| Gene Symbol | GFRAL |
| Entrez Gene ID | 389400 |
| Full Name | GDNF family receptor alpha like |
| Synonyms | C6orf144,GRAL,UNQ9356,bA360D14.1 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Disorder MIM: |
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GFRAL cDNA ORF clone, Homo sapiens(human)
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Gene
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Clones
gRNAs
The following GFRAL gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GFRAL cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OHu31183 
Clone ID Related Accession (Same CDS sequence) NM_207410.2 Accession Version NM_207410.2 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 1185bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1561737600000 Organism Homo sapiens(human) Product GDNF family receptor alpha-like precursor Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AY358198.1 and AL592426.9. On May 23, 2007 this sequence version replaced NM_207410.1. ##Evidence-Data-START## Transcript exon combination :: AY358198.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968968, SAMEA2142680 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000340465.2/ ENSP00000343636.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141ATGATAGTGT TTATTTTCTT GGCTATGGGG TTAAGCTTGG AAAATGAATA CACTTCCCAA
ACCAATAATT GCACATATTT AAGAGAGCAA TGCTTACGTG ATGCAAATGG ATGTAAACAT
GCTTGGAGAG TAATGGAAGA TGCCTGCAAT GATTCAGATC CAGGTGACCC CTGCAAGATG
AGGAATTCAT CATACTGTAA CCTGAGTATC CAGTACTTAG TGGAAAGCAA TTTCCAATTT
AAAGAGTGTC TTTGCACTGA TGACTTCTAT TGTACTGTGA ACAAACTGCT TGGAAAAAAA
TGTATCAATA AATCAGATAA CGTGAAAGAG GATAAATTCA AATGGAATCT AACTACACGT
TCCCATCATG GATTCAAAGG GATGTGGTCC TGTTTGGAAG TGGCAGAGGC ATGTGTAGGG
GATGTGGTCT GTAATGCACA GTTGGCCTCT TACCTTAAAG CTTGCTCAGC AAATGGAAAT
CCGTGTGATC TGAAACAGTG CCAAGCAGCC ATACGGTTCT TCTATCAAAA TATACCTTTT
AACATTGCCC AGATGTTGGC TTTTTGTGAC TGTGCTCAAT CTGATATACC TTGTCAGCAG
TCCAAAGAAG CTCTTCACAG CAAGACATGT GCAGTGAACA TGGTTCCACC CCCTACTTGC
CTCAGTGTAA TTCGCAGCTG CCAAAATGAT GAATTATGCA GGAGGCACTA TAGAACATTT
CAGTCAAAAT GCTGGCAGCG TGTGACTAGA AAGTGCCATG AAGATGAGAA TTGCATTAGC
ACCTTAAGCA AACAGGACCT CACTTGTTCA GGAAGTGATG ACTGCAAAGC TGCTTACATA
GATATCCTTG GGACGGTCCT TCAAGTGCAA TGTACCTGTA GGACCATTAC ACAAAGTGAG
GAATCTTTGT GTAAGATTTT CCAGCACATG CTTCATAGAA AATCATGTTT CAATTATCCA
ACCCTGTCTA ATGTCAAAGG CATGGCATTG TATACAAGAA AACATGCAAA CAAAATCACT
TTAACTGGAT TTCATTCCCC CTTCAATGGA GAAGTAATCT ATGCTGCCAT GTGCATGACA
GTCACCTGTG GAATCCTTCT GTTGGTTATG GTCAAGCTTA GAACTTCCAG AATATCAAGT
AAAGCAAGAG ATCCTTCATC GATCCAAATA CCTGGAGAAC TCTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_997293.2 CDS 87..1271 Translation 
Target ORF information:
RefSeq Version NM_207410.2 Organism Homo sapiens(human) Definition Homo sapiens GDNF family receptor alpha like (GFRAL), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_207410.2
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141ATGATAGTGT TTATTTTCTT GGCTATGGGG TTAAGCTTGG AAAATGAATA CACTTCCCAA
ACCAATAATT GCACATATTT AAGAGAGCAA TGCTTACGTG ATGCAAATGG ATGTAAACAT
GCTTGGAGAG TAATGGAAGA TGCCTGCAAT GATTCAGATC CAGGTGACCC CTGCAAGATG
AGGAATTCAT CATACTGTAA CCTGAGTATC CAGTACTTAG TGGAAAGCAA TTTCCAATTT
AAAGAGTGTC TTTGCACTGA TGACTTCTAT TGTACTGTGA ACAAACTGCT TGGAAAAAAA
TGTATCAATA AATCAGATAA CGTGAAAGAG GATAAATTCA AATGGAATCT AACTACACGT
TCCCATCATG GATTCAAAGG GATGTGGTCC TGTTTGGAAG TGGCAGAGGC ATGTGTAGGG
GATGTGGTCT GTAATGCACA GTTGGCCTCT TACCTTAAAG CTTGCTCAGC AAATGGAAAT
CCGTGTGATC TGAAACAGTG CCAAGCAGCC ATACGGTTCT TCTATCAAAA TATACCTTTT
AACATTGCCC AGATGTTGGC TTTTTGTGAC TGTGCTCAAT CTGATATACC TTGTCAGCAG
TCCAAAGAAG CTCTTCACAG CAAGACATGT GCAGTGAACA TGGTTCCACC CCCTACTTGC
CTCAGTGTAA TTCGCAGCTG CCAAAATGAT GAATTATGCA GGAGGCACTA TAGAACATTT
CAGTCAAAAT GCTGGCAGCG TGTGACTAGA AAGTGCCATG AAGATGAGAA TTGCATTAGC
ACCTTAAGCA AACAGGACCT CACTTGTTCA GGAAGTGATG ACTGCAAAGC TGCTTACATA
GATATCCTTG GGACGGTCCT TCAAGTGCAA TGTACCTGTA GGACCATTAC ACAAAGTGAG
GAATCTTTGT GTAAGATTTT CCAGCACATG CTTCATAGAA AATCATGTTT CAATTATCCA
ACCCTGTCTA ATGTCAAAGG CATGGCATTG TATACAAGAA AACATGCAAA CAAAATCACT
TTAACTGGAT TTCATTCCCC CTTCAATGGA GAAGTAATCT ATGCTGCCAT GTGCATGACA
GTCACCTGTG GAATCCTTCT GTTGGTTATG GTCAAGCTTA GAACTTCCAG AATATCAAGT
AAAGCAAGAG ATCCTTCATC GATCCAAATA CCTGGAGAAC TCTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand.
Nature medicine23(10)1158-1166(2017 Oct)
Yang L,Chang CC,Sun Z,Madsen D,Zhu H,Padkjær SB,Wu X,Huang T,Hultman K,Paulsen SJ,Wang J,Bugge A,Frantzen JB,Nørgaard P,Jeppesen JF,Yang Z,Secher A,Chen H,Li X,John LM,Shan B,He Z,Gao X,Su J,Hansen KT,Yang W,Jørgensen SB
The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL.
Nature medicine23(10)1215-1219(2017 Oct)
Emmerson PJ,Wang F,Du Y,Liu Q,Pickard RT,Gonciarz MD,Coskun T,Hamang MJ,Sindelar DK,Ballman KK,Foltz LA,Muppidi A,Alsina-Fernandez J,Barnard GC,Tang JX,Liu X,Mao X,Siegel R,Sloan JH,Mitchell PJ,Zhang BB,Gimeno RE,Shan B,Wu X
GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates.
Nature medicine23(10)1150-1157(2017 Oct)
Mullican SE,Lin-Schmidt X,Chin CN,Chavez JA,Furman JL,Armstrong AA,Beck SC,South VJ,Dinh TQ,Cash-Mason TD,Cavanaugh CR,Nelson S,Huang C,Hunter MJ,Rangwala SM
Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15.
Nature550(7675)255-259(2017 10)
Hsu JY,Crawley S,Chen M,Ayupova DA,Lindhout DA,Higbee J,Kutach A,Joo W,Gao Z,Fu D,To C,Mondal K,Li B,Kekatpure A,Wang M,Laird T,Horner G,Chan J,McEntee M,Lopez M,Lakshminarasimhan D,White A,Wang SP,Yao J,Yie J,Matern H,Solloway M,Haldankar R,Parsons T,Tang J,Shen WD,Alice Chen Y,Tian H,Allan BB
Identification, expression and functional characterization of the GRAL gene.
Journal of neurochemistry95(2)361-76(2005 Oct)
Li Z,Wang B,Wu X,Cheng SY,Paraoan L,Zhou J
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