GPR65 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GPR65
Entrez Gene ID	8477
Full Name	G protein-coupled receptor 65
Synonyms	TDAG8,hTDAG8
General protein information	Preferred Names G protein-coupled receptor 65 Names psychosine receptor T-cell death-associated gene 8 protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 14 Map Location: 14q31.3
Disorder MIM:	604620

mRNA and Protein(s)

mRNA	Protein	Name
NM_003608.4	NP_003599.2	psychosine receptor
NM_003608.3	NP_003599.2	psychosine receptor

Pathways from BioSystems

Homologies

Homo sapiens (human)	GPR65	NP_003599.2
Canis lupus familiaris (dog)	GPR65	XP_005623778.1
Rattus norvegicus (Norway rat)	Gpr65	NP_001100221.1
Gallus gallus (chicken)	GPR65	XP_004941908.1
Macaca mulatta (Rhesus monkey)	GPR65	XP_001082670.1
Xenopus tropicalis (tropical clawed frog)	gpr65	XP_002933239.1
Bos taurus (cattle)	GPR65	NP_001094773.1
Pan troglodytes (chimpanzee)	GPR65	XP_523005.1
Mus musculus (house mouse)	Gpr65	NP_032178.1

Gene Ontology
Bibliography

Related articles in PubMed

Genetic polymorphisms of G protein-coupled receptor 65 gene are associated with ankylosing spondylitis in a Chinese Han population: A case-control study.
Yuan Y, Ma Y, Zhang X, Han R, Hu X, Yang J, Wang M, Guan SY, Pan G, Xu SQ, Jiang S, Pan F
Human immunology80(2)146-150(2019 Feb)

The impact of the rs8005161 polymorphism on G protein-coupled receptor GPR65 (TDAG8) pH-associated activation in intestinal inflammation.
Tcymbarevich IV, Eloranta JJ, Rossel JB, Obialo N, Spalinger M, Cosin-Roger J, Lang S, Kullak-Ublick GA, Wagner CA, Scharl M, Seuwen K, Ruiz PA, Rogler G, de Vallière C, Misselwitz B,
BMC gastroenterology19(1)2(2019 Jan)

The role of acid-sensitive ion channels in panic disorder: a systematic review of animal studies and meta-analysis of human studies.
Quagliato LA, Freire RC, Nardi AE
Translational psychiatry8(1)185(2018 09)

Overexpression of G-protein-coupled receptors 65 in glioblastoma predicts poor patient prognosis.
Wang HX, Chen YH, Zhou JX, Hu XY, Tan C, Yan Y, Huang QL, Shen JY, Xu HC, Li F, Gong ZY, Xu T, Chen JX
Clinical neurology and neurosurgery164132-137(2018 01)

Contextual tumor suppressor function of T cell death-associated gene 8 (TDAG8) in hematological malignancies.
Justus CR, Sanderlin EJ, Dong L, Sun T, Chi JT, Lertpiriyapong K, Yang LV
Journal of translational medicine15(1)204(2017 10)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following GPR65 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GPR65 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu22300	NM_003608.4 Latest version!	Homo sapiens G protein-coupled receptor 65 (GPR65), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$223.30 $319.00
View Old Accession Versions >>
OHu22300	NM_003608.3	Homo sapiens G protein-coupled receptor 65 (GPR65), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$223.30 $319.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GPR65 ( NM_003608.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_003599.2 Homo sapiens G protein-coupled receptor 65 (GPR65), mRNA.

Price & Availability↑

CloneID	OHu22300
Clone ID Related Accession (Same CDS sequence)	NM_003608.4 , NM_003608.3
Accession Version	NM_003608.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1014bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1561910400000
Organism	Homo sapiens(human)
Product	psychosine receptor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL157955.5. On Nov 22, 2018 this sequence version replaced NM_003608.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DA950973.1, SRR1803615.13159.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000267549.5/ ENSP00000267549.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAACAGCA CATGTATTGA AGAACAGCAT GACCTGGATC ACTATTTGTT TCCCATTGTT 
TACATCTTTG TGATTATAGT CAGCATTCCA GCCAATATTG GATCTCTGTG TGTGTCTTTC 
CTGCAAGCAA AGAAGGAAAG TGAACTAGGA ATTTACCTCT TCAGTTTGTC ACTATCAGAT 
TTACTCTATG CATTAACTCT CCCTTTATGG ATTGATTATA CCTGGAATAA AGACAACTGG 
ACTTTCTCTC CTGCCTTGTG CAAAGGGAGT GCTTTTCTCA TGTACATGAA TTTTTACAGC 
AGCACAGCAT TCCTCACCTG CATTGCCGTT GATCGGTATT TGGCTGTTGT CTACCCTTTG 
AAGTTTTTTT TCCTAAGGAC AAGAAGATTT GCACTCATGG TCAGCCTGTC CATCTGGATA 
TTGGAAACCA TCTTCAATGC TGTCATGTTG TGGGAAGATG AAACAGTTGT TGAATATTGC 
GATGCCGAAA AGTCTAATTT TACTTTATGC TATGACAAAT ACCCTTTAGA GAAATGGCAA 
ATCAACCTCA ACTTGTTCAG GACGTGTACA GGCTATGCAA TACCTTTGGT CACCATCCTG 
ATCTGCAACC GGAAAGTCTA CCAAGCTGTG CGGCACAATA AAGCCACGGA AAACAAGGAA 
AAGAAGAGAA TCATAAAACT ACTTGTCAGC ATCACAGTTA CTTTTGTCTT ATGCTTTACT 
CCCTTTCATG TGATGTTGCT GATTCGCTGC ATTTTAGAGC ATGCTGTGAA CTTCGAAGAC 
CACAGCAATT CTGGGAAGCG AACTTACACA ATGTATAGAA TCACGGTTGC ATTAACAAGT 
TTAAATTGTG TTGCTGATCC AATTCTGTAC TGTTTTGTAA CCGAAACAGG AAGATATGAT 
ATGTGGAATA TATTAAAATT CTGCACTGGG AGGTGTAATA CATCACAAAG ACAAAGAAAA 
CGCATACTTT CTGTGTCTAC AAAAGATACT ATGGAATTAG AGGTCCTTGA GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003599.2
CDS	548..1561
Translation	MNSTCIEEQHDLDHYLFPIVYIFVIIVSIPANIGSLCVSFLQAKKESELGIYLFSLSLSDLLYALTLPLWIDYTWNKDNWTFSPALCKGSAFLMYMNFYSSTAFLTCIAVDRYLAVVYPLKFFFLRTRRFALMVSLSIWILETIFNAVMLWEDETVVEYCDAEKSNFTLCYDKYPLEKWQINLNLFRTCTGYAIPLVTILICNRKVYQAVRHNKATENKEKKRIIKLLVSITVTFVLCFTPFHVMLLIRCILEHAVNFEDHSNSGKRTYTMYRITVALTSLNCVADPILYCFVTETGRYDMWNILKFCTGRCNTSQRQRKRILSVSTKDTMELEVLE

Target ORF information:

RefSeq Version	NM_003608.4
Organism	Homo sapiens(human)
Definition	Homo sapiens G protein-coupled receptor 65 (GPR65), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003608.4

ORF Insert Sequence:

ATGAACAGCA CATGTATTGA AGAACAGCAT GACCTGGATC ACTATTTGTT TCCCATTGTT 
TACATCTTTG TGATTATAGT CAGCATTCCA GCCAATATTG GATCTCTGTG TGTGTCTTTC 
CTGCAAGCAA AGAAGGAAAG TGAACTAGGA ATTTACCTCT TCAGTTTGTC ACTATCAGAT 
TTACTCTATG CATTAACTCT CCCTTTATGG ATTGATTATA CCTGGAATAA AGACAACTGG 
ACTTTCTCTC CTGCCTTGTG CAAAGGGAGT GCTTTTCTCA TGTACATGAA TTTTTACAGC 
AGCACAGCAT TCCTCACCTG CATTGCCGTT GATCGGTATT TGGCTGTTGT CTACCCTTTG 
AAGTTTTTTT TCCTAAGGAC AAGAAGATTT GCACTCATGG TCAGCCTGTC CATCTGGATA 
TTGGAAACCA TCTTCAATGC TGTCATGTTG TGGGAAGATG AAACAGTTGT TGAATATTGC 
GATGCCGAAA AGTCTAATTT TACTTTATGC TATGACAAAT ACCCTTTAGA GAAATGGCAA 
ATCAACCTCA ACTTGTTCAG GACGTGTACA GGCTATGCAA TACCTTTGGT CACCATCCTG 
ATCTGCAACC GGAAAGTCTA CCAAGCTGTG CGGCACAATA AAGCCACGGA AAACAAGGAA 
AAGAAGAGAA TCATAAAACT ACTTGTCAGC ATCACAGTTA CTTTTGTCTT ATGCTTTACT 
CCCTTTCATG TGATGTTGCT GATTCGCTGC ATTTTAGAGC ATGCTGTGAA CTTCGAAGAC 
CACAGCAATT CTGGGAAGCG AACTTACACA ATGTATAGAA TCACGGTTGC ATTAACAAGT 
TTAAATTGTG TTGCTGATCC AATTCTGTAC TGTTTTGTAA CCGAAACAGG AAGATATGAT 
ATGTGGAATA TATTAAAATT CTGCACTGGG AGGTGTAATA CATCACAAAG ACAAAGAAAA 
CGCATACTTT CTGTGTCTAC AAAAGATACT ATGGAATTAG AGGTCCTTGA GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GPR65 ( NM_003608.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003599.2 Homo sapiens G protein-coupled receptor 65 (GPR65), mRNA.

Price & Availability↑

CloneID	OHu22300
Clone ID Related Accession (Same CDS sequence)	NM_003608.4 , NM_003608.3
Accession Version	NM_003608.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1014bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1505577600000
Organism	Homo sapiens(human)
Product	psychosine receptor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL157955.5. On May 20, 2010 this sequence version replaced NM_003608.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.13159.1, SRR1163658.161432.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGAACAGCA CATGTATTGA AGAACAGCAT GACCTGGATC ACTATTTGTT TCCCATTGTT 
TACATCTTTG TGATTATAGT CAGCATTCCA GCCAATATTG GATCTCTGTG TGTGTCTTTC 
CTGCAAGCAA AGAAGGAAAG TGAACTAGGA ATTTACCTCT TCAGTTTGTC ACTATCAGAT 
TTACTCTATG CATTAACTCT CCCTTTATGG ATTGATTATA CCTGGAATAA AGACAACTGG 
ACTTTCTCTC CTGCCTTGTG CAAAGGGAGT GCTTTTCTCA TGTACATGAA TTTTTACAGC 
AGCACAGCAT TCCTCACCTG CATTGCCGTT GATCGGTATT TGGCTGTTGT CTACCCTTTG 
AAGTTTTTTT TCCTAAGGAC AAGAAGATTT GCACTCATGG TCAGCCTGTC CATCTGGATA 
TTGGAAACCA TCTTCAATGC TGTCATGTTG TGGGAAGATG AAACAGTTGT TGAATATTGC 
GATGCCGAAA AGTCTAATTT TACTTTATGC TATGACAAAT ACCCTTTAGA GAAATGGCAA 
ATCAACCTCA ACTTGTTCAG GACGTGTACA GGCTATGCAA TACCTTTGGT CACCATCCTG 
ATCTGCAACC GGAAAGTCTA CCAAGCTGTG CGGCACAATA AAGCCACGGA AAACAAGGAA 
AAGAAGAGAA TCATAAAACT ACTTGTCAGC ATCACAGTTA CTTTTGTCTT ATGCTTTACT 
CCCTTTCATG TGATGTTGCT GATTCGCTGC ATTTTAGAGC ATGCTGTGAA CTTCGAAGAC 
CACAGCAATT CTGGGAAGCG AACTTACACA ATGTATAGAA TCACGGTTGC ATTAACAAGT 
TTAAATTGTG TTGCTGATCC AATTCTGTAC TGTTTTGTAA CCGAAACAGG AAGATATGAT 
ATGTGGAATA TATTAAAATT CTGCACTGGG AGGTGTAATA CATCACAAAG ACAAAGAAAA 
CGCATACTTT CTGTGTCTAC AAAAGATACT ATGGAATTAG AGGTCCTTGA GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003599.2
CDS	559..1572
Translation	MNSTCIEEQHDLDHYLFPIVYIFVIIVSIPANIGSLCVSFLQAKKESELGIYLFSLSLSDLLYALTLPLWIDYTWNKDNWTFSPALCKGSAFLMYMNFYSSTAFLTCIAVDRYLAVVYPLKFFFLRTRRFALMVSLSIWILETIFNAVMLWEDETVVEYCDAEKSNFTLCYDKYPLEKWQINLNLFRTCTGYAIPLVTILICNRKVYQAVRHNKATENKEKKRIIKLLVSITVTFVLCFTPFHVMLLIRCILEHAVNFEDHSNSGKRTYTMYRITVALTSLNCVADPILYCFVTETGRYDMWNILKFCTGRCNTSQRQRKRILSVSTKDTMELEVLE

Target ORF information:

RefSeq Version	NM_003608.3
Organism	Homo sapiens(human)
Definition	Homo sapiens G protein-coupled receptor 65 (GPR65), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003608.3

ORF Insert Sequence:

ATGAACAGCA CATGTATTGA AGAACAGCAT GACCTGGATC ACTATTTGTT TCCCATTGTT 
TACATCTTTG TGATTATAGT CAGCATTCCA GCCAATATTG GATCTCTGTG TGTGTCTTTC 
CTGCAAGCAA AGAAGGAAAG TGAACTAGGA ATTTACCTCT TCAGTTTGTC ACTATCAGAT 
TTACTCTATG CATTAACTCT CCCTTTATGG ATTGATTATA CCTGGAATAA AGACAACTGG 
ACTTTCTCTC CTGCCTTGTG CAAAGGGAGT GCTTTTCTCA TGTACATGAA TTTTTACAGC 
AGCACAGCAT TCCTCACCTG CATTGCCGTT GATCGGTATT TGGCTGTTGT CTACCCTTTG 
AAGTTTTTTT TCCTAAGGAC AAGAAGATTT GCACTCATGG TCAGCCTGTC CATCTGGATA 
TTGGAAACCA TCTTCAATGC TGTCATGTTG TGGGAAGATG AAACAGTTGT TGAATATTGC 
GATGCCGAAA AGTCTAATTT TACTTTATGC TATGACAAAT ACCCTTTAGA GAAATGGCAA 
ATCAACCTCA ACTTGTTCAG GACGTGTACA GGCTATGCAA TACCTTTGGT CACCATCCTG 
ATCTGCAACC GGAAAGTCTA CCAAGCTGTG CGGCACAATA AAGCCACGGA AAACAAGGAA 
AAGAAGAGAA TCATAAAACT ACTTGTCAGC ATCACAGTTA CTTTTGTCTT ATGCTTTACT 
CCCTTTCATG TGATGTTGCT GATTCGCTGC ATTTTAGAGC ATGCTGTGAA CTTCGAAGAC 
CACAGCAATT CTGGGAAGCG AACTTACACA ATGTATAGAA TCACGGTTGC ATTAACAAGT 
TTAAATTGTG TTGCTGATCC AATTCTGTAC TGTTTTGTAA CCGAAACAGG AAGATATGAT 
ATGTGGAATA TATTAAAATT CTGCACTGGG AGGTGTAATA CATCACAAAG ACAAAGAAAA 
CGCATACTTT CTGTGTCTAC AAAAGATACT ATGGAATTAG AGGTCCTTGA GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genetic polymorphisms of G protein-coupled receptor 65 gene are associated with ankylosing spondylitis in a Chinese Han population: A case-control study.
Human immunology80(2)146-150(2019 Feb)
Yuan Y,Ma Y,Zhang X,Han R,Hu X,Yang J,Wang M,Guan SY,Pan G,Xu SQ,Jiang S,Pan F

The impact of the rs8005161 polymorphism on G protein-coupled receptor GPR65 (TDAG8) pH-associated activation in intestinal inflammation.
BMC gastroenterology19(1)2(2019 Jan)
Tcymbarevich IV,Eloranta JJ,Rossel JB,Obialo N,Spalinger M,Cosin-Roger J,Lang S,Kullak-Ublick GA,Wagner CA,Scharl M,Seuwen K,Ruiz PA,Rogler G,de Vallière C,Misselwitz B,

The role of acid-sensitive ion channels in panic disorder: a systematic review of animal studies and meta-analysis of human studies.
Translational psychiatry8(1)185(2018 09)
Quagliato LA,Freire RC,Nardi AE

Overexpression of G-protein-coupled receptors 65 in glioblastoma predicts poor patient prognosis.
Clinical neurology and neurosurgery164132-137(2018 01)
Wang HX,Chen YH,Zhou JX,Hu XY,Tan C,Yan Y,Huang QL,Shen JY,Xu HC,Li F,Gong ZY,Xu T,Chen JX

Contextual tumor suppressor function of T cell death-associated gene 8 (TDAG8) in hematological malignancies.
Journal of translational medicine15(1)204(2017 10)
Justus CR,Sanderlin EJ,Dong L,Sun T,Chi JT,Lertpiriyapong K,Yang LV

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GPR65 cDNA ORF clone, Homo sapiens(human)

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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