GSKIP cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GSKIP
Entrez Gene ID	51527
Full Name	GSK3B interacting protein
Synonyms	C14orf129,HSPC210
General protein information	Preferred Names GSK3B interacting protein Names GSK3B-interacting protein GSK3-beta interaction protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 14 Map Location: 14q32.2
Summary	This gene encodes a protein that is involved as a negative regulator of GSK3-beta in the Wnt signaling pathway. The encoded protein may play a role in the retinoic acid signaling pathway by regulating the functional interactions between GSK3-beta, beta-catenin and cyclin D1, and it regulates the beta-catenin/N-cadherin pool. The encoded protein contains a GSK3-beta interacting domain (GID) in its C-terminus, which is similar to the GID of Axin. The protein also contains an evolutionarily conserved RII-binding domain, which facilitates binding with protein kinase-A and GSK3-beta, enabling its role as an A-kinase anchoring protein. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012].
Disorder MIM:	616605

mRNA and Protein(s)

mRNA	Protein	Name
NM_001271906.1	NP_001258835.1	GSK3B-interacting protein
XM_017021365.1	XP_016876854.1	GSK3B-interacting protein isoform X1
NM_001271905.1	NP_001258834.1	GSK3B-interacting protein
NM_016472.4	NP_057556.2	GSK3B-interacting protein
NM_016472.5	NP_057556.2	GSK3B-interacting protein
NM_001271904.1	NP_001258833.1	GSK3B-interacting protein
XM_024449626.1	XP_024305394.1	GSK3B-interacting protein isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	GSKIP	NP_057556.2
Macaca mulatta (Rhesus monkey)	GSKIP	XP_001101611.1
Rattus norvegicus (Norway rat)	Gskip	NP_001014220.2
Gallus gallus (chicken)	C5H14ORF129	NP_001008473.1
Canis lupus familiaris (dog)	GSKIP	XP_868530.1
Bos taurus (cattle)	GSKIP	NP_001071524.1
Pan troglodytes (chimpanzee)	C14H14orf129	NP_001229499.1
Danio rerio (zebrafish)	gskip	NP_998600.1
Mus musculus (house mouse)	Gskip	NP_848728.2
Xenopus tropicalis (tropical clawed frog)	gskip	NP_001096457.1

Gene Ontology
Bibliography

Related articles in PubMed

The origin of GSKIP, a multifaceted regulatory factor in the mammalian Wnt pathway.
Chou CH, Yang MC, Hsiao BX, Wang YH, Liu HF, Chiou SJ, Chuang YC, Yang CN, Lieu AS, Loh JK, Howng SL, Chou AK, Tseng CN, Cheng JT, Hong YR
Biochimica et biophysica acta. Molecular cell research1865(8)1046-1059(2018 08)

An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations.
Liu X, Salokas K, Tamene F, Jiu Y, Weldatsadik RG, Öhman T, Varjosalo M
Nature communications9(1)1188(2018 03)

The A-Kinase Anchoring Protein (AKAP) Glycogen Synthase Kinase 3β Interaction Protein (GSKIP) Regulates β-Catenin through Its Interactions with Both Protein Kinase A (PKA) and GSK3β.
Dema A, Schröter MF, Perets E, Skroblin P, Moutty MC, Deàk VA, Birchmeier W, Klussmann E
The Journal of biological chemistry291(37)19618-30(2016 09)

Germline duplication of ATG2B and GSKIP predisposes to familial myeloid malignancies.
Saliba J, Saint-Martin C, Di Stefano A, Lenglet G, Marty C, Keren B, Pasquier F, Valle VD, Secardin L, Leroy G, Mahfoudhi E, Grosjean S, Droin N, Diop M, Dessen P, Charrier S, Palazzo A, Merlevede J, Meniane JC, Delaunay-Darivon C, Fuseau P, Isnard F, Casadevall N, Solary E, Debili N, Bernard OA, Raslova H, Najman A, Vainchenker W, Bellanné-Chantelot C, Plo I
Nature genetics47(10)1131-40(2015 Oct)

GSKIP- and GSK3-mediated anchoring strengthens cAMP/PKA/Drp1 axis signaling in the regulation of mitochondrial elongation.
Loh JK, Lin CC, Yang MC, Chou CH, Chen WS, Hong MC, Cho CL, Hsu CM, Cheng JT, Chou AK, Chang CH, Tseng CN, Wang CH, Lieu AS, Howng SL, Hong YR
Biochimica et biophysica acta1853(8)1796-807(2015 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following GSKIP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GSKIP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu01583	NM_001271904.1 Latest version!	Homo sapiens GSK3B interacting protein (GSKIP), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
OHu01583	NM_016472.5 Latest version!	Homo sapiens GSK3B interacting protein (GSKIP), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
OHu01583	NM_001271906.1 Latest version!	Homo sapiens GSK3B interacting protein (GSKIP), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
OHu01583	NM_001271905.1 Latest version!	Homo sapiens GSK3B interacting protein (GSKIP), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
OHu01583	XM_017021365.1 Latest version!	Homo sapiens GSK3B interacting protein (GSKIP), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
OHu01583	XM_024449626.1 Latest version!	Homo sapiens GSK3B interacting protein (GSKIP), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
View Old Accession Versions >>
OHu01583	NM_016472.4	Homo sapiens GSK3B interacting protein (GSKIP), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GSKIP ( NM_001271906.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001258835.1 Homo sapiens GSK3B interacting protein (GSKIP), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu01583
Clone ID Related Accession (Same CDS sequence)	NM_001271906.1 , XM_017021365.1 , NM_001271905.1 , NM_016472.4 , NM_016472.5 , NM_001271904.1 , XM_024449626.1
Accession Version	NM_001271906.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 420bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1545408000000
Organism	Homo sapiens(human)
Product	GSK3B-interacting protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY051680.1, HY108584.1, AK094654.1, AL359240.4 and W04717.1. Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.203984.1, SRR1660809.80665.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA2144335 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAAACAG ACTGTAATCC CATGGAGCTA AGCAGTATGT CAGGATTTGA AGAAGGTTCA 
GAGCTGAACG GTTTTGAAGG AACTGACATG AAAGACATGA GGCTCGAAGC TGAAGCAGTT 
GTAAATGATG TTCTCTTTGC TGTTAACAAC ATGTTTGTCT CGAAAAGCCT GCGGTGTGCG 
GATGATGTGG CCTATATCAA TGTGGAAACA AAGGAAAGAA ACAGATATTG CCTAGAACTC 
ACTGAAGCAG GGCTCAAGGT GGTAGGCTAT GCTTTTGACC AGGTAGATGA TCATTTACAG 
ACTCCCTACC ATGAAACAGT CTACTCCTTG TTGGATACAC TCAGCCCCGC CTACCGAGAA 
GCATTTGGAA ACGCACTGCT TCAAAGACTG GAAGCTTTGA AAAGAGATGG ACAGTCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001258835.1
CDS	119..538
Translation	METDCNPMELSSMSGFEEGSELNGFEGTDMKDMRLEAEAVVNDVLFAVNNMFVSKSLRCADDVAYINVETKERNRYCLELTEAGLKVVGYAFDQVDDHLQTPYHETVYSLLDTLSPAYREAFGNALLQRLEALKRDGQS

Target ORF information:

RefSeq Version	NM_001271906.1
Organism	Homo sapiens(human)
Definition	Homo sapiens GSK3B interacting protein (GSKIP), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001271906.1

ORF Insert Sequence:

ATGGAAACAG ACTGTAATCC CATGGAGCTA AGCAGTATGT CAGGATTTGA AGAAGGTTCA 
GAGCTGAACG GTTTTGAAGG AACTGACATG AAAGACATGA GGCTCGAAGC TGAAGCAGTT 
GTAAATGATG TTCTCTTTGC TGTTAACAAC ATGTTTGTCT CGAAAAGCCT GCGGTGTGCG 
GATGATGTGG CCTATATCAA TGTGGAAACA AAGGAAAGAA ACAGATATTG CCTAGAACTC 
ACTGAAGCAG GGCTCAAGGT GGTAGGCTAT GCTTTTGACC AGGTAGATGA TCATTTACAG 
ACTCCCTACC ATGAAACAGT CTACTCCTTG TTGGATACAC TCAGCCCCGC CTACCGAGAA 
GCATTTGGAA ACGCACTGCT TCAAAGACTG GAAGCTTTGA AAAGAGATGG ACAGTCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GSKIP ( NM_001271905.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001258834.1 Homo sapiens GSK3B interacting protein (GSKIP), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu01583
Clone ID Related Accession (Same CDS sequence)	NM_001271906.1 , XM_017021365.1 , NM_001271905.1 , NM_016472.4 , NM_016472.5 , NM_001271904.1 , XM_024449626.1
Accession Version	NM_001271905.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 420bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1545408000000
Organism	Homo sapiens(human)
Product	GSK3B-interacting protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY051680.1, DA488110.1, AK094654.1, AL359240.4 and W04717.1. Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.303498.1, BG776973.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAAACAG ACTGTAATCC CATGGAGCTA AGCAGTATGT CAGGATTTGA AGAAGGTTCA 
GAGCTGAACG GTTTTGAAGG AACTGACATG AAAGACATGA GGCTCGAAGC TGAAGCAGTT 
GTAAATGATG TTCTCTTTGC TGTTAACAAC ATGTTTGTCT CGAAAAGCCT GCGGTGTGCG 
GATGATGTGG CCTATATCAA TGTGGAAACA AAGGAAAGAA ACAGATATTG CCTAGAACTC 
ACTGAAGCAG GGCTCAAGGT GGTAGGCTAT GCTTTTGACC AGGTAGATGA TCATTTACAG 
ACTCCCTACC ATGAAACAGT CTACTCCTTG TTGGATACAC TCAGCCCCGC CTACCGAGAA 
GCATTTGGAA ACGCACTGCT TCAAAGACTG GAAGCTTTGA AAAGAGATGG ACAGTCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001258834.1
CDS	187..606
Translation	METDCNPMELSSMSGFEEGSELNGFEGTDMKDMRLEAEAVVNDVLFAVNNMFVSKSLRCADDVAYINVETKERNRYCLELTEAGLKVVGYAFDQVDDHLQTPYHETVYSLLDTLSPAYREAFGNALLQRLEALKRDGQS

Target ORF information:

RefSeq Version	NM_001271905.1
Organism	Homo sapiens(human)
Definition	Homo sapiens GSK3B interacting protein (GSKIP), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001271905.1

ORF Insert Sequence:

ATGGAAACAG ACTGTAATCC CATGGAGCTA AGCAGTATGT CAGGATTTGA AGAAGGTTCA 
GAGCTGAACG GTTTTGAAGG AACTGACATG AAAGACATGA GGCTCGAAGC TGAAGCAGTT 
GTAAATGATG TTCTCTTTGC TGTTAACAAC ATGTTTGTCT CGAAAAGCCT GCGGTGTGCG 
GATGATGTGG CCTATATCAA TGTGGAAACA AAGGAAAGAA ACAGATATTG CCTAGAACTC 
ACTGAAGCAG GGCTCAAGGT GGTAGGCTAT GCTTTTGACC AGGTAGATGA TCATTTACAG 
ACTCCCTACC ATGAAACAGT CTACTCCTTG TTGGATACAC TCAGCCCCGC CTACCGAGAA 
GCATTTGGAA ACGCACTGCT TCAAAGACTG GAAGCTTTGA AAAGAGATGG ACAGTCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GSKIP ( NM_016472.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_057556.2 Homo sapiens GSK3B interacting protein (GSKIP), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu01583
Clone ID Related Accession (Same CDS sequence)	NM_001271906.1 , XM_017021365.1 , NM_001271905.1 , NM_016472.4 , NM_016472.5 , NM_001271904.1 , XM_024449626.1
Accession Version	NM_016472.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 420bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1509379200000
Organism	Homo sapiens(human)
Product	GSK3B-interacting protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY051680.1, HY019704.1, AK000796.1, AL359240.4, AK094654.1 and W04717.1. On Dec 13, 2012 this sequence version replaced NM_016472.3. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.129758.1, SRR1660807.196753.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAAACAG ACTGTAATCC CATGGAGCTA AGCAGTATGT CAGGATTTGA AGAAGGTTCA 
GAGCTGAACG GTTTTGAAGG AACTGACATG AAAGACATGA GGCTCGAAGC TGAAGCAGTT 
GTAAATGATG TTCTCTTTGC TGTTAACAAC ATGTTTGTCT CGAAAAGCCT GCGGTGTGCG 
GATGATGTGG CCTATATCAA TGTGGAAACA AAGGAAAGAA ACAGATATTG CCTAGAACTC 
ACTGAAGCAG GGCTCAAGGT GGTAGGCTAT GCTTTTGACC AGGTAGATGA TCATTTACAG 
ACTCCCTACC ATGAAACAGT CTACTCCTTG TTGGATACAC TCAGCCCCGC CTACCGAGAA 
GCATTTGGAA ACGCACTGCT TCAAAGACTG GAAGCTTTGA AAAGAGATGG ACAGTCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057556.2
CDS	220..639
Translation	METDCNPMELSSMSGFEEGSELNGFEGTDMKDMRLEAEAVVNDVLFAVNNMFVSKSLRCADDVAYINVETKERNRYCLELTEAGLKVVGYAFDQVDDHLQTPYHETVYSLLDTLSPAYREAFGNALLQRLEALKRDGQS

Target ORF information:

RefSeq Version	NM_016472.4
Organism	Homo sapiens(human)
Definition	Homo sapiens GSK3B interacting protein (GSKIP), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016472.4

ORF Insert Sequence:

ATGGAAACAG ACTGTAATCC CATGGAGCTA AGCAGTATGT CAGGATTTGA AGAAGGTTCA 
GAGCTGAACG GTTTTGAAGG AACTGACATG AAAGACATGA GGCTCGAAGC TGAAGCAGTT 
GTAAATGATG TTCTCTTTGC TGTTAACAAC ATGTTTGTCT CGAAAAGCCT GCGGTGTGCG 
GATGATGTGG CCTATATCAA TGTGGAAACA AAGGAAAGAA ACAGATATTG CCTAGAACTC 
ACTGAAGCAG GGCTCAAGGT GGTAGGCTAT GCTTTTGACC AGGTAGATGA TCATTTACAG 
ACTCCCTACC ATGAAACAGT CTACTCCTTG TTGGATACAC TCAGCCCCGC CTACCGAGAA 
GCATTTGGAA ACGCACTGCT TCAAAGACTG GAAGCTTTGA AAAGAGATGG ACAGTCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GSKIP ( NM_016472.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_057556.2 Homo sapiens GSK3B interacting protein (GSKIP), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu01583
Clone ID Related Accession (Same CDS sequence)	NM_001271906.1 , XM_017021365.1 , NM_001271905.1 , NM_016472.4 , NM_016472.5 , NM_001271904.1 , XM_024449626.1
Accession Version	NM_016472.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 420bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1556640000000
Organism	Homo sapiens(human)
Product	GSK3B-interacting protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL359240.4. On Nov 23, 2018 this sequence version replaced NM_016472.4. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK000796.1, SRR1660805.148365.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000555181.6/ ENSP00000450420.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAAACAG ACTGTAATCC CATGGAGCTA AGCAGTATGT CAGGATTTGA AGAAGGTTCA 
GAGCTGAACG GTTTTGAAGG AACTGACATG AAAGACATGA GGCTCGAAGC TGAAGCAGTT 
GTAAATGATG TTCTCTTTGC TGTTAACAAC ATGTTTGTCT CGAAAAGCCT GCGGTGTGCG 
GATGATGTGG CCTATATCAA TGTGGAAACA AAGGAAAGAA ACAGATATTG CCTAGAACTC 
ACTGAAGCAG GGCTCAAGGT GGTAGGCTAT GCTTTTGACC AGGTAGATGA TCATTTACAG 
ACTCCCTACC ATGAAACAGT CTACTCCTTG TTGGATACAC TCAGCCCCGC CTACCGAGAA 
GCATTTGGAA ACGCACTGCT TCAAAGACTG GAAGCTTTGA AAAGAGATGG ACAGTCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057556.2
CDS	146..565
Translation	METDCNPMELSSMSGFEEGSELNGFEGTDMKDMRLEAEAVVNDVLFAVNNMFVSKSLRCADDVAYINVETKERNRYCLELTEAGLKVVGYAFDQVDDHLQTPYHETVYSLLDTLSPAYREAFGNALLQRLEALKRDGQS

Target ORF information:

RefSeq Version	NM_016472.5
Organism	Homo sapiens(human)
Definition	Homo sapiens GSK3B interacting protein (GSKIP), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016472.5

ORF Insert Sequence:

ATGGAAACAG ACTGTAATCC CATGGAGCTA AGCAGTATGT CAGGATTTGA AGAAGGTTCA 
GAGCTGAACG GTTTTGAAGG AACTGACATG AAAGACATGA GGCTCGAAGC TGAAGCAGTT 
GTAAATGATG TTCTCTTTGC TGTTAACAAC ATGTTTGTCT CGAAAAGCCT GCGGTGTGCG 
GATGATGTGG CCTATATCAA TGTGGAAACA AAGGAAAGAA ACAGATATTG CCTAGAACTC 
ACTGAAGCAG GGCTCAAGGT GGTAGGCTAT GCTTTTGACC AGGTAGATGA TCATTTACAG 
ACTCCCTACC ATGAAACAGT CTACTCCTTG TTGGATACAC TCAGCCCCGC CTACCGAGAA 
GCATTTGGAA ACGCACTGCT TCAAAGACTG GAAGCTTTGA AAAGAGATGG ACAGTCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GSKIP ( NM_001271904.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001258833.1 Homo sapiens GSK3B interacting protein (GSKIP), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu01583
Clone ID Related Accession (Same CDS sequence)	NM_001271906.1 , XM_017021365.1 , NM_001271905.1 , NM_016472.4 , NM_016472.5 , NM_001271904.1 , XM_024449626.1
Accession Version	NM_001271904.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 420bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1545408000000
Organism	Homo sapiens(human)
Product	GSK3B-interacting protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK094654.1, AL359240.4 and W04717.1. Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3 and 4 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK094654.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142586, SAMEA2144835 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAAACAG ACTGTAATCC CATGGAGCTA AGCAGTATGT CAGGATTTGA AGAAGGTTCA 
GAGCTGAACG GTTTTGAAGG AACTGACATG AAAGACATGA GGCTCGAAGC TGAAGCAGTT 
GTAAATGATG TTCTCTTTGC TGTTAACAAC ATGTTTGTCT CGAAAAGCCT GCGGTGTGCG 
GATGATGTGG CCTATATCAA TGTGGAAACA AAGGAAAGAA ACAGATATTG CCTAGAACTC 
ACTGAAGCAG GGCTCAAGGT GGTAGGCTAT GCTTTTGACC AGGTAGATGA TCATTTACAG 
ACTCCCTACC ATGAAACAGT CTACTCCTTG TTGGATACAC TCAGCCCCGC CTACCGAGAA 
GCATTTGGAA ACGCACTGCT TCAAAGACTG GAAGCTTTGA AAAGAGATGG ACAGTCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001258833.1
CDS	634..1053
Translation	METDCNPMELSSMSGFEEGSELNGFEGTDMKDMRLEAEAVVNDVLFAVNNMFVSKSLRCADDVAYINVETKERNRYCLELTEAGLKVVGYAFDQVDDHLQTPYHETVYSLLDTLSPAYREAFGNALLQRLEALKRDGQS

Target ORF information:

RefSeq Version	NM_001271904.1
Organism	Homo sapiens(human)
Definition	Homo sapiens GSK3B interacting protein (GSKIP), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001271904.1

ORF Insert Sequence:

ATGGAAACAG ACTGTAATCC CATGGAGCTA AGCAGTATGT CAGGATTTGA AGAAGGTTCA 
GAGCTGAACG GTTTTGAAGG AACTGACATG AAAGACATGA GGCTCGAAGC TGAAGCAGTT 
GTAAATGATG TTCTCTTTGC TGTTAACAAC ATGTTTGTCT CGAAAAGCCT GCGGTGTGCG 
GATGATGTGG CCTATATCAA TGTGGAAACA AAGGAAAGAA ACAGATATTG CCTAGAACTC 
ACTGAAGCAG GGCTCAAGGT GGTAGGCTAT GCTTTTGACC AGGTAGATGA TCATTTACAG 
ACTCCCTACC ATGAAACAGT CTACTCCTTG TTGGATACAC TCAGCCCCGC CTACCGAGAA 
GCATTTGGAA ACGCACTGCT TCAAAGACTG GAAGCTTTGA AAAGAGATGG ACAGTCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GSKIP ( XM_017021365.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016876854.1 Homo sapiens GSK3B interacting protein (GSKIP), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu01583
Clone ID Related Accession (Same CDS sequence)	NM_001271906.1 , XM_017021365.1 , NM_001271905.1 , NM_016472.4 , NM_016472.5 , NM_001271904.1 , XM_024449626.1
Accession Version	XM_017021365.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 420bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1521907200000
Organism	Homo sapiens(human)
Product	GSK3B-interacting protein isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000014.9) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Homo sapiens Annotation Release 109 Annotation Version :: 109 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAAACAG ACTGTAATCC CATGGAGCTA AGCAGTATGT CAGGATTTGA AGAAGGTTCA 
GAGCTGAACG GTTTTGAAGG AACTGACATG AAAGACATGA GGCTCGAAGC TGAAGCAGTT 
GTAAATGATG TTCTCTTTGC TGTTAACAAC ATGTTTGTCT CGAAAAGCCT GCGGTGTGCG 
GATGATGTGG CCTATATCAA TGTGGAAACA AAGGAAAGAA ACAGATATTG CCTAGAACTC 
ACTGAAGCAG GGCTCAAGGT GGTAGGCTAT GCTTTTGACC AGGTAGATGA TCATTTACAG 
ACTCCCTACC ATGAAACAGT CTACTCCTTG TTGGATACAC TCAGCCCCGC CTACCGAGAA 
GCATTTGGAA ACGCACTGCT TCAAAGACTG GAAGCTTTGA AAAGAGATGG ACAGTCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016876854.1
CDS	328..747
Translation	METDCNPMELSSMSGFEEGSELNGFEGTDMKDMRLEAEAVVNDVLFAVNNMFVSKSLRCADDVAYINVETKERNRYCLELTEAGLKVVGYAFDQVDDHLQTPYHETVYSLLDTLSPAYREAFGNALLQRLEALKRDGQS

Target ORF information:

RefSeq Version	XM_017021365.1
Organism	Homo sapiens(human)
Definition	Homo sapiens GSK3B interacting protein (GSKIP), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017021365.1

ORF Insert Sequence:

ATGGAAACAG ACTGTAATCC CATGGAGCTA AGCAGTATGT CAGGATTTGA AGAAGGTTCA 
GAGCTGAACG GTTTTGAAGG AACTGACATG AAAGACATGA GGCTCGAAGC TGAAGCAGTT 
GTAAATGATG TTCTCTTTGC TGTTAACAAC ATGTTTGTCT CGAAAAGCCT GCGGTGTGCG 
GATGATGTGG CCTATATCAA TGTGGAAACA AAGGAAAGAA ACAGATATTG CCTAGAACTC 
ACTGAAGCAG GGCTCAAGGT GGTAGGCTAT GCTTTTGACC AGGTAGATGA TCATTTACAG 
ACTCCCTACC ATGAAACAGT CTACTCCTTG TTGGATACAC TCAGCCCCGC CTACCGAGAA 
GCATTTGGAA ACGCACTGCT TCAAAGACTG GAAGCTTTGA AAAGAGATGG ACAGTCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GSKIP ( XM_024449626.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024305394.1 Homo sapiens GSK3B interacting protein (GSKIP), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu01583
Clone ID Related Accession (Same CDS sequence)	NM_001271906.1 , XM_017021365.1 , NM_001271905.1 , NM_016472.4 , NM_016472.5 , NM_001271904.1 , XM_024449626.1
Accession Version	XM_024449626.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 420bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1521907200000
Organism	Homo sapiens(human)
Product	GSK3B-interacting protein isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000014.9) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Homo sapiens Annotation Release 109 Annotation Version :: 109 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAAACAG ACTGTAATCC CATGGAGCTA AGCAGTATGT CAGGATTTGA AGAAGGTTCA 
GAGCTGAACG GTTTTGAAGG AACTGACATG AAAGACATGA GGCTCGAAGC TGAAGCAGTT 
GTAAATGATG TTCTCTTTGC TGTTAACAAC ATGTTTGTCT CGAAAAGCCT GCGGTGTGCG 
GATGATGTGG CCTATATCAA TGTGGAAACA AAGGAAAGAA ACAGATATTG CCTAGAACTC 
ACTGAAGCAG GGCTCAAGGT GGTAGGCTAT GCTTTTGACC AGGTAGATGA TCATTTACAG 
ACTCCCTACC ATGAAACAGT CTACTCCTTG TTGGATACAC TCAGCCCCGC CTACCGAGAA 
GCATTTGGAA ACGCACTGCT TCAAAGACTG GAAGCTTTGA AAAGAGATGG ACAGTCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024305394.1
CDS	354..773
Translation	METDCNPMELSSMSGFEEGSELNGFEGTDMKDMRLEAEAVVNDVLFAVNNMFVSKSLRCADDVAYINVETKERNRYCLELTEAGLKVVGYAFDQVDDHLQTPYHETVYSLLDTLSPAYREAFGNALLQRLEALKRDGQS

Target ORF information:

RefSeq Version	XM_024449626.1
Organism	Homo sapiens(human)
Definition	Homo sapiens GSK3B interacting protein (GSKIP), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024449626.1

ORF Insert Sequence:

ATGGAAACAG ACTGTAATCC CATGGAGCTA AGCAGTATGT CAGGATTTGA AGAAGGTTCA 
GAGCTGAACG GTTTTGAAGG AACTGACATG AAAGACATGA GGCTCGAAGC TGAAGCAGTT 
GTAAATGATG TTCTCTTTGC TGTTAACAAC ATGTTTGTCT CGAAAAGCCT GCGGTGTGCG 
GATGATGTGG CCTATATCAA TGTGGAAACA AAGGAAAGAA ACAGATATTG CCTAGAACTC 
ACTGAAGCAG GGCTCAAGGT GGTAGGCTAT GCTTTTGACC AGGTAGATGA TCATTTACAG 
ACTCCCTACC ATGAAACAGT CTACTCCTTG TTGGATACAC TCAGCCCCGC CTACCGAGAA 
GCATTTGGAA ACGCACTGCT TCAAAGACTG GAAGCTTTGA AAAGAGATGG ACAGTCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The origin of GSKIP, a multifaceted regulatory factor in the mammalian Wnt pathway.
Biochimica et biophysica acta. Molecular cell research1865(8)1046-1059(2018 08)
Chou CH,Yang MC,Hsiao BX,Wang YH,Liu HF,Chiou SJ,Chuang YC,Yang CN,Lieu AS,Loh JK,Howng SL,Chou AK,Tseng CN,Cheng JT,Hong YR

An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations.
Nature communications9(1)1188(2018 03)
Liu X,Salokas K,Tamene F,Jiu Y,Weldatsadik RG,Öhman T,Varjosalo M

The A-Kinase Anchoring Protein (AKAP) Glycogen Synthase Kinase 3β Interaction Protein (GSKIP) Regulates β-Catenin through Its Interactions with Both Protein Kinase A (PKA) and GSK3β.
The Journal of biological chemistry291(37)19618-30(2016 09)
Dema A,Schröter MF,Perets E,Skroblin P,Moutty MC,Deàk VA,Birchmeier W,Klussmann E

Germline duplication of ATG2B and GSKIP predisposes to familial myeloid malignancies.
Nature genetics47(10)1131-40(2015 Oct)
Saliba J,Saint-Martin C,Di Stefano A,Lenglet G,Marty C,Keren B,Pasquier F,Valle VD,Secardin L,Leroy G,Mahfoudhi E,Grosjean S,Droin N,Diop M,Dessen P,Charrier S,Palazzo A,Merlevede J,Meniane JC,Delaunay-Darivon C,Fuseau P,Isnard F,Casadevall N,Solary E,Debili N,Bernard OA,Raslova H,Najman A,Vainchenker W,Bellanné-Chantelot C,Plo I

GSKIP- and GSK3-mediated anchoring strengthens cAMP/PKA/Drp1 axis signaling in the regulation of mitochondrial elongation.
Biochimica et biophysica acta1853(8)1796-807(2015 Aug)
Loh JK,Lin CC,Yang MC,Chou CH,Chen WS,Hong MC,Cho CL,Hsu CM,Cheng JT,Chou AK,Chang CH,Tseng CN,Wang CH,Lieu AS,Howng SL,Hong YR

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GSKIP cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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Target ORF information:

ORF Insert Sequence:

Target ORF information:

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