| Gene Symbol | NEU1 |
| Entrez Gene ID | 4758 |
| Full Name | neuraminidase 1 |
| Synonyms | NANH,NEU,SIAL1 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | The protein encoded by this gene is a lysosomal enzyme that cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. In the lysosome, this enzyme is part of a heterotrimeric complex together with beta-galactosidase and cathepsin A (the latter is also referred to as 'protective protein'). Mutations in this gene can lead to sialidosis, a lysosomal storage disease that can be type 1 (cherry red spot-myoclonus syndrome or normosomatic type), which is late-onset, or type 2 (the dysmorphic type), which occurs at an earlier age with increased severity. [provided by RefSeq, Jul 2008]. |
| Disorder MIM: | |
| Disorder Html: | Sialidosis, type I, 256550 (3); Sialidosis, type II, 256550 (3) |
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NEU1 cDNA ORF clone, Homo sapiens(human)
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Gene
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Clones
gRNAs
The following NEU1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NEU1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OHu26827 Clone ID Related Accession (Same CDS sequence) NM_000434.3 , NM_000434.4 Accession Version NM_000434.3 Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 1248bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1551542400000 Organism Homo sapiens(human) Product sialidase-1 precursor Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB122914.1, BC000722.2 and CA428930.1. This sequence is a reference standard in the RefSeqGene project. On May 31, 2008 this sequence version replaced NM_000434.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.103553.1, SRR1803611.166177.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201ATGACTGGGG AGCGACCCAG CACGGCGCTC CCGGACAGAC GCTGGGGGCC GCGGATTCTG
GGCTTCTGGG GAGGCTGTAG GGTTTGGGTG TTTGCCGCGA TCTTCCTGCT GCTGTCTCTG
GCAGCCTCCT GGTCCAAGGC TGAGAACGAC TTCGGTCTGG TGCAGCCGCT GGTGACCATG
GAGCAACTGC TGTGGGTGAG CGGGAGACAG ATCGGCTCAG TGGACACCTT CCGCATCCCG
CTCATCACAG CCACTCCGCG GGGCACTCTT CTCGCCTTTG CTGAGGCGAG GAAAATGTCC
TCATCCGATG AGGGGGCCAA GTTCATCGCC CTGCGGAGGT CCATGGACCA GGGCAGCACA
TGGTCTCCTA CAGCGTTCAT TGTCAATGAT GGGGATGTCC CCGATGGGCT GAACCTTGGG
GCAGTAGTGA GCGATGTTGA GACAGGAGTA GTATTTCTTT TCTACTCCCT TTGTGCTCAC
AAGGCCGGCT GCCAGGTGGC CTCTACCATG TTGGTATGGA GCAAGGATGA TGGTGTTTCC
TGGAGCACAC CCCGGAATCT CTCCCTGGAT ATTGGCACTG AAGTGTTTGC CCCTGGACCG
GGCTCTGGTA TTCAGAAACA GCGGGAGCCA CGGAAGGGCC GCCTCATCGT GTGTGGCCAT
GGGACGCTGG AGCGGGACGG AGTCTTCTGT CTCCTCAGCG ATGATCATGG TGCCTCCTGG
CGCTACGGAA GTGGGGTCAG CGGCATCCCC TACGGTCAGC CCAAGCAGGA AAATGATTTC
AATCCTGATG AATGCCAGCC CTATGAGCTC CCAGATGGCT CAGTCGTCAT CAATGCCCGA
AACCAGAACA ACTACCACTG CCACTGCCGA ATTGTCCTCC GCAGCTATGA TGCCTGTGAT
ACACTAAGGC CCCGTGATGT GACCTTCGAC CCTGAGCTCG TGGACCCTGT GGTAGCTGCA
GGAGCTGTAG TCACCAGCTC CGGCATTGTC TTCTTCTCCA ACCCAGCACA TCCAGAGTTC
CGAGTGAACC TGACCCTGCG ATGGAGCTTC AGCAATGGTA CCTCATGGCG GAAAGAGACA
GTCCAGCTAT GGCCAGGCCC CAGTGGCTAT TCATCCCTGG CAACCCTGGA GGGCAGCATG
GATGGAGAGG AGCAGGCCCC CCAGCTCTAC GTCCTGTATG AGAAAGGCCG GAACCACTAC
ACAGAGAGCA TCTCCGTGGC CAAAATCAGT GTCTATGGGA CACTCTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_000425.1 CDS 157..1404 Translation 
Target ORF information:
RefSeq Version NM_000434.3 Organism Homo sapiens(human) Definition Homo sapiens neuraminidase 1 (NEU1), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_000434.3
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201ATGACTGGGG AGCGACCCAG CACGGCGCTC CCGGACAGAC GCTGGGGGCC GCGGATTCTG
GGCTTCTGGG GAGGCTGTAG GGTTTGGGTG TTTGCCGCGA TCTTCCTGCT GCTGTCTCTG
GCAGCCTCCT GGTCCAAGGC TGAGAACGAC TTCGGTCTGG TGCAGCCGCT GGTGACCATG
GAGCAACTGC TGTGGGTGAG CGGGAGACAG ATCGGCTCAG TGGACACCTT CCGCATCCCG
CTCATCACAG CCACTCCGCG GGGCACTCTT CTCGCCTTTG CTGAGGCGAG GAAAATGTCC
TCATCCGATG AGGGGGCCAA GTTCATCGCC CTGCGGAGGT CCATGGACCA GGGCAGCACA
TGGTCTCCTA CAGCGTTCAT TGTCAATGAT GGGGATGTCC CCGATGGGCT GAACCTTGGG
GCAGTAGTGA GCGATGTTGA GACAGGAGTA GTATTTCTTT TCTACTCCCT TTGTGCTCAC
AAGGCCGGCT GCCAGGTGGC CTCTACCATG TTGGTATGGA GCAAGGATGA TGGTGTTTCC
TGGAGCACAC CCCGGAATCT CTCCCTGGAT ATTGGCACTG AAGTGTTTGC CCCTGGACCG
GGCTCTGGTA TTCAGAAACA GCGGGAGCCA CGGAAGGGCC GCCTCATCGT GTGTGGCCAT
GGGACGCTGG AGCGGGACGG AGTCTTCTGT CTCCTCAGCG ATGATCATGG TGCCTCCTGG
CGCTACGGAA GTGGGGTCAG CGGCATCCCC TACGGTCAGC CCAAGCAGGA AAATGATTTC
AATCCTGATG AATGCCAGCC CTATGAGCTC CCAGATGGCT CAGTCGTCAT CAATGCCCGA
AACCAGAACA ACTACCACTG CCACTGCCGA ATTGTCCTCC GCAGCTATGA TGCCTGTGAT
ACACTAAGGC CCCGTGATGT GACCTTCGAC CCTGAGCTCG TGGACCCTGT GGTAGCTGCA
GGAGCTGTAG TCACCAGCTC CGGCATTGTC TTCTTCTCCA ACCCAGCACA TCCAGAGTTC
CGAGTGAACC TGACCCTGCG ATGGAGCTTC AGCAATGGTA CCTCATGGCG GAAAGAGACA
GTCCAGCTAT GGCCAGGCCC CAGTGGCTAT TCATCCCTGG CAACCCTGGA GGGCAGCATG
GATGGAGAGG AGCAGGCCCC CCAGCTCTAC GTCCTGTATG AGAAAGGCCG GAACCACTAC
ACAGAGAGCA TCTCCGTGGC CAAAATCAGT GTCTATGGGA CACTCTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OHu26827 Clone ID Related Accession (Same CDS sequence) NM_000434.3 , NM_000434.4 Accession Version NM_000434.4 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 1248bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1577808000000 Organism Homo sapiens(human) Product sialidase-1 precursor Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC000722.2, CA428930.1 and AL671762.10. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_000434.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.50482.1, SRR1803611.166177.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000375631.5/ ENSP00000364782.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201ATGACTGGGG AGCGACCCAG CACGGCGCTC CCGGACAGAC GCTGGGGGCC GCGGATTCTG
GGCTTCTGGG GAGGCTGTAG GGTTTGGGTG TTTGCCGCGA TCTTCCTGCT GCTGTCTCTG
GCAGCCTCCT GGTCCAAGGC TGAGAACGAC TTCGGTCTGG TGCAGCCGCT GGTGACCATG
GAGCAACTGC TGTGGGTGAG CGGGAGACAG ATCGGCTCAG TGGACACCTT CCGCATCCCG
CTCATCACAG CCACTCCGCG GGGCACTCTT CTCGCCTTTG CTGAGGCGAG GAAAATGTCC
TCATCCGATG AGGGGGCCAA GTTCATCGCC CTGCGGAGGT CCATGGACCA GGGCAGCACA
TGGTCTCCTA CAGCGTTCAT TGTCAATGAT GGGGATGTCC CCGATGGGCT GAACCTTGGG
GCAGTAGTGA GCGATGTTGA GACAGGAGTA GTATTTCTTT TCTACTCCCT TTGTGCTCAC
AAGGCCGGCT GCCAGGTGGC CTCTACCATG TTGGTATGGA GCAAGGATGA TGGTGTTTCC
TGGAGCACAC CCCGGAATCT CTCCCTGGAT ATTGGCACTG AAGTGTTTGC CCCTGGACCG
GGCTCTGGTA TTCAGAAACA GCGGGAGCCA CGGAAGGGCC GCCTCATCGT GTGTGGCCAT
GGGACGCTGG AGCGGGACGG AGTCTTCTGT CTCCTCAGCG ATGATCATGG TGCCTCCTGG
CGCTACGGAA GTGGGGTCAG CGGCATCCCC TACGGTCAGC CCAAGCAGGA AAATGATTTC
AATCCTGATG AATGCCAGCC CTATGAGCTC CCAGATGGCT CAGTCGTCAT CAATGCCCGA
AACCAGAACA ACTACCACTG CCACTGCCGA ATTGTCCTCC GCAGCTATGA TGCCTGTGAT
ACACTAAGGC CCCGTGATGT GACCTTCGAC CCTGAGCTCG TGGACCCTGT GGTAGCTGCA
GGAGCTGTAG TCACCAGCTC CGGCATTGTC TTCTTCTCCA ACCCAGCACA TCCAGAGTTC
CGAGTGAACC TGACCCTGCG ATGGAGCTTC AGCAATGGTA CCTCATGGCG GAAAGAGACA
GTCCAGCTAT GGCCAGGCCC CAGTGGCTAT TCATCCCTGG CAACCCTGGA GGGCAGCATG
GATGGAGAGG AGCAGGCCCC CCAGCTCTAC GTCCTGTATG AGAAAGGCCG GAACCACTAC
ACAGAGAGCA TCTCCGTGGC CAAAATCAGT GTCTATGGGA CACTCTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_000425.1 CDS 46..1293 Translation
Target ORF information:
RefSeq Version NM_000434.4 Organism Homo sapiens(human) Definition Homo sapiens neuraminidase 1 (NEU1), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK NM_000434.4
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201ATGACTGGGG AGCGACCCAG CACGGCGCTC CCGGACAGAC GCTGGGGGCC GCGGATTCTG
GGCTTCTGGG GAGGCTGTAG GGTTTGGGTG TTTGCCGCGA TCTTCCTGCT GCTGTCTCTG
GCAGCCTCCT GGTCCAAGGC TGAGAACGAC TTCGGTCTGG TGCAGCCGCT GGTGACCATG
GAGCAACTGC TGTGGGTGAG CGGGAGACAG ATCGGCTCAG TGGACACCTT CCGCATCCCG
CTCATCACAG CCACTCCGCG GGGCACTCTT CTCGCCTTTG CTGAGGCGAG GAAAATGTCC
TCATCCGATG AGGGGGCCAA GTTCATCGCC CTGCGGAGGT CCATGGACCA GGGCAGCACA
TGGTCTCCTA CAGCGTTCAT TGTCAATGAT GGGGATGTCC CCGATGGGCT GAACCTTGGG
GCAGTAGTGA GCGATGTTGA GACAGGAGTA GTATTTCTTT TCTACTCCCT TTGTGCTCAC
AAGGCCGGCT GCCAGGTGGC CTCTACCATG TTGGTATGGA GCAAGGATGA TGGTGTTTCC
TGGAGCACAC CCCGGAATCT CTCCCTGGAT ATTGGCACTG AAGTGTTTGC CCCTGGACCG
GGCTCTGGTA TTCAGAAACA GCGGGAGCCA CGGAAGGGCC GCCTCATCGT GTGTGGCCAT
GGGACGCTGG AGCGGGACGG AGTCTTCTGT CTCCTCAGCG ATGATCATGG TGCCTCCTGG
CGCTACGGAA GTGGGGTCAG CGGCATCCCC TACGGTCAGC CCAAGCAGGA AAATGATTTC
AATCCTGATG AATGCCAGCC CTATGAGCTC CCAGATGGCT CAGTCGTCAT CAATGCCCGA
AACCAGAACA ACTACCACTG CCACTGCCGA ATTGTCCTCC GCAGCTATGA TGCCTGTGAT
ACACTAAGGC CCCGTGATGT GACCTTCGAC CCTGAGCTCG TGGACCCTGT GGTAGCTGCA
GGAGCTGTAG TCACCAGCTC CGGCATTGTC TTCTTCTCCA ACCCAGCACA TCCAGAGTTC
CGAGTGAACC TGACCCTGCG ATGGAGCTTC AGCAATGGTA CCTCATGGCG GAAAGAGACA
GTCCAGCTAT GGCCAGGCCC CAGTGGCTAT TCATCCCTGG CAACCCTGGA GGGCAGCATG
GATGGAGAGG AGCAGGCCCC CCAGCTCTAC GTCCTGTATG AGAAAGGCCG GAACCACTAC
ACAGAGAGCA TCTCCGTGGC CAAAATCAGT GTCTATGGGA CACTCTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
Histamine-mediated potentiation of transient receptor potential (TRP) ankyrin 1 and TRP vanilloid 4 signaling in submucosal neurons in patients with irritable bowel syndrome.
American journal of physiology. Gastrointestinal and liver physiology316(3)G338-G349(2019 03)
Balemans D,Aguilera-Lizarraga J,Florens MV,Jain P,Denadai-Souza A,Viola MF,Alpizar YA,Van Der Merwe S,Vanden Berghe P,Talavera K,Vanner S,Wouters MM,Boeckxstaens GE
Identification of CD36 as a new interaction partner of membrane NEU1: potential implication in the pro-atherogenic effects of the elastin receptor complex.
Cellular and molecular life sciences : CMLS76(4)791-807(2019 Feb)
Kawecki C,Bocquet O,Schmelzer CEH,Heinz A,Ihling C,Wahart A,Romier B,Bennasroune A,Blaise S,Terryn C,Linton KJ,Martiny L,Duca L,Maurice P
Molecular characterization of Portuguese patients with dilated cardiomyopathy.
Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology38(2)129-139(2019 02)
Sousa A,Canedo P,Azevedo O,Lopes L,Pinho T,Baixia M,Rocha-Gonçalves F,Gonçalves L,Cardoso JS,Machado JC,Martins E,
Quantitation of all Four Gardnerella vaginalis Clades Detects Abnormal Vaginal Microbiota Characteristic of Bacterial Vaginosis More Accurately than Putative G. vaginalis Sialidase A Gene Count.
Molecular diagnosis & therapy23(1)139-147(2019 02)
Shipitsyna E,Krysanova A,Khayrullina G,Shalepo K,Savicheva A,Guschin A,Unemo M
Association of TRPV1 and TLR4 through the TIR domain potentiates TRPV1 activity by blocking activation-induced desensitization.
Molecular pain141744806918812636(2018 Jan-Dec)
Min H,Cho WH,Lee H,Choi B,Kim YJ,Lee HK,Joo Y,Jung SJ,Choi SY,Lee S,Lee SJ
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