RIPK2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RIPK2
Entrez Gene ID	8767
Full Name	receptor interacting serine/threonine kinase 2
Synonyms	CARD3,CARDIAK,CCK,GIG30,RICK,RIP2
General protein information	Preferred Names receptor interacting serine/threonine kinase 2 Names receptor-interacting serine/threonine-protein kinase 2 CARD-carrying kinase CARD-containing IL-1 beta ICE-kinase CARD-containing interleukin-1 beta-converting enzyme (ICE)-associated kinase RIP-2 growth-inhibiting gene 30 receptor-interacting protein (RIP)-like interacting caspase-like apoptosis regulatory protein (CLARP) kinase receptor-interacting protein 2 tyrosine-protein kinase RIPK2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8q21.3
Summary	This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli. [provided by RefSeq, Jul 2008].
Disorder MIM:	603455

mRNA and Protein(s)

mRNA	Protein	Name
NM_001375360.1	NP_001362289.1	receptor-interacting serine/threonine-protein kinase 2 isoform 2
XM_005251092.3	XP_005251149.1	receptor-interacting serine/threonine-protein kinase 2 isoform X1
XM_011517357.2	XP_011515659.1	receptor-interacting serine/threonine-protein kinase 2 isoform X2
NM_003821.5	NP_003812.1	receptor-interacting serine/threonine-protein kinase 2
NM_003821.6	NP_003812.1	receptor-interacting serine/threonine-protein kinase 2 isoform 1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	RIPK2	NP_001029782.1
Danio rerio (zebrafish)	ripk2	NP_919392.2
Canis lupus familiaris (dog)	RIPK2	XP_005638158.1
Mus musculus (house mouse)	Ripk2	NP_620402.1
Pan troglodytes (chimpanzee)	RIPK2	XP_519850.2
Macaca mulatta (Rhesus monkey)	RIPK2	XP_001084687.1
Rattus norvegicus (Norway rat)	Ripk2	NP_001178794.1
Xenopus tropicalis (tropical clawed frog)	ripk2	XP_002939201.2
Homo sapiens (human)	RIPK2	NP_003812.1
Gallus gallus (chicken)	RIPK2	NP_001026114.1

Gene Ontology
Bibliography

Related articles in PubMed

Association between Genetic Polymorphisms of Inflammatory Response Genes and Acute Pancreatitis.
Rodriguez-Nicolas A, Jiménez P, Carmona FD, Martín J, Matas Cobos AM, Ruiz-Cabello F, Redondo-Cerezo E
Immunological investigations48(6)585-596(2019 Aug)

Structural basis of RIP2 activation and signaling.
Gong Q, Long Z, Zhong FL, Teo DET, Jin Y, Yin Z, Boo ZZ, Zhang Y, Zhang J, Yang R, Bhushan S, Reversade B, Li Z, Wu B
Nature communications9(1)4993(2018 11)

Single-Nucleotide Polymorphisms in NOD1, RIPK2, MICB, PLCE1, TNF, and IKBKE Genes Associated with Symptomatic Dengue in Children from Colombia.
Useche YM, Ribeiro-Alves M, Restrepo BN, Salgado DM, Narváez CF, Campo O, Avendaño E, Martínez C, Chacon-Duque JC, Bedoya G
Viral immunology31(9)613-623(2018 11)

RIP2 filament formation is required for NOD2 dependent NF-κB signalling.
Pellegrini E, Desfosses A, Wallmann A, Schulze WM, Rehbein K, Mas P, Signor L, Gaudon S, Zenkeviciute G, Hons M, Malet H, Gutsche I, Sachse C, Schoehn G, Oschkinat H, Cusack S
Nature communications9(1)4043(2018 10)

Computational design of new protein kinase 2 inhibitors for the treatment of inflammatory diseases using QSAR, pharmacophore-structure-based virtual screening, and molecular dynamics.
Cruz JV, Serafim RB, da Silva GM, Giuliatti S, Rosa JMC, Araújo Neto MF, Leite FHA, Taft CA, da Silva CHTP, Santos CBR
Journal of molecular modeling24(9)225(2018 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following RIPK2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RIPK2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18621	NM_003821.6 Latest version!	Homo sapiens receptor interacting serine/threonine kinase 2 (RIPK2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu42599	NM_001375360.1 Latest version!	Homo sapiens receptor interacting serine/threonine kinase 2 (RIPK2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OHu42599	XM_005251092.3 Latest version!	Homo sapiens receptor interacting serine/threonine kinase 2 (RIPK2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OHu62165	XM_011517357.2 Latest version!	Homo sapiens receptor interacting serine/threonine kinase 2 (RIPK2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
View Old Accession Versions >>
OHu18621	NM_003821.5	Homo sapiens receptor interacting serine/threonine kinase 2 (RIPK2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RIPK2 ( NM_003821.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_003812.1 Homo sapiens receptor interacting serine/threonine kinase 2 (RIPK2), mRNA.

Price & Availability↑

CloneID	OHu18621
Clone ID Related Accession (Same CDS sequence)	NM_003821.5 , NM_003821.6
Accession Version	NM_003821.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1623bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1514217600000
Organism	Homo sapiens(human)
Product	receptor-interacting serine/threonine-protein kinase 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA040898.1, AY358814.1 and AI824070.1. This sequence is a reference standard in the RefSeqGene project. On Apr 21, 2006 this sequence version replaced NM_003821.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.95404.1, AY358814.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAACGGGG AGGCCATCTG CAGCGCCCTG CCCACCATTC CCTACCACAA ACTCGCCGAC 
CTGCGCTACC TGAGCCGCGG CGCCTCTGGC ACTGTGTCGT CCGCCCGCCA CGCAGACTGG 
CGCGTCCAGG TGGCCGTGAA GCACCTGCAC ATCCACACTC CGCTGCTCGA CAGTGAAAGA 
AAGGATGTCT TAAGAGAAGC TGAAATTTTA CACAAAGCTA GATTTAGTTA CATTCTTCCA 
ATTTTGGGAA TTTGCAATGA GCCTGAATTT TTGGGAATAG TTACTGAATA CATGCCAAAT 
GGATCATTAA ATGAACTCCT ACATAGGAAA ACTGAATATC CTGATGTTGC TTGGCCATTG 
AGATTTCGCA TCCTGCATGA AATTGCCCTT GGTGTAAATT ACCTGCACAA TATGACTCCT 
CCTTTACTTC ATCATGACTT GAAGACTCAG AATATCTTAT TGGACAATGA ATTTCATGTT 
AAGATTGCAG ATTTTGGTTT ATCAAAGTGG CGCATGATGT CCCTCTCACA GTCACGAAGT 
AGCAAATCTG CACCAGAAGG AGGGACAATT ATCTATATGC CACCTGAAAA CTATGAACCT 
GGACAAAAAT CAAGGGCCAG TATCAAGCAC GATATATATA GCTATGCAGT TATCACATGG 
GAAGTGTTAT CCAGAAAACA GCCTTTTGAA GATGTCACCA ATCCTTTGCA GATAATGTAT 
AGTGTGTCAC AAGGACATCG ACCTGTTATT AATGAAGAAA GTTTGCCATA TGATATACCT 
CACCGAGCAC GTATGATCTC TCTAATAGAA AGTGGATGGG CACAAAATCC AGATGAAAGA 
CCATCTTTCT TAAAATGTTT AATAGAACTT GAACCAGTTT TGAGAACATT TGAAGAGATA 
ACTTTTCTTG AAGCTGTTAT TCAGCTAAAG AAAACAAAGT TACAGAGTGT TTCAAGTGCC 
ATTCACCTAT GTGACAAGAA GAAAATGGAA TTATCTCTGA ACATACCTGT AAATCATGGT 
CCACAAGAGG AATCATGTGG ATCCTCTCAG CTCCATGAAA ATAGTGGTTC TCCTGAAACT 
TCAAGGTCCC TGCCAGCTCC TCAAGACAAT GATTTTTTAT CTAGAAAAGC TCAAGACTGT 
TATTTTATGA AGCTGCATCA CTGTCCTGGA AATCACAGTT GGGATAGCAC CATTTCTGGA 
TCTCAAAGGG CTGCATTCTG TGATCACAAG ACCACTCCAT GCTCTTCAGC AATAATAAAT 
CCACTCTCAA CTGCAGGAAA CTCAGAACGT CTGCAGCCTG GTATAGCCCA GCAGTGGATC 
CAGAGCAAAA GGGAAGACAT TGTGAACCAA ATGACAGAAG CCTGCCTTAA CCAGTCGCTA 
GATGCCCTTC TGTCCAGGGA CTTGATCATG AAAGAGGACT ATGAACTTGT TAGTACCAAG 
CCTACAAGGA CCTCAAAAGT CAGACAATTA CTAGACACTA CTGACATCCA AGGAGAAGAA 
TTTGCCAAAG TTATAGTACA AAAATTGAAA GATAACAAAC AAATGGGTCT TCAGCCTTAC 
CCGGAAATAC TTGTGGTTTC TAGATCACCA TCTTTAAATT TACTTCAAAA TAAAAGCATG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003812.1
CDS	315..1937
Translation	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM

Target ORF information:

RefSeq Version	NM_003821.5
Organism	Homo sapiens(human)
Definition	Homo sapiens receptor interacting serine/threonine kinase 2 (RIPK2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003821.5

ORF Insert Sequence:

ATGAACGGGG AGGCCATCTG CAGCGCCCTG CCCACCATTC CCTACCACAA ACTCGCCGAC 
CTGCGCTACC TGAGCCGCGG CGCCTCTGGC ACTGTGTCGT CCGCCCGCCA CGCAGACTGG 
CGCGTCCAGG TGGCCGTGAA GCACCTGCAC ATCCACACTC CGCTGCTCGA CAGTGAAAGA 
AAGGATGTCT TAAGAGAAGC TGAAATTTTA CACAAAGCTA GATTTAGTTA CATTCTTCCA 
ATTTTGGGAA TTTGCAATGA GCCTGAATTT TTGGGAATAG TTACTGAATA CATGCCAAAT 
GGATCATTAA ATGAACTCCT ACATAGGAAA ACTGAATATC CTGATGTTGC TTGGCCATTG 
AGATTTCGCA TCCTGCATGA AATTGCCCTT GGTGTAAATT ACCTGCACAA TATGACTCCT 
CCTTTACTTC ATCATGACTT GAAGACTCAG AATATCTTAT TGGACAATGA ATTTCATGTT 
AAGATTGCAG ATTTTGGTTT ATCAAAGTGG CGCATGATGT CCCTCTCACA GTCACGAAGT 
AGCAAATCTG CACCAGAAGG AGGGACAATT ATCTATATGC CACCTGAAAA CTATGAACCT 
GGACAAAAAT CAAGGGCCAG TATCAAGCAC GATATATATA GCTATGCAGT TATCACATGG 
GAAGTGTTAT CCAGAAAACA GCCTTTTGAA GATGTCACCA ATCCTTTGCA GATAATGTAT 
AGTGTGTCAC AAGGACATCG ACCTGTTATT AATGAAGAAA GTTTGCCATA TGATATACCT 
CACCGAGCAC GTATGATCTC TCTAATAGAA AGTGGATGGG CACAAAATCC AGATGAAAGA 
CCATCTTTCT TAAAATGTTT AATAGAACTT GAACCAGTTT TGAGAACATT TGAAGAGATA 
ACTTTTCTTG AAGCTGTTAT TCAGCTAAAG AAAACAAAGT TACAGAGTGT TTCAAGTGCC 
ATTCACCTAT GTGACAAGAA GAAAATGGAA TTATCTCTGA ACATACCTGT AAATCATGGT 
CCACAAGAGG AATCATGTGG ATCCTCTCAG CTCCATGAAA ATAGTGGTTC TCCTGAAACT 
TCAAGGTCCC TGCCAGCTCC TCAAGACAAT GATTTTTTAT CTAGAAAAGC TCAAGACTGT 
TATTTTATGA AGCTGCATCA CTGTCCTGGA AATCACAGTT GGGATAGCAC CATTTCTGGA 
TCTCAAAGGG CTGCATTCTG TGATCACAAG ACCACTCCAT GCTCTTCAGC AATAATAAAT 
CCACTCTCAA CTGCAGGAAA CTCAGAACGT CTGCAGCCTG GTATAGCCCA GCAGTGGATC 
CAGAGCAAAA GGGAAGACAT TGTGAACCAA ATGACAGAAG CCTGCCTTAA CCAGTCGCTA 
GATGCCCTTC TGTCCAGGGA CTTGATCATG AAAGAGGACT ATGAACTTGT TAGTACCAAG 
CCTACAAGGA CCTCAAAAGT CAGACAATTA CTAGACACTA CTGACATCCA AGGAGAAGAA 
TTTGCCAAAG TTATAGTACA AAAATTGAAA GATAACAAAC AAATGGGTCT TCAGCCTTAC 
CCGGAAATAC TTGTGGTTTC TAGATCACCA TCTTTAAATT TACTTCAAAA TAAAAGCATG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RIPK2 ( NM_003821.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_003812.1 Homo sapiens receptor interacting serine/threonine kinase 2 (RIPK2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu18621
Clone ID Related Accession (Same CDS sequence)	NM_003821.5 , NM_003821.6
Accession Version	NM_003821.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1623bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577548800000
Organism	Homo sapiens(human)
Product	receptor-interacting serine/threonine-protein kinase 2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY358814.1 and AI824070.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_003821.5. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY358814.1, SRR1660807.150538.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000220751.5/ ENSP00000220751.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAACGGGG AGGCCATCTG CAGCGCCCTG CCCACCATTC CCTACCACAA ACTCGCCGAC 
CTGCGCTACC TGAGCCGCGG CGCCTCTGGC ACTGTGTCGT CCGCCCGCCA CGCAGACTGG 
CGCGTCCAGG TGGCCGTGAA GCACCTGCAC ATCCACACTC CGCTGCTCGA CAGTGAAAGA 
AAGGATGTCT TAAGAGAAGC TGAAATTTTA CACAAAGCTA GATTTAGTTA CATTCTTCCA 
ATTTTGGGAA TTTGCAATGA GCCTGAATTT TTGGGAATAG TTACTGAATA CATGCCAAAT 
GGATCATTAA ATGAACTCCT ACATAGGAAA ACTGAATATC CTGATGTTGC TTGGCCATTG 
AGATTTCGCA TCCTGCATGA AATTGCCCTT GGTGTAAATT ACCTGCACAA TATGACTCCT 
CCTTTACTTC ATCATGACTT GAAGACTCAG AATATCTTAT TGGACAATGA ATTTCATGTT 
AAGATTGCAG ATTTTGGTTT ATCAAAGTGG CGCATGATGT CCCTCTCACA GTCACGAAGT 
AGCAAATCTG CACCAGAAGG AGGGACAATT ATCTATATGC CACCTGAAAA CTATGAACCT 
GGACAAAAAT CAAGGGCCAG TATCAAGCAC GATATATATA GCTATGCAGT TATCACATGG 
GAAGTGTTAT CCAGAAAACA GCCTTTTGAA GATGTCACCA ATCCTTTGCA GATAATGTAT 
AGTGTGTCAC AAGGACATCG ACCTGTTATT AATGAAGAAA GTTTGCCATA TGATATACCT 
CACCGAGCAC GTATGATCTC TCTAATAGAA AGTGGATGGG CACAAAATCC AGATGAAAGA 
CCATCTTTCT TAAAATGTTT AATAGAACTT GAACCAGTTT TGAGAACATT TGAAGAGATA 
ACTTTTCTTG AAGCTGTTAT TCAGCTAAAG AAAACAAAGT TACAGAGTGT TTCAAGTGCC 
ATTCACCTAT GTGACAAGAA GAAAATGGAA TTATCTCTGA ACATACCTGT AAATCATGGT 
CCACAAGAGG AATCATGTGG ATCCTCTCAG CTCCATGAAA ATAGTGGTTC TCCTGAAACT 
TCAAGGTCCC TGCCAGCTCC TCAAGACAAT GATTTTTTAT CTAGAAAAGC TCAAGACTGT 
TATTTTATGA AGCTGCATCA CTGTCCTGGA AATCACAGTT GGGATAGCAC CATTTCTGGA 
TCTCAAAGGG CTGCATTCTG TGATCACAAG ACCACTCCAT GCTCTTCAGC AATAATAAAT 
CCACTCTCAA CTGCAGGAAA CTCAGAACGT CTGCAGCCTG GTATAGCCCA GCAGTGGATC 
CAGAGCAAAA GGGAAGACAT TGTGAACCAA ATGACAGAAG CCTGCCTTAA CCAGTCGCTA 
GATGCCCTTC TGTCCAGGGA CTTGATCATG AAAGAGGACT ATGAACTTGT TAGTACCAAG 
CCTACAAGGA CCTCAAAAGT CAGACAATTA CTAGACACTA CTGACATCCA AGGAGAAGAA 
TTTGCCAAAG TTATAGTACA AAAATTGAAA GATAACAAAC AAATGGGTCT TCAGCCTTAC 
CCGGAAATAC TTGTGGTTTC TAGATCACCA TCTTTAAATT TACTTCAAAA TAAAAGCATG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003812.1
CDS	246..1868
Translation	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM

Target ORF information:

RefSeq Version	NM_003821.6
Organism	Homo sapiens(human)
Definition	Homo sapiens receptor interacting serine/threonine kinase 2 (RIPK2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003821.6

ORF Insert Sequence:

ATGAACGGGG AGGCCATCTG CAGCGCCCTG CCCACCATTC CCTACCACAA ACTCGCCGAC 
CTGCGCTACC TGAGCCGCGG CGCCTCTGGC ACTGTGTCGT CCGCCCGCCA CGCAGACTGG 
CGCGTCCAGG TGGCCGTGAA GCACCTGCAC ATCCACACTC CGCTGCTCGA CAGTGAAAGA 
AAGGATGTCT TAAGAGAAGC TGAAATTTTA CACAAAGCTA GATTTAGTTA CATTCTTCCA 
ATTTTGGGAA TTTGCAATGA GCCTGAATTT TTGGGAATAG TTACTGAATA CATGCCAAAT 
GGATCATTAA ATGAACTCCT ACATAGGAAA ACTGAATATC CTGATGTTGC TTGGCCATTG 
AGATTTCGCA TCCTGCATGA AATTGCCCTT GGTGTAAATT ACCTGCACAA TATGACTCCT 
CCTTTACTTC ATCATGACTT GAAGACTCAG AATATCTTAT TGGACAATGA ATTTCATGTT 
AAGATTGCAG ATTTTGGTTT ATCAAAGTGG CGCATGATGT CCCTCTCACA GTCACGAAGT 
AGCAAATCTG CACCAGAAGG AGGGACAATT ATCTATATGC CACCTGAAAA CTATGAACCT 
GGACAAAAAT CAAGGGCCAG TATCAAGCAC GATATATATA GCTATGCAGT TATCACATGG 
GAAGTGTTAT CCAGAAAACA GCCTTTTGAA GATGTCACCA ATCCTTTGCA GATAATGTAT 
AGTGTGTCAC AAGGACATCG ACCTGTTATT AATGAAGAAA GTTTGCCATA TGATATACCT 
CACCGAGCAC GTATGATCTC TCTAATAGAA AGTGGATGGG CACAAAATCC AGATGAAAGA 
CCATCTTTCT TAAAATGTTT AATAGAACTT GAACCAGTTT TGAGAACATT TGAAGAGATA 
ACTTTTCTTG AAGCTGTTAT TCAGCTAAAG AAAACAAAGT TACAGAGTGT TTCAAGTGCC 
ATTCACCTAT GTGACAAGAA GAAAATGGAA TTATCTCTGA ACATACCTGT AAATCATGGT 
CCACAAGAGG AATCATGTGG ATCCTCTCAG CTCCATGAAA ATAGTGGTTC TCCTGAAACT 
TCAAGGTCCC TGCCAGCTCC TCAAGACAAT GATTTTTTAT CTAGAAAAGC TCAAGACTGT 
TATTTTATGA AGCTGCATCA CTGTCCTGGA AATCACAGTT GGGATAGCAC CATTTCTGGA 
TCTCAAAGGG CTGCATTCTG TGATCACAAG ACCACTCCAT GCTCTTCAGC AATAATAAAT 
CCACTCTCAA CTGCAGGAAA CTCAGAACGT CTGCAGCCTG GTATAGCCCA GCAGTGGATC 
CAGAGCAAAA GGGAAGACAT TGTGAACCAA ATGACAGAAG CCTGCCTTAA CCAGTCGCTA 
GATGCCCTTC TGTCCAGGGA CTTGATCATG AAAGAGGACT ATGAACTTGT TAGTACCAAG 
CCTACAAGGA CCTCAAAAGT CAGACAATTA CTAGACACTA CTGACATCCA AGGAGAAGAA 
TTTGCCAAAG TTATAGTACA AAAATTGAAA GATAACAAAC AAATGGGTCT TCAGCCTTAC 
CCGGAAATAC TTGTGGTTTC TAGATCACCA TCTTTAAATT TACTTCAAAA TAAAAGCATG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RIPK2 ( NM_001375360.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001362289.1 Homo sapiens receptor interacting serine/threonine kinase 2 (RIPK2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu42599
Clone ID Related Accession (Same CDS sequence)	NM_001375360.1 , XM_005251092.3
Accession Version	NM_001375360.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1212bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1578067200000
Organism	Homo sapiens(human)
Product	receptor-interacting serine/threonine-protein kinase 2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF117829.3. On Oct 25, 2019 this sequence version replaced XM_005251092.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY358813.1, AK301448.1 [ECO:0000332] ##Evidence-Data-END##

ATGACTCCTC CTTTACTTCA TCATGACTTG AAGACTCAGA ATATCTTATT GGACAATGAA 
TTTCATGTTA AGATTGCAGA TTTTGGTTTA TCAAAGTGGC GCATGATGTC CCTCTCACAG 
TCACGAAGTA GCAAATCTGC ACCAGAAGGA GGGACAATTA TCTATATGCC ACCTGAAAAC 
TATGAACCTG GACAAAAATC AAGGGCCAGT ATCAAGCACG ATATATATAG CTATGCAGTT 
ATCACATGGG AAGTGTTATC CAGAAAACAG CCTTTTGAAG ATGTCACCAA TCCTTTGCAG 
ATAATGTATA GTGTGTCACA AGGACATCGA CCTGTTATTA ATGAAGAAAG TTTGCCATAT 
GATATACCTC ACCGAGCACG TATGATCTCT CTAATAGAAA GTGGATGGGC ACAAAATCCA 
GATGAAAGAC CATCTTTCTT AAAATGTTTA ATAGAACTTG AACCAGTTTT GAGAACATTT 
GAAGAGATAA CTTTTCTTGA AGCTGTTATT CAGCTAAAGA AAACAAAGTT ACAGAGTGTT 
TCAAGTGCCA TTCACCTATG TGACAAGAAG AAAATGGAAT TATCTCTGAA CATACCTGTA 
AATCATGGTC CACAAGAGGA ATCATGTGGA TCCTCTCAGC TCCATGAAAA TAGTGGTTCT 
CCTGAAACTT CAAGGTCCCT GCCAGCTCCT CAAGACAATG ATTTTTTATC TAGAAAAGCT 
CAAGACTGTT ATTTTATGAA GCTGCATCAC TGTCCTGGAA ATCACAGTTG GGATAGCACC 
ATTTCTGGAT CTCAAAGGGC TGCATTCTGT GATCACAAGA CCACTCCATG CTCTTCAGCA 
ATAATAAATC CACTCTCAAC TGCAGGAAAC TCAGAACGTC TGCAGCCTGG TATAGCCCAG 
CAGTGGATCC AGAGCAAAAG GGAAGACATT GTGAACCAAA TGACAGAAGC CTGCCTTAAC 
CAGTCGCTAG ATGCCCTTCT GTCCAGGGAC TTGATCATGA AAGAGGACTA TGAACTTGTT 
AGTACCAAGC CTACAAGGAC CTCAAAAGTC AGACAATTAC TAGACACTAC TGACATCCAA 
GGAGAAGAAT TTGCCAAAGT TATAGTACAA AAATTGAAAG ATAACAAACA AATGGGTCTT 
CAGCCTTACC CGGAAATACT TGTGGTTTCT AGATCACCAT CTTTAAATTT ACTTCAAAAT 
AAAAGCATGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001362289.1
CDS	503..1714
Translation	MTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM

Target ORF information:

RefSeq Version	NM_001375360.1
Organism	Homo sapiens(human)
Definition	Homo sapiens receptor interacting serine/threonine kinase 2 (RIPK2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001375360.1

ORF Insert Sequence:

ATGACTCCTC CTTTACTTCA TCATGACTTG AAGACTCAGA ATATCTTATT GGACAATGAA 
TTTCATGTTA AGATTGCAGA TTTTGGTTTA TCAAAGTGGC GCATGATGTC CCTCTCACAG 
TCACGAAGTA GCAAATCTGC ACCAGAAGGA GGGACAATTA TCTATATGCC ACCTGAAAAC 
TATGAACCTG GACAAAAATC AAGGGCCAGT ATCAAGCACG ATATATATAG CTATGCAGTT 
ATCACATGGG AAGTGTTATC CAGAAAACAG CCTTTTGAAG ATGTCACCAA TCCTTTGCAG 
ATAATGTATA GTGTGTCACA AGGACATCGA CCTGTTATTA ATGAAGAAAG TTTGCCATAT 
GATATACCTC ACCGAGCACG TATGATCTCT CTAATAGAAA GTGGATGGGC ACAAAATCCA 
GATGAAAGAC CATCTTTCTT AAAATGTTTA ATAGAACTTG AACCAGTTTT GAGAACATTT 
GAAGAGATAA CTTTTCTTGA AGCTGTTATT CAGCTAAAGA AAACAAAGTT ACAGAGTGTT 
TCAAGTGCCA TTCACCTATG TGACAAGAAG AAAATGGAAT TATCTCTGAA CATACCTGTA 
AATCATGGTC CACAAGAGGA ATCATGTGGA TCCTCTCAGC TCCATGAAAA TAGTGGTTCT 
CCTGAAACTT CAAGGTCCCT GCCAGCTCCT CAAGACAATG ATTTTTTATC TAGAAAAGCT 
CAAGACTGTT ATTTTATGAA GCTGCATCAC TGTCCTGGAA ATCACAGTTG GGATAGCACC 
ATTTCTGGAT CTCAAAGGGC TGCATTCTGT GATCACAAGA CCACTCCATG CTCTTCAGCA 
ATAATAAATC CACTCTCAAC TGCAGGAAAC TCAGAACGTC TGCAGCCTGG TATAGCCCAG 
CAGTGGATCC AGAGCAAAAG GGAAGACATT GTGAACCAAA TGACAGAAGC CTGCCTTAAC 
CAGTCGCTAG ATGCCCTTCT GTCCAGGGAC TTGATCATGA AAGAGGACTA TGAACTTGTT 
AGTACCAAGC CTACAAGGAC CTCAAAAGTC AGACAATTAC TAGACACTAC TGACATCCAA 
GGAGAAGAAT TTGCCAAAGT TATAGTACAA AAATTGAAAG ATAACAAACA AATGGGTCTT 
CAGCCTTACC CGGAAATACT TGTGGTTTCT AGATCACCAT CTTTAAATTT ACTTCAAAAT 
AAAAGCATGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RIPK2 ( XM_005251092.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_005251149.1 Homo sapiens receptor interacting serine/threonine kinase 2 (RIPK2), transcript variant X1, mRNA.

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CloneID	OHu42599
Clone ID Related Accession (Same CDS sequence)	NM_001375360.1 , XM_005251092.3
Accession Version	XM_005251092.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1212bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1560268800000
Organism	Homo sapiens(human)
Product	receptor-interacting serine/threonine-protein kinase 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000008.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005251092.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20190607 Annotation Version :: 109.20190607 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Freeze :: 20190607 ##Genome-Annotation-Data-END##

ATGACTCCTC CTTTACTTCA TCATGACTTG AAGACTCAGA ATATCTTATT GGACAATGAA 
TTTCATGTTA AGATTGCAGA TTTTGGTTTA TCAAAGTGGC GCATGATGTC CCTCTCACAG 
TCACGAAGTA GCAAATCTGC ACCAGAAGGA GGGACAATTA TCTATATGCC ACCTGAAAAC 
TATGAACCTG GACAAAAATC AAGGGCCAGT ATCAAGCACG ATATATATAG CTATGCAGTT 
ATCACATGGG AAGTGTTATC CAGAAAACAG CCTTTTGAAG ATGTCACCAA TCCTTTGCAG 
ATAATGTATA GTGTGTCACA AGGACATCGA CCTGTTATTA ATGAAGAAAG TTTGCCATAT 
GATATACCTC ACCGAGCACG TATGATCTCT CTAATAGAAA GTGGATGGGC ACAAAATCCA 
GATGAAAGAC CATCTTTCTT AAAATGTTTA ATAGAACTTG AACCAGTTTT GAGAACATTT 
GAAGAGATAA CTTTTCTTGA AGCTGTTATT CAGCTAAAGA AAACAAAGTT ACAGAGTGTT 
TCAAGTGCCA TTCACCTATG TGACAAGAAG AAAATGGAAT TATCTCTGAA CATACCTGTA 
AATCATGGTC CACAAGAGGA ATCATGTGGA TCCTCTCAGC TCCATGAAAA TAGTGGTTCT 
CCTGAAACTT CAAGGTCCCT GCCAGCTCCT CAAGACAATG ATTTTTTATC TAGAAAAGCT 
CAAGACTGTT ATTTTATGAA GCTGCATCAC TGTCCTGGAA ATCACAGTTG GGATAGCACC 
ATTTCTGGAT CTCAAAGGGC TGCATTCTGT GATCACAAGA CCACTCCATG CTCTTCAGCA 
ATAATAAATC CACTCTCAAC TGCAGGAAAC TCAGAACGTC TGCAGCCTGG TATAGCCCAG 
CAGTGGATCC AGAGCAAAAG GGAAGACATT GTGAACCAAA TGACAGAAGC CTGCCTTAAC 
CAGTCGCTAG ATGCCCTTCT GTCCAGGGAC TTGATCATGA AAGAGGACTA TGAACTTGTT 
AGTACCAAGC CTACAAGGAC CTCAAAAGTC AGACAATTAC TAGACACTAC TGACATCCAA 
GGAGAAGAAT TTGCCAAAGT TATAGTACAA AAATTGAAAG ATAACAAACA AATGGGTCTT 
CAGCCTTACC CGGAAATACT TGTGGTTTCT AGATCACCAT CTTTAAATTT ACTTCAAAAT 
AAAAGCATGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005251149.1
CDS	536..1747
Translation	MTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM

Target ORF information:

RefSeq Version	XM_005251092.3
Organism	Homo sapiens(human)
Definition	Homo sapiens receptor interacting serine/threonine kinase 2 (RIPK2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005251092.3

ORF Insert Sequence:

ATGACTCCTC CTTTACTTCA TCATGACTTG AAGACTCAGA ATATCTTATT GGACAATGAA 
TTTCATGTTA AGATTGCAGA TTTTGGTTTA TCAAAGTGGC GCATGATGTC CCTCTCACAG 
TCACGAAGTA GCAAATCTGC ACCAGAAGGA GGGACAATTA TCTATATGCC ACCTGAAAAC 
TATGAACCTG GACAAAAATC AAGGGCCAGT ATCAAGCACG ATATATATAG CTATGCAGTT 
ATCACATGGG AAGTGTTATC CAGAAAACAG CCTTTTGAAG ATGTCACCAA TCCTTTGCAG 
ATAATGTATA GTGTGTCACA AGGACATCGA CCTGTTATTA ATGAAGAAAG TTTGCCATAT 
GATATACCTC ACCGAGCACG TATGATCTCT CTAATAGAAA GTGGATGGGC ACAAAATCCA 
GATGAAAGAC CATCTTTCTT AAAATGTTTA ATAGAACTTG AACCAGTTTT GAGAACATTT 
GAAGAGATAA CTTTTCTTGA AGCTGTTATT CAGCTAAAGA AAACAAAGTT ACAGAGTGTT 
TCAAGTGCCA TTCACCTATG TGACAAGAAG AAAATGGAAT TATCTCTGAA CATACCTGTA 
AATCATGGTC CACAAGAGGA ATCATGTGGA TCCTCTCAGC TCCATGAAAA TAGTGGTTCT 
CCTGAAACTT CAAGGTCCCT GCCAGCTCCT CAAGACAATG ATTTTTTATC TAGAAAAGCT 
CAAGACTGTT ATTTTATGAA GCTGCATCAC TGTCCTGGAA ATCACAGTTG GGATAGCACC 
ATTTCTGGAT CTCAAAGGGC TGCATTCTGT GATCACAAGA CCACTCCATG CTCTTCAGCA 
ATAATAAATC CACTCTCAAC TGCAGGAAAC TCAGAACGTC TGCAGCCTGG TATAGCCCAG 
CAGTGGATCC AGAGCAAAAG GGAAGACATT GTGAACCAAA TGACAGAAGC CTGCCTTAAC 
CAGTCGCTAG ATGCCCTTCT GTCCAGGGAC TTGATCATGA AAGAGGACTA TGAACTTGTT 
AGTACCAAGC CTACAAGGAC CTCAAAAGTC AGACAATTAC TAGACACTAC TGACATCCAA 
GGAGAAGAAT TTGCCAAAGT TATAGTACAA AAATTGAAAG ATAACAAACA AATGGGTCTT 
CAGCCTTACC CGGAAATACT TGTGGTTTCT AGATCACCAT CTTTAAATTT ACTTCAAAAT 
AAAAGCATGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RIPK2 ( XM_011517357.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011515659.1 Homo sapiens receptor interacting serine/threonine kinase 2 (RIPK2), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu62165
Clone ID Related Accession (Same CDS sequence)	XM_011517357.2
Accession Version	XM_011517357.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1110bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	receptor-interacting serine/threonine-protein kinase 2 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000008.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011517357.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATGTCCC TCTCACAGTC ACGAAGTAGC AAATCTGCAC CAGAAGGAGG GACAATTATC 
TATATGCCAC CTGAAAACTA TGAACCTGGA CAAAAATCAA GGGCCAGTAT CAAGCACGAT 
ATATATAGCT ATGCAGTTAT CACATGGGAA GTGTTATCCA GAAAACAGCC TTTTGAAGAT 
GTCACCAATC CTTTGCAGAT AATGTATAGT GTGTCACAAG GACATCGACC TGTTATTAAT 
GAAGAAAGTT TGCCATATGA TATACCTCAC CGAGCACGTA TGATCTCTCT AATAGAAAGT 
GGATGGGCAC AAAATCCAGA TGAAAGACCA TCTTTCTTAA AATGTTTAAT AGAACTTGAA 
CCAGTTTTGA GAACATTTGA AGAGATAACT TTTCTTGAAG CTGTTATTCA GCTAAAGAAA 
ACAAAGTTAC AGAGTGTTTC AAGTGCCATT CACCTATGTG ACAAGAAGAA AATGGAATTA 
TCTCTGAACA TACCTGTAAA TCATGGTCCA CAAGAGGAAT CATGTGGATC CTCTCAGCTC 
CATGAAAATA GTGGTTCTCC TGAAACTTCA AGGTCCCTGC CAGCTCCTCA AGACAATGAT 
TTTTTATCTA GAAAAGCTCA AGACTGTTAT TTTATGAAGC TGCATCACTG TCCTGGAAAT 
CACAGTTGGG ATAGCACCAT TTCTGGATCT CAAAGGGCTG CATTCTGTGA TCACAAGACC 
ACTCCATGCT CTTCAGCAAT AATAAATCCA CTCTCAACTG CAGGAAACTC AGAACGTCTG 
CAGCCTGGTA TAGCCCAGCA GTGGATCCAG AGCAAAAGGG AAGACATTGT GAACCAAATG 
ACAGAAGCCT GCCTTAACCA GTCGCTAGAT GCCCTTCTGT CCAGGGACTT GATCATGAAA 
GAGGACTATG AACTTGTTAG TACCAAGCCT ACAAGGACCT CAAAAGTCAG ACAATTACTA 
GACACTACTG ACATCCAAGG AGAAGAATTT GCCAAAGTTA TAGTACAAAA ATTGAAAGAT 
AACAAACAAA TGGGTCTTCA GCCTTACCCG GAAATACTTG TGGTTTCTAG ATCACCATCT 
TTAAATTTAC TTCAAAATAA AAGCATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011515659.1
CDS	161..1270
Translation	MMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM

Target ORF information:

RefSeq Version	XM_011517357.2
Organism	Homo sapiens(human)
Definition	Homo sapiens receptor interacting serine/threonine kinase 2 (RIPK2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011517357.2

ORF Insert Sequence:

ATGATGTCCC TCTCACAGTC ACGAAGTAGC AAATCTGCAC CAGAAGGAGG GACAATTATC 
TATATGCCAC CTGAAAACTA TGAACCTGGA CAAAAATCAA GGGCCAGTAT CAAGCACGAT 
ATATATAGCT ATGCAGTTAT CACATGGGAA GTGTTATCCA GAAAACAGCC TTTTGAAGAT 
GTCACCAATC CTTTGCAGAT AATGTATAGT GTGTCACAAG GACATCGACC TGTTATTAAT 
GAAGAAAGTT TGCCATATGA TATACCTCAC CGAGCACGTA TGATCTCTCT AATAGAAAGT 
GGATGGGCAC AAAATCCAGA TGAAAGACCA TCTTTCTTAA AATGTTTAAT AGAACTTGAA 
CCAGTTTTGA GAACATTTGA AGAGATAACT TTTCTTGAAG CTGTTATTCA GCTAAAGAAA 
ACAAAGTTAC AGAGTGTTTC AAGTGCCATT CACCTATGTG ACAAGAAGAA AATGGAATTA 
TCTCTGAACA TACCTGTAAA TCATGGTCCA CAAGAGGAAT CATGTGGATC CTCTCAGCTC 
CATGAAAATA GTGGTTCTCC TGAAACTTCA AGGTCCCTGC CAGCTCCTCA AGACAATGAT 
TTTTTATCTA GAAAAGCTCA AGACTGTTAT TTTATGAAGC TGCATCACTG TCCTGGAAAT 
CACAGTTGGG ATAGCACCAT TTCTGGATCT CAAAGGGCTG CATTCTGTGA TCACAAGACC 
ACTCCATGCT CTTCAGCAAT AATAAATCCA CTCTCAACTG CAGGAAACTC AGAACGTCTG 
CAGCCTGGTA TAGCCCAGCA GTGGATCCAG AGCAAAAGGG AAGACATTGT GAACCAAATG 
ACAGAAGCCT GCCTTAACCA GTCGCTAGAT GCCCTTCTGT CCAGGGACTT GATCATGAAA 
GAGGACTATG AACTTGTTAG TACCAAGCCT ACAAGGACCT CAAAAGTCAG ACAATTACTA 
GACACTACTG ACATCCAAGG AGAAGAATTT GCCAAAGTTA TAGTACAAAA ATTGAAAGAT 
AACAAACAAA TGGGTCTTCA GCCTTACCCG GAAATACTTG TGGTTTCTAG ATCACCATCT 
TTAAATTTAC TTCAAAATAA AAGCATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Association between Genetic Polymorphisms of Inflammatory Response Genes and Acute Pancreatitis.
Immunological investigations48(6)585-596(2019 Aug)
Rodriguez-Nicolas A,Jiménez P,Carmona FD,Martín J,Matas Cobos AM,Ruiz-Cabello F,Redondo-Cerezo E

Structural basis of RIP2 activation and signaling.
Nature communications9(1)4993(2018 11)
Gong Q,Long Z,Zhong FL,Teo DET,Jin Y,Yin Z,Boo ZZ,Zhang Y,Zhang J,Yang R,Bhushan S,Reversade B,Li Z,Wu B

Single-Nucleotide Polymorphisms in NOD1, RIPK2, MICB, PLCE1, TNF, and IKBKE Genes Associated with Symptomatic Dengue in Children from Colombia.
Viral immunology31(9)613-623(2018 11)
Useche YM,Ribeiro-Alves M,Restrepo BN,Salgado DM,Narváez CF,Campo O,Avendaño E,Martínez C,Chacon-Duque JC,Bedoya G

RIP2 filament formation is required for NOD2 dependent NF-κB signalling.
Nature communications9(1)4043(2018 10)
Pellegrini E,Desfosses A,Wallmann A,Schulze WM,Rehbein K,Mas P,Signor L,Gaudon S,Zenkeviciute G,Hons M,Malet H,Gutsche I,Sachse C,Schoehn G,Oschkinat H,Cusack S

Computational design of new protein kinase 2 inhibitors for the treatment of inflammatory diseases using QSAR, pharmacophore-structure-based virtual screening, and molecular dynamics.
Journal of molecular modeling24(9)225(2018 Aug)
Cruz JV,Serafim RB,da Silva GM,Giuliatti S,Rosa JMC,Araújo Neto MF,Leite FHA,Taft CA,da Silva CHTP,Santos CBR

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RIPK2 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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