Ide cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ide
Entrez Gene ID	15925
Full Name	insulin degrading enzyme
Synonyms	1300012G03Rik,4833415K22Rik,AA675336,AI507533
General protein information	Preferred Names insulin degrading enzyme Names insulin-degrading enzyme insulin protease insulinase insulysin
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 19 Map Location: 19 C2\|19 32.24 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_031156.3	NP_112419.3	insulin-degrading enzyme

Pathways from BioSystems

Homologies

Kluyveromyces lactis	KLLA0E05105g	XP_454175.1
Bos taurus (cattle)	IDE	NP_001069317.1
Danio rerio (zebrafish)	ide	NP_001082994.1
Caenorhabditis elegans (roundworm)	CELE_Y70C5C.1	NP_507226.2
Caenorhabditis elegans (roundworm)	C28F5.4	NP_495575.2
Arabidopsis thaliana (thale cress)	AT3G57470	NP_001118852.1
Magnaporthe oryzae (rice blast fungus)	MGG_13149	XP_003710564.1
Xenopus tropicalis (tropical clawed frog)	ide	XP_002939138.2
Drosophila melanogaster (fruit fly)	Ide	NP_524182.3
Caenorhabditis elegans (roundworm)	C02G6.2	NP_504531.2
Saccharomyces cerevisiae (baker's yeast)	STE23	NP_013493.2
Neurospora crassa	NCU00481	XP_956166.1
Homo sapiens (human)	IDE	NP_004960.2
Pan troglodytes (chimpanzee)	IDE	XP_507922.2
Macaca mulatta (Rhesus monkey)	IDE	XP_001090249.1
Oryza sativa (rice)	Os07g0570300	NP_001060044.1
Schizosaccharomyces pombe (fission yeast)	mug138	NP_593966.1
Canis lupus familiaris (dog)	IDE	XP_534963.3
Mus musculus (house mouse)	Ide	NP_112419.3
Rattus norvegicus (Norway rat)	Ide	NP_037291.1
Gallus gallus (chicken)	IDE	XP_421686.4
Caenorhabditis elegans (roundworm)	F44E7.4	NP_741542.1
Caenorhabditis elegans (roundworm)	C02G6.1	NP_504532.1
Arabidopsis thaliana (thale cress)	AT2G41790	NP_181710.1
Eremothecium gossypii	AGOS_AER053C	NP_984913.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010351	XP_311589.4

Gene Ontology
Bibliography

Related articles in PubMed

Knockout of insulin-degrading enzyme leads to mice testicular morphological changes and impaired sperm quality.
Meneses MJ, Borges DO, Dias TR, Martins FO, Oliveira PF, Macedo MP, Alves MG
Molecular and cellular endocrinology48611-17(2019 04)

Liver-specific ablation of insulin-degrading enzyme causes hepatic insulin resistance and glucose intolerance, without affecting insulin clearance in mice.
Villa-Pérez P, Merino B, Fernández-Díaz CM, Cidad P, Lobatón CD, Moreno A, Muturi HT, Ghadieh HE, Najjar SM, Leissring MA, Cózar-Castellano I, Perdomo G
Metabolism: clinical and experimental881-11(2018 11)

Insulin degrading enzyme contributes to the pathology in a mixed model of Type 2 diabetes and Alzheimer's disease: possible mechanisms of IDE in T2D and AD.
Li H, Wu J, Zhu L, Sha L, Yang S, Wei J, Ji L, Tang X, Mao K, Cao L, Wei N, Xie W, Yang Z
Bioscience reports38(1)(2018 02)

cAMP/PKA signaling pathway contributes to neuronal apoptosis via regulating IDE expression in a mixed model of type 2 diabetes and Alzheimer's disease.
Li H, Yang S, Wu J, Ji L, Zhu L, Cao L, Huang J, Jiang Q, Wei J, Liu M, Mao K, Wei N, Xie W, Yang Z
Journal of cellular biochemistry119(2)1616-1626(2018 02)

Bile acid TUDCA improves insulin clearance by increasing the expression of insulin-degrading enzyme in the liver of obese mice.
Vettorazzi JF, Kurauti MA, Soares GM, Borck PC, Ferreira SM, Branco RCS, Michelone LSL, Boschero AC, Junior JMC, Carneiro EM
Scientific reports7(1)14876(2017 11)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Ide gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ide cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu16406	NM_031156.3 Latest version!	Mus musculus insulin degrading enzyme (Ide), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$559.30 $799.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ide ( NM_031156.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_112419.3 Mus musculus insulin degrading enzyme (Ide), mRNA.

Price & Availability↑

CloneID	OMu16406
Clone ID Related Accession (Same CDS sequence)	NM_031156.3
Accession Version	NM_031156.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3060bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1573747200000
Organism	Mus musculus(house mouse)
Product	insulin-degrading enzyme
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK004972.2 and AC161238.7. On Mar 6, 2013 this sequence version replaced NM_031156.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660811.135860.1, SRR1660817.63313.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCGGAACG GGCTCGTGTG GCTGCTGCAC CCCGCGCTGC CCGGCACCTT GCGCTCCATC 
CTCGGCGCCC GCCCGCCGCC CGCGAAGCTA CTGTGTGGAT TCCCAAAACA GACTTACAGC 
ACAATGAGTA ATCCGGCCAT CCAGAGAATA GAAGACCAAA TTGTCAAGTC TCCTGAAGAC 
AAACGGGAAT ACCGTGGACT AGAGCTGGCC AATGGCATCA AAGTGCTTCT CATCAGCGAT 
CCCACCACAG ACAAGTCCTC AGCGGCCCTC GATGTGCACA TAGGTTCACT GTCAGACCCT 
CCAAATATTC CTGGCTTAAG TCATTTTTGT GAACATATGC TGTTTTTGGG AACCAAGAAA 
TATCCTAAAG AAAATGAATA TAGCCAGTTT CTCAGTGAAC ATGCTGGAAG TTCAAATGCA 
TTCACCAGTG GAGAACACAC CAATTATTAT TTCGATGTTT CCCATGAACA CTTGGAAGGA 
GCCCTGGACA GGTTTGCGCA GTTTTTCCTG TGCCCCTTGT TTGATGCAAG TTGTAAAGAC 
AGAGAGGTGA ACGCTGTCGA TTCAGAACAT GAGAAGAATG TGATGAACGA TGCCTGGAGA 
CTCTTCCAGC TGGAAAAGGC TACGGGGAAC CCCAAACACC CCTTCAGCAA ATTTGGGACA 
GGAAACAAAT ATACTCTAGA GACTCGGCCC AACCAAGAAG GCATCGACGT AAGGGAAGAG 
CTCTTGAAAT TTCACTCTAC GTATTATTCG TCCAATCTGA TGGCGATTTG TGTTTTAGGT 
CGAGAATCCT TAGACGACCT CACTAACCTG GTGGTGAAGC TGTTCTCCGA GGTGGAGAAC 
AAGAACGTTC CTCTGCCTGA GTTCCCTGAG CACCCTTTCC AGGAAGAGCA TCTCAGGCAA 
CTTTATAAAA TAGTACCCAT TAAGGATATT AGAAATCTTT ATGTGACATT TCCCATACCA 
GACCTTCAGC AGTACTACAA ATCCAATCCT GGTCATTATC TTGGTCATCT AATTGGGCAC 
GAAGGTCCTG GAAGCCTGTT GTCAGAACTC AAATCAAAGG GCTGGGTGAA TACCCTGGTT 
GGTGGACAGA AGGAAGGAGC CCGAGGTTTT ATGTTTTTTA TCATTAATGT GGACTTAACT 
GAAGAAGGGT TATTGCACGT TGAAGATATA ATTTTGCACA TGTTTCAATA CATTCAGAAG 
CTACGTGCAG AAGGACCTCA AGAATGGGTT TTCCAAGAGT GCAAGGACTT GAATGCTGTT 
GCTTTCAGAT TTAAAGATAA AGAGAGACCA CGAGGCTATA CGTCCAAGAT TGCAGGAAAG 
TTGCACTATT ATCCCCTAAA TGGAGTGCTC ACAGCTGAAT ATCTATTGGA GGAATTTAGA 
CCCGACTTGA TAGACATGGT TCTTGATAAA CTCAGACCAG AAAATGTGCG GGTGGCAATA 
GTTTCCAAAT CATTTGAAGG GAAAACTGAC CGCACAGAGC AGTGGTATGG AACACAGTAT 
AAGCAAGAAG CTATCCCAGA GGACATCATT CAGAAATGGC AAAATGCTGA CCTTAATGGA 
AAATTTAAGC TTCCAACAAA GAATGAATTT ATTCCCACAA ATTTTGAGAT TTTGTCATTA 
GAAAAAGATG CAACACCATA CCCTGCTCTT ATTAAGGATA CAGCCATGAG TAAGCTGTGG 
TTCAAACAAG ATGATAAATT TTTCTTGCCG AAAGCTTGTC TCAACTTTGA ATTTTTCAGC 
CCGTTTGCTT ATGTGGACCC CTTGCACTGT AACATGGCCT ATTTGTACCT TGAGCTCCTC 
AAAGACTCAC TCAACGAGTA TGCATATGCA GCAGAGCTAG CAGGCCTGAG CTATGACCTC 
CAAAATACCA TCTATGGGAT GTATCTCTCA GTGAAAGGTT ACAATGACAA ACAGCCAATT 
TTGCTGAAGA AGATCACCGA GAAAATGGCT ACTTTTGAGA TTGATAAGAA GAGATTTGAA 
ATTATCAAAG AGGCCTATAT GCGATCTCTT AATAACTTCC GGGCTGAGCA GCCTCACCAG 
CATGCCATGT ACTACCTCCG CTTGCTGATG ACTGAAGTGG CCTGGACTAA AGATGAGCTA 
AAAGAAGCCC TTGACGATGT TACCCTCCCC CGACTTAAGG CCTTCATACC TCAGCTGCTG 
TCACGGCTGC ATATTGAAGC ACTTCTCCAT GGAAACATAA CCAAGCAGGC TGCCTTAGGA 
GTTATGCAGA TGGTAGAAGA CACTCTTATC GAGCATGCTC ACACCAAACC TCTCCTTCCA 
AGTCAGCTAG TCCGGTACAG AGAAGTCCAG CTCCCTGACA GAGGATGGTT TGTTTATCAG 
CAGAGGAATG AAGTTCACAA TAACTGCGGC ATCGAGATCT ACTACCAGAC AGACATGCAG 
AGCACCTCGG AGAACATGTT CCTGGAGCTG TTTTGCCAGA TTATCTCGGA GCCTTGCTTC 
AATACCCTGC GCACCAAGGA GCAGCTTGGC TATATTGTCT TCAGTGGACC CCGTCGGGCC 
AACGGTATCC AAGGCTTGCG CTTCATCATC CAGTCAGAAA AACCACCCCA CTACCTGGAG 
AGCAGAGTAG AAGCCTTCTT GATTACCATG GAAAAGGCCA TAGAGGACAT GACAGAGGAG 
GCGTTCCAAA AACACATTCA AGCACTAGCG ATTCGGCGAC TCGACAAACC AAAGAAACTC 
TCTGCGGAGT GTGCTAAATA CTGGGGGGAA ATCATCTCGC AGCAGTACAA TTACGACAGA 
GATAACATAG AAGTTGCATA TTTAAAGACA CTTACCAAGG ACGATATCAT CAGATTCTAC 
CAGGAAATGT TGGCTGTCGA CGCACCGAGG AGACATAAAG TGTCTGTCCA TGTTCTTGCC 
AGGGAAATGG ATTCTTGTCC TGTTGTTGGA GAGTTCCCCT CTCAGAATGA TATAAACTTG 
TCCGAAGCGC CACCCTTGCC ACAACCTGAA GTGATTCACA ACATGACTGA GTTCAAGCGT 
GGCCTGCCAC TGTTTCCCCT CGTGAAACCA CATATTAACT TCATGGCTGC AAAACTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112419.3
CDS	27..3086
Translation	MRNGLVWLLHPALPGTLRSILGARPPPAKLLCGFPKQTYSTMSNPAIQRIEDQIVKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIPGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDASCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVREELLKFHSTYYSSNLMAICVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLRQLYKIVPIKDIRNLYVTFPIPDLQQYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGKLHYYPLNGVLTAEYLLEEFRPDLIDMVLDKLRPENVRVAIVSKSFEGKTDRTEQWYGTQYKQEAIPEDIIQKWQNADLNGKFKLPTKNEFIPTNFEILSLEKDATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKITEKMATFEIDKKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGVMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKAIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNYDRDNIEVAYLKTLTKDDIIRFYQEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPSQNDINLSEAPPLPQPEVIHNMTEFKRGLPLFPLVKPHINFMAAKL

Target ORF information:

RefSeq Version	NM_031156.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus insulin degrading enzyme (Ide), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031156.3

ORF Insert Sequence:

ATGCGGAACG GGCTCGTGTG GCTGCTGCAC CCCGCGCTGC CCGGCACCTT GCGCTCCATC 
CTCGGCGCCC GCCCGCCGCC CGCGAAGCTA CTGTGTGGAT TCCCAAAACA GACTTACAGC 
ACAATGAGTA ATCCGGCCAT CCAGAGAATA GAAGACCAAA TTGTCAAGTC TCCTGAAGAC 
AAACGGGAAT ACCGTGGACT AGAGCTGGCC AATGGCATCA AAGTGCTTCT CATCAGCGAT 
CCCACCACAG ACAAGTCCTC AGCGGCCCTC GATGTGCACA TAGGTTCACT GTCAGACCCT 
CCAAATATTC CTGGCTTAAG TCATTTTTGT GAACATATGC TGTTTTTGGG AACCAAGAAA 
TATCCTAAAG AAAATGAATA TAGCCAGTTT CTCAGTGAAC ATGCTGGAAG TTCAAATGCA 
TTCACCAGTG GAGAACACAC CAATTATTAT TTCGATGTTT CCCATGAACA CTTGGAAGGA 
GCCCTGGACA GGTTTGCGCA GTTTTTCCTG TGCCCCTTGT TTGATGCAAG TTGTAAAGAC 
AGAGAGGTGA ACGCTGTCGA TTCAGAACAT GAGAAGAATG TGATGAACGA TGCCTGGAGA 
CTCTTCCAGC TGGAAAAGGC TACGGGGAAC CCCAAACACC CCTTCAGCAA ATTTGGGACA 
GGAAACAAAT ATACTCTAGA GACTCGGCCC AACCAAGAAG GCATCGACGT AAGGGAAGAG 
CTCTTGAAAT TTCACTCTAC GTATTATTCG TCCAATCTGA TGGCGATTTG TGTTTTAGGT 
CGAGAATCCT TAGACGACCT CACTAACCTG GTGGTGAAGC TGTTCTCCGA GGTGGAGAAC 
AAGAACGTTC CTCTGCCTGA GTTCCCTGAG CACCCTTTCC AGGAAGAGCA TCTCAGGCAA 
CTTTATAAAA TAGTACCCAT TAAGGATATT AGAAATCTTT ATGTGACATT TCCCATACCA 
GACCTTCAGC AGTACTACAA ATCCAATCCT GGTCATTATC TTGGTCATCT AATTGGGCAC 
GAAGGTCCTG GAAGCCTGTT GTCAGAACTC AAATCAAAGG GCTGGGTGAA TACCCTGGTT 
GGTGGACAGA AGGAAGGAGC CCGAGGTTTT ATGTTTTTTA TCATTAATGT GGACTTAACT 
GAAGAAGGGT TATTGCACGT TGAAGATATA ATTTTGCACA TGTTTCAATA CATTCAGAAG 
CTACGTGCAG AAGGACCTCA AGAATGGGTT TTCCAAGAGT GCAAGGACTT GAATGCTGTT 
GCTTTCAGAT TTAAAGATAA AGAGAGACCA CGAGGCTATA CGTCCAAGAT TGCAGGAAAG 
TTGCACTATT ATCCCCTAAA TGGAGTGCTC ACAGCTGAAT ATCTATTGGA GGAATTTAGA 
CCCGACTTGA TAGACATGGT TCTTGATAAA CTCAGACCAG AAAATGTGCG GGTGGCAATA 
GTTTCCAAAT CATTTGAAGG GAAAACTGAC CGCACAGAGC AGTGGTATGG AACACAGTAT 
AAGCAAGAAG CTATCCCAGA GGACATCATT CAGAAATGGC AAAATGCTGA CCTTAATGGA 
AAATTTAAGC TTCCAACAAA GAATGAATTT ATTCCCACAA ATTTTGAGAT TTTGTCATTA 
GAAAAAGATG CAACACCATA CCCTGCTCTT ATTAAGGATA CAGCCATGAG TAAGCTGTGG 
TTCAAACAAG ATGATAAATT TTTCTTGCCG AAAGCTTGTC TCAACTTTGA ATTTTTCAGC 
CCGTTTGCTT ATGTGGACCC CTTGCACTGT AACATGGCCT ATTTGTACCT TGAGCTCCTC 
AAAGACTCAC TCAACGAGTA TGCATATGCA GCAGAGCTAG CAGGCCTGAG CTATGACCTC 
CAAAATACCA TCTATGGGAT GTATCTCTCA GTGAAAGGTT ACAATGACAA ACAGCCAATT 
TTGCTGAAGA AGATCACCGA GAAAATGGCT ACTTTTGAGA TTGATAAGAA GAGATTTGAA 
ATTATCAAAG AGGCCTATAT GCGATCTCTT AATAACTTCC GGGCTGAGCA GCCTCACCAG 
CATGCCATGT ACTACCTCCG CTTGCTGATG ACTGAAGTGG CCTGGACTAA AGATGAGCTA 
AAAGAAGCCC TTGACGATGT TACCCTCCCC CGACTTAAGG CCTTCATACC TCAGCTGCTG 
TCACGGCTGC ATATTGAAGC ACTTCTCCAT GGAAACATAA CCAAGCAGGC TGCCTTAGGA 
GTTATGCAGA TGGTAGAAGA CACTCTTATC GAGCATGCTC ACACCAAACC TCTCCTTCCA 
AGTCAGCTAG TCCGGTACAG AGAAGTCCAG CTCCCTGACA GAGGATGGTT TGTTTATCAG 
CAGAGGAATG AAGTTCACAA TAACTGCGGC ATCGAGATCT ACTACCAGAC AGACATGCAG 
AGCACCTCGG AGAACATGTT CCTGGAGCTG TTTTGCCAGA TTATCTCGGA GCCTTGCTTC 
AATACCCTGC GCACCAAGGA GCAGCTTGGC TATATTGTCT TCAGTGGACC CCGTCGGGCC 
AACGGTATCC AAGGCTTGCG CTTCATCATC CAGTCAGAAA AACCACCCCA CTACCTGGAG 
AGCAGAGTAG AAGCCTTCTT GATTACCATG GAAAAGGCCA TAGAGGACAT GACAGAGGAG 
GCGTTCCAAA AACACATTCA AGCACTAGCG ATTCGGCGAC TCGACAAACC AAAGAAACTC 
TCTGCGGAGT GTGCTAAATA CTGGGGGGAA ATCATCTCGC AGCAGTACAA TTACGACAGA 
GATAACATAG AAGTTGCATA TTTAAAGACA CTTACCAAGG ACGATATCAT CAGATTCTAC 
CAGGAAATGT TGGCTGTCGA CGCACCGAGG AGACATAAAG TGTCTGTCCA TGTTCTTGCC 
AGGGAAATGG ATTCTTGTCC TGTTGTTGGA GAGTTCCCCT CTCAGAATGA TATAAACTTG 
TCCGAAGCGC CACCCTTGCC ACAACCTGAA GTGATTCACA ACATGACTGA GTTCAAGCGT 
GGCCTGCCAC TGTTTCCCCT CGTGAAACCA CATATTAACT TCATGGCTGC AAAACTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Knockout of insulin-degrading enzyme leads to mice testicular morphological changes and impaired sperm quality.
Molecular and cellular endocrinology48611-17(2019 04)
Meneses MJ,Borges DO,Dias TR,Martins FO,Oliveira PF,Macedo MP,Alves MG

Liver-specific ablation of insulin-degrading enzyme causes hepatic insulin resistance and glucose intolerance, without affecting insulin clearance in mice.
Metabolism: clinical and experimental881-11(2018 11)
Villa-Pérez P,Merino B,Fernández-Díaz CM,Cidad P,Lobatón CD,Moreno A,Muturi HT,Ghadieh HE,Najjar SM,Leissring MA,Cózar-Castellano I,Perdomo G

Insulin degrading enzyme contributes to the pathology in a mixed model of Type 2 diabetes and Alzheimer's disease: possible mechanisms of IDE in T2D and AD.
Bioscience reports38(1)(2018 02)
Li H,Wu J,Zhu L,Sha L,Yang S,Wei J,Ji L,Tang X,Mao K,Cao L,Wei N,Xie W,Yang Z

cAMP/PKA signaling pathway contributes to neuronal apoptosis via regulating IDE expression in a mixed model of type 2 diabetes and Alzheimer's disease.
Journal of cellular biochemistry119(2)1616-1626(2018 02)
Li H,Yang S,Wu J,Ji L,Zhu L,Cao L,Huang J,Jiang Q,Wei J,Liu M,Mao K,Wei N,Xie W,Yang Z

Bile acid TUDCA improves insulin clearance by increasing the expression of insulin-degrading enzyme in the liver of obese mice.
Scientific reports7(1)14876(2017 11)
Vettorazzi JF,Kurauti MA,Soares GM,Borck PC,Ferreira SM,Branco RCS,Michelone LSL,Boschero AC,Junior JMC,Carneiro EM

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Ide cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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