Msh2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Msh2
Entrez Gene ID	17685
Full Name	mutS homolog 2
Synonyms	AI788990
General protein information	Preferred Names mutS homolog 2 Names DNA mismatch repair protein Msh2 mutS protein homolog 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 17 Map Location: 17 E4\|17 57.87 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_008628.3	NP_032654.1	DNA mismatch repair protein Msh2
NM_008628.2	NP_032654.1	DNA mismatch repair protein Msh2

Pathways from BioSystems

Homologies

Kluyveromyces lactis	KLLA0F02706g	XP_455202.1
Schizosaccharomyces pombe (fission yeast)	msh2	XP_001713136.1
Eremothecium gossypii	AGOS_AFR603C	NP_986150.1
Magnaporthe oryzae (rice blast fungus)	MGG_00879	XP_003718090.1
Rattus norvegicus (Norway rat)	Msh2	NP_112320.1
Gallus gallus (chicken)	MSH2	XP_426110.4
Saccharomyces cerevisiae (baker's yeast)	MSH2	NP_014551.1
Danio rerio (zebrafish)	msh2	NP_998689.1
Arabidopsis thaliana (thale cress)	MSH2	NP_566804.3
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010282	XP_319476.4
Homo sapiens (human)	MSH2	NP_000242.1
Canis lupus familiaris (dog)	MSH2	XP_538482.2
Bos taurus (cattle)	MSH2	NP_001029756.1
Mus musculus (house mouse)	Msh2	NP_032654.1
Drosophila melanogaster (fruit fly)	spel1	NP_001246031.1
Neurospora crassa	NCU02230	XP_959643.1
Xenopus tropicalis (tropical clawed frog)	msh2	XP_002935427.2

Gene Ontology
Bibliography

Related articles in PubMed

Quantifying Microsatellite Mutation Rates from Intestinal Stem Cell Dynamics in Msh2-Deficient Murine Epithelium.
Christopher J, Thorsen AS, Abujudeh S, Lourenço FC, Kemp R, Potter PK, Morrissey E, Hazelwood L, Winton DJ
Genetics212(3)655-665(2019 07)

DSB structure impacts DNA recombination leading to class switching and chromosomal translocations in human B cells.
So CC, Martin A
PLoS genetics15(4)e1008101(2019 04)

SAMHD1 enhances immunoglobulin hypermutation by promoting transversion mutation.
Thientosapol ES, Bosnjak D, Durack T, Stevanovski I, van Geldermalsen M, Holst J, Jahan Z, Shepard C, Weninger W, Kim B, Brink R, Jolly CJ
Proceedings of the National Academy of Sciences of the United States of America115(19)4921-4926(2018 05)

Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in CpG Dinucleotides in Mice Lacking UNG and SMUG1.
Alsøe L, Sarno A, Carracedo S, Domanska D, Dingler F, Lirussi L, SenGupta T, Tekin NB, Jobert L, Alexandrov LB, Galashevskaya A, Rada C, Sandve GK, Rognes T, Krokan HE, Nilsen H
Scientific reports7(1)7199(2017 08)

Mismatch repair deficient hematopoietic stem cells are preleukemic stem cells.
Qing Y, Gerson SL
PloS one12(8)e0182175(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Msh2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Msh2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu18389	NM_008628.3 Latest version!	Mus musculus mutS homolog 2 (Msh2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00
View Old Accession Versions >>
OMu18389	NM_008628.2	Mus musculus mutS homolog 2 (Msh2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Msh2 ( NM_008628.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032654.1 Mus musculus mutS homolog 2 (Msh2), mRNA.

Price & Availability↑

CloneID	OMu18389
Clone ID Related Accession (Same CDS sequence)	NM_008628.3 , NM_008628.2
Accession Version	NM_008628.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2808bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1574697600000
Organism	Mus musculus(house mouse)
Product	DNA mismatch repair protein Msh2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC163652.3. On Jul 13, 2018 this sequence version replaced NM_008628.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC047117.1, U21011.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGTGC AGCCTAAGGA GACGCTGCAG TTGGAAGGCG CGGCCGAGGC GGGCTTCGTG 
CGCTTCTTTG AGGGCATGCC GGAGAAGCCG AGCACCACGG TGCGCCTCTT CGACCGCGGC 
GACTTTTACA CGGCGCACGG AGAGGACGCG CTGCTGGCGG CCCGCGAGGT GTTCAAGACC 
CAGGGCGTGA TCAAGTACAT GGGGCCGGCA GGGAGTAAGA CCCTGCAGAG TGTTGTGCTT 
AGCAAGATGA ACTTTGAGTC TTTCGTGAAA GATCTTCTTC TGGTTCGCCA GTATCGAGTT 
GAAGTTTATA AGAATAAAGC TGGAAATAAG GCGTCTAAGG AGAATGAGTG GTATCTGGCA 
TTTAAGGCTT CTCCCGGCAA TCTTTCTCAG TTTGAAGACA TCCTGTTTGG TAACAATGAC 
ATGTCAGCTT CCGTTGGCGT TATGGGTATT AAAATGGCCG TGGTTGATGG TCAAAGACAT 
GTTGGAGTTG GGTATGTGGA TTCCACCCAG AGGAAGCTAG GCTTGTGTGA GTTCCCCGAG 
AATGATCAGT TCTCCAATCT CGAGGCTCTT CTGATTCAGA TTGGACCAAA GGAATGCGTT 
TTACCAGGAG GAGAGACTAC TGGAGACATG GGGAAACTGA GGCAGGTTAT CCAGAGAGGA 
GGGATTCTGA TCACAGAAAG AAAGAGAGCC GACTTTTCCA CTAAAGACAT TTATCAGGAT 
CTCAACCGGT TACTGAAAGG CAAAAAAGGA GAACAGATAA ATAGTGCTGC CCTACCAGAG 
ATGGAGAATC AGGTTGCAGT TTCATCACTA TCTGCAGTAA TCAAGTTTTT AGAACTCTTA 
TCAGACGATT CAAATTTTGG GCAGTTTGAA CTGGCCACTT TTGACTTCAG CCAGTACATG 
AAGTTGGACA TGGCAGCAGT TAGAGCCCTC AACCTTTTCC AGGGTTCTGT TGAAGACACC 
ACTGGCTCTC AGTCTCTGGC CGCATTATTG AATAAATGCA AAACTGCTCA AGGACAAAGA 
TTGGTTAACC AGTGGATCAA GCAGCCGCTC ATGGATAGGA ACAGGATAGA GGAGAGGTTA 
AATTTAGTGG AAGCTTTTGT CGAGGATTCA GAACTGAGGC AGAGTTTACA GGAGGATTTG 
CTTCGCCGGT TTCCAGACCT TAACCGGCTT GCCAAGAAAT TCCAGAGACA AGCAGCGAAT 
TTACAAGACT GTTACCGACT GTATCAGGGT ATTAACCAGC TCCCCAGCGT CATCCAGGCT 
CTGGAGAAAT ACGAAGGAAG ACACCAGGCA CTGTTGTTGG CAGTTTTTGT GACTCCTCTT 
ATTGATCTTC GTTCTGATTT TTCAAAATTT CAAGAAATGA TAGAAACAAC TTTAGATATG 
GATCAGGTGG AAAACCACGA GTTCCTTGTA AAACCTTCAT TTGATCCTAA CCTGAGTGAA 
CTAAGAGAAG TCATGGATGG CCTGGAGAAG AAGATGCAGT CCACCTTAAT AAATGCAGCC 
CGGGGGCTCG GATTGGATCC TGGCAAACAG ATTAAATTGG ACTCCAGTGC ACAGTTTGGA 
TATTATTTCC GTGTAACCTG CAAGGAAGAG AAAGTGCTTC GCAACAACAA GAACTTCAGC 
ACAGTGGACA TCCAGAAGAA TGGCGTGAAG TTTACCAACA GTGAATTGTC CTCTTTAAAT 
GAAGAATATA CTAAGAACAA AGGCGAGTAT GAAGAGGCCC AGGATGCCAT TGTTAAAGAA 
ATTGTCAATA TTTCCTCAGG CTACGTAGAG CCAATGCAGA CGCTCAACGA TGTGCTGGCT 
CACTTAGACG CCATTGTTAG CTTCGCTCAT GTGTCAAACG CAGCACCCGT TCCTTATGTA 
CGACCAGTCA TCTTGGAGAA AGGAAAAGGG AGAATTATAT TGAAAGCCTC CAGGCATGCT 
TGTGTTGAAG TTCAAGATGA AGTTGCATTT ATTCCAAATG ACGTGCACTT TGAAAAAGAT 
AAACAGATGT TCCACATCAT TACTGGTCCC AATATGGGAG GTAAATCAAC ATACATTCGT 
CAGACCGGGG TGATTGTACT CATGGCCCAA ATCGGGTGTT TTGTGCCCTG TGAGTCGGCA 
GAAGTGTCCA TTGTGGATTG CATCCTTGCT CGAGTCGGGG CTGGTGACAG TCAACTGAAA 
GGCGTCTCCA CATTCATGGC TGAAATGCTG GAGACTGCTT CCATCCTCAG GTCAGCAACC 
AAAGACTCCT TAATAATCAT TGATGAGCTG GGAAGAGGAA CCTCTACCTA TGATGGATTT 
GGGTTAGCAT GGGCTATATC AGATTACATT GCAACGAAGA TTGGTGCCTT TTGCATGTTT 
GCCACCCATT TTCATGAACT TACTGCTTTG GCCAACCAAA TACCAACTGT TAATAATCTA 
CATGTCACAG CGCTCACTAC TGAGGAGACC CTAACTATGC TTTACCAAGT GAAAAAAGGT 
GTCTGTGATC AGAGTTTCGG GATTCACGTG GCTGAGCTCG CTAACTTCCC GAGGCACGTG 
ATAGCGTGCG CCAAGCAGAA GGCTCTAGAG CTTGAAGAAT TTCAGAACAT TGGAACCTCG 
CTGGGATGTG ACGAAGCCGA GCCGGCTGCA AAGAGACGCT GCCTGGAAAG AGAGCAAGGT 
GAGAAAATTA TTCTGGAGTT CCTGTCGAAG GTCAAGCAGG TGCCCTTTAC TGCCATGTCG 
GAGGAGAGCA TCTCCGCGAA GCTGAAGCAA CTGAAAGCCG AGGTGGTCGC AAAGAACAAC 
AGCTTCGTAA ACGAGATCAT TTCACGGATA AAGGCTCCGG CTCCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032654.1
CDS	65..2872
Translation	MAVQPKETLQLEGAAEAGFVRFFEGMPEKPSTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMGPAGSKTLQSVVLSKMNFESFVKDLLLVRQYRVEVYKNKAGNKASKENEWYLAFKASPGNLSQFEDILFGNNDMSASVGVMGIKMAVVDGQRHVGVGYVDSTQRKLGLCEFPENDQFSNLEALLIQIGPKECVLPGGETTGDMGKLRQVIQRGGILITERKRADFSTKDIYQDLNRLLKGKKGEQINSAALPEMENQVAVSSLSAVIKFLELLSDDSNFGQFELATFDFSQYMKLDMAAVRALNLFQGSVEDTTGSQSLAALLNKCKTAQGQRLVNQWIKQPLMDRNRIEERLNLVEAFVEDSELRQSLQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPSVIQALEKYEGRHQALLLAVFVTPLIDLRSDFSKFQEMIETTLDMDQVENHEFLVKPSFDPNLSELREVMDGLEKKMQSTLINAARGLGLDPGKQIKLDSSAQFGYYFRVTCKEEKVLRNNKNFSTVDIQKNGVKFTNSELSSLNEEYTKNKGEYEEAQDAIVKEIVNISSGYVEPMQTLNDVLAHLDAIVSFAHVSNAAPVPYVRPVILEKGKGRIILKASRHACVEVQDEVAFIPNDVHFEKDKQMFHIITGPNMGGKSTYIRQTGVIVLMAQIGCFVPCESAEVSIVDCILARVGAGDSQLKGVSTFMAEMLETASILRSATKDSLIIIDELGRGTSTYDGFGLAWAISDYIATKIGAFCMFATHFHELTALANQIPTVNNLHVTALTTEETLTMLYQVKKGVCDQSFGIHVAELANFPRHVIACAKQKALELEEFQNIGTSLGCDEAEPAAKRRCLEREQGEKIILEFLSKVKQVPFTAMSEESISAKLKQLKAEVVAKNNSFVNEIISRIKAPAP

Target ORF information:

RefSeq Version	NM_008628.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus mutS homolog 2 (Msh2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008628.3

ORF Insert Sequence:

ATGGCGGTGC AGCCTAAGGA GACGCTGCAG TTGGAAGGCG CGGCCGAGGC GGGCTTCGTG 
CGCTTCTTTG AGGGCATGCC GGAGAAGCCG AGCACCACGG TGCGCCTCTT CGACCGCGGC 
GACTTTTACA CGGCGCACGG AGAGGACGCG CTGCTGGCGG CCCGCGAGGT GTTCAAGACC 
CAGGGCGTGA TCAAGTACAT GGGGCCGGCA GGGAGTAAGA CCCTGCAGAG TGTTGTGCTT 
AGCAAGATGA ACTTTGAGTC TTTCGTGAAA GATCTTCTTC TGGTTCGCCA GTATCGAGTT 
GAAGTTTATA AGAATAAAGC TGGAAATAAG GCGTCTAAGG AGAATGAGTG GTATCTGGCA 
TTTAAGGCTT CTCCCGGCAA TCTTTCTCAG TTTGAAGACA TCCTGTTTGG TAACAATGAC 
ATGTCAGCTT CCGTTGGCGT TATGGGTATT AAAATGGCCG TGGTTGATGG TCAAAGACAT 
GTTGGAGTTG GGTATGTGGA TTCCACCCAG AGGAAGCTAG GCTTGTGTGA GTTCCCCGAG 
AATGATCAGT TCTCCAATCT CGAGGCTCTT CTGATTCAGA TTGGACCAAA GGAATGCGTT 
TTACCAGGAG GAGAGACTAC TGGAGACATG GGGAAACTGA GGCAGGTTAT CCAGAGAGGA 
GGGATTCTGA TCACAGAAAG AAAGAGAGCC GACTTTTCCA CTAAAGACAT TTATCAGGAT 
CTCAACCGGT TACTGAAAGG CAAAAAAGGA GAACAGATAA ATAGTGCTGC CCTACCAGAG 
ATGGAGAATC AGGTTGCAGT TTCATCACTA TCTGCAGTAA TCAAGTTTTT AGAACTCTTA 
TCAGACGATT CAAATTTTGG GCAGTTTGAA CTGGCCACTT TTGACTTCAG CCAGTACATG 
AAGTTGGACA TGGCAGCAGT TAGAGCCCTC AACCTTTTCC AGGGTTCTGT TGAAGACACC 
ACTGGCTCTC AGTCTCTGGC CGCATTATTG AATAAATGCA AAACTGCTCA AGGACAAAGA 
TTGGTTAACC AGTGGATCAA GCAGCCGCTC ATGGATAGGA ACAGGATAGA GGAGAGGTTA 
AATTTAGTGG AAGCTTTTGT CGAGGATTCA GAACTGAGGC AGAGTTTACA GGAGGATTTG 
CTTCGCCGGT TTCCAGACCT TAACCGGCTT GCCAAGAAAT TCCAGAGACA AGCAGCGAAT 
TTACAAGACT GTTACCGACT GTATCAGGGT ATTAACCAGC TCCCCAGCGT CATCCAGGCT 
CTGGAGAAAT ACGAAGGAAG ACACCAGGCA CTGTTGTTGG CAGTTTTTGT GACTCCTCTT 
ATTGATCTTC GTTCTGATTT TTCAAAATTT CAAGAAATGA TAGAAACAAC TTTAGATATG 
GATCAGGTGG AAAACCACGA GTTCCTTGTA AAACCTTCAT TTGATCCTAA CCTGAGTGAA 
CTAAGAGAAG TCATGGATGG CCTGGAGAAG AAGATGCAGT CCACCTTAAT AAATGCAGCC 
CGGGGGCTCG GATTGGATCC TGGCAAACAG ATTAAATTGG ACTCCAGTGC ACAGTTTGGA 
TATTATTTCC GTGTAACCTG CAAGGAAGAG AAAGTGCTTC GCAACAACAA GAACTTCAGC 
ACAGTGGACA TCCAGAAGAA TGGCGTGAAG TTTACCAACA GTGAATTGTC CTCTTTAAAT 
GAAGAATATA CTAAGAACAA AGGCGAGTAT GAAGAGGCCC AGGATGCCAT TGTTAAAGAA 
ATTGTCAATA TTTCCTCAGG CTACGTAGAG CCAATGCAGA CGCTCAACGA TGTGCTGGCT 
CACTTAGACG CCATTGTTAG CTTCGCTCAT GTGTCAAACG CAGCACCCGT TCCTTATGTA 
CGACCAGTCA TCTTGGAGAA AGGAAAAGGG AGAATTATAT TGAAAGCCTC CAGGCATGCT 
TGTGTTGAAG TTCAAGATGA AGTTGCATTT ATTCCAAATG ACGTGCACTT TGAAAAAGAT 
AAACAGATGT TCCACATCAT TACTGGTCCC AATATGGGAG GTAAATCAAC ATACATTCGT 
CAGACCGGGG TGATTGTACT CATGGCCCAA ATCGGGTGTT TTGTGCCCTG TGAGTCGGCA 
GAAGTGTCCA TTGTGGATTG CATCCTTGCT CGAGTCGGGG CTGGTGACAG TCAACTGAAA 
GGCGTCTCCA CATTCATGGC TGAAATGCTG GAGACTGCTT CCATCCTCAG GTCAGCAACC 
AAAGACTCCT TAATAATCAT TGATGAGCTG GGAAGAGGAA CCTCTACCTA TGATGGATTT 
GGGTTAGCAT GGGCTATATC AGATTACATT GCAACGAAGA TTGGTGCCTT TTGCATGTTT 
GCCACCCATT TTCATGAACT TACTGCTTTG GCCAACCAAA TACCAACTGT TAATAATCTA 
CATGTCACAG CGCTCACTAC TGAGGAGACC CTAACTATGC TTTACCAAGT GAAAAAAGGT 
GTCTGTGATC AGAGTTTCGG GATTCACGTG GCTGAGCTCG CTAACTTCCC GAGGCACGTG 
ATAGCGTGCG CCAAGCAGAA GGCTCTAGAG CTTGAAGAAT TTCAGAACAT TGGAACCTCG 
CTGGGATGTG ACGAAGCCGA GCCGGCTGCA AAGAGACGCT GCCTGGAAAG AGAGCAAGGT 
GAGAAAATTA TTCTGGAGTT CCTGTCGAAG GTCAAGCAGG TGCCCTTTAC TGCCATGTCG 
GAGGAGAGCA TCTCCGCGAA GCTGAAGCAA CTGAAAGCCG AGGTGGTCGC AAAGAACAAC 
AGCTTCGTAA ACGAGATCAT TTCACGGATA AAGGCTCCGG CTCCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Msh2 ( NM_008628.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032654.1 Mus musculus mutS homolog 2 (Msh2), mRNA.

Price & Availability↑

CloneID	OMu18389
Clone ID Related Accession (Same CDS sequence)	NM_008628.3 , NM_008628.2
Accession Version	NM_008628.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2808bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1512748800000
Organism	Mus musculus(house mouse)
Product	DNA mismatch repair protein Msh2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC163652.3. On Nov 17, 2006 this sequence version replaced NM_008628.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC047117.1, AK157842.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849380 [ECO:0000348] ##Evidence-Data-END##

ATGGCGGTGC AGCCTAAGGA GACGCTGCAG TTGGAAGGCG CGGCCGAGGC GGGCTTCGTG 
CGCTTCTTTG AGGGCATGCC GGAGAAGCCG AGCACCACGG TGCGCCTCTT CGACCGCGGC 
GACTTTTACA CGGCGCACGG AGAGGACGCG CTGCTGGCGG CCCGCGAGGT GTTCAAGACC 
CAGGGCGTGA TCAAGTACAT GGGGCCGGCA GGGAGTAAGA CCCTGCAGAG TGTTGTGCTT 
AGCAAGATGA ACTTTGAGTC TTTCGTGAAA GATCTTCTTC TGGTTCGCCA GTATCGAGTT 
GAAGTTTATA AGAATAAAGC TGGAAATAAG GCGTCTAAGG AGAATGAGTG GTATCTGGCA 
TTTAAGGCTT CTCCCGGCAA TCTTTCTCAG TTTGAAGACA TCCTGTTTGG TAACAATGAC 
ATGTCAGCTT CCGTTGGCGT TATGGGTATT AAAATGGCCG TGGTTGATGG TCAAAGACAT 
GTTGGAGTTG GGTATGTGGA TTCCACCCAG AGGAAGCTAG GCTTGTGTGA GTTCCCCGAG 
AATGATCAGT TCTCCAATCT CGAGGCTCTT CTGATTCAGA TTGGACCAAA GGAATGCGTT 
TTACCAGGAG GAGAGACTAC TGGAGACATG GGGAAACTGA GGCAGGTTAT CCAGAGAGGA 
GGGATTCTGA TCACAGAAAG AAAGAGAGCC GACTTTTCCA CTAAAGACAT TTATCAGGAT 
CTCAACCGGT TACTGAAAGG CAAAAAAGGA GAACAGATAA ATAGTGCTGC CCTACCAGAG 
ATGGAGAATC AGGTTGCAGT TTCATCACTA TCTGCAGTAA TCAAGTTTTT AGAACTCTTA 
TCAGACGATT CAAATTTTGG GCAGTTTGAA CTGGCCACTT TTGACTTCAG CCAGTACATG 
AAGTTGGACA TGGCAGCAGT TAGAGCCCTC AACCTTTTCC AGGGTTCTGT TGAAGACACC 
ACTGGCTCTC AGTCTCTGGC CGCATTATTG AATAAATGCA AAACTGCTCA AGGACAAAGA 
TTGGTTAACC AGTGGATCAA GCAGCCGCTC ATGGATAGGA ACAGGATAGA GGAGAGGTTA 
AATTTAGTGG AAGCTTTTGT CGAGGATTCA GAACTGAGGC AGAGTTTACA GGAGGATTTG 
CTTCGCCGGT TTCCAGACCT TAACCGGCTT GCCAAGAAAT TCCAGAGACA AGCAGCGAAT 
TTACAAGACT GTTACCGACT GTATCAGGGT ATTAACCAGC TCCCCAGCGT CATCCAGGCT 
CTGGAGAAAT ACGAAGGAAG ACACCAGGCA CTGTTGTTGG CAGTTTTTGT GACTCCTCTT 
ATTGATCTTC GTTCTGATTT TTCAAAATTT CAAGAAATGA TAGAAACAAC TTTAGATATG 
GATCAGGTGG AAAACCACGA GTTCCTTGTA AAACCTTCAT TTGATCCTAA CCTGAGTGAA 
CTAAGAGAAG TCATGGATGG CCTGGAGAAG AAGATGCAGT CCACCTTAAT AAATGCAGCC 
CGGGGGCTCG GATTGGATCC TGGCAAACAG ATTAAATTGG ACTCCAGTGC ACAGTTTGGA 
TATTATTTCC GTGTAACCTG CAAGGAAGAG AAAGTGCTTC GCAACAACAA GAACTTCAGC 
ACAGTGGACA TCCAGAAGAA TGGCGTGAAG TTTACCAACA GTGAATTGTC CTCTTTAAAT 
GAAGAATATA CTAAGAACAA AGGCGAGTAT GAAGAGGCCC AGGATGCCAT TGTTAAAGAA 
ATTGTCAATA TTTCCTCAGG CTACGTAGAG CCAATGCAGA CGCTCAACGA TGTGCTGGCT 
CACTTAGACG CCATTGTTAG CTTCGCTCAT GTGTCAAACG CAGCACCCGT TCCTTATGTA 
CGACCAGTCA TCTTGGAGAA AGGAAAAGGG AGAATTATAT TGAAAGCCTC CAGGCATGCT 
TGTGTTGAAG TTCAAGATGA AGTTGCATTT ATTCCAAATG ACGTGCACTT TGAAAAAGAT 
AAACAGATGT TCCACATCAT TACTGGTCCC AATATGGGAG GTAAATCAAC ATACATTCGT 
CAGACCGGGG TGATTGTACT CATGGCCCAA ATCGGGTGTT TTGTGCCCTG TGAGTCGGCA 
GAAGTGTCCA TTGTGGATTG CATCCTTGCT CGAGTCGGGG CTGGTGACAG TCAACTGAAA 
GGCGTCTCCA CATTCATGGC TGAAATGCTG GAGACTGCTT CCATCCTCAG GTCAGCAACC 
AAAGACTCCT TAATAATCAT TGATGAGCTG GGAAGAGGAA CCTCTACCTA TGATGGATTT 
GGGTTAGCAT GGGCTATATC AGATTACATT GCAACGAAGA TTGGTGCCTT TTGCATGTTT 
GCCACCCATT TTCATGAACT TACTGCTTTG GCCAACCAAA TACCAACTGT TAATAATCTA 
CATGTCACAG CGCTCACTAC TGAGGAGACC CTAACTATGC TTTACCAAGT GAAAAAAGGT 
GTCTGTGATC AGAGTTTCGG GATTCACGTG GCTGAGCTCG CTAACTTCCC GAGGCACGTG 
ATAGCGTGCG CCAAGCAGAA GGCTCTAGAG CTTGAAGAAT TTCAGAACAT TGGAACCTCG 
CTGGGATGTG ACGAAGCCGA GCCGGCTGCA AAGAGACGCT GCCTGGAAAG AGAGCAAGGT 
GAGAAAATTA TTCTGGAGTT CCTGTCGAAG GTCAAGCAGG TGCCCTTTAC TGCCATGTCG 
GAGGAGAGCA TCTCCGCGAA GCTGAAGCAA CTGAAAGCCG AGGTGGTCGC AAAGAACAAC 
AGCTTCGTAA ACGAGATCAT TTCACGGATA AAGGCTCCGG CTCCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032654.1
CDS	40..2847
Translation	MAVQPKETLQLEGAAEAGFVRFFEGMPEKPSTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMGPAGSKTLQSVVLSKMNFESFVKDLLLVRQYRVEVYKNKAGNKASKENEWYLAFKASPGNLSQFEDILFGNNDMSASVGVMGIKMAVVDGQRHVGVGYVDSTQRKLGLCEFPENDQFSNLEALLIQIGPKECVLPGGETTGDMGKLRQVIQRGGILITERKRADFSTKDIYQDLNRLLKGKKGEQINSAALPEMENQVAVSSLSAVIKFLELLSDDSNFGQFELATFDFSQYMKLDMAAVRALNLFQGSVEDTTGSQSLAALLNKCKTAQGQRLVNQWIKQPLMDRNRIEERLNLVEAFVEDSELRQSLQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPSVIQALEKYEGRHQALLLAVFVTPLIDLRSDFSKFQEMIETTLDMDQVENHEFLVKPSFDPNLSELREVMDGLEKKMQSTLINAARGLGLDPGKQIKLDSSAQFGYYFRVTCKEEKVLRNNKNFSTVDIQKNGVKFTNSELSSLNEEYTKNKGEYEEAQDAIVKEIVNISSGYVEPMQTLNDVLAHLDAIVSFAHVSNAAPVPYVRPVILEKGKGRIILKASRHACVEVQDEVAFIPNDVHFEKDKQMFHIITGPNMGGKSTYIRQTGVIVLMAQIGCFVPCESAEVSIVDCILARVGAGDSQLKGVSTFMAEMLETASILRSATKDSLIIIDELGRGTSTYDGFGLAWAISDYIATKIGAFCMFATHFHELTALANQIPTVNNLHVTALTTEETLTMLYQVKKGVCDQSFGIHVAELANFPRHVIACAKQKALELEEFQNIGTSLGCDEAEPAAKRRCLEREQGEKIILEFLSKVKQVPFTAMSEESISAKLKQLKAEVVAKNNSFVNEIISRIKAPAP

Target ORF information:

RefSeq Version	NM_008628.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus mutS homolog 2 (Msh2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008628.2

ORF Insert Sequence:

ATGGCGGTGC AGCCTAAGGA GACGCTGCAG TTGGAAGGCG CGGCCGAGGC GGGCTTCGTG 
CGCTTCTTTG AGGGCATGCC GGAGAAGCCG AGCACCACGG TGCGCCTCTT CGACCGCGGC 
GACTTTTACA CGGCGCACGG AGAGGACGCG CTGCTGGCGG CCCGCGAGGT GTTCAAGACC 
CAGGGCGTGA TCAAGTACAT GGGGCCGGCA GGGAGTAAGA CCCTGCAGAG TGTTGTGCTT 
AGCAAGATGA ACTTTGAGTC TTTCGTGAAA GATCTTCTTC TGGTTCGCCA GTATCGAGTT 
GAAGTTTATA AGAATAAAGC TGGAAATAAG GCGTCTAAGG AGAATGAGTG GTATCTGGCA 
TTTAAGGCTT CTCCCGGCAA TCTTTCTCAG TTTGAAGACA TCCTGTTTGG TAACAATGAC 
ATGTCAGCTT CCGTTGGCGT TATGGGTATT AAAATGGCCG TGGTTGATGG TCAAAGACAT 
GTTGGAGTTG GGTATGTGGA TTCCACCCAG AGGAAGCTAG GCTTGTGTGA GTTCCCCGAG 
AATGATCAGT TCTCCAATCT CGAGGCTCTT CTGATTCAGA TTGGACCAAA GGAATGCGTT 
TTACCAGGAG GAGAGACTAC TGGAGACATG GGGAAACTGA GGCAGGTTAT CCAGAGAGGA 
GGGATTCTGA TCACAGAAAG AAAGAGAGCC GACTTTTCCA CTAAAGACAT TTATCAGGAT 
CTCAACCGGT TACTGAAAGG CAAAAAAGGA GAACAGATAA ATAGTGCTGC CCTACCAGAG 
ATGGAGAATC AGGTTGCAGT TTCATCACTA TCTGCAGTAA TCAAGTTTTT AGAACTCTTA 
TCAGACGATT CAAATTTTGG GCAGTTTGAA CTGGCCACTT TTGACTTCAG CCAGTACATG 
AAGTTGGACA TGGCAGCAGT TAGAGCCCTC AACCTTTTCC AGGGTTCTGT TGAAGACACC 
ACTGGCTCTC AGTCTCTGGC CGCATTATTG AATAAATGCA AAACTGCTCA AGGACAAAGA 
TTGGTTAACC AGTGGATCAA GCAGCCGCTC ATGGATAGGA ACAGGATAGA GGAGAGGTTA 
AATTTAGTGG AAGCTTTTGT CGAGGATTCA GAACTGAGGC AGAGTTTACA GGAGGATTTG 
CTTCGCCGGT TTCCAGACCT TAACCGGCTT GCCAAGAAAT TCCAGAGACA AGCAGCGAAT 
TTACAAGACT GTTACCGACT GTATCAGGGT ATTAACCAGC TCCCCAGCGT CATCCAGGCT 
CTGGAGAAAT ACGAAGGAAG ACACCAGGCA CTGTTGTTGG CAGTTTTTGT GACTCCTCTT 
ATTGATCTTC GTTCTGATTT TTCAAAATTT CAAGAAATGA TAGAAACAAC TTTAGATATG 
GATCAGGTGG AAAACCACGA GTTCCTTGTA AAACCTTCAT TTGATCCTAA CCTGAGTGAA 
CTAAGAGAAG TCATGGATGG CCTGGAGAAG AAGATGCAGT CCACCTTAAT AAATGCAGCC 
CGGGGGCTCG GATTGGATCC TGGCAAACAG ATTAAATTGG ACTCCAGTGC ACAGTTTGGA 
TATTATTTCC GTGTAACCTG CAAGGAAGAG AAAGTGCTTC GCAACAACAA GAACTTCAGC 
ACAGTGGACA TCCAGAAGAA TGGCGTGAAG TTTACCAACA GTGAATTGTC CTCTTTAAAT 
GAAGAATATA CTAAGAACAA AGGCGAGTAT GAAGAGGCCC AGGATGCCAT TGTTAAAGAA 
ATTGTCAATA TTTCCTCAGG CTACGTAGAG CCAATGCAGA CGCTCAACGA TGTGCTGGCT 
CACTTAGACG CCATTGTTAG CTTCGCTCAT GTGTCAAACG CAGCACCCGT TCCTTATGTA 
CGACCAGTCA TCTTGGAGAA AGGAAAAGGG AGAATTATAT TGAAAGCCTC CAGGCATGCT 
TGTGTTGAAG TTCAAGATGA AGTTGCATTT ATTCCAAATG ACGTGCACTT TGAAAAAGAT 
AAACAGATGT TCCACATCAT TACTGGTCCC AATATGGGAG GTAAATCAAC ATACATTCGT 
CAGACCGGGG TGATTGTACT CATGGCCCAA ATCGGGTGTT TTGTGCCCTG TGAGTCGGCA 
GAAGTGTCCA TTGTGGATTG CATCCTTGCT CGAGTCGGGG CTGGTGACAG TCAACTGAAA 
GGCGTCTCCA CATTCATGGC TGAAATGCTG GAGACTGCTT CCATCCTCAG GTCAGCAACC 
AAAGACTCCT TAATAATCAT TGATGAGCTG GGAAGAGGAA CCTCTACCTA TGATGGATTT 
GGGTTAGCAT GGGCTATATC AGATTACATT GCAACGAAGA TTGGTGCCTT TTGCATGTTT 
GCCACCCATT TTCATGAACT TACTGCTTTG GCCAACCAAA TACCAACTGT TAATAATCTA 
CATGTCACAG CGCTCACTAC TGAGGAGACC CTAACTATGC TTTACCAAGT GAAAAAAGGT 
GTCTGTGATC AGAGTTTCGG GATTCACGTG GCTGAGCTCG CTAACTTCCC GAGGCACGTG 
ATAGCGTGCG CCAAGCAGAA GGCTCTAGAG CTTGAAGAAT TTCAGAACAT TGGAACCTCG 
CTGGGATGTG ACGAAGCCGA GCCGGCTGCA AAGAGACGCT GCCTGGAAAG AGAGCAAGGT 
GAGAAAATTA TTCTGGAGTT CCTGTCGAAG GTCAAGCAGG TGCCCTTTAC TGCCATGTCG 
GAGGAGAGCA TCTCCGCGAA GCTGAAGCAA CTGAAAGCCG AGGTGGTCGC AAAGAACAAC 
AGCTTCGTAA ACGAGATCAT TTCACGGATA AAGGCTCCGG CTCCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Quantifying Microsatellite Mutation Rates from Intestinal Stem Cell Dynamics in Msh2-Deficient Murine Epithelium.
Genetics212(3)655-665(2019 07)
Christopher J,Thorsen AS,Abujudeh S,Lourenço FC,Kemp R,Potter PK,Morrissey E,Hazelwood L,Winton DJ

DSB structure impacts DNA recombination leading to class switching and chromosomal translocations in human B cells.
PLoS genetics15(4)e1008101(2019 04)
So CC,Martin A

SAMHD1 enhances immunoglobulin hypermutation by promoting transversion mutation.
Proceedings of the National Academy of Sciences of the United States of America115(19)4921-4926(2018 05)
Thientosapol ES,Bosnjak D,Durack T,Stevanovski I,van Geldermalsen M,Holst J,Jahan Z,Shepard C,Weninger W,Kim B,Brink R,Jolly CJ

Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in CpG Dinucleotides in Mice Lacking UNG and SMUG1.
Scientific reports7(1)7199(2017 08)
Alsøe L,Sarno A,Carracedo S,Domanska D,Dingler F,Lirussi L,SenGupta T,Tekin NB,Jobert L,Alexandrov LB,Galashevskaya A,Rada C,Sandve GK,Rognes T,Krokan HE,Nilsen H

Mismatch repair deficient hematopoietic stem cells are preleukemic stem cells.
PloS one12(8)e0182175(2017)
Qing Y,Gerson SL

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Msh2 cDNA ORF clone, Mus musculus(house mouse)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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