| Gene Symbol | AS3MT |
| Entrez Gene ID | 57412 |
| Full Name | arsenite methyltransferase |
| Synonyms | CYT19 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | AS3MT catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to trivalent arsenical and may play a role in arsenic metabolism (Lin et al., 2002 [PubMed 11790780]).[supplied by OMIM, Mar 2008]. |
| Disorder MIM: |
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AS3MT cDNA ORF clone, Homo sapiens(human)
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Gene
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Clones
gRNAs
The following AS3MT gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the AS3MT cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OHu24551 Clone ID Related Accession (Same CDS sequence) NM_020682.4 , NM_020682.3 Accession Version NM_020682.4 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 1128bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1556640000000 Organism Homo sapiens(human) Product arsenite methyltransferase Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA368970.1, BC119638.2, AL358790.22 and AW139845.1. On Nov 23, 2018 this sequence version replaced NM_020682.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.53989.1, SRR3476690.844720.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000369880.8/ ENSP00000358896.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081ATGGCTGCAC TTCGTGACGC TGAGATACAG AAGGACGTGC AGACCTACTA CGGGCAGGTG
CTGAAGAGAT CGGCAGACCT CCAGACCAAC GGCTGTGTCA CCACAGCCAG GCCGGTCCCC
AAGCACATCC GGGAAGCCTT GCAAAATGTA CACGAAGAAG TAGCCCTAAG ATATTATGGC
TGTGGTCTGG TGATCCCTGA GCATCTAGAA AACTGCTGGA TTTTGGATCT GGGTAGTGGA
AGTGGCAGAG ATTGCTATGT ACTTAGCCAG CTGGTTGGTG AAAAAGGACA CGTGACTGGA
ATAGACATGA CCAAAGGCCA GGTGGAAGTG GCTGAAAAGT ATCTTGACTA TCACATGGAA
AAATATGGCT TCCAGGCATC TAATGTGACT TTTATTCATG GCTACATTGA GAAGTTGGGA
GAGGCTGGAA TCAAGAATGA GAGCCATGAT ATTGTTGTAT CAAACTGTGT TATTAACCTT
GTGCCTGATA AACAACAAGT GCTTCAGGAG GCATATCGGG TGCTGAAGCA TGGTGGGGAG
TTATATTTCA GTGACGTCTA TACGAGCCTT GAACTGCCAG AAGAAATCAG GACACACAAA
GTTTTATGGG GTGAGTGTCT GGGTGGTGCT TTATACTGGA AGGAACTTGC TGTCCTTGCT
CAAAAAATTG GGTTCTGCCC TCCACGTTTG GTCACTGCCA ATCTCATTAC AATTCAAAAC
AAGGAACTGG AAAGAGTTAT CGGTGACTGT CGTTTTGTTT CTGCAACATT TCGCCTCTTC
AAACACTCTA AGACAGGACC AACCAAGAGA TGCCAAGTTA TTTACAATGG AGGAATTACA
GGACATGAAA AAGAACTAAT GTTTGATGCC AATTTTACAT TTAAGGAAGG TGAAATTGTT
GAAGTGGATG AAGAAACAGC AGCTATCTTG AAGAATTCAA GATTTGCTCA AGATTTTCTG
ATCAGACCAA TTGGAGAGAA GTTGCCAACA TCTGGAGGCT GTTCTGCTTT GGAGTTAAAG
GATATAATCA CAGATCCATT TAAGCTTGCA GAAGAGTCTG ACAGTATGAA GTCCAGATGT
GTCCCTGATG CTGCTGGAGG CTGCTGTGGC ACAAAGAAAA GCTGCTAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_065733.2 CDS 124..1251 Translation 
Target ORF information:
RefSeq Version NM_020682.4 Organism Homo sapiens(human) Definition Homo sapiens arsenite methyltransferase (AS3MT), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_020682.4
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081ATGGCTGCAC TTCGTGACGC TGAGATACAG AAGGACGTGC AGACCTACTA CGGGCAGGTG
CTGAAGAGAT CGGCAGACCT CCAGACCAAC GGCTGTGTCA CCACAGCCAG GCCGGTCCCC
AAGCACATCC GGGAAGCCTT GCAAAATGTA CACGAAGAAG TAGCCCTAAG ATATTATGGC
TGTGGTCTGG TGATCCCTGA GCATCTAGAA AACTGCTGGA TTTTGGATCT GGGTAGTGGA
AGTGGCAGAG ATTGCTATGT ACTTAGCCAG CTGGTTGGTG AAAAAGGACA CGTGACTGGA
ATAGACATGA CCAAAGGCCA GGTGGAAGTG GCTGAAAAGT ATCTTGACTA TCACATGGAA
AAATATGGCT TCCAGGCATC TAATGTGACT TTTATTCATG GCTACATTGA GAAGTTGGGA
GAGGCTGGAA TCAAGAATGA GAGCCATGAT ATTGTTGTAT CAAACTGTGT TATTAACCTT
GTGCCTGATA AACAACAAGT GCTTCAGGAG GCATATCGGG TGCTGAAGCA TGGTGGGGAG
TTATATTTCA GTGACGTCTA TACGAGCCTT GAACTGCCAG AAGAAATCAG GACACACAAA
GTTTTATGGG GTGAGTGTCT GGGTGGTGCT TTATACTGGA AGGAACTTGC TGTCCTTGCT
CAAAAAATTG GGTTCTGCCC TCCACGTTTG GTCACTGCCA ATCTCATTAC AATTCAAAAC
AAGGAACTGG AAAGAGTTAT CGGTGACTGT CGTTTTGTTT CTGCAACATT TCGCCTCTTC
AAACACTCTA AGACAGGACC AACCAAGAGA TGCCAAGTTA TTTACAATGG AGGAATTACA
GGACATGAAA AAGAACTAAT GTTTGATGCC AATTTTACAT TTAAGGAAGG TGAAATTGTT
GAAGTGGATG AAGAAACAGC AGCTATCTTG AAGAATTCAA GATTTGCTCA AGATTTTCTG
ATCAGACCAA TTGGAGAGAA GTTGCCAACA TCTGGAGGCT GTTCTGCTTT GGAGTTAAAG
GATATAATCA CAGATCCATT TAAGCTTGCA GAAGAGTCTG ACAGTATGAA GTCCAGATGT
GTCCCTGATG CTGCTGGAGG CTGCTGTGGC ACAAAGAAAA GCTGCTAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OHu24551 Clone ID Related Accession (Same CDS sequence) NM_020682.4 , NM_020682.3 Accession Version NM_020682.3 Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 1128bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1514304000000 Organism Homo sapiens(human) Product arsenite methyltransferase Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA368970.1, BC119638.2, AL358790.22 and AW139845.1. On Jun 21, 2006 this sequence version replaced NM_020682.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.53989.1, SRR1660805.138691.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081ATGGCTGCAC TTCGTGACGC TGAGATACAG AAGGACGTGC AGACCTACTA CGGGCAGGTG
CTGAAGAGAT CGGCAGACCT CCAGACCAAC GGCTGTGTCA CCACAGCCAG GCCGGTCCCC
AAGCACATCC GGGAAGCCTT GCAAAATGTA CACGAAGAAG TAGCCCTAAG ATATTATGGC
TGTGGTCTGG TGATCCCTGA GCATCTAGAA AACTGCTGGA TTTTGGATCT GGGTAGTGGA
AGTGGCAGAG ATTGCTATGT ACTTAGCCAG CTGGTTGGTG AAAAAGGACA CGTGACTGGA
ATAGACATGA CCAAAGGCCA GGTGGAAGTG GCTGAAAAGT ATCTTGACTA TCACATGGAA
AAATATGGCT TCCAGGCATC TAATGTGACT TTTATTCATG GCTACATTGA GAAGTTGGGA
GAGGCTGGAA TCAAGAATGA GAGCCATGAT ATTGTTGTAT CAAACTGTGT TATTAACCTT
GTGCCTGATA AACAACAAGT GCTTCAGGAG GCATATCGGG TGCTGAAGCA TGGTGGGGAG
TTATATTTCA GTGACGTCTA TACGAGCCTT GAACTGCCAG AAGAAATCAG GACACACAAA
GTTTTATGGG GTGAGTGTCT GGGTGGTGCT TTATACTGGA AGGAACTTGC TGTCCTTGCT
CAAAAAATTG GGTTCTGCCC TCCACGTTTG GTCACTGCCA ATCTCATTAC AATTCAAAAC
AAGGAACTGG AAAGAGTTAT CGGTGACTGT CGTTTTGTTT CTGCAACATT TCGCCTCTTC
AAACACTCTA AGACAGGACC AACCAAGAGA TGCCAAGTTA TTTACAATGG AGGAATTACA
GGACATGAAA AAGAACTAAT GTTTGATGCC AATTTTACAT TTAAGGAAGG TGAAATTGTT
GAAGTGGATG AAGAAACAGC AGCTATCTTG AAGAATTCAA GATTTGCTCA AGATTTTCTG
ATCAGACCAA TTGGAGAGAA GTTGCCAACA TCTGGAGGCT GTTCTGCTTT GGAGTTAAAG
GATATAATCA CAGATCCATT TAAGCTTGCA GAAGAGTCTG ACAGTATGAA GTCCAGATGT
GTCCCTGATG CTGCTGGAGG CTGCTGTGGC ACAAAGAAAA GCTGCTAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_065733.2 CDS 141..1268 Translation
Target ORF information:
RefSeq Version NM_020682.3 Organism Homo sapiens(human) Definition Homo sapiens arsenite methyltransferase (AS3MT), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK NM_020682.3
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081ATGGCTGCAC TTCGTGACGC TGAGATACAG AAGGACGTGC AGACCTACTA CGGGCAGGTG
CTGAAGAGAT CGGCAGACCT CCAGACCAAC GGCTGTGTCA CCACAGCCAG GCCGGTCCCC
AAGCACATCC GGGAAGCCTT GCAAAATGTA CACGAAGAAG TAGCCCTAAG ATATTATGGC
TGTGGTCTGG TGATCCCTGA GCATCTAGAA AACTGCTGGA TTTTGGATCT GGGTAGTGGA
AGTGGCAGAG ATTGCTATGT ACTTAGCCAG CTGGTTGGTG AAAAAGGACA CGTGACTGGA
ATAGACATGA CCAAAGGCCA GGTGGAAGTG GCTGAAAAGT ATCTTGACTA TCACATGGAA
AAATATGGCT TCCAGGCATC TAATGTGACT TTTATTCATG GCTACATTGA GAAGTTGGGA
GAGGCTGGAA TCAAGAATGA GAGCCATGAT ATTGTTGTAT CAAACTGTGT TATTAACCTT
GTGCCTGATA AACAACAAGT GCTTCAGGAG GCATATCGGG TGCTGAAGCA TGGTGGGGAG
TTATATTTCA GTGACGTCTA TACGAGCCTT GAACTGCCAG AAGAAATCAG GACACACAAA
GTTTTATGGG GTGAGTGTCT GGGTGGTGCT TTATACTGGA AGGAACTTGC TGTCCTTGCT
CAAAAAATTG GGTTCTGCCC TCCACGTTTG GTCACTGCCA ATCTCATTAC AATTCAAAAC
AAGGAACTGG AAAGAGTTAT CGGTGACTGT CGTTTTGTTT CTGCAACATT TCGCCTCTTC
AAACACTCTA AGACAGGACC AACCAAGAGA TGCCAAGTTA TTTACAATGG AGGAATTACA
GGACATGAAA AAGAACTAAT GTTTGATGCC AATTTTACAT TTAAGGAAGG TGAAATTGTT
GAAGTGGATG AAGAAACAGC AGCTATCTTG AAGAATTCAA GATTTGCTCA AGATTTTCTG
ATCAGACCAA TTGGAGAGAA GTTGCCAACA TCTGGAGGCT GTTCTGCTTT GGAGTTAAAG
GATATAATCA CAGATCCATT TAAGCTTGCA GAAGAGTCTG ACAGTATGAA GTCCAGATGT
GTCCCTGATG CTGCTGGAGG CTGCTGTGGC ACAAAGAAAA GCTGCTAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
-
PubMed
[Polymorphisms of the Arsenite Methyltransferase (As3MT) gene and urinary efficiency of arsenic metabolism in a population in northern Mexico].
Revista peruana de medicina experimental y salud publica35(1)72-76(2018 Jan-Mar)
García-Alvarado FJ,Neri-Meléndez H,Pérez Armendáriz L,Rivera Guillen M
Common variants on 2p16.1, 6p22.1 and 10q24.32 are associated with schizophrenia in Han Chinese population.
Molecular psychiatry22(7)954-960(2017 07)
Yu H,Yan H,Li J,Li Z,Zhang X,Ma Y,Mei L,Liu C,Cai L,Wang Q,Zhang F,Iwata N,Ikeda M,Wang L,Lu T,,Li M,Xu H,Wu X,Liu B,Yang J,Li K,Lv L,Ma X,Wang C,Li L,Yang F,Jiang T,Shi Y,Li T,Zhang D,Yue W
Associations between arsenic (+3 oxidation state) methyltransferase (AS3MT) and N-6 adenine-specific DNA methyltransferase 1 (N6AMT1) polymorphisms, arsenic metabolism, and cancer risk in a chilean population.
Environmental and molecular mutagenesis58(6)411-422(2017 07)
de la Rosa R,Steinmaus C,Akers NK,Conde L,Ferreccio C,Kalman D,Zhang KR,Skibola CF,Smith AH,Zhang L,Smith MT
Relation of polymorphism of arsenic metabolism genes to arsenic methylation capacity and developmental delay in preschool children in Taiwan.
Toxicology and applied pharmacology32137-47(2017 04)
Hsieh RL,Su CT,Shiue HS,Chen WJ,Huang SR,Lin YC,Lin MI,Mu SC,Chen RJ,Hsueh YM
Interactive Influence of N6AMT1 and As3MT Genetic Variations on Arsenic Metabolism in the Population of Inner Mongolia, China.
Toxicological sciences : an official journal of the Society of Toxicology155(1)124-134(2017 01)
Chen X,Guo X,He P,Nie J,Yan X,Zhu J,Zhang L,Mao G,Wu H,Liu Z,Aga D,Xu P,Smith M,Ren X
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