| Gene Symbol | Siah2 |
| Entrez Gene ID | 20439 |
| Full Name | siah E3 ubiquitin protein ligase 2 |
| Synonyms | AA415433,Sinh2 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Mus musculus(house mouse) |
| Genome |
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Siah2 cDNA ORF clone, Mus musculus(house mouse)
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Gene
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Clones
gRNAs
The following Siah2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Siah2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OMu16137 Clone ID Related Accession (Same CDS sequence) NM_009174.3 Accession Version NM_009174.3 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 978bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1570377600000 Organism Mus musculus(house mouse) Product E3 ubiquitin-protein ligase SIAH2 Comment Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC119873.38. On Nov 17, 2006 this sequence version replaced NM_009174.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC058400.1, AK149316.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164134, SAMN01164136 [ECO:0000348] ##Evidence-Data-END##
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961ATGAGCCGCC CGTCCTCCAC CGGCCCCAGC GCTAACAAAC CCTGCAGCAA GCAGCCGCCG
CCGCCTCAGA CCCCGCACGC CCCGTCCCCG GCTGCGCCCC CGGCCGCCGC CACCATCTCG
GCAGCGGGCC CCGGCTCGTC CGCGGTGCCC GCCGCGGCAG CGGTGATCTC AGGCCCCGGA
GCCGGCGGCG GGGCCGACCC GGTGTCCCCG CAGCACCACG AGCTGACCTC GCTCTTCGAG
TGCCCGGTCT GCTTTGACTA TGTCCTGCCC CCCATTCTGC AGTGCCAGGC CGGGCACCTG
GTGTGTAACC AATGCCGCCA GAAGTTAAGC TGCTGCCCGA CGTGCAGGGG CGCCCTAACG
CCCAGCATCA GGAACCTGGC TATGGAGAAG GTCGCCTCGG CAGTTCTGTT TCCCTGTAAG
TATGCTACCA CGGGCTGTTC CCTGACTCTA CACCATACAG AGAAACCAGA GCATGAAGAC
ATCTGTGAAT ACCGTCCTTA TTCCTGTCCT TGTCCTGGTG CGTCCTGCAA GTGGCAGGGA
TCCCTGGAAG CTGTGATGTC CCATCTCATG CATGCCCACA AGAGTATCAC TACCCTTCAG
GGAGAGGACA TAGTCTTTCT AGCTACAGAC ATTAACCTGC CAGGGGCTGT GGACTGGGTG
ATGATGCAGT CCTGTTTTGG CCACCACTTC ATGCTGGTAC TTGAAAAGCA AGAGAAGTAC
GAAGGCCACC AGCAGTTCTT TGCCATCGTC CTCCTCATTG GCACCCGAAA GCAAGCTGAG
AACTTTGCCT ACAGACTGGA GTTGAATGGG AACCGGAGGA GACTGACCTG GGAGGCCACA
CCTCGGTCCA TTCATGATGG CGTGGCTGCA GCCATCATGA ACAGTGACTG TCTTGTTTTT
GACACAGCCA TAGCACATCT CTTTGCAGAT AATGGGAACC TTGGAATCAA TGTCACGATA
TCTACATGCT GTCAGTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_033200.2 CDS 574..1551 Translation 
Target ORF information:
RefSeq Version NM_009174.3 Organism Mus musculus(house mouse) Definition Mus musculus siah E3 ubiquitin protein ligase 2 (Siah2), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_009174.3
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961ATGAGCCGCC CGTCCTCCAC CGGCCCCAGC GCTAACAAAC CCTGCAGCAA GCAGCCGCCG
CCGCCTCAGA CCCCGCACGC CCCGTCCCCG GCTGCGCCCC CGGCCGCCGC CACCATCTCG
GCAGCGGGCC CCGGCTCGTC CGCGGTGCCC GCCGCGGCAG CGGTGATCTC AGGCCCCGGA
GCCGGCGGCG GGGCCGACCC GGTGTCCCCG CAGCACCACG AGCTGACCTC GCTCTTCGAG
TGCCCGGTCT GCTTTGACTA TGTCCTGCCC CCCATTCTGC AGTGCCAGGC CGGGCACCTG
GTGTGTAACC AATGCCGCCA GAAGTTAAGC TGCTGCCCGA CGTGCAGGGG CGCCCTAACG
CCCAGCATCA GGAACCTGGC TATGGAGAAG GTCGCCTCGG CAGTTCTGTT TCCCTGTAAG
TATGCTACCA CGGGCTGTTC CCTGACTCTA CACCATACAG AGAAACCAGA GCATGAAGAC
ATCTGTGAAT ACCGTCCTTA TTCCTGTCCT TGTCCTGGTG CGTCCTGCAA GTGGCAGGGA
TCCCTGGAAG CTGTGATGTC CCATCTCATG CATGCCCACA AGAGTATCAC TACCCTTCAG
GGAGAGGACA TAGTCTTTCT AGCTACAGAC ATTAACCTGC CAGGGGCTGT GGACTGGGTG
ATGATGCAGT CCTGTTTTGG CCACCACTTC ATGCTGGTAC TTGAAAAGCA AGAGAAGTAC
GAAGGCCACC AGCAGTTCTT TGCCATCGTC CTCCTCATTG GCACCCGAAA GCAAGCTGAG
AACTTTGCCT ACAGACTGGA GTTGAATGGG AACCGGAGGA GACTGACCTG GGAGGCCACA
CCTCGGTCCA TTCATGATGG CGTGGCTGCA GCCATCATGA ACAGTGACTG TCTTGTTTTT
GACACAGCCA TAGCACATCT CTTTGCAGAT AATGGGAACC TTGGAATCAA TGTCACGATA
TCTACATGCT GTCAGTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
Loss of
Frontiers in physiology9558(2018)
Schiattarella GG,Boccella N,Paolillo R,Cattaneo F,Trimarco V,Franzone A,D'Apice S,Giugliano G,Rinaldi L,Borzacchiello D,Gentile A,Lombardi A,Feliciello A,Esposito G,Perrino C
E3 ubiquitin ligases SIAH1/2 regulate hypoxia-inducible factor-1 (HIF-1)-mediated Th17 cell differentiation.
International immunology29(3)133-143(2017 03)
Matsui-Hasumi A,Sato Y,Uto-Konomi A,Yamashita S,Uehori J,Yoshimura A,Yamashita M,Asahara H,Suzuki S,Kubo M
Siah2 Protein Mediates Early Events in Commitment to an Adipogenic Pathway.
The Journal of biological chemistry291(53)27289-27297(2016 12)
Kilroy G,Burk DH,Floyd ZE
Zeb1 controls neuron differentiation and germinal zone exit by a mesenchymal-epithelial-like transition.
eLife5(2016 05)
Singh S,Howell D,Trivedi N,Kessler K,Ong T,Rosmaninho P,Raposo AA,Robinson G,Roussel MF,Castro DS,Solecki DJ
Akap1 Deficiency Promotes Mitochondrial Aberrations and Exacerbates Cardiac Injury Following Permanent Coronary Ligation via Enhanced Mitophagy and Apoptosis.
PloS one11(5)e0154076(2016)
Schiattarella GG,Cattaneo F,Pironti G,Magliulo F,Carotenuto G,Pirozzi M,Polishchuk R,Borzacchiello D,Paolillo R,Oliveti M,Boccella N,Avvedimento M,Sepe M,Lombardi A,Busiello RA,Trimarco B,Esposito G,Feliciello A,Perrino C
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