PCGF6 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PCGF6
Entrez Gene ID	84108
Full Name	polycomb group ring finger 6
Synonyms	MBLR,RNF134
General protein information	Preferred Names polycomb group ring finger 6 Names polycomb group RING finger protein 6 Mel18 and Bmi1-like RING finger protein ring finger protein 134
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10q24.33
Summary	The protein encoded by this gene contains a RING finger motif, which is most closely related to those of polycomb group (PcG) proteins RNF110/MEL-18 and BMI1. PcG proteins are known to form protein complexes and function as transcription repressors. This protein has been shown to interact with some PcG proteins and act as a transcription repressor. The activity of this protein is found to be regulated by cell cycle dependent phosphorylation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
Disorder MIM:	607816

mRNA and Protein(s)

mRNA	Protein	Name
NM_032154.3	NP_115530.2	polycomb group RING finger protein 6 isoform b
NM_032154.4	NP_115530.2	polycomb group RING finger protein 6 isoform b
NM_001011663.2	NP_001011663.1	polycomb group RING finger protein 6 isoform a
NM_001011663.1	NP_001011663.1	polycomb group RING finger protein 6 isoform a

Pathways from BioSystems

Homologies

Homo sapiens (human)	PCGF6	NP_001011663.1
Pan troglodytes (chimpanzee)	PCGF6	XP_508012.2
Mus musculus (house mouse)	Pcgf6	NP_081930.1
Xenopus tropicalis (tropical clawed frog)	pcgf6	XP_002936851.1
Macaca mulatta (Rhesus monkey)	PCGF6	XP_001113737.1
Gallus gallus (chicken)	PCGF6	XP_001234043.3
Bos taurus (cattle)	PCGF6	NP_001192549.1
Danio rerio (zebrafish)	pcgf6	NP_001082838.1
Canis lupus familiaris (dog)	PCGF6	XP_852021.1
Rattus norvegicus (Norway rat)	Pcgf6	NP_001013172.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

A High-Density Map for Navigating the Human Polycomb Complexome.
Hauri S, Comoglio F, Seimiya M, Gerstung M, Glatter T, Hansen K, Aebersold R, Paro R, Gstaiger M, Beisel C
Cell reports17(2)583-595(2016 10)

Polycomb Group Protein Pcgf6 Acts as a Master Regulator to Maintain Embryonic Stem Cell Identity.
Yang CS, Chang KY, Dang J, Rana TM
Scientific reports626899(2016 06)

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Hein MY, Hubner NC, Poser I, Cox J, Nagaraj N, Toyoda Y, Gak IA, Weisswange I, Mansfeld J, Buchholz F, Hyman AA, Mann M
Cell163(3)712-23(2015 Oct)

BMI1-RING1B is an autoinhibited RING E3 ubiquitin ligase.
Taherbhoy AM, Huang OW, Cochran AG
Nature communications67621(2015 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following PCGF6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PCGF6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17109	NM_032154.4 Latest version!	Homo sapiens polycomb group ring finger 6 (PCGF6), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu17118	NM_001011663.2 Latest version!	Homo sapiens polycomb group ring finger 6 (PCGF6), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$265.30 $379.00
View Old Accession Versions >>
OHu17109	NM_032154.3	Homo sapiens polycomb group ring finger 6 (PCGF6), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu17118	NM_001011663.1	Homo sapiens polycomb group ring finger 6 (PCGF6), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PCGF6 ( NM_032154.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_115530.2 Homo sapiens polycomb group ring finger 6 (PCGF6), transcript variant 2, mRNA.

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CloneID	OHu17109
Clone ID Related Accession (Same CDS sequence)	NM_032154.3 , NM_032154.4
Accession Version	NM_032154.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 828bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1550160000000
Organism	Homo sapiens(human)
Product	polycomb group RING finger protein 6 isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC010235.1 and BC007602.1. On Oct 14, 2003 this sequence version replaced NM_032154.2. Transcript Variant: This variant (2) lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (b), that is missing an internal segment compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC007602.1, SRR1803616.188980.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGGGGG TCGCGGTGGT GACGGCGGGC AGCGTAGGCG CTGCCAAAAC CGAGGGAGCT 
GCAGCCTTGC CGCCTCCGCC TCCTGTCTCC CCGCCCGCCC TCACCCCTGC ACCCGCAGCG 
GGTGAGGAGG GACCGGCGCC TCTGTCTGAG ACGGGGGCTC CCGGCTGCTC CGGCTCCCGG 
CCCCCTGAGC TGGAGCCGGA GCGCAGCCTG GGCCGCTTCA GAGGCCGCTT CGAGGACGAG 
GACGAGGAGT TGGAAGAAGA AGAGGAGCTG GAGGAGGAAG AAGAGGAGGA GGAGGAGGAC 
ATGAGTCACT TCTCGTTGAG GCTGGAGGGA GGCCGGCAGG ACTCGGAGGA CGAGGAGGAG 
CGCCTGATTA ATCTCTCTGA GCTGACCCCA TACATCTTGT GTTCCATTTG CAAAGGTTAC 
TTAATAGATG CAACTACCAT CACAGAATGT CTTCATACCT TTTGTAAAAG CTGCATCGTA 
AGACATTTTT ACTACAGCAA CAGATGTCCA AAATGCAATA TAGTAGTACA TCAGACACAA 
CCTCTTTATA ACATAAGTGC TAATGAAGGC ACGGGACATT TTAAGCCATT GGAAAAGAAG 
TTTGTTCGAG TTTCAGGAGA AGCAACTATT GGACATGTAG AAAAATTCCT CAGAAGAAAA 
ATGGGTCTTG ATCCAGCTTG TCAGGTAGAT ATAATCTGTG GTGATCACCT GTTGGAGCAG 
TATCAAACTC TAAGGGAAAT CCGACGTGCA ATAGGTGATG CAGCAATGCA GGATGGTCTG 
CTTGTCCTTC ATTATGGTCT TGTGGTTTCT CCTCTGAAGA TAACTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_115530.2
CDS	69..896
Translation	MEGVAVVTAGSVGAAKTEGAAALPPPPPVSPPALTPAPAAGEEGPAPLSETGAPGCSGSRPPELEPERSLGRFRGRFEDEDEELEEEEELEEEEEEEEEDMSHFSLRLEGGRQDSEDEEERLINLSELTPYILCSICKGYLIDATTITECLHTFCKSCIVRHFYYSNRCPKCNIVVHQTQPLYNISANEGTGHFKPLEKKFVRVSGEATIGHVEKFLRRKMGLDPACQVDIICGDHLLEQYQTLREIRRAIGDAAMQDGLLVLHYGLVVSPLKIT

Target ORF information:

RefSeq Version	NM_032154.3
Organism	Homo sapiens(human)
Definition	Homo sapiens polycomb group ring finger 6 (PCGF6), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032154.3

ORF Insert Sequence:

ATGGAGGGGG TCGCGGTGGT GACGGCGGGC AGCGTAGGCG CTGCCAAAAC CGAGGGAGCT 
GCAGCCTTGC CGCCTCCGCC TCCTGTCTCC CCGCCCGCCC TCACCCCTGC ACCCGCAGCG 
GGTGAGGAGG GACCGGCGCC TCTGTCTGAG ACGGGGGCTC CCGGCTGCTC CGGCTCCCGG 
CCCCCTGAGC TGGAGCCGGA GCGCAGCCTG GGCCGCTTCA GAGGCCGCTT CGAGGACGAG 
GACGAGGAGT TGGAAGAAGA AGAGGAGCTG GAGGAGGAAG AAGAGGAGGA GGAGGAGGAC 
ATGAGTCACT TCTCGTTGAG GCTGGAGGGA GGCCGGCAGG ACTCGGAGGA CGAGGAGGAG 
CGCCTGATTA ATCTCTCTGA GCTGACCCCA TACATCTTGT GTTCCATTTG CAAAGGTTAC 
TTAATAGATG CAACTACCAT CACAGAATGT CTTCATACCT TTTGTAAAAG CTGCATCGTA 
AGACATTTTT ACTACAGCAA CAGATGTCCA AAATGCAATA TAGTAGTACA TCAGACACAA 
CCTCTTTATA ACATAAGTGC TAATGAAGGC ACGGGACATT TTAAGCCATT GGAAAAGAAG 
TTTGTTCGAG TTTCAGGAGA AGCAACTATT GGACATGTAG AAAAATTCCT CAGAAGAAAA 
ATGGGTCTTG ATCCAGCTTG TCAGGTAGAT ATAATCTGTG GTGATCACCT GTTGGAGCAG 
TATCAAACTC TAAGGGAAAT CCGACGTGCA ATAGGTGATG CAGCAATGCA GGATGGTCTG 
CTTGTCCTTC ATTATGGTCT TGTGGTTTCT CCTCTGAAGA TAACTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PCGF6 ( NM_032154.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_115530.2 Homo sapiens polycomb group ring finger 6 (PCGF6), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu17109
Clone ID Related Accession (Same CDS sequence)	NM_032154.3 , NM_032154.4
Accession Version	NM_032154.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 828bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577980800000
Organism	Homo sapiens(human)
Product	polycomb group RING finger protein 6 isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL591408.19, BC010235.1 and BC007602.1. On May 31, 2019 this sequence version replaced NM_032154.3. Transcript Variant: This variant (2) lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (b), that is missing an internal segment compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC007602.1, SRR1803616.188980.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGGGGG TCGCGGTGGT GACGGCGGGC AGCGTAGGCG CTGCCAAAAC CGAGGGAGCT 
GCAGCCTTGC CGCCTCCGCC TCCTGTCTCC CCGCCCGCCC TCACCCCTGC ACCCGCAGCG 
GGTGAGGAGG GACCGGCGCC TCTGTCTGAG ACGGGGGCTC CCGGCTGCTC CGGCTCCCGG 
CCCCCTGAGC TGGAGCCGGA GCGCAGCCTG GGCCGCTTCA GAGGCCGCTT CGAGGACGAG 
GACGAGGAGT TGGAAGAAGA AGAGGAGCTG GAGGAGGAAG AAGAGGAGGA GGAGGAGGAC 
ATGAGTCACT TCTCGTTGAG GCTGGAGGGA GGCCGGCAGG ACTCGGAGGA CGAGGAGGAG 
CGCCTGATTA ATCTCTCTGA GCTGACCCCA TACATCTTGT GTTCCATTTG CAAAGGTTAC 
TTAATAGATG CAACTACCAT CACAGAATGT CTTCATACCT TTTGTAAAAG CTGCATCGTA 
AGACATTTTT ACTACAGCAA CAGATGTCCA AAATGCAATA TAGTAGTACA TCAGACACAA 
CCTCTTTATA ACATAAGTGC TAATGAAGGC ACGGGACATT TTAAGCCATT GGAAAAGAAG 
TTTGTTCGAG TTTCAGGAGA AGCAACTATT GGACATGTAG AAAAATTCCT CAGAAGAAAA 
ATGGGTCTTG ATCCAGCTTG TCAGGTAGAT ATAATCTGTG GTGATCACCT GTTGGAGCAG 
TATCAAACTC TAAGGGAAAT CCGACGTGCA ATAGGTGATG CAGCAATGCA GGATGGTCTG 
CTTGTCCTTC ATTATGGTCT TGTGGTTTCT CCTCTGAAGA TAACTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_115530.2
CDS	75..902
Translation	MEGVAVVTAGSVGAAKTEGAAALPPPPPVSPPALTPAPAAGEEGPAPLSETGAPGCSGSRPPELEPERSLGRFRGRFEDEDEELEEEEELEEEEEEEEEDMSHFSLRLEGGRQDSEDEEERLINLSELTPYILCSICKGYLIDATTITECLHTFCKSCIVRHFYYSNRCPKCNIVVHQTQPLYNISANEGTGHFKPLEKKFVRVSGEATIGHVEKFLRRKMGLDPACQVDIICGDHLLEQYQTLREIRRAIGDAAMQDGLLVLHYGLVVSPLKIT

Target ORF information:

RefSeq Version	NM_032154.4
Organism	Homo sapiens(human)
Definition	Homo sapiens polycomb group ring finger 6 (PCGF6), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032154.4

ORF Insert Sequence:

ATGGAGGGGG TCGCGGTGGT GACGGCGGGC AGCGTAGGCG CTGCCAAAAC CGAGGGAGCT 
GCAGCCTTGC CGCCTCCGCC TCCTGTCTCC CCGCCCGCCC TCACCCCTGC ACCCGCAGCG 
GGTGAGGAGG GACCGGCGCC TCTGTCTGAG ACGGGGGCTC CCGGCTGCTC CGGCTCCCGG 
CCCCCTGAGC TGGAGCCGGA GCGCAGCCTG GGCCGCTTCA GAGGCCGCTT CGAGGACGAG 
GACGAGGAGT TGGAAGAAGA AGAGGAGCTG GAGGAGGAAG AAGAGGAGGA GGAGGAGGAC 
ATGAGTCACT TCTCGTTGAG GCTGGAGGGA GGCCGGCAGG ACTCGGAGGA CGAGGAGGAG 
CGCCTGATTA ATCTCTCTGA GCTGACCCCA TACATCTTGT GTTCCATTTG CAAAGGTTAC 
TTAATAGATG CAACTACCAT CACAGAATGT CTTCATACCT TTTGTAAAAG CTGCATCGTA 
AGACATTTTT ACTACAGCAA CAGATGTCCA AAATGCAATA TAGTAGTACA TCAGACACAA 
CCTCTTTATA ACATAAGTGC TAATGAAGGC ACGGGACATT TTAAGCCATT GGAAAAGAAG 
TTTGTTCGAG TTTCAGGAGA AGCAACTATT GGACATGTAG AAAAATTCCT CAGAAGAAAA 
ATGGGTCTTG ATCCAGCTTG TCAGGTAGAT ATAATCTGTG GTGATCACCT GTTGGAGCAG 
TATCAAACTC TAAGGGAAAT CCGACGTGCA ATAGGTGATG CAGCAATGCA GGATGGTCTG 
CTTGTCCTTC ATTATGGTCT TGTGGTTTCT CCTCTGAAGA TAACTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PCGF6 ( NM_001011663.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001011663.1 Homo sapiens polycomb group ring finger 6 (PCGF6), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu17118
Clone ID Related Accession (Same CDS sequence)	NM_001011663.2 , NM_001011663.1
Accession Version	NM_001011663.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1053bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577635200000
Organism	Homo sapiens(human)
Product	polycomb group RING finger protein 6 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL591408.19, BC010235.1 and BC007602.1. On Nov 22, 2018 this sequence version replaced NM_001011663.1. Transcript Variant: This variant (1) represents the longer transcript, and encodes the longer isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC010235.1, SRR1660809.187491.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000369847.4/ ENSP00000358862.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGGGGG TCGCGGTGGT GACGGCGGGC AGCGTAGGCG CTGCCAAAAC CGAGGGAGCT 
GCAGCCTTGC CGCCTCCGCC TCCTGTCTCC CCGCCCGCCC TCACCCCTGC ACCCGCAGCG 
GGTGAGGAGG GACCGGCGCC TCTGTCTGAG ACGGGGGCTC CCGGCTGCTC CGGCTCCCGG 
CCCCCTGAGC TGGAGCCGGA GCGCAGCCTG GGCCGCTTCA GAGGCCGCTT CGAGGACGAG 
GACGAGGAGT TGGAAGAAGA AGAGGAGCTG GAGGAGGAAG AAGAGGAGGA GGAGGAGGAC 
ATGAGTCACT TCTCGTTGAG GCTGGAGGGA GGCCGGCAGG ACTCGGAGGA CGAGGAGGAG 
CGCCTGATTA ATCTCTCTGA GCTGACCCCA TACATCTTGT GTTCCATTTG CAAAGGTTAC 
TTAATAGATG CAACTACCAT CACAGAATGT CTTCATACCT TTTGTAAAAG CTGCATCGTA 
AGACATTTTT ACTACAGCAA CAGATGTCCA AAATGCAATA TAGTAGTACA TCAGACACAA 
CCTCTTTATA ACATAAGGTT GGACCGACAG TTACAAGACA TAGTGTACAA ATTAGTGATC 
AATCTAGAGG AAAGAGAAAA AAAGCAAATG CATGATTTCT ATAAAGAAAG AGGTCTAGAA 
GTACCTAAAC CTGCTGTTCC ACAGCCAGTC CCTTCAAGCA AAGGAAGATC TAAAAAAGTC 
CTAGAATCAG TGTTTCGTAT TCCACCTGAA CTTGATATGT CTTTATTACT GGAGTTCATT 
GGTGCTAATG AAGGCACGGG ACATTTTAAG CCATTGGAAA AGAAGTTTGT TCGAGTTTCA 
GGAGAAGCAA CTATTGGACA TGTAGAAAAA TTCCTCAGAA GAAAAATGGG TCTTGATCCA 
GCTTGTCAGG TAGATATAAT CTGTGGTGAT CACCTGTTGG AGCAGTATCA AACTCTAAGG 
GAAATCCGAC GTGCAATAGG TGATGCAGCA ATGCAGGATG GTCTGCTTGT CCTTCATTAT 
GGTCTTGTGG TTTCTCCTCT GAAGATAACT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001011663.1
CDS	75..1127
Translation	MEGVAVVTAGSVGAAKTEGAAALPPPPPVSPPALTPAPAAGEEGPAPLSETGAPGCSGSRPPELEPERSLGRFRGRFEDEDEELEEEEELEEEEEEEEEDMSHFSLRLEGGRQDSEDEEERLINLSELTPYILCSICKGYLIDATTITECLHTFCKSCIVRHFYYSNRCPKCNIVVHQTQPLYNIRLDRQLQDIVYKLVINLEEREKKQMHDFYKERGLEVPKPAVPQPVPSSKGRSKKVLESVFRIPPELDMSLLLEFIGANEGTGHFKPLEKKFVRVSGEATIGHVEKFLRRKMGLDPACQVDIICGDHLLEQYQTLREIRRAIGDAAMQDGLLVLHYGLVVSPLKIT

Target ORF information:

RefSeq Version	NM_001011663.2
Organism	Homo sapiens(human)
Definition	Homo sapiens polycomb group ring finger 6 (PCGF6), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001011663.2

ORF Insert Sequence:

ATGGAGGGGG TCGCGGTGGT GACGGCGGGC AGCGTAGGCG CTGCCAAAAC CGAGGGAGCT 
GCAGCCTTGC CGCCTCCGCC TCCTGTCTCC CCGCCCGCCC TCACCCCTGC ACCCGCAGCG 
GGTGAGGAGG GACCGGCGCC TCTGTCTGAG ACGGGGGCTC CCGGCTGCTC CGGCTCCCGG 
CCCCCTGAGC TGGAGCCGGA GCGCAGCCTG GGCCGCTTCA GAGGCCGCTT CGAGGACGAG 
GACGAGGAGT TGGAAGAAGA AGAGGAGCTG GAGGAGGAAG AAGAGGAGGA GGAGGAGGAC 
ATGAGTCACT TCTCGTTGAG GCTGGAGGGA GGCCGGCAGG ACTCGGAGGA CGAGGAGGAG 
CGCCTGATTA ATCTCTCTGA GCTGACCCCA TACATCTTGT GTTCCATTTG CAAAGGTTAC 
TTAATAGATG CAACTACCAT CACAGAATGT CTTCATACCT TTTGTAAAAG CTGCATCGTA 
AGACATTTTT ACTACAGCAA CAGATGTCCA AAATGCAATA TAGTAGTACA TCAGACACAA 
CCTCTTTATA ACATAAGGTT GGACCGACAG TTACAAGACA TAGTGTACAA ATTAGTGATC 
AATCTAGAGG AAAGAGAAAA AAAGCAAATG CATGATTTCT ATAAAGAAAG AGGTCTAGAA 
GTACCTAAAC CTGCTGTTCC ACAGCCAGTC CCTTCAAGCA AAGGAAGATC TAAAAAAGTC 
CTAGAATCAG TGTTTCGTAT TCCACCTGAA CTTGATATGT CTTTATTACT GGAGTTCATT 
GGTGCTAATG AAGGCACGGG ACATTTTAAG CCATTGGAAA AGAAGTTTGT TCGAGTTTCA 
GGAGAAGCAA CTATTGGACA TGTAGAAAAA TTCCTCAGAA GAAAAATGGG TCTTGATCCA 
GCTTGTCAGG TAGATATAAT CTGTGGTGAT CACCTGTTGG AGCAGTATCA AACTCTAAGG 
GAAATCCGAC GTGCAATAGG TGATGCAGCA ATGCAGGATG GTCTGCTTGT CCTTCATTAT 
GGTCTTGTGG TTTCTCCTCT GAAGATAACT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PCGF6 ( NM_001011663.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001011663.1 Homo sapiens polycomb group ring finger 6 (PCGF6), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu17118
Clone ID Related Accession (Same CDS sequence)	NM_001011663.2 , NM_001011663.1
Accession Version	NM_001011663.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1053bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1514217600000
Organism	Homo sapiens(human)
Product	polycomb group RING finger protein 6 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC010235.1 and BC007602.1. Transcript Variant: This variant (1) represents the longer transcript, and encodes the longer isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC010235.1, SRR1660809.187491.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGGGGG TCGCGGTGGT GACGGCGGGC AGCGTAGGCG CTGCCAAAAC CGAGGGAGCT 
GCAGCCTTGC CGCCTCCGCC TCCTGTCTCC CCGCCCGCCC TCACCCCTGC ACCCGCAGCG 
GGTGAGGAGG GACCGGCGCC TCTGTCTGAG ACGGGGGCTC CCGGCTGCTC CGGCTCCCGG 
CCCCCTGAGC TGGAGCCGGA GCGCAGCCTG GGCCGCTTCA GAGGCCGCTT CGAGGACGAG 
GACGAGGAGT TGGAAGAAGA AGAGGAGCTG GAGGAGGAAG AAGAGGAGGA GGAGGAGGAC 
ATGAGTCACT TCTCGTTGAG GCTGGAGGGA GGCCGGCAGG ACTCGGAGGA CGAGGAGGAG 
CGCCTGATTA ATCTCTCTGA GCTGACCCCA TACATCTTGT GTTCCATTTG CAAAGGTTAC 
TTAATAGATG CAACTACCAT CACAGAATGT CTTCATACCT TTTGTAAAAG CTGCATCGTA 
AGACATTTTT ACTACAGCAA CAGATGTCCA AAATGCAATA TAGTAGTACA TCAGACACAA 
CCTCTTTATA ACATAAGGTT GGACCGACAG TTACAAGACA TAGTGTACAA ATTAGTGATC 
AATCTAGAGG AAAGAGAAAA AAAGCAAATG CATGATTTCT ATAAAGAAAG AGGTCTAGAA 
GTACCTAAAC CTGCTGTTCC ACAGCCAGTC CCTTCAAGCA AAGGAAGATC TAAAAAAGTC 
CTAGAATCAG TGTTTCGTAT TCCACCTGAA CTTGATATGT CTTTATTACT GGAGTTCATT 
GGTGCTAATG AAGGCACGGG ACATTTTAAG CCATTGGAAA AGAAGTTTGT TCGAGTTTCA 
GGAGAAGCAA CTATTGGACA TGTAGAAAAA TTCCTCAGAA GAAAAATGGG TCTTGATCCA 
GCTTGTCAGG TAGATATAAT CTGTGGTGAT CACCTGTTGG AGCAGTATCA AACTCTAAGG 
GAAATCCGAC GTGCAATAGG TGATGCAGCA ATGCAGGATG GTCTGCTTGT CCTTCATTAT 
GGTCTTGTGG TTTCTCCTCT GAAGATAACT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001011663.1
CDS	69..1121
Translation	MEGVAVVTAGSVGAAKTEGAAALPPPPPVSPPALTPAPAAGEEGPAPLSETGAPGCSGSRPPELEPERSLGRFRGRFEDEDEELEEEEELEEEEEEEEEDMSHFSLRLEGGRQDSEDEEERLINLSELTPYILCSICKGYLIDATTITECLHTFCKSCIVRHFYYSNRCPKCNIVVHQTQPLYNIRLDRQLQDIVYKLVINLEEREKKQMHDFYKERGLEVPKPAVPQPVPSSKGRSKKVLESVFRIPPELDMSLLLEFIGANEGTGHFKPLEKKFVRVSGEATIGHVEKFLRRKMGLDPACQVDIICGDHLLEQYQTLREIRRAIGDAAMQDGLLVLHYGLVVSPLKIT

Target ORF information:

RefSeq Version	NM_001011663.1
Organism	Homo sapiens(human)
Definition	Homo sapiens polycomb group ring finger 6 (PCGF6), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001011663.1

ORF Insert Sequence:

ATGGAGGGGG TCGCGGTGGT GACGGCGGGC AGCGTAGGCG CTGCCAAAAC CGAGGGAGCT 
GCAGCCTTGC CGCCTCCGCC TCCTGTCTCC CCGCCCGCCC TCACCCCTGC ACCCGCAGCG 
GGTGAGGAGG GACCGGCGCC TCTGTCTGAG ACGGGGGCTC CCGGCTGCTC CGGCTCCCGG 
CCCCCTGAGC TGGAGCCGGA GCGCAGCCTG GGCCGCTTCA GAGGCCGCTT CGAGGACGAG 
GACGAGGAGT TGGAAGAAGA AGAGGAGCTG GAGGAGGAAG AAGAGGAGGA GGAGGAGGAC 
ATGAGTCACT TCTCGTTGAG GCTGGAGGGA GGCCGGCAGG ACTCGGAGGA CGAGGAGGAG 
CGCCTGATTA ATCTCTCTGA GCTGACCCCA TACATCTTGT GTTCCATTTG CAAAGGTTAC 
TTAATAGATG CAACTACCAT CACAGAATGT CTTCATACCT TTTGTAAAAG CTGCATCGTA 
AGACATTTTT ACTACAGCAA CAGATGTCCA AAATGCAATA TAGTAGTACA TCAGACACAA 
CCTCTTTATA ACATAAGGTT GGACCGACAG TTACAAGACA TAGTGTACAA ATTAGTGATC 
AATCTAGAGG AAAGAGAAAA AAAGCAAATG CATGATTTCT ATAAAGAAAG AGGTCTAGAA 
GTACCTAAAC CTGCTGTTCC ACAGCCAGTC CCTTCAAGCA AAGGAAGATC TAAAAAAGTC 
CTAGAATCAG TGTTTCGTAT TCCACCTGAA CTTGATATGT CTTTATTACT GGAGTTCATT 
GGTGCTAATG AAGGCACGGG ACATTTTAAG CCATTGGAAA AGAAGTTTGT TCGAGTTTCA 
GGAGAAGCAA CTATTGGACA TGTAGAAAAA TTCCTCAGAA GAAAAATGGG TCTTGATCCA 
GCTTGTCAGG TAGATATAAT CTGTGGTGAT CACCTGTTGG AGCAGTATCA AACTCTAAGG 
GAAATCCGAC GTGCAATAGG TGATGCAGCA ATGCAGGATG GTCTGCTTGT CCTTCATTAT 
GGTCTTGTGG TTTCTCCTCT GAAGATAACT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

A High-Density Map for Navigating the Human Polycomb Complexome.
Cell reports17(2)583-595(2016 10)
Hauri S,Comoglio F,Seimiya M,Gerstung M,Glatter T,Hansen K,Aebersold R,Paro R,Gstaiger M,Beisel C

Polycomb Group Protein Pcgf6 Acts as a Master Regulator to Maintain Embryonic Stem Cell Identity.
Scientific reports626899(2016 06)
Yang CS,Chang KY,Dang J,Rana TM

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Cell163(3)712-23(2015 Oct)
Hein MY,Hubner NC,Poser I,Cox J,Nagaraj N,Toyoda Y,Gak IA,Weisswange I,Mansfeld J,Buchholz F,Hyman AA,Mann M

BMI1-RING1B is an autoinhibited RING E3 ubiquitin ligase.
Nature communications67621(2015 Jul)
Taherbhoy AM,Huang OW,Cochran AG

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PCGF6 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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