_198030.1. Transcript Variant: This variant (2) uses an alternate exon at its 3' terminus, compared to variant 1, which results in a protein (isoform 2) with a longer and distinct C-terminus, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BC019427.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386, SAMN01164135 [ECO:0000348] ##Evidence-Data-END##
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901ATGAACCTCA TCCTGGAATT TCTCCTTCTG GTGGGCGTCA TCATCTACTC CTACCTGGAG
TCACTGGTAA AGTTCTTCAT TCCCCGGAGA AGGAAATCTG TGACCGGGCA GACCGTTCTC
ATCACGGGGG CCGGACACGG AATAGGCAGG CTGACTGCAT ATGAATTTGC AAAGCAGAAA
AGCAGACTGG TTCTATGGGA TATCAATAAG CGTGGTGTTG AGGAAACCGC GGACAAATGC
AGGAAACTGG GGGCCGTCGT GCACGTGTTT GTGGTGGACT GCAGCAACCG GGCCGAGATT
TACAACTCTG TGGATCAGGT AAAGAGAGAA GTAGGTGATG TCGAGATCGT GGTAAACAAC
GCCGGGGCGA TATATCCAGC AGACCTTCTT AGTGCCAAGG ACGAGGAGAT CACCAAGACC
TTTGAGGTCA ATATCCTCGG ACATTTTTGG ATCATAAAAG CACTCCTTCC ATCGATGCTG
AGAAGAAACT CTGGCCACAT TGTCACAGTG GCTTCGGTGT GCGGCCATGG AGTGATTCCT
TATCTCATCC CTTATTGCTC CAGCAAGTTT GCTGCTGTGG GCTTCCACCG AGCACTGACC
GCAGAACTGG ACACCTTGGG GAAAACCGGT ATCCAAACCT CGTGTCTCTG CCCTGTGTTC
GTGAATACTG GCTTCACCAA AAACCCGAGT ACAAGGTTAT GGCCTGTATT AGAGCCGGAA
GAAGTTGCAA GGAGTCTGAT CAATGGAATA CTTACCAACA AGAAAATGAT CTTCGTTCCA
TCCTATATCA ATATTTCTCT GATCCTGGAA AAAGGACCTG GATTCAGTTC CAAGCACCCA
CATGGTGGTT CTCAACAGCC TGTTACTCCA ATCCCAGGGG ATTTGACACC CTCTTCAGAC
TTTCTCAAAC ACTAGThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_932147.2 CDS 74..988 Translation 
Target ORF information:
RefSeq Version NM_198030.2 Organism Mus musculus(house mouse) Definition Mus musculus hydroxysteroid (17-beta) dehydrogenase 13 (Hsd17b13), transcript variant 2, mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_198030.2
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901ATGAACCTCA TCCTGGAATT TCTCCTTCTG GTGGGCGTCA TCATCTACTC CTACCTGGAG
TCACTGGTAA AGTTCTTCAT TCCCCGGAGA AGGAAATCTG TGACCGGGCA GACCGTTCTC
ATCACGGGGG CCGGACACGG AATAGGCAGG CTGACTGCAT ATGAATTTGC AAAGCAGAAA
AGCAGACTGG TTCTATGGGA TATCAATAAG CGTGGTGTTG AGGAAACCGC GGACAAATGC
AGGAAACTGG GGGCCGTCGT GCACGTGTTT GTGGTGGACT GCAGCAACCG GGCCGAGATT
TACAACTCTG TGGATCAGGT AAAGAGAGAA GTAGGTGATG TCGAGATCGT GGTAAACAAC
GCCGGGGCGA TATATCCAGC AGACCTTCTT AGTGCCAAGG ACGAGGAGAT CACCAAGACC
TTTGAGGTCA ATATCCTCGG ACATTTTTGG ATCATAAAAG CACTCCTTCC ATCGATGCTG
AGAAGAAACT CTGGCCACAT TGTCACAGTG GCTTCGGTGT GCGGCCATGG AGTGATTCCT
TATCTCATCC CTTATTGCTC CAGCAAGTTT GCTGCTGTGG GCTTCCACCG AGCACTGACC
GCAGAACTGG ACACCTTGGG GAAAACCGGT ATCCAAACCT CGTGTCTCTG CCCTGTGTTC
GTGAATACTG GCTTCACCAA AAACCCGAGT ACAAGGTTAT GGCCTGTATT AGAGCCGGAA
GAAGTTGCAA GGAGTCTGAT CAATGGAATA CTTACCAACA AGAAAATGAT CTTCGTTCCA
TCCTATATCA ATATTTCTCT GATCCTGGAA AAAGGACCTG GATTCAGTTC CAAGCACCCA
CATGGTGGTT CTCAACAGCC TGTTACTCCA ATCCCAGGGG ATTTGACACC CTCTTCAGAC
TTTCTCAAAC ACTAGThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OMu09094 Clone ID Related Accession (Same CDS sequence) NM_001163486.1 Accession Version NM_001163486.1 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 903bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1571328000000 Organism Mus musculus(house mouse) Product 17-beta-hydroxysteroid dehydrogenase 13 isoform 1 precursor Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AI573700.1, AI048624.1 and DV660487.1. Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (2). ##Evidence-Data-START## Transcript exon combination :: AY101768.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849386 [ECO:0000348] ##Evidence-Data-END##
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901ATGAACCTCA TCCTGGAATT TCTCCTTCTG GTGGGCGTCA TCATCTACTC CTACCTGGAG
TCACTGGTAA AGTTCTTCAT TCCCCGGAGA AGGAAATCTG TGACCGGGCA GACCGTTCTC
ATCACGGGGG CCGGACACGG AATAGGCAGG CTGACTGCAT ATGAATTTGC AAAGCAGAAA
AGCAGACTGG TTCTATGGGA TATCAATAAG CGTGGTGTTG AGGAAACCGC GGACAAATGC
AGGAAACTGG GGGCCGTCGT GCACGTGTTT GTGGTGGACT GCAGCAACCG GGCCGAGATT
TACAACTCTG TGGATCAGGT AAAGAGAGAA GTAGGTGATG TCGAGATCGT GGTAAACAAC
GCCGGGGCGA TATATCCAGC AGACCTTCTT AGTGCCAAGG ACGAGGAGAT CACCAAGACC
TTTGAGGTCA ATATCCTCGG ACATTTTTGG ATCATAAAAG CACTCCTTCC ATCGATGCTG
AGAAGAAACT CTGGCCACAT TGTCACAGTG GCTTCGGTGT GCGGCCATGG AGTGATTCCT
TATCTCATCC CTTATTGCTC CAGCAAGTTT GCTGCTGTGG GCTTCCACCG AGCACTGACC
GCAGAACTGG ACACCTTGGG GAAAACCGGT ATCCAAACCT CGTGTCTCTG CCCTGTGTTC
GTGAATACTG GCTTCACCAA AAACCCGAGT ACAAGGTTAT GGCCTGTATT AGAGCCGGAA
GAAGTTGCAA GGAGTCTGAT CAATGGAATA CTTACCAACA AGAAAATGAT CTTCGTTCCA
TCCTATATCA ATATTTCTCT GATCCTGGAA AAGTTTCTTC CTGAGCGTGC CTTAAAAGCG
ATCAGTCGTA TACAGAACAT TCAATTTGAA GCAATTGTGG GCCACAAAAC CAAGATGAAG
TAGThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_001156958.1 CDS 74..976 Translation
Target ORF information:
RefSeq Version NM_001163486.1 Organism Mus musculus(house mouse) Definition Mus musculus hydroxysteroid (17-beta) dehydrogenase 13 (Hsd17b13), transcript variant 1, mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK NM_001163486.1
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901ATGAACCTCA TCCTGGAATT TCTCCTTCTG GTGGGCGTCA TCATCTACTC CTACCTGGAG
TCACTGGTAA AGTTCTTCAT TCCCCGGAGA AGGAAATCTG TGACCGGGCA GACCGTTCTC
ATCACGGGGG CCGGACACGG AATAGGCAGG CTGACTGCAT ATGAATTTGC AAAGCAGAAA
AGCAGACTGG TTCTATGGGA TATCAATAAG CGTGGTGTTG AGGAAACCGC GGACAAATGC
AGGAAACTGG GGGCCGTCGT GCACGTGTTT GTGGTGGACT GCAGCAACCG GGCCGAGATT
TACAACTCTG TGGATCAGGT AAAGAGAGAA GTAGGTGATG TCGAGATCGT GGTAAACAAC
GCCGGGGCGA TATATCCAGC AGACCTTCTT AGTGCCAAGG ACGAGGAGAT CACCAAGACC
TTTGAGGTCA ATATCCTCGG ACATTTTTGG ATCATAAAAG CACTCCTTCC ATCGATGCTG
AGAAGAAACT CTGGCCACAT TGTCACAGTG GCTTCGGTGT GCGGCCATGG AGTGATTCCT
TATCTCATCC CTTATTGCTC CAGCAAGTTT GCTGCTGTGG GCTTCCACCG AGCACTGACC
GCAGAACTGG ACACCTTGGG GAAAACCGGT ATCCAAACCT CGTGTCTCTG CCCTGTGTTC
GTGAATACTG GCTTCACCAA AAACCCGAGT ACAAGGTTAT GGCCTGTATT AGAGCCGGAA
GAAGTTGCAA GGAGTCTGAT CAATGGAATA CTTACCAACA AGAAAATGAT CTTCGTTCCA
TCCTATATCA ATATTTCTCT GATCCTGGAA AAGTTTCTTC CTGAGCGTGC CTTAAAAGCG
ATCAGTCGTA TACAGAACAT TCAATTTGAA GCAATTGTGG GCCACAAAAC CAAGATGAAG
TAGThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
Hydroxysteroid (17β) dehydrogenase 13 deficiency triggers hepatic steatosis and inflammation in mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology32(6)3434-3447(2018 06)
Adam M,Heikelä H,Sobolewski C,Portius D,Mäki-Jouppila J,Mehmood A,Adhikari P,Esposito I,Elo LL,Zhang FP,Ruohonen ST,Strauss L,Foti M,Poutanen M
The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size.
Nature cell biology18(5)467-79(2016 05)
Planas-Paz L,Orsini V,Boulter L,Calabrese D,Pikiolek M,Nigsch F,Xie Y,Roma G,Donovan A,Marti P,Beckmann N,Dill MT,Carbone W,Bergling S,Isken A,Mueller M,Kinzel B,Yang Y,Mao X,Nicholson TB,Zamponi R,Capodieci P,Valdez R,Rivera D,Loew A,Ukomadu C,Terracciano LM,Bouwmeester T,Cong F,Heim MH,Forbes SJ,Ruffner H,Tchorz JS
The Angiocrine Factor Rspondin3 Is a Key Determinant of Liver Zonation.
Cell reports13(9)1757-64(2015 Dec)
Rocha AS,Vidal V,Mertz M,Kendall TJ,Charlet A,Okamoto H,Schedl A
Comparative proteomic study reveals 17β-HSD13 as a pathogenic protein in nonalcoholic fatty liver disease.
Proceedings of the National Academy of Sciences of the United States of America111(31)11437-42(2014 Aug)
Su W,Wang Y,Jia X,Wu W,Li L,Tian X,Li S,Wang C,Xu H,Cao J,Han Q,Xu S,Chen Y,Zhong Y,Zhang X,Liu P,Gustafsson JÅ,Guan Y
A mouse knockout library for secreted and transmembrane proteins.
Nature biotechnology28(7)749-55(2010 Jul)
Tang T,Li L,Tang J,Li Y,Lin WY,Martin F,Grant D,Solloway M,Parker L,Ye W,Forrest W,Ghilardi N,Oravecz T,Platt KA,Rice DS,Hansen GM,Abuin A,Eberhart DE,Godowski P,Holt KH,Peterson A,Zambrowicz BP,de Sauvage FJ
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