Kpnb1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Kpnb1
Entrez Gene ID	16211
Full Name	karyopherin (importin) beta 1
Synonyms	AA409963,IPOB,Impnb
General protein information	Preferred Names karyopherin (importin) beta 1 Names importin subunit beta-1 PTAC97 SCG importin beta karyopherin subunit beta-1 nuclear factor p97 pore targeting complex 97 kDa subunit
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 11 Map Location: 11\|11 D

mRNA and Protein(s)

mRNA	Protein	Name
NM_008379.3	NP_032405.3	importin subunit beta-1

Pathways from BioSystems

Homologies

Kluyveromyces lactis	KLLA0B05665g	XP_451788.1
Gallus gallus (chicken)	KPNB1	XP_004950071.1
Caenorhabditis elegans (roundworm)	imb-1	NP_491477.2
Homo sapiens (human)	KPNB1	NP_002256.2
Bos taurus (cattle)	KPNB1	NP_001180082.1
Mus musculus (house mouse)	Kpnb1	NP_032405.3
Drosophila melanogaster (fruit fly)	Fs(2)Ket	NP_001246109.1
Oryza sativa (rice)	Os12g0568800	NP_001067068.1
Neurospora crassa	NCU02011	XP_964876.1
Schizosaccharomyces pombe (fission yeast)	kap95	NP_594233.1
Saccharomyces cerevisiae (baker's yeast)	KAP95	NP_013451.1
Pan troglodytes (chimpanzee)	KPNB1	XP_003315429.1
Arabidopsis thaliana (thale cress)	AT5G53480	NP_200160.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009921	XP_319040.3
Xenopus tropicalis (tropical clawed frog)	kpnb1	XP_002940197.1
Magnaporthe oryzae (rice blast fungus)	MGG_03668	XP_003716218.1
Macaca mulatta (Rhesus monkey)	KPNB1	XP_001082833.2
Canis lupus familiaris (dog)	KPNB1	XP_005624657.1
Rattus norvegicus (Norway rat)	Kpnb1	NP_058759.1
Danio rerio (zebrafish)	kpnb1	NP_001032791.2
Eremothecium gossypii	AGOS_ACL187W	NP_983217.2

Gene Ontology
Bibliography

Related articles in PubMed

Reactive oxygen species regulate axonal regeneration through the release of exosomal NADPH oxidase 2 complexes into injured axons.
Hervera A, De Virgiliis F, Palmisano I, Zhou L, Tantardini E, Kong G, Hutson T, Danzi MC, Perry RB, Santos CXC, Kapustin AN, Fleck RA, Del Río JA, Carroll T, Lemmon V, Bixby JL, Shah AM, Fainzilber M, Di Giovanni S
Nature cell biology20(3)307-319(2018 03)

AMP Kinase Activation Alters Oxidant-Induced Stress Granule Assembly by Modulating Cell Signaling and Microtubule Organization.
Mahboubi H, Koromilas AE, Stochaj U
Molecular pharmacology90(4)460-8(2016 10)

Nucleolin-Mediated RNA Localization Regulates Neuron Growth and Cycling Cell Size.
Perry RB, Rishal I, Doron-Mandel E, Kalinski AL, Medzihradszky KF, Terenzio M, Alber S, Koley S, Lin A, Rozenbaum M, Yudin D, Sahoo PK, Gomes C, Shinder V, Geraisy W, Huebner EA, Woolf CJ, Yaron A, Burlingame AL, Twiss JL, Fainzilber M
Cell reports16(6)1664-1676(2016 08)

The importin protein karyopherin-β1 regulates the mice fibroblast-like synoviocytes inflammation via facilitating nucleus transportation of STAT3 transcription factor.
Sun C, Yu Z, Wang Y, Tao T
Biochemical and biophysical research communications471(4)553-9(2016 Mar)

KPNβ1 promotes palmitate-induced insulin resistance via NF-κB signaling in hepatocytes.
Wang S, Zhao Y, Xia N, Zhang W, Tang Z, Wang C, Zhu X, Cui S
Journal of physiology and biochemistry71(4)763-72(2015 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Kpnb1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Kpnb1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu01812	NM_008379.3 Latest version!	Mus musculus karyopherin (importin) beta 1 (Kpnb1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$517.30 $739.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Kpnb1 ( NM_008379.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032405.3 Mus musculus karyopherin (importin) beta 1 (Kpnb1), mRNA.

Price & Availability↑

CloneID	OMu01812
Clone ID Related Accession (Same CDS sequence)	NM_008379.3
Accession Version	NM_008379.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2631bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577203200000
Organism	Mus musculus(house mouse)
Product	importin subunit beta-1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK147175.1, BC052438.1 and AL627445.21. On Feb 17, 2006 this sequence version replaced NM_008379.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK147175.1, AK077709.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164137, SAMN01164139 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCTCA TAACCATCCT CGAGAAGACC GTGTCTCCGG ATCGGCTGGA GCTGGAAGCG 
GCGCAGAAGT TCCTCGAGCG TGCGGCCGTG GAGAATCTGC CCACGTTCCT TGTGGAACTG 
TCCAGAGTGC TGGCAAACCC AGGAAACAGT CAGGTTGCCA GAGTTGCAGC TGGTCTACAA 
ATTAAGAACT CTTTGACATC GAAAGATCCA GATATCAAGG CACAATACCA GCAGAGGTGG 
CTCGCTATTG ATGCTAATGC TCGACGGGAA GTCAAGAACT ATGTTTTGCA GACGTTGGGC 
ACAGAAACGT ACCGGCCTAG TTCGGCCTCA CAGTGTGTGG CTGGTATTGC TTGTGCAGAG 
ATCCCAGTAA GCCAGTGGCC AGAGCTAATT CCTCAGCTGG TAGCCAATGT CACAAACCCC 
AACAGCACAG AGCATATGAA AGAGTCCACA TTGGAAGCTA TTGGTTACAT TTGCCAAGAT 
ATAGACCCAG AGCAGCTACA GGATAAGTCC AATGAGATCC TGACTGCCAT AATCCAGGGG 
ATGAGGAAGG AGGAGCCTAG TAACAATGTG AAGCTGGCTG CTACCAATGC ACTCCTGAAC 
TCACTAGAGT TCACCAAAGC AAACTTTGAC AAAGAGTCTG AAAGGCACTT TATCATGCAA 
GTGGTCTGTG AAGCCACACA GTGTCCAGAC ACAAGGGTAA GAGTGGCTGC TTTACAGAAT 
CTAGTGAAGA TAATGTCCTT GTATTACCAG TACATGGAGA CATACATGGG TCCTGCCCTT 
TTTGCAATCA CAATTGAAGC AATGAAAAGT GACATTGATG AGGTGGCTCT CCAAGGGATA 
GAGTTCTGGT CCAATGTCTG TGATGAGGAA ATGGATTTGG CCATTGAGGC TTCAGAGGCA 
GCAGAGCAAG GACGCCCCCC GGAGCACACC AGCAAATTTT ACGCCAAGGG AGCACTGCAG 
TACTTGGTGC CCATCCTCAC ACAGACACTG ACTAAACAGG ATGAAAACGA TGACGACGAT 
GACTGGAACC CTTGCAAAGC AGCTGGGGTG TGCCTCATGC TCCTGTCCAC CTGCTGTGAA 
GATGACATTG TGCCGCATGT CCTTCCCTTT ATTAAAGAGC ACATCAAGAA CCCTGACTGG 
CGATACCGGG ATGCAGCAGT GATGGCTTTT GGCAGTATCT TGGAAGGACC AGAGCCTAAT 
CAACTGAAAC CATTAGTCAT ACAGGCTATG CCCACCCTAA TAGAACTAAT GAAAGACCCC 
AGTGTAGTTG TTCGAGACAC AACAGCGTGG ACTGTGGGCA GGATCTGTGA GCTGCTGCCT 
GAAGCCGCCA TCAACGATGT CTACCTGGCA CCCCTTTTAC AGTGTCTGAT TGAGGGCCTC 
AGTGCTGAGC CCAGGGTGGC TTCAAATGTG TGCTGGGCTT TTTCCAGTCT GGCTGAAGCT 
GCGTATGAAG CTGCAGATGT AGCTGATGAT CAAGAAGAAC CAGCCACCTA TTGTCTGTCT 
TCTTCCTTTG AACTTATAGT TCAGAAGCTA TTGGAGACCA CCGACAGACC CGATGGACAC 
CAGAATAACC TGAGAAGCTC TGCGTATGAG TCTCTCATGG AAATCGTAAA GAACAGTGCC 
AAGGATTGTT ACCCTGCCGT GCAGAAGACC ACCCTGGTCA TTATGGAACG GCTGCAGCAG 
GTGCTTCAGA TGGAGTCCCA TATCCAGAGC ACATCCGACA GAATCCAGTT CAATGACCTC 
CAGTCTCTAC TCTGCGCGAC TCTTCAGAAT GTTCTCCGGA AAGTGCAGCA TCAAGATGCT 
CTGCAGATCT CTGATGTGGT CATGGCCTCC CTGTTAAGGA TGTTCCAAAG CACAGCTGGG 
TCTGGGGGAG TGCAAGAAGA TGCCCTGATG GCAGTTAGCA CACTGGTGGA AGTGTTGGGT 
GGTGAATTCC TCAAGTACAT GGAGGCCTTT AAACCATTCC TGGGCATTGG ACTGAAAAAT 
TATGCTGAGT ACCAGGTATG TTTGGCAGCT GTTGGCTTAG TTGGAGACTT GTGCCGAGCC 
CTGCAGTCTA ACATCTTGCC TTTCTGTGAC GAGGTGATGC AGCTGCTCCT GGAGAACTTG 
GGGAATGAGA ATGTCCACAG GTCTGTGAAG CCACAGATTC TGTCTGTGTT TGGTGATATT 
GCTCTTGCCA TTGGTGGAGA GTTTAAAAAA TACTTAGAGG TTGTATTGAA TACTCTACAG 
CAGGCCTCCC AAGCCCAGGT TGACAAGTCA GACTTTGACA TGGTGGATTA TCTGAATGAG 
CTAAGAGAAA GCTGCTTGGA AGCTTATACG GGAATCGTCC AGGGATTGAA GGGAGATCAG 
GAAAACGTAC ACCCGGATGT AATGCTGGTA CAGCCCAGAG TAGAATTTAT TTTGTCTTTT 
ATTGATCACA TTGCTGGAGA TGAGGATCAT ACGGACGGAG TGGTAGCCTG TGCTGCTGGT 
CTGATAGGGG ACTTGTGTAC AGCCTTCGGG AAGGATGTAC TGAAGTTAGT AGAAGCTAGG 
CCAATGATCC ATGAACTATT AACTGAAGGG CGGAGATCGA AGACTAACAA AGCAAAGACC 
CTCGCTACGT GGGCAACCAA GGAACTGAGG AAACTGAAGA ACCAGGCTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032405.3
CDS	308..2938
Translation	MELITILEKTVSPDRLELEAAQKFLERAAVENLPTFLVELSRVLANPGNSQVARVAAGLQIKNSLTSKDPDIKAQYQQRWLAIDANARREVKNYVLQTLGTETYRPSSASQCVAGIACAEIPVSQWPELIPQLVANVTNPNSTEHMKESTLEAIGYICQDIDPEQLQDKSNEILTAIIQGMRKEEPSNNVKLAATNALLNSLEFTKANFDKESERHFIMQVVCEATQCPDTRVRVAALQNLVKIMSLYYQYMETYMGPALFAITIEAMKSDIDEVALQGIEFWSNVCDEEMDLAIEASEAAEQGRPPEHTSKFYAKGALQYLVPILTQTLTKQDENDDDDDWNPCKAAGVCLMLLSTCCEDDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGSILEGPEPNQLKPLVIQAMPTLIELMKDPSVVVRDTTAWTVGRICELLPEAAINDVYLAPLLQCLIEGLSAEPRVASNVCWAFSSLAEAAYEAADVADDQEEPATYCLSSSFELIVQKLLETTDRPDGHQNNLRSSAYESLMEIVKNSAKDCYPAVQKTTLVIMERLQQVLQMESHIQSTSDRIQFNDLQSLLCATLQNVLRKVQHQDALQISDVVMASLLRMFQSTAGSGGVQEDALMAVSTLVEVLGGEFLKYMEAFKPFLGIGLKNYAEYQVCLAAVGLVGDLCRALQSNILPFCDEVMQLLLENLGNENVHRSVKPQILSVFGDIALAIGGEFKKYLEVVLNTLQQASQAQVDKSDFDMVDYLNELRESCLEAYTGIVQGLKGDQENVHPDVMLVQPRVEFILSFIDHIAGDEDHTDGVVACAAGLIGDLCTAFGKDVLKLVEARPMIHELLTEGRRSKTNKAKTLATWATKELRKLKNQA

Target ORF information:

RefSeq Version	NM_008379.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus karyopherin (importin) beta 1 (Kpnb1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008379.3

ORF Insert Sequence:

ATGGAGCTCA TAACCATCCT CGAGAAGACC GTGTCTCCGG ATCGGCTGGA GCTGGAAGCG 
GCGCAGAAGT TCCTCGAGCG TGCGGCCGTG GAGAATCTGC CCACGTTCCT TGTGGAACTG 
TCCAGAGTGC TGGCAAACCC AGGAAACAGT CAGGTTGCCA GAGTTGCAGC TGGTCTACAA 
ATTAAGAACT CTTTGACATC GAAAGATCCA GATATCAAGG CACAATACCA GCAGAGGTGG 
CTCGCTATTG ATGCTAATGC TCGACGGGAA GTCAAGAACT ATGTTTTGCA GACGTTGGGC 
ACAGAAACGT ACCGGCCTAG TTCGGCCTCA CAGTGTGTGG CTGGTATTGC TTGTGCAGAG 
ATCCCAGTAA GCCAGTGGCC AGAGCTAATT CCTCAGCTGG TAGCCAATGT CACAAACCCC 
AACAGCACAG AGCATATGAA AGAGTCCACA TTGGAAGCTA TTGGTTACAT TTGCCAAGAT 
ATAGACCCAG AGCAGCTACA GGATAAGTCC AATGAGATCC TGACTGCCAT AATCCAGGGG 
ATGAGGAAGG AGGAGCCTAG TAACAATGTG AAGCTGGCTG CTACCAATGC ACTCCTGAAC 
TCACTAGAGT TCACCAAAGC AAACTTTGAC AAAGAGTCTG AAAGGCACTT TATCATGCAA 
GTGGTCTGTG AAGCCACACA GTGTCCAGAC ACAAGGGTAA GAGTGGCTGC TTTACAGAAT 
CTAGTGAAGA TAATGTCCTT GTATTACCAG TACATGGAGA CATACATGGG TCCTGCCCTT 
TTTGCAATCA CAATTGAAGC AATGAAAAGT GACATTGATG AGGTGGCTCT CCAAGGGATA 
GAGTTCTGGT CCAATGTCTG TGATGAGGAA ATGGATTTGG CCATTGAGGC TTCAGAGGCA 
GCAGAGCAAG GACGCCCCCC GGAGCACACC AGCAAATTTT ACGCCAAGGG AGCACTGCAG 
TACTTGGTGC CCATCCTCAC ACAGACACTG ACTAAACAGG ATGAAAACGA TGACGACGAT 
GACTGGAACC CTTGCAAAGC AGCTGGGGTG TGCCTCATGC TCCTGTCCAC CTGCTGTGAA 
GATGACATTG TGCCGCATGT CCTTCCCTTT ATTAAAGAGC ACATCAAGAA CCCTGACTGG 
CGATACCGGG ATGCAGCAGT GATGGCTTTT GGCAGTATCT TGGAAGGACC AGAGCCTAAT 
CAACTGAAAC CATTAGTCAT ACAGGCTATG CCCACCCTAA TAGAACTAAT GAAAGACCCC 
AGTGTAGTTG TTCGAGACAC AACAGCGTGG ACTGTGGGCA GGATCTGTGA GCTGCTGCCT 
GAAGCCGCCA TCAACGATGT CTACCTGGCA CCCCTTTTAC AGTGTCTGAT TGAGGGCCTC 
AGTGCTGAGC CCAGGGTGGC TTCAAATGTG TGCTGGGCTT TTTCCAGTCT GGCTGAAGCT 
GCGTATGAAG CTGCAGATGT AGCTGATGAT CAAGAAGAAC CAGCCACCTA TTGTCTGTCT 
TCTTCCTTTG AACTTATAGT TCAGAAGCTA TTGGAGACCA CCGACAGACC CGATGGACAC 
CAGAATAACC TGAGAAGCTC TGCGTATGAG TCTCTCATGG AAATCGTAAA GAACAGTGCC 
AAGGATTGTT ACCCTGCCGT GCAGAAGACC ACCCTGGTCA TTATGGAACG GCTGCAGCAG 
GTGCTTCAGA TGGAGTCCCA TATCCAGAGC ACATCCGACA GAATCCAGTT CAATGACCTC 
CAGTCTCTAC TCTGCGCGAC TCTTCAGAAT GTTCTCCGGA AAGTGCAGCA TCAAGATGCT 
CTGCAGATCT CTGATGTGGT CATGGCCTCC CTGTTAAGGA TGTTCCAAAG CACAGCTGGG 
TCTGGGGGAG TGCAAGAAGA TGCCCTGATG GCAGTTAGCA CACTGGTGGA AGTGTTGGGT 
GGTGAATTCC TCAAGTACAT GGAGGCCTTT AAACCATTCC TGGGCATTGG ACTGAAAAAT 
TATGCTGAGT ACCAGGTATG TTTGGCAGCT GTTGGCTTAG TTGGAGACTT GTGCCGAGCC 
CTGCAGTCTA ACATCTTGCC TTTCTGTGAC GAGGTGATGC AGCTGCTCCT GGAGAACTTG 
GGGAATGAGA ATGTCCACAG GTCTGTGAAG CCACAGATTC TGTCTGTGTT TGGTGATATT 
GCTCTTGCCA TTGGTGGAGA GTTTAAAAAA TACTTAGAGG TTGTATTGAA TACTCTACAG 
CAGGCCTCCC AAGCCCAGGT TGACAAGTCA GACTTTGACA TGGTGGATTA TCTGAATGAG 
CTAAGAGAAA GCTGCTTGGA AGCTTATACG GGAATCGTCC AGGGATTGAA GGGAGATCAG 
GAAAACGTAC ACCCGGATGT AATGCTGGTA CAGCCCAGAG TAGAATTTAT TTTGTCTTTT 
ATTGATCACA TTGCTGGAGA TGAGGATCAT ACGGACGGAG TGGTAGCCTG TGCTGCTGGT 
CTGATAGGGG ACTTGTGTAC AGCCTTCGGG AAGGATGTAC TGAAGTTAGT AGAAGCTAGG 
CCAATGATCC ATGAACTATT AACTGAAGGG CGGAGATCGA AGACTAACAA AGCAAAGACC 
CTCGCTACGT GGGCAACCAA GGAACTGAGG AAACTGAAGA ACCAGGCTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Reactive oxygen species regulate axonal regeneration through the release of exosomal NADPH oxidase 2 complexes into injured axons.
Nature cell biology20(3)307-319(2018 03)
Hervera A,De Virgiliis F,Palmisano I,Zhou L,Tantardini E,Kong G,Hutson T,Danzi MC,Perry RB,Santos CXC,Kapustin AN,Fleck RA,Del Río JA,Carroll T,Lemmon V,Bixby JL,Shah AM,Fainzilber M,Di Giovanni S

AMP Kinase Activation Alters Oxidant-Induced Stress Granule Assembly by Modulating Cell Signaling and Microtubule Organization.
Molecular pharmacology90(4)460-8(2016 10)
Mahboubi H,Koromilas AE,Stochaj U

Nucleolin-Mediated RNA Localization Regulates Neuron Growth and Cycling Cell Size.
Cell reports16(6)1664-1676(2016 08)
Perry RB,Rishal I,Doron-Mandel E,Kalinski AL,Medzihradszky KF,Terenzio M,Alber S,Koley S,Lin A,Rozenbaum M,Yudin D,Sahoo PK,Gomes C,Shinder V,Geraisy W,Huebner EA,Woolf CJ,Yaron A,Burlingame AL,Twiss JL,Fainzilber M

The importin protein karyopherin-β1 regulates the mice fibroblast-like synoviocytes inflammation via facilitating nucleus transportation of STAT3 transcription factor.
Biochemical and biophysical research communications471(4)553-9(2016 Mar)
Sun C,Yu Z,Wang Y,Tao T

KPNβ1 promotes palmitate-induced insulin resistance via NF-κB signaling in hepatocytes.
Journal of physiology and biochemistry71(4)763-72(2015 Dec)
Wang S,Zhao Y,Xia N,Zhang W,Tang Z,Wang C,Zhu X,Cui S

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Kpnb1 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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