| Gene Symbol | RRAS |
| Entrez Gene ID | 6237 |
| Full Name | RAS related |
| Synonyms | R-Ras |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | The protein encoded by this gene is a small GTPase involved in diverse processes including angiogenesis, vascular homeostasis and regeneration, cell adhesion, and neuronal axon guidance. Mutations in this gene are found in many invasive cancers. [provided by RefSeq, Jul 2015]. |
| Disorder MIM: |
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RRAS cDNA ORF clone, Homo sapiens(human)
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Gene
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Clones
gRNAs
The following RRAS gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RRAS cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OHu25972 Clone ID Related Accession (Same CDS sequence) NM_006270.4 , NM_006270.5 Accession Version NM_006270.4 Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 657bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1501776000000 Organism Homo sapiens(human) Product ras-related protein R-Ras Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC016318.1 and BC016286.1. This sequence is a reference standard in the RefSeqGene project. On Jul 8, 2015 this sequence version replaced NM_006270.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC016286.1, BC016318.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.
1
61
121
181
241
301
361
421
481
541
601ATGAGCAGCG GGGCGGCGTC CGGGACAGGG CGGGGGCGGC CCCGGGGCGG GGGACCTGGG
CCCGGGGACC CCCCGCCCAG CGAGACACAC AAGCTGGTGG TCGTGGGCGG CGGCGGCGTG
GGCAAGAGCG CGCTGACCAT CCAGTTCATC CAGTCCTACT TCGTGTCTGA CTACGACCCC
ACTATTGAGG ACTCCTACAC GAAGATCTGC AGTGTGGATG GCATCCCAGC CCGGCTGGAC
ATCCTGGACA CCGCGGGCCA GGAAGAGTTC GGGGCCATGA GAGAGCAGTA CATGCGTGCT
GGCCACGGCT TCCTGCTGGT GTTCGCCATT AACGACCGGC AGAGTTTCAA CGAGGTGGGC
AAGCTCTTCA CGCAGATTCT GCGGGTCAAG GACCGCGACG ACTTCCCCGT TGTGTTGGTC
GGGAACAAGG CAGATCTGGA GTCACAGCGC CAGGTCCCCC GATCAGAAGC CTCTGCCTTC
GGCGCCTCCC ACCACGTGGC CTACTTTGAG GCCTCGGCCA AACTGCGTCT CAACGTGGAC
GAGGCTTTTG AGCAGCTGGT GCGGGCTGTC CGGAAATACC AGGAACAAGA GCTCCCACCG
AGCCCTCCCA GTGCCCCCAG GAAGAAGGGC GGGGGCTGCC CCTGCGTCCT CCTGTAGThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_006261.1 CDS 46..702 Translation 
Target ORF information:
RefSeq Version NM_006270.4 Organism Homo sapiens(human) Definition Homo sapiens RAS related (RRAS), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_006270.4
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601ATGAGCAGCG GGGCGGCGTC CGGGACAGGG CGGGGGCGGC CCCGGGGCGG GGGACCTGGG
CCCGGGGACC CCCCGCCCAG CGAGACACAC AAGCTGGTGG TCGTGGGCGG CGGCGGCGTG
GGCAAGAGCG CGCTGACCAT CCAGTTCATC CAGTCCTACT TCGTGTCTGA CTACGACCCC
ACTATTGAGG ACTCCTACAC GAAGATCTGC AGTGTGGATG GCATCCCAGC CCGGCTGGAC
ATCCTGGACA CCGCGGGCCA GGAAGAGTTC GGGGCCATGA GAGAGCAGTA CATGCGTGCT
GGCCACGGCT TCCTGCTGGT GTTCGCCATT AACGACCGGC AGAGTTTCAA CGAGGTGGGC
AAGCTCTTCA CGCAGATTCT GCGGGTCAAG GACCGCGACG ACTTCCCCGT TGTGTTGGTC
GGGAACAAGG CAGATCTGGA GTCACAGCGC CAGGTCCCCC GATCAGAAGC CTCTGCCTTC
GGCGCCTCCC ACCACGTGGC CTACTTTGAG GCCTCGGCCA AACTGCGTCT CAACGTGGAC
GAGGCTTTTG AGCAGCTGGT GCGGGCTGTC CGGAAATACC AGGAACAAGA GCTCCCACCG
AGCCCTCCCA GTGCCCCCAG GAAGAAGGGC GGGGGCTGCC CCTGCGTCCT CCTGTAGThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OHu25972 Clone ID Related Accession (Same CDS sequence) NM_006270.4 , NM_006270.5 Accession Version NM_006270.5 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 657bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1566316800000 Organism Homo sapiens(human) Product ras-related protein R-Ras Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC016318.1 and BC016286.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_006270.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC016286.1, BC016318.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000246792.4/ ENSP00000246792.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.
1
61
121
181
241
301
361
421
481
541
601ATGAGCAGCG GGGCGGCGTC CGGGACAGGG CGGGGGCGGC CCCGGGGCGG GGGACCTGGG
CCCGGGGACC CCCCGCCCAG CGAGACACAC AAGCTGGTGG TCGTGGGCGG CGGCGGCGTG
GGCAAGAGCG CGCTGACCAT CCAGTTCATC CAGTCCTACT TCGTGTCTGA CTACGACCCC
ACTATTGAGG ACTCCTACAC GAAGATCTGC AGTGTGGATG GCATCCCAGC CCGGCTGGAC
ATCCTGGACA CCGCGGGCCA GGAAGAGTTC GGGGCCATGA GAGAGCAGTA CATGCGTGCT
GGCCACGGCT TCCTGCTGGT GTTCGCCATT AACGACCGGC AGAGTTTCAA CGAGGTGGGC
AAGCTCTTCA CGCAGATTCT GCGGGTCAAG GACCGCGACG ACTTCCCCGT TGTGTTGGTC
GGGAACAAGG CAGATCTGGA GTCACAGCGC CAGGTCCCCC GATCAGAAGC CTCTGCCTTC
GGCGCCTCCC ACCACGTGGC CTACTTTGAG GCCTCGGCCA AACTGCGTCT CAACGTGGAC
GAGGCTTTTG AGCAGCTGGT GCGGGCTGTC CGGAAATACC AGGAACAAGA GCTCCCACCG
AGCCCTCCCA GTGCCCCCAG GAAGAAGGGC GGGGGCTGCC CCTGCGTCCT CCTGTAGThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_006261.1 CDS 46..702 Translation
Target ORF information:
RefSeq Version NM_006270.5 Organism Homo sapiens(human) Definition Homo sapiens RAS related (RRAS), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK NM_006270.5
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601ATGAGCAGCG GGGCGGCGTC CGGGACAGGG CGGGGGCGGC CCCGGGGCGG GGGACCTGGG
CCCGGGGACC CCCCGCCCAG CGAGACACAC AAGCTGGTGG TCGTGGGCGG CGGCGGCGTG
GGCAAGAGCG CGCTGACCAT CCAGTTCATC CAGTCCTACT TCGTGTCTGA CTACGACCCC
ACTATTGAGG ACTCCTACAC GAAGATCTGC AGTGTGGATG GCATCCCAGC CCGGCTGGAC
ATCCTGGACA CCGCGGGCCA GGAAGAGTTC GGGGCCATGA GAGAGCAGTA CATGCGTGCT
GGCCACGGCT TCCTGCTGGT GTTCGCCATT AACGACCGGC AGAGTTTCAA CGAGGTGGGC
AAGCTCTTCA CGCAGATTCT GCGGGTCAAG GACCGCGACG ACTTCCCCGT TGTGTTGGTC
GGGAACAAGG CAGATCTGGA GTCACAGCGC CAGGTCCCCC GATCAGAAGC CTCTGCCTTC
GGCGCCTCCC ACCACGTGGC CTACTTTGAG GCCTCGGCCA AACTGCGTCT CAACGTGGAC
GAGGCTTTTG AGCAGCTGGT GCGGGCTGTC CGGAAATACC AGGAACAAGA GCTCCCACCG
AGCCCTCCCA GTGCCCCCAG GAAGAAGGGC GGGGGCTGCC CCTGCGTCCT CCTGTAGThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras.
Nature cell biology19(4)292-305(2017 04)
Lilja J,Zacharchenko T,Georgiadou M,Jacquemet G,De Franceschi N,Peuhu E,Hamidi H,Pouwels J,Martens V,Nia FH,Beifuss M,Boeckers T,Kreienkamp HJ,Barsukov IL,Ivaska J
Quantitative proteomics reveals that distant recurrence-associated protein R-Ras and Transgelin predict post-surgical survival in patients with Stage III colorectal cancer.
Oncotarget7(28)43868-43893(2016 Jul)
Xu L,Gao Y,Chen Y,Xiao Y,He Q,Qiu H,Ge W
Inactivation of RASA1 promotes melanoma tumorigenesis via R-Ras activation.
Oncotarget7(17)23885-96(2016 Apr)
Sung H,Kanchi KL,Wang X,Hill KS,Messina JL,Lee JH,Kim Y,Dees ND,Ding L,Teer JK,Yang S,Sarnaik AA,Sondak VK,Mulé JJ,Wilson RK,Weber JS,Kim M
miR-34/449 control apical actin network formation during multiciliogenesis through small GTPase pathways.
Nature communications68386(2015 Sep)
Chevalier B,Adamiok A,Mercey O,Revinski DR,Zaragosi LE,Pasini A,Kodjabachian L,Barbry P,Marcet B
R-Ras Inhibits VEGF-Induced p38MAPK Activation and HSP27 Phosphorylation in Endothelial Cells.
Journal of vascular research52(5)347-59(2015)
Sawada J,Li F,Komatsu M
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