H2-DMb1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	H2-DMb1
Entrez Gene ID	14999
Full Name	histocompatibility 2, class II, locus Mb1
Synonyms	AI385589,H-2Mb1,H2-Mb1
General protein information	Preferred Names histocompatibility 2, class II, locus Mb1 Names class II histocompatibility antigen, M beta 1 chain H2-M beta 1 chain H2-M beta1 MHC class II antigen Mb1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 17 Map Location: 17 B1\|17 17.98 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_010387.3	NP_034517.2	class II histocompatibility antigen, M beta 1 chain precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	BOLA-DMB	NP_001035571.1
Pan troglodytes (chimpanzee)	PATR-DMB	NP_001127814.1
Mus musculus (house mouse)	H2-DMb1	NP_034517.2
Homo sapiens (human)	HLA-DMB	NP_002109.2
Canis lupus familiaris (dog)	DLA-DMB	NP_001257999.1
Gallus gallus (chicken)	BMA2	NP_001128638.1
Xenopus tropicalis (tropical clawed frog)	LOC100495183	XP_002942059.1
Mus musculus (house mouse)	H2-DMb2	NP_034518.1
Macaca mulatta (Rhesus monkey)	MAMU-DMB	XP_002803734.1

Gene Ontology
Bibliography

Related articles in PubMed

The QTL within the H2 Complex Involved in the Control of Tuberculosis Infection in Mice Is the Classical Class II H2-Ab1 Gene.
Logunova N, Korotetskaya M, Polshakov V, Apt A
PLoS genetics11(11)e1005672(2015 Nov)

H2-Mbeta 1 and H2-Mbeta 2 heterodimers equally promote clip removal in I-A(q) molecules from autoimmune-prone DBA/1 mice.
Walter W, Scheuer C, Loos M, Reichert TE, Maeurer MJ
The Journal of biological chemistry276(14)11086-91(2001 Apr)

MHC class II antigen presentation pathway in murine tumours: tumour evasion from immunosurveillance?
Walter W, Lingnau K, Schmitt E, Loos M, Maeurer MJ
British journal of cancer83(9)1192-201(2000 Nov)

The mouse as a model for the effects of MHC genes on human disease.
Allcock RJ, Martin AM, Price P
Immunology today21(7)328-32(2000 Jul)

Coordinate regulation of B cell differentiation by the transcription factors EBF and E2A.
O'Riordan M, Grosschedl R
Immunity11(1)21-31(1999 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following H2-DMb1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the H2-DMb1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu23757	NM_010387.3 Latest version!	Mus musculus histocompatibility 2, class II, locus Mb1 (H2-DMb1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$174.30 $249.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

H2-DMb1 ( NM_010387.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034517.2 Mus musculus histocompatibility 2, class II, locus Mb1 (H2-DMb1), mRNA.

Price & Availability↑

CloneID	OMu23757
Clone ID Related Accession (Same CDS sequence)	NM_010387.3
Accession Version	NM_010387.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 786bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1572796800000
Organism	Mus musculus(house mouse)
Product	class II histocompatibility antigen, M beta 1 chain precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK032745.1. On Jul 2, 2014 this sequence version replaced NM_010387.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK032745.1, AK170866.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGCTGCAC TCTGGCTGCT GCTGCTGGTC CTCAGTCTGG ACTGTATGGG GGCAGGTGGC 
TTTGTGGCTC ATGTGGAAAG CACGTGCGTG CTGGATGATG CTGGGACCCC ACAGGACTTC 
ACATACTGTG TTTCCTTCAA CAAAGATCTG CTGGCCTGCT GGGATCCAGA TGTGGGAAAA 
ATAGTCCCCT GTGAATTTGG GGTGCTGTAT CCATGGGCCG AAAATTTTTC AAGGATCCTC 
AACAAAGAAG AGAGCCTTCT CCAGCGTTTG CAAAACGGGC TTCTGGACTG TGCCTCCCAC 
ACCCAGCCCT TCTGGAATGC GCTGACCCAC AGAACGAGAG CGCCATCTGT CCGAGTAGCC 
CAAACCACAC CTTTTAACAC AAGGGAGCCG GTGATGCTGG CCTGCTACGT CTGGGGCTTC 
TATCCAGCGG ATGTGACCAT CACATGGATG AAGAATGGGC AGCTTGTCCC TTCCCACAGC 
AACAAGGAGA AGACGGCTCA GCCCAATGGA GACTGGACAT ACCAGACAGT CTCCTACCTA 
GCCCTAACCC CTTCCTACGG GGACGTCTAC ACCTGCGTGG TTCAGCACAG CGGGACCTCT 
GAGCCCATCC GAGGGGACTG GACACCTGGG CTGTCCCCCA TCCAGACAGT GAAGGTCTCT 
GTGTCTGCAG CCACCCTGGG CCTGGGCTTC ATCATCTTCT GTGTTGGCTT CTTCAGATGG 
CGCAAGTCTC ATTCCTCCAG CTACACTCCT CTCTCTGGAT CCACCTACCC GGAAGGACAG 
CATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034517.2
CDS	209..994
Translation	MAALWLLLLVLSLDCMGAGGFVAHVESTCVLDDAGTPQDFTYCVSFNKDLLACWDPDVGKIVPCEFGVLYPWAENFSRILNKEESLLQRLQNGLLDCASHTQPFWNALTHRTRAPSVRVAQTTPFNTREPVMLACYVWGFYPADVTITWMKNGQLVPSHSNKEKTAQPNGDWTYQTVSYLALTPSYGDVYTCVVQHSGTSEPIRGDWTPGLSPIQTVKVSVSAATLGLGFIIFCVGFFRWRKSHSSSYTPLSGSTYPEGQH

Target ORF information:

RefSeq Version	NM_010387.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus histocompatibility 2, class II, locus Mb1 (H2-DMb1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010387.3

ORF Insert Sequence:

ATGGCTGCAC TCTGGCTGCT GCTGCTGGTC CTCAGTCTGG ACTGTATGGG GGCAGGTGGC 
TTTGTGGCTC ATGTGGAAAG CACGTGCGTG CTGGATGATG CTGGGACCCC ACAGGACTTC 
ACATACTGTG TTTCCTTCAA CAAAGATCTG CTGGCCTGCT GGGATCCAGA TGTGGGAAAA 
ATAGTCCCCT GTGAATTTGG GGTGCTGTAT CCATGGGCCG AAAATTTTTC AAGGATCCTC 
AACAAAGAAG AGAGCCTTCT CCAGCGTTTG CAAAACGGGC TTCTGGACTG TGCCTCCCAC 
ACCCAGCCCT TCTGGAATGC GCTGACCCAC AGAACGAGAG CGCCATCTGT CCGAGTAGCC 
CAAACCACAC CTTTTAACAC AAGGGAGCCG GTGATGCTGG CCTGCTACGT CTGGGGCTTC 
TATCCAGCGG ATGTGACCAT CACATGGATG AAGAATGGGC AGCTTGTCCC TTCCCACAGC 
AACAAGGAGA AGACGGCTCA GCCCAATGGA GACTGGACAT ACCAGACAGT CTCCTACCTA 
GCCCTAACCC CTTCCTACGG GGACGTCTAC ACCTGCGTGG TTCAGCACAG CGGGACCTCT 
GAGCCCATCC GAGGGGACTG GACACCTGGG CTGTCCCCCA TCCAGACAGT GAAGGTCTCT 
GTGTCTGCAG CCACCCTGGG CCTGGGCTTC ATCATCTTCT GTGTTGGCTT CTTCAGATGG 
CGCAAGTCTC ATTCCTCCAG CTACACTCCT CTCTCTGGAT CCACCTACCC GGAAGGACAG 
CATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The QTL within the H2 Complex Involved in the Control of Tuberculosis Infection in Mice Is the Classical Class II H2-Ab1 Gene.
PLoS genetics11(11)e1005672(2015 Nov)
Logunova N,Korotetskaya M,Polshakov V,Apt A

H2-Mbeta 1 and H2-Mbeta 2 heterodimers equally promote clip removal in I-A(q) molecules from autoimmune-prone DBA/1 mice.
The Journal of biological chemistry276(14)11086-91(2001 Apr)
Walter W,Scheuer C,Loos M,Reichert TE,Maeurer MJ

MHC class II antigen presentation pathway in murine tumours: tumour evasion from immunosurveillance?
British journal of cancer83(9)1192-201(2000 Nov)
Walter W,Lingnau K,Schmitt E,Loos M,Maeurer MJ

The mouse as a model for the effects of MHC genes on human disease.
Immunology today21(7)328-32(2000 Jul)
Allcock RJ,Martin AM,Price P

Coordinate regulation of B cell differentiation by the transcription factors EBF and E2A.
Immunity11(1)21-31(1999 Jul)
O'Riordan M,Grosschedl R