AHSP cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	AHSP
Entrez Gene ID	51327
Full Name	alpha hemoglobin stabilizing protein
Synonyms	EDRF,ERAF
General protein information	Preferred Names alpha hemoglobin stabilizing protein Names alpha-hemoglobin-stabilizing protein alpha hemoglobin stabilising protein erythroid differentiation associated factor erythroid differentiation-related factor
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16p11.2
Summary	This gene encodes a molecular chaperone which binds specifically to free alpha-globin and is involved in hemoglobin assembly. The encoded protein binds to monomeric alpha-globin until it has been transferred to beta-globin to form a heterodimer, which in turn binds to another heterodimer to form the stable tetrameric hemoglobin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015].
Disorder MIM:	605821

mRNA and Protein(s)

mRNA	Protein	Name
XM_005255352.2	XP_005255409.1	alpha-hemoglobin-stabilizing protein isoform X1
NM_016633.2	NP_057717.1	alpha-hemoglobin-stabilizing protein
NM_016633.3	NP_057717.1	alpha-hemoglobin-stabilizing protein
NM_001318221.1	NP_001305150.1	alpha-hemoglobin-stabilizing protein
NM_001318222.1	NP_001305151.1	alpha-hemoglobin-stabilizing protein
NM_001318221.2	NP_001305150.1	alpha-hemoglobin-stabilizing protein
XM_005255351.3	XP_005255408.1	alpha-hemoglobin-stabilizing protein isoform X1
NM_016633.4	NP_057717.1	alpha-hemoglobin-stabilizing protein

Pathways from BioSystems

Homologies

Homo sapiens (human)	AHSP	NP_057717.1
Pan troglodytes (chimpanzee)	AHSP	XP_001159573.1
Canis lupus familiaris (dog)	AHSP	XP_003434819.1
Bos taurus (cattle)	AHSP	NP_803488.1
Rattus norvegicus (Norway rat)	Ahsp	NP_001099769.1
Macaca mulatta (Rhesus monkey)	AHSP	XP_001113388.1

Gene Ontology
Bibliography

Related articles in PubMed

Association of alpha hemoglobin-stabilizing protein (AHSP) gene mutation and disease severity among HbE-beta thalassemia patients.
Ray R, Kalantri SA, Bhattacharjee S, Biswas A, Shahab A, Biswas S, Bhattacharyya M
Annals of hematology98(8)1827-1834(2019 Aug)

A molecular study on the role of alpha-hemoglobin-stabilizing protein in hemoglobin H disease.
Surapolchai P, Chuansumrit A, Sirachainan N, Kadegasem P, Leung KC, So CC
Annals of hematology96(6)1005-1014(2017 Jun)

Oxidative instability of hemoglobin E (β26 Glu→Lys) is increased in the presence of free α subunits and reversed by α-hemoglobin stabilizing protein (AHSP): Relevance to HbE/β-thalassemia.
Strader MB, Kassa T, Meng F, Wood FB, Hirsch RE, Friedman JM, Alayash AI
Redox biology8363-74(2016 08)

Study of alpha hemoglobin stabilizing protein expression in patients with β thalassemia and sickle cell anemia and its impact on clinical severity.
Mahmoud HM, Shoeib AA, Abd El Ghany SM, Reda MM, Ragab IA
Blood cells, molecules & diseases55(4)358-62(2015 Dec)

Review: Beta-thalassemia and molecular chaperones.
Sumera A, Radhakrishnan A, Baba AA, George E
Blood cells, molecules & diseases54(4)348-52(2015 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following AHSP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the AHSP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu07308	NM_001318221.2 Latest version!	Homo sapiens alpha hemoglobin stabilizing protein (AHSP), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
OHu07308	NM_001318222.1 Latest version!	Homo sapiens alpha hemoglobin stabilizing protein (AHSP), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
OHu07308	NM_016633.4 Latest version!	Homo sapiens alpha hemoglobin stabilizing protein (AHSP), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
OHu07308	XM_005255352.2 Latest version!	Homo sapiens alpha hemoglobin stabilizing protein (AHSP), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
OHu07308	XM_005255351.3 Latest version!	Homo sapiens alpha hemoglobin stabilizing protein (AHSP), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
View Old Accession Versions >>
OHu07308	NM_016633.2	Homo sapiens alpha hemoglobin stabilizing protein (AHSP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
OHu07308	NM_001318221.1	Homo sapiens alpha hemoglobin stabilizing protein (AHSP), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
OHu07308	NM_016633.3	Homo sapiens alpha hemoglobin stabilizing protein (AHSP), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

AHSP ( NM_016633.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_057717.1 Homo sapiens alpha hemoglobin stabilizing protein (AHSP), mRNA.

Price & Availability↑

CloneID	OHu07308
Clone ID Related Accession (Same CDS sequence)	XM_005255352.2 , NM_016633.2 , NM_016633.3 , NM_001318221.1 , NM_001318222.1 , NM_001318221.2 , XM_005255351.3 , NM_016633.4
Accession Version	NM_016633.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 309bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1426262400000
Organism	Homo sapiens(Human)
Product	alpha-hemoglobin-stabilizing protein
Comment

ATGGCTCTTC TTAAGGCCAA TAAGGATCTC ATTTCCGCAG GATTGAAGGA GTTCAGCGTT 
CTGCTGAATC AGCAGGTCTT CAATGATCCT CTCGTCTCTG AAGAAGACAT GGTGACTGTG 
GTGGAGGACT GGATGAACTT CTACATCAAC TATTACAGGC AGCAGGTGAC AGGGGAGCCC 
CAAGAGCGAG ACAAGGCTCT GCAGGAGCTT CGGCAAGAGC TGAACACTCT GGCCAACCCT 
TTCCTGGCCA AGTACAGGGA CTTCCTGAAG TCTCATGAGC TCCCGAGTCA CCCACCGCCC 
TCCTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057717.1
Translation	MALLKANKDLISAGLKEFSVLLNQQVFNDPLVSEEDMVTVVEDWMNFYINYYRQQVTGEPQERDKALQELRQELNTLANPFLAKYRDFLKSHELPSHPPPSS

Target ORF information:

RefSeq Version	NM_016633.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens alpha hemoglobin stabilizing protein (AHSP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016633.2

ORF Insert Sequence:

ATGGCTCTTC TTAAGGCCAA TAAGGATCTC ATTTCCGCAG GATTGAAGGA GTTCAGCGTT 
CTGCTGAATC AGCAGGTCTT CAATGATCCT CTCGTCTCTG AAGAAGACAT GGTGACTGTG 
GTGGAGGACT GGATGAACTT CTACATCAAC TATTACAGGC AGCAGGTGAC AGGGGAGCCC 
CAAGAGCGAG ACAAGGCTCT GCAGGAGCTT CGGCAAGAGC TGAACACTCT GGCCAACCCT 
TTCCTGGCCA AGTACAGGGA CTTCCTGAAG TCTCATGAGC TCCCGAGTCA CCCACCGCCC 
TCCTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AHSP ( NM_016633.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_057717.1 Homo sapiens alpha hemoglobin stabilizing protein (AHSP), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu07308
Clone ID Related Accession (Same CDS sequence)	XM_005255352.2 , NM_016633.2 , NM_016633.3 , NM_001318221.1 , NM_001318222.1 , NM_001318221.2 , XM_005255351.3 , NM_016633.4
Accession Version	NM_016633.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 309bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1511884800000
Organism	Homo sapiens(human)
Product	alpha-hemoglobin-stabilizing protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC106730.2, H94920.1, BG940214.1, AF112995.1 and BG944022.1. This sequence is a reference standard in the RefSeqGene project. On Dec 30, 2015 this sequence version replaced NM_016633.2. Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF112995.1, BG942683.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2142853 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTCTTC TTAAGGCCAA TAAGGATCTC ATTTCCGCAG GATTGAAGGA GTTCAGCGTT 
CTGCTGAATC AGCAGGTCTT CAATGATCCT CTCGTCTCTG AAGAAGACAT GGTGACTGTG 
GTGGAGGACT GGATGAACTT CTACATCAAC TATTACAGGC AGCAGGTGAC AGGGGAGCCC 
CAAGAGCGAG ACAAGGCTCT GCAGGAGCTT CGGCAAGAGC TGAACACTCT GGCCAACCCT 
TTCCTGGCCA AGTACAGGGA CTTCCTGAAG TCTCATGAGC TCCCGAGTCA CCCACCGCCC 
TCCTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057717.1
CDS	116..424
Translation	MALLKANKDLISAGLKEFSVLLNQQVFNDPLVSEEDMVTVVEDWMNFYINYYRQQVTGEPQERDKALQELRQELNTLANPFLAKYRDFLKSHELPSHPPPSS

Target ORF information:

RefSeq Version	NM_016633.3
Organism	Homo sapiens(human)
Definition	Homo sapiens alpha hemoglobin stabilizing protein (AHSP), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016633.3

ORF Insert Sequence:

ATGGCTCTTC TTAAGGCCAA TAAGGATCTC ATTTCCGCAG GATTGAAGGA GTTCAGCGTT 
CTGCTGAATC AGCAGGTCTT CAATGATCCT CTCGTCTCTG AAGAAGACAT GGTGACTGTG 
GTGGAGGACT GGATGAACTT CTACATCAAC TATTACAGGC AGCAGGTGAC AGGGGAGCCC 
CAAGAGCGAG ACAAGGCTCT GCAGGAGCTT CGGCAAGAGC TGAACACTCT GGCCAACCCT 
TTCCTGGCCA AGTACAGGGA CTTCCTGAAG TCTCATGAGC TCCCGAGTCA CCCACCGCCC 
TCCTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AHSP ( NM_001318221.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001305150.1 Homo sapiens alpha hemoglobin stabilizing protein (AHSP), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu07308
Clone ID Related Accession (Same CDS sequence)	XM_005255352.2 , NM_016633.2 , NM_016633.3 , NM_001318221.1 , NM_001318222.1 , NM_001318221.2 , XM_005255351.3 , NM_016633.4
Accession Version	NM_001318221.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 309bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1530288000000
Organism	Homo sapiens(human)
Product	alpha-hemoglobin-stabilizing protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC106730.2, H94920.1, BG943964.1, AF112995.1 and BG944022.1. On Dec 30, 2015 this sequence version replaced XM_005255352.2. Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BG943419.1, BG942798.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2142853 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTCTTC TTAAGGCCAA TAAGGATCTC ATTTCCGCAG GATTGAAGGA GTTCAGCGTT 
CTGCTGAATC AGCAGGTCTT CAATGATCCT CTCGTCTCTG AAGAAGACAT GGTGACTGTG 
GTGGAGGACT GGATGAACTT CTACATCAAC TATTACAGGC AGCAGGTGAC AGGGGAGCCC 
CAAGAGCGAG ACAAGGCTCT GCAGGAGCTT CGGCAAGAGC TGAACACTCT GGCCAACCCT 
TTCCTGGCCA AGTACAGGGA CTTCCTGAAG TCTCATGAGC TCCCGAGTCA CCCACCGCCC 
TCCTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001305150.1
CDS	112..420
Translation	MALLKANKDLISAGLKEFSVLLNQQVFNDPLVSEEDMVTVVEDWMNFYINYYRQQVTGEPQERDKALQELRQELNTLANPFLAKYRDFLKSHELPSHPPPSS

Target ORF information:

RefSeq Version	NM_001318221.1
Organism	Homo sapiens(human)
Definition	Homo sapiens alpha hemoglobin stabilizing protein (AHSP), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001318221.1

ORF Insert Sequence:

ATGGCTCTTC TTAAGGCCAA TAAGGATCTC ATTTCCGCAG GATTGAAGGA GTTCAGCGTT 
CTGCTGAATC AGCAGGTCTT CAATGATCCT CTCGTCTCTG AAGAAGACAT GGTGACTGTG 
GTGGAGGACT GGATGAACTT CTACATCAAC TATTACAGGC AGCAGGTGAC AGGGGAGCCC 
CAAGAGCGAG ACAAGGCTCT GCAGGAGCTT CGGCAAGAGC TGAACACTCT GGCCAACCCT 
TTCCTGGCCA AGTACAGGGA CTTCCTGAAG TCTCATGAGC TCCCGAGTCA CCCACCGCCC 
TCCTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AHSP ( NM_001318222.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001305151.1 Homo sapiens alpha hemoglobin stabilizing protein (AHSP), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu07308
Clone ID Related Accession (Same CDS sequence)	XM_005255352.2 , NM_016633.2 , NM_016633.3 , NM_001318221.1 , NM_001318222.1 , NM_001318221.2 , XM_005255351.3 , NM_016633.4
Accession Version	NM_001318222.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 309bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1569254400000
Organism	Homo sapiens(human)
Product	alpha-hemoglobin-stabilizing protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from R29304.1, AF112995.1 and BG944022.1. On Dec 30, 2015 this sequence version replaced XM_005255351.3. Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: R29304.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893, SAMEA2149004 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTCTTC TTAAGGCCAA TAAGGATCTC ATTTCCGCAG GATTGAAGGA GTTCAGCGTT 
CTGCTGAATC AGCAGGTCTT CAATGATCCT CTCGTCTCTG AAGAAGACAT GGTGACTGTG 
GTGGAGGACT GGATGAACTT CTACATCAAC TATTACAGGC AGCAGGTGAC AGGGGAGCCC 
CAAGAGCGAG ACAAGGCTCT GCAGGAGCTT CGGCAAGAGC TGAACACTCT GGCCAACCCT 
TTCCTGGCCA AGTACAGGGA CTTCCTGAAG TCTCATGAGC TCCCGAGTCA CCCACCGCCC 
TCCTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001305151.1
CDS	43..351
Translation	MALLKANKDLISAGLKEFSVLLNQQVFNDPLVSEEDMVTVVEDWMNFYINYYRQQVTGEPQERDKALQELRQELNTLANPFLAKYRDFLKSHELPSHPPPSS

Target ORF information:

RefSeq Version	NM_001318222.1
Organism	Homo sapiens(human)
Definition	Homo sapiens alpha hemoglobin stabilizing protein (AHSP), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001318222.1

ORF Insert Sequence:

ATGGCTCTTC TTAAGGCCAA TAAGGATCTC ATTTCCGCAG GATTGAAGGA GTTCAGCGTT 
CTGCTGAATC AGCAGGTCTT CAATGATCCT CTCGTCTCTG AAGAAGACAT GGTGACTGTG 
GTGGAGGACT GGATGAACTT CTACATCAAC TATTACAGGC AGCAGGTGAC AGGGGAGCCC 
CAAGAGCGAG ACAAGGCTCT GCAGGAGCTT CGGCAAGAGC TGAACACTCT GGCCAACCCT 
TTCCTGGCCA AGTACAGGGA CTTCCTGAAG TCTCATGAGC TCCCGAGTCA CCCACCGCCC 
TCCTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AHSP ( NM_001318221.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001305150.1 Homo sapiens alpha hemoglobin stabilizing protein (AHSP), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu07308
Clone ID Related Accession (Same CDS sequence)	XM_005255352.2 , NM_016633.2 , NM_016633.3 , NM_001318221.1 , NM_001318222.1 , NM_001318221.2 , XM_005255351.3 , NM_016633.4
Accession Version	NM_001318221.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 309bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1569513600000
Organism	Homo sapiens(human)
Product	alpha-hemoglobin-stabilizing protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from H94920.1, BG943964.1 and AF112995.1. On May 31, 2019 this sequence version replaced NM_001318221.1. Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BG942798.1, BG943419.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2142853 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTCTTC TTAAGGCCAA TAAGGATCTC ATTTCCGCAG GATTGAAGGA GTTCAGCGTT 
CTGCTGAATC AGCAGGTCTT CAATGATCCT CTCGTCTCTG AAGAAGACAT GGTGACTGTG 
GTGGAGGACT GGATGAACTT CTACATCAAC TATTACAGGC AGCAGGTGAC AGGGGAGCCC 
CAAGAGCGAG ACAAGGCTCT GCAGGAGCTT CGGCAAGAGC TGAACACTCT GGCCAACCCT 
TTCCTGGCCA AGTACAGGGA CTTCCTGAAG TCTCATGAGC TCCCGAGTCA CCCACCGCCC 
TCCTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001305150.1
CDS	64..372
Translation	MALLKANKDLISAGLKEFSVLLNQQVFNDPLVSEEDMVTVVEDWMNFYINYYRQQVTGEPQERDKALQELRQELNTLANPFLAKYRDFLKSHELPSHPPPSS

Target ORF information:

RefSeq Version	NM_001318221.2
Organism	Homo sapiens(human)
Definition	Homo sapiens alpha hemoglobin stabilizing protein (AHSP), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001318221.2

ORF Insert Sequence:

ATGGCTCTTC TTAAGGCCAA TAAGGATCTC ATTTCCGCAG GATTGAAGGA GTTCAGCGTT 
CTGCTGAATC AGCAGGTCTT CAATGATCCT CTCGTCTCTG AAGAAGACAT GGTGACTGTG 
GTGGAGGACT GGATGAACTT CTACATCAAC TATTACAGGC AGCAGGTGAC AGGGGAGCCC 
CAAGAGCGAG ACAAGGCTCT GCAGGAGCTT CGGCAAGAGC TGAACACTCT GGCCAACCCT 
TTCCTGGCCA AGTACAGGGA CTTCCTGAAG TCTCATGAGC TCCCGAGTCA CCCACCGCCC 
TCCTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AHSP ( NM_016633.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_057717.1 Homo sapiens alpha hemoglobin stabilizing protein (AHSP), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu07308
Clone ID Related Accession (Same CDS sequence)	XM_005255352.2 , NM_016633.2 , NM_016633.3 , NM_001318221.1 , NM_001318222.1 , NM_001318221.2 , XM_005255351.3 , NM_016633.4
Accession Version	NM_016633.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 309bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1569513600000
Organism	Homo sapiens(human)
Product	alpha-hemoglobin-stabilizing protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG940214.1 and AF112995.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_016633.3. Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF112995.1, AF147435.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2142853 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000302312.9/ ENSP00000307199.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTCTTC TTAAGGCCAA TAAGGATCTC ATTTCCGCAG GATTGAAGGA GTTCAGCGTT 
CTGCTGAATC AGCAGGTCTT CAATGATCCT CTCGTCTCTG AAGAAGACAT GGTGACTGTG 
GTGGAGGACT GGATGAACTT CTACATCAAC TATTACAGGC AGCAGGTGAC AGGGGAGCCC 
CAAGAGCGAG ACAAGGCTCT GCAGGAGCTT CGGCAAGAGC TGAACACTCT GGCCAACCCT 
TTCCTGGCCA AGTACAGGGA CTTCCTGAAG TCTCATGAGC TCCCGAGTCA CCCACCGCCC 
TCCTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057717.1
CDS	68..376
Translation	MALLKANKDLISAGLKEFSVLLNQQVFNDPLVSEEDMVTVVEDWMNFYINYYRQQVTGEPQERDKALQELRQELNTLANPFLAKYRDFLKSHELPSHPPPSS

Target ORF information:

RefSeq Version	NM_016633.4
Organism	Homo sapiens(human)
Definition	Homo sapiens alpha hemoglobin stabilizing protein (AHSP), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016633.4

ORF Insert Sequence:

ATGGCTCTTC TTAAGGCCAA TAAGGATCTC ATTTCCGCAG GATTGAAGGA GTTCAGCGTT 
CTGCTGAATC AGCAGGTCTT CAATGATCCT CTCGTCTCTG AAGAAGACAT GGTGACTGTG 
GTGGAGGACT GGATGAACTT CTACATCAAC TATTACAGGC AGCAGGTGAC AGGGGAGCCC 
CAAGAGCGAG ACAAGGCTCT GCAGGAGCTT CGGCAAGAGC TGAACACTCT GGCCAACCCT 
TTCCTGGCCA AGTACAGGGA CTTCCTGAAG TCTCATGAGC TCCCGAGTCA CCCACCGCCC 
TCCTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AHSP ( XM_005255352.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_005255409.1 Homo sapiens alpha hemoglobin stabilizing protein (AHSP), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu07308
Clone ID Related Accession (Same CDS sequence)	XM_005255352.2 , NM_016633.2 , NM_016633.3 , NM_001318221.1 , NM_001318222.1 , NM_001318221.2 , XM_005255351.3 , NM_016633.4
Accession Version	XM_005255352.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 309bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1426003200000
Organism	Homo sapiens(Human)
Product	alpha-hemoglobin-stabilizing protein isoform X1
Comment

ATGGCTCTTC TTAAGGCCAA TAAGGATCTC ATTTCCGCAG GATTGAAGGA GTTCAGCGTT 
CTGCTGAATC AGCAGGTCTT CAATGATCCT CTCGTCTCTG AAGAAGACAT GGTGACTGTG 
GTGGAGGACT GGATGAACTT CTACATCAAC TATTACAGGC AGCAGGTGAC AGGGGAGCCC 
CAAGAGCGAG ACAAGGCTCT GCAGGAGCTT CGGCAAGAGC TGAACACTCT GGCCAACCCT 
TTCCTGGCCA AGTACAGGGA CTTCCTGAAG TCTCATGAGC TCCCGAGTCA CCCACCGCCC 
TCCTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005255409.1
Translation	MALLKANKDLISAGLKEFSVLLNQQVFNDPLVSEEDMVTVVEDWMNFYINYYRQQVTGEPQERDKALQELRQELNTLANPFLAKYRDFLKSHELPSHPPPSS

Target ORF information:

RefSeq Version	XM_005255352.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens alpha hemoglobin stabilizing protein (AHSP), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005255352.2

ORF Insert Sequence:

ATGGCTCTTC TTAAGGCCAA TAAGGATCTC ATTTCCGCAG GATTGAAGGA GTTCAGCGTT 
CTGCTGAATC AGCAGGTCTT CAATGATCCT CTCGTCTCTG AAGAAGACAT GGTGACTGTG 
GTGGAGGACT GGATGAACTT CTACATCAAC TATTACAGGC AGCAGGTGAC AGGGGAGCCC 
CAAGAGCGAG ACAAGGCTCT GCAGGAGCTT CGGCAAGAGC TGAACACTCT GGCCAACCCT 
TTCCTGGCCA AGTACAGGGA CTTCCTGAAG TCTCATGAGC TCCCGAGTCA CCCACCGCCC 
TCCTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AHSP ( XM_005255351.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_005255408.1 Homo sapiens alpha hemoglobin stabilizing protein (AHSP), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu07308
Clone ID Related Accession (Same CDS sequence)	XM_005255352.2 , NM_016633.2 , NM_016633.3 , NM_001318221.1 , NM_001318222.1 , NM_001318221.2 , XM_005255351.3 , NM_016633.4
Accession Version	XM_005255351.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 309bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1426003200000
Organism	Homo sapiens(Human)
Product	alpha-hemoglobin-stabilizing protein isoform X1
Comment

ATGGCTCTTC TTAAGGCCAA TAAGGATCTC ATTTCCGCAG GATTGAAGGA GTTCAGCGTT 
CTGCTGAATC AGCAGGTCTT CAATGATCCT CTCGTCTCTG AAGAAGACAT GGTGACTGTG 
GTGGAGGACT GGATGAACTT CTACATCAAC TATTACAGGC AGCAGGTGAC AGGGGAGCCC 
CAAGAGCGAG ACAAGGCTCT GCAGGAGCTT CGGCAAGAGC TGAACACTCT GGCCAACCCT 
TTCCTGGCCA AGTACAGGGA CTTCCTGAAG TCTCATGAGC TCCCGAGTCA CCCACCGCCC 
TCCTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005255408.1
Translation	MALLKANKDLISAGLKEFSVLLNQQVFNDPLVSEEDMVTVVEDWMNFYINYYRQQVTGEPQERDKALQELRQELNTLANPFLAKYRDFLKSHELPSHPPPSS

Target ORF information:

RefSeq Version	XM_005255351.3
Organism	Homo sapiens(Human)
Definition	Homo sapiens alpha hemoglobin stabilizing protein (AHSP), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005255351.3

ORF Insert Sequence:

ATGGCTCTTC TTAAGGCCAA TAAGGATCTC ATTTCCGCAG GATTGAAGGA GTTCAGCGTT 
CTGCTGAATC AGCAGGTCTT CAATGATCCT CTCGTCTCTG AAGAAGACAT GGTGACTGTG 
GTGGAGGACT GGATGAACTT CTACATCAAC TATTACAGGC AGCAGGTGAC AGGGGAGCCC 
CAAGAGCGAG ACAAGGCTCT GCAGGAGCTT CGGCAAGAGC TGAACACTCT GGCCAACCCT 
TTCCTGGCCA AGTACAGGGA CTTCCTGAAG TCTCATGAGC TCCCGAGTCA CCCACCGCCC 
TCCTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Association of alpha hemoglobin-stabilizing protein (AHSP) gene mutation and disease severity among HbE-beta thalassemia patients.
Annals of hematology98(8)1827-1834(2019 Aug)
Ray R,Kalantri SA,Bhattacharjee S,Biswas A,Shahab A,Biswas S,Bhattacharyya M

A molecular study on the role of alpha-hemoglobin-stabilizing protein in hemoglobin H disease.
Annals of hematology96(6)1005-1014(2017 Jun)
Surapolchai P,Chuansumrit A,Sirachainan N,Kadegasem P,Leung KC,So CC

Oxidative instability of hemoglobin E (β26 Glu→Lys) is increased in the presence of free α subunits and reversed by α-hemoglobin stabilizing protein (AHSP): Relevance to HbE/β-thalassemia.
Redox biology8363-74(2016 08)
Strader MB,Kassa T,Meng F,Wood FB,Hirsch RE,Friedman JM,Alayash AI

Study of alpha hemoglobin stabilizing protein expression in patients with β thalassemia and sickle cell anemia and its impact on clinical severity.
Blood cells, molecules & diseases55(4)358-62(2015 Dec)
Mahmoud HM,Shoeib AA,Abd El Ghany SM,Reda MM,Ragab IA

Review: Beta-thalassemia and molecular chaperones.
Blood cells, molecules & diseases54(4)348-52(2015 Apr)
Sumera A,Radhakrishnan A,Baba AA,George E

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AHSP cDNA ORF clone, Homo sapiens(human)

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ORF Insert Sequence:

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