MAT1A cDNA ORF clone, Mus musculus(House mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	MAT1A
Entrez Gene ID	11720
Full Name	methionine adenosyltransferase I, alpha
Synonyms	AI046368,AdoMet,Ams,MAT,MATA1,SAMS,SAMS1
General protein information	Preferred Names methionine adenosyltransferase I, alpha Names S-adenosylmethionine synthase isoform type-1 S-adenosylmethionine synthase adoMet synthetase 1
Gene Type	protein-coding
Organism	Mus musculus(House mouse)
Genome	Chromosome: 14 Map Location: 14\|14 B
Summary	This gene encodes a member of the AdoMet synthase family. Methionine adenosyltransferase is a product of this gene (the alpha form) and the beta form and catalyzes the formation of S-adenosylmethionine from methionine and ATP.[provided by RefSeq, Jan 2013].

mRNA and Protein(s)

mRNA	Protein	Name
NM_133653.3	NP_598414.1	S-adenosylmethionine synthase isoform type-1
XM_006518450.2	XP_006518513.1	S-adenosylmethionine synthase isoform X1
XM_006518450.3	XP_006518513.1	S-adenosylmethionine synthase isoform X1
XM_006518450.1	XP_006518513.1	S-adenosylmethionine synthase isoform type-1 isoform X1

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	mat1a	NP_956165.1
Arabidopsis thaliana (thale cress)	SAM-2	NP_001078345.1
Arabidopsis thaliana (thale cress)	SAM1	NP_171751.1
Xenopus tropicalis (tropical clawed frog)	mat1a	NP_001106625.1
Oryza sativa (rice)	Os05g0135700	NP_001054575.1
Homo sapiens (human)	MAT1A	NP_000420.1
Macaca mulatta (Rhesus monkey)	MAT1A	XP_001087977.1
Gallus gallus (chicken)	MAT1A	NP_001186448.1
Oryza sativa (rice)	Os01g0293000	NP_001042794.1
Pan troglodytes (chimpanzee)	MAT1A	XP_507874.2
Canis lupus familiaris (dog)	MAT1A	XP_851933.1
Bos taurus (cattle)	MAT1A	NP_001039962.1
Rattus norvegicus (Norway rat)	Mat1a	NP_036992.2
Mus musculus (house mouse)	Mat1a	NP_598414.1

Gene Ontology
Bibliography

Related articles in PubMed

Alterations of Methionine Metabolism as Potential Targets for the Prevention and Therapy of Hepatocellular Carcinoma.
Pascale RM, Peitta G, Simile MM, Feo F
Medicina (Kaunas, Lithuania)55(6)(2019 Jun)

Methionine adenosyltransferase 2A regulates mouse zygotic genome activation and morula to blastocyst transition†.
Sun H, Kang J, Su J, Zhang J, Zhang L, Liu X, Zhang J, Wang F, Lu Z, Xing X, Chen H, Zhang Y
Biology of reproduction100(3)601-617(2019 03)

A novel mechanism of the M1-M2 methionine adenosyltransferase switch-mediated hepatocellular carcinoma metastasis.
Wang R, Jin Y, Yao XH, Fan W, Zhang J, Cao Y, Li J
Molecular carcinogenesis57(9)1201-1212(2018 09)

Deregulated methionine adenosyltransferase α1, c-Myc, and Maf proteins together promote cholangiocarcinoma growth in mice and humans(‡).
Yang H, Liu T, Wang J, Li TW, Fan W, Peng H, Krishnan A, Gores GJ, Mato JM, Lu SC
Hepatology (Baltimore, Md.)64(2)439-55(2016 08)

Fibroblast growth factor receptor-mediated activation of AKT-β-catenin-CBP pathway regulates survival and proliferation of murine hepatoblasts and hepatic tumor initiating stem cells.
Mavila N, James D, Utley S, Cu N, Coblens O, Mak K, Rountree CB, Kahn M, Wang KS
PloS one7(11)e50401(2012)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following MAT1A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MAT1A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu10036	NM_133653.3 Latest version!	Mus musculus methionine adenosyltransferase I, alpha (Mat1a), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$223.30 $319.00
OMu10036	XM_006518450.3 Latest version!	Mus musculus methionine adenosyltransferase I, alpha (Mat1a), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$223.30 $319.00
View Old Accession Versions >>
OMu10036	XM_006518450.2	Mus musculus methionine adenosyltransferase I, alpha (Mat1a), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$223.30 $319.00
OMu10036	XM_006518450.1	Mus musculus methionine adenosyltransferase I, alpha (Mat1a), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MAT1A ( XM_006518450.1 ) cDNA ORF clone, Mus musculus(House mouse) -> XP_006518513.1 Mus musculus methionine adenosyltransferase I, alpha (Mat1a), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu10036
Clone ID Related Accession (Same CDS sequence)	NM_133653.3 , XM_006518450.2 , XM_006518450.3 , XM_006518450.1
Accession Version	XM_006518450.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1191bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1423324800000
Organism	Mus musculus(House mouse)
Product	S-adenosylmethionine synthase isoform type-1 isoform X1
Comment

ATGAATGGAC CTGTGGATGG CTTGTGTGAC CATTCTCTAA GTGAAGAGGG AGCCTTCATG 
TTCACATCAG AATCTGTAGG AGAGGGGCAT CCAGATAAGA TCTGTGACCA GATTAGTGAT 
GCGGTGCTGG ATGCTCACCT CAAGCAAGAC CCCAATGCCA AGGTGGCCTG TGAGACAGTG 
TGCAAGACAG GTATGGTGCT ACTGTGTGGG GAGATCACCT CAGTGGCCAT GGTTGATTAC 
CAGCGGGTGG TGAGAGACAC CATCAAGCAC ATTGGCTATG ACGACTCTGC CAAGGGCTTT 
GACTTCAAGA CTTGCAATGT GCTAGTGGCT CTGGAGCAAC AGTCCCCAGA TATTGCCCAA 
TGTGTCCACC TAGACAGAAA TGAAGAGGAT GTTGGTGCAG GAGATCAGGG TCTGATGTTT 
GGCTATGCTA CTGATGAGAC CGAGGAATGC ATGCCCCTTA CCATCGTGCT CGCTCACAAA 
CTCAACACCC GGATAGCAGA TCTGAGGCGC TCTGGTGTCC TTCCCTGGCT GAGACCTGAT 
TCTAAGACTC AGGTAACAGT TCAGTACATG CAGGATAATG GTGCAGTCAT CCCTGTGCGC 
ATCCACACCA TCGTCATCTC TGTGCAACAC AATGAAGACA TCACACTGGA GGCCATGCAA 
GAGGCCCTGA AAGAGCAGGT GATCAAAGCT GTGGTGCCAG CCAAGTACCT GGATGAAGAT 
ACTGTTTACC ACCTGCAGCC AAGTGGGCGG TTTGTTATTG GAGGCCCCCA GGGGGATGCA 
GGTGTCACGG GCCGCAAGAT TATTGTGGAC ACATACGGAG GCTGGGGTGC CCATGGTGGT 
GGTGCCTTCT CTGGAAAGGA CTACACCAAG GTGGACCGCT CAGCAGCTTA TGCTGCCCGC 
TGGGTGGCCA AGTCCCTGGT AAAGGCTGGG CTCTGCCGGA GAGTGCTTGT TCAGGTGTCC 
TATGCCATTG GTGTGGCAGA ACCTCTGTCC ATTTCCATCT TCACCTACGG GACCTCCAAT 
AAGACTGAGC GGGAGCTGCT AGAGGTGGTG AACAAGAACT TTGACCTTCG GCCTGGTGTT 
ATTGTCAGGG ACTTGGATCT GAAAAAACCC ATCTACCAGA AGACTGCGTG CTACGGCCAT 
TTCGGGAGAA GCGAGTTTCC CTGGGAGGTC CCCAAGAAGC TTGTGTTTTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006518513.1
Translation	MNGPVDGLCDHSLSEEGAFMFTSESVGEGHPDKICDQISDAVLDAHLKQDPNAKVACETVCKTGMVLLCGEITSVAMVDYQRVVRDTIKHIGYDDSAKGFDFKTCNVLVALEQQSPDIAQCVHLDRNEEDVGAGDQGLMFGYATDETEECMPLTIVLAHKLNTRIADLRRSGVLPWLRPDSKTQVTVQYMQDNGAVIPVRIHTIVISVQHNEDITLEAMQEALKEQVIKAVVPAKYLDEDTVYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKAGLCRRVLVQVSYAIGVAEPLSISIFTYGTSNKTERELLEVVNKNFDLRPGVIVRDLDLKKPIYQKTACYGHFGRSEFPWEVPKKLVF

Target ORF information:

RefSeq Version	XM_006518450.1
Organism	Mus musculus(House mouse)
Definition	Mus musculus methionine adenosyltransferase I, alpha (Mat1a), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006518450.1

ORF Insert Sequence:

ATGAATGGAC CTGTGGATGG CTTGTGTGAC CATTCTCTAA GTGAAGAGGG AGCCTTCATG 
TTCACATCAG AATCTGTAGG AGAGGGGCAT CCAGATAAGA TCTGTGACCA GATTAGTGAT 
GCGGTGCTGG ATGCTCACCT CAAGCAAGAC CCCAATGCCA AGGTGGCCTG TGAGACAGTG 
TGCAAGACAG GTATGGTGCT ACTGTGTGGG GAGATCACCT CAGTGGCCAT GGTTGATTAC 
CAGCGGGTGG TGAGAGACAC CATCAAGCAC ATTGGCTATG ACGACTCTGC CAAGGGCTTT 
GACTTCAAGA CTTGCAATGT GCTAGTGGCT CTGGAGCAAC AGTCCCCAGA TATTGCCCAA 
TGTGTCCACC TAGACAGAAA TGAAGAGGAT GTTGGTGCAG GAGATCAGGG TCTGATGTTT 
GGCTATGCTA CTGATGAGAC CGAGGAATGC ATGCCCCTTA CCATCGTGCT CGCTCACAAA 
CTCAACACCC GGATAGCAGA TCTGAGGCGC TCTGGTGTCC TTCCCTGGCT GAGACCTGAT 
TCTAAGACTC AGGTAACAGT TCAGTACATG CAGGATAATG GTGCAGTCAT CCCTGTGCGC 
ATCCACACCA TCGTCATCTC TGTGCAACAC AATGAAGACA TCACACTGGA GGCCATGCAA 
GAGGCCCTGA AAGAGCAGGT GATCAAAGCT GTGGTGCCAG CCAAGTACCT GGATGAAGAT 
ACTGTTTACC ACCTGCAGCC AAGTGGGCGG TTTGTTATTG GAGGCCCCCA GGGGGATGCA 
GGTGTCACGG GCCGCAAGAT TATTGTGGAC ACATACGGAG GCTGGGGTGC CCATGGTGGT 
GGTGCCTTCT CTGGAAAGGA CTACACCAAG GTGGACCGCT CAGCAGCTTA TGCTGCCCGC 
TGGGTGGCCA AGTCCCTGGT AAAGGCTGGG CTCTGCCGGA GAGTGCTTGT TCAGGTGTCC 
TATGCCATTG GTGTGGCAGA ACCTCTGTCC ATTTCCATCT TCACCTACGG GACCTCCAAT 
AAGACTGAGC GGGAGCTGCT AGAGGTGGTG AACAAGAACT TTGACCTTCG GCCTGGTGTT 
ATTGTCAGGG ACTTGGATCT GAAAAAACCC ATCTACCAGA AGACTGCGTG CTACGGCCAT 
TTCGGGAGAA GCGAGTTTCC CTGGGAGGTC CCCAAGAAGC TTGTGTTTTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MAT1A ( NM_133653.3 ) cDNA ORF clone, Mus musculus(House mouse) -> NP_598414.1 Mus musculus methionine adenosyltransferase I, alpha (Mat1a), mRNA.

Price & Availability↑

CloneID	OMu10036
Clone ID Related Accession (Same CDS sequence)	NM_133653.3 , XM_006518450.2 , XM_006518450.3 , XM_006518450.1
Accession Version	NM_133653.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1191bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577116800000
Organism	Mus musculus(house mouse)
Product	S-adenosylmethionine synthase isoform type-1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC154597.2, BB871001.1, AK153832.1, BB807316.1 and AC124400.4. On Jan 30, 2013 this sequence version replaced NM_133653.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: L13622.1, BC011211.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849377 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAATGGAC CTGTGGATGG CTTGTGTGAC CATTCTCTAA GTGAAGAGGG AGCCTTCATG 
TTCACATCAG AATCTGTAGG AGAGGGGCAT CCAGATAAGA TCTGTGACCA GATTAGTGAT 
GCGGTGCTGG ATGCTCACCT CAAGCAAGAC CCCAATGCCA AGGTGGCCTG TGAGACAGTG 
TGCAAGACAG GTATGGTGCT ACTGTGTGGG GAGATCACCT CAGTGGCCAT GGTTGATTAC 
CAGCGGGTGG TGAGAGACAC CATCAAGCAC ATTGGCTATG ACGACTCTGC CAAGGGCTTT 
GACTTCAAGA CTTGCAATGT GCTAGTGGCT CTGGAGCAAC AGTCCCCAGA TATTGCCCAA 
TGTGTCCACC TAGACAGAAA TGAAGAGGAT GTTGGTGCAG GAGATCAGGG TCTGATGTTT 
GGCTATGCTA CTGATGAGAC CGAGGAATGC ATGCCCCTTA CCATCGTGCT CGCTCACAAA 
CTCAACACCC GGATAGCAGA TCTGAGGCGC TCTGGTGTCC TTCCCTGGCT GAGACCTGAT 
TCTAAGACTC AGGTAACAGT TCAGTACATG CAGGATAATG GTGCAGTCAT CCCTGTGCGC 
ATCCACACCA TCGTCATCTC TGTGCAACAC AATGAAGACA TCACACTGGA GGCCATGCAA 
GAGGCCCTGA AAGAGCAGGT GATCAAAGCT GTGGTGCCAG CCAAGTACCT GGATGAAGAT 
ACTGTTTACC ACCTGCAGCC AAGTGGGCGG TTTGTTATTG GAGGCCCCCA GGGGGATGCA 
GGTGTCACGG GCCGCAAGAT TATTGTGGAC ACATACGGAG GCTGGGGTGC CCATGGTGGT 
GGTGCCTTCT CTGGAAAGGA CTACACCAAG GTGGACCGCT CAGCAGCTTA TGCTGCCCGC 
TGGGTGGCCA AGTCCCTGGT AAAGGCTGGG CTCTGCCGGA GAGTGCTTGT TCAGGTGTCC 
TATGCCATTG GTGTGGCAGA ACCTCTGTCC ATTTCCATCT TCACCTACGG GACCTCCAAT 
AAGACTGAGC GGGAGCTGCT AGAGGTGGTG AACAAGAACT TTGACCTTCG GCCTGGTGTT 
ATTGTCAGGG ACTTGGATCT GAAAAAACCC ATCTACCAGA AGACTGCGTG CTACGGCCAT 
TTCGGGAGAA GCGAGTTTCC CTGGGAGGTC CCCAAGAAGC TTGTGTTTTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_598414.1
CDS	473..1663
Translation	MNGPVDGLCDHSLSEEGAFMFTSESVGEGHPDKICDQISDAVLDAHLKQDPNAKVACETVCKTGMVLLCGEITSVAMVDYQRVVRDTIKHIGYDDSAKGFDFKTCNVLVALEQQSPDIAQCVHLDRNEEDVGAGDQGLMFGYATDETEECMPLTIVLAHKLNTRIADLRRSGVLPWLRPDSKTQVTVQYMQDNGAVIPVRIHTIVISVQHNEDITLEAMQEALKEQVIKAVVPAKYLDEDTVYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKAGLCRRVLVQVSYAIGVAEPLSISIFTYGTSNKTERELLEVVNKNFDLRPGVIVRDLDLKKPIYQKTACYGHFGRSEFPWEVPKKLVF

Target ORF information:

RefSeq Version	NM_133653.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus methionine adenosyltransferase I, alpha (Mat1a), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133653.3

ORF Insert Sequence:

ATGAATGGAC CTGTGGATGG CTTGTGTGAC CATTCTCTAA GTGAAGAGGG AGCCTTCATG 
TTCACATCAG AATCTGTAGG AGAGGGGCAT CCAGATAAGA TCTGTGACCA GATTAGTGAT 
GCGGTGCTGG ATGCTCACCT CAAGCAAGAC CCCAATGCCA AGGTGGCCTG TGAGACAGTG 
TGCAAGACAG GTATGGTGCT ACTGTGTGGG GAGATCACCT CAGTGGCCAT GGTTGATTAC 
CAGCGGGTGG TGAGAGACAC CATCAAGCAC ATTGGCTATG ACGACTCTGC CAAGGGCTTT 
GACTTCAAGA CTTGCAATGT GCTAGTGGCT CTGGAGCAAC AGTCCCCAGA TATTGCCCAA 
TGTGTCCACC TAGACAGAAA TGAAGAGGAT GTTGGTGCAG GAGATCAGGG TCTGATGTTT 
GGCTATGCTA CTGATGAGAC CGAGGAATGC ATGCCCCTTA CCATCGTGCT CGCTCACAAA 
CTCAACACCC GGATAGCAGA TCTGAGGCGC TCTGGTGTCC TTCCCTGGCT GAGACCTGAT 
TCTAAGACTC AGGTAACAGT TCAGTACATG CAGGATAATG GTGCAGTCAT CCCTGTGCGC 
ATCCACACCA TCGTCATCTC TGTGCAACAC AATGAAGACA TCACACTGGA GGCCATGCAA 
GAGGCCCTGA AAGAGCAGGT GATCAAAGCT GTGGTGCCAG CCAAGTACCT GGATGAAGAT 
ACTGTTTACC ACCTGCAGCC AAGTGGGCGG TTTGTTATTG GAGGCCCCCA GGGGGATGCA 
GGTGTCACGG GCCGCAAGAT TATTGTGGAC ACATACGGAG GCTGGGGTGC CCATGGTGGT 
GGTGCCTTCT CTGGAAAGGA CTACACCAAG GTGGACCGCT CAGCAGCTTA TGCTGCCCGC 
TGGGTGGCCA AGTCCCTGGT AAAGGCTGGG CTCTGCCGGA GAGTGCTTGT TCAGGTGTCC 
TATGCCATTG GTGTGGCAGA ACCTCTGTCC ATTTCCATCT TCACCTACGG GACCTCCAAT 
AAGACTGAGC GGGAGCTGCT AGAGGTGGTG AACAAGAACT TTGACCTTCG GCCTGGTGTT 
ATTGTCAGGG ACTTGGATCT GAAAAAACCC ATCTACCAGA AGACTGCGTG CTACGGCCAT 
TTCGGGAGAA GCGAGTTTCC CTGGGAGGTC CCCAAGAAGC TTGTGTTTTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MAT1A ( XM_006518450.2 ) cDNA ORF clone, Mus musculus(House mouse) -> XP_006518513.1 Mus musculus methionine adenosyltransferase I, alpha (Mat1a), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu10036
Clone ID Related Accession (Same CDS sequence)	NM_133653.3 , XM_006518450.2 , XM_006518450.3 , XM_006518450.1
Accession Version	XM_006518450.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1191bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1466438400000
Organism	Mus musculus(house mouse)
Product	S-adenosylmethionine synthase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000080.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006518450.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAATGGAC CTGTGGATGG CTTGTGTGAC CATTCTCTAA GTGAAGAGGG AGCCTTCATG 
TTCACATCAG AATCTGTAGG AGAGGGGCAT CCAGATAAGA TCTGTGACCA GATTAGTGAT 
GCGGTGCTGG ATGCTCACCT CAAGCAAGAC CCCAATGCCA AGGTGGCCTG TGAGACAGTG 
TGCAAGACAG GTATGGTGCT ACTGTGTGGG GAGATCACCT CAGTGGCCAT GGTTGATTAC 
CAGCGGGTGG TGAGAGACAC CATCAAGCAC ATTGGCTATG ACGACTCTGC CAAGGGCTTT 
GACTTCAAGA CTTGCAATGT GCTAGTGGCT CTGGAGCAAC AGTCCCCAGA TATTGCCCAA 
TGTGTCCACC TAGACAGAAA TGAAGAGGAT GTTGGTGCAG GAGATCAGGG TCTGATGTTT 
GGCTATGCTA CTGATGAGAC CGAGGAATGC ATGCCCCTTA CCATCGTGCT CGCTCACAAA 
CTCAACACCC GGATAGCAGA TCTGAGGCGC TCTGGTGTCC TTCCCTGGCT GAGACCTGAT 
TCTAAGACTC AGGTAACAGT TCAGTACATG CAGGATAATG GTGCAGTCAT CCCTGTGCGC 
ATCCACACCA TCGTCATCTC TGTGCAACAC AATGAAGACA TCACACTGGA GGCCATGCAA 
GAGGCCCTGA AAGAGCAGGT GATCAAAGCT GTGGTGCCAG CCAAGTACCT GGATGAAGAT 
ACTGTTTACC ACCTGCAGCC AAGTGGGCGG TTTGTTATTG GAGGCCCCCA GGGGGATGCA 
GGTGTCACGG GCCGCAAGAT TATTGTGGAC ACATACGGAG GCTGGGGTGC CCATGGTGGT 
GGTGCCTTCT CTGGAAAGGA CTACACCAAG GTGGACCGCT CAGCAGCTTA TGCTGCCCGC 
TGGGTGGCCA AGTCCCTGGT AAAGGCTGGG CTCTGCCGGA GAGTGCTTGT TCAGGTGTCC 
TATGCCATTG GTGTGGCAGA ACCTCTGTCC ATTTCCATCT TCACCTACGG GACCTCCAAT 
AAGACTGAGC GGGAGCTGCT AGAGGTGGTG AACAAGAACT TTGACCTTCG GCCTGGTGTT 
ATTGTCAGGG ACTTGGATCT GAAAAAACCC ATCTACCAGA AGACTGCGTG CTACGGCCAT 
TTCGGGAGAA GCGAGTTTCC CTGGGAGGTC CCCAAGAAGC TTGTGTTTTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006518513.1
CDS	333..1523
Translation	MNGPVDGLCDHSLSEEGAFMFTSESVGEGHPDKICDQISDAVLDAHLKQDPNAKVACETVCKTGMVLLCGEITSVAMVDYQRVVRDTIKHIGYDDSAKGFDFKTCNVLVALEQQSPDIAQCVHLDRNEEDVGAGDQGLMFGYATDETEECMPLTIVLAHKLNTRIADLRRSGVLPWLRPDSKTQVTVQYMQDNGAVIPVRIHTIVISVQHNEDITLEAMQEALKEQVIKAVVPAKYLDEDTVYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKAGLCRRVLVQVSYAIGVAEPLSISIFTYGTSNKTERELLEVVNKNFDLRPGVIVRDLDLKKPIYQKTACYGHFGRSEFPWEVPKKLVF

Target ORF information:

RefSeq Version	XM_006518450.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus methionine adenosyltransferase I, alpha (Mat1a), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006518450.2

ORF Insert Sequence:

ATGAATGGAC CTGTGGATGG CTTGTGTGAC CATTCTCTAA GTGAAGAGGG AGCCTTCATG 
TTCACATCAG AATCTGTAGG AGAGGGGCAT CCAGATAAGA TCTGTGACCA GATTAGTGAT 
GCGGTGCTGG ATGCTCACCT CAAGCAAGAC CCCAATGCCA AGGTGGCCTG TGAGACAGTG 
TGCAAGACAG GTATGGTGCT ACTGTGTGGG GAGATCACCT CAGTGGCCAT GGTTGATTAC 
CAGCGGGTGG TGAGAGACAC CATCAAGCAC ATTGGCTATG ACGACTCTGC CAAGGGCTTT 
GACTTCAAGA CTTGCAATGT GCTAGTGGCT CTGGAGCAAC AGTCCCCAGA TATTGCCCAA 
TGTGTCCACC TAGACAGAAA TGAAGAGGAT GTTGGTGCAG GAGATCAGGG TCTGATGTTT 
GGCTATGCTA CTGATGAGAC CGAGGAATGC ATGCCCCTTA CCATCGTGCT CGCTCACAAA 
CTCAACACCC GGATAGCAGA TCTGAGGCGC TCTGGTGTCC TTCCCTGGCT GAGACCTGAT 
TCTAAGACTC AGGTAACAGT TCAGTACATG CAGGATAATG GTGCAGTCAT CCCTGTGCGC 
ATCCACACCA TCGTCATCTC TGTGCAACAC AATGAAGACA TCACACTGGA GGCCATGCAA 
GAGGCCCTGA AAGAGCAGGT GATCAAAGCT GTGGTGCCAG CCAAGTACCT GGATGAAGAT 
ACTGTTTACC ACCTGCAGCC AAGTGGGCGG TTTGTTATTG GAGGCCCCCA GGGGGATGCA 
GGTGTCACGG GCCGCAAGAT TATTGTGGAC ACATACGGAG GCTGGGGTGC CCATGGTGGT 
GGTGCCTTCT CTGGAAAGGA CTACACCAAG GTGGACCGCT CAGCAGCTTA TGCTGCCCGC 
TGGGTGGCCA AGTCCCTGGT AAAGGCTGGG CTCTGCCGGA GAGTGCTTGT TCAGGTGTCC 
TATGCCATTG GTGTGGCAGA ACCTCTGTCC ATTTCCATCT TCACCTACGG GACCTCCAAT 
AAGACTGAGC GGGAGCTGCT AGAGGTGGTG AACAAGAACT TTGACCTTCG GCCTGGTGTT 
ATTGTCAGGG ACTTGGATCT GAAAAAACCC ATCTACCAGA AGACTGCGTG CTACGGCCAT 
TTCGGGAGAA GCGAGTTTCC CTGGGAGGTC CCCAAGAAGC TTGTGTTTTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MAT1A ( XM_006518450.3 ) cDNA ORF clone, Mus musculus(House mouse) -> XP_006518513.1 Mus musculus methionine adenosyltransferase I, alpha (Mat1a), transcript variant X1, mRNA.

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CloneID	OMu10036
Clone ID Related Accession (Same CDS sequence)	NM_133653.3 , XM_006518450.2 , XM_006518450.3 , XM_006518450.1
Accession Version	XM_006518450.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1191bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1565107200000
Organism	Mus musculus(house mouse)
Product	S-adenosylmethionine synthase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000080.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006518450.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAATGGAC CTGTGGATGG CTTGTGTGAC CATTCTCTAA GTGAAGAGGG AGCCTTCATG 
TTCACATCAG AATCTGTAGG AGAGGGGCAT CCAGATAAGA TCTGTGACCA GATTAGTGAT 
GCGGTGCTGG ATGCTCACCT CAAGCAAGAC CCCAATGCCA AGGTGGCCTG TGAGACAGTG 
TGCAAGACAG GTATGGTGCT ACTGTGTGGG GAGATCACCT CAGTGGCCAT GGTTGATTAC 
CAGCGGGTGG TGAGAGACAC CATCAAGCAC ATTGGCTATG ACGACTCTGC CAAGGGCTTT 
GACTTCAAGA CTTGCAATGT GCTAGTGGCT CTGGAGCAAC AGTCCCCAGA TATTGCCCAA 
TGTGTCCACC TAGACAGAAA TGAAGAGGAT GTTGGTGCAG GAGATCAGGG TCTGATGTTT 
GGCTATGCTA CTGATGAGAC CGAGGAATGC ATGCCCCTTA CCATCGTGCT CGCTCACAAA 
CTCAACACCC GGATAGCAGA TCTGAGGCGC TCTGGTGTCC TTCCCTGGCT GAGACCTGAT 
TCTAAGACTC AGGTAACAGT TCAGTACATG CAGGATAATG GTGCAGTCAT CCCTGTGCGC 
ATCCACACCA TCGTCATCTC TGTGCAACAC AATGAAGACA TCACACTGGA GGCCATGCAA 
GAGGCCCTGA AAGAGCAGGT GATCAAAGCT GTGGTGCCAG CCAAGTACCT GGATGAAGAT 
ACTGTTTACC ACCTGCAGCC AAGTGGGCGG TTTGTTATTG GAGGCCCCCA GGGGGATGCA 
GGTGTCACGG GCCGCAAGAT TATTGTGGAC ACATACGGAG GCTGGGGTGC CCATGGTGGT 
GGTGCCTTCT CTGGAAAGGA CTACACCAAG GTGGACCGCT CAGCAGCTTA TGCTGCCCGC 
TGGGTGGCCA AGTCCCTGGT AAAGGCTGGG CTCTGCCGGA GAGTGCTTGT TCAGGTGTCC 
TATGCCATTG GTGTGGCAGA ACCTCTGTCC ATTTCCATCT TCACCTACGG GACCTCCAAT 
AAGACTGAGC GGGAGCTGCT AGAGGTGGTG AACAAGAACT TTGACCTTCG GCCTGGTGTT 
ATTGTCAGGG ACTTGGATCT GAAAAAACCC ATCTACCAGA AGACTGCGTG CTACGGCCAT 
TTCGGGAGAA GCGAGTTTCC CTGGGAGGTC CCCAAGAAGC TTGTGTTTTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006518513.1
CDS	329..1519
Translation	MNGPVDGLCDHSLSEEGAFMFTSESVGEGHPDKICDQISDAVLDAHLKQDPNAKVACETVCKTGMVLLCGEITSVAMVDYQRVVRDTIKHIGYDDSAKGFDFKTCNVLVALEQQSPDIAQCVHLDRNEEDVGAGDQGLMFGYATDETEECMPLTIVLAHKLNTRIADLRRSGVLPWLRPDSKTQVTVQYMQDNGAVIPVRIHTIVISVQHNEDITLEAMQEALKEQVIKAVVPAKYLDEDTVYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKAGLCRRVLVQVSYAIGVAEPLSISIFTYGTSNKTERELLEVVNKNFDLRPGVIVRDLDLKKPIYQKTACYGHFGRSEFPWEVPKKLVF

Target ORF information:

RefSeq Version	XM_006518450.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus methionine adenosyltransferase I, alpha (Mat1a), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006518450.3

ORF Insert Sequence:

ATGAATGGAC CTGTGGATGG CTTGTGTGAC CATTCTCTAA GTGAAGAGGG AGCCTTCATG 
TTCACATCAG AATCTGTAGG AGAGGGGCAT CCAGATAAGA TCTGTGACCA GATTAGTGAT 
GCGGTGCTGG ATGCTCACCT CAAGCAAGAC CCCAATGCCA AGGTGGCCTG TGAGACAGTG 
TGCAAGACAG GTATGGTGCT ACTGTGTGGG GAGATCACCT CAGTGGCCAT GGTTGATTAC 
CAGCGGGTGG TGAGAGACAC CATCAAGCAC ATTGGCTATG ACGACTCTGC CAAGGGCTTT 
GACTTCAAGA CTTGCAATGT GCTAGTGGCT CTGGAGCAAC AGTCCCCAGA TATTGCCCAA 
TGTGTCCACC TAGACAGAAA TGAAGAGGAT GTTGGTGCAG GAGATCAGGG TCTGATGTTT 
GGCTATGCTA CTGATGAGAC CGAGGAATGC ATGCCCCTTA CCATCGTGCT CGCTCACAAA 
CTCAACACCC GGATAGCAGA TCTGAGGCGC TCTGGTGTCC TTCCCTGGCT GAGACCTGAT 
TCTAAGACTC AGGTAACAGT TCAGTACATG CAGGATAATG GTGCAGTCAT CCCTGTGCGC 
ATCCACACCA TCGTCATCTC TGTGCAACAC AATGAAGACA TCACACTGGA GGCCATGCAA 
GAGGCCCTGA AAGAGCAGGT GATCAAAGCT GTGGTGCCAG CCAAGTACCT GGATGAAGAT 
ACTGTTTACC ACCTGCAGCC AAGTGGGCGG TTTGTTATTG GAGGCCCCCA GGGGGATGCA 
GGTGTCACGG GCCGCAAGAT TATTGTGGAC ACATACGGAG GCTGGGGTGC CCATGGTGGT 
GGTGCCTTCT CTGGAAAGGA CTACACCAAG GTGGACCGCT CAGCAGCTTA TGCTGCCCGC 
TGGGTGGCCA AGTCCCTGGT AAAGGCTGGG CTCTGCCGGA GAGTGCTTGT TCAGGTGTCC 
TATGCCATTG GTGTGGCAGA ACCTCTGTCC ATTTCCATCT TCACCTACGG GACCTCCAAT 
AAGACTGAGC GGGAGCTGCT AGAGGTGGTG AACAAGAACT TTGACCTTCG GCCTGGTGTT 
ATTGTCAGGG ACTTGGATCT GAAAAAACCC ATCTACCAGA AGACTGCGTG CTACGGCCAT 
TTCGGGAGAA GCGAGTTTCC CTGGGAGGTC CCCAAGAAGC TTGTGTTTTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Alterations of Methionine Metabolism as Potential Targets for the Prevention and Therapy of Hepatocellular Carcinoma.
Medicina (Kaunas, Lithuania)55(6)(2019 Jun)
Pascale RM,Peitta G,Simile MM,Feo F

Methionine adenosyltransferase 2A regulates mouse zygotic genome activation and morula to blastocyst transition†.
Biology of reproduction100(3)601-617(2019 03)
Sun H,Kang J,Su J,Zhang J,Zhang L,Liu X,Zhang J,Wang F,Lu Z,Xing X,Chen H,Zhang Y

A novel mechanism of the M1-M2 methionine adenosyltransferase switch-mediated hepatocellular carcinoma metastasis.
Molecular carcinogenesis57(9)1201-1212(2018 09)
Wang R,Jin Y,Yao XH,Fan W,Zhang J,Cao Y,Li J

Deregulated methionine adenosyltransferase α1, c-Myc, and Maf proteins together promote cholangiocarcinoma growth in mice and humans(‡).
Hepatology (Baltimore, Md.)64(2)439-55(2016 08)
Yang H,Liu T,Wang J,Li TW,Fan W,Peng H,Krishnan A,Gores GJ,Mato JM,Lu SC

Fibroblast growth factor receptor-mediated activation of AKT-β-catenin-CBP pathway regulates survival and proliferation of murine hepatoblasts and hepatic tumor initiating stem cells.
PloS one7(11)e50401(2012)
Mavila N,James D,Utley S,Cu N,Coblens O,Mak K,Rountree CB,Kahn M,Wang KS

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MAT1A cDNA ORF clone, Mus musculus(House mouse)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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