PIP4P1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PIP4P1
Entrez Gene ID	90809
Full Name	phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1
Synonyms	C14orf9,TMEM55B
General protein information	Preferred Names phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 Names type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase ptdIns-4,5-P(2) 4-phosphatase type I ptdIns-4,5-P2 4-Ptase I transmembrane protein 55B type 1 PtdIns-4,5-P2 4-Ptase type I PtdIns-4,5-P(2) 4-phosphatase type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 14 Map Location: 14q11.2
Summary	TMEM55B catalyzes the degradation of phosphatidylinositol 4,5-bisphosphate (PtdIns-4,5-P2) by removing the 4-phosphate (Ungewickell et al., 2005 [PubMed 16365287]).[supplied by OMIM, Mar 2008].
Disorder MIM:	609865

mRNA and Protein(s)

mRNA	Protein	Name
XM_024449740.1	XP_024305508.1	type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform X2
NM_144568.3	NP_653169.2	type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform 2
XM_024449739.1	XP_024305507.1	type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform X1
NM_001100814.2	NP_001094284.1	type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform 1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	TMEM55B	NP_001069827.1
Xenopus tropicalis (tropical clawed frog)	tmem55b	NP_001123847.1
Drosophila melanogaster (fruit fly)	CG6707	NP_648372.1
Caenorhabditis elegans (roundworm)	Y71H2AM.2	NP_497624.3
Canis lupus familiaris (dog)	TMEM55B	XP_539676.3
Mus musculus (house mouse)	Tmem55b	NP_001028443.1
Rattus norvegicus (Norway rat)	Tmem55b	NP_001014255.1
Danio rerio (zebrafish)	zgc:123304	NP_001032453.1
Danio rerio (zebrafish)	si:ch211-243g6.4	NP_001153393.1
Homo sapiens (human)	TMEM55B	NP_001094284.1
Pan troglodytes (chimpanzee)	TMEM55B	XP_520669.3
Macaca mulatta (Rhesus monkey)	TMEM55B	XP_002805012.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP006243	XP_316310.4

Gene Ontology
Bibliography

Related articles in PubMed

TMEM55B contributes to lysosomal homeostasis and amino acid-induced mTORC1 activation.
Hashimoto Y, Shirane M, Nakayama KI
Genes to cells : devoted to molecular & cellular mechanisms23(6)418-434(2018 Jun)

TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes.
Willett R, Martina JA, Zewe JP, Wills R, Hammond GRV, Puertollano R
Nature communications8(1)1580(2017 11)

Genetic analysis of the pathogenic molecular sub-phenotype interferon-alpha identifies multiple novel loci involved in systemic lupus erythematosus.
Kariuki SN, Ghodke-Puranik Y, Dorschner JM, Chrabot BS, Kelly JA, Tsao BP, Kimberly RP, Alarcón-Riquelme ME, Jacob CO, Criswell LA, Sivils KL, Langefeld CD, Harley JB, Skol AD, Niewold TB
Genes and immunity16(1)15-23(2015 Jan-Feb)

Transmembrane protein 55B is a novel regulator of cellular cholesterol metabolism.
Medina MW, Bauzon F, Naidoo D, Theusch E, Stevens K, Schilde J, Schubert C, Mangravite LM, Rudel LL, Temel RE, Runz H, Krauss RM
Arteriosclerosis, thrombosis, and vascular biology34(9)1917-23(2014 Sep)

Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis.
Zou J, Marjanovic J, Kisseleva MV, Wilson M, Majerus PW
Proceedings of the National Academy of Sciences of the United States of America104(43)16834-9(2007 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following PIP4P1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PIP4P1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu06109	NM_001100814.2 Latest version!	Homo sapiens phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 (PIP4P1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu103951	XM_024449739.1 Latest version!	Homo sapiens phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 (PIP4P1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu103952	XM_024449740.1 Latest version!	Homo sapiens phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 (PIP4P1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu06320	NM_144568.3 Latest version!	Homo sapiens phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 (PIP4P1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$216.30 $309.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PIP4P1 ( NM_001100814.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001094284.1 Homo sapiens phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 (PIP4P1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu06109
Clone ID Related Accession (Same CDS sequence)	NM_001100814.2
Accession Version	NM_001100814.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 855bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1544803200000
Organism	Homo sapiens(human)
Product	type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK314021.1, BX161490.1, BX248025.1 and CA430067.1. On Jan 15, 2014 this sequence version replaced NM_001100814.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: SRR1163655.642166.1, SRR1163658.323563.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCAG ATGGAGAGCG TTCCCCGCTG CTGTCTGAGC CCATCGACGG TGGCGCGGGC 
GGCAACGGTT TAGTGGGGCC CGGCGGGAGT GGGGCTGGGC CCGGGGGAGG CCTGACCCCC 
TCCGCACCAC CGTACGGAGC CGGTAAACAT GCCCCGCCCC AGGCATTTCC CCCGTTTCCC 
GAGGGGCATC CAGCCGTGTT GCCTGGGGAG GACCCACCCC CCTATTCACC CTTAACTAGC 
CCGGACAGTG GGAGTGCCCC TATGATCACC TGCCGAGTCT GCCAATCTCT CATCAACGTG 
GAAGGCAAGA TGCATCAGCA TGTAGTCAAA TGTGGTGTCT GCAATGAAGC CACCCCAATC 
AAGAATGCAC CCCCAGGGAA AAAATATGTT CGATGCCCCT GTAACTGTCT CCTTATCTGC 
AAAGTGACAT CCCAACGGAT TGCATGCCCT CGGCCCTACT GCAAAAGAAT CATCAACCTG 
GGGCCTGTGC ATCCCGGACC TCTGAGTCCA GAACCCCAAC CCATGGGTGT CAGGGTTATC 
TGTGGACATT GCAAGAATAC TTTTCTGTGG ACAGAGTTCA CAGACCGCAC TTTGGCACGT 
TGTCCTCACT GCAGGAAAGT GTCATCTATT GGGCGCAGAT ACCCACGTAA GAGATGTATC 
TGCTGCTTCT TGCTTGGCTT GCTTTTGGCA GTCACTGCCA CTGGCCTTGC CTTTGGCACA 
TGGAAGCATG CACGGCGATA TGGAGGCATC TATGCAGCCT GGGCATTTGT CATCCTGTTG 
GCTGTGCTGT GTTTGGGCCG GGCTCTTTAT TGGGCCTGTA TGAAGGTCAG CCACCCTGTC 
CAGAACTTCT CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001094284.1
CDS	288..1142
Translation	MAADGERSPLLSEPIDGGAGGNGLVGPGGSGAGPGGGLTPSAPPYGAGKHAPPQAFPPFPEGHPAVLPGEDPPPYSPLTSPDSGSAPMITCRVCQSLINVEGKMHQHVVKCGVCNEATPIKNAPPGKKYVRCPCNCLLICKVTSQRIACPRPYCKRIINLGPVHPGPLSPEPQPMGVRVICGHCKNTFLWTEFTDRTLARCPHCRKVSSIGRRYPRKRCICCFLLGLLLAVTATGLAFGTWKHARRYGGIYAAWAFVILLAVLCLGRALYWACMKVSHPVQNFS

Target ORF information:

RefSeq Version	NM_001100814.2
Organism	Homo sapiens(human)
Definition	Homo sapiens phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 (PIP4P1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001100814.2

ORF Insert Sequence:

ATGGCGGCAG ATGGAGAGCG TTCCCCGCTG CTGTCTGAGC CCATCGACGG TGGCGCGGGC 
GGCAACGGTT TAGTGGGGCC CGGCGGGAGT GGGGCTGGGC CCGGGGGAGG CCTGACCCCC 
TCCGCACCAC CGTACGGAGC CGGTAAACAT GCCCCGCCCC AGGCATTTCC CCCGTTTCCC 
GAGGGGCATC CAGCCGTGTT GCCTGGGGAG GACCCACCCC CCTATTCACC CTTAACTAGC 
CCGGACAGTG GGAGTGCCCC TATGATCACC TGCCGAGTCT GCCAATCTCT CATCAACGTG 
GAAGGCAAGA TGCATCAGCA TGTAGTCAAA TGTGGTGTCT GCAATGAAGC CACCCCAATC 
AAGAATGCAC CCCCAGGGAA AAAATATGTT CGATGCCCCT GTAACTGTCT CCTTATCTGC 
AAAGTGACAT CCCAACGGAT TGCATGCCCT CGGCCCTACT GCAAAAGAAT CATCAACCTG 
GGGCCTGTGC ATCCCGGACC TCTGAGTCCA GAACCCCAAC CCATGGGTGT CAGGGTTATC 
TGTGGACATT GCAAGAATAC TTTTCTGTGG ACAGAGTTCA CAGACCGCAC TTTGGCACGT 
TGTCCTCACT GCAGGAAAGT GTCATCTATT GGGCGCAGAT ACCCACGTAA GAGATGTATC 
TGCTGCTTCT TGCTTGGCTT GCTTTTGGCA GTCACTGCCA CTGGCCTTGC CTTTGGCACA 
TGGAAGCATG CACGGCGATA TGGAGGCATC TATGCAGCCT GGGCATTTGT CATCCTGTTG 
GCTGTGCTGT GTTTGGGCCG GGCTCTTTAT TGGGCCTGTA TGAAGGTCAG CCACCCTGTC 
CAGAACTTCT CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PIP4P1 ( XM_024449739.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024305507.1 Homo sapiens phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 (PIP4P1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu103951
Clone ID Related Accession (Same CDS sequence)	XM_024449739.1
Accession Version	XM_024449739.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 717bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000014.9) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGGCAG ATGGAGAGCG TTCCCCGCTG CTGTCTGAGC CCATCGACGG TGGCGCGGGC 
GGCAACGGTT TAGTGGGGCC CGGCGGGAGT GGGGCTGGGC CCGGGGGAGG CCTGACCCCC 
TCCGCACCAC CGTACGGAGC CGGTAAACAT GCCCCGCCCC AGGCATTTCC CCCGTTTCCC 
GAGGGGCATC CAGCCGTGTT GCCTGGGGAG GACCCACCCC CCTATTCACC CTTAACTAGC 
CCGGACAGTG GGAGTGCCCC TATGATCACC TGCCGAGTCT GCCAATCTCT CATCAACGTG 
GAAGGCAAGA TGCATCAGCA TGTAGTCAAA TGTGGTGTCT GCAATGAAGC CACCCCAATC 
AAGAATGCAC CCCCAGGGAA AAAATATGTT CGATGCCCCT GTAACTGTCT CCTTATCTGC 
AAAGTGACAT CCCAACGGAT TGCATGCCCT CGGCCCTACT GTGGACAGAG TTCACAGACC 
GCACTTTGGC ACGTTGTCCT CACTGCAGGA AAGTGTCATC TATTGGGCGC AGATACCCAC 
GTAAGAGATG TATCTGCTGC TTCTTGCTTG GCTTGCTTTT GGCAGTCACT GCCACTGGCC 
TTGCCTTTGG CACATGGAAG CATGCACGGC GATATGGAGG CATCTATGCA GCCTGGGCAT 
TTGTCATCCT GTTGGCTGTG CTGTGTTTGG GCCGGGCTCT TTATTGGGCC TGTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024305507.1
CDS	139..855
Translation	MAADGERSPLLSEPIDGGAGGNGLVGPGGSGAGPGGGLTPSAPPYGAGKHAPPQAFPPFPEGHPAVLPGEDPPPYSPLTSPDSGSAPMITCRVCQSLINVEGKMHQHVVKCGVCNEATPIKNAPPGKKYVRCPCNCLLICKVTSQRIACPRPYCGQSSQTALWHVVLTAGKCHLLGADTHVRDVSAASCLACFWQSLPLALPLAHGSMHGDMEASMQPGHLSSCWLCCVWAGLFIGPV

Target ORF information:

RefSeq Version	XM_024449739.1
Organism	Homo sapiens(human)
Definition	Homo sapiens phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 (PIP4P1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024449739.1

ORF Insert Sequence:

ATGGCGGCAG ATGGAGAGCG TTCCCCGCTG CTGTCTGAGC CCATCGACGG TGGCGCGGGC 
GGCAACGGTT TAGTGGGGCC CGGCGGGAGT GGGGCTGGGC CCGGGGGAGG CCTGACCCCC 
TCCGCACCAC CGTACGGAGC CGGTAAACAT GCCCCGCCCC AGGCATTTCC CCCGTTTCCC 
GAGGGGCATC CAGCCGTGTT GCCTGGGGAG GACCCACCCC CCTATTCACC CTTAACTAGC 
CCGGACAGTG GGAGTGCCCC TATGATCACC TGCCGAGTCT GCCAATCTCT CATCAACGTG 
GAAGGCAAGA TGCATCAGCA TGTAGTCAAA TGTGGTGTCT GCAATGAAGC CACCCCAATC 
AAGAATGCAC CCCCAGGGAA AAAATATGTT CGATGCCCCT GTAACTGTCT CCTTATCTGC 
AAAGTGACAT CCCAACGGAT TGCATGCCCT CGGCCCTACT GTGGACAGAG TTCACAGACC 
GCACTTTGGC ACGTTGTCCT CACTGCAGGA AAGTGTCATC TATTGGGCGC AGATACCCAC 
GTAAGAGATG TATCTGCTGC TTCTTGCTTG GCTTGCTTTT GGCAGTCACT GCCACTGGCC 
TTGCCTTTGG CACATGGAAG CATGCACGGC GATATGGAGG CATCTATGCA GCCTGGGCAT 
TTGTCATCCT GTTGGCTGTG CTGTGTTTGG GCCGGGCTCT TTATTGGGCC TGTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PIP4P1 ( XM_024449740.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024305508.1 Homo sapiens phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 (PIP4P1), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu103952
Clone ID Related Accession (Same CDS sequence)	XM_024449740.1
Accession Version	XM_024449740.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 696bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000014.9) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGGCAG ATGGAGAGCG TTCCCCGCTG CTGTCTGAGC CCATCGACGG TGGCGCGGGC 
GGCAACGGTT TAGTGGGGCC CGGCGGGAGT GGGGCTGGGC CCGGGGGAGG CCTGACCCCC 
TCCGCACCAC CGTACGGAGC CGCATTTCCC CCGTTTCCCG AGGGGCATCC AGCCGTGTTG 
CCTGGGGAGG ACCCACCCCC CTATTCACCC TTAACTAGCC CGGACAGTGG GAGTGCCCCT 
ATGATCACCT GCCGAGTCTG CCAATCTCTC ATCAACGTGG AAGGCAAGAT GCATCAGCAT 
GTAGTCAAAT GTGGTGTCTG CAATGAAGCC ACCCCAATCA AGAATGCACC CCCAGGGAAA 
AAATATGTTC GATGCCCCTG TAACTGTCTC CTTATCTGCA AAGTGACATC CCAACGGATT 
GCATGCCCTC GGCCCTACTG TGGACAGAGT TCACAGACCG CACTTTGGCA CGTTGTCCTC 
ACTGCAGGAA AGTGTCATCT ATTGGGCGCA GATACCCACG TAAGAGATGT ATCTGCTGCT 
TCTTGCTTGG CTTGCTTTTG GCAGTCACTG CCACTGGCCT TGCCTTTGGC ACATGGAAGC 
ATGCACGGCG ATATGGAGGC ATCTATGCAG CCTGGGCATT TGTCATCCTG TTGGCTGTGC 
TGTGTTTGGG CCGGGCTCTT TATTGGGCCT GTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024305508.1
CDS	288..983
Translation	MAADGERSPLLSEPIDGGAGGNGLVGPGGSGAGPGGGLTPSAPPYGAAFPPFPEGHPAVLPGEDPPPYSPLTSPDSGSAPMITCRVCQSLINVEGKMHQHVVKCGVCNEATPIKNAPPGKKYVRCPCNCLLICKVTSQRIACPRPYCGQSSQTALWHVVLTAGKCHLLGADTHVRDVSAASCLACFWQSLPLALPLAHGSMHGDMEASMQPGHLSSCWLCCVWAGLFIGPV

Target ORF information:

RefSeq Version	XM_024449740.1
Organism	Homo sapiens(human)
Definition	Homo sapiens phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 (PIP4P1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024449740.1

ORF Insert Sequence:

ATGGCGGCAG ATGGAGAGCG TTCCCCGCTG CTGTCTGAGC CCATCGACGG TGGCGCGGGC 
GGCAACGGTT TAGTGGGGCC CGGCGGGAGT GGGGCTGGGC CCGGGGGAGG CCTGACCCCC 
TCCGCACCAC CGTACGGAGC CGCATTTCCC CCGTTTCCCG AGGGGCATCC AGCCGTGTTG 
CCTGGGGAGG ACCCACCCCC CTATTCACCC TTAACTAGCC CGGACAGTGG GAGTGCCCCT 
ATGATCACCT GCCGAGTCTG CCAATCTCTC ATCAACGTGG AAGGCAAGAT GCATCAGCAT 
GTAGTCAAAT GTGGTGTCTG CAATGAAGCC ACCCCAATCA AGAATGCACC CCCAGGGAAA 
AAATATGTTC GATGCCCCTG TAACTGTCTC CTTATCTGCA AAGTGACATC CCAACGGATT 
GCATGCCCTC GGCCCTACTG TGGACAGAGT TCACAGACCG CACTTTGGCA CGTTGTCCTC 
ACTGCAGGAA AGTGTCATCT ATTGGGCGCA GATACCCACG TAAGAGATGT ATCTGCTGCT 
TCTTGCTTGG CTTGCTTTTG GCAGTCACTG CCACTGGCCT TGCCTTTGGC ACATGGAAGC 
ATGCACGGCG ATATGGAGGC ATCTATGCAG CCTGGGCATT TGTCATCCTG TTGGCTGTGC 
TGTGTTTGGG CCGGGCTCTT TATTGGGCCT GTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PIP4P1 ( NM_144568.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_653169.2 Homo sapiens phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 (PIP4P1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu06320
Clone ID Related Accession (Same CDS sequence)	NM_144568.3
Accession Version	NM_144568.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 834bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1556812800000
Organism	Homo sapiens(human)
Product	type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK314021.1, BX161490.1 and CA430067.1. On Jan 15, 2014 this sequence version replaced NM_144568.2. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.498426.1, BC020947.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCAG ATGGAGAGCG TTCCCCGCTG CTGTCTGAGC CCATCGACGG TGGCGCGGGC 
GGCAACGGTT TAGTGGGGCC CGGCGGGAGT GGGGCTGGGC CCGGGGGAGG CCTGACCCCC 
TCCGCACCAC CGTACGGAGC CGCATTTCCC CCGTTTCCCG AGGGGCATCC AGCCGTGTTG 
CCTGGGGAGG ACCCACCCCC CTATTCACCC TTAACTAGCC CGGACAGTGG GAGTGCCCCT 
ATGATCACCT GCCGAGTCTG CCAATCTCTC ATCAACGTGG AAGGCAAGAT GCATCAGCAT 
GTAGTCAAAT GTGGTGTCTG CAATGAAGCC ACCCCAATCA AGAATGCACC CCCAGGGAAA 
AAATATGTTC GATGCCCCTG TAACTGTCTC CTTATCTGCA AAGTGACATC CCAACGGATT 
GCATGCCCTC GGCCCTACTG CAAAAGAATC ATCAACCTGG GGCCTGTGCA TCCCGGACCT 
CTGAGTCCAG AACCCCAACC CATGGGTGTC AGGGTTATCT GTGGACATTG CAAGAATACT 
TTTCTGTGGA CAGAGTTCAC AGACCGCACT TTGGCACGTT GTCCTCACTG CAGGAAAGTG 
TCATCTATTG GGCGCAGATA CCCACGTAAG AGATGTATCT GCTGCTTCTT GCTTGGCTTG 
CTTTTGGCAG TCACTGCCAC TGGCCTTGCC TTTGGCACAT GGAAGCATGC ACGGCGATAT 
GGAGGCATCT ATGCAGCCTG GGCATTTGTC ATCCTGTTGG CTGTGCTGTG TTTGGGCCGG 
GCTCTTTATT GGGCCTGTAT GAAGGTCAGC CACCCTGTCC AGAACTTCTC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_653169.2
CDS	288..1121
Translation	MAADGERSPLLSEPIDGGAGGNGLVGPGGSGAGPGGGLTPSAPPYGAAFPPFPEGHPAVLPGEDPPPYSPLTSPDSGSAPMITCRVCQSLINVEGKMHQHVVKCGVCNEATPIKNAPPGKKYVRCPCNCLLICKVTSQRIACPRPYCKRIINLGPVHPGPLSPEPQPMGVRVICGHCKNTFLWTEFTDRTLARCPHCRKVSSIGRRYPRKRCICCFLLGLLLAVTATGLAFGTWKHARRYGGIYAAWAFVILLAVLCLGRALYWACMKVSHPVQNFS

Target ORF information:

RefSeq Version	NM_144568.3
Organism	Homo sapiens(human)
Definition	Homo sapiens phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 (PIP4P1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_144568.3

ORF Insert Sequence:

ATGGCGGCAG ATGGAGAGCG TTCCCCGCTG CTGTCTGAGC CCATCGACGG TGGCGCGGGC 
GGCAACGGTT TAGTGGGGCC CGGCGGGAGT GGGGCTGGGC CCGGGGGAGG CCTGACCCCC 
TCCGCACCAC CGTACGGAGC CGCATTTCCC CCGTTTCCCG AGGGGCATCC AGCCGTGTTG 
CCTGGGGAGG ACCCACCCCC CTATTCACCC TTAACTAGCC CGGACAGTGG GAGTGCCCCT 
ATGATCACCT GCCGAGTCTG CCAATCTCTC ATCAACGTGG AAGGCAAGAT GCATCAGCAT 
GTAGTCAAAT GTGGTGTCTG CAATGAAGCC ACCCCAATCA AGAATGCACC CCCAGGGAAA 
AAATATGTTC GATGCCCCTG TAACTGTCTC CTTATCTGCA AAGTGACATC CCAACGGATT 
GCATGCCCTC GGCCCTACTG CAAAAGAATC ATCAACCTGG GGCCTGTGCA TCCCGGACCT 
CTGAGTCCAG AACCCCAACC CATGGGTGTC AGGGTTATCT GTGGACATTG CAAGAATACT 
TTTCTGTGGA CAGAGTTCAC AGACCGCACT TTGGCACGTT GTCCTCACTG CAGGAAAGTG 
TCATCTATTG GGCGCAGATA CCCACGTAAG AGATGTATCT GCTGCTTCTT GCTTGGCTTG 
CTTTTGGCAG TCACTGCCAC TGGCCTTGCC TTTGGCACAT GGAAGCATGC ACGGCGATAT 
GGAGGCATCT ATGCAGCCTG GGCATTTGTC ATCCTGTTGG CTGTGCTGTG TTTGGGCCGG 
GCTCTTTATT GGGCCTGTAT GAAGGTCAGC CACCCTGTCC AGAACTTCTC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

TMEM55B contributes to lysosomal homeostasis and amino acid-induced mTORC1 activation.
Genes to cells : devoted to molecular & cellular mechanisms23(6)418-434(2018 Jun)
Hashimoto Y,Shirane M,Nakayama KI

TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes.
Nature communications8(1)1580(2017 11)
Willett R,Martina JA,Zewe JP,Wills R,Hammond GRV,Puertollano R

Genetic analysis of the pathogenic molecular sub-phenotype interferon-alpha identifies multiple novel loci involved in systemic lupus erythematosus.
Genes and immunity16(1)15-23(2015 Jan-Feb)
Kariuki SN,Ghodke-Puranik Y,Dorschner JM,Chrabot BS,Kelly JA,Tsao BP,Kimberly RP,Alarcón-Riquelme ME,Jacob CO,Criswell LA,Sivils KL,Langefeld CD,Harley JB,Skol AD,Niewold TB

Transmembrane protein 55B is a novel regulator of cellular cholesterol metabolism.
Arteriosclerosis, thrombosis, and vascular biology34(9)1917-23(2014 Sep)
Medina MW,Bauzon F,Naidoo D,Theusch E,Stevens K,Schilde J,Schubert C,Mangravite LM,Rudel LL,Temel RE,Runz H,Krauss RM

Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis.
Proceedings of the National Academy of Sciences of the United States of America104(43)16834-9(2007 Oct)
Zou J,Marjanovic J,Kisseleva MV,Wilson M,Majerus PW

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PIP4P1 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

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ORF Insert Sequence:

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ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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