COMMD8 cDNA ORF clone, Homo sapiens(Human)

Gene
Clones
gRNAs

Summary

Gene Symbol	COMMD8
Entrez Gene ID	54951
Full Name	COMM domain containing 8
General protein information	Preferred Names COMM domain containing 8 Names COMM domain-containing protein 8
Gene Type	protein-coding
Organism	Homo sapiens(Human)
Genome	Chromosome: 4 Map Location: 4p12
Summary	The protein encoded by this gene binds coiled-coil domain-containing protein 22 (CCDC22), and this complex can regulate the turnover of I-kappa-B and the activation of NF-kappa-B. [provided by RefSeq, Jul 2016].
Disorder MIM:	616656

mRNA and Protein(s)

mRNA	Protein	Name
XM_017008330.1	XP_016863819.1	COMM domain-containing protein 8 isoform X1
NM_017845.4	NP_060315.1	COMM domain-containing protein 8 isoform 1
NM_001329668.1	NP_001316597.1	COMM domain-containing protein 8 isoform 2
NM_017845.5	NP_060315.1	COMM domain-containing protein 8 isoform 1
NM_017845.3	NP_060315.1	COMM domain-containing protein 8

Pathways from BioSystems

Homologies

Homo sapiens (human)	COMMD8	NP_060315.1
Rattus norvegicus (Norway rat)	Commd8	NP_001099474.1
Danio rerio (zebrafish)	commd8	NP_001071186.1
Macaca mulatta (Rhesus monkey)	COMMD8	XP_001101515.1
Bos taurus (cattle)	COMMD8	XP_002688283.1
Mus musculus (house mouse)	Commd8	NP_848714.1
Gallus gallus (chicken)	COMMD8	NP_001264750.1
Xenopus tropicalis (tropical clawed frog)	commd8	NP_001016404.1
Pan troglodytes (chimpanzee)	COMMD8	XP_001154216.1
Canis lupus familiaris (dog)	COMMD8	XP_532368.2

Gene Ontology
Bibliography

Related articles in PubMed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.
Hubel P, Urban C, Bergant V, Schneider WM, Knauer B, Stukalov A, Scaturro P, Mann A, Brunotte L, Hoffmann HH, Schoggins JW, Schwemmle M, Mann M, Rice CM, Pichlmair A
Nature immunology20(4)493-502(2019 04)

Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling.
McNally KE, Faulkner R, Steinberg F, Gallon M, Ghai R, Pim D, Langton P, Pearson N, Danson CM, Nägele H, Morris LL, Singla A, Overlee BL, Heesom KJ, Sessions R, Banks L, Collins BM, Berger I, Billadeau DD, Burstein E, Cullen PJ
Nature cell biology19(10)1214-1225(2017 Oct)

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

CCDC22 deficiency in humans blunts activation of proinflammatory NF-κB signaling.
Starokadomskyy P, Gluck N, Li H, Chen B, Wallis M, Maine GN, Mao X, Zaidi IW, Hein MY, McDonald FJ, Lenzner S, Zecha A, Ropers HH, Kuss AW, McGaughran J, Gecz J, Burstein E
The Journal of clinical investigation123(5)2244-56(2013 May)

A directed protein interaction network for investigating intracellular signal transduction.
Vinayagam A, Stelzl U, Foulle R, Plassmann S, Zenkner M, Timm J, Assmus HE, Andrade-Navarro MA, Wanker EE
Science signaling4(189)rs8(2011 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following COMMD8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the COMMD8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu38575	NM_001329668.1 Latest version!	Homo sapiens COMM domain containing 8 (COMMD8), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu95246	XM_017008330.1 Latest version!	Homo sapiens COMM domain containing 8 (COMMD8), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu02586	NM_017845.5 Latest version!	Homo sapiens COMM domain containing 8 (COMMD8), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
View Old Accession Versions >>
OHu02586	NM_017845.4	Homo sapiens COMM domain containing 8 (COMMD8), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
OHu02586	NM_017845.3	Homo sapiens COMM domain containing 8 (COMMD8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

COMMD8 ( NM_001329668.1 ) cDNA ORF clone, Homo sapiens(Human) -> NP_001316597.1 Homo sapiens COMM domain containing 8 (COMMD8), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu38575
Clone ID Related Accession (Same CDS sequence)	NM_001329668.1
Accession Version	NM_001329668.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 546bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1570636800000
Organism	Homo sapiens(human)
Product	COMM domain-containing protein 8 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC107398.4 and BC015145.1. Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.120040.1, SRR1163658.457962.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCCGG AAGAGGGGAC GCCCTTGTGG CGGCTGCAGA AGCTGCCGGC CGAGCTGGGC 
CCGCAGCTTC TTCACAAAAT AATTGATGGC ATTTGTGGTC GAGCTTATCC TGTGTACCAA 
GATTATCACA CTGTTTGGGA ATCAGAAGAA TGGATGCACG TTTTAGAAGA TATTGCCAAA 
TTTTTCAAAG CCATAGTTGG TAAAAACTTA CCTGATGAAG AGATATTTCA GCAGTTGAAT 
CAGTTGAATT CACTTCATCA AGAAACTATC ATGAAATGCG TGAAAAGTAG GAAAGATGAA 
ATCAAACAGG CTCTGTCAAG AGAAATAGTT GCTATTTCCT CTGCACAGCT ACAGGATTTT 
GATTGGCAGC TTGCACTTTC CAGTGACAAG ATTGCTGCAT TACGAATGCC ACTTTTAAGC 
CTGCATCTAG ATGTAAAAGA AAATGGTGAA GTAAAACCTT ATTCTATTGA AATGAGTAGA 
GAGGAGCTGC AGAATCTAAT ACAGTCCTTG GAAGCAGCGA ATAAGGTGGT CCTGCAGTTG 
AAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001316597.1
CDS	80..625
Translation	MEPEEGTPLWRLQKLPAELGPQLLHKIIDGICGRAYPVYQDYHTVWESEEWMHVLEDIAKFFKAIVGKNLPDEEIFQQLNQLNSLHQETIMKCVKSRKDEIKQALSREIVAISSAQLQDFDWQLALSSDKIAALRMPLLSLHLDVKENGEVKPYSIEMSREELQNLIQSLEAANKVVLQLK

Target ORF information:

RefSeq Version	NM_001329668.1
Organism	Homo sapiens(human)
Definition	Homo sapiens COMM domain containing 8 (COMMD8), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001329668.1

ORF Insert Sequence:

ATGGAGCCGG AAGAGGGGAC GCCCTTGTGG CGGCTGCAGA AGCTGCCGGC CGAGCTGGGC 
CCGCAGCTTC TTCACAAAAT AATTGATGGC ATTTGTGGTC GAGCTTATCC TGTGTACCAA 
GATTATCACA CTGTTTGGGA ATCAGAAGAA TGGATGCACG TTTTAGAAGA TATTGCCAAA 
TTTTTCAAAG CCATAGTTGG TAAAAACTTA CCTGATGAAG AGATATTTCA GCAGTTGAAT 
CAGTTGAATT CACTTCATCA AGAAACTATC ATGAAATGCG TGAAAAGTAG GAAAGATGAA 
ATCAAACAGG CTCTGTCAAG AGAAATAGTT GCTATTTCCT CTGCACAGCT ACAGGATTTT 
GATTGGCAGC TTGCACTTTC CAGTGACAAG ATTGCTGCAT TACGAATGCC ACTTTTAAGC 
CTGCATCTAG ATGTAAAAGA AAATGGTGAA GTAAAACCTT ATTCTATTGA AATGAGTAGA 
GAGGAGCTGC AGAATCTAAT ACAGTCCTTG GAAGCAGCGA ATAAGGTGGT CCTGCAGTTG 
AAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

COMMD8 ( XM_017008330.1 ) cDNA ORF clone, Homo sapiens(Human) -> XP_016863819.1 Homo sapiens COMM domain containing 8 (COMMD8), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu95246
Clone ID Related Accession (Same CDS sequence)	XM_017008330.1
Accession Version	XM_017008330.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 570bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	COMM domain-containing protein 8 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGCCGG AAGAGGGGAC GCCCTTGTGG CGGCTGCAGA AGCTGCCGGC CGAGCTGGGC 
CCGCAGCTTC TTCACAAAAT AATTGATGGC ATTTGTGGTC GAGCTTATCC TGTGTACCAA 
GATTATCACA CTGTTTGGGA ATCAGAAGAA TGGATGCACG TTTTAGAAGA TATTGCCAAA 
TTTTTCAAAG CCATAGTTGG TAAAAACTTA CCTGATGAAG AGATATTTCA GCAGTTGAAT 
CAGTTGAATT CACTTCATCA AGAAACTATC ATGAAATGCG TGAAAAGTAG GAAAGATGAA 
ATCAAACAGG CTCTGTCAAG AGAAATAGTT GCTATTTCCT CTGCACAGCT ACAGGATTTT 
GATTGGCAGG TAAAGCTTGC ACTTTCCAGT GACAAGATTG CTGCATTACG AATGCCACTT 
TTAAGCCTGC ATCTAGATGT AAAAGAAAAT GGTGAAGTAA AACCTTATTC TATTGAAATG 
AGTAGAGAGG AGCTGCAGAA TCTAATACAG TCCTTGGAAG CAGCGAATAA GGTATTTGCT 
ATAATTTTGT CATATGATTT GAATGTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016863819.1
CDS	52..621
Translation	MEPEEGTPLWRLQKLPAELGPQLLHKIIDGICGRAYPVYQDYHTVWESEEWMHVLEDIAKFFKAIVGKNLPDEEIFQQLNQLNSLHQETIMKCVKSRKDEIKQALSREIVAISSAQLQDFDWQVKLALSSDKIAALRMPLLSLHLDVKENGEVKPYSIEMSREELQNLIQSLEAANKVFAIILSYDLNV

Target ORF information:

RefSeq Version	XM_017008330.1
Organism	Homo sapiens(human)
Definition	Homo sapiens COMM domain containing 8 (COMMD8), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017008330.1

ORF Insert Sequence:

ATGGAGCCGG AAGAGGGGAC GCCCTTGTGG CGGCTGCAGA AGCTGCCGGC CGAGCTGGGC 
CCGCAGCTTC TTCACAAAAT AATTGATGGC ATTTGTGGTC GAGCTTATCC TGTGTACCAA 
GATTATCACA CTGTTTGGGA ATCAGAAGAA TGGATGCACG TTTTAGAAGA TATTGCCAAA 
TTTTTCAAAG CCATAGTTGG TAAAAACTTA CCTGATGAAG AGATATTTCA GCAGTTGAAT 
CAGTTGAATT CACTTCATCA AGAAACTATC ATGAAATGCG TGAAAAGTAG GAAAGATGAA 
ATCAAACAGG CTCTGTCAAG AGAAATAGTT GCTATTTCCT CTGCACAGCT ACAGGATTTT 
GATTGGCAGG TAAAGCTTGC ACTTTCCAGT GACAAGATTG CTGCATTACG AATGCCACTT 
TTAAGCCTGC ATCTAGATGT AAAAGAAAAT GGTGAAGTAA AACCTTATTC TATTGAAATG 
AGTAGAGAGG AGCTGCAGAA TCTAATACAG TCCTTGGAAG CAGCGAATAA GGTATTTGCT 
ATAATTTTGT CATATGATTT GAATGTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

COMMD8 ( NM_017845.4 ) cDNA ORF clone, Homo sapiens(Human) -> NP_060315.1 Homo sapiens COMM domain containing 8 (COMMD8), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu02586
Clone ID Related Accession (Same CDS sequence)	NM_017845.4 , NM_017845.5 , NM_017845.3
Accession Version	NM_017845.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 552bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1504886400000
Organism	Homo sapiens(human)
Product	COMM domain-containing protein 8 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY051002.1, BC008371.1, BC015145.1 and AC107398.4. On Jul 22, 2016 this sequence version replaced NM_017845.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: SRR1163655.41953.1, SRR1163657.559674.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCCGG AAGAGGGGAC GCCCTTGTGG CGGCTGCAGA AGCTGCCGGC CGAGCTGGGC 
CCGCAGCTTC TTCACAAAAT AATTGATGGC ATTTGTGGTC GAGCTTATCC TGTGTACCAA 
GATTATCACA CTGTTTGGGA ATCAGAAGAA TGGATGCACG TTTTAGAAGA TATTGCCAAA 
TTTTTCAAAG CCATAGTTGG TAAAAACTTA CCTGATGAAG AGATATTTCA GCAGTTGAAT 
CAGTTGAATT CACTTCATCA AGAAACTATC ATGAAATGCG TGAAAAGTAG GAAAGATGAA 
ATCAAACAGG CTCTGTCAAG AGAAATAGTT GCTATTTCCT CTGCACAGCT ACAGGATTTT 
GATTGGCAGG TAAAGCTTGC ACTTTCCAGT GACAAGATTG CTGCATTACG AATGCCACTT 
TTAAGCCTGC ATCTAGATGT AAAAGAAAAT GGTGAAGTAA AACCTTATTC TATTGAAATG 
AGTAGAGAGG AGCTGCAGAA TCTAATACAG TCCTTGGAAG CAGCGAATAA GGTGGTCCTG 
CAGTTGAAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060315.1
CDS	80..631
Translation	MEPEEGTPLWRLQKLPAELGPQLLHKIIDGICGRAYPVYQDYHTVWESEEWMHVLEDIAKFFKAIVGKNLPDEEIFQQLNQLNSLHQETIMKCVKSRKDEIKQALSREIVAISSAQLQDFDWQVKLALSSDKIAALRMPLLSLHLDVKENGEVKPYSIEMSREELQNLIQSLEAANKVVLQLK

Target ORF information:

RefSeq Version	NM_017845.4
Organism	Homo sapiens(human)
Definition	Homo sapiens COMM domain containing 8 (COMMD8), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017845.4

ORF Insert Sequence:

ATGGAGCCGG AAGAGGGGAC GCCCTTGTGG CGGCTGCAGA AGCTGCCGGC CGAGCTGGGC 
CCGCAGCTTC TTCACAAAAT AATTGATGGC ATTTGTGGTC GAGCTTATCC TGTGTACCAA 
GATTATCACA CTGTTTGGGA ATCAGAAGAA TGGATGCACG TTTTAGAAGA TATTGCCAAA 
TTTTTCAAAG CCATAGTTGG TAAAAACTTA CCTGATGAAG AGATATTTCA GCAGTTGAAT 
CAGTTGAATT CACTTCATCA AGAAACTATC ATGAAATGCG TGAAAAGTAG GAAAGATGAA 
ATCAAACAGG CTCTGTCAAG AGAAATAGTT GCTATTTCCT CTGCACAGCT ACAGGATTTT 
GATTGGCAGG TAAAGCTTGC ACTTTCCAGT GACAAGATTG CTGCATTACG AATGCCACTT 
TTAAGCCTGC ATCTAGATGT AAAAGAAAAT GGTGAAGTAA AACCTTATTC TATTGAAATG 
AGTAGAGAGG AGCTGCAGAA TCTAATACAG TCCTTGGAAG CAGCGAATAA GGTGGTCCTG 
CAGTTGAAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

COMMD8 ( NM_017845.5 ) cDNA ORF clone, Homo sapiens(Human) -> NP_060315.1 Homo sapiens COMM domain containing 8 (COMMD8), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu02586
Clone ID Related Accession (Same CDS sequence)	NM_017845.4 , NM_017845.5 , NM_017845.3
Accession Version	NM_017845.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 552bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1570636800000
Organism	Homo sapiens(human)
Product	COMM domain-containing protein 8 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC107398.4. On Nov 23, 2018 this sequence version replaced NM_017845.4. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: SRR3476690.734432.1, SRR5189667.132089.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000381571.6/ ENSP00000370984.4 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGCCGG AAGAGGGGAC GCCCTTGTGG CGGCTGCAGA AGCTGCCGGC CGAGCTGGGC 
CCGCAGCTTC TTCACAAAAT AATTGATGGC ATTTGTGGTC GAGCTTATCC TGTGTACCAA 
GATTATCACA CTGTTTGGGA ATCAGAAGAA TGGATGCACG TTTTAGAAGA TATTGCCAAA 
TTTTTCAAAG CCATAGTTGG TAAAAACTTA CCTGATGAAG AGATATTTCA GCAGTTGAAT 
CAGTTGAATT CACTTCATCA AGAAACTATC ATGAAATGCG TGAAAAGTAG GAAAGATGAA 
ATCAAACAGG CTCTGTCAAG AGAAATAGTT GCTATTTCCT CTGCACAGCT ACAGGATTTT 
GATTGGCAGG TAAAGCTTGC ACTTTCCAGT GACAAGATTG CTGCATTACG AATGCCACTT 
TTAAGCCTGC ATCTAGATGT AAAAGAAAAT GGTGAAGTAA AACCTTATTC TATTGAAATG 
AGTAGAGAGG AGCTGCAGAA TCTAATACAG TCCTTGGAAG CAGCGAATAA GGTGGTCCTG 
CAGTTGAAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060315.1
CDS	52..603
Translation	MEPEEGTPLWRLQKLPAELGPQLLHKIIDGICGRAYPVYQDYHTVWESEEWMHVLEDIAKFFKAIVGKNLPDEEIFQQLNQLNSLHQETIMKCVKSRKDEIKQALSREIVAISSAQLQDFDWQVKLALSSDKIAALRMPLLSLHLDVKENGEVKPYSIEMSREELQNLIQSLEAANKVVLQLK

Target ORF information:

RefSeq Version	NM_017845.5
Organism	Homo sapiens(human)
Definition	Homo sapiens COMM domain containing 8 (COMMD8), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017845.5

ORF Insert Sequence:

ATGGAGCCGG AAGAGGGGAC GCCCTTGTGG CGGCTGCAGA AGCTGCCGGC CGAGCTGGGC 
CCGCAGCTTC TTCACAAAAT AATTGATGGC ATTTGTGGTC GAGCTTATCC TGTGTACCAA 
GATTATCACA CTGTTTGGGA ATCAGAAGAA TGGATGCACG TTTTAGAAGA TATTGCCAAA 
TTTTTCAAAG CCATAGTTGG TAAAAACTTA CCTGATGAAG AGATATTTCA GCAGTTGAAT 
CAGTTGAATT CACTTCATCA AGAAACTATC ATGAAATGCG TGAAAAGTAG GAAAGATGAA 
ATCAAACAGG CTCTGTCAAG AGAAATAGTT GCTATTTCCT CTGCACAGCT ACAGGATTTT 
GATTGGCAGG TAAAGCTTGC ACTTTCCAGT GACAAGATTG CTGCATTACG AATGCCACTT 
TTAAGCCTGC ATCTAGATGT AAAAGAAAAT GGTGAAGTAA AACCTTATTC TATTGAAATG 
AGTAGAGAGG AGCTGCAGAA TCTAATACAG TCCTTGGAAG CAGCGAATAA GGTGGTCCTG 
CAGTTGAAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

COMMD8 ( NM_017845.3 ) cDNA ORF clone, Homo sapiens(Human) -> NP_060315.1 Homo sapiens COMM domain containing 8 (COMMD8), mRNA.

Price & Availability↑

CloneID	OHu02586
Clone ID Related Accession (Same CDS sequence)	NM_017845.4 , NM_017845.5 , NM_017845.3
Accession Version	NM_017845.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 552bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1426262400000
Organism	Homo sapiens(Human)
Product	COMM domain-containing protein 8
Comment

ATGGAGCCGG AAGAGGGGAC GCCCTTGTGG CGGCTGCAGA AGCTGCCGGC CGAGCTGGGC 
CCGCAGCTTC TTCACAAAAT AATTGATGGC ATTTGTGGTC GAGCTTATCC TGTGTACCAA 
GATTATCACA CTGTTTGGGA ATCAGAAGAA TGGATGCACG TTTTAGAAGA TATTGCCAAA 
TTTTTCAAAG CCATAGTTGG TAAAAACTTA CCTGATGAAG AGATATTTCA GCAGTTGAAT 
CAGTTGAATT CACTTCATCA AGAAACTATC ATGAAATGCG TGAAAAGTAG GAAAGATGAA 
ATCAAACAGG CTCTGTCAAG AGAAATAGTT GCTATTTCCT CTGCACAGCT ACAGGATTTT 
GATTGGCAGG TAAAGCTTGC ACTTTCCAGT GACAAGATTG CTGCATTACG AATGCCACTT 
TTAAGCCTGC ATCTAGATGT AAAAGAAAAT GGTGAAGTAA AACCTTATTC TATTGAAATG 
AGTAGAGAGG AGCTGCAGAA TCTAATACAG TCCTTGGAAG CAGCGAATAA GGTGGTCCTG 
CAGTTGAAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060315.1
Translation	MEPEEGTPLWRLQKLPAELGPQLLHKIIDGICGRAYPVYQDYHTVWESEEWMHVLEDIAKFFKAIVGKNLPDEEIFQQLNQLNSLHQETIMKCVKSRKDEIKQALSREIVAISSAQLQDFDWQVKLALSSDKIAALRMPLLSLHLDVKENGEVKPYSIEMSREELQNLIQSLEAANKVVLQLK

Target ORF information:

RefSeq Version	NM_017845.3
Organism	Homo sapiens(Human)
Definition	Homo sapiens COMM domain containing 8 (COMMD8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017845.3

ORF Insert Sequence:

ATGGAGCCGG AAGAGGGGAC GCCCTTGTGG CGGCTGCAGA AGCTGCCGGC CGAGCTGGGC 
CCGCAGCTTC TTCACAAAAT AATTGATGGC ATTTGTGGTC GAGCTTATCC TGTGTACCAA 
GATTATCACA CTGTTTGGGA ATCAGAAGAA TGGATGCACG TTTTAGAAGA TATTGCCAAA 
TTTTTCAAAG CCATAGTTGG TAAAAACTTA CCTGATGAAG AGATATTTCA GCAGTTGAAT 
CAGTTGAATT CACTTCATCA AGAAACTATC ATGAAATGCG TGAAAAGTAG GAAAGATGAA 
ATCAAACAGG CTCTGTCAAG AGAAATAGTT GCTATTTCCT CTGCACAGCT ACAGGATTTT 
GATTGGCAGG TAAAGCTTGC ACTTTCCAGT GACAAGATTG CTGCATTACG AATGCCACTT 
TTAAGCCTGC ATCTAGATGT AAAAGAAAAT GGTGAAGTAA AACCTTATTC TATTGAAATG 
AGTAGAGAGG AGCTGCAGAA TCTAATACAG TCCTTGGAAG CAGCGAATAA GGTGGTCCTG 
CAGTTGAAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.
Nature immunology20(4)493-502(2019 04)
Hubel P,Urban C,Bergant V,Schneider WM,Knauer B,Stukalov A,Scaturro P,Mann A,Brunotte L,Hoffmann HH,Schoggins JW,Schwemmle M,Mann M,Rice CM,Pichlmair A

Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling.
Nature cell biology19(10)1214-1225(2017 Oct)
McNally KE,Faulkner R,Steinberg F,Gallon M,Ghai R,Pim D,Langton P,Pearson N,Danson CM,Nägele H,Morris LL,Singla A,Overlee BL,Heesom KJ,Sessions R,Banks L,Collins BM,Berger I,Billadeau DD,Burstein E,Cullen PJ

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

CCDC22 deficiency in humans blunts activation of proinflammatory NF-κB signaling.
The Journal of clinical investigation123(5)2244-56(2013 May)
Starokadomskyy P,Gluck N,Li H,Chen B,Wallis M,Maine GN,Mao X,Zaidi IW,Hein MY,McDonald FJ,Lenzner S,Zecha A,Ropers HH,Kuss AW,McGaughran J,Gecz J,Burstein E

A directed protein interaction network for investigating intracellular signal transduction.
Science signaling4(189)rs8(2011 Sep)
Vinayagam A,Stelzl U,Foulle R,Plassmann S,Zenkner M,Timm J,Assmus HE,Andrade-Navarro MA,Wanker EE

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COMMD8 cDNA ORF clone, Homo sapiens(Human)

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ORF Insert Sequence:

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