HTRA3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HTRA3
Entrez Gene ID	94031
Full Name	HtrA serine peptidase 3
Synonyms	Prsp,Tasp
General protein information	Preferred Names HtrA serine peptidase 3 Names serine protease HTRA3 high-temperature requirement factor A3 pregnancy-related serine protease probable serine protease HTRA3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4p16.1
Disorder MIM:	608785

mRNA and Protein(s)

mRNA	Protein	Name
NM_053044.4	NP_444272.1	serine protease HTRA3 isoform 1 precursor
NM_001297559.2	NP_001284488.1	serine protease HTRA3 isoform 2 precursor
NM_001297559.1	NP_001284488.1	serine protease HTRA3 isoform 2 precursor
XM_011513596.2	XP_011511898.1	serine protease HTRA3 isoform X1
XM_011513596.3	XP_011511898.1	serine protease HTRA3 isoform X1
NM_053044.5	NP_444272.1	serine protease HTRA3 isoform 1 precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Htra3	NP_084403.2
Canis lupus familiaris (dog)	HTRA3	XP_005618790.1
Gallus gallus (chicken)	HTRA3	XP_420813.3
Homo sapiens (human)	HTRA3	NP_444272.1
Pan troglodytes (chimpanzee)	HTRA3	XP_517597.3
Macaca mulatta (Rhesus monkey)	HTRA3	XP_002804039.1
Rattus norvegicus (Norway rat)	Htra3	NP_001257956.1
Danio rerio (zebrafish)	LOC573378	XP_692974.6
Bos taurus (cattle)	HTRA3	XP_002688528.2
Xenopus tropicalis (tropical clawed frog)	htra3	XP_002938688.1

Gene Ontology
Bibliography

Related articles in PubMed

Long intergenic non‑coding RNA 00467 promotes lung adenocarcinoma proliferation, migration and invasion by binding with EZH2 and repressing HTRA3 expression.
Wang X, Liu H, Shen K, Pan X, Wei Y, Lv T, Song Y
Molecular medicine reports20(1)640-654(2019 Jul)

Hypoxia is involved in the reduction of HtrA3 in patients with endometrial hyperplasia and cancer.
Lv Q, Yang B, Ning C, Xie B, Nie G, Chen X, Chen Q
Biochemical and biophysical research communications503(4)2918-2923(2018 09)

Peptide selectivity between the PDZ domains of human pregnancy-related serine proteases (HtrA1, HtrA2, HtrA3, and HtrA4) can be reshaped by different halogen probes.
Sun ML, Sun LM, Wang YQ
Journal of molecular recognition : JMR31(6)e2698(2018 06)

HtrA3 is a cellular partner of cytoskeleton proteins and TCP1α chaperonin.
Wenta T, Zurawa-Janicka D, Rychlowski M, Jarzab M, Glaza P, Lipinska A, Bienkowska-Szewczyk K, Herman-Antosiewicz A, Skorko-Glonek J, Lipinska B
Journal of proteomics17788-111(2018 04)

Paeoniflorin suppresses pancreatic cancer cell growth by upregulating HTRA3 expression.
Li Y, Gong L, Qi R, Sun Q, Xia X, He H, Ren J, Zhu O, Zhuo D
Drug design, development and therapy112481-2491(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following HTRA3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HTRA3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

Online Only Promotion

Up to 50% OFF! Starting
from $49/clone

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu28801	NM_001297559.2 Latest version!	Homo sapiens HtrA serine peptidase 3 (HTRA3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OHu74609	XM_011513596.3 Latest version!	Homo sapiens HtrA serine peptidase 3 (HTRA3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OHu28769	NM_053044.5 Latest version!	Homo sapiens HtrA serine peptidase 3 (HTRA3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$223.30 $319.00
View Old Accession Versions >>
OHu28801	NM_001297559.1	Homo sapiens HtrA serine peptidase 3 (HTRA3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OHu74609	XM_011513596.2	Homo sapiens HtrA serine peptidase 3 (HTRA3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OHu28769	NM_053044.4	Homo sapiens HtrA serine peptidase 3 (HTRA3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$223.30 $319.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HTRA3 ( NM_001297559.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001284488.1 Homo sapiens HtrA serine peptidase 3 (HTRA3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu28801
Clone ID Related Accession (Same CDS sequence)	NM_001297559.2 , NM_001297559.1
Accession Version	NM_001297559.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1074bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577980800000
Organism	Homo sapiens(human)
Product	serine protease HTRA3 isoform 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC113611.3, DN996853.1, AY280666.1 and AW072765.1. On May 31, 2019 this sequence version replaced NM_001297559.1. Transcript Variant: This variant (2) lacks several exons, and contains an alternate 3'-terminal exon, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY280666.1, ERR279835.9424.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCAGGCGC GAGCGCTGCT CCTGGCCGCG TTGGCCGCGC TGGCGCTGGC CCGGGAGCCC 
CCTGCGGCGC CGTGTCCCGC GCGCTGCGAC GTGTCGCGGT GTCCCAGCCC CCGCTGCCCC 
GGCGGCTACG TGCCCGACCT CTGCAACTGC TGCCTGGTGT GCGCCGCCAG CGAGGGCGAG 
CCCTGTGGCG GCCCTCTGGA CTCGCCTTGC GGCGAGAGCC TGGAGTGCGT GCGCGGCCTA 
TGCCGCTGCC GCTGGTCGCA CGCCGTGTGT GGCACCGACG GGCACACCTA TGCCAACGTG 
TGCGCGCTGC AGGCGGCCAG CCGCCGCGCG CTGCAGCTCT CCGGGACGCC CGTGCGCCAG 
CTGCAGAAGG GCGCCTGCCC GTTGGGTCTC CACCAGCTGA GCAGCCCGCG CTACAAGTTC 
AACTTCATTG CTGACGTGGT GGAGAAGATC GCACCAGCCG TGGTCCACAT AGAGCTCTTC 
CTGAGACACC CGCTGTTTGG CCGCAACGTG CCCCTGTCCA GCGGTTCTGG CTTCATCATG 
TCAGAGGCCG GCCTGATCAT CACCAATGCC CACGTGGTGT CCAGCAACAG TGCTGCCCCG 
GGCAGGCAGC AGCTCAAGGT GCAGCTACAG AATGGGGACT CCTATGAGGC CACCATCAAA 
GACATCGACA AGAAGTCGGA CATTGCCACC ATCAAGATCC ATCCCAAGAA AAAGCTCCCT 
GTGTTGTTGC TGGGTCACTC GGCCGACCTG CGGCCTGGGG AGTTTGTGGT GGCCATCGGC 
AGTCCCTTCG CCCTACAGAA CACAGTGACA ACGGGCATCG TCAGCACTGC CCAGCGGGAG 
GGCAGGGAGC TGGGCCTCCG GGACTCCGAC ATGGACTACA TCCAGACGGA TGCCATCATC 
AACTACGGGA ACTCCGGGGG ACCACTGGTG AACCTGGATG GCGAGGTCAT TGGCATCAAC 
ACGCTCAAGG TCACGGCTGG CATCTCCTTT GCCATCCCCT CAGACCGCAT CACACGGTTC 
CTCACAGAGT TCCAAGACAA GCAGATCAAA GCCCCCTCAC TGGCAGTTCA TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001284488.1
CDS	216..1289
Translation	MQARALLLAALAALALAREPPAAPCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAASEGEPCGGPLDSPCGESLECVRGLCRCRWSHAVCGTDGHTYANVCALQAASRRALQLSGTPVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKAPSLAVH

Target ORF information:

RefSeq Version	NM_001297559.2
Organism	Homo sapiens(human)
Definition	Homo sapiens HtrA serine peptidase 3 (HTRA3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001297559.2

ORF Insert Sequence:

ATGCAGGCGC GAGCGCTGCT CCTGGCCGCG TTGGCCGCGC TGGCGCTGGC CCGGGAGCCC 
CCTGCGGCGC CGTGTCCCGC GCGCTGCGAC GTGTCGCGGT GTCCCAGCCC CCGCTGCCCC 
GGCGGCTACG TGCCCGACCT CTGCAACTGC TGCCTGGTGT GCGCCGCCAG CGAGGGCGAG 
CCCTGTGGCG GCCCTCTGGA CTCGCCTTGC GGCGAGAGCC TGGAGTGCGT GCGCGGCCTA 
TGCCGCTGCC GCTGGTCGCA CGCCGTGTGT GGCACCGACG GGCACACCTA TGCCAACGTG 
TGCGCGCTGC AGGCGGCCAG CCGCCGCGCG CTGCAGCTCT CCGGGACGCC CGTGCGCCAG 
CTGCAGAAGG GCGCCTGCCC GTTGGGTCTC CACCAGCTGA GCAGCCCGCG CTACAAGTTC 
AACTTCATTG CTGACGTGGT GGAGAAGATC GCACCAGCCG TGGTCCACAT AGAGCTCTTC 
CTGAGACACC CGCTGTTTGG CCGCAACGTG CCCCTGTCCA GCGGTTCTGG CTTCATCATG 
TCAGAGGCCG GCCTGATCAT CACCAATGCC CACGTGGTGT CCAGCAACAG TGCTGCCCCG 
GGCAGGCAGC AGCTCAAGGT GCAGCTACAG AATGGGGACT CCTATGAGGC CACCATCAAA 
GACATCGACA AGAAGTCGGA CATTGCCACC ATCAAGATCC ATCCCAAGAA AAAGCTCCCT 
GTGTTGTTGC TGGGTCACTC GGCCGACCTG CGGCCTGGGG AGTTTGTGGT GGCCATCGGC 
AGTCCCTTCG CCCTACAGAA CACAGTGACA ACGGGCATCG TCAGCACTGC CCAGCGGGAG 
GGCAGGGAGC TGGGCCTCCG GGACTCCGAC ATGGACTACA TCCAGACGGA TGCCATCATC 
AACTACGGGA ACTCCGGGGG ACCACTGGTG AACCTGGATG GCGAGGTCAT TGGCATCAAC 
ACGCTCAAGG TCACGGCTGG CATCTCCTTT GCCATCCCCT CAGACCGCAT CACACGGTTC 
CTCACAGAGT TCCAAGACAA GCAGATCAAA GCCCCCTCAC TGGCAGTTCA TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HTRA3 ( NM_001297559.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001284488.1 Homo sapiens HtrA serine peptidase 3 (HTRA3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu28801
Clone ID Related Accession (Same CDS sequence)	NM_001297559.2 , NM_001297559.1
Accession Version	NM_001297559.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1074bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1550851200000
Organism	Homo sapiens(human)
Product	serine protease HTRA3 isoform 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DN996853.1, AY280666.1 and AW072765.1. On Jul 4, 2014 this sequence version replaced XM_005248040.1. Transcript Variant: This variant (2) lacks several exons, and contains an alternate 3'-terminal exon, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279835.9424.1, AY280666.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCAGGCGC GAGCGCTGCT CCTGGCCGCG TTGGCCGCGC TGGCGCTGGC CCGGGAGCCC 
CCTGCGGCGC CGTGTCCCGC GCGCTGCGAC GTGTCGCGGT GTCCCAGCCC CCGCTGCCCC 
GGCGGCTACG TGCCCGACCT CTGCAACTGC TGCCTGGTGT GCGCCGCCAG CGAGGGCGAG 
CCCTGTGGCG GCCCTCTGGA CTCGCCTTGC GGCGAGAGCC TGGAGTGCGT GCGCGGCCTA 
TGCCGCTGCC GCTGGTCGCA CGCCGTGTGT GGCACCGACG GGCACACCTA TGCCAACGTG 
TGCGCGCTGC AGGCGGCCAG CCGCCGCGCG CTGCAGCTCT CCGGGACGCC CGTGCGCCAG 
CTGCAGAAGG GCGCCTGCCC GTTGGGTCTC CACCAGCTGA GCAGCCCGCG CTACAAGTTC 
AACTTCATTG CTGACGTGGT GGAGAAGATC GCACCAGCCG TGGTCCACAT AGAGCTCTTC 
CTGAGACACC CGCTGTTTGG CCGCAACGTG CCCCTGTCCA GCGGTTCTGG CTTCATCATG 
TCAGAGGCCG GCCTGATCAT CACCAATGCC CACGTGGTGT CCAGCAACAG TGCTGCCCCG 
GGCAGGCAGC AGCTCAAGGT GCAGCTACAG AATGGGGACT CCTATGAGGC CACCATCAAA 
GACATCGACA AGAAGTCGGA CATTGCCACC ATCAAGATCC ATCCCAAGAA AAAGCTCCCT 
GTGTTGTTGC TGGGTCACTC GGCCGACCTG CGGCCTGGGG AGTTTGTGGT GGCCATCGGC 
AGTCCCTTCG CCCTACAGAA CACAGTGACA ACGGGCATCG TCAGCACTGC CCAGCGGGAG 
GGCAGGGAGC TGGGCCTCCG GGACTCCGAC ATGGACTACA TCCAGACGGA TGCCATCATC 
AACTACGGGA ACTCCGGGGG ACCACTGGTG AACCTGGATG GCGAGGTCAT TGGCATCAAC 
ACGCTCAAGG TCACGGCTGG CATCTCCTTT GCCATCCCCT CAGACCGCAT CACACGGTTC 
CTCACAGAGT TCCAAGACAA GCAGATCAAA GCCCCCTCAC TGGCAGTTCA TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001284488.1
CDS	205..1278
Translation	MQARALLLAALAALALAREPPAAPCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAASEGEPCGGPLDSPCGESLECVRGLCRCRWSHAVCGTDGHTYANVCALQAASRRALQLSGTPVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKAPSLAVH

Target ORF information:

RefSeq Version	NM_001297559.1
Organism	Homo sapiens(human)
Definition	Homo sapiens HtrA serine peptidase 3 (HTRA3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001297559.1

ORF Insert Sequence:

ATGCAGGCGC GAGCGCTGCT CCTGGCCGCG TTGGCCGCGC TGGCGCTGGC CCGGGAGCCC 
CCTGCGGCGC CGTGTCCCGC GCGCTGCGAC GTGTCGCGGT GTCCCAGCCC CCGCTGCCCC 
GGCGGCTACG TGCCCGACCT CTGCAACTGC TGCCTGGTGT GCGCCGCCAG CGAGGGCGAG 
CCCTGTGGCG GCCCTCTGGA CTCGCCTTGC GGCGAGAGCC TGGAGTGCGT GCGCGGCCTA 
TGCCGCTGCC GCTGGTCGCA CGCCGTGTGT GGCACCGACG GGCACACCTA TGCCAACGTG 
TGCGCGCTGC AGGCGGCCAG CCGCCGCGCG CTGCAGCTCT CCGGGACGCC CGTGCGCCAG 
CTGCAGAAGG GCGCCTGCCC GTTGGGTCTC CACCAGCTGA GCAGCCCGCG CTACAAGTTC 
AACTTCATTG CTGACGTGGT GGAGAAGATC GCACCAGCCG TGGTCCACAT AGAGCTCTTC 
CTGAGACACC CGCTGTTTGG CCGCAACGTG CCCCTGTCCA GCGGTTCTGG CTTCATCATG 
TCAGAGGCCG GCCTGATCAT CACCAATGCC CACGTGGTGT CCAGCAACAG TGCTGCCCCG 
GGCAGGCAGC AGCTCAAGGT GCAGCTACAG AATGGGGACT CCTATGAGGC CACCATCAAA 
GACATCGACA AGAAGTCGGA CATTGCCACC ATCAAGATCC ATCCCAAGAA AAAGCTCCCT 
GTGTTGTTGC TGGGTCACTC GGCCGACCTG CGGCCTGGGG AGTTTGTGGT GGCCATCGGC 
AGTCCCTTCG CCCTACAGAA CACAGTGACA ACGGGCATCG TCAGCACTGC CCAGCGGGAG 
GGCAGGGAGC TGGGCCTCCG GGACTCCGAC ATGGACTACA TCCAGACGGA TGCCATCATC 
AACTACGGGA ACTCCGGGGG ACCACTGGTG AACCTGGATG GCGAGGTCAT TGGCATCAAC 
ACGCTCAAGG TCACGGCTGG CATCTCCTTT GCCATCCCCT CAGACCGCAT CACACGGTTC 
CTCACAGAGT TCCAAGACAA GCAGATCAAA GCCCCCTCAC TGGCAGTTCA TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HTRA3 ( XM_011513596.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011511898.1 Homo sapiens HtrA serine peptidase 3 (HTRA3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu74609
Clone ID Related Accession (Same CDS sequence)	XM_011513596.2 , XM_011513596.3
Accession Version	XM_011513596.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1122bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1465056000000
Organism	Homo sapiens(human)
Product	serine protease HTRA3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011513596.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCAGGCGC GAGCGCTGCT CCTGGCCGCG TTGGCCGCGC TGGCGCTGGC CCGGGAGCCC 
CCTGCGGCGC CGTGTCCCGC GCGCTGCGAC GTGTCGCGGT GTCCCAGCCC CCGCTGCCCC 
GGCGGCTACG TGCCCGACCT CTGCAACTGC TGCCTGGTGT GCGCCGCCAG CGAGGGCGAG 
CCCTGTGGCG GCCCTCTGGA CTCGCCTTGC GGCGAGAGCC TGGAGTGCGT GCGCGGCCTA 
TGCCGCTGCC GCTGGTCGCA CGCCGTGTGT GGCACCGACG GGCACACCTA TGCCAACGTG 
TGCGCGCTGC AGGCGGCCAG CCGCCGCGCG CTGCAGCTCT CCGGGACGCC CGTGCGCCAG 
CTGCAGAAGG GCGCCTGCCC GTTGGGTCTC CACCAGCTGA GCAGCCCGCG CTACAAGTTC 
AACTTCATTG CTGACGTGGT GGAGAAGATC GCACCAGCCG TGGTCCACAT AGAGCTCTTC 
CTGAGACACC CGCTGTTTGG CCGCAACGTG CCCCTGTCCA GCGGTTCTGG CTTCATCATG 
TCAGAGGCCG GCCTGATCAT CACCAATGCC CACGTGGTGT CCAGCAACAG TGCTGCCCCG 
GGCAGGCAGC AGCTCAAGGT GCAGCTACAG AATGGGGACT CCTATGAGGC CACCATCAAA 
GACATCGACA AGAAGTCGGA CATTGCCACC ATCAAGATCC ATCCCAAGAA AAAGCTCCCT 
GTGTTGTTGC TGGGTCACTC GGCCGACCTG CGGCCTGGGG AGTTTGTGGT GGCCATCGGC 
AGTCCCTTCG CCCTACAGAA CACAGTGACA ACGGGCATCG TCAGCACTGC CCAGCGGGAG 
GGCAGGGAGC TGGGCCTCCG GGACTCCGAC ATGGACTACA TCCAGACGGA TGCCATCATC 
AACTACGGGA ACTCCGGGGG ACCACTGGTG AACCTGGATG GCGAGGTCAT TGGCATCAAC 
ACGCTCAAGG TCACGGCTGG CATCTCCTTT GCCATCCCCT CAGACCGCAT CACACGGTTC 
CTCACAGAGT TCCAAGACAA GCAGATCAAA GCCAAGCACA TGGACCCCAG TGCAGCCAAG 
GCTGGTGCCA TGAGGGCTGG TCACATGAAG AGCTGCTGTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011511898.1
CDS	213..1334
Translation	MQARALLLAALAALALAREPPAAPCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAASEGEPCGGPLDSPCGESLECVRGLCRCRWSHAVCGTDGHTYANVCALQAASRRALQLSGTPVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKAKHMDPSAAKAGAMRAGHMKSCC

Target ORF information:

RefSeq Version	XM_011513596.2
Organism	Homo sapiens(human)
Definition	Homo sapiens HtrA serine peptidase 3 (HTRA3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011513596.2

ORF Insert Sequence:

ATGCAGGCGC GAGCGCTGCT CCTGGCCGCG TTGGCCGCGC TGGCGCTGGC CCGGGAGCCC 
CCTGCGGCGC CGTGTCCCGC GCGCTGCGAC GTGTCGCGGT GTCCCAGCCC CCGCTGCCCC 
GGCGGCTACG TGCCCGACCT CTGCAACTGC TGCCTGGTGT GCGCCGCCAG CGAGGGCGAG 
CCCTGTGGCG GCCCTCTGGA CTCGCCTTGC GGCGAGAGCC TGGAGTGCGT GCGCGGCCTA 
TGCCGCTGCC GCTGGTCGCA CGCCGTGTGT GGCACCGACG GGCACACCTA TGCCAACGTG 
TGCGCGCTGC AGGCGGCCAG CCGCCGCGCG CTGCAGCTCT CCGGGACGCC CGTGCGCCAG 
CTGCAGAAGG GCGCCTGCCC GTTGGGTCTC CACCAGCTGA GCAGCCCGCG CTACAAGTTC 
AACTTCATTG CTGACGTGGT GGAGAAGATC GCACCAGCCG TGGTCCACAT AGAGCTCTTC 
CTGAGACACC CGCTGTTTGG CCGCAACGTG CCCCTGTCCA GCGGTTCTGG CTTCATCATG 
TCAGAGGCCG GCCTGATCAT CACCAATGCC CACGTGGTGT CCAGCAACAG TGCTGCCCCG 
GGCAGGCAGC AGCTCAAGGT GCAGCTACAG AATGGGGACT CCTATGAGGC CACCATCAAA 
GACATCGACA AGAAGTCGGA CATTGCCACC ATCAAGATCC ATCCCAAGAA AAAGCTCCCT 
GTGTTGTTGC TGGGTCACTC GGCCGACCTG CGGCCTGGGG AGTTTGTGGT GGCCATCGGC 
AGTCCCTTCG CCCTACAGAA CACAGTGACA ACGGGCATCG TCAGCACTGC CCAGCGGGAG 
GGCAGGGAGC TGGGCCTCCG GGACTCCGAC ATGGACTACA TCCAGACGGA TGCCATCATC 
AACTACGGGA ACTCCGGGGG ACCACTGGTG AACCTGGATG GCGAGGTCAT TGGCATCAAC 
ACGCTCAAGG TCACGGCTGG CATCTCCTTT GCCATCCCCT CAGACCGCAT CACACGGTTC 
CTCACAGAGT TCCAAGACAA GCAGATCAAA GCCAAGCACA TGGACCCCAG TGCAGCCAAG 
GCTGGTGCCA TGAGGGCTGG TCACATGAAG AGCTGCTGTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HTRA3 ( XM_011513596.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_011511898.1 Homo sapiens HtrA serine peptidase 3 (HTRA3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu74609
Clone ID Related Accession (Same CDS sequence)	XM_011513596.2 , XM_011513596.3
Accession Version	XM_011513596.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1122bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	serine protease HTRA3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011513596.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCAGGCGC GAGCGCTGCT CCTGGCCGCG TTGGCCGCGC TGGCGCTGGC CCGGGAGCCC 
CCTGCGGCGC CGTGTCCCGC GCGCTGCGAC GTGTCGCGGT GTCCCAGCCC CCGCTGCCCC 
GGCGGCTACG TGCCCGACCT CTGCAACTGC TGCCTGGTGT GCGCCGCCAG CGAGGGCGAG 
CCCTGTGGCG GCCCTCTGGA CTCGCCTTGC GGCGAGAGCC TGGAGTGCGT GCGCGGCCTA 
TGCCGCTGCC GCTGGTCGCA CGCCGTGTGT GGCACCGACG GGCACACCTA TGCCAACGTG 
TGCGCGCTGC AGGCGGCCAG CCGCCGCGCG CTGCAGCTCT CCGGGACGCC CGTGCGCCAG 
CTGCAGAAGG GCGCCTGCCC GTTGGGTCTC CACCAGCTGA GCAGCCCGCG CTACAAGTTC 
AACTTCATTG CTGACGTGGT GGAGAAGATC GCACCAGCCG TGGTCCACAT AGAGCTCTTC 
CTGAGACACC CGCTGTTTGG CCGCAACGTG CCCCTGTCCA GCGGTTCTGG CTTCATCATG 
TCAGAGGCCG GCCTGATCAT CACCAATGCC CACGTGGTGT CCAGCAACAG TGCTGCCCCG 
GGCAGGCAGC AGCTCAAGGT GCAGCTACAG AATGGGGACT CCTATGAGGC CACCATCAAA 
GACATCGACA AGAAGTCGGA CATTGCCACC ATCAAGATCC ATCCCAAGAA AAAGCTCCCT 
GTGTTGTTGC TGGGTCACTC GGCCGACCTG CGGCCTGGGG AGTTTGTGGT GGCCATCGGC 
AGTCCCTTCG CCCTACAGAA CACAGTGACA ACGGGCATCG TCAGCACTGC CCAGCGGGAG 
GGCAGGGAGC TGGGCCTCCG GGACTCCGAC ATGGACTACA TCCAGACGGA TGCCATCATC 
AACTACGGGA ACTCCGGGGG ACCACTGGTG AACCTGGATG GCGAGGTCAT TGGCATCAAC 
ACGCTCAAGG TCACGGCTGG CATCTCCTTT GCCATCCCCT CAGACCGCAT CACACGGTTC 
CTCACAGAGT TCCAAGACAA GCAGATCAAA GCCAAGCACA TGGACCCCAG TGCAGCCAAG 
GCTGGTGCCA TGAGGGCTGG TCACATGAAG AGCTGCTGTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011511898.1
CDS	258..1379
Translation	MQARALLLAALAALALAREPPAAPCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAASEGEPCGGPLDSPCGESLECVRGLCRCRWSHAVCGTDGHTYANVCALQAASRRALQLSGTPVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKAKHMDPSAAKAGAMRAGHMKSCC

Target ORF information:

RefSeq Version	XM_011513596.3
Organism	Homo sapiens(human)
Definition	Homo sapiens HtrA serine peptidase 3 (HTRA3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011513596.3

ORF Insert Sequence:

ATGCAGGCGC GAGCGCTGCT CCTGGCCGCG TTGGCCGCGC TGGCGCTGGC CCGGGAGCCC 
CCTGCGGCGC CGTGTCCCGC GCGCTGCGAC GTGTCGCGGT GTCCCAGCCC CCGCTGCCCC 
GGCGGCTACG TGCCCGACCT CTGCAACTGC TGCCTGGTGT GCGCCGCCAG CGAGGGCGAG 
CCCTGTGGCG GCCCTCTGGA CTCGCCTTGC GGCGAGAGCC TGGAGTGCGT GCGCGGCCTA 
TGCCGCTGCC GCTGGTCGCA CGCCGTGTGT GGCACCGACG GGCACACCTA TGCCAACGTG 
TGCGCGCTGC AGGCGGCCAG CCGCCGCGCG CTGCAGCTCT CCGGGACGCC CGTGCGCCAG 
CTGCAGAAGG GCGCCTGCCC GTTGGGTCTC CACCAGCTGA GCAGCCCGCG CTACAAGTTC 
AACTTCATTG CTGACGTGGT GGAGAAGATC GCACCAGCCG TGGTCCACAT AGAGCTCTTC 
CTGAGACACC CGCTGTTTGG CCGCAACGTG CCCCTGTCCA GCGGTTCTGG CTTCATCATG 
TCAGAGGCCG GCCTGATCAT CACCAATGCC CACGTGGTGT CCAGCAACAG TGCTGCCCCG 
GGCAGGCAGC AGCTCAAGGT GCAGCTACAG AATGGGGACT CCTATGAGGC CACCATCAAA 
GACATCGACA AGAAGTCGGA CATTGCCACC ATCAAGATCC ATCCCAAGAA AAAGCTCCCT 
GTGTTGTTGC TGGGTCACTC GGCCGACCTG CGGCCTGGGG AGTTTGTGGT GGCCATCGGC 
AGTCCCTTCG CCCTACAGAA CACAGTGACA ACGGGCATCG TCAGCACTGC CCAGCGGGAG 
GGCAGGGAGC TGGGCCTCCG GGACTCCGAC ATGGACTACA TCCAGACGGA TGCCATCATC 
AACTACGGGA ACTCCGGGGG ACCACTGGTG AACCTGGATG GCGAGGTCAT TGGCATCAAC 
ACGCTCAAGG TCACGGCTGG CATCTCCTTT GCCATCCCCT CAGACCGCAT CACACGGTTC 
CTCACAGAGT TCCAAGACAA GCAGATCAAA GCCAAGCACA TGGACCCCAG TGCAGCCAAG 
GCTGGTGCCA TGAGGGCTGG TCACATGAAG AGCTGCTGTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HTRA3 ( NM_053044.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_444272.1 Homo sapiens HtrA serine peptidase 3 (HTRA3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu28769
Clone ID Related Accession (Same CDS sequence)	NM_053044.4 , NM_053044.5
Accession Version	NM_053044.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1362bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1509552000000
Organism	Homo sapiens(human)
Product	serine protease HTRA3 isoform 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC035717.1. On Jul 3, 2014 this sequence version replaced NM_053044.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC035717.1, AY280665.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCAGGCGC GAGCGCTGCT CCTGGCCGCG TTGGCCGCGC TGGCGCTGGC CCGGGAGCCC 
CCTGCGGCGC CGTGTCCCGC GCGCTGCGAC GTGTCGCGGT GTCCCAGCCC CCGCTGCCCC 
GGCGGCTACG TGCCCGACCT CTGCAACTGC TGCCTGGTGT GCGCCGCCAG CGAGGGCGAG 
CCCTGTGGCG GCCCTCTGGA CTCGCCTTGC GGCGAGAGCC TGGAGTGCGT GCGCGGCCTA 
TGCCGCTGCC GCTGGTCGCA CGCCGTGTGT GGCACCGACG GGCACACCTA TGCCAACGTG 
TGCGCGCTGC AGGCGGCCAG CCGCCGCGCG CTGCAGCTCT CCGGGACGCC CGTGCGCCAG 
CTGCAGAAGG GCGCCTGCCC GTTGGGTCTC CACCAGCTGA GCAGCCCGCG CTACAAGTTC 
AACTTCATTG CTGACGTGGT GGAGAAGATC GCACCAGCCG TGGTCCACAT AGAGCTCTTC 
CTGAGACACC CGCTGTTTGG CCGCAACGTG CCCCTGTCCA GCGGTTCTGG CTTCATCATG 
TCAGAGGCCG GCCTGATCAT CACCAATGCC CACGTGGTGT CCAGCAACAG TGCTGCCCCG 
GGCAGGCAGC AGCTCAAGGT GCAGCTACAG AATGGGGACT CCTATGAGGC CACCATCAAA 
GACATCGACA AGAAGTCGGA CATTGCCACC ATCAAGATCC ATCCCAAGAA AAAGCTCCCT 
GTGTTGTTGC TGGGTCACTC GGCCGACCTG CGGCCTGGGG AGTTTGTGGT GGCCATCGGC 
AGTCCCTTCG CCCTACAGAA CACAGTGACA ACGGGCATCG TCAGCACTGC CCAGCGGGAG 
GGCAGGGAGC TGGGCCTCCG GGACTCCGAC ATGGACTACA TCCAGACGGA TGCCATCATC 
AACTACGGGA ACTCCGGGGG ACCACTGGTG AACCTGGATG GCGAGGTCAT TGGCATCAAC 
ACGCTCAAGG TCACGGCTGG CATCTCCTTT GCCATCCCCT CAGACCGCAT CACACGGTTC 
CTCACAGAGT TCCAAGACAA GCAGATCAAA GACTGGAAGA AGCGCTTCAT CGGCATACGG 
ATGCGGACGA TCACACCAAG CCTGGTGGAT GAGCTGAAGG CCAGCAACCC GGACTTCCCA 
GAGGTCAGCA GTGGAATTTA TGTGCAAGAG GTTGCGCCGA ATTCACCTTC TCAGAGAGGC 
GGCATCCAAG ATGGTGACAT CATCGTCAAG GTCAACGGGC GTCCTCTAGT GGACTCGAGT 
GAGCTGCAGG AGGCCGTGCT GACCGAGTCT CCTCTCCTAC TGGAGGTGCG GCGGGGGAAC 
GACGACCTCC TCTTCAGCAT CGCACCTGAG GTGGTCATGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_444272.1
CDS	205..1566
Translation	MQARALLLAALAALALAREPPAAPCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAASEGEPCGGPLDSPCGESLECVRGLCRCRWSHAVCGTDGHTYANVCALQAASRRALQLSGTPVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKDWKKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSSELQEAVLTESPLLLEVRRGNDDLLFSIAPEVVM

Target ORF information:

RefSeq Version	NM_053044.4
Organism	Homo sapiens(human)
Definition	Homo sapiens HtrA serine peptidase 3 (HTRA3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053044.4

ORF Insert Sequence:

ATGCAGGCGC GAGCGCTGCT CCTGGCCGCG TTGGCCGCGC TGGCGCTGGC CCGGGAGCCC 
CCTGCGGCGC CGTGTCCCGC GCGCTGCGAC GTGTCGCGGT GTCCCAGCCC CCGCTGCCCC 
GGCGGCTACG TGCCCGACCT CTGCAACTGC TGCCTGGTGT GCGCCGCCAG CGAGGGCGAG 
CCCTGTGGCG GCCCTCTGGA CTCGCCTTGC GGCGAGAGCC TGGAGTGCGT GCGCGGCCTA 
TGCCGCTGCC GCTGGTCGCA CGCCGTGTGT GGCACCGACG GGCACACCTA TGCCAACGTG 
TGCGCGCTGC AGGCGGCCAG CCGCCGCGCG CTGCAGCTCT CCGGGACGCC CGTGCGCCAG 
CTGCAGAAGG GCGCCTGCCC GTTGGGTCTC CACCAGCTGA GCAGCCCGCG CTACAAGTTC 
AACTTCATTG CTGACGTGGT GGAGAAGATC GCACCAGCCG TGGTCCACAT AGAGCTCTTC 
CTGAGACACC CGCTGTTTGG CCGCAACGTG CCCCTGTCCA GCGGTTCTGG CTTCATCATG 
TCAGAGGCCG GCCTGATCAT CACCAATGCC CACGTGGTGT CCAGCAACAG TGCTGCCCCG 
GGCAGGCAGC AGCTCAAGGT GCAGCTACAG AATGGGGACT CCTATGAGGC CACCATCAAA 
GACATCGACA AGAAGTCGGA CATTGCCACC ATCAAGATCC ATCCCAAGAA AAAGCTCCCT 
GTGTTGTTGC TGGGTCACTC GGCCGACCTG CGGCCTGGGG AGTTTGTGGT GGCCATCGGC 
AGTCCCTTCG CCCTACAGAA CACAGTGACA ACGGGCATCG TCAGCACTGC CCAGCGGGAG 
GGCAGGGAGC TGGGCCTCCG GGACTCCGAC ATGGACTACA TCCAGACGGA TGCCATCATC 
AACTACGGGA ACTCCGGGGG ACCACTGGTG AACCTGGATG GCGAGGTCAT TGGCATCAAC 
ACGCTCAAGG TCACGGCTGG CATCTCCTTT GCCATCCCCT CAGACCGCAT CACACGGTTC 
CTCACAGAGT TCCAAGACAA GCAGATCAAA GACTGGAAGA AGCGCTTCAT CGGCATACGG 
ATGCGGACGA TCACACCAAG CCTGGTGGAT GAGCTGAAGG CCAGCAACCC GGACTTCCCA 
GAGGTCAGCA GTGGAATTTA TGTGCAAGAG GTTGCGCCGA ATTCACCTTC TCAGAGAGGC 
GGCATCCAAG ATGGTGACAT CATCGTCAAG GTCAACGGGC GTCCTCTAGT GGACTCGAGT 
GAGCTGCAGG AGGCCGTGCT GACCGAGTCT CCTCTCCTAC TGGAGGTGCG GCGGGGGAAC 
GACGACCTCC TCTTCAGCAT CGCACCTGAG GTGGTCATGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HTRA3 ( NM_053044.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_444272.1 Homo sapiens HtrA serine peptidase 3 (HTRA3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu28769
Clone ID Related Accession (Same CDS sequence)	NM_053044.4 , NM_053044.5
Accession Version	NM_053044.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1362bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577635200000
Organism	Homo sapiens(human)
Product	serine protease HTRA3 isoform 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC113611.3 and BC035717.1. On Nov 23, 2018 this sequence version replaced NM_053044.4. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279870.1338.1, BC034390.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000307358.7/ ENSP00000303766.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCAGGCGC GAGCGCTGCT CCTGGCCGCG TTGGCCGCGC TGGCGCTGGC CCGGGAGCCC 
CCTGCGGCGC CGTGTCCCGC GCGCTGCGAC GTGTCGCGGT GTCCCAGCCC CCGCTGCCCC 
GGCGGCTACG TGCCCGACCT CTGCAACTGC TGCCTGGTGT GCGCCGCCAG CGAGGGCGAG 
CCCTGTGGCG GCCCTCTGGA CTCGCCTTGC GGCGAGAGCC TGGAGTGCGT GCGCGGCCTA 
TGCCGCTGCC GCTGGTCGCA CGCCGTGTGT GGCACCGACG GGCACACCTA TGCCAACGTG 
TGCGCGCTGC AGGCGGCCAG CCGCCGCGCG CTGCAGCTCT CCGGGACGCC CGTGCGCCAG 
CTGCAGAAGG GCGCCTGCCC GTTGGGTCTC CACCAGCTGA GCAGCCCGCG CTACAAGTTC 
AACTTCATTG CTGACGTGGT GGAGAAGATC GCACCAGCCG TGGTCCACAT AGAGCTCTTC 
CTGAGACACC CGCTGTTTGG CCGCAACGTG CCCCTGTCCA GCGGTTCTGG CTTCATCATG 
TCAGAGGCCG GCCTGATCAT CACCAATGCC CACGTGGTGT CCAGCAACAG TGCTGCCCCG 
GGCAGGCAGC AGCTCAAGGT GCAGCTACAG AATGGGGACT CCTATGAGGC CACCATCAAA 
GACATCGACA AGAAGTCGGA CATTGCCACC ATCAAGATCC ATCCCAAGAA AAAGCTCCCT 
GTGTTGTTGC TGGGTCACTC GGCCGACCTG CGGCCTGGGG AGTTTGTGGT GGCCATCGGC 
AGTCCCTTCG CCCTACAGAA CACAGTGACA ACGGGCATCG TCAGCACTGC CCAGCGGGAG 
GGCAGGGAGC TGGGCCTCCG GGACTCCGAC ATGGACTACA TCCAGACGGA TGCCATCATC 
AACTACGGGA ACTCCGGGGG ACCACTGGTG AACCTGGATG GCGAGGTCAT TGGCATCAAC 
ACGCTCAAGG TCACGGCTGG CATCTCCTTT GCCATCCCCT CAGACCGCAT CACACGGTTC 
CTCACAGAGT TCCAAGACAA GCAGATCAAA GACTGGAAGA AGCGCTTCAT CGGCATACGG 
ATGCGGACGA TCACACCAAG CCTGGTGGAT GAGCTGAAGG CCAGCAACCC GGACTTCCCA 
GAGGTCAGCA GTGGAATTTA TGTGCAAGAG GTTGCGCCGA ATTCACCTTC TCAGAGAGGC 
GGCATCCAAG ATGGTGACAT CATCGTCAAG GTCAACGGGC GTCCTCTAGT GGACTCGAGT 
GAGCTGCAGG AGGCCGTGCT GACCGAGTCT CCTCTCCTAC TGGAGGTGCG GCGGGGGAAC 
GACGACCTCC TCTTCAGCAT CGCACCTGAG GTGGTCATGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_444272.1
CDS	216..1577
Translation	MQARALLLAALAALALAREPPAAPCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAASEGEPCGGPLDSPCGESLECVRGLCRCRWSHAVCGTDGHTYANVCALQAASRRALQLSGTPVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKDWKKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSSELQEAVLTESPLLLEVRRGNDDLLFSIAPEVVM

Target ORF information:

RefSeq Version	NM_053044.5
Organism	Homo sapiens(human)
Definition	Homo sapiens HtrA serine peptidase 3 (HTRA3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053044.5

ORF Insert Sequence:

ATGCAGGCGC GAGCGCTGCT CCTGGCCGCG TTGGCCGCGC TGGCGCTGGC CCGGGAGCCC 
CCTGCGGCGC CGTGTCCCGC GCGCTGCGAC GTGTCGCGGT GTCCCAGCCC CCGCTGCCCC 
GGCGGCTACG TGCCCGACCT CTGCAACTGC TGCCTGGTGT GCGCCGCCAG CGAGGGCGAG 
CCCTGTGGCG GCCCTCTGGA CTCGCCTTGC GGCGAGAGCC TGGAGTGCGT GCGCGGCCTA 
TGCCGCTGCC GCTGGTCGCA CGCCGTGTGT GGCACCGACG GGCACACCTA TGCCAACGTG 
TGCGCGCTGC AGGCGGCCAG CCGCCGCGCG CTGCAGCTCT CCGGGACGCC CGTGCGCCAG 
CTGCAGAAGG GCGCCTGCCC GTTGGGTCTC CACCAGCTGA GCAGCCCGCG CTACAAGTTC 
AACTTCATTG CTGACGTGGT GGAGAAGATC GCACCAGCCG TGGTCCACAT AGAGCTCTTC 
CTGAGACACC CGCTGTTTGG CCGCAACGTG CCCCTGTCCA GCGGTTCTGG CTTCATCATG 
TCAGAGGCCG GCCTGATCAT CACCAATGCC CACGTGGTGT CCAGCAACAG TGCTGCCCCG 
GGCAGGCAGC AGCTCAAGGT GCAGCTACAG AATGGGGACT CCTATGAGGC CACCATCAAA 
GACATCGACA AGAAGTCGGA CATTGCCACC ATCAAGATCC ATCCCAAGAA AAAGCTCCCT 
GTGTTGTTGC TGGGTCACTC GGCCGACCTG CGGCCTGGGG AGTTTGTGGT GGCCATCGGC 
AGTCCCTTCG CCCTACAGAA CACAGTGACA ACGGGCATCG TCAGCACTGC CCAGCGGGAG 
GGCAGGGAGC TGGGCCTCCG GGACTCCGAC ATGGACTACA TCCAGACGGA TGCCATCATC 
AACTACGGGA ACTCCGGGGG ACCACTGGTG AACCTGGATG GCGAGGTCAT TGGCATCAAC 
ACGCTCAAGG TCACGGCTGG CATCTCCTTT GCCATCCCCT CAGACCGCAT CACACGGTTC 
CTCACAGAGT TCCAAGACAA GCAGATCAAA GACTGGAAGA AGCGCTTCAT CGGCATACGG 
ATGCGGACGA TCACACCAAG CCTGGTGGAT GAGCTGAAGG CCAGCAACCC GGACTTCCCA 
GAGGTCAGCA GTGGAATTTA TGTGCAAGAG GTTGCGCCGA ATTCACCTTC TCAGAGAGGC 
GGCATCCAAG ATGGTGACAT CATCGTCAAG GTCAACGGGC GTCCTCTAGT GGACTCGAGT 
GAGCTGCAGG AGGCCGTGCT GACCGAGTCT CCTCTCCTAC TGGAGGTGCG GCGGGGGAAC 
GACGACCTCC TCTTCAGCAT CGCACCTGAG GTGGTCATGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Long intergenic non‑coding RNA 00467 promotes lung adenocarcinoma proliferation, migration and invasion by binding with EZH2 and repressing HTRA3 expression.
Molecular medicine reports20(1)640-654(2019 Jul)
Wang X,Liu H,Shen K,Pan X,Wei Y,Lv T,Song Y

Hypoxia is involved in the reduction of HtrA3 in patients with endometrial hyperplasia and cancer.
Biochemical and biophysical research communications503(4)2918-2923(2018 09)
Lv Q,Yang B,Ning C,Xie B,Nie G,Chen X,Chen Q

Peptide selectivity between the PDZ domains of human pregnancy-related serine proteases (HtrA1, HtrA2, HtrA3, and HtrA4) can be reshaped by different halogen probes.
Journal of molecular recognition : JMR31(6)e2698(2018 06)
Sun ML,Sun LM,Wang YQ

HtrA3 is a cellular partner of cytoskeleton proteins and TCP1α chaperonin.
Journal of proteomics17788-111(2018 04)
Wenta T,Zurawa-Janicka D,Rychlowski M,Jarzab M,Glaza P,Lipinska A,Bienkowska-Szewczyk K,Herman-Antosiewicz A,Skorko-Glonek J,Lipinska B

Paeoniflorin suppresses pancreatic cancer cell growth by upregulating HTRA3 expression.
Drug design, development and therapy112481-2491(2017)
Li Y,Gong L,Qi R,Sun Q,Xia X,He H,Ren J,Zhu O,Zhuo D

REQUEST A QUOTE

EMAIL

gene@genscript.com

PHONE

1-877-436-7274

ONLINE FORM

Online Quote Submission

ONLINE FORM

Online Quote Submission

HTRA3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

News & Blogs

REQUEST A QUOTE

EMAIL

PHONE

ONLINE FORM

ONLINE FORM