| Gene Symbol | CRADD |
| Entrez Gene ID | 8738 |
| Full Name | CASP2 and RIPK1 domain containing adaptor with death domain |
| Synonyms | MRT34,RAIDD |
| General protein information |
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| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | This gene encodes a protein containing a death domain (DD) motif. This protein recruits caspase 2/ICH1 to the cell death signal transduction complex, which includes tumor necrosis factor receptor 1 (TNFR1A) and RIPK1/RIP kinase, and acts in promoting apoptosis. A mutation in this gene was associated with cognitive disability. A related pseudogene is found on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]. |
| Disorder MIM: | |
| Disorder Html: | Mental retardation, autosomal recessive 34, with variant lissencephaly, 614499 (3) |
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