| Gene Symbol | PPIC |
| Entrez Gene ID | 5480 |
| Full Name | peptidylprolyl isomerase C |
| Synonyms | CYPC |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase)) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. Similar to other PPIases, this protein can bind immunosuppressant cyclosporin A. [provided by RefSeq, Jul 2008]. |
| Disorder MIM: |
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PPIC cDNA ORF clone, Homo sapiens(human)
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Gene
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Clones
gRNAs
The following PPIC gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PPIC cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OHu02712 Clone ID Related Accession (Same CDS sequence) NM_000943.4 , NM_000943.5 Accession Version NM_000943.4 Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 639bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1529596800000 Organism Homo sapiens(human) Product peptidyl-prolyl cis-trans isomerase C precursor Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG721394.1, CB963241.1, BU075157.1 and BX472017.1. On Mar 15, 2004 this sequence version replaced NM_000943.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279869.1702.1, SRR1660807.257740.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2153307 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.
1
61
121
181
241
301
361
421
481
541
601ATGGGCCCGG GTCCTCGGCT GCTGCTACCT CTCGTGCTTT GCGTGGGGCT CGGCGCACTT
GTGTTTTCTT CGGGGGCCGA GGGCTTCCGC AAGCGAGGCC CCTCGGTGAC GGCCAAGGTC
TTCTTTGATG TGAGGATTGG AGACAAAGAT GTTGGCAGAA TTGTGATTGG CCTCTTTGGA
AAAGTTGTGC CCAAGACAGT GGAAAATTTT GTTGCTCTAG CAACAGGAGA GAAAGGATAT
GGATATAAAG GAAGCAAGTT TCATCGTGTC ATCAAGGATT TCATGATTCA AGGAGGTGAC
ATCACCACTG GAGATGGCAC TGGGGGTGTG AGCATCTATG GTGAGACATT TCCAGATGAG
AACTTCAAGC TGAAGCACTA TGGCATTGGG TGGGTCAGCA TGGCCAACGC TGGGCCTGAC
ACCAATGGCT CTCAGTTCTT TATCACCTTG ACCAAGCCCA CCTGGTTGGA CGGCAAACAT
GTGGTGTTTG GAAAAGTCAT TGATGGGATG ACAGTGGTGC ACTCCATAGA GCTCCAAGCA
ACTGATGGGC ATGACCGTCC ACTCACCAAC TGCTCGATCA TCAACAGTGG CAAGATAGAC
GTGAAAACGC CTTTTGTGGT TGAGATCGCT GATTGGTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_000934.1 CDS 106..744 Translation 
Target ORF information:
RefSeq Version NM_000943.4 Organism Homo sapiens(human) Definition Homo sapiens peptidylprolyl isomerase C (PPIC), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_000943.4
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601ATGGGCCCGG GTCCTCGGCT GCTGCTACCT CTCGTGCTTT GCGTGGGGCT CGGCGCACTT
GTGTTTTCTT CGGGGGCCGA GGGCTTCCGC AAGCGAGGCC CCTCGGTGAC GGCCAAGGTC
TTCTTTGATG TGAGGATTGG AGACAAAGAT GTTGGCAGAA TTGTGATTGG CCTCTTTGGA
AAAGTTGTGC CCAAGACAGT GGAAAATTTT GTTGCTCTAG CAACAGGAGA GAAAGGATAT
GGATATAAAG GAAGCAAGTT TCATCGTGTC ATCAAGGATT TCATGATTCA AGGAGGTGAC
ATCACCACTG GAGATGGCAC TGGGGGTGTG AGCATCTATG GTGAGACATT TCCAGATGAG
AACTTCAAGC TGAAGCACTA TGGCATTGGG TGGGTCAGCA TGGCCAACGC TGGGCCTGAC
ACCAATGGCT CTCAGTTCTT TATCACCTTG ACCAAGCCCA CCTGGTTGGA CGGCAAACAT
GTGGTGTTTG GAAAAGTCAT TGATGGGATG ACAGTGGTGC ACTCCATAGA GCTCCAAGCA
ACTGATGGGC ATGACCGTCC ACTCACCAAC TGCTCGATCA TCAACAGTGG CAAGATAGAC
GTGAAAACGC CTTTTGTGGT TGAGATCGCT GATTGGTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OHu02712 Clone ID Related Accession (Same CDS sequence) NM_000943.4 , NM_000943.5 Accession Version NM_000943.5 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 639bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1571500800000 Organism Homo sapiens(human) Product peptidyl-prolyl cis-trans isomerase C precursor Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB963241.1, BG721394.1, BU075157.1, BX472017.1 and AC022116.5. On May 17, 2019 this sequence version replaced NM_000943.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK290321.1, SRR5189655.21337.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2153307 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000306442.5/ ENSP00000303057.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.
1
61
121
181
241
301
361
421
481
541
601ATGGGCCCGG GTCCTCGGCT GCTGCTACCT CTCGTGCTTT GCGTGGGGCT CGGCGCACTT
GTGTTTTCTT CGGGGGCCGA GGGCTTCCGC AAGCGAGGCC CCTCGGTGAC GGCCAAGGTC
TTCTTTGATG TGAGGATTGG AGACAAAGAT GTTGGCAGAA TTGTGATTGG CCTCTTTGGA
AAAGTTGTGC CCAAGACAGT GGAAAATTTT GTTGCTCTAG CAACAGGAGA GAAAGGATAT
GGATATAAAG GAAGCAAGTT TCATCGTGTC ATCAAGGATT TCATGATTCA AGGAGGTGAC
ATCACCACTG GAGATGGCAC TGGGGGTGTG AGCATCTATG GTGAGACATT TCCAGATGAG
AACTTCAAGC TGAAGCACTA TGGCATTGGG TGGGTCAGCA TGGCCAACGC TGGGCCTGAC
ACCAATGGCT CTCAGTTCTT TATCACCTTG ACCAAGCCCA CCTGGTTGGA CGGCAAACAT
GTGGTGTTTG GAAAAGTCAT TGATGGGATG ACAGTGGTGC ACTCCATAGA GCTCCAAGCA
ACTGATGGGC ATGACCGTCC ACTCACCAAC TGCTCGATCA TCAACAGTGG CAAGATAGAC
GTGAAAACGC CTTTTGTGGT TGAGATCGCT GATTGGTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_000934.1 CDS 101..739 Translation
Target ORF information:
RefSeq Version NM_000943.5 Organism Homo sapiens(human) Definition Homo sapiens peptidylprolyl isomerase C (PPIC), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK NM_000943.5
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601ATGGGCCCGG GTCCTCGGCT GCTGCTACCT CTCGTGCTTT GCGTGGGGCT CGGCGCACTT
GTGTTTTCTT CGGGGGCCGA GGGCTTCCGC AAGCGAGGCC CCTCGGTGAC GGCCAAGGTC
TTCTTTGATG TGAGGATTGG AGACAAAGAT GTTGGCAGAA TTGTGATTGG CCTCTTTGGA
AAAGTTGTGC CCAAGACAGT GGAAAATTTT GTTGCTCTAG CAACAGGAGA GAAAGGATAT
GGATATAAAG GAAGCAAGTT TCATCGTGTC ATCAAGGATT TCATGATTCA AGGAGGTGAC
ATCACCACTG GAGATGGCAC TGGGGGTGTG AGCATCTATG GTGAGACATT TCCAGATGAG
AACTTCAAGC TGAAGCACTA TGGCATTGGG TGGGTCAGCA TGGCCAACGC TGGGCCTGAC
ACCAATGGCT CTCAGTTCTT TATCACCTTG ACCAAGCCCA CCTGGTTGGA CGGCAAACAT
GTGGTGTTTG GAAAAGTCAT TGATGGGATG ACAGTGGTGC ACTCCATAGA GCTCCAAGCA
ACTGATGGGC ATGACCGTCC ACTCACCAAC TGCTCGATCA TCAACAGTGG CAAGATAGAC
GTGAAAACGC CTTTTGTGGT TGAGATCGCT GATTGGTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
PPIC, EMP3 and CHI3L1 Are Novel Prognostic Markers for High Grade Glioma.
International journal of molecular sciences17(11)(2016 Oct)
Gao YF,Zhu T,Mao CX,Liu ZX,Wang ZB,Mao XY,Li L,Yin JY,Zhou HH,Liu ZQ
Cyclophilin C Participates in the US2-Mediated Degradation of Major Histocompatibility Complex Class I Molecules.
PloS one10(12)e0145458(2015)
Chapman DC,Stocki P,Williams DB
Depletion of cyclophilins B and C leads to dysregulation of endoplasmic reticulum redox homeostasis.
The Journal of biological chemistry289(33)23086-96(2014 Aug)
Stocki P,Chapman DC,Beach LA,Williams DB
Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases.
PLoS biology8(7)e1000439(2010 Jul)
Davis TL,Walker JR,Campagna-Slater V,Finerty PJ,Paramanathan R,Bernstein G,MacKenzie F,Tempel W,Ouyang H,Lee WH,Eisenmesser EZ,Dhe-Paganon S
Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data.
JAMA302(2)168-78(2009 Jul)
Vasan RS,Glazer NL,Felix JF,Lieb W,Wild PS,Felix SB,Watzinger N,Larson MG,Smith NL,Dehghan A,Grosshennig A,Schillert A,Teumer A,Schmidt R,Kathiresan S,Lumley T,Aulchenko YS,König IR,Zeller T,Homuth G,Struchalin M,Aragam J,Bis JC,Rivadeneira F,Erdmann J,Schnabel RB,Dörr M,Zweiker R,Lind L,Rodeheffer RJ,Greiser KH,Levy D,Haritunians T,Deckers JW,Stritzke J,Lackner KJ,Völker U,Ingelsson E,Kullo I,Haerting J,O'Donnell CJ,Heckbert SR,Stricker BH,Ziegler A,Reffelmann T,Redfield MM,Werdan K,Mitchell GF,Rice K,Arnett DK,Hofman A,Gottdiener JS,Uitterlinden AG,Meitinger T,Blettner M,Friedrich N,Wang TJ,Psaty BM,van Duijn CM,Wichmann HE,Munzel TF,Kroemer HK,Benjamin EJ,Rotter JI,Witteman JC,Schunkert H,Schmidt H,Völzke H,Blankenberg S
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