ACKR4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ACKR4
Entrez Gene ID	51554
Full Name	atypical chemokine receptor 4
Synonyms	CC-CKR-11,CCBP2,CCR-11,CCR10,CCR11,CCRL1,CCX CKR,CCX-CKR,CKR-11,PPR1,VSHK1
General protein information	Preferred Names atypical chemokine receptor 4 Names atypical chemokine receptor 4 C-C CKR-11 C-C chemokine receptor type 11 CC chemokine receptor-like 1 chemocentryx chemokine receptor chemokine (C-C motif) receptor-like 1 chemokine, cc motif, receptor-like protein 1 orphan seven-transmembrane receptor, chemokine related
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3q22.1
Summary	The protein encoded by this gene is a member of the G protein-coupled receptor family, and is a receptor for C-C type chemokines. This receptor has been shown to bind dendritic cell- and T cell-activated chemokines including CCL19/ELC, CCL21/SLC, and CCL25/TECK. A pseudogene of this gene is found on chromosome 6. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2013].
Disorder MIM:	606065

mRNA and Protein(s)

mRNA	Protein	Name
NM_016557.4	NP_057641.1	atypical chemokine receptor 4
NM_178445.2	NP_848540.1	atypical chemokine receptor 4
NM_016557.3	NP_057641.1	atypical chemokine receptor 4

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CCRL1	XP_001150177.1
Bos taurus (cattle)	ACKR4	NP_776690.1
Mus musculus (house mouse)	Ackr4	NP_663746.2
Homo sapiens (human)	ACKR4	NP_057641.1
Rattus norvegicus (Norway rat)	Ackr4	XP_003750626.1
Danio rerio (zebrafish)	ackr4b	XP_005162666.1
Canis lupus familiaris (dog)	ACKR4	XP_005634482.1
Xenopus tropicalis (tropical clawed frog)	ccrl1	XP_002937785.1
Macaca mulatta (Rhesus monkey)	CCRL1	XP_001115475.1
Danio rerio (zebrafish)	si:ch211-106h4.12	XP_005163521.1
Gallus gallus (chicken)	CCRL1	XP_003640769.2

Gene Ontology
Bibliography

Related articles in PubMed

Fluorescently Tagged CCL19 and CCL21 to Monitor CCR7 and ACKR4 Functions.
Purvanov V, Matti C, Samson GPB, Kindinger I, Legler DF
International journal of molecular sciences19(12)(2018 Dec)

Endogenous expression of the atypical chemokine receptor CCX-CKR (CCRL1) gene in human embryonic kidney (HEK 293) cells.
Salimi P, Esmaeili A, Hashemi M, Behjati M
Molecular and cellular biochemistry412(1-2)229-33(2016 Jan)

Genome-wide association study of CSF levels of 59 alzheimer's disease candidate proteins: significant associations with proteins involved in amyloid processing and inflammation.
Kauwe JS, Bailey MH, Ridge PG, Perry R, Wadsworth ME, Hoyt KL, Staley LA, Karch CM, Harari O, Cruchaga C, Ainscough BJ, Bales K, Pickering EH, Bertelsen S, , Fagan AM, Holtzman DM, Morris JC, Goate AM
PLoS genetics10(10)e1004758(2014 Oct)

Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.
Goldstein JI, Jarskog LF, Hilliard C, Alfirevic A, Duncan L, Fourches D, Huang H, Lek M, Neale BM, Ripke S, Shianna K, Szatkiewicz JP, Tropsha A, van den Oord EJ, Cascorbi I, Dettling M, Gazit E, Goff DC, Holden AL, Kelly DL, Malhotra AK, Nielsen J, Pirmohamed M, Rujescu D, Werge T, Levy DL, Josiassen RC, Kennedy JL, Lieberman JA, Daly MJ, Sullivan PF
Nature communications54757(2014 Sep)

CCX-CKR expression in colorectal cancer and patient survival.
Zhu Y, Tang W, Liu Y, Wang G, Liang Z, Cui L
The International journal of biological markers29(1)e40-8(2014 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following ACKR4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ACKR4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu15458	NM_178445.2 Latest version!	Homo sapiens atypical chemokine receptor 4 (ACKR4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$223.30 $319.00
OHu15458	NM_016557.4 Latest version!	Homo sapiens atypical chemokine receptor 4 (ACKR4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$223.30 $319.00
View Old Accession Versions >>
OHu15458	NM_016557.3	Homo sapiens atypical chemokine receptor 4 (ACKR4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$223.30 $319.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ACKR4 ( NM_016557.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_057641.1 Homo sapiens atypical chemokine receptor 4 (ACKR4), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu15458
Clone ID Related Accession (Same CDS sequence)	NM_016557.4 , NM_178445.2 , NM_016557.3
Accession Version	NM_016557.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1053bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1571846400000
Organism	Homo sapiens(human)
Product	atypical chemokine receptor 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC419249.1, AF110640.1, AK225927.1 and BQ015927.1. On May 17, 2019 this sequence version replaced NM_016557.3. Transcript Variant: This variant (2) differs in the 5' UTR, as compared to variant 1. Both variants encode the some protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK313923.1, AF110640.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000249887.3/ ENSP00000249887.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END##

ATGGCTTTGG AACAGAACCA GTCAACAGAT TATTATTATG AGGAAAATGA AATGAATGGC 
ACTTATGACT ACAGTCAATA TGAACTGATC TGTATCAAAG AAGATGTCAG AGAATTTGCA 
AAAGTTTTCC TCCCTGTATT CCTCACAATA GTTTTCGTCA TTGGACTTGC AGGCAATTCC 
ATGGTAGTGG CAATTTATGC CTATTACAAG AAACAGAGAA CCAAAACAGA TGTGTACATC 
CTGAATTTGG CTGTAGCAGA TTTACTCCTT CTATTCACTC TGCCTTTTTG GGCTGTTAAT 
GCAGTTCATG GGTGGGTTTT AGGGAAAATA ATGTGCAAAA TAACTTCAGC CTTGTACACA 
CTAAACTTTG TCTCTGGAAT GCAGTTTCTG GCTTGTATCA GCATAGACAG ATATGTGGCA 
GTAACTAAAG TCCCCAGCCA ATCAGGAGTG GGAAAACCAT GCTGGATCAT CTGTTTCTGT 
GTCTGGATGG CTGCCATCTT GCTGAGCATA CCCCAGCTGG TTTTTTATAC AGTAAATGAC 
AATGCTAGGT GCATTCCCAT TTTCCCCCGC TACCTAGGAA CATCAATGAA AGCATTGATT 
CAAATGCTAG AGATCTGCAT TGGATTTGTA GTACCCTTTC TTATTATGGG GGTGTGCTAC 
TTTATCACAG CAAGGACACT CATGAAGATG CCAAACATTA AAATATCTCG ACCCCTAAAA 
GTTCTGCTCA CAGTCGTTAT AGTTTTCATT GTCACTCAAC TGCCTTATAA CATTGTCAAG 
TTCTGCCGAG CCATAGACAT CATCTACTCC CTGATCACCA GCTGCAACAT GAGCAAACGC 
ATGGACATCG CCATCCAAGT CACAGAAAGC ATCGCACTCT TTCACAGCTG CCTCAACCCA 
ATCCTTTATG TTTTTATGGG AGCATCTTTC AAAAACTACG TTATGAAAGT GGCCAAGAAA 
TATGGGTCCT GGAGAAGACA GAGACAAAGT GTGGAGGAGT TTCCTTTTGA TTCTGAGGGT 
CCTACAGAGC CAACCAGTAC TTTTAGCATT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057641.1
CDS	64..1116
Translation	MALEQNQSTDYYYEENEMNGTYDYSQYELICIKEDVREFAKVFLPVFLTIVFVIGLAGNSMVVAIYAYYKKQRTKTDVYILNLAVADLLLLFTLPFWAVNAVHGWVLGKIMCKITSALYTLNFVSGMQFLACISIDRYVAVTKVPSQSGVGKPCWIICFCVWMAAILLSIPQLVFYTVNDNARCIPIFPRYLGTSMKALIQMLEICIGFVVPFLIMGVCYFITARTLMKMPNIKISRPLKVLLTVVIVFIVTQLPYNIVKFCRAIDIIYSLITSCNMSKRMDIAIQVTESIALFHSCLNPILYVFMGASFKNYVMKVAKKYGSWRRQRQSVEEFPFDSEGPTEPTSTFSI

Target ORF information:

RefSeq Version	NM_016557.4
Organism	Homo sapiens(human)
Definition	Homo sapiens atypical chemokine receptor 4 (ACKR4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016557.4

ORF Insert Sequence:

ATGGCTTTGG AACAGAACCA GTCAACAGAT TATTATTATG AGGAAAATGA AATGAATGGC 
ACTTATGACT ACAGTCAATA TGAACTGATC TGTATCAAAG AAGATGTCAG AGAATTTGCA 
AAAGTTTTCC TCCCTGTATT CCTCACAATA GTTTTCGTCA TTGGACTTGC AGGCAATTCC 
ATGGTAGTGG CAATTTATGC CTATTACAAG AAACAGAGAA CCAAAACAGA TGTGTACATC 
CTGAATTTGG CTGTAGCAGA TTTACTCCTT CTATTCACTC TGCCTTTTTG GGCTGTTAAT 
GCAGTTCATG GGTGGGTTTT AGGGAAAATA ATGTGCAAAA TAACTTCAGC CTTGTACACA 
CTAAACTTTG TCTCTGGAAT GCAGTTTCTG GCTTGTATCA GCATAGACAG ATATGTGGCA 
GTAACTAAAG TCCCCAGCCA ATCAGGAGTG GGAAAACCAT GCTGGATCAT CTGTTTCTGT 
GTCTGGATGG CTGCCATCTT GCTGAGCATA CCCCAGCTGG TTTTTTATAC AGTAAATGAC 
AATGCTAGGT GCATTCCCAT TTTCCCCCGC TACCTAGGAA CATCAATGAA AGCATTGATT 
CAAATGCTAG AGATCTGCAT TGGATTTGTA GTACCCTTTC TTATTATGGG GGTGTGCTAC 
TTTATCACAG CAAGGACACT CATGAAGATG CCAAACATTA AAATATCTCG ACCCCTAAAA 
GTTCTGCTCA CAGTCGTTAT AGTTTTCATT GTCACTCAAC TGCCTTATAA CATTGTCAAG 
TTCTGCCGAG CCATAGACAT CATCTACTCC CTGATCACCA GCTGCAACAT GAGCAAACGC 
ATGGACATCG CCATCCAAGT CACAGAAAGC ATCGCACTCT TTCACAGCTG CCTCAACCCA 
ATCCTTTATG TTTTTATGGG AGCATCTTTC AAAAACTACG TTATGAAAGT GGCCAAGAAA 
TATGGGTCCT GGAGAAGACA GAGACAAAGT GTGGAGGAGT TTCCTTTTGA TTCTGAGGGT 
CCTACAGAGC CAACCAGTAC TTTTAGCATT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ACKR4 ( NM_178445.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_848540.1 Homo sapiens atypical chemokine receptor 4 (ACKR4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu15458
Clone ID Related Accession (Same CDS sequence)	NM_016557.4 , NM_178445.2 , NM_016557.3
Accession Version	NM_178445.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1053bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1564848000000
Organism	Homo sapiens(human)
Product	atypical chemokine receptor 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC020632.16. On Jul 2, 2013 this sequence version replaced NM_178445.1. Transcript Variant: This variant (1) differs in the 5' UTR, as compared to variant 2. Both variants encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

ATGGCTTTGG AACAGAACCA GTCAACAGAT TATTATTATG AGGAAAATGA AATGAATGGC 
ACTTATGACT ACAGTCAATA TGAACTGATC TGTATCAAAG AAGATGTCAG AGAATTTGCA 
AAAGTTTTCC TCCCTGTATT CCTCACAATA GTTTTCGTCA TTGGACTTGC AGGCAATTCC 
ATGGTAGTGG CAATTTATGC CTATTACAAG AAACAGAGAA CCAAAACAGA TGTGTACATC 
CTGAATTTGG CTGTAGCAGA TTTACTCCTT CTATTCACTC TGCCTTTTTG GGCTGTTAAT 
GCAGTTCATG GGTGGGTTTT AGGGAAAATA ATGTGCAAAA TAACTTCAGC CTTGTACACA 
CTAAACTTTG TCTCTGGAAT GCAGTTTCTG GCTTGTATCA GCATAGACAG ATATGTGGCA 
GTAACTAAAG TCCCCAGCCA ATCAGGAGTG GGAAAACCAT GCTGGATCAT CTGTTTCTGT 
GTCTGGATGG CTGCCATCTT GCTGAGCATA CCCCAGCTGG TTTTTTATAC AGTAAATGAC 
AATGCTAGGT GCATTCCCAT TTTCCCCCGC TACCTAGGAA CATCAATGAA AGCATTGATT 
CAAATGCTAG AGATCTGCAT TGGATTTGTA GTACCCTTTC TTATTATGGG GGTGTGCTAC 
TTTATCACAG CAAGGACACT CATGAAGATG CCAAACATTA AAATATCTCG ACCCCTAAAA 
GTTCTGCTCA CAGTCGTTAT AGTTTTCATT GTCACTCAAC TGCCTTATAA CATTGTCAAG 
TTCTGCCGAG CCATAGACAT CATCTACTCC CTGATCACCA GCTGCAACAT GAGCAAACGC 
ATGGACATCG CCATCCAAGT CACAGAAAGC ATCGCACTCT TTCACAGCTG CCTCAACCCA 
ATCCTTTATG TTTTTATGGG AGCATCTTTC AAAAACTACG TTATGAAAGT GGCCAAGAAA 
TATGGGTCCT GGAGAAGACA GAGACAAAGT GTGGAGGAGT TTCCTTTTGA TTCTGAGGGT 
CCTACAGAGC CAACCAGTAC TTTTAGCATT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_848540.1
CDS	262..1314
Translation	MALEQNQSTDYYYEENEMNGTYDYSQYELICIKEDVREFAKVFLPVFLTIVFVIGLAGNSMVVAIYAYYKKQRTKTDVYILNLAVADLLLLFTLPFWAVNAVHGWVLGKIMCKITSALYTLNFVSGMQFLACISIDRYVAVTKVPSQSGVGKPCWIICFCVWMAAILLSIPQLVFYTVNDNARCIPIFPRYLGTSMKALIQMLEICIGFVVPFLIMGVCYFITARTLMKMPNIKISRPLKVLLTVVIVFIVTQLPYNIVKFCRAIDIIYSLITSCNMSKRMDIAIQVTESIALFHSCLNPILYVFMGASFKNYVMKVAKKYGSWRRQRQSVEEFPFDSEGPTEPTSTFSI

Target ORF information:

RefSeq Version	NM_178445.2
Organism	Homo sapiens(human)
Definition	Homo sapiens atypical chemokine receptor 4 (ACKR4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_178445.2

ORF Insert Sequence:

ATGGCTTTGG AACAGAACCA GTCAACAGAT TATTATTATG AGGAAAATGA AATGAATGGC 
ACTTATGACT ACAGTCAATA TGAACTGATC TGTATCAAAG AAGATGTCAG AGAATTTGCA 
AAAGTTTTCC TCCCTGTATT CCTCACAATA GTTTTCGTCA TTGGACTTGC AGGCAATTCC 
ATGGTAGTGG CAATTTATGC CTATTACAAG AAACAGAGAA CCAAAACAGA TGTGTACATC 
CTGAATTTGG CTGTAGCAGA TTTACTCCTT CTATTCACTC TGCCTTTTTG GGCTGTTAAT 
GCAGTTCATG GGTGGGTTTT AGGGAAAATA ATGTGCAAAA TAACTTCAGC CTTGTACACA 
CTAAACTTTG TCTCTGGAAT GCAGTTTCTG GCTTGTATCA GCATAGACAG ATATGTGGCA 
GTAACTAAAG TCCCCAGCCA ATCAGGAGTG GGAAAACCAT GCTGGATCAT CTGTTTCTGT 
GTCTGGATGG CTGCCATCTT GCTGAGCATA CCCCAGCTGG TTTTTTATAC AGTAAATGAC 
AATGCTAGGT GCATTCCCAT TTTCCCCCGC TACCTAGGAA CATCAATGAA AGCATTGATT 
CAAATGCTAG AGATCTGCAT TGGATTTGTA GTACCCTTTC TTATTATGGG GGTGTGCTAC 
TTTATCACAG CAAGGACACT CATGAAGATG CCAAACATTA AAATATCTCG ACCCCTAAAA 
GTTCTGCTCA CAGTCGTTAT AGTTTTCATT GTCACTCAAC TGCCTTATAA CATTGTCAAG 
TTCTGCCGAG CCATAGACAT CATCTACTCC CTGATCACCA GCTGCAACAT GAGCAAACGC 
ATGGACATCG CCATCCAAGT CACAGAAAGC ATCGCACTCT TTCACAGCTG CCTCAACCCA 
ATCCTTTATG TTTTTATGGG AGCATCTTTC AAAAACTACG TTATGAAAGT GGCCAAGAAA 
TATGGGTCCT GGAGAAGACA GAGACAAAGT GTGGAGGAGT TTCCTTTTGA TTCTGAGGGT 
CCTACAGAGC CAACCAGTAC TTTTAGCATT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ACKR4 ( NM_016557.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_057641.1 Homo sapiens atypical chemokine receptor 4 (ACKR4), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu15458
Clone ID Related Accession (Same CDS sequence)	NM_016557.4 , NM_178445.2 , NM_016557.3
Accession Version	NM_016557.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1053bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1550851200000
Organism	Homo sapiens(human)
Product	atypical chemokine receptor 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC419249.1, AF110640.1, AK225927.1 and BQ015927.1. On Jul 2, 2013 this sequence version replaced NM_016557.2. Transcript Variant: This variant (2) differs in the 5' UTR, as compared to variant 1. Both variants encode the some protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK304461.1, AF110640.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGGCTTTGG AACAGAACCA GTCAACAGAT TATTATTATG AGGAAAATGA AATGAATGGC 
ACTTATGACT ACAGTCAATA TGAACTGATC TGTATCAAAG AAGATGTCAG AGAATTTGCA 
AAAGTTTTCC TCCCTGTATT CCTCACAATA GTTTTCGTCA TTGGACTTGC AGGCAATTCC 
ATGGTAGTGG CAATTTATGC CTATTACAAG AAACAGAGAA CCAAAACAGA TGTGTACATC 
CTGAATTTGG CTGTAGCAGA TTTACTCCTT CTATTCACTC TGCCTTTTTG GGCTGTTAAT 
GCAGTTCATG GGTGGGTTTT AGGGAAAATA ATGTGCAAAA TAACTTCAGC CTTGTACACA 
CTAAACTTTG TCTCTGGAAT GCAGTTTCTG GCTTGTATCA GCATAGACAG ATATGTGGCA 
GTAACTAAAG TCCCCAGCCA ATCAGGAGTG GGAAAACCAT GCTGGATCAT CTGTTTCTGT 
GTCTGGATGG CTGCCATCTT GCTGAGCATA CCCCAGCTGG TTTTTTATAC AGTAAATGAC 
AATGCTAGGT GCATTCCCAT TTTCCCCCGC TACCTAGGAA CATCAATGAA AGCATTGATT 
CAAATGCTAG AGATCTGCAT TGGATTTGTA GTACCCTTTC TTATTATGGG GGTGTGCTAC 
TTTATCACAG CAAGGACACT CATGAAGATG CCAAACATTA AAATATCTCG ACCCCTAAAA 
GTTCTGCTCA CAGTCGTTAT AGTTTTCATT GTCACTCAAC TGCCTTATAA CATTGTCAAG 
TTCTGCCGAG CCATAGACAT CATCTACTCC CTGATCACCA GCTGCAACAT GAGCAAACGC 
ATGGACATCG CCATCCAAGT CACAGAAAGC ATCGCACTCT TTCACAGCTG CCTCAACCCA 
ATCCTTTATG TTTTTATGGG AGCATCTTTC AAAAACTACG TTATGAAAGT GGCCAAGAAA 
TATGGGTCCT GGAGAAGACA GAGACAAAGT GTGGAGGAGT TTCCTTTTGA TTCTGAGGGT 
CCTACAGAGC CAACCAGTAC TTTTAGCATT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057641.1
CDS	97..1149
Translation	MALEQNQSTDYYYEENEMNGTYDYSQYELICIKEDVREFAKVFLPVFLTIVFVIGLAGNSMVVAIYAYYKKQRTKTDVYILNLAVADLLLLFTLPFWAVNAVHGWVLGKIMCKITSALYTLNFVSGMQFLACISIDRYVAVTKVPSQSGVGKPCWIICFCVWMAAILLSIPQLVFYTVNDNARCIPIFPRYLGTSMKALIQMLEICIGFVVPFLIMGVCYFITARTLMKMPNIKISRPLKVLLTVVIVFIVTQLPYNIVKFCRAIDIIYSLITSCNMSKRMDIAIQVTESIALFHSCLNPILYVFMGASFKNYVMKVAKKYGSWRRQRQSVEEFPFDSEGPTEPTSTFSI

Target ORF information:

RefSeq Version	NM_016557.3
Organism	Homo sapiens(human)
Definition	Homo sapiens atypical chemokine receptor 4 (ACKR4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016557.3

ORF Insert Sequence:

ATGGCTTTGG AACAGAACCA GTCAACAGAT TATTATTATG AGGAAAATGA AATGAATGGC 
ACTTATGACT ACAGTCAATA TGAACTGATC TGTATCAAAG AAGATGTCAG AGAATTTGCA 
AAAGTTTTCC TCCCTGTATT CCTCACAATA GTTTTCGTCA TTGGACTTGC AGGCAATTCC 
ATGGTAGTGG CAATTTATGC CTATTACAAG AAACAGAGAA CCAAAACAGA TGTGTACATC 
CTGAATTTGG CTGTAGCAGA TTTACTCCTT CTATTCACTC TGCCTTTTTG GGCTGTTAAT 
GCAGTTCATG GGTGGGTTTT AGGGAAAATA ATGTGCAAAA TAACTTCAGC CTTGTACACA 
CTAAACTTTG TCTCTGGAAT GCAGTTTCTG GCTTGTATCA GCATAGACAG ATATGTGGCA 
GTAACTAAAG TCCCCAGCCA ATCAGGAGTG GGAAAACCAT GCTGGATCAT CTGTTTCTGT 
GTCTGGATGG CTGCCATCTT GCTGAGCATA CCCCAGCTGG TTTTTTATAC AGTAAATGAC 
AATGCTAGGT GCATTCCCAT TTTCCCCCGC TACCTAGGAA CATCAATGAA AGCATTGATT 
CAAATGCTAG AGATCTGCAT TGGATTTGTA GTACCCTTTC TTATTATGGG GGTGTGCTAC 
TTTATCACAG CAAGGACACT CATGAAGATG CCAAACATTA AAATATCTCG ACCCCTAAAA 
GTTCTGCTCA CAGTCGTTAT AGTTTTCATT GTCACTCAAC TGCCTTATAA CATTGTCAAG 
TTCTGCCGAG CCATAGACAT CATCTACTCC CTGATCACCA GCTGCAACAT GAGCAAACGC 
ATGGACATCG CCATCCAAGT CACAGAAAGC ATCGCACTCT TTCACAGCTG CCTCAACCCA 
ATCCTTTATG TTTTTATGGG AGCATCTTTC AAAAACTACG TTATGAAAGT GGCCAAGAAA 
TATGGGTCCT GGAGAAGACA GAGACAAAGT GTGGAGGAGT TTCCTTTTGA TTCTGAGGGT 
CCTACAGAGC CAACCAGTAC TTTTAGCATT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Fluorescently Tagged CCL19 and CCL21 to Monitor CCR7 and ACKR4 Functions.
International journal of molecular sciences19(12)(2018 Dec)
Purvanov V,Matti C,Samson GPB,Kindinger I,Legler DF

Endogenous expression of the atypical chemokine receptor CCX-CKR (CCRL1) gene in human embryonic kidney (HEK 293) cells.
Molecular and cellular biochemistry412(1-2)229-33(2016 Jan)
Salimi P,Esmaeili A,Hashemi M,Behjati M

Genome-wide association study of CSF levels of 59 alzheimer's disease candidate proteins: significant associations with proteins involved in amyloid processing and inflammation.
PLoS genetics10(10)e1004758(2014 Oct)
Kauwe JS,Bailey MH,Ridge PG,Perry R,Wadsworth ME,Hoyt KL,Staley LA,Karch CM,Harari O,Cruchaga C,Ainscough BJ,Bales K,Pickering EH,Bertelsen S,,Fagan AM,Holtzman DM,Morris JC,Goate AM

Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.
Nature communications54757(2014 Sep)
Goldstein JI,Jarskog LF,Hilliard C,Alfirevic A,Duncan L,Fourches D,Huang H,Lek M,Neale BM,Ripke S,Shianna K,Szatkiewicz JP,Tropsha A,van den Oord EJ,Cascorbi I,Dettling M,Gazit E,Goff DC,Holden AL,Kelly DL,Malhotra AK,Nielsen J,Pirmohamed M,Rujescu D,Werge T,Levy DL,Josiassen RC,Kennedy JL,Lieberman JA,Daly MJ,Sullivan PF

CCX-CKR expression in colorectal cancer and patient survival.
The International journal of biological markers29(1)e40-8(2014 Mar)
Zhu Y,Tang W,Liu Y,Wang G,Liang Z,Cui L

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