| Gene Symbol | ATP6V0A4 |
| Entrez Gene ID | 50617 |
| Full Name | ATPase H+ transporting V0 subunit a4 |
| Synonyms | A4,ATP6N1B,ATP6N2,RDRTA2,RTA1C,RTADR,STV1,VPH1,VPP2 |
| General protein information |
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| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. This gene is one of four genes in man and mouse that encode different isoforms of the a subunit. Alternatively spliced transcript variants encoding the same protein have been described. Mutations in this gene are associated with renal tubular acidosis associated with preserved hearing. [provided by RefSeq, Jul 2008]. |
| Disorder MIM: | |
| Disorder Html: | Renal tubular acidosis, distal, autosomal recessive, 602722 (3) |

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